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Artículos de revistas sobre el tema "LC-MS methods"

Autor: Grafiati

Publicado: 10 de marzo de 2023

Última modificación: 31 de julio de 2025

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1

Chikasou, Masato, Syuichi Inohana, Toshiaki Yokozeki, Hitoshi Tuchiya, and Kazuhiro Fujita. "Development of LC-MS and LC-MS/MS Methods for Free Asparagine in Grains." Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) 59, no. 5 (2018): 248–56. http://dx.doi.org/10.3358/shokueishi.59.248.

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2

Kobayashi, Hiroko. "Development of Residue Analysis for Pesticides by LC/MS and LC/MS/MS Methods." BUNSEKI KAGAKU 58, no. 12 (2009): 985–97. http://dx.doi.org/10.2116/bunsekikagaku.58.985.

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3

Viette, Véronique, Denis Hochstrasser, and Marc Fathi. "LC-MS (/MS) in Clinical Toxicology Screening Methods." CHIMIA International Journal for Chemistry 66, no. 5 (2012): 339–42. http://dx.doi.org/10.2533/chimia.2012.339.

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4

Deng, Pan, Yan Zhan, Xiaoyan Chen, and Dafang Zhong. "Derivatization methods for quantitative bioanalysis by LC–MS/MS." Bioanalysis 4, no. 1 (2012): 49–69. http://dx.doi.org/10.4155/bio.11.298.

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5

HAYASHI, Takako, and Kenji HAMASE. "Determination of Clenbuterol in Various Edible Parts of Livestock Products by LC-MS/MS and LC-MS/MS/MS Methods." CHROMATOGRAPHY 42, no. 1 (2021): 43–48. http://dx.doi.org/10.15583/jpchrom.2020.021.

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6

Duggan, Jeffrey, Bailuo Ren, Yan Mao, Lin-Zhi Chen, and Elsy Philip. "LC–MS quantification of protein drugs: validating protein LC–MS methods with predigestion immunocapture." Bioanalysis 8, no. 18 (2016): 1951–64. http://dx.doi.org/10.4155/bio-2016-0137.

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7

Bandar, Ivo Sah, He Sarina Yang, Alex Rai, et al. "Comparison of five tacrolimus measurement methods underscore the need for a standardized method to improve clinical outcomes." American Journal of Clinical Pathology 162, Supplement_1 (2024): S181. http://dx.doi.org/10.1093/ajcp/aqae129.397.

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Abstract Tacrolimus is a widely used drug to prevent post-transplantation organ rejection by suppressing host immune response. While its efficacy is well established, tacrolimus is also known for narrow therapeutic index and debilitating adverse effects, rendering accurate measurement for therapeutic drug monitoring essential, to minimize drug toxicity and graft loss, and maximize organ rejection prevention. Tacrolimus can be quantitated by immunoassay (IA) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). However, previous pairwise studies showed significant inter-assay variabili

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8

Pascale, Michelangelo, Annalisa De Girolamo, Vincenzo Lippolis, Joerg Stroka, Hans G. J. Mol, and Veronica M. T. Lattanzio. "Performance Evaluation of LC-MS Methods for Multimycotoxin Determination." Journal of AOAC International 102, no. 6 (2019): 1708–20. http://dx.doi.org/10.5740/jaoacint.19-0068.

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The co-occurrence of regulated mycotoxins in foods and feeds, together with modified (“masked”) and emerging mycotoxins, has been increasingly reported worldwide in recent years. Therefore, sensitive, accurate, and validated methods for the simultaneous determination of these hazardous contaminants in different matrices are highly demanded to fulfil regulatory requirements and to carry out reliable surveillance programs. In these last years, LC-MS methodologies for multimycotoxin screening and/or quantification are being routinely used in control laboratories. However, to date, only one Europe

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9

Pascale, Michelangelo, Annalisa De Girolamo, Vincenzo Lippolis, Joerg Stroka, Hans G. J. Mol, and Veronica M. T. Lattanzio. "Performance Evaluation of LC-MS Methods for Multimycotoxin Determination." Journal of AOAC INTERNATIONAL 102, no. 6 (2019): 1708–20. http://dx.doi.org/10.1093/jaoac/102.6.1708.

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Abstract The co-occurrence of regulated mycotoxins in foods and feeds, together with modified (“masked”) and emerging mycotoxins, has been increasingly reported worldwide in recent years. Therefore, sensitive, accurate, and validated methods for the simultaneous determination of these hazardous contaminants in different matrices are highly demanded to fulfil regulatory requirements and to carry out reliable surveillance programs. In these last years, LC-MS methodologies for multimycotoxin screening and/or quantification are being routinely used in control laboratories. However, to date, only o

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10

Kalpana, C. Sable* Vinayak M. Gaware Mayur T. Gaikar Vivekanand A. Kashid Jaya V. Mehetre Trupti P. Bhalekar. "A Review On Analytical Methods For Estimation Of Naloxone Hcl And Buprenorphine Hcl In Pharmaceutical Dosage Form." Int. J. in Pharm. Sci. 1, no. 6 (2023): 27–38. https://doi.org/10.5281/zenodo.8028071.

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This review article represents the collection and discussion of various analytical methods available in the literature for the simultaneous estimation of Naloxone and Buprenorphine in pharmaceutical and biological samples consisting of HPLC, UV-visible method, near-IR spectroscopy, spectrofluorometry, and hyphenated techniques such as LC-MS, LC-MS/MS, UPLC-MS/MS, and GC-MS. The anticipated review provides details about the comparative utilization of various analytical techniques for the determination of Naloxone and Buprenorphine. When it comes to offering solutions like development, analytica

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11

Wong, Andrea, Xiaoqiang Xiang, Pei Ong, et al. "A Review on Liquid Chromatography-Tandem Mass Spectrometry Methods for Rapid Quantification of Oncology Drugs." Pharmaceutics 10, no. 4 (2018): 221. http://dx.doi.org/10.3390/pharmaceutics10040221.

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In the last decade, the tremendous improvement in the sensitivity and also affordability of liquid chromatography-tandem mass spectrometry (LC-MS/MS) has revolutionized its application in pharmaceutical analysis, resulting in widespread employment of LC-MS/MS in determining pharmaceutical compounds, including anticancer drugs in pharmaceutical research and also industries. Currently, LC-MS/MS has been widely used to quantify small molecule oncology drugs in various biological matrices to support preclinical and clinical pharmacokinetic studies in R&D of oncology drugs. This mini-review art

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12

Downs, Melanie L., and Philip Johnson. "Target Selection Strategies for LC-MS/MS Food Allergen Methods." Journal of AOAC INTERNATIONAL 101, no. 1 (2018): 146–51. http://dx.doi.org/10.5740/jaoacint.17-0404.

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Abstract The detection and quantitation of allergens as contaminants in foods using MS is challenging largely due to the requirement to detect proteins in complex, mixed, and often processed matrixes. Such methods necessarily rely on the use of proteotypic peptides as indicators of the presence and amount of allergenic foods. These peptides should represent the allergenic food in question in such a way that their use is both sensitive (no false-negatives) and specific (no false-positives). Choosing such peptides to represent food allergens is beset with issues, including, but not limited to, s

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13

Lapko, Veniamin N., Patrick S. Miller, G. Paul Brown, et al. "Sensitive glucagon quantification by immunochemical and LC–MS/MS methods." Bioanalysis 5, no. 23 (2013): 2957–72. http://dx.doi.org/10.4155/bio.13.264.

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14

Vazvaei, Faye, and Jeffrey X. Duggan. "Validation of LC–MS/MS bioanalytical methods for protein therapeutics." Bioanalysis 6, no. 13 (2014): 1739–42. http://dx.doi.org/10.4155/bio.14.125.

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15

Naidong, Weng, Yu-Luan Chen, Wilson Shou, and Xiangyu Jiang. "Importance of injection solution composition for LC–MS–MS methods." Journal of Pharmaceutical and Biomedical Analysis 26, no. 5-6 (2001): 753–67. http://dx.doi.org/10.1016/s0731-7085(01)00439-3.

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16

Zelzer, Sieglinde, Caroline Le Goff, Stéphanie Peeters, et al. "Comparison of two LC-MS/MS methods for the quantification of 24,25-dihydroxyvitamin D3 in patients and external quality assurance samples." Clinical Chemistry and Laboratory Medicine (CCLM) 60, no. 1 (2021): 74–81. http://dx.doi.org/10.1515/cclm-2021-0792.

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Abstract Objectives In-house developed liquid-chromatography mass spectrometry (LC-MS/MS) methods are used more and more frequently for the simultaneous quantification of vitamin D metabolites. Among these, 24,25-dihydroxyvitamin D3 (24,25(OH)2D3) is of clinical interest. This study assessed the agreement of this metabolite in two validated in-house LC-MS/MS methods. Methods 24,25(OH)2D3 was measured in 20 samples from the vitamin D external quality assurance (DEQAS) program and in a mixed cohort of hospital patients samples (n=195) with the LC-MS/MS method at the Medical University of Graz (L

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17

Obeid, Rima, Jürgen Geisel, and Wolfgang Herrmann. "Comparison of two methods for measuring methylmalonic acid as a marker for vitamin B12 deficiency." Diagnosis 2, no. 1 (2015): 67–72. http://dx.doi.org/10.1515/dx-2014-0030.

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AbstractMethylmalonic acid (MMA) is a functional marker of vitamin B12 status and a valuable diagnostic tool. The gas chromatography mass spectrometry (GCMS) MMA assay has been used for decades in clinical studies.In this study, we compared a newly developed liquid chromatography tandem mass spectrometry assay for MMA (ClinMassThe GCMS and LC-MS/MS assays showed a strong correlation (r=0.92, p<0.001) particularly at low holoTC levels (deficiency is more probable). Forty six cases had MMA>300 nmol/L with both methods. Only five subjects showed MMA GCMS>300 nmol/L, but MMA LC-MS/MS≤300

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18

Sun, Yuanxin. "Methods to Reduce Matrix Effect Corresponding to Different Methods." Theoretical and Natural Science 4, no. 1 (2023): 365–69. http://dx.doi.org/10.54254/2753-8818/4/20220592.

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In this paper, LC-MS / MS is the main technology used to detect the toxins that cause diarrhea shellfish poisoning in shellfish toxins, including okadaic acid (OA) or its analogues, the dynophysistoxins (DTXds), spectenotoxin (PTX), yessotoxin and its derivatives (YTX) and azaspiracid (AZA). It is mainly found that when analyzing drugs in biological samples based on LC-MS / MS, Some extracts in the sample may affect the ionization efficiency of the target compound and thus affect the detection results, especially phospholipids. Based on the efforts made and innovative methods provided by other

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19

Akbaba, Murat, and Aysun Baransel Isir. "Concordance of Biochip-Based and LC-MS/MS Methods in Urine and Blood Samples in Screening for Amphetamine and Methamphetamine." Diagnostics 15, no. 3 (2025): 269. https://doi.org/10.3390/diagnostics15030269.

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Objectives: This study aimed to evaluate the efficacy and reliability of LC-MS/MS and biochip-based screening in detecting narcotics from blood and urine samples. Materials and Methods: In this single-center study, a total of 250 subjects provided urine and/or blood samples: 234 provided urine and blood samples, and 16 provided only blood samples. Biochip-based narcotics screening was performed on 234 urine and 16 blood samples, and all samples were analyzed using tandem liquid chromatography-mass spectrometry (LC-MS/MS). Results: The two most prevalent narcotics were methamphetamine and amphe

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20

Lee, Ji Hyun, Han Na Park, Hyoung-Joon Park, et al. "Development and Validation of LC–MS/MS and LC-Q-Orbitrap/MS Methods for Determination of Glyphosate in Vaccines." Chromatographia 80, no. 12 (2017): 1741–47. http://dx.doi.org/10.1007/s10337-017-3417-9.

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21

Tokumura, Masahiro, Yuichi Miyake, Qi Wang, et al. "Methods for the analysis of organophosphorus flame retardants—Comparison of GC-EI-MS, GC-NCI-MS, LC-ESI-MS/MS, and LC-APCI-MS/MS." Journal of Environmental Science and Health, Part A 53, no. 5 (2018): 475–81. http://dx.doi.org/10.1080/10934529.2017.1410419.

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22

Mahabee-Gittens, E. Melinda, Matthew J. Mazzella, John T. Doucette, et al. "Comparison of Liquid Chromatography Mass Spectrometry and Enzyme-Linked Immunosorbent Assay Methods to Measure Salivary Cotinine Levels in Ill Children." International Journal of Environmental Research and Public Health 17, no. 4 (2020): 1157. http://dx.doi.org/10.3390/ijerph17041157.

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Objective: Cotinine is the preferred biomarker to validate levels of tobacco smoke exposure (TSE) in children. Compared to enzyme-linked immunosorbent assay methods (ELISA) for quantifying cotinine in saliva, the use of liquid chromatography tandem mass spectrometry (LC-MS/MS) has higher sensitivity and specificity to measure very low levels of TSE. We sought to compare LC-MS/MS and ELISA measures of cotinine in saliva samples from children overall and the associations of these measures with demographics and TSE patterns. Method: Participants were nonsmoking children (N = 218; age mean (SD) =

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23

Al-Neaimy, Usra Ibrahim Saeed, Zainab Faiyq Saeed, and Sahar Mahmood Shehab. "A Review on Analytical Methods for Piperazine Determination." NTU Journal of Pure Sciences 1, no. 3 (2022): 1–9. http://dx.doi.org/10.56286/ntujps.v1i3.230.

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Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. It is an anthelmintic drug in human as well as in veterinary medicine. This review article represent the various analytical methods which has been reported for estimation of piperazine. The colorimetric , spectrophotometric techniques and chromatographic methods like HPLC and RP HPLC, GC, LC-MS, LC-MS/MS and another methods were reported.

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24

HESS, P., E. MCGOVERN, T. MCMAHON, et al. "LC-UV and LC-MS methods for the determination of domoic acid." TrAC Trends in Analytical Chemistry 24, no. 4 (2005): 358–67. http://dx.doi.org/10.1016/j.trac.2004.11.019.

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25

Kirtimaya, Mishra* Dr. K. Balamurugan1 Dr. R. Suresh1. "A REVIEW: AN APPROACH TOWARDS THE ANALYTICAL METHOD DEVELOPMENT FOR DETERMINATION OF NEWER DRUGS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 01 (2017): 7353–60. https://doi.org/10.5281/zenodo.1006749.

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In this present scenario for treating various diseases several new drugs were invented. Before launching to the market these drugs must undergo analytical validation process. In this review some of analytical techniques such as ultraviolet/ visible spectrophotometry, fluorimetry, capillary electrophoresis, and chromatographic methods (gas chromatography and high-performance liquid chromatography), LC-MS, GC-MS, SOLID PHASE EXTRACTION, NMR, MASS Spectrophotometry LC/MS/MS LC/UV X-ray crystallography were discussed.

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26

Sherma, Joseph. "High-Performance Liquid Chromatography/Mass Spectrometry Analysis of Botanical Medicines and Dietary Supplements: A Review." Journal of AOAC INTERNATIONAL 86, no. 5 (2003): 873–81. http://dx.doi.org/10.1093/jaoac/86.5.873.

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Abstract This article reviews research on the qualitative and quantitative analysis by high-performance column liquid chromatography/mass spectrometry (LC/MS) and LC/tandem mass spectrometry (LC/MS/MS) of botanical drugs, drug substances or preparations, and finished botanical products. In addition, LC/MS and LC/MS/MS techniques and commercial instruments are described and compared briefly, and prospects for future use of these methods for the analysis of botanicals are suggested. Some applications of direct MS without LC are also described.

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27

Sharma, Kuldeep, and Ramesh Mullangi. "A concise review of HPLC, LC-MS and LC-MS/MS methods for determination of azithromycin in various biological matrices." Biomedical Chromatography 27, no. 10 (2013): 1243–58. http://dx.doi.org/10.1002/bmc.2898.

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28

Lim, Chee Wei, Gerald Chung, and Sheot Harn Chan. "Analytical Methods for Mycotoxin Detection in Southeast Asian Nations (ASEAN)." Journal of AOAC INTERNATIONAL 101, no. 3 (2018): 613–17. http://dx.doi.org/10.5740/jaoacint.17-0335.

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Abstract Aflatoxins B1 (AFB1) and B2 (AFB2) and G1 and G2 remain the top mycotoxins routinely analyzed and monitored by Association of Southeast Asian Nations (ASEAN) national laboratories primarily for food safety regulation in the major food commodities, nuts and spices. LC tandem fluorescence detection (LC–fluorescence) represents a current mainstream analytical method, with a progressive migration to a primary method by LC tandem MS (MS/MS) for the next half decade. Annual proficiency testing (PT) is conducted by ASEAN Food Reference Laboratories (AFRLs) for mycotoxin testing as part of ca

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29

Babić, Nikolina. "Analytical methods and performance of the immunoassay methods for determination of vitamin d in comparison to mass spectrometry / Analitičke metode i izvođenje imunometrijskih određivanja vitamina d u poređenju sa masenom spektrometrijom." Journal of Medical Biochemistry 31, no. 4 (2012): 333–38. http://dx.doi.org/10.2478/v10011-012-0022-1.

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Summary Demand for vitamin D testing has been on a constant rise worldwide, partially due to mounting evidence linking vitamin D status to overall health and well-being. Currently available assays measure 25-hydroxy vitamin D (25-OHD), a major circulating form of vitamin D. Available methodologies include immunoassays and mass spectrometry based methods (LC-MS/MS). Until recently, the only immunoassays available for diagnostic use in the US have been DiaSorin radioimmunoassay (RIA) and an automated immunoassay on a LIAISON® platform. Within the last year, Siemens and Abbott successfully launch

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30

Sun, Yuchen, Shin-ichiro Nitta, Kosuke Saito, et al. "Development and multicenter validation of an LC–MS-based bioanalytical method for antisense therapeutics." Bioanalysis 14, no. 18 (2022): 1213–27. http://dx.doi.org/10.4155/bio-2022-0126.

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Background: Many bioanalytical methods for antisense oligonucleotides (ASOs) using LC–MS have been reported. However, no data have been available on the reproducibility and robustness of a single bioanalytical method for ASOs. As such, in the current study, we evaluated the reproducibility and robustness of LC–MS-based bioanalytical methods for ASOs in multiple laboratories. Methods/Results: Seven independent laboratories were included in this study. Mipomersen was measured by ion-pairing LC–MS (IP-LC–MS) as a model ASO using different LC–MS. The validation results of calibration curve, accura

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31

Radović, Radmila, Bojana Radić, Sanja Đekić, Sanja Belić, and Jovana Kos. "State-of-the-art mycotoxin analysis: Insights from LC/MS-MS method." Food and Feed Research, no. 00 (2025): 73. https://doi.org/10.5937/ffr0-55401.

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Mycotoxins are secondary metabolites produced by fungi, known for their chemical and thermal stability, which makes them resistant to common food and feed processing methods. These toxins can contaminate food and feed, and cause a range of toxic effects upon ingestion, including mutagenic, teratogenic, carcinogenic, immunotoxic, neurotoxic, hepatotoxic, and dermatotoxic effects. In recent years, the application of liquid chromatography combined with tandem mass spectrometry has grown significantly for mycotoxin analysis, owing to its remarkable sensitivity and specificity. Recent literature hi

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32

Gill, Brendon D., Harvey E. Indyk, Tadashi Kobayashi, Iain J. McGrail, and David C. Woollard. "Comparison of LC-MS/MS and Enzymatic Methods for the Determination of Total Choline and Total Carnitine in Infant Formula and Milk Products." Journal of AOAC INTERNATIONAL 103, no. 5 (2020): 1293–300. http://dx.doi.org/10.1093/jaoacint/qsaa060.

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Abstract Background Choline and l-carnitine are classified as pseudo-vitamins because of their conditionally essential status. As they are involved in multiple physiological metabolic pathways in the human body, they are routinely fortified in infant and adult nutritional formulas. Objective The performance of an LC-MS/MS method for the analysis of choline and carnitine, compared with enzymatic methods in routine use for the analysis of total carnitine and total choline, is described. Method Powder samples were reconstituted, with release of carnitine and choline facilitated by both acid and a

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Yun, Jisuk, Jinyoung Kim, Jangduck Choi, Kisung Kwon, and Cheon-Ho Jo. "Simultaneous determination of Phlomis umbrosa and Dipsacus asperoides in foods using LC-MS/MS methods." Korean Journal of Food Science and Technology 48, no. 6 (2016): 531–35. http://dx.doi.org/10.9721/kjfst.2016.48.6.531.

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34

Büttler, Rahel M., Frans Martens, Flaminia Fanelli, et al. "Comparison of 7 Published LC-MS/MS Methods for the Simultaneous Measurement of Testosterone, Androstenedione, and Dehydroepiandrosterone in Serum." Clinical Chemistry 61, no. 12 (2015): 1475–83. http://dx.doi.org/10.1373/clinchem.2015.242859.

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Abstract BACKGROUND Recently, LC-MS/MS was stated to be the method of choice to measure sex steroids. Because information on the mutual agreement of LC-MS/MS methods is scarce, we compared 7 published LC-MS/MS methods for the simultaneous measurement of testosterone, androstenedione, and dehydroepiandrosterone (DHEA). METHODS We used 7 published LC-MS/MS methods to analyze in duplicate 55 random samples from both men and women. We performed Passing–Bablok regression analysis and calculated Pearson correlation coefficients to assess the agreement of the methods investigated with the median conc

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Vogeser, Michael, and Christoph Seger. "Pitfalls Associated with the Use of Liquid Chromatography–Tandem Mass Spectrometry in the Clinical Laboratory." Clinical Chemistry 56, no. 8 (2010): 1234–44. http://dx.doi.org/10.1373/clinchem.2009.138602.

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BACKGROUND Novel mass spectrometric techniques such as atmospheric pressure ionization and tandem mass spectrometry have substantially extended the spectrum of clinical chemistry methods during the past decade. In particular, liquid chromatography tandem–mass spectrometry (LC-MS/MS) has become a standard tool in research laboratories as well as in many clinical laboratories. Although LC-MS/MS has features that suggest it has a very high analytical accuracy, potential sources of inaccuracy have recently been identified. CONTENT The sources of inaccuracy in LC-MS/MS methods used in the routine q

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HIRAOKA, Kenzo. "Development of New Ionization Methods for GC/MS and LC/MS Interfaces." Journal of the Mass Spectrometry Society of Japan 53, no. 2 (2005): 60–78. http://dx.doi.org/10.5702/massspec.53.60.

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Nel, Andrew J. M., Shaun Garnett, Jonathan M. Blackburn, and Nelson C. Soares. "Comparative Reevaluation of FASP and Enhanced FASP Methods by LC–MS/MS." Journal of Proteome Research 14, no. 3 (2015): 1637–42. http://dx.doi.org/10.1021/pr501266c.

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Heath, D. D., S. W. Flatt, A. H. B. Wu, M. A. Pruitt, and C. L. Rock. "Evaluation of Tamoxifen and Metabolites by LC-MS/MS and HPLC Methods." British Journal of Biomedical Science 71, no. 1 (2014): 33–39. http://dx.doi.org/10.1080/09674845.2014.11669960.

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W, Brown N., Gonde C. E, Adams J. E, and Tredger J. M. "The Clinical Advantages of LC-MS/MS Over Meia Methods for Tacrolimus." Therapeutic Drug Monitoring 27, no. 2 (2005): 214. http://dx.doi.org/10.1097/00007691-200504000-00030.

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Jenkins, Rand, Jeffrey X. Duggan, Anne-Françoise Aubry, et al. "Recommendations for Validation of LC-MS/MS Bioanalytical Methods for Protein Biotherapeutics." AAPS Journal 17, no. 1 (2014): 1–16. http://dx.doi.org/10.1208/s12248-014-9685-5.

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Wang, J., D. Yan, A. Zhao, et al. "Discovery of potential biomarkers for osteoporosis using LC-MS/MS metabolomic methods." Osteoporosis International 30, no. 7 (2019): 1491–99. http://dx.doi.org/10.1007/s00198-019-04892-0.

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Mellon, Fred A., Richard N. Bennett, Birgit Holst, and Gary Williamson. "Intact Glucosinolate Analysis in Plant Extracts by Programmed Cone Voltage Electrospray LC/MS: Performance and Comparison with LC/MS/MS Methods." Analytical Biochemistry 306, no. 1 (2002): 83–91. http://dx.doi.org/10.1006/abio.2002.5677.

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Lee, Seung Won, Ji You Kim, Seon Hwa Kim, Hyung Wook Jo, Joon Kwan Moon, and In Seon Kim. "Monitoring of Diquat and Paraquat in Livestock Products by LC-MS/MS Combined with Modified QuEChERS Methods." Korean Journal of Environmental Agriculture 44 (2025): 110–20. https://doi.org/10.5338/kjea.2025.44.12.

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Malesevic, M., L. Zivanovic, A. Protic, et al. "Stress degradation studies on zolpidem tartrate using LC-DAD and LC-MS methods." Acta Chromatographica 26, no. 1 (2014): 81–96. http://dx.doi.org/10.1556/achrom.26.2014.1.8.

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Zhang, Kai. "Comparison of Flow Injection-MS/MS and LC-MS/MS for the Determination of Ochratoxin A." Toxins 13, no. 8 (2021): 547. http://dx.doi.org/10.3390/toxins13080547.

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Two methods for measuring ochratoxin A in corn, oat, and grape juice were developed and compared. Flow injection (FI) and on-line liquid chromatography (LC) performances were evaluated separately, with both methods using a triple quadrupole tandem mass spectrometer (MS/MS) for quantitation. Samples were fortified with 13C uniformly labeled ochratoxin A as the internal standard (13C-IS) and prepared by dilution and filtration, followed by FI- and LC-MS/MS analysis. For the LC-MS/MS method, which had a 10 min run time/sample, recoveries of ochratoxin A fortified at 1, 5, 20, and 100 ppb in corn,

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Dewi, Kifayati Rosiyanti, Feri Kusnandar, Nancy Dewi Yuliana, et al. "Application of LC-MS/MS Coupled with Various Digestion Methods for the Identification of Porcine Gelatin Markers in Confectionery Matrices." Indonesian Journal of Halal Research 5, no. 2 (2023): 53–66. http://dx.doi.org/10.15575/ijhar.v5i2.21191.

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Gelatin is a high-risk ingredient in terms of its halal status. Liquid chromatography combined with mass spectrometry (LC-MS/MS) was used to identify the source of gelatin based on marker peptides and proved to deliver higher reliability than other methods. However, the digestion method is essential before LC-MS/MS analysis. This research evaluated different digestion methods against selected porcine gelatin marker peptides and assessed LC-MS/MS sensitivity through adulteration experiments in various mixed matrices. The study involved three digestion methods (conventional, microwave, and ultra

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Kushnir, Mark M., Alan L. Rockwood, Frederick G. Strathmann, Elizabeth L. Frank, Joely A. Straseski, and A. Wayne Meikle. "LC-MS/MS Measurement of Parathyroid Hormone–Related Peptide." Clinical Chemistry 62, no. 1 (2016): 218–26. http://dx.doi.org/10.1373/clinchem.2015.244012.

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Abstract INTRODUCTION Parathyroid hormone–related peptide (PTHrP) is involved in activating pathways, allowing tumor cells to form bone metastases. Measurement of PTHrP is used for the diagnosis and clinical management of patients suspected of hypercalcemia of malignancy. We developed an LC-MS/MS method for measuring PTHrP, established sex-specific reference intervals, and assessed the method's performance. METHODS PTHrP was enriched from plasma samples with rabbit polyclonal anti-PTHrP antibody conjugated to magnetic beads. Enriched PTHrP was digested with trypsin, and PTHrP-specific tryptic

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Montagna, Giacomo, Samuela Balestra, Federica D’Aurizio, et al. "Establishing normal values of total testosterone in adult healthy men by the use of four immunometric methods and liquid chromatography-mass spectrometry." Clinical Chemistry and Laboratory Medicine (CCLM) 56, no. 11 (2018): 1936–44. http://dx.doi.org/10.1515/cclm-2017-1201.

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Abstract Background: The total testosterone (T) cutoffs clinically adopted to define late-onset hypogonadism (LOH) do not consider the differences that exist between different analytical platforms, nor do they consider the body mass index (BMI) or age of the patient. We aimed at providing method, age and BMI-specific normal values for total T in European healthy men. Methods: A total of 351 eugonadal healthy men were recruited, and total T was measured with four automated immunometric assays (IMAs): ARCHITECT i1000SR (Abbott), UniCel DxI800 (Beckman Coulter), Cobas e601 (Roche), IMMULITE 2000

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Sharma, Hemraj, Hari Prasad Sapkota, and Nim Bahadur Dangi. "A Brief Review of Analytical Methods for the Estimation of Allopurinol in Pharmaceutical Formulation and Biological Matrices." International Journal of Analytical Chemistry 2021 (June 5, 2021): 1–12. http://dx.doi.org/10.1155/2021/5558651.

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This review article represents the collection and discussion of various analytical methods available in the literature for the determination of allopurinol (ALLP) in pharmaceutical and biological samples consisting of HPLC, UV-visible method, near-IR spectroscopy, spectrofluorometry, capillary electrophoresis, polarography, voltammetry, and hyphenated techniques such as LC-MS, LC-MS/MS, UPLC-MS/MS, and GC-MS. The anticipated review provides details about the comparative utilization of various analytical techniques for the determination of ALLP. The present review article can be effectively exp

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Zhu, Yunting, Pan Deng, and Dafang Zhong. "Derivatization methods for LC–MS analysis of endogenous compounds." Bioanalysis 7, no. 19 (2015): 2557–81. http://dx.doi.org/10.4155/bio.15.183.

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