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1

Morão, B., J. Revés, C. Nascimento, et al. "DOP15 Intestinal ultrasound correlates with colonoscopy and biomarkers, and can be used in a tight monitoring approach to assess response to therapy in Crohn's disease: a multicentre prospective study." Journal of Crohn's and Colitis 17, Supplement_1 (2023): i77—i79. http://dx.doi.org/10.1093/ecco-jcc/jjac190.0055.

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Abstract Background Intestinal ultrasound (IUS) is a non-invasive monitoring tool increasingly being used to assess response to therapy in Crohn’s disease (CD). Herein we describe the longitudinal evolution of IUS parameters, and its correlation with clinical, laboratorial and endoscopic parameters during the first year of infliximab (IFX) therapy. Methods Prospective multicentre cohort study of patients with active CD starting IFX. Harvey-Bradshaw index (HBI), C-reactive protein (CRP), fecal calprotectin (FC) and IUS were performed at week (W) 0, 14, 30 and 54. Ileocolonoscopy was performed a
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2

Kim, Mi Kyoung, Seok Ju Seong, Jae-Weon Kim, et al. "Management of Endometrial Hyperplasia With a Levonorgestrel-Releasing Intrauterine System: A Korean Gynecologic-Oncology Group Study." International Journal of Gynecologic Cancer 26, no. 4 (2016): 711–15. http://dx.doi.org/10.1097/igc.0000000000000669.

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ObjectiveThe aim of the study was to evaluate the efficacy of the levonorgestrel intrauterine system (LNG-IUS) for treatment of endometrial hyperplasia (EH).MethodsA prospective multicenter study was conducted from November 2010 to March 2014. Patients with histologically confirmed EH were treated with LNG-IUS. At 3, 6, and 9 months after LNG-IUS insertion, follow-up endometrial aspiration biopsies with the LNG-IUS in the uterus were undertaken. At the 12th month of follow-up, endometrial tissues were obtained via 2 methods: endometrial aspiration biopsy with the LNG-IUS in the uterus, followe
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3

Haley, Kathleen J., Jessica Lasky-Su, Sara E. Manoli, et al. "RUNX transcription factors: association with pediatric asthma and modulated by maternal smoking." American Journal of Physiology-Lung Cellular and Molecular Physiology 301, no. 5 (2011): L693—L701. http://dx.doi.org/10.1152/ajplung.00348.2010.

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Intrauterine smoke exposure (IUS) is a strong risk factor for development of airways responsiveness and asthma in childhood. Runt-related transcription factors (RUNX1–3) have critical roles in immune system development and function. We hypothesized that genetic variations in RUNX1 would be associated with airway responsiveness in asthmatic children and that this association would be modified by IUS. Family-based association testing analysis in the Childhood Asthma Management Program genome-wide genotype data showed that 17 of 100 RUNX1 single-nucleotide polymorphisms (SNPs) were significantly
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4

MACCARI, Aurora. "Habebat ius proferendi pomerii (Gell., Noctes Atticae, XIII, 14). L’evoluzione dello ius prolationis dalle origini a silla." Studi Classici e Orientali, no. 62 (2016): 161–84. http://dx.doi.org/10.12871/97888674165478.

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Elli, Luca, Erica Centorrino, Andrea Costantino, Maurizio Vecchi, Stefania Orlando, and Mirella Fraquelli. "Capsule enteroscopy versus small-bowel ultrasonography for the detection and differential diagnosis of intestinal diseases." Clinical Endoscopy 55, no. 4 (2022): 532–39. http://dx.doi.org/10.5946/ce.2021.224.

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Background/Aims: Capsule enteroscopy (CE) and intestinal ultrasonography (IUS) are techniques that are currently used for investigating small-bowel (SB) diseases. The aim of this study was to compare the main imaging findings and the lesion detection rate (LDR) of CE and IUS in different clinical scenarios involving the SB.Methods: We retrospectively enrolled patients who underwent CE and IUS for obscure gastrointestinal bleeding (OGIB), complicated celiac disease (CeD), and suspected or known inflammatory bowel disease (IBD). We evaluated the LDR of both techniques. The accuracy of IUS was de
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6

Sharma, Sunita, Alvin T. Kho, Divya Chhabra, et al. "Effect of Intrauterine Smoke Exposure on microRNA-15a Expression in Human Lung Development and Subsequent Asthma Risk." Healthcare 8, no. 4 (2020): 536. http://dx.doi.org/10.3390/healthcare8040536.

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Background: In utero smoke (IUS) exposure is associated with asthma susceptibility. Objective: We sought to test the hypothesis that changes in miRNA expression by IUS exposure during human lung development is associated with asthma susceptibility. Methods: Gene expression was profiled from 53 IUS unexposed and 51 IUS exposed human fetal lung tissues. We tested for the differential expression of miRNAs across post-conception age and by IUS using linear models with covariate adjustment. We tested the IUS-associated miRNAs for association with their gene expression targets using pair-wise invers
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7

Steinway, Caren, J. Felipe Garcia-Espana, Jennifer Harding, and Aletha Akers. "Satisfaction With IUS Insertion in Adolescents 14-22 Years Old." Journal of Pediatric and Adolescent Gynecology 30, no. 2 (2017): 322–23. http://dx.doi.org/10.1016/j.jpag.2017.03.118.

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8

Morão, B., C. Nascimento, C. Frias Gomes, et al. "P152 Bowel ultrasound as an early monitoring tool to assess disease activity in Crohn’s disease patients after induction therapy with infliximab." Journal of Crohn's and Colitis 15, Supplement_1 (2021): S232. http://dx.doi.org/10.1093/ecco-jcc/jjab076.279.

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Abstract Background Bowel wall thickness (BWT) is an accurate sonographic parameter to assess disease activity in Crohn’s disease (CD). International Bowel Ultrasound Segmental Activity Score (IBUS-SAS) was developed to allow a reproducible assessment of intestinal inflammation in CD using bowel ultrasound (IUS). Aim to assess BWT and IBUS-SAS variation after induction therapy with infliximab (IFX) and their correlation with clinical and laboratory parameters. Methods Prospective multicentre study including patients with active CD starting IFX. Harvey-Bradshaw index (HBI), C-reactive protein (
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9

Perin, Alessandro, Francesco Ugo Prada, Michela Moraldo, et al. "USim: A New Device and App for Case-Specific, Intraoperative Ultrasound Simulation and Rehearsal in Neurosurgery. A Preliminary Study." Operative Neurosurgery 14, no. 5 (2017): 572–78. http://dx.doi.org/10.1093/ons/opx144.

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Abstract BACKGROUND Intraoperative ultrasound (iUS) is an excellent aid for neurosurgeons to perform better and safer operations thanks to real time, continuous, and high-quality intraoperative visualization. OBJECTIVE To develop an innovative training method to teach how to perform iUS in neurosurgery. METHODS Patients undergoing surgery for different brain or spine lesions were iUS scanned (before opening the dura) in order to arrange a collection of 3-dimensional, US images; this set of data was matched and paired to preoperatively acquired magnetic resonance images in order to create a lib
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10

Chu, M., A. Day, R. Mathias, et al. "P499 Exclusive enteral nutrition induces transmural healing in adults with active Crohn’s disease." Journal of Crohn's and Colitis 17, Supplement_1 (2023): i628—i629. http://dx.doi.org/10.1093/ecco-jcc/jjac190.0629.

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Abstract Background Exclusive enteral nutrition (EEN) is a nutrition-based therapy for active Crohn’s Disease (CD). Transmural healing is a novel therapeutic paradigm in CD, holding benefit beyond endoscopic mucosal healing. There are limited data exploring EEN and transmural healing in CD. We aimed to examine the effect of EEN on inducing transmural response and healing as assessed by intestinal ultrasonography (IUS). Methods This was a prospective, multi-centre, open-label cohort study. Adults ≥18 years with active CD were enrolled between March to September 2022. Eligible, consenting partic
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11

Bergeron, Catherine, Philippe Y. Laberge, Amélie Boutin, et al. "Endometrial ablation or resection versus levonorgestrel intra-uterine system for the treatment of women with heavy menstrual bleeding and a normal uterine cavity: a systematic review with meta-analysis." Human Reproduction Update 26, no. 2 (2020): 302–11. http://dx.doi.org/10.1093/humupd/dmz051.

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Abstract BACKGROUND Endometrial ablation/resection and the levonorgestrel intra-uterine system (LNG-IUS) are well-established treatment options for heavy menstrual bleeding to avoid more invasive alternatives, such as hysterectomy. OBJECTIVE The aim was to compare the efficacy and safety of endometrial ablation or resection with the LNG-IUS in the treatment of premenopausal women with heavy menstrual bleeding and to investigate sources of heterogeneity between studies. SEARCH METHODS We searched the databases MEDLINE, EMBASE, CENTRAL, Web of Science, Biosis and Google Scholar as well as citati
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12

Morão, B., C. Frias Gomes, J. Revés, et al. "P499 Accessing ultrasonographic transmural healing in patients with Crohn’s disease after induction therapy with infliximab: should we aim for higher infliximab trough levels?" Journal of Crohn's and Colitis 16, Supplement_1 (2022): i462. http://dx.doi.org/10.1093/ecco-jcc/jjab232.626.

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Abstract Background Higher infliximab trough levels (ITL) have been shown to be associated with better rates of clinical remission and mucosal healing. Transmural healing (TMH) assessed by cross-sectional imaging [such as intestinal ultrasound (IUS)] is emerging as a potential target in Crohn′s disease (CD) treatment, but whether there is any relation with ITL remains unclear. Our goal was to investigate the association between ITL and bowel wall thickness (BWT) in patients with CD after induction therapy with IFX. Methods Prospective multicentric cohort study of CD patients who started IFX in
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13

Petit, Carlos. "Petit Calvo, Carlos, Handelsrecht und Rechtsgeschichte. Mit einem Vorwort von Joachim Rückert." Zeitschrift der Savigny-Stiftung für Rechtsgeschichte: Germanistische Abteilung 136, no. 1 (2019): 306–37. http://dx.doi.org/10.1515/zrgg-2019-0011.

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Abstract Commercial Law and Legal History This invited article summarizes the main points of my recent book 'Historia del Derecho Mercantil' from the commercial culture of the Ancien Régime to the legal culture of the legislative State (2016), adding one additional finding by Paolo Prodi. Inhalt: Präsentation. (1) ius mercatorum als Handelskultur. (2) Recht und Kultur. (3) Verdächtige, aber notwendige und legitime Aktivitäten. (4) Strukturen des ius mercatorum (5) Handelsregeln und ökonomische Macht der Monarchie. (6) „Non rubare" ein bedauerliches Versäumnis. (7) Beschreibung des Handelsrecht
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14

Lovett, G., J. D. Schulberg, A. L. Hamilton, E. K. Wright, T. R. Sutherland, and M. A. Kamm. "P749 Crohn’s disease stricture response and resolution with adalimumab therapy demonstrated with intestinal ultrasound. The STRIDENT randomised trial." Journal of Crohn's and Colitis 17, Supplement_1 (2023): i879—i880. http://dx.doi.org/10.1093/ecco-jcc/jjac190.0879.

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Abstract Background Transmural healing is a treatment goal in the management of Crohn’s disease, and intestinal ultrasound (IUS) is potentially a sensitive, non-invasive and reproducible means to assess the response to treatment. Methods The STRIDENT (Stricture Definition and Treatment) study was a randomised controlled trial of standard dose monotherapy adalimumab versus intensive high-dose adalimumab combined with a thiopurine. Crohn’s disease patients with symptomatic intestinal strictures were randomised 2:1 to high dose adalimumab induction (160mg weekly for 4 weeks) with 40mg fortnightly
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15

Repgen, Tilman. "Maximiliane Kriechbaum, Actio, ius und dominium in den Rechtslehren des 13. und 14. Jahrhunderts." Zeitschrift der Savigny-Stiftung für Rechtsgeschichte. Romanistische Abteilung 116, no. 1 (1999): 424–28. http://dx.doi.org/10.7767/zrgra.1999.116.1.424.

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Ferreira, Jessica M., Ilza Monteiro, Arlete Fernandes, Maria V. Bahamondes, Ana Pitoli, and Luis Bahamondes. "Estimated disability-adjusted life years averted by free-of-charge provision of the levonorgestrel-releasing intrauterine system over a 9-year period in Brazil." Journal of Family Planning and Reproductive Health Care 43, no. 3 (2017): 181–85. http://dx.doi.org/10.1136/jfprhc-2016-101569.

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BackgroundThe objective was to analyse the contribution of the provision at no cost to users of the 20 µg/day levonorgestrel-releasing intrauterine system (LNG-IUS) towards disability-adjusted life years (DALY) averted over a 9-year period.MethodsWe analysed data from 15 030 new users of the LNG-IUS who had the device inserted at 26 Brazilian teaching hospitals between January 2007 and December 2015. The devices came from the International Contraceptive Access Foundation (ICA), a not-for-profit foundation that donates the devices to developing countries for use by low-income women who desire l
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17

Hwang, Ji Young, Da Hee Kim, Hyo Sook Bae, et al. "Combined Oral Medroxyprogesterone/Levonorgestrel-Intrauterine System Treatment for Women With Grade 2 Stage IA Endometrial Cancer." International Journal of Gynecologic Cancer 27, no. 4 (2017): 738–42. http://dx.doi.org/10.1097/igc.0000000000000927.

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ObjectiveThe aim of this study was to evaluate the oncologic and pregnancy outcomes of combined oral medroxyprogesterone acetate (MPA)/levonorgestrel-intrauterine system (LNG-IUS) treatment in young women with grade 2–differentiated stage IA endometrial adenocarcinoma who wish to preserve fertility.MethodsWe retrospectively reviewed the medical records of patients with grade 2 stage IA endometrial adenocarcinoma who had received fertility-sparing treatment at CHA Gangnam Medical Center between 2011 and 2015. All of the patients were treated with combined oral MPA (500 mg/d)/LNG-IUS, and follow
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18

Lovett, G., J. D. Schulberg, A. L. Hamilton, H. E. Wilding, M. A. Kamm, and E. K. Wright. "P587 Intestinal ultrasound (IUS) and magnetic resonance imaging (MRI) for monitoring of response to therapy in luminal Crohn’s disease – a systematic review." Journal of Crohn's and Colitis 17, Supplement_1 (2023): i715—i716. http://dx.doi.org/10.1093/ecco-jcc/jjac190.0717.

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Abstract Background Mucosal and transmural healing are associated with better outcomes in Crohn’s disease. Magnetic resonance imaging (MRI) and intestinal ultrasound (IUS) provide non-invasive cross-sectional assessment of disease activity and transmural healing. This systematic review addresses the utility of MRI and IUS in the assessment of disease activity and transmural healing in response to drug therapy when compared to endoscopy in patients with luminal Crohn’s disease. Methods Database searches were undertaken (Medline, Embase, Emcare, APA PsycInfo, CINAHL, Cochrane Library) following
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19

Sobański, Remigiusz. "Niezmienność i historyczność prawa w Kościele : prawo Boże i prawo ludzkie." Prawo Kanoniczne 40, no. 1-2 (1997): 23–44. http://dx.doi.org/10.21697/pk.1997.40.1-2.01.

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Si présenta la versione polacca della relazione tenu ta il 14 novembre 1996 al Convegno internaziale di studi organizzato delle Università degli studi „La Sapienza” e „Tor Vergata” e dal Pontificio Ateneo della Santa Croce a Roma 13-16.11.1996 sul tema: La Scienza Canonistica nella seconda metj del 1900: Fondamenti, metodi, prospettive in D’Avack - Lombardia - Gismondi - Corecco. Il testo originale é pubblicato in „Ius Ecclesiae” 1997.
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20

Miyoshi, J., R. Ozaki, H. Yonezawa, et al. "DOP16 The ratio of submucosa thickness to the total bowel wall thickness can be a sonographic parameter to estimate endoscopic remission in Ulcerative Colitis." Journal of Crohn's and Colitis 15, Supplement_1 (2021): S054—S055. http://dx.doi.org/10.1093/ecco-jcc/jjab073.055.

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Abstract Background A less invasive examination that can estimate endoscopic remission is needed. Intestinal ultrasound (IUS) is a promising option. The bowel wall thickness (BWT) is a widely-accepted objective parameter in IUS to assess colonic inflammation, but BWT is influenced by intestinal peristalsis and the volume of luminal content. A feasible, objective index that is not affected by these factors could improve the diagnostic potential of IUS. The submucosa, which is observed as the third layer of the intestinal wall on IUS, becomes swollen and standing out in the active UC. Given BWT
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de Voogd, F., S. Bots, K. Gecse, O. H. Gilja, G. D’Haens, and K. Nylund. "P580 Early intestinal ultrasound assessment predicts endoscopic response and remission on anti-TNF treatment in Crohn’s Disease – a prospective longitudinal cohort study." Journal of Crohn's and Colitis 16, Supplement_1 (2022): i520—i521. http://dx.doi.org/10.1093/ecco-jcc/jjab232.706.

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Abstract Background In the assessment of treatment response in Crohn’s Disease (CD) objective measures are superior to clinical improvement. Intestinal ultrasound (IUS) is an emerging modality with high accuracy to detect CD disease activity. Less is known about early transmural changes at IUS in treatment follow-up. Therefore, we aimed to investigate conventional IUS and contrast-enhanced ultrasound (CEUS) parameters and how they are associated with endoscopic treatment response. Methods In this longitudinal prospective cohort study, consecutive patients with active CD according to the simpli
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Nascimento, C., C. Frias Gomes, B. Morão, et al. "P145 Ultrasonographic parameters associated with mucosal healing 1 year after infliximab therapy in Crohn’s Disease: a multicentric and prospective study." Journal of Crohn's and Colitis 16, Supplement_1 (2022): i225—i226. http://dx.doi.org/10.1093/ecco-jcc/jjab232.273.

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Abstract Background Bowel wall thickness (BWT) is an accurate ultrasonographic parameter to assess disease activity in Crohn’s disease (CD). The IBUS-SAS score includes BWT, doppler sign, loss of stratification and inflammatory fat (i-fat) and allows a reproducible assessment of inflammation in CD using intestinal ultrasound (IUS). Our aim: to assess clinical, laboratorial and ultrasonographic predictors of mucosal healing (MH) at 1 year of infliximab (IFX) therapy. Methods Prospective multicentric cohort study including patients with active CD starting IFX. Harvey-Bradshaw index, C-reactive p
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Pallares Bossa, Jorge. "PRESENTACIÓN." Revista Jurídica Mario Alario D´Filippo 7, no. 14 (2015): 7–8. http://dx.doi.org/10.32997/2256-2796-vol.7-num.14/2015/266.

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 La Facultad de Derecho y Ciencias Polí cas de la Universidad de Cartagena presenta a laacademia el número 14 de la Revista Jurídica Mario Alario D’ Filippo, el cual es resultadodel trabajo cien co de los ius inves gadores que conforman la presente edición.
 Las líneas de derecho cons tucional, penal y criminología y loso a del derecho fueron lasseleccionadas por los pares evaluadores, quienes privilegiaron con su rigor la escogenciade los ar culos publicados.
 
 
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Revés, J., B. Morão, C. Nascimento, et al. "P333 Early intestinal ultrasound remission is associated with endoscopic healing after one year of infliximab therapy in Crohn’s disease: a multicentre prospective study." Journal of Crohn's and Colitis 17, Supplement_1 (2023): i470—i471. http://dx.doi.org/10.1093/ecco-jcc/jjac190.0463.

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Abstract Background Endoscopic healing (EH) is currently the consensual long-term treatment target to achieve in Crohn’s disease (CD). However, optimization of therapy based on an endoscopic response implies a delay as endoscopy is an invasive procedure and cannot be used longitudinally, stressing the need for non-invasive predictors of EH. We aimed to assess the predictive role of biomarkers and intestinal ultrasound (IUS) parameters after induction therapy to predict EH one year after infliximab (IFX) therapy. Methods Prospective multicentre cohort study including patients with active CD sta
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Nascimento, C., B. Morão, C. Frias Gomes, et al. "P505 Early therapeutic drug monitoring after induction therapy with infliximab: correlation with intestinal ultrasound." Journal of Crohn's and Colitis 15, Supplement_1 (2021): S487. http://dx.doi.org/10.1093/ecco-jcc/jjab076.627.

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Abstract Background Therapeutic drug monitoring (TDM) in patients receiving infliximab (IFX) has a role in assessing treatment and managing outcomes. Infliximab trough levels (ITL) have been suggested as useful markers for treatment optimization in Crohn’s disease (CD).Our goals were: to assess the relationship between ITL and transmural inflammation as assessed by intestinal ultrasound(IUS), following induction therapy with IFX; to assess which clinical, laboratorial or IUS parameters better predicted adequate levels by the end of induction therapy. Methods Prospective multicentric cohort stu
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Hadley, Visser, and Vander Steen. "Antioxidant Effect on Urinary Excretion of Malondialdehyde in Non-Athletes During Aerobic Training." International Journal for Vitamin and Nutrition Research 79, no. 1 (2009): 5–13. http://dx.doi.org/10.1024/0300-9831.79.1.5.

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Conditions in the body during aerobic exercise increase the level of lipid peroxidation (LP). LP is associated with elevated concentration of modified low-density lipoproteins that are implicated in development of cardiovascular disease. Supplementation with antioxidant vitamin E to athletes at 267 mg (400 IUs) or greater has been reported to reduce levels of LP associated with exercise. Little is currently known about the effects of modest supplementation of vitamin E on previously sedentary adults who initiate an aerobic fitness program. In the present study, sedentary subjects (n = 14) kept
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Calvo Moya, M. I., I. Omella Usieto, Y. González Lama, et al. "P545 Deep remission assessed by endoscopy, magnetic resonance or intestinal ultrasound, in refractory Crohn’s disease patients in clinical remission with ustekinumab: a real-life single-centre experience." Journal of Crohn's and Colitis 14, Supplement_1 (2020): S464—S465. http://dx.doi.org/10.1093/ecco-jcc/jjz203.673.

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Abstract Background Current therapeutic goals in Crohn’s disease (CD) include not only the mere absence of symptoms but also the objective resolution of macroscopic lesions, so-called deep remission (DR), which has been related to better outcomes. DR is usually acknowledged by endoscopy, although magnetic resonance (MR) or intestinal ultrasound (IUS) are also reliable, provide extramucosal information and may be more appropriate in certain clinical scenarios. Data regarding the achievement of DR with ustekinumab in real-life clinical practice is still scarce. Methods Retrospective cohort study
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Zabłocka, Maria. "Ius trium liberorum w ustawodawstwie dynastii julijsko-klaudyjskiej." Prawo Kanoniczne 29, no. 1-2 (1986): 243–64. http://dx.doi.org/10.21697/10.21697/10.21697/pk.1986.29.1-2.08.

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En voulant encourager les Romains à posséder plusieurs descendants Auguste prevoya les nom breux privilèges pour ceux qui avaient des enfants; Les hommes possédant des descendants avaient une position privilégiée dans le droit public (Gell. 2.15.4—6; Tac. Ann.2 .51; D. 4.2.2);. les époux qui avaient au moins un enfant regagnaient la capacitas totale dans le droit des successions. Mais c’est seulement lorsqu’on avait trois enfants qu’on recevait des privilèges spéciaux dans le domaine du froit civil. Ius trium liberorum concernait aussi bien les femmes que les hommes (Ep. Ulp. 16.1 a). L’homme
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Poggio, T., Guillermo jica, Joaquin Prada, and Edmundo Larrieu. "The Use of Immunodiagnostic Techniques in Sheep for the Epidemiological Surveillance of Cystic Echinococcosis." International Journal of Echinococcoses 1, no. 3 (2022): 88. http://dx.doi.org/10.5455/ije.2022.08.08.

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Objective: Cystic echinococcosis (CE) is a parasitic zoonosis caused by Echinococcus granulosus sensu lato. Immunodiagnostic techniques such as Western blot (WB) or enzyme-linked immunosorbent assay (ELISA), with different antigens, can be applied to the diagnosis of sheep for epidemiological surveillance purposes in control programs. However, its use is limited by the existence of antigenic cross-reactivity between different species of taeniidae present in sheep. Therefore, the usefulness of establishing surveillance systems based on the identification of infection present in a livestock esta
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Zakhari, Andrew, Emily Delpero, Sandra McKeown, George Tomlinson, Olga Bougie, and Ally Murji. "Endometriosis recurrence following post-operative hormonal suppression: a systematic review and meta-analysis." Human Reproduction Update 27, no. 1 (2020): 96–107. http://dx.doi.org/10.1093/humupd/dmaa033.

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Abstract BACKGROUND Although surgery for endometriosis can improve pain and fertility, the risk of disease recurrence is high. There is little consensus regarding the benefit of medical therapy in preventing recurrence of endometriosis following surgery. OBJECTIVE AND RATIONALE We performed a review of prospective observational studies and randomised controlled trials (RCTs) to evaluate the risk of endometriosis recurrence in patients undergoing post-operative hormonal suppression, compared to placebo/expectant management. SEARCH METHODS The following databases were searched from inception to
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Hamdan, H., Alwi Jaya, and Elvi Susanti Syam. "Batasan Perlindungan Hukum Bagi Anak yang Dapat Dipertanggungjawabkan sebagai Pelaku Kejahatan." Al-Ishlah: Jurnal Ilmiah Hukum 24, no. 1 (2021): 53–67. http://dx.doi.org/10.56087/aijih.v24i1.62.

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Penelitian ini bertujuan untuk mengetahui dan memahami batasan perlindungan hukum bagi anak yang dapat dipertanggungjawabkan sebagai pelaku kejahatan dan mengetahui dan memahami faktor-faktor yang mempengaruhi pertimbangan perlindungan hukum bagi anak yang dapat dipertanggungjawabkan sebagai pelaku kejahatan. Penelitian ini menggunakan pendekatan yuridis normatif. Adapun metode analisis dilakukan dengan cara mengidentifikasi secara sistematis, dipolarisasi, dikategorisasi dan dikelompokkan sesuai dengan alur pembahasan dalam penelitian ini. Berdasarkan uraian hasil dan pembahasan, maka dapat d
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Ranieri, Filippo. "Frank Soetermeer, Utrumque ius in peciis. Die Produktion juristischer Bücher an italienischen und französischen Universitäten des 13. und 14. Jahrhunderts, aus dem Niederländischen übersetzt von Gisela Iiiner." Zeitschrift der Savigny-Stiftung für Rechtsgeschichte. Romanistische Abteilung 122, no. 1 (2005): 352–55. http://dx.doi.org/10.7767/zrgra.2005.122.1.352.

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Zhuo, Lijun, Qian Wu, Hong Le, et al. "COVID-19-Related Intolerance of Uncertainty and Mental Health among Back-To-School Students in Wuhan: The Moderation Effect of Social Support." International Journal of Environmental Research and Public Health 18, no. 3 (2021): 981. http://dx.doi.org/10.3390/ijerph18030981.

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The current wave and future trend of the novel coronavirus disease 2019 (COVID-19) has triggered public uncertainty, causing unbearable psychological pressure on people. A cross-sectional online questionnaire was conducted among back-to-school students in Wuhan from 31 August 2020, to 14 September 2020, by using convenience sampling. A total of 1017 participants voluntarily provided sociodemographic characteristics and accomplished the following scales: the Intolerance of Uncertainty Scale (IUS-12), the Social Support Scale (SSQ), the Generalized Anxiety Disorder Scale (GAD-7), the Patient Hea
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Tambir, I. Made. "Pendekatan Restorative Justice dalam Penyelesaian Tindak Pidana di Tingkat Penyidikan." Jurnal Magister Hukum Udayana (Udayana Master Law Journal) 8, no. 4 (2019): 549. http://dx.doi.org/10.24843/jmhu.2019.v08.i04.p09.

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As the gateway to the criminal justice system, law enforcement that carried out by polri always influenced by social change factors. In accordance with the development of law today, polri required to be able to resolve criminal acts by prioritizing restorative justice approach. However it hasn’t been regulated in statutory. The research purposes to describe and analyze the settlement of criminal acts with restorative justice approach in investigation level at the present and the future. The research used normative legal research, using a statute approach, historical approach and comparative ap
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Revés, J., B. Morão, C. F. Gomes, et al. "P375 Faecal calprotectin variation after induction therapy with infliximab to predict clinical, endoscopic and ultrasonographic remission in Crohn’s disease patients." Journal of Crohn's and Colitis 16, Supplement_1 (2022): i378. http://dx.doi.org/10.1093/ecco-jcc/jjab232.502.

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Abstract Background Faecal calprotectin (FCal) is considered an intermediate target for monitoring disease activity in IBD. However, it is unknown whether early FCal variations during induction therapy may be a significant predictor of treatment response. We aimed to investigate FCal variation after infliximab induction therapy and its association with clinical, endoscopic, and ultrasonographic remission by the end of one year of treatment. Methods Prospective multicentric cohort study including patients with active CD without previous intestinal surgeries, who were starting IFX therapy and we
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Martinowitz, Uriel, Aaron Lubetsky, Elena Santagostino, et al. "Efficacy, PK and Safety Results of a Phase I/II Clinical Trial of Recombinant Fusion Protein Linking Coagulation Factor IX with Albumin (rIX-FP) in Previously Treated Patients with Haemophilia B (PROLONG - 9FP)." Blood 120, no. 21 (2012): 1121. http://dx.doi.org/10.1182/blood.v120.21.1121.1121.

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Abstract Abstract 1121 Factor IX (FIX) replacement therapy is the standard of care for patients with haemophilia B. FIX products currently available have a relatively short half-life, requiring 2–3 times a week intravenous prophylactic treatment to achieve a significant bleeding reduction. A recombinant FIX albumin fusion protein (rIX-FP) was generated by genetic fusion of human recombinant albumin to rFIX to extend the half life of FIX. A Phase I/II open-label, multicenter, clinical study of rIX-FP has been completed in previously treated patients with severe hemophilia B (FIX ≤ 2%) as part o
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Correale, P., P. Tagliaferri, F. Montagnani, et al. "Autoimmunity predicts prolonged survival in colon cancer patients undergoing GOLFIG biochemotherapy." Journal of Clinical Oncology 25, no. 18_suppl (2007): 14542. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.14542.

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14542 Background: A multi-center phase II trial has been designed to evaluate toxicity, anti-tumour and immune-biological activity of the bio-chemotherapy GOLFIG regimen in advanced colorectal cancer (A-CRC). Methods: The trial involved 46 patients (34/46 2nd line or more). The biweekly GOLFIG regimen consisted of gemcitabine (1,000 mg/m2, day 1), oxaliplatin (85 mg/m2, day 2), levofolinic acid (100 mg /m2, day 1,2) and 5-FU (400 mg/m2 as a bolus, and 800 mg/m2 as 24 hour infusion, days 1,2) followed by sc GM-CSF (100 μg, days 3 to 8) and sc IL-2 (0.5 X 106 IUs twice a day, days 9 to 14). Resu
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Correale, P., C. Remondo, F. Montagnani, et al. "Chemo-immunotherapy regimen with gemcitabine + FOLFOX 4 (GOLF) followed by subcutaneous (sc) granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-2 (IL-2). Results from a multicenter phase II trial in colon carcinoma patients." Journal of Clinical Oncology 24, no. 18_suppl (2006): 3587. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.3587.

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3587 We have recently described a poly-chemotherapy (GOLF) regimen that: A) is active in colon carcinoma patients as second line of therapy; B) induces high levels of necrosis and apoptosis in colon cancer cells; C) up-regulates the expression and release of heat shock proteins (HSP)-70 and -90 and tumour-associated antigens (2,3); and D) down-regulates tumour cell resistance to the death signals of cytotoxic-T-lymphocytes.These effects represented the rationale for projecting GOLFIG regimen. Here we describe the results of a multi-center translational phase II trial designed to evaluate the t
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Schulberg, J. D., A. L. Hamilton, E. K. Wright, et al. "P669 Improving Crohn’s disease stricture dilation outcome: Effect of repeated dilation, needle knife stricturotomy, and ongoing active inflammation." Journal of Crohn's and Colitis 17, Supplement_1 (2023): i801. http://dx.doi.org/10.1093/ecco-jcc/jjac190.0799.

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Abstract Background Traditionally Crohn’s disease strictures have been treated by a single endoscopic balloon dilation (EBD), repeated only for obstructive symptom recurrence. We postulated that scheduled repeated EBD may result in greater dilation effect than a single EBD; and that needle-knife stricturotomy (NKSt) may be a valuable salvage intervention in patients with strictures. Methods In this prospective observational study, patients with endoscopically accessible and short (<5cm), symptomatic Crohn’s disease stricture were assessed clinically (using an Obstructive Symptom Score [
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Yoke, Leah H., Michael Boeckh, Himanshu Banda, et al. "924. Cytomegalovirus (CMV) Retinitis during Maintenance Chemotherapy for Acute Lymphoblastic Leukemia." Open Forum Infectious Diseases 8, Supplement_1 (2021): S553—S554. http://dx.doi.org/10.1093/ofid/ofab466.1119.

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Abstract Background Acute leukemia patients are at risk for cytomegalovirus (CMV) retinitis following hematopoietic stem cell transplantation, though the disease can also occur in non-transplant adult leukemia patients. Emerging data suggest a shift to pediatric-inspired chemotherapy regimens in adults with acute lymphoblastic leukemia (ALL) can lead to increasing cytopenias and impaired functional immunity, placing these patients at risk for this opportunistic infection. Here we describe a case of CMV retinitis in an ALL patient following a lower-intensity regimen during maintenance chemother
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Healey Bird, B. R., N. Grant, K. Dunleavy, et al. "Treatment and biology of lymphomatoid granulomatosis." Journal of Clinical Oncology 25, no. 18_suppl (2007): 8029. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.8029.

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8029 Background: LYG is a rare angiocentric-destructive process with EBV+ B-cells and reactive T-cells. LYG is graded with grades I-II showing rare-moderate large EBV+ B-cells (usually polyclonal or oligoclonal) and grade III showing numerous large EBV+ B-cells (usually monoclonal), likely reflecting progressive transformation. Historically, steroids and/or chemotherapy have a 14 mos median survival. Methods: We are investigating Interferon-a (I-a) for grade I/II and dose-adjusted EPOCH ±Rituximab (R) for grade III LYG. Results: Characteristics of 53 pts are: male sex 68%; median age (range) 4
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Van De Wouw, Hans. "Opmerkingen Over De Aandacht Voor Het Romeinse Recht in De Middeleeuwen." Tijdschrift voor Rechtsgeschiedenis / Revue d'Histoire du Droit / The Legal History Review 61, no. 3 (1993): 335–47. http://dx.doi.org/10.1163/157181993x00196.

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AbstractEs geht hier nicht um eine Bibliographie, sondern um eine grobe Angabe der Hauptgebiete der Forschung, mit einigen Anregungen für die Arbeit in der nächsten Zukunft. In Belgien hat man sich wesentlich weniger mit dem mittelalterlichen römischen Recht beschäftigt als in den Niederlanden: das ist zu erklären durch die Bedeutung von Meijers und Feenstra, durch die Bevorzugung des kanonischen Rechts in Belgien und durch den Umstand, daß die südlichen Niederlande im Mittelalter höher entwickelt waren als die nördlichen, weshalb das einheimische Recht in Belgien den Forschern verhältnismäßig
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Melina, Putu Jelsi, and I. Ketut Sudiarta. "IUS CONSTITUENDUM PENGATURAN ZONASI WILAYAH PESISIR DAN PULAU-PULAU KECIL DI PROVINSI BALI." Kertha Semaya : Journal Ilmu Hukum 10, no. 4 (2022): 794. http://dx.doi.org/10.24843/ks.2022.v10.i04.p07.

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Tujuan dari adanya penelitian ini yaitu : pertama untuk mengetahui ruang lingkup pengaturan Peraturan terkait dengan wilayah pesisir di Provinsi Bali. Kedua untuk mengetahui bagaimanakah pengaturan yang ideal dimasa yang akan datang terkait dengan Rencana Zonasi Wilayah Pesisir dan Pulau-Pulau Kecil di Provinsi Bali agar dapat menjamin suatu kepastian hukum bagi masyarakat. Metode yang digunakan adalah penelitian hukum yang bersifat yuridis normatif yaitu metode yang mengacu kepada peraturan perundang-undangan dengan studi kepustakaan yang mempergunakan data sekunder, berupa bahan hukum primer
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Averyanova, Ekaterina A. "The Komsomol of Mordovia held festivals of youth and students in the second half of the 1950s." Humanitarian: actual problems of the humanities and education 20, no. 2 (2020): 162–73. http://dx.doi.org/10.15507/2078-9823.050.020.202002.162-173.

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Introduction. Festival forms of socio-cultural behavior, as an algorithm for displaying agitation, educational, and entertainment functions during mass events, have recently become the object of study. The need for scientific generalization creates an environment of mutual understanding to strengthen intercultural dialogue, have highlighted the attention to historical experience of such cross-cultural events, for analysis of strategies and mechanisms of translation of information and forms of behavior to create understanding in society and among the participants, promoting a positive image of
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de Almeida Ferrari, Lucia, and Carolina Godoi de Faria Marques. "O LEX-BR-Ius: arquitetura e decisões na compilação de um corpus representativo das leis federais brasileiras." Antares: letras e humanidades 14, no. 34 (2022): 40–77. http://dx.doi.org/10.18226/198449921.v.14.n.34.02.

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Tuzzahroh, Fatimah, and Sugiyarti Fatma Laela. "Sharia Audit and Shariah Compliance of Islamic Financial Institutions: A Bibliometric Analysis." Jurnal Ekonomi Syariah Teori dan Terapan 9, no. 6 (2022): 815–33. http://dx.doi.org/10.20473/vol9iss20226pp815-833.

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ABSTRAK Penelitian ini bertujuan untuk memetakan penelitian-penelitian sebelumnya tentang audit syariah dan perannya dalam meningkatkan kepatuhan syariah di lembaga keuangan syariah (LKS). Penelitian ini juga menguraikan tantangan yang dihadapi oleh LKS dan solusi dalam mengimplementasikan audit syariah. Sebanyak 308 publikasi diperoleh dari database Google scholar, Emerald Insight, Research Gate, Crossref, Microsoft Academic and Pubmed yang diakses dengan perangkat lunak Publish or Perish (PoP) dalam kurun waktu 2008-2021. Studi ini menerapkan analisis bibliometrik menggunakan VOSviewer, yang
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Singh, Vinita, and Donald Harvey. "3447 Effects of intranasal ketamine on uncontrolled cancer related pain." Journal of Clinical and Translational Science 3, s1 (2019): 40–42. http://dx.doi.org/10.1017/cts.2019.99.

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OBJECTIVES/SPECIFIC AIMS: If intranasal ketamine can be utilized for pain control in cancer patients, this could provide them with superior analgesia and better quality of life, without the risk of significant respiratory depression associated with opioid medications. We seek to obtain preliminary data via a clinical trial addressing safety, feasibility, and utility of this novel technique for the treatment of persistent uncontrolled cancer pain. These findings would be an important initial step towards testing the effectiveness of intranasal ketamine as a non-opioid medication for cancer pain
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Xu, Chenjing, Wenyu Jiang, Lu Wang, Xiaqiong Mao, Ziping Ye, and Hongjie Zhang. "Intestinal Ultrasound for Differentiating Fibrotic or Inflammatory Stenosis in Crohn’s disease: A Systematic Review and Meta-analysis." Journal of Crohn's and Colitis, April 7, 2022. http://dx.doi.org/10.1093/ecco-jcc/jjac052.

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Abstract Background and Aims Intestinal ultrasound (IUS) has been increasingly reported to distinguish inflammatory or fibrotic intestinal stenosis in Crohn's disease (CD) patients. However, the diagnostic value is unclear. This systematic review and meta-analysis aimed to assess the diagnostic role of different modes of IUS parameters. Methods We searched PubMed, Embase, Web of Science, and Cochrane Library from inception to August 2021. Regarding effect sizes, weighted mean differences (WMDs) or standardized mean differences (SMDs) were used. We pooled data using a random-effects or fixed-ef
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Chen, Sijing, Jianhong Liu, Shiyi Peng, and Ying Zheng. "LNG-IUS vs. medical treatments for women with heavy menstrual bleeding: A systematic review and meta-analysis." Frontiers in Medicine 9 (August 25, 2022). http://dx.doi.org/10.3389/fmed.2022.948709.

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IntroductionTo compare efficacy and safety of the levonorgestrel-releasing intrauterine system (LNG-IUS) with medical treatments for women with heavy menstrual bleeding.Materials and methodsWe searched PubMed, Embase, the Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure (CNKI), and Wanfang databases for relevant randomized controlled trials (RCTs) in November 2021. All meta-analyses were performed using the random-effects model. PROSPERO registration number: CRD42021295379.ResultsA total of trials (with 14 references) reporting on 1,677 women were include
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de Voogd, F., S. Bots, K. Gecse, O. H. Gilja, G. D’Haens та K. Nylund. "Intestinal ultrasound early on in treatment follow-up predicts endoscopic response to anti-TNFα treatment in Crohn’s Disease". Journal of Crohn's and Colitis, 26 травня 2022. http://dx.doi.org/10.1093/ecco-jcc/jjac072.

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Abstract Background To assess treatment response, objective measures are superior to clinical improvement in Crohn’s Disease (CD). Intestinal ultrasound (IUS) is an attractive, non-invasive alternative to endoscopy demonstrating early transmural changes after treatment initiation. Therefore, we investigated IUS and contrast-enhanced ultrasound (CEUS) to predict (early) endoscopic treatment response. Methods Consecutive patients with endoscopically active CD starting anti-TNFα therapy were included. Clinical, biochemical, IUS and CEUS parameters at baseline (T0), after 4-8 weeks (T1) and 12-34
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