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1
Williams, Patrick. "Lerma, Old Castile and the Travels of Philip III of Spain". History 73, n.º 239 (octubre de 1988): 379–97. http://dx.doi.org/10.1111/j.1468-229x.1988.tb02158.x.
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Abrahao, R., J. Causapé, I. García-Garizábal y D. Merchán. "Implementing irrigation: Salt and nitrate exported from the Lerma basin (Spain)". Agricultural Water Management 102, n.º 1 (diciembre de 2011): 105–12. http://dx.doi.org/10.1016/j.agwat.2011.10.011.
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Abrahao, R., J. Causapé, I. García-Garizábal y D. Merchán. "Implementing irrigation: Water balances and irrigation quality in the Lerma basin (Spain)". Agricultural Water Management 102, n.º 1 (diciembre de 2011): 97–104. http://dx.doi.org/10.1016/j.agwat.2011.10.010.
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Dadson, Trevor J. "The Duke of Lerma and the Count of Salinas: Politics and Friendship in Early Seventeenth-Century Spain". European History Quarterly 25, n.º 1 (enero de 1995): 5–38. http://dx.doi.org/10.1177/026569149502500101.
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Franganillo Álvarez, Alejandra. "Patronage and Power: The Vicereines at the Court of Naples in the Reign of Philip III of Spain". Renaissance and Reformation 43, n.º 4 (15 de abril de 2021): 149–70. http://dx.doi.org/10.33137/rr.v43i4.36386.
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Recently, several studies have focused on the figure of the viceroy in the Spanish Monarchy, especially in the Kingdom of Naples. However, far less attention has been paid to the role of the vicereines of Naples. The goal of my study is to investigate and clarify the significant roles held by these noblewomen at one of the most important viceregal courts of the Spanish Monarchy. I will focus on one vicereine in particular, Catalina de Zúñiga y Sandoval, 6th Countess of Lemos and sister to the Duke of Lerma (1599–1601), who developed an extensive political network through copious correspondences, requesting and distributing mercedes (dignities and favours) among family members and her clientage. A revisionary analysis of the vicereines’ roles at the Neapolitan court demonstrates how knowledge of their political contribution is essential for a deeper understanding of the economic and political strategies deployed by their families.
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Cairns, Graham y Rachel Isaac-Menard. "TheDuke of Lerma, Equestrianas a Roman Imperial Image in the Court of Philip III of Spain: A Historiographical Reappraisal". Konsthistorisk Tidskrift/Journal of Art History 82, n.º 2 (junio de 2013): 81–98. http://dx.doi.org/10.1080/00233609.2013.787119.
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Elliott, J. H. "The Great Favourite: The Duke of Lerma and the Court and Government of Philip III of Spain, 1598-1621". English Historical Review CXXIII, n.º 500 (1 de febrero de 2008): 201–2. http://dx.doi.org/10.1093/ehr/cem447.
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Patiño-Loira, Javier. "“Meddling with Royal Hearts”: Interiority and Privanza (1598-1643)". Culture & History Digital Journal 6, n.º 2 (29 de noviembre de 2017): 017. http://dx.doi.org/10.3989/chdj.2017.017.
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This paper studies how seventeenth-century writers in Spain elaborated different conceptions of interiority in connection with the intimacy they imagined between the king and his favorite or privado. Authors in the days of Lerma, Uceda and Olivares portrayed the relation between king and privado in terms that generally relied on inherited notions of ideal friendship, which nonetheless would clash with concerns about the ubiquity of deceit, simulation and dissimulation at the court. This seemed to set boundaries to the unlimited transparency and trust expected between friends. I will address three issues. First, the way writers imagine the favorite’s access to the king’s secrets, as well as the nature of these secrets. Second, the space of intimacy and shared loneliness in which they conceive the friendship of king and privado to materialize. Third, the transformations that take place in the favorite’s interiority as a result of his relation with the king and his position at the court.
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Merchán, D., N. Otero, A. Soler y J. Causapé. "Main sources and processes affecting dissolved sulphates and nitrates in a small irrigated basin (Lerma Basin, Zaragoza, Spain): Isotopic characterization". Agriculture, Ecosystems & Environment 195 (octubre de 2014): 127–38. http://dx.doi.org/10.1016/j.agee.2014.05.011.
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Merchán, D., J. Causapé, R. Abrahão y I. García-Garizábal. "Assessment of a newly implemented irrigated area (Lerma Basin, Spain) over a 10-year period. II: Salts and nitrate exported". Agricultural Water Management 158 (agosto de 2015): 288–96. http://dx.doi.org/10.1016/j.agwat.2015.04.019.
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Merchán, D., J. Causapé, R. Abrahão y I. García-Garizábal. "Assessment of a newly implemented irrigated area (Lerma Basin, Spain) over a 10-year period. I: Water balances and irrigation performance". Agricultural Water Management 158 (agosto de 2015): 277–87. http://dx.doi.org/10.1016/j.agwat.2015.04.016.
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FEROS, ANTONIO. "The Great Favourite: The Duke of Lerma and the Court and Government of Philip III of Spain, 1598–1621 By Patrick Williams". History 93, n.º 310 (abril de 2008): 267–68. http://dx.doi.org/10.1111/j.1468-229x.2008.423_13.x.
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Valverde Larrosa, Consuelo y Juan Carlos Martín García. "Estudios radiográficos de tres de los grandes Cristos de caña de maíz identificados en España: el Cristo crucificado de Lerma (Burgos), el Cristo de Santa María de Vitoria-Gasteiz (Álava) y el Cristo de la buena muerte de Gran Canaria (Gran Canaria)". Intervención Revista Internacional de Conservación Restauración y Museología 1, n.º 1 (1 de mayo de 2010): 39–52. http://dx.doi.org/10.30763/intervencion.2015.12.144.
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Schönhofer, Axel L. y Jochen Martens. "Revision of the genus Trogulus Latreille: the Trogulus coriziformis species-group of the western Mediterranean (Opiliones:Trogulidae)". Invertebrate Systematics 22, n.º 5 (2008): 523. http://dx.doi.org/10.1071/is08013.
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Within the well researched European fauna of harvestmen, the genus Trogulus Latreille exhibits unexpectedly high cryptic diversity. The species’ uniform morphology hinders an exclusively morphological approach to their systematics and taxonomy, and a preliminary molecular study estimated the number of species to be three times higher than currently known. The current study focuses on a clearly defined species-group within Trogulus, combining molecular (~1700 bp 28S rRNA and the cytochrome b gene), distributional, morphometric and morphological data. Relationships are reconstructed using Bayesian inference, maximum parsimony and maximum likelihood and this information is subsequently used to evaluate morphological characters for systematic usability and to identify biogeographical processes leading to speciation events. The Trogulus coriziformis species-group is defined and diagnosed and includes eight species. Three species are redefined: T. coriziformis C. L. Koch, 1839, for which a neotype is designated, and T. aquaticus Simon, 1879 and T. cristatus Simon, 1879 for which lectotypes are designated. Four species are described as new: T. balearicus, sp. nov. from the Balearic Islands, T. huberi, sp. nov. from southern Portugal, T. prietoi, sp. nov. from Andalusia, Spain, and T. pyrenaicus, sp. nov. from the central Pyrenees. Trogulus lusitanicus Giltay, 1931 is used as collective name and probably refers to a composite of species presently difficult to tell apart. Trogulus salfii De Lerma, 1948 is proposed as a synonym for T. coriziformis. Within Trogulus, the molecular genetic data support monophyly and basal placement of the Trogulus coriziformis species-group. The species to differ in external morphology (size, papillation of palps, apophyses of legs, pattern of body papillation, morphometric data), 28S and cytochrome b autapomorphies and to a lesser degree by male genital morphology. The species-group is confined to the western Mediterranean area and its species are allopatrically distributed. Their present distribution corresponds to geological processes in the Miocene and Pliocene indicating that this group of organisms may be of considerable value for further biogeographic studies.
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Lerma, J. J., A. Gracia, A. Perez, A. Rueda, C. Molina, M. D. Pastor, I. Balaguer Trull et al. "AB0698 REAL CLINICAL PRACTICE IN THE CONTROL OF REPORTED OUTCOMES BY THE PATIENT (PROS) DIAGNOSED WITH PSORIATIC ARTHRITIS AND/OR ANKYLOSING SPONDYLITIS WHO BEGIN TREATMENT WITH SECUKINUMAB. A PROSPECTIVE MULTICENTRIC STUDY." Annals of the Rheumatic Diseases 79, Suppl 1 (junio de 2020): 1645.1–1645. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2795.
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Background:Objectives:Analyse the effect of secukinumab in terms of the patient´s own variables, specifically: fatigue, sleep, pain and quality of life in patients with psoriatic arthritis or spondyloarthritis.Methods:A multicentric longtitudinal observational prospective study was carried out at 6 months in patients who begin treatment with secukinumab. At the start and after 6 months the following data was collected on the outcome: pain through an visual analogue scale (VAS), fatigue using the FACIT-fatigue scale, sleeping problems using the insomnia severity index (ISI) and quality of life with the EuroQol-3L-5D and the PsAQoL.The sample can be described in terms of the distribution of the variables through measures of central tendency.It was analysed if the change after 6 months was statistically relevant using Student´s t-test for paired data in the case of FACIT, VAS, PsAQoL and ISI and chi-squared for the dimensions of the EQ-5D. The size of the effect of each of the measurements taken was calculated using Cohen’s D. the results are given grouped by disease and globally. The analysis was carried out using Stata v12 (College Station Tx, USA)Results:In table 1, the changes in the scales of normal distribution can be seen. Apart from general VAS, all the scales experience significant relevant changes. The PROs preferred by the patient with the best therapeutic response is the quality of sleep. The adjustment of the regression models does not produce changes in the results, apart from small adjustments to the condidence intervals (final column table 1). The subdomain in which the most significant change in the EQ-5D is produced is in that of pain and discomfort.Conclusion:After 6 months patients who begin treatment with secukinumab, present with improvements in all sizes of the effects of the treatment in the various studied scales. The improvement achieves global and generalised statistical significance after 6 months of study. The greatest effect is on sleep, quality of life and fatigue.The measurements of the outcomes reported by the patients are a clinical value added to our objective evaluations of the health and activity of the disease, and allow us, in a more integrated and comprehensive manner, to undertake a more exact and close evaluation of their state of health and wellbeing.Disclosure of Interests:JUAN JOSE LERMA: None declared, Antonio Gracia: None declared, Antonio Perez: None declared, Amalia Rueda: None declared, Clara Molina: None declared, M. Dolores Pastor: None declared, Isabel Balaguer Trull: None declared, Inmaculada Valiente: None declared, Cristina Campos Fernández: None declared, Javier Calvo: None declared, Loreto Carmona Grant/research support from: Novartis Farmaceutica, SA, Pfizer, S.L.U., Merck Sharp & Dohme España, S.A., Roche Farma, S.A, Sanofi Aventis, AbbVie Spain, S.L.U., and Laboratorios Gebro Pharma, SA (All trhough institution)
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Gupta, Ankit y Ratna Dev Sarma. "A uniform approach to normality for topological spaces". Applied General Topology 17, n.º 1 (11 de abril de 2016): 7. http://dx.doi.org/10.4995/agt.2016.3919.
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<pre><span>$(\lambda, \mu)$</span>-regularity and <span>$(\lambda, \mu)$</span>-normality are defined for generalized topological spaces. Several variants of normality existing in the literature turn out to be particular cases of <span>$(\lambda, \mu)$</span>-normality. <span>Uryshon's</span> lemma and <span>Titze's</span> extension theorem are discussed in the light of (<span>$\lambda, \mu$</span>)-normality.</pre><pre> </pre>
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Rawlings, Helen. "The great favourite. The duke of Lerma and the court and government of Philip III of Spain, 1598–1621. By Patrick Williams. (Studies in Early Modern European History.) Pp. xxix + 303 incl. 3 genealogical tables and 7 tables. Manchester–New York: Manchester University Press, 2006. £65. 0 7190 5137 1; 978 0 7190 5137 1". Journal of Ecclesiastical History 59, n.º 3 (julio de 2008): 560–61. http://dx.doi.org/10.1017/s0022046908005010.
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Lees, Benjamin y Lorenzo Taggi. "Exponential decay of transverse correlations for O(N) spin systems and related models". Probability Theory and Related Fields 180, n.º 3-4 (28 de abril de 2021): 1099–133. http://dx.doi.org/10.1007/s00440-021-01053-5.
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AbstractWe prove exponential decay of transverse correlations in the Spin O(N) model for arbitrary non-zero values of the external magnetic field and arbitrary spin dimension $$N > 1$$ N > 1 . Our result is new when $$N > 3$$ N > 3 , in which case no Lee–Yang theorem is available, it is an alternative to Lee–Yang when $$N = 2, 3$$ N = 2 , 3 , and also holds for a wide class of multi-component spin systems with continuous symmetry. The key ingredients are a representation of the model as a system of coloured random paths, a ‘colour-switch’ lemma, and a sampling procedure which allows us to bound from above the ‘typical’ length of the open paths.
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DE ROECK, W., CHRISTIAN MAES, KAREL NETOČNÝ y LUC REY-BELLET. "A NOTE ON THE NON-COMMUTATIVE LAPLACE–VARADHAN INTEGRAL LEMMA". Reviews in Mathematical Physics 22, n.º 07 (agosto de 2010): 839–58. http://dx.doi.org/10.1142/s0129055x10004089.
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We continue the study of the free energy of quantum lattice spin systems where to the local Hamiltonian H an arbitrary mean field term is added, a polynomial function of the arithmetic mean of some local observables X and Y that do not necessarily commute. By slightly extending a recent paper by Hiai, Mosonyi, Ohno and Petz [10], we prove in general that the free energy is given by a variational principle over the range of the operators X and Y. As in [10], the result is a non-commutative extension of the Laplace–Varadhan asymptotic formula.
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del Moral, M. B. Garcia, M. P. Jimenez Tejada, L. F. Garcia del Moral, J. M. Ramos, F. Roca de Togores y J. L. Molina-Cano. "Apex and ear development in relation to the number of grains on the main-stem ears in spring barley (Hordeum distichon)". Journal of Agricultural Science 117, n.º 1 (agosto de 1991): 39–45. http://dx.doi.org/10.1017/s0021859600078941.
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SUMMARYApex and ear development in nine spring barley genotypes were studied at two sites in southern Spain in 1988. The genotypes were grouped into medium and early types, depending on the time from sowing to anthesis. Medium genotypes had significantly more spikelet primordia than early ones at both sites. Spikelet mortality was similar between genotypes and sites, resulting in a higher final number of grains/ear in the medium than the early genotypes.There was a positive correlation between the maximum number of spikelet primordia and the duration of three stages of apical development: lemma-, stamen- and awn-primordia. Negative correlations were observed between spikelet mortality and the duration of certain developmental phases of the ear.
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Ammari, Rachid y Lahbib Zenkouar. "Amazigh-Sys: Intelligent system for recognition of amazigh words". IAES International Journal of Artificial Intelligence (IJ-AI) 10, n.º 2 (1 de junio de 2021): 482. http://dx.doi.org/10.11591/ijai.v10.i2.pp482-489.
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<span id="docs-internal-guid-0264fec3-7fff-a3e5-94ef-c25bcfddc65d"><span>Amazigh-sys is an intelligent morphological analysis system for Amazigh language based on xerox’s finite-state transducer (XFST). Our system can process simultaneously five lexical units. This paper begins with the development of Amazigh lexicon (AMAlex) for attested nouns, verbs, pronouns, prepositions, and adverbs and the characteristics relating to each lemma. A set of rules are added to define the inflectional behavior and morphosyntactic links of each entry as well as the relationship between the different lexical units. The use of finite-state technology ensures the bidirectionality of our system (analysis and generation). Amazigh-sys is the first general morphological analysis system for Amazigh based on xerox finite state able to process and recognize all lexical units and ensures a high recognition rate of input words. This contribution facilitates the implementation of other applications related to the automatic processing of the Amazigh language.</span></span>
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Ma, Chao, Haiying Gao y Duo Wei. "A CP-ABE Scheme Supporting Arithmetic Span Programs". Security and Communication Networks 2020 (16 de marzo de 2020): 1–16. http://dx.doi.org/10.1155/2020/3265871.
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Attribute-based encryption achieves fine-grained access control, especially in a cloud computing environment. In a ciphertext-policy attribute-based encryption (CP-ABE) scheme, the ciphertexts are associated with the access policies, while the secret keys are determined by the attributes. In recent years, people have tried to find more effective access structures to improve the efficiency of encryption systems. This paper presents a ciphertext-policy attribute-based encryption scheme that supports arithmetic span programs. On the composite-order bilinear group, the security of the scheme is proven by experimental sequence based on the combination of composite-order bilinear entropy expansion lemma and subgroup decision (SD) assumption. And, it is an adaptively secure scheme with constant-size public parameters.
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Sandoval Moreno, Adriana. "Organización comunitaria y sustentabilidad del agua". Ambiente y Desarrollo 19, n.º 36 (15 de abril de 2015): 13. http://dx.doi.org/10.11144/javeriana.ayd19-36.cows.
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Mediante el método cualitativo se analiza cómo las organizaciones comunitarias para el riego y para el consumo humano del agua hacen frente a la problemática de la sustentabilidad de este recurso en la región Lerma-Chapala de Michoacán, México. Los resultados muestran, por un lado, que las organizaciones se basan en arreglos consuetudinarios, buscan la distribución equitativa del agua y tienen una función de control sobre esta en forma de autogestión, con recursos propios, capacidades, saberes y marcos institucionales comunitarios. Por otro lado, hay evidencias de desgaste y presión hacia estas formas de acción colectiva, debido a las dinámicas productivas del modelo económico imperante. Como conclusión se anotan los aportes de estas organizaciones para la sustentabilidad del agua en la región. </span></p></div></div></div>
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Chassot, Attico. "Haciendo educación en ciencias en los estudios de Pedagogía con la inclusión de saberes populares en el currículum". Educación Química 18, n.º 1 (22 de agosto de 2018): 12. http://dx.doi.org/10.22201/fq.18708404e.2007.1.65972.
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<span>Alentado por el lema «cuando muere un anciano es como si se quemara una biblioteca», el artículo propone una investigación que incluye acciones de alumnas y alumnos de Pedagogía como investigadores de saberes populares para llevarlos a la clase e, iluminados por los saberes académicos, convertirlos en saberes escolares. La propuesta se centra en desencadenar un diálogo entre generaciones con la exigencia de superar obstáculos como el presentismo o el cientifismo con el propósito de salvar conocimientos en peligro de extinción por el olvido o por la biopiratería. Además del objetivo central nuevos saberes escolares se apuntan como objetivos secundarios ciertas modificaciones en la relación entre los investigados y los investigadores.</span>
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Da Silva, Roberta Bernardo, Maria Edneia Gonçalves Quinto y Debora Frota Chagas. "4 PASSOS PARA ALÇAR VOOS: Tecendo juventude, educação, arte e cultura de paz". IAÇÁ: Artes da Cena 3, n.º 2 (26 de diciembre de 2020): 202. http://dx.doi.org/10.18468/iaca.2020v3n2.p202-214.
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<p align="center"><strong style="font-family: Calibri, serif;">RESUMO</strong></p><p align="left"> <span style="font-size: medium; font-family: Calibri, serif;">Esta pesquisa desenvolve diálogos e reflexões entre conteúdos obrigatórios da educação básica formal e os discursos apresentados nos corpos dos jovens da Escola de Polícia Militar do Ceará, General Edgar Facó. Com o objetivo de elucidar o conteúdo da convivência dos jovens, focaremos na disciplina comportamental com o seguinte lema: o que um corpo diz, dois corpos, muitos corpos? Metodologicamente, a investigação teve, de modo didático, quatro etapas: i): Introdução do Projeto; ii): Construção do Projeto; (iii): Duração do Projeto na Escola; (iv): Procedimentos metodológicos: percurso, descrição e análise. Assim, teceremos conhecimento empírico e conceitual para discutir o desenvolvimento do corpo educacional dos alunos junto aos conceitos de jogo e cultura de paz.</span></p><p align="left"><span style="font-family: Calibri, serif;">PALAVRAS-CHAVE: Juventude, educação, arte, cultura de paz</span></p>
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FICKENSCHER, JONATHAN. "SELF-INVERSES, LAGRANGIAN PERMUTATIONS AND MINIMAL INTERVAL EXCHANGE TRANSFORMATIONS WITH MANY ERGODIC MEASURES". Communications in Contemporary Mathematics 16, n.º 01 (21 de enero de 2014): 1350019. http://dx.doi.org/10.1142/s0219199713500193.
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Thanks to works by Kontsevich and Zorich followed by Boissy, we have a classification of all Rauzy Classes of any given genus. It follows from these works that Rauzy Classes are closed under the operation of inverting the permutation. In this paper, we shall prove the existence of self-inverse permutations in every Rauzy Class by giving an explicit construction of such an element satisfying the sufficient conditions. We will also show that self-inverse permutations are Lagrangian, meaning any suspension has its vertical cycles span a Lagrangian subspace in homology. This will simplify the proof of a lemma in a work by Forni. Veech proved a bound on the number of distinct ergodic probability measures for a given minimal interval exchange transformation. We verify that this bound is sharp by constructing examples in each Rauzy Class.
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Thijssen, Lucia G. A. "'Divcrsi ritratti dal naturale a cavallo' : een ruiterportret uit het atelier van Rubens geïdentificeerd als Ambrogio Spinola". Oud Holland - Quarterly for Dutch Art History 101, n.º 1 (1987): 50–63. http://dx.doi.org/10.1163/187501787x00033.
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AbstractThe closeness of a work from Rubens' studio in the English Royal Collection, known as Equestrian Portrait of a Knight of the Golden Fleece (Fig. I, Note 1), to two equestrian portraits painted by Van Dyck during his stay in Genoa, from 1621 to 1626 (Figs. 2, 3, Note 2) has led to the identification of the sitter. A number of other pictures from the circle of Rubens and Van Dyck show horses and/or riders in related poses and the dates on some of them reveal them to have been painted before Van Dyck's portraits. This applies to The Riding School by or after Rubens, which is generally dated 1610-12 (Fig. 4, Note 3), a Paradise Landscape by Jan Brueghel of 1613 (Note 4) and Sight dated 1617 by the same artist (Fig.5, Note 5), which features a horseman known as Archduke Albert. A number of undated paintings inspired by the same model include six supposed to be of Archduke Albert (Notes 6, 10), three by Casper de Crayer (Fig. 6, Note 13) and eguestrian portraits of Louis XIII (Note 14) and Ladislaw IV of Poland. Thus it seems likely that these followers of Rubens', Van Dyck included, based themselves on one and the same equestrian portrait by their teacher. Since Van Dyck almost certainly painted the two equestrian portraits in Genoa during his stay in that city, his model or a replica of it must also have been there between 1621 and 1626. In fact, probably at the request of his patrons (Note 17), he often used models by Rubens, who had worked in Genoa for a time in 1606 (Note 16). However, his two equestrian portraits are not based on the only Genoese one by Rubens now known, that of the Marchese Doria (Fig. 7, Note 18), which is very different and has a liveliness quite, unlike Van Dyck's quiet static compositions. The equestrian portrait in the English Royal Collection was bought by George I in 1723 as a Rubens. The sitter is clad in the Spanish costume of the early 17 th century while the towers in the background could be those of Antwerp (Note 36). The sitter has been identified as the Archduke Albert, but he actually bears no resemblance to other portraits of the Archduke, who was also much older than this at the time of Ruberas' stay in Genoa in 1606. The most likely candidate is Ambrogio Spinola (Note 32) , the statesman and general, of whom both Rubens and Van Dyck painted more than one portrait. Spinola was commander of the Spanish troups in the Southern Netherlands, a friend of Rubens and Knight of the Golden Fleece, and he also came from Genoa, where this portrait could have been painted during a visit he made to the city in 1606 (Notes 33, 34). Stylistically too the portrait seems to fit in with the series of portraits painted by Rubens in Genoa in that year. The physiognomy of the sitter is certainly close to that of the known portraits of Spinola (Figs. 8-1, Note 35), while the details of Spinola's life also support the identification. Spinola (1569-1630), who was Marquis of Sesto and Venafro, belonged to one of the group of closely related, families of bankers who held key positions in Genoa. He arrived in the Netherlands around 1602 at the head of a large and unusually well-trained body of troops. In 1603 he provided funds to prevent a mutiny among the Spanish troups and after his capture of Ostend in 1604 he was appointed second in command to Archduke Albert. He was made a Knight of the Golden Fleece on I March 1605 and in the same year he was put in charge of military finances. From 1606 until his departure for Spain in 1628 he was superintendent of the military treasury and' mayordomo mayor' to the Archdukes Albert and Isabella. After the death of Albert in 1621 he became principal adviser to Isabella and thus the most powerful man in the Spanish Netherlands. His amiable character brought him many friends, even among the ranks of the enemy, notably the Princes Maurice and Frederick Henry, with whom he had a great deal of contact during the Twelve Years Truce. It was probably one of them who bought the Portrait of Spinola by Van Miereveld (Fig. 8). After a disappointing mission to Spain in 1628, Spinola was relieved of his command of the Army of Flanders and put in charge of the Spanish troups in Lombardy. He died in his castle in Piedmont in 1630. During the years 1603-5 and later Spinola made several visits to Madrid, where he will undoubtedly have met the powerful Duke of Lerma and probably also seen the equestrian portrait that Rubens painted of him in 1603 (Fig. 12, Note 39). He must also have known of the portraits Rubens painted in Genoa in 1606, since at least three and probably five of them are of members of the Spinola family, while there survives a letter to Rubens from Paolo Agostino Spinola on the subject of portraits (Note 40). All this makes it likely that Spinola would have had his own Portrait painted too and that Rubens may well have painted his first portrait of the man who was to become his lifelong friend as early as 1606. Although Rubens was sometimes irritated by Spinola's lack of interest in his work (Note 41) , he admired him greatly (Note 42). He cultivated Spinola's friendship after his return to Antwerp in 1608 and will doubtless have introduced Van Dyck to him. Van Dyck later painted more than twenty pictures for the five Spinola palaces (Note 43) in Genoa and his work also became known in Madrid via Spinola and his son-in-law Don Diego Felipez Messia Guzman de Legañes, who owned many works by Van Dyck (Note 44). The presumed equestrian portrait of Spinola was much copied, as were other portraits of him by Rubens. Spinola was admired all over Europe and that may have been why other commanders and princes wanted to have themselves portrayed in the same way. The original or a replica may have hung in Spirtola's palace in Brussels, where the first to have seen it would have been Archduke Albert, which may explain the many equestrian portraits of him by Rubens' followeers which were based on it. Another possibility is that Rubens himself may have painted an equestrian portrait of the Archduke very similar to that of Spinola around 1610, but that this is no longer known. Caspar de Crayer of Brussels, a friend, though not a pupil of Rubens, was also influenced by the Spinola equestrian portrait. Furthermore, when he was invited to paint a set of equestrian portraits for the Huis ten Bosch, he sent the young Antwerp painter Thomas Willeboirts Bosschaert to The Hague in his place (Note 46) and it was in this way that Rubens' model came to the Northern Netherlands, where it was copied only once, by Isaac Isacsz. in his equestrian portrait of William the Silent (Note 47). The equestrian portrait of Sigmund III of Poland (Fig. 13), a cousin of Archduke Albert, could also have been painted in Van Dyck's studio in Genoa, which was probably visited by his son Prince Ladislaw in 1624 (Note 48). This picture too still owes much to Rubens' model which Van Dyck used again ten years later for his equestrian portraits of Charles I of England (Fig. 14, Note, 50) and Francisco de Moncada (Note 51).
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Opoku, Alex Akwasi y Godwin Osabutey. "Multipopulation Spin Models: A View from Large Deviations Theoretic Window". Journal of Mathematics 2018 (1 de noviembre de 2018): 1–13. http://dx.doi.org/10.1155/2018/9417547.
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This paper studies large deviations properties of vectors of empirical means and measures generated as follows. Consider a sequence X1,X2,…,Xn of independent and identically distributed random variables partitioned into d-subgroups with sizes n1,…,nd. Further, consider a d-dimensional vector mn whose coordinates are made up of the empirical means of the subgroups. We prove the following. (1) The sequence of vector of empirical means mn satisfies large deviations principle with rate n and rate function I, when the sequence X1,X2,…,Xn is Rl valued, with l≥1. (2) Similar large deviations results hold for the corresponding sequence of vector of empirical measures Ln if Xi’s, i=1,2,…,n, take on finitely many values. (3) The rate functions for the above large deviations principles are convex combinations of the corresponding rate functions arising from the large deviations principles of the coordinates of mn and Ln. The probability distributions used in the convex combinations are given by α=(α1,…,αd)=limn→∞1/n(n1,…,nd). These results are consequently used to derive variational formula for the thermodynamic limit for the pressure of multipopulation Curie-Weiss (I. Gallo and P. Contucci (2008), and I. Gallo (2009)) and mean-field Pott’s models, via a version of Varadhan’s integral lemma for an equicontinuous family of functions. These multipopulation models serve as a paradigm for decision-making context where social interaction and other socioeconomic attributes of individuals play a crucial role.
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Parera, Cecilia. "Un “corazón” en el desierto. Indagaciones en torno a la propuesta urbana de la Villa el Chocón en la Patagonia argentina (1968/1972)". Anales de Investigación en Arquitectura 9, n.º 1 (3 de julio de 2019): 25. http://dx.doi.org/10.18861/ania.2019.9.2899.
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<p class="p1"><span class="s1">En los años cincuenta y sesenta del siglo XX se difundió una crítica disciplinar sobre la ciudad existente, rechazando los postulados funcionalistas aplicados en la entre-guerra, en beneficio de lecturas atentas a la percepción fenomenológica del espacio, a la mixtura de usos y a la escala humana. El artículo pretende indagar en torno a este cambio de paradigma disciplinar, adoptando a la Villa el Chocón en la Patagonia argentina, y particularmente a la propuesta para su centro cívico, como principal caso de estudio, siendo que este pequeño poblado pone en evidencia un nuevo abordaje proyectual. En particular, la hipótesis del trabajo plantea una proximidad conceptual de los autores de la mencionada obra con los postulados que fundamentaron el alejamiento del llamado Movimiento Moderno, así como una adhesión al lema “el corazón de la ciudad”, cuestiones debatidas en sede europea desde principios de la década de 1950. En atención a los objetivos planteados, el análisis histórico-crítico del caso seleccionado ha permitido identificar estas afinidades, diferenciadas tanto del racionalismo como estrategia predominante hasta el estallido de la Segunda Guerra Mundial, como el posterior abordaje sistémico e indeterminado que caracterizaría a gran parte de la producción arquitectónica de los años 1970 en Argentina.</span></p>
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ABELLÁN LÓPEZ, María Ángeles y Bernabé ALDEGUER CERDÁ. "Los Órganos de control externo (OCEX): una aproximación desde la perspectiva de las Relaciones Intergubernamentales". RVAP 109-I, n.º 109-I (29 de diciembre de 2017): 311–38. http://dx.doi.org/10.47623/ivap-rvap.109.2017.1.09.
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LABURPENA: Konfiantza-ezak eta eragile politikoen arteko lankidetza-urritasunak ezaugarritu izan dituzte Espainiako gobernuen arteko harremanak. Gobernuen arteko eztabaida-testuinguru horretan, jarduera onen kasu arrakastatsu bat aurkezten du artikulu honek, non Kanpo Kontrolerako Organo Autonomikoak (OCEX) izan ziren protagonista. Autonomia-erkidego batzuek beren Kanpo Kontrolerako Organo Autonomikoak sortu zituzten, eta foroak eta lankidetza-topaketak instituzionalizatu zituzten, emaitza bikainekin, Fiskalizazioko Goi Mailako Erakundeen Nazioarteko Erakundearen (INTOSAI) «Experientia mutua omnibus prodest» leloaren pean. RESUMEN: Las relaciones intergubernamentales en España se han caracterizado por la desconfianza y un déficit de colaboración entre los actores políticos. En este contexto de controversia intergubernamental, este artículo presenta un caso de éxito de buenas prácticas protagonizado por los Órganos de Control Externo Autonómicos, conocidos como los OCEX. Algunas Comunidades Autónomas crearon sus propios OCEX y han institucionalizado foros y encuentros de colaboración y cooperación, con excelentes resultados, bajo el lema de la Organización Internacional de Instituciones Superiores de Fiscalización (INTOSAI), «Experientia mutua omnibus prodest». ABSTRACT: Intergovernmental relations in Spain have been characterized by mistrust and a lack of collaboration among political actors. In this context of intergovernmental controversy, this article presents a case of success related to several good practices fostered by the autonomic bodies of external control, known as OCEX. Some Autonomous Communities created their own OCEX institutionalizing forums and meetings of collaboration and cooperation, with excellent results, under the motto of the International Organization of Supreme Audit Institutions (INTOSAI), «Experientia mutua omnibus prodest».
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Boscolo, Manuela, Jean-Pierre Delahaye y Mark Palmer. "The Future Prospects of Muon Colliders and Neutrino Factories". Reviews of Accelerator Science and Technology 10, n.º 01 (agosto de 2019): 189–214. http://dx.doi.org/10.1142/s179362681930010x.
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The potential of muon beams for high energy physics applications is described along with the challenges of producing high quality muon beams. Two proposed approaches for delivering high intensity muon beams, a proton driver source and a positron driver source, are described and compared. The proton driver concepts are based on the studies from the Muon Accelerator Program (MAP). The MAP effort focused on a path to deliver muon-based facilities, ranging from neutrino factories to muon colliders, that could span research needs at both the intensity and energy frontiers. The Low EMittance Muon Accelerator (LEMMA) concept, which uses a positron-driven source, provides an attractive path to very high energy lepton colliders with improved particle backgrounds. The recent study of a 14-TeV muon collider in the LHC tunnel, which could leverage the existing CERN injectors and infrastructure and provide physics reach comparable to the 100[Formula: see text]TeV FCC-hh, at lower cost and with cleaner physics conditions, is also discussed. The present status of the design and R&D efforts towards each of these sources is described. A summary of important R&D required to establish a facility path for each concept is also presented.
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Gudkova, P. D., M. V. Olonova, R. S. Romanets y I. Yu Boyko. "Популяционная изменчивость Stipa capillata L. на территории Алтайского края". Ukrainian Journal of Ecology 7, n.º 4 (22 de diciembre de 2017): 277–89. http://dx.doi.org/10.15421/2017_117.
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<p>The genus Stipa in the Altai territory is represented by 12 species (Lomonosova, 2003, Silanteva, 2013, Gudkova et al., 2015). Stipacapillata L., which belongs to the Leiostipa Dumor. section, is one of the most widespread species of this genus. Besides S. capillata, two more species of this section – S. praecapillata Alech. and S. Baicalensis Roshev. occur on the territory of the region. However, they both have a very limited distribution: the first is represented by single finds in Klyuchevsky, Kuryinsky, Pospelikhinsky and Rubtsovsky districts of Altay, and the latter one occurs only in Charyshsky district. Thus, in the territory of the region there is a unique opportunity to study the population variability of S. capillata, as in other regions it often grows together with closely related species and hybridizes with them (in the west with S. sareptana A. Beck., and S. praecapillata Alech., and in the south and east - with S. grandis P. Smirn, S. krylovii Roshev and S. baicalensis.<br />The problem of the volume and boundaries of S. capillata L. is caused by its wide distribution from Spain to Yakutia and high polymorphism. Many authors accepted the different limits of variability in the characteristics of S. capillata, which makes it difficult to define this taxon, for instance, in almost all the floristic revisions the authors suggest, that the node of generative shoot is hidden by the leaf sheathes because of the leaf sheath is longer than the internode, and only N.N. Tsvelev (Tzvelev, 1976) and H. Freitag (Freitag, 1985) admit that a node within this species can be exposed. The purpose of our study was to research the population variability of S. capillata on the territory of the Altai in order to specify the limits of its features variation. 242 individuals of S. capillata belonging to 11 populations were involved in the analysis. The paper presents the result of statistical analysis by 26 quantitative and 2 qualitative features. A description of the lemma ultrastructure is also given. On the basis of the analysis, a refined morphological description of the species is given and the limits of variability of characteristics are indicated. It has also been established that some individuals with trichomes up to 0.15 mm on the tip of lemma, as well as individuals with closed nodes can be found within S. capillata species. It rejects the morphological pattern, accepted for S. capillata earlier. Despite the significant broadening of the boundaries of the variability of the signs, morphological differentiation was not revealed. All objects included in the analysis form a single cluster and belong to one general population. Also, the article provides information on the ecologo-cenotic association and distribution of this species based on the revision of herbarium collections stored in AA, BM, E, GAT, K, KAS, KRA, KUZ, LE, M, MW, MHA, TK, NS, NSK, UPS.</p>
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Gallez, Caroline y Benjamin Motte-Baumvol. "Inclusive Mobility or Inclusive Accessibility? A European Perspective". Cuadernos Europeos de Deusto, n.º 56 (30 de abril de 2017): 79. http://dx.doi.org/10.18543/ced-56-2017pp79-104.
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<p>“La movilidad inclusiva” es parte de las prioridades políticas definidas por numerosos países europeos para referirse a la dimensión social del transporte o las políticas de movilidad cotidiana. De forma general, la inclusión se refiere a la cohesión social, que ha sido uno de los objetivos declarados de la Unión Europea desde el inicio de los años 2000. Como mecanismo para facilitar el acceso a las oportunidades (empleo, comercio, servicios, etc.), la movilidad individual es actualmente considerada un prerrequisito necesario para la participación de las personas en las actividades sociales. En contraste, la inmovilidad o “ausencia de movilidad” sería un factor de exclusión social. Sin embargo, en razón de la ambigüedad de la movilidad, que puede considerarse un recurso esencial (facilitador de acceso a oportunidades en el contexto de una dispersión mayor de las actividades) o un coste (monetario, medioambiental, físico); un derecho básico o un precepto político para movilidad (los objetivos políticos de la movilidad pueden esconder algunas contradicciones). Este artículo se concentra en diferentes problemáticas en relación a la movilidad inclusiva en Europa. Para empezar, presentamos cómo el lema de la “movilidad inclusiva” es utilizado en los documentos oficiales de la Comisión Europea. Posteriormente, se analiza cómo la cuestión de la movilidad inclusiva ha emergido en Francia y en el Reino Unido, en relación a la generalización del problema de la exclusión social. Se completará esta visión de políticas públicas ofreciendo un panorama de las desigualdades sociales en relación a la movilidad cotidiana en diferentes países europeos. Finalmente, se argumenta la necesidad de evolucionar desde una prioridad política de la movilidad inclusiva hacia la accesibilidad inclusiva, considerando que las políticas de movilidad, como elemento favorecedor de la dispersión de las actividades, pueden incrementar la presión sobre los grupos sociales desfavorecidos para ser móviles.</p><p><strong>Recibido</strong>: 09 enero 2017<br /><strong>Aceptado</strong>: 06 marzo 2017<br /><strong>Publicación en línea</strong><span>: 02 mayo 2017</span></p>
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Ahmad, Nabil M., Peter M. Martin y John M. Vella. "Floral morphogenesis and proliferation in Poa labillardieri (Poaceae)". Australian Journal of Botany 57, n.º 7 (2009): 602. http://dx.doi.org/10.1071/bt08071.
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Inflorescence and spikelet development in Poa labillardieri Steud. were investigated by scanning electron microscopy. Thirteen developmental stages were described in detail, starting with the vegetative shoot apex which was shown to be of the short type (stage zero), followed by a conversion from vegetative to floral meristem at Stage 1 and ending at Stage 12, with a mature panicle consisting of a variable number of florets at anthesis within each spikelet. The occurrence of short-type vegetative apices in this perennial grass adds further support to the view that there is no correlation between life span and the apex type. The branches of the P. labillardieri panicle are formed in acropetal succession; however, it is the upper branches that first bear rudiments of the spikelets, starting at the tip of the branches. In contrast differentiation of florets within each spikelet occurs in acropetal succession, so that the basal floret is farthest advanced and each successively upper floret less advanced. P. labillardieri occasionally produces inflorescences containing spikelets in which some or all of the florets are replaced by a plantlet that is structurally similar to a vegetative tiller. Proliferous development ranged from a situation where all florets were converted to vegetative propagules that can be detached and rooted readily in soil, to cases where proliferation extended only as far as an enlargement of the lemma, with either functional or non-functional sexual organs in its axil. Under greenhouse conditions, there was a shift from occasional cases of partially proliferating spikelets that occur in the wild to complete vigorous proliferation stimulated by unknown factor(s). Departure from the normal sexual pattern took place from early Stage 5 (initiation of spikelet primordial) to late Stage 6 (differentiation of florets).
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Pulito-Cueto, V., S. Remuzgo Martinez, F. Genre, B. Atienza-Mateo, V. M. Mora-Cuesta, D. Iturbe-Fernández, L. Lera-Gómez et al. "AB0094 INCREASE OF ENDOTHELIAL PROGENITOR CELLS IN SYSTEMIC SCLEROSIS-ASSOCIATED INTERSTITIAL LUNG DISEASE". Annals of the Rheumatic Diseases 80, Suppl 1 (19 de mayo de 2021): 1076.1–1076. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2350.
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Background:Endothelial progenitor cells (EPC), involved in vasculogenesis and endothelial tissue repair, have been described as relevant players in vascular and connective tissue diseases [1-2]. In this regard, a previous study of our group disclosed that the degree of EPC frequency may help to identify the presence of interstitial lung disease (ILD) in rheumatoid arthritis patients [3]. Given that ILD is the main cause of mortality in patients with systemic sclerosis (SSc) [1, 4-6], the understanding of the role of EPC in the mechanism of SSc-ILD+ vasculopathy is crucial.Objectives:To assess the potential role of EPC on vascular dysfunction associated with the presence of ILD in patients with SSc.Methods:Peripheral venous blood was collected from a total of 39 patients with SSc, 20 with ILD (SSc-ILD+) and 19 without ILD (SSc-ILD-). All subjects were recruited from the Rheumatology and Pneumology departments of Hospital Universitario Marqués de Valdecilla, Santander, Spain. Quantification of EPC was analyzed by flow cytometry. EPC were considered as CD34+, CD45Low, CD309+ and CD133+.Results:Statistically significant differences in EPC frequency between patients with SSc-ILD+ and patients with SSc-ILD- were disclosed. Specifically, an increase of EPC frequency was observed in SSc-ILD+ patients when compared to patients with SSc-ILD- (mean ± standard deviation: 0.033 ± 0.012 versus 0.021 ± 0.017, respectively, p=0.012).Conclusion:Our results suggest a potential role of EPC on vascular damage associated with the manifestation of ILD in patients with SSc.References:[1]Eur J Rheumatol 2020;7(Suppl 3):S139-S146.[2]Arthritis Rheum 2009;60(11):3168-79.[3]J Clin Med 2020;9(12):4098.[4]Ann Rheum Dis 2007;66(7):940-4.[5]Rheumatology (Oxford) 2010;49(12):2375-80.[6]Eur Respir Rev 2015;24(135):102-14.Acknowledgements:Personal funds, VP-C: PREVAL18/01 (IDIVAL); SR-M: RD16/0012/0009 (ISCIII-ERDF); LL-G: INNVAL20/06 (IDIVAL); RP-F: START PROJECT (FOREUM); RL-M: Miguel Servet type I CP16/00033 (ISCIII-ESF).Disclosure of Interests:Verónica Pulito-Cueto: None declared, Sara Remuzgo Martinez: None declared, Fernanda Genre: None declared, Belén Atienza-Mateo: None declared, Victor Manuel Mora-Cuesta: None declared, David Iturbe-Fernández: None declared, Leticia Lera-Gómez: None declared, Raquel Pérez-Fernández: None declared, Diana Prieto-Peña: None declared, Virginia Portilla: None declared, Ricardo Blanco Speakers bureau: Abbvie, Pfizer, Roche, Bristol-Myers, Janssen and MSD, Consultant of: Abbvie, Pfizer, Roche, Bristol-Myers, Janssen and MSD, Grant/research support from: Abbvie, MSD and Roche, Alfonso Corrales: None declared, Jose Manuel Cifrián-Martínez: None declared, Raquel López-Mejías: None declared, Miguel A González-Gay Speakers bureau: Pfizer, Abbvie, MSD, Grant/research support from: Pfizer, Abbvie, MSD
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Remuzgo Martinez, S., F. Genre, V. Pulito-Cueto, D. Prieto-Peña, B. Atienza-Mateo, B. Sevilla, J. Llorca et al. "AB0012 ROLE OF IRF5 GENE ON THE PATHOGENESIS OF IMMUNOGLOBULIN-A VASCULITIS". Annals of the Rheumatic Diseases 79, Suppl 1 (junio de 2020): 1309.1–1310. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1023.
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Background:Interferon signaling pathway plays a relevant role in autoimmunity. Genetic variants in theinterferon regulatory factor (IRF) 5gene, that encodes the major regulator of the type I interferon induction [1], have been related to the development of several inflammatory diseases [2].Objectives:To determine the influence ofIRF5on Immunoglobulin-A vasculitis (IgAV), an inflammatory vascular disease.Methods:ThreeIRF5polymorphisms (rs2004640, rs2070197 and rs10954213) representative of 3 different haplotype blocks were genotyped in 372 Caucasian patients with IgAV and 876 sex and ethnically matched healthy controls.Results:No statistically significant differences between patients with IgAV and controls were observed when eachIRF5polymorphism was analyzed independently. Similarly, no statistically significant differences between patients with IgAV and controls were found whenIRF5polymorphisms were evaluated combined conforming haplotypes. Additionally, there were no statistically significant differences in genotype, allele and haplotype frequencies ofIRF5when patients with IgAV were stratified according to the age at disease onset or to the presence/absence of gastrointestinal or renal manifestations.Conclusion:Our results do not support an influence ofIRF5on the pathogenesis of IgAV.References:[1]Nat Immunol 2011; 12: 231-8;[2]Arthritis Res Ther 2014; 16: R146.Acknowledgments:This study was supported by European Union FEDER funds and “Fondo de Investigaciones Sanitarias” (grant PI18/00042) from ‘Instituto de Salud Carlos III’ (ISCIII, Health Ministry, Spain). RL-M is a recipient of a Miguel Servet type I programme fellowship from the ISCIII, co-funded by the European Social Fund (ESF, `Investing in your future´) (grant CP16/00033). SR-M is supported by funds of the RETICS Program (RD16/0012/0009) (ISCIII, co-funded by the European Regional Development Fund (ERDF)). VP-C is supported by a pre-doctoral grant from IDIVAL (PREVAL 18/01). LL-G is supported by funds of PI18/00042 (ISCIII, co-funded by ERDF).Disclosure of Interests:Sara Remuzgo Martinez: None declared, Fernanda Genre: None declared, Verónica Pulito-Cueto: None declared, D. Prieto-Peña: None declared, Belén Atienza-Mateo: None declared, Belén Sevilla: None declared, Javier Llorca: None declared, Norberto Ortego: None declared, Leticia Lera-Gómez: None declared, Maite Leonardo: None declared, Ana Peñalba: None declared, María Jesús Cabero: None declared, Luis Martín-Penagos: None declared, Jose Alberto Miranda-Filloy: None declared, Antonio Navas Parejo: None declared, Javier Sanchez Perez: None declared, Maximiliano Aragües: None declared, Esteban Rubio: None declared, MANUEL LEON LUQUE: None declared, Juan María Blanco-Madrigal: None declared, E. Galindez: None declared, Javier Martin Ibanez: None declared, Santos Castañeda: None declared, Ricardo Blanco Grant/research support from: Abbvie, MSD and Roche, Consultant of: Abbvie, Pfizer, Roche, Bristol-Myers, Janssen and MSD, Speakers bureau: Abbvie, Pfizer, Roche, Bristol-Myers, Janssen, Lilly and MSD, Miguel A González-Gay Grant/research support from: Pfizer, Abbvie, MSD, Speakers bureau: Pfizer, Abbvie, MSD, Raquel López-Mejías: None declared
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Genre, F., S. Remuzgo Martinez, V. Pulito-Cueto, D. Prieto-Peña, B. Atienza-Mateo, B. Sevilla, J. Llorca et al. "AB0011 INFLUENCE OF IL17A GENE ON THE PATHOGENESIS OF IMMUNOGLOBULIN-A VASCULITIS". Annals of the Rheumatic Diseases 79, Suppl 1 (junio de 2020): 1309.2–1309. http://dx.doi.org/10.1136/annrheumdis-2020-eular.641.
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Background:Cytokines signaling pathway genes represent a key component of the genetic network implicated in the pathogenesis of Immunoglobulin-A vasculitis (IgAV) [1], an inflammatory vascular pathology.Interleukin (IL)17Ais a genetic risklocusfor autoimmune diseases, such as giant cell arteritis [2] and spondyloarthritis [3].Objectives:To determine the potential influence ofIL17Aon IgAV.Methods:FiveIL17Atag polymorphisms (rs4711998, rs8193036, rs3819024, rs2275913 and rs7747909) were genotyped in 360 Caucasian patients with IgAV and 1,003 sex and ethnically matched healthy controls.Results:No statistically significant differences between patients with IgAV and healthy controls were observed when eachIL17Agenetic variant was analyzed independently. Similarly, no statistically significant differences between patients with IgAV and healthy controls were found when the fiveIL17Apolymorphisms were evaluated combined conforming haplotypes. In addition, there were no statistically significant differences in genotype, allele and haplotype frequencies ofIL17Awhen patients with IgAV were stratified according to the age at disease onset or to the presence/absence of gastrointestinal or renal manifestations.Conclusion:Our results do not support an influence ofIL17Aon the pathogenesis of IgAV.References:[1]Autoimmun Rev 2018; 17: 301-15[2]Ann Rheum Dis 2014; 73: 1742-5[3]Mediators Inflamm 2018; 2018: 1395823.Acknowledgments:This study was supported by European Union FEDER funds and “Fondo de Investigaciones Sanitarias” (grant PI18/00042) from ‘Instituto de Salud Carlos III’ (ISCIII, Health Ministry, Spain). RL-M is a recipient of a Miguel Servet type I programme fellowship from the ISCIII, co-funded by the European Social Fund (ESF, `Investing in your future´) (grant CP16/00033). SR-M is supported by funds of the RETICS Program (RD16/0012/0009) (ISCIII, co-funded by the European Regional Development Fund (ERDF)). VP-C is supported by a pre-doctoral grant from IDIVAL (PREVAL 18/01). LL-G is supported by funds of PI18/00042 (ISCIII, co-funded by ERDF).Disclosure of Interests:Fernanda Genre: None declared, Sara Remuzgo Martinez: None declared, Verónica Pulito-Cueto: None declared, D. Prieto-Peña: None declared, Belén Atienza-Mateo: None declared, Belén Sevilla: None declared, Javier Llorca: None declared, Norberto Ortego: None declared, Leticia Lera-Gómez: None declared, Maite Leonardo: None declared, Ana Peñalba: None declared, María Jesús Cabero: None declared, Luis Martín-Penagos: None declared, Jose Alberto Miranda-Filloy: None declared, Antonio Navas Parejo: None declared, Diego de Argila: None declared, Maximiliano Aragües: None declared, Esteban Rubio-Romero: None declared, MANUEL LEON LUQUE: None declared, Juan María Blanco-Madrigal: None declared, E. Galindez: None declared, Javier Martin Ibanez: None declared, Santos Castañeda: None declared, Ricardo Blanco Grant/research support from: Abbvie, MSD and Roche, Consultant of: Abbvie, Pfizer, Roche, Bristol-Myers, Janssen and MSD, Speakers bureau: Abbvie, Pfizer, Roche, Bristol-Myers, Janssen, Lilly and MSD, Miguel A González-Gay Grant/research support from: Pfizer, Abbvie, MSD, Speakers bureau: Pfizer, Abbvie, MSD, Raquel López-Mejías: None declared
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Pulito-Cueto, V., S. Remuzgo Martinez, F. Genre, B. Atienza-Mateo, V. M. Mora-Cuesta, D. Iturbe-Fernández, L. Lera-Gómez et al. "AB0026 DECREASE OF ANGIOGENIC T CELLS IN CONNECTIVE TISSUE DISEASE-ASSOCIATED INTERSTITIAL LUNG DISEASE". Annals of the Rheumatic Diseases 80, Suppl 1 (19 de mayo de 2021): 1046.3–1047. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2676.
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Background:Interstitial lung disease (ILD) is one of the most significant complications of connective tissue diseases (CTD), leading to an increase of the morbidity and mortality in patients with CTD [1]. A specific T cell subset termed angiogenic T cells (TAng), that promote endothelial repair and revascularization, have been involved in the pathogenesis of CTD [2-4]. However, to the best of our knowledge, no information regarding the role of TAng in CTD-ILD+ is available.Objectives:To study, for the first time, the potential role of TAng related to vascular damage in CTD-ILD+.Methods:Peripheral venous blood was collected from 40 patients with CTD-ILD+ and three comparative groups: 44 CTD-ILD- patients, 21 idiopathic pulmonary fibrosis (IPF) patients and 20 healthy controls (HC). All subjects were recruited from the Rheumatology and Pneumology departments of Hospital Universitario Marqués de Valdecilla, Santander, Spain. Quantification of TAng was performed by flow cytometry. TAng were considered as triple-positive for CD3, CD31 and CXCR4.Results:Patients with CTD-ILD+ exhibited a significantly lower TAng frequency than CTD-ILD- patients (p<0.001). Similar results were obtained when patients with CTD-ILD+ were compared with HC (p=0.004) although no difference was observed between CTD-ILD+ and IPF. In addition, a significant increase of TAng frequency was shown in patients with CTD-ILD- in relation to IPF patients (p<0.001), while no difference was observed between CTD-ILD- and HC.Conclusion:Our results reveal a decrease of TAng frequency related to vascular damage in CTD-ILD+. Furthermore, we disclose that the presence of ILD is associated with lower TAng frequency.References:[1]Expert Rev Clin Immunol 2018;14(1):69-82.[2]Circulation 2007;116(15):1671-82.[3]Ann Rheum Dis 2015 74(5):921-7.[4]PLoS One 2017;12(8):e0183102.Acknowledgements:Personal funds, VP-C: PREVAL18/01 (IDIVAL); SR-M: RD16/0012/0009 (ISCIII-ERDF); LL-G: INNVAL20/06 (IDIVAL); RP-F: START PROJECT (FOREUM); RL-M: Miguel Servet type I CP16/00033 (ISCIII-ESF).Disclosure of Interests:Verónica Pulito-Cueto: None declared, Sara Remuzgo Martinez: None declared, Fernanda Genre: None declared, Belén Atienza-Mateo: None declared, Victor Manuel Mora-Cuesta: None declared, David Iturbe-Fernández: None declared, Leticia Lera-Gómez: None declared, Raquel Pérez-Fernández: None declared, Pilar Alonso Lecue: None declared, Javier Rodriguez Carrio: None declared, Diana Prieto-Peña: None declared, Virginia Portilla: None declared, Ricardo Blanco Speakers bureau: Abbvie, Pfizer, Roche, Bristol-Myers, Janssen and MSD, Consultant of: Abbvie, Pfizer, Roche, Bristol-Myers, Janssen and MSD, Grant/research support from: Abbvie, MSD and Roche, Alfonso Corrales: None declared, Jose Manuel Cifrián-Martínez: None declared, Raquel López-Mejías: None declared, Miguel A González-Gay Speakers bureau: Pfizer, Abbvie, MSD, Grant/research support from: Pfizer, Abbvie, MSD
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Pulito-Cueto, V., S. Remuzgo-Martínez, F. Genre, V. M. Mora-Cuesta, D. Iturbe Fernández, S. Fernández-Rozas, L. Lera-Gómez et al. "SAT0014 ENDOTHELIAL PROGENITOR CELLS: ROLE IN ENDOTHELIAL DAMAGE OF INTERSTITIAL LUNG DISEASE ASSOCIATED TO RHEUMATOID ARTHRITIS". Annals of the Rheumatic Diseases 79, Suppl 1 (junio de 2020): 937.1–937. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3228.
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Background:Interstitial lung disease (ILD) is one of the most significant comorbidities of rheumatoid arthritis (RA), increasing the mortality in these patients [1,2]. Although the pathogenesis of ILD associated to RA (RA-ILD+) remains poorly defined [1], it is known that vascular tissue plays a crucial role in lung physiology [3]. In this context, a population of cells termed endothelial progenitor cells (EPC) are involved in vasculogenesis and endothelial tissue repair [4]. Previous reports suggest the implication of EPC in different conditions such as RA and idiopathic pulmonary fibrosis (IPF), the most common and destructive ILD [5,6]. Nevertheless, little is known about their specific role in RA-ILD+.Objectives:The purpose of this study was to shed light on the potential role of EPC in endothelial damage in RA-ILD+.Methods:Peripheral venous blood was collected from a total of 68 individuals (18 with RA-ILD+, 17 with RA-ILD-, 19 with IPF and 14 healthy controls). All subjects were recruited from the Rheumatology and Pneumology departments of Hospital Universitario Marqués de Valdecilla, Santander, Spain. Quantification of EPC was analyzed by the expression of surface antigens by flow cytometry. The combination of antibodies against the stem cell marker CD34, the immature progenitor marker CD133, the endothelial marker VEGF receptor 2 (CD309) and the common leukocyte antigen CD45 was used. EPC were considered as CD34+, CD45Low, CD309+and CD133+. All statistical analyses were performed using Prism software 5 (GraphPad).Results:EPC frequency was significantly increased in patients with RA-ILD+, RA-ILD-and IPF compared to controls (p=0.001, p=0.002, p< 0.0001, respectively). Nevertheless, patients with RA, both RA-ILD+and RA-ILD-, showed a lower frequency of EPC than those with IPF (p= 0.048, p= 0.006, respectively).Conclusion:Our results provide evidence for a potential role of EPC as a reparative compensatory mechanism related to endothelial damage in RA-ILD+, RA-ILD-and IPF patients. Interestingly, EPC frequency may help to establish a differential diagnostic between patients with IPF and those who have an underlying autoimmune disease (RA-ILD+).References:[1] J Clin Med 2019; 8: 2038;[2] Arthritis Rheumatol 2015; 67: 28-38;[3] Nat Protoc 2015; 10: 1697-1708;[4] Science 1997; 275: 964-966;[5] Rheumatology (Oxford) 2012; 51: 1775-1784;[6] Angiogenesis 2013; 16: 147-157.Acknowledgments:Personal funds, VP-C: PREVAL18/01 (IDIVAL); SR-M: RD16/0012/0009 (ISCIII-ERDF); LL-G: PI18/00042 (ISCIII-ERDF); RL-M: Miguel Servet type I CP16/00033 (ISCIII-ESF).Disclosure of Interests:Verónica Pulito-Cueto: None declared, Sara Remuzgo-Martínez: None declared, Fernanda Genre: None declared, Victor Manuel Mora-Cuesta: None declared, David Iturbe Fernández: None declared, Sonia Fernández-Rozas: None declared, Leticia Lera-Gómez: None declared, Pilar Alonso Lecue: None declared, Javier Rodriguez Carrio: None declared, Belén Atienza-Mateo: None declared, Virginia Portilla: None declared, David Merino: None declared, Ricardo Blanco Grant/research support from: AbbVie, MSD, Roche, Consultant of: Abbvie, Eli Lilly, Pfizer, Roche, Bristol-Myers, Janssen, UCB Pharma and MSD, Speakers bureau: Abbvie, Eli Lilly, Pfizer, Roche, Bristol-Myers, Janssen, UCB Pharma. MSD, Alfonso Corrales Speakers bureau: Abbvie, Jose Manuel Cifrián-Martínez: None declared, Raquel López-Mejías: None declared, Miguel A González-Gay Grant/research support from: Pfizer, Abbvie, MSD, Speakers bureau: Pfizer, Abbvie, MSD
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Prieto-Peña, D., F. Genre, S. Remuzgo Martinez, V. Pulito-Cueto, B. Atienza-Mateo, B. Sevilla, J. Llorca et al. "AB0096 IGA VASCULITIS AND IGA NEPHROPATHY SHARE A SIMILAR IL17A ASSOCIATION PATTERN". Annals of the Rheumatic Diseases 80, Suppl 1 (19 de mayo de 2021): 1076.3–1077. http://dx.doi.org/10.1136/annrheumdis-2021-eular.766.
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Background:IgA vasculitis (IgAV) and IgA nephropathy (IgAN) are inflammatory conditions that share pathogenic and molecular mechanisms [1] and may represent different outcomes of a continuous spectrum of disease [2]. Interleukin (IL)17A has been identified as a common genetic risk locus for several immune-mediated diseases [3, 4].Objectives:To determine whether IgAV and IgAN exhibit a different IL17A association pattern.Methods:Five IL17A tag polymorphisms (rs4711998, rs8193036, rs3819024, rs2275913 and rs7747909) were genotyped in 388 Caucasian patients with IgAV, 99 patients with IgAN and 1,003 sex and ethnically matched healthy controls.Results:No statistically significant differences between patients with IgAV and healthy controls and between patients with IgAN and healthy controls were observed when each IL17A genetic variant was analyzed independently (Table 1). Similarly, IgAV patients exhibited similar genotype and allele IL17A frequencies than those with IgAN (Table 1). Moreover, no genotype or allele differences between IgAV patients who developed nephritis and patients with IgAN were detected. Furthermore, haplotype frequencies were similar in patients with IgAV, IgAV and nephritis and those with IgAN.Table 1.Genotype and allele frequencies of IL17A gene in patients with IgA vasculitis, patients with IgA nephropathy and healthy controls.PolymorphismChangeData set1/11/22/212rs4711998G/AIgAV53.4 (207)38.9 (151)7.7 (30)72.8 (565)27.2 (211)IgAN49.0 (48)42.9 (42)8.2 (8)70.4 (138)29.6 (58)Controls52.7 (529)41.2 (413)6.1 (61)73.3 (1471)26.7 (535)rs8193036T/CIgAV57.0 (221)38.4 (149)4.6 (18)76.2 (591)23.8 (185)IgAN64.3 (63)31.6 (31)4.1 (4)80.1 (157)19.9 (39)Controls60.3 (605)35.2 (353)4.5 (45)77.9 (1563)22.1 (443)rs3819024A/GIgAV44.1 (171)43.3 (168)12.6 (49)65.7 (510)34.3 (266)IgAN39.4 (39)54.5 (54)6.1 (6)66.7 (132)33.3 (66)Controls45.6 (457)44.6 (447)9.9 (99)67.8 (1361)32.2 (645)rs2275913G/AIgAV44.6 (172)43.3 (167)12.2 (47)66.2 (511)33.8 (261)IgAN39.8 (39)53.1 (52)7.1 (7)66.3 (130)33.7 (66)Controls44.8 (449)44.2 (443)11.1 (111)66.8 (1341)33.2 (665)rs7747909G/AIgAV53.9 (209)39.4 (153)6.7 (26)73.6 (571)26.4 (205)IgAN41.1 (39)54.7 (52)4.2 (4)68.4 (130)31.6 (60)Controls53.0 (532)39.4 (395)7.6 (76)72.7 (1459)27.3 (547)Conclusion:Our results revealed that IgAV and IgAN share a similar IL17A association pattern.References:[1]N Engl J Med 2013;368:2402-14.[2]Am J Kidney Dis 1988;12:373-7.[3]Ann Rheum Dis 2014;73:1742-5.[4]Mediators Inflamm 2018;2018:1395823.Acknowledgements:This study was supported by European Union FEDER funds and “Fondo de Investigaciones Sanitarias” (grant PI18/00042) from ‘Instituto de Salud Carlos III’ (ISCIII, Health Ministry, Spain). DP-P is a recipient of a Río Hortega programme fellowship from the ISCIII, co-funded by the European Social Fund (ESF, `Investing in your future´) [grant number CM20/00006]; SR-M is supported by funds of the RETICS Program co-funded by the European Regional Development Fund (ERDF) [grant number RD16/0012/0009]; VP-C is supported by a pre-doctoral grant from IDIVAL [grant number PREVAL 18/01]; BA-M is a recipient of a `López Albo´ Post-Residency Programme funded by Servicio Cántabro de Salud; LL-G is supported by funds of IDIVAL [grant number INNVAL20/06]; RL-M is a recipient of a Miguel Servet type I programme fellowship from the ISCIII, co-funded by the European Social Fund (ESF, `Investing in your future´) [grant number CP16/00033].Disclosure of Interests:Diana Prieto-Peña: None declared, Fernanda Genre: None declared, Sara Remuzgo Martinez: None declared, Verónica Pulito-Cueto: None declared, Belén Atienza-Mateo: None declared, Belén Sevilla: None declared, Javier Llorca: None declared, Norberto Ortego: None declared, Leticia Lera-Gómez: None declared, Maite Leonardo: None declared, Ana Peñalba: None declared, Luis Martín-Penagos: None declared, Jose Alberto Miranda-Filloy: None declared, J. Narváez: None declared, LUIS CAMINAL MONTERO: None declared, PAZ COLLADO: None declared, Antonio Fernandez-Nebro: None declared, Gisela Díaz-Cordoves: None declared, Secundino Cigarrán: None declared, Jesús Calviño: None declared, Carmen Cobelo: None declared, Javier Sanchez Perez: None declared, Diego de Argila: None declared, Esteban Rubio-Romero: None declared, MANUEL LEON LUQUE: None declared, Juan María Blanco-Madrigal: None declared, E. Galindez: None declared, Javier Martin Ibanez: None declared, Santos Castañeda: None declared, Ricardo Blanco Speakers bureau: Abbvie, Pfizer, Roche, Bristol-Myers, Janssen and MSD, Consultant of: Abbvie, Pfizer, Roche, Bristol-Myers, Janssen and MSD, Grant/research support from: Abbvie, MSD and Roche, Miguel A González-Gay Speakers bureau: Pfizer, Abbvie, MSD, Grant/research support from: Pfizer, Abbvie, MSD, Raquel López-Mejías: None declared
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Prieto-Peña, D., S. Remuzgo Martinez, F. Genre, V. Pulito-Cueto, B. Atienza-Mateo, B. Sevilla, J. Llorca et al. "POS0113 BAFF-APRIL-BAFFR PATHWAY ON THE PATHOGENESIS OF IMMUNOGLOBULIN-A VASCULITIS". Annals of the Rheumatic Diseases 80, Suppl 1 (19 de mayo de 2021): 267.2–268. http://dx.doi.org/10.1136/annrheumdis-2021-eular.707.
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Background:BAFF, APRIL and BAFFR are genes that encode cytokines with a key role in the development and survival of B-lymphocytes [1-4]: The B cell-activating factor (BAFF, also known as BLyS), a proliferation-inducing ligand (APRIL) and BAFF receptor (BAFF-R), respectively. Previous genetic studies have revealed that the BAFF-APRIL-BAFFR pathway is implicated in the genetic predisposition to several immune-mediated diseases [5].Objectives:To determine whether the BAFF-APRIL-BAFFR pathway represents a novel genetic risk factor for the pathogenesis of Immunoglobulin-A vasculitis (IgAV), an inflammatory disease in which IgA deposits and B-lymphocytes are crucial [6, 7].Methods:A functional BAFF polymorphism (rs374039502) and two tag variants within APRIL (rs11552708 and rs6608) and BAFFR (rs7290134 and rs77874543) were genotyped in 386 Caucasian IgAV patients (the largest series of Caucasian patients with IgAV ever assessed for genetic studies) and 806 sex and ethnically matched healthy controls by TaqMan assays.Results:No statistically significant differences in the genotype and allele frequencies between patients with IgAV and healthy controls were observed when each genetic variant of BAFF APRIL and BAFFR was analyzed independently (Table 1). Likewise, no statistically significant differences in genotype and allele frequencies of BAFF APRIL or BAFFR were found when patients with IgAV were stratified according to the age at disease onset or to the presence/absence of gastrointestinal or renal manifestations. Similar results were disclosed when haplotype frequencies of APRIL and BAFFR were compared between patients with IgAV and healthy controls as well as patients with IgAV stratified according to the age at disease onset or to the presence/absence of gastrointestinal or renal manifestations.Conclusion:Our results suggest that the BAFF-APRIL-BAFFR pathway does not contribute to the genetic network underlying IgAV.References:[1]J Exp Med 1999;190:1697-710; [2] Science 1999;285:260-3; [3] Nat Genet 2005;37:829-34; [4] Nat Immunol 2002;3:822-9; [5] N Engl J Med 2017;376:1615-26; [6] N Engl J Med 2013;368:2402-14; [7] Autoimmun Rev 2018;17:301-315.Table 1.Genotype and allele frequencies of BAFF, APRIL and BAFFR genes in patients with IgA vasculitis and healthy controls.PolymorphismLocus1/2Data set1/11/22/212rs374039502BAFFT/APatients91.9 (353)8.1 (31)095.9 (737)4.1 (31)Controls91.5 (733)8.1 (65)0.4 (3)95.6 (1531)4.4 (71)rs11552708APRILG/APatients78.1 (299)20.6 (79)1.3 (5)88.4 (677)11.6 (89)Controls77.9 (625)20.4 (1641.6 (13)88.1 (1414)11.9 (190)rs6608APRILC/TPatients71.9 (277)26.0 (100)2.1 (8)84.9 (654)15.1 (116)Controls70.0 (561)27.6 (221)2.5 (20)83.7 (1343)16.3 (261)rs7290134BAFFRA/GPatients58.0 (224)36.3 (140)5.7 (22)76.2 (588)23.8 (184)Controls57.2 (459)36.4 (292)6.5 (52)75.3 (1210)24.6 (396)rs77874543BAFFRG/CPatients82.7 (316)16.0 (61)1.3 (5)90.7 (693)9.3 (71)Controls83.0 (666)16.6 (133)0.4 (3)91.3 (1465)8.7 (139)Acknowledgements:This study was supported by European Union FEDER funds and “Fondo de Investigaciones Sanitarias” (grant PI18/00042) from ‘Instituto de Salud Carlos III’ (ISCIII, Health Ministry, Spain). DP-P is a recipient of a Río Hortega programme fellowship from the ISCIII, co-funded by the European Social Fund (ESF, `Investing in your future´) [grant number CM20/00006]; SR-M is supported by funds of the RETICS Program co-funded by the European Regional Development Fund (ERDF) [grant number RD16/0012/0009]; VP-C is supported by a pre-doctoral grant from IDIVAL [grant number PREVAL 18/01]; BA-M is a recipient of a `López Albo´ Post-Residency Programme funded by Servicio Cántabro de Salud; LL-G is supported by funds of IDIVAL [grant number INNVAL20/06]; RL-M is a recipient of a Miguel Servet type I programme fellowship from the ISCIII, co-funded by the European Social Fund (ESF, `Investing in your future´) [grant number CP16/00033].Disclosure of Interests:Diana Prieto-Peña Speakers bureau: Abbvie, Pfizer, Roche, Bristol-Myers, Janssen and MSD, Consultant of: Abbvie, Pfizer, Roche, Bristol-Myers, Janssen and MSD, Grant/research support from: Abbvie, MSD and Roche, Sara Remuzgo Martinez: None declared, Fernanda Genre: None declared, Verónica Pulito-Cueto: None declared, Belén Atienza-Mateo: None declared, Belén Sevilla: None declared, Javier Llorca: None declared, Norberto Ortego: None declared, Leticia Lera-Gómez: None declared, Maite Leonardo: None declared, Ana Peñalba: None declared, J. Narváez: None declared, Luis Martín-Penagos: None declared, Jose Alberto Miranda-Filloy: None declared, LUIS CAMINAL MONTERO: None declared, PAZ COLLADO: None declared, Javier Sanchez Perez: None declared, Diego de Argila: None declared, Esteban Rubio-Romero: None declared, MANUEL LEON LUQUE: None declared, Juan María Blanco-Madrigal: None declared, E. Galindez: None declared, Javier Martin Ibanez: None declared, Santos Castañeda: None declared, Ricardo Blanco Speakers bureau: Abbvie, Pfizer, Roche, Bristol-Myers, Janssen and MSD, Consultant of: Abbvie, Pfizer, Roche, Bristol-Myers, Janssen and MSD, Grant/research support from: Abbvie, MSD and Roche, Miguel A González-Gay Speakers bureau: Pfizer, Abbvie, MSD, Grant/research support from: Pfizer, Abbvie, MSD, Raquel López-Mejías: None declared
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Reyes Martínez, Amelia, Juan Carlos Castro Ramírez y Guillermo Martínez Atilano. "Transferencia y conservación de la infraestructura hidroagrícola en el Alto Río Lerma, Guanajuato". Entreciencias: Diálogos en la Sociedad del Conocimiento 7, n.º 20 (31 de julio de 2019). http://dx.doi.org/10.22201/enesl.20078064e.2019.20.69247.
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<div class="page" title="Page 1"><div class="layoutArea"><div class="column"><p><span><strong>Objetivo - </strong></span><span>evaluar el estado de conservación de la infraestructura hidroagrícola, como resultado del proceso de transferencia a los usuarios del D.R. 011.</span></p><p><strong>Método - </strong><span>análisis estadístico de series de tiempo de las variables de inversión en mantenimiento y conservación, cuotas de riego y volúmenes de agua disponible para riego en el D.R. 011.</span></p><p><strong>Resultados - </strong>la inversión en conservación y mantenimiento no presenta una tendencia creciente en el período posterior al proceso de transferencia, no obstante que se incrementaron las cuotas de riego pagadas por los usuarios, lo que ha incidido negativamente en el estado físico de las obras.</p><p><strong>Limitaciones - </strong>no hay información disponible suficiente para realizar el análisis estadístico de cada uno de los módulos estudiados.</p><p><strong>Principales hallazgos - </strong>a más de dos décadas de la transferencia del manejo de las obras a los usuarios del D.R. 011, las estructuras de riego presentan un notable deterioro, particularmente los módulos Valle de Santiago y Cortázar, donde gran parte de los canales de distribución de la red menor, se encuentran sin revestir y en malas condiciones.</p></div></div></div>
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Didenko, V. E., O. A. Gelfond, A. V. Korybut y M. A. Vasiliev. "Spin-locality of η2 and $$ {\overline{\eta}}^2 $$ quartic higher-spin vertices". Journal of High Energy Physics 2020, n.º 12 (diciembre de 2020). http://dx.doi.org/10.1007/jhep12(2020)184.
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Abstract Higher-spin theory contains a complex coupling parameter η. Different higher-spin vertices are associated with different powers of η and its complex conjugate $$ \overline{\eta} $$ η ¯ . Using Z-dominance Lemma of [1], that controls spin-locality of the higher-spin equations, we show that the third-order contribution to the zero-form B(Z; Y; K) admits a Z-dominated form that leads to spin-local vertices in the η2 and $$ {\overline{\eta}}^2 $$ η ¯ 2 sectors of the higher-spin equations. These vertices include, in particular, the η2 and $$ {\overline{\eta}}^2 $$ η ¯ 2 parts of the ϕ4 scalar field vertex.
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Salahudden, Vijay S. Dwivedi, Prasiddha N. Dwivedi, Dipak K. Giri y Ajoy K. Ghosh. "Aircraft flat-spin recovery using sliding-mode based attitude and altitude control". Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering, 22 de octubre de 2020, 095441002096467. http://dx.doi.org/10.1177/0954410020964674.
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In the present paper, a control command to recover steady-straight-level flight from flat-oscillatory-stable-left-spin is developed using a sliding-mode based attitude and altitude control. Direct spin recovery, using a spin solution by bifurcation results, to low angle-of-attack is achieved in finite-time without any separation in dynamics. The exponential convergence of errors is discussed by invoking Barbalat’s Lemma theorem. Thereafter settling time is obtained thereby making the system a finite-time stable to reach the sliding surface. The novelty of this work lies in the proposed control strategy, wherein expressions for all four primary control inputs are obtained in a closed-loop form without any approximation and altitude margin required for flat-spin recovery is investigated based on a heuristic approach for a fixed controller gains. Additionally, results of this research indicate the proposed controller first stops the spin by controlling the attitude of the aircraft thereby rotation stops about the body axis and then reaches the commanded altitude to attain the horizontal flight.
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Peng, Yuejian, Vojtech Rödl y Andrzej Ruciński. "Holes in Graphs". Electronic Journal of Combinatorics 9, n.º 1 (14 de octubre de 2001). http://dx.doi.org/10.37236/1618.
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The celebrated Regularity Lemma of Szemerédi asserts that every sufficiently large graph $G$ can be partitioned in such a way that most pairs of the partition sets span $\epsilon$-regular subgraphs. In applications, however, the graph $G$ has to be dense and the partition sets are typically very small. If only one $\epsilon$-regular pair is needed, a much bigger one can be found, even if the original graph is sparse. In this paper we show that every graph with density $d$ contains a large, relatively dense $\epsilon$-regular pair. We mainly focus on a related concept of an $(\epsilon,\sigma)$-dense pair, for which our bound is, up to a constant, best possible.
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Gelfond, O. A. y A. V. Korybut. "Manifest form of the spin-local higher-spin vertex $$\varUpsilon ^{\eta \eta }_{\omega CCC}$$". European Physical Journal C 81, n.º 7 (julio de 2021). http://dx.doi.org/10.1140/epjc/s10052-021-09401-4.
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AbstractVasiliev generating system of higher-spin equations allowing to reconstruct nonlinear vertices of field equations for higher-spin gauge fields contains a free complex parameter $$\eta $$ η . Solving the generating system order by order one obtains physical vertices proportional to various powers of $$\eta $$ η and $${\bar{\eta }}$$ η ¯ . Recently $$\eta ^2$$ η 2 and $${\bar{\eta }}^2$$ η ¯ 2 vertices in the zero-form sector were presented in Didenko et al. (JHEP 2012:184, 2020) in the Z-dominated form implying their spin-locality by virtue of Z-dominance Lemma of Gelfond and Vasiliev (Phys. Lett. B 786:180, 2018). However the vertex of Didenko et al. (2020) had the form of a sum of spin-local terms dependent on the auxiliary spinor variable Z in the theory modulo so-called Z-dominated terms, providing a sort of existence theorem rather than explicit form of the vertex. The aim of this paper is to elaborate an approach allowing to systematically account for the effect of Z-dominated terms on the final Z-independent form of the vertex needed for any practical analysis. Namely, in this paper we obtain explicit Z-independent spin-local form for the vertex $$\varUpsilon ^{\eta \eta }_{\omega CCC}$$ Υ ω C C C η η for its $$\omega CCC$$ ω C C C -ordered part where $$\omega $$ ω and C denote gauge one-form and field strength zero-form higher-spin fields valued in an arbitrary associative algebra in which case the order of product factors in the vertex matters. The developed formalism is based on the Generalized Triangle identity derived in the paper and is applicable to all other orderings of the fields in the vertex.
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Brullo, Salvatore, Cristian Brullo, Salvatore Cambria, Gianmarco Tavilla, Gianpietro Giusso del Galdo y Sandro Bogdanović. "Taxonomical and chorological remarks on the Mediterranean Poa maroccana (Poaceae) and first record in Italy from Sicilian flora". Acta botanica Croatica 80, n.º 1 (6 de octubre de 2020). http://dx.doi.org/10.37427/botcro-2021-011.
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Poa maroccana is an annual Mediterranean species, which is recorded for the first time from Sicily and for the whole Italian territory. It usually occurs in synanthopic habitats, represented mainly by urban and suburban roadsides, where it is quite sporadic. Based on current knowledge, it has been hitherto reported only in a few localities of the Mediterranean area, particularly in Morocco, Algeria, Tunisia, Libya, Spain, Portugal, Greece, Turkey, Syria and Crimea. Field observations and herbarium investigations have shown that this species is often mistaken for P. annua, mainly due to its morphological similarities, as well as for the same ecological needs, therefore its real geographical distribution has yet to be verified. Although the two species are both tetraploids (2n = 28), they clearly differ for numerous relevant features concerning the shape and size of ligules, inflorescence, spikelet, glumes, palea, lemma, anthers, lodicules and seed. In order to better clarify the relationships of P. maroccana with P. annua and the other annual species of this genus occurring in the Mediterranean, its carefull a morphological description and iconography is provided, as well as a comparative morphological table of all allied species and also their analytical key for easy identification.
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ORPONEN, TUOMAS. "Combinatorial proofs of two theorems of Lutz and Stull". Mathematical Proceedings of the Cambridge Philosophical Society, 15 de febrero de 2021, 1–12. http://dx.doi.org/10.1017/s0305004120000328.
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Abstract Recently, Lutz and Stull used methods from algorithmic information theory to prove two new Marstrand-type projection theorems, concerning subsets of Euclidean space which are not assumed to be Borel, or even analytic. One of the theorems states that if \[K \subset {\mathbb{R}^n}\] is any set with equal Hausdorff and packing dimensions, then \begin{equation} \[{\dim _{\text{H}}}{\pi _e}(K) = \min \{ {\dim _{\text{H}}}{\text{ }}K{\text{, 1}}\} \] \end{equation} for almost every \[e \in {S^{n - 1}}\] . Here \[{\pi _e}\] stands for orthogonal projection to span ( \[e\] ). The primary purpose of this paper is to present proofs for Lutz and Stull’s projection theorems which do not refer to information theoretic concepts. Instead, they will rely on combinatorial-geometric arguments, such as discretised versions of Kaufman’s “potential theoretic” method, the pigeonhole principle, and a lemma of Katz and Tao. A secondary purpose is to generalise Lutz and Stull’s theorems: the versions in this paper apply to orthogonal projections to m-planes in \[{\mathbb{R}^n}\] , for all \[0 < m < n\] .
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Lewintan, Peter, Stefan Müller y Patrizio Neff. "Korn inequalities for incompatible tensor fields in three space dimensions with conformally invariant dislocation energy". Calculus of Variations and Partial Differential Equations 60, n.º 4 (2 de julio de 2021). http://dx.doi.org/10.1007/s00526-021-02000-x.
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AbstractLet $$\Omega \subset \mathbb {R}^3$$ Ω ⊂ R 3 be an open and bounded set with Lipschitz boundary and outward unit normal $$\nu $$ ν . For $$1<p<\infty $$ 1 < p < ∞ we establish an improved version of the generalized $$L^p$$ L p -Korn inequality for incompatible tensor fields P in the new Banach space $$\begin{aligned}&W^{1,\,p,\,r}_0({{\,\mathrm{dev}\,}}{{\,\mathrm{sym}\,}}{{\,\mathrm{Curl}\,}}; \Omega ,\mathbb {R}^{3\times 3}) \\&\quad = \{ P \in L^p(\Omega ; \mathbb {R}^{3 \times 3}) \mid {{\,\mathrm{dev}\,}}{{\,\mathrm{sym}\,}}{{\,\mathrm{Curl}\,}}P \in L^r(\Omega ; \mathbb {R}^{3 \times 3}),\ {{\,\mathrm{dev}\,}}{{\,\mathrm{sym}\,}}(P \times \nu ) = 0 \text { on }\partial \Omega \} \end{aligned}$$ W 0 1 , p , r ( dev sym Curl ; Ω , R 3 × 3 ) = { P ∈ L p ( Ω ; R 3 × 3 ) ∣ dev sym Curl P ∈ L r ( Ω ; R 3 × 3 ) , dev sym ( P × ν ) = 0 on ∂ Ω } where $$\begin{aligned} r \in [1, \infty ), \qquad \frac{1}{r} \le \frac{1}{p} + \frac{1}{3}, \qquad r >1 \quad \text {if }p = \frac{3}{2}. \end{aligned}$$ r ∈ [ 1 , ∞ ) , 1 r ≤ 1 p + 1 3 , r > 1 if p = 3 2 . Specifically, there exists a constant $$c=c(p,\Omega ,r)>0$$ c = c ( p , Ω , r ) > 0 such that the inequality $$\begin{aligned} \Vert P \Vert _{L^p(\Omega ,\mathbb {R}^{3\times 3})}\le c\,\left( \Vert {{\,\mathrm{sym}\,}}P \Vert _{L^p(\Omega ,\mathbb {R}^{3\times 3})} + \Vert {{\,\mathrm{dev}\,}}{{\,\mathrm{sym}\,}}{{\,\mathrm{Curl}\,}}P \Vert _{L^{r}(\Omega ,\mathbb {R}^{3\times 3})}\right) \end{aligned}$$ ‖ P ‖ L p ( Ω , R 3 × 3 ) ≤ c ‖ sym P ‖ L p ( Ω , R 3 × 3 ) + ‖ dev sym Curl P ‖ L r ( Ω , R 3 × 3 ) holds for all tensor fields $$P\in W^{1,\,p, \, r}_0({{\,\mathrm{dev}\,}}{{\,\mathrm{sym}\,}}{{\,\mathrm{Curl}\,}}; \Omega ,\mathbb {R}^{3\times 3})$$ P ∈ W 0 1 , p , r ( dev sym Curl ; Ω , R 3 × 3 ) . Here, $${{\,\mathrm{dev}\,}}X :=X -\frac{1}{3} {{\,\mathrm{tr}\,}}(X)\,{\mathbb {1}}$$ dev X : = X - 1 3 tr ( X ) 1 denotes the deviatoric (trace-free) part of a $$3 \times 3$$ 3 × 3 matrix X and the boundary condition is understood in a suitable weak sense. This estimate also holds true if the boundary condition is only satisfied on a relatively open, non-empty subset $$\Gamma \subset \partial \Omega $$ Γ ⊂ ∂ Ω . If no boundary conditions are imposed then the estimate holds after taking the quotient with the finite-dimensional space $$K_{S,dSC}$$ K S , d S C which is determined by the conditions $${{\,\mathrm{sym}\,}}P =0$$ sym P = 0 and $${{\,\mathrm{dev}\,}}{{\,\mathrm{sym}\,}}{{\,\mathrm{Curl}\,}}P = 0$$ dev sym Curl P = 0 . In that case one can replace $$\Vert {{\,\mathrm{dev}\,}}{{\,\mathrm{sym}\,}}{{\,\mathrm{Curl}\,}}P \Vert _{L^r(\Omega ,\mathbb {R}^{3\times 3})} $$ ‖ dev sym Curl P ‖ L r ( Ω , R 3 × 3 ) by $$\Vert {{\,\mathrm{dev}\,}}{{\,\mathrm{sym}\,}}{{\,\mathrm{Curl}\,}}P \Vert _{W^{-1,p}(\Omega ,\mathbb {R}^{3\times 3})}$$ ‖ dev sym Curl P ‖ W - 1 , p ( Ω , R 3 × 3 ) . The new $$L^p$$ L p -estimate implies a classical Korn’s inequality with weak boundary conditions by choosing $$P=\mathrm {D}u$$ P = D u and a deviatoric-symmetric generalization of Poincaré’s inequality by choosing $$P=A\in {{\,\mathrm{\mathfrak {so}}\,}}(3)$$ P = A ∈ so ( 3 ) . The proof relies on a representation of the third derivatives $$\mathrm {D}^3 P$$ D 3 P in terms of $$\mathrm {D}^2 {{\,\mathrm{dev}\,}}{{\,\mathrm{sym}\,}}{{\,\mathrm{Curl}\,}}P$$ D 2 dev sym Curl P combined with the Lions lemma and the Nečas estimate. We also discuss applications of the new inequality to the relaxed micromorphic model, to Cosserat models with the weakest form of the curvature energy, to gradient plasticity with plastic spin and to incompatible linear elasticity.
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Tanure, Aleixo Abreu, Roberto Barreto Maia, Thiago Alencar Fortaleza, Luis Guilherme Rosifini Alves Rezende, Adriana Vieira Pedreira Cabral y Rogério Meira Barros. "Concordância interobservador na avaliação de lesões do tendão subescapular usando imagens de Ressonância Nuclear Magnética". ARCHIVES OF HEALTH INVESTIGATION 8, n.º 1 (22 de abril de 2019). http://dx.doi.org/10.21270/archi.v8i1.3821.
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Introdução: As lesões do tendão musculo subescapular (TMSE) do manguito rotador passaram a ter aumento de sua incidência com as avançadas técnicas de diagnostico por imagem e artroscópicas. A Ressonância Nuclear Magnética (RM) apresenta boa sensibilidade e especificidade permitindo adequada acurácia diagnóstico. Objetivo: avaliação da concordância interobservador da RM para Lesões do TMSE comparada à artroscopia. Métodologia: 49 pacientes sintomáticos foram submetidos à RM para diagnóstico de lesão do TMSE e avaliação da Classificação de Lafosse, tendo sua concordância avaliada através da Artroscopia diagnostica. Resultados: A acurácia global foi 68% para concordância diagnóstica da Lesão do TMSE e 57,1% para concordância na classificação de Lafosse. Discussão: obteve-se concordância para o diagnóstico de Lesão ou ausência de Lesão do TMSE de 0,49 e a concordância para a Classificação de Lafosse foi de 0,30. Conclusão: o diagnóstico da lesão do TMSE através da RM é de difícil realização.Descritores: Manguito Rotador; Artroscopia; Imagem por Ressonância Magnética.ReferênciasTicker JB, Warner JJ. Single-tendon tears of the rotator cuff: evaluation and treatment of subscapularis tears and principles of treatment for supraspinatus tears. Orthop Clin North Am. 1997; 28(1):99-116. Codman EA. Rupture of the supraspinatus tendon and other lesions in or about the subacromial bursa. The Shoulder. 2nd Ed. Boston: Thomas Todd; 1934. p. 262-312. Deutsch A, Altchek DW, Veltri DM, Potter HG, Warren RF. Traumatic tears of the subscapularis tendon. Clinical diagnosis, magnetic resonance imaging findings, and operative treatment. Am J Sports Med. 1997;25(1):13-22.Li XX, Schweitzer ME, Bifano JA, Lerman J, Manton GL, El-Noueam KI. MR evaluation of subscapularis tears. J Comput Assist Tomogr. 1999;23(5):713-17. Adams CR, Schoolfield JD, Burkhart SS. Accuracy of preoperative magnetic resonance imaging in predicting a subscapularis tendon tear based on arthroscopy. Arthroscopy. 2010;26(11):1427-33.Adams CR, Brady PC, Koo SS, Narbona P, Arrigoni P, Karnes GJ et al. A systematic approach for diagnosing subscapularis tendon tears with preoperative magnetic resonance imaging scans. Arthroscopy. 2012; 28(11):1592-600.Pfirrmann CWA, Zanetti M, Weishaupt D, Gerber C, Hodler J. Subscapularis tendon tears: Detection and grading at MR ar- thrography. Radiology. 1999; 213:709-714.Yoon JP, Chung SW, Kim SH, Oh JH. Diagnostic value of four clinical tests for the evaluation of subscapularis integrity. J Shoulder Elbow Surg. 2013;22(9):1186-92.Beltran J. The use of magnetic resonance imaging about the shoulder. J Shoulder Elbow Surg. 1992; 1(6):321-33.Houtz CG, Schwartzberg RS, Barry JA, Reuss BL, Papa L. Shoulder MRI accuracy in the community setting. J Shoulder Elbow Surg. 2011; 20(4):537-42.Burks RT, Crim J, Brown N, Fink B, Greis PE. A prospective randomized clinical trial comparing arthroscopic single- and double-row rotator cuff repair: magnetic resonance imaging and early clinical evaluation. Am J Sports Med. 2009;37(4):674-82. Gyftopoulos S, O' Donnell J, Shah NP, Goss J, Babb J, Recht MP. Correlation of MRI with arthroscopy for the evaluation of the subscapularis tendon: a musculoskeletal division’s experience. Skeletal Radiol. 2013;42(9):1269-75.Pfirrmann CW1, Zanetti M, Weishaupt D, Gerber C, Hodler J. Subscapularis tendon tears: detection and grading at MR arthrography. Radiology. 1999;213(3):709-14.Spencer EE Jr, Dunn WR, Wright RW, Wolf BR, Spindler KP, McCarty E et al. Interobserver agreement in the classification of rotator cuff tears using magnetic resonance imaging. Am J Sports Med. 2008;36(1):99-103.Toussaint B, Barth J, Charousset C, Godeneche A, Joudet T, Lefebvre Y et al. New endoscopic classification for subscapularis lesions. Orthop Traumatol Surg Res. 2012;98(8 Suppl):S186-92.Lafosse L, Jost B, Reiland Y, Audebert S, Tousaint B, Gobezie R. Structural integrity and clinical outcomes after arthroscopic repair of isolated subescapularis tears. J Bone Joint Surg Am. 2007;89(6):1184-93.Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33(1):159-74.Balich SM, Sheley RC, Brown TR, Sauser DD, Quinn SF. MR imaging of the rotator cuff tendon: interobserver agreement and analysis of interpretive errors. Radiology. 1997; 204(1):191-94.Robertson PL, Schweitzer ME, Mitchell DG, Schlesinger F, Epstein RE, Frieman BG et al. Rotator cuff disor- ders: interobserver and intraobserver variation in diagnosis with MR imaging. Radiology. 1995;194(3):831-35.Singson RD, Hoang T, Dan S, Friedman M. MR evaluation of rotator cuff pathology using T2-weighted fast spin-echo technique with and without fat suppression. AJR Am J Roentgenol. 1996; 166:1061-65.Szymanski C1, Staquet V, Deladerrière JY, Vervoort T, Audebert S, Maynou C. Reproducibility and reliability of subscapularis tendon assessment using CT-arthrography. Orthop Traumatol Surg Res. 2013;99(1):2-9.