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Tesis sobre el tema "LL-37"

Autor: Grafiati
Publicado: 4 de junio de 2021
Última modificación: 25 de julio de 2025

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1

Filewod, Niall Christopher Jack. "Immunomodulatory effects of LL-37 in the epithelia." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/927.

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The cationic host defence peptide LL-37 is an immunomodulatory agent that plays an important role in epithelial innate immunity. Previously, concentrations of LL-37 thought to represent levels present during inflammation have been shown to elicit the production of cytokines and chemokines by epithelial cells. To investigate the potential of lower concentrations of LL-37 to alter epithelial cell responses, normal primary keratinocytes and bronchial epithelial cells were treated with pro-inflammatory stimuli in the presence or absence of 1 – 3 μg/ml LL-37. Low, physiologically relevant concentra
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2

El, Abbouni Sarah. "Microencapsulation of LL-37 Antimicrobial Peptide in PLGA." Digital WPI, 2016. https://digitalcommons.wpi.edu/etd-theses/235.

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Antimicrobial peptides are key actors in organisms€™ immune systems. They play an important role in phagocytosis, breaking bacteria membranes. They destroy the microbes, keeping them from repairing themselves, and therefore do not promote antimicrobial resistance. LL37 is a peptide produced by the human body. It is a short amino acid chain that is particularly active on the skin and mucous membranes. It has antimicrobial and fungal activity as well as wound healing properties, which makes it a very interesting active substance in wound treatment. However, its fragile and sensitive structure i
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3

Currie, Silke Maria. "Antiviral function of LL-37 on respiratory syncytial virus." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25954.

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Recurrent infection with human respiratory syncytial virus (RSV) is one of the most common causes for lower respiratory tract illness (LRI) in infants, the elderly, and immunocompromised individuals. Due to lack of vaccines and therapeutic interventions, medical care of acute RSV bronchiolitis is mostly limited to supportive measures. Thus, novel treatment options to control RSV infection are desperately required. The cationic host defence peptide human cathelicidin LL-37 possesses both microbicidal and immunomodulatory properties. This essential effector of the innate immune system holds pote
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4

Frew, Lorraine. "The production and function of cervical hCAP18/LL-37 in pregnancy." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/18000.

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Antimicrobial peptides (AMPs) are small proteins produced by epithelial surfaces, which have broad-spectrum antimicrobial and immunomodulatory activities. In the lung, skin and alimentary tract AMPs are known to be important in infectious and inflammatory conditions. Far less is known regarding the role of AMPs within the female reproductive tract, but as infection and inflammation are causes of preterm labour, AMPs may have a key function in maintain and protecting pregnancy. The major groups of human AMPs include the human beta defensins (HBDs), two antileukoproteinases (secretory leukocyte
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5

Oliveira, Junior Luiz Roberto de. "Vitamina D e LL-37 em Pacientes com Doença de Chagas." Botucatu, 2018. http://hdl.handle.net/11449/153022.

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Orientador: Cilmery Suemi Kurokawa<br>Resumo: O texto apresentado faz parte dos estudos sobre doença de Chagas (DC), suas formas clínicas e correlação com morbidades associadas à obesidade e envelhecimento e confeccionado para obtenção do título de Mestre em Doenças Tropicais. Ele é dividido em dois capítulos, no qual o primeiro texto compreende uma revisão bibliográfica sobre a doença de Chagas, vitamina D3 e catelicidina LL-37; e, no segundo capítulo, um artigo com dados descritivos da população de estudo intitulado de “FATORES DE RISCO CARDIOVASCULAR ASSOCIADOS À DOENÇA DE CHAGAS CRÔNICA” e
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6

Carlsson, Martin, and Johan Humlén. "Effekter av den antimikrobiella peptiden LL-37 på humana osteoblasters viabilitet." Thesis, Malmö högskola, Odontologiska fakulteten (OD), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-19902.

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Den antimikrobiella peptiden LL-37 finns uttryckt i alla kroppens slemhinnor och lagras i stora mängder i sekundära granula hos neutrofiler och monocyter. Förutom dess antimikrobiella effekt uppvisar LL-37 pro- alternativt anti-apoptotisk effekt på eukaryota celler beroende på celltyp. I denna studie visar vi för första gången den pro-apoptotiska effekten av LL-37 på den humana osteoblastcellinjen MG63. Vid stimulering med 4μM iakttogs en reduktion av cellantalet med 40% och en utbredd celldöd kunde fastställas genom Trypan Blue-infärgning. Genom flödescytometri sågs en förhöjd andel annexin V
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7

Scott, Aaron. "Functional studies of the human antimicrobial proteins LL-37 and Eppin." Thesis, Queen's University Belfast, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.546424.

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8

Cassin, Margaret Emily. "The Design of Antimicrobial Detachable Thin Films for the Study of Hepatic Infections." Thesis, Virginia Tech, 2015. http://hdl.handle.net/10919/77426.

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Microbial infections are a global problem. Due to the over and misuse of antibiotics, drug-resistant pathogens are becoming more common. It is imperative to explore broad spectrum antimicrobial approaches. In this work, we modified collagen/hyaluronic acid polyelectrolyte multilayers (PEMs) with the natural antimicrobial peptide, LL-37 to study hepatic infections. LL-37 was physisorbed and covalently linked to the surface of the PEMs. Escherichia coli DH10B were cultured in the presence of LL-37modified PEMs in bacterial adhesion and contact killing models. Physisorbed LL-37 PEMs prevented ba
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9

Dannehl, Claudia. "Fragments of the human antimicrobial LL-37 and their interaction with model membranes." Phd thesis, Universität Potsdam, 2013. http://opus.kobv.de/ubp/volltexte/2013/6814/.

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A detailed description of the characteristics of antimicrobial peptides (AMPs) is highly demanded, since the resistance against traditional antibiotics is an emerging problem in medicine. They are part of the innate immune system in every organism, and they are very efficient in the protection against bacteria, viruses, fungi and even cancer cells. Their advantage is that their target is the cell membrane, in contrast to antibiotics which disturb the metabolism of the respective cell type. This allows AMPs to be more active and faster. The lack of an efficient therapy for some cancer types and
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10

Neto, Guilherme Tude Coelho. "Peptídeo antimicrobiano LL-37 e seus efeitos em stemness de diferentes células tumorais." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5164/tde-06032017-104147/.

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Os peptídeos antimicrobianos desempenham papéis protetores críticos em uma gama de doenças humanas, incluindo o câncer. Vários estudos demonstraram funções - tais como proliferação, angiogênese, apoptose e imunomodulação - desses peptídeos em vias cancerígenas cruciais. Investigamos o papel do Peptídeo antimicrobiano LL-37 sobre stemness em câncer de mama (SKBR3) e células de melanoma (A375). Análise por PCR array da expressão diferencial de genes em SKBR3 e A375 com knockdown por siRNA para o mRNA de LL-37 revelou uma regulação negativa de genes relacionados com stemness, incluindo transcript
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11

Milhan, Noala Vicensoto Moreira [UNESP]. "Avaliação do peptídeo LL-37 em contato com células-tronco da polpa dentária." Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/149791.

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Submitted by NOALA VICENSOTO MOREIRA MILHAN null (noalinha@gmail.com) on 2017-03-14T15:32:19Z No. of bitstreams: 1 TESE_FINAL_biblioteca_pdf_com ficha..pdf: 9569489 bytes, checksum: 1675ea8facc1f735605660b0b01b8cad (MD5)<br>Approved for entry into archive by Juliano Benedito Ferreira (julianoferreira@reitoria.unesp.br) on 2017-03-20T22:29:35Z (GMT) No. of bitstreams: 1 milhan_nvm_dr_sjc.pdf: 9569489 bytes, checksum: 1675ea8facc1f735605660b0b01b8cad (MD5)<br>Made available in DSpace on 2017-03-20T22:29:36Z (GMT). No. of bitstreams: 1 milhan_nvm_dr_sjc.pdf: 9569489 bytes, checksum: 1675ea8fa
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12

Milhan, Noala Vicensoto Moreira. "Avaliação do peptideo LL-37 em contato com células-tronco da polpa dentária /." São José dos Campos, 2017. http://hdl.handle.net/11449/149791.

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Orientador: Samira Esteves Afonso Camargo<br>Banca: Luana Marotta Reis de Vasconcellos<br>Banca: Mônica Ghislaine Oliveira Alves<br>Banca: Cristina Pacheco Soares<br>Banca: Cacio de Moura Netto<br>Resumo: O peptídeoLL-37 (catelicidina derivada de humano), é liberado por algumas células humanas e capaz de neutralizar os tecidos com lipopolissacarídeo (LPS), além de atrair células da polpa, e induzir a angiogênese, características que o tornam um possível adjunto para a regeneração do complexo dentino-pulpar. O objetivo desse trabalho foi avaliar in vitro a biocompatibilidade do peptídeo LL-37 n
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13

Li, Yue Xin. "The human cationic host defense peptide LL-37 modulates neutrophil apoptosis and chemokine responses." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/31726.

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LL-37 is a human cationic peptide expressed primarily by neutrophils and epithelial cells. It is a 37 amino acid peptide that belongs to the cathelicidin family of the cationic host defense peptides. Accumulating evidence has demonstrated that LL-37 has multiple immunomodulatory properties. The modulatory effects of LL-37 on neutrophils were investigated here, and LL-37 was shown to be a potent inhibitor of spontaneous apoptosis in human neutrophils, signalling through P2X₇ receptors and G-protein-coupled receptors other than the formyl peptide receptor-like- 1 molecule. Inhibition of ne
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14

Zhang, P. "Identification of staphylococcal genes involved in resistance to the human antimicrobial peptide LL-37." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1380282/.

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Staphylococcus aureus is well-known for its ability to acquire resistance to a broad range of antimicrobial agents and a limited number of commercially available antibiotics exist that are active against multidrug resistant strains. Antimicrobial peptides have been suggested as promising alternatives to current antimicrobials due to their potent antimicrobial activity against a broad range of microorganisms including multidrug resistant bacteria, and a membrane-lytic mode of action that is thought to have low possibility of inducing bacterial resistance. This study describes the identification
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15

Bravo, Martha de Oliveira. "Efeito do peptídeo catelicidina LL-37 sobre a propriedade imunossupressora das células-tronco mesenquimais." reponame:Repositório Institucional da UnB, 2016. http://repositorio.unb.br/handle/10482/21629.

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Dissertação (mestrado)—Universidade de Brasília, Faculdade de Medicina, Programa de Pós-Graduação em Patologia Molecular, 2016.<br>Submitted by Fernanda Percia França (fernandafranca@bce.unb.br) on 2016-08-17T17:33:43Z No. of bitstreams: 1 2016_MarthadeOliveiraBravo.pdf: 17501557 bytes, checksum: 0f490dec5aa9501399b157cb3a253bcc (MD5)<br>Approved for entry into archive by Raquel Viana(raquelviana@bce.unb.br) on 2016-10-31T15:58:56Z (GMT) No. of bitstreams: 1 2016_MarthadeOliveiraBravo.pdf: 17501557 bytes, checksum: 0f490dec5aa9501399b157cb3a253bcc (MD5)<br>Made available in DSpace on 2016-10-
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16

Ghannad, Mona. "Design and Synthesis of Collagen-binding Anti-microbial Proteins." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/19981.

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The Herpes simplex virus (HSV) is a virus that commonly infects the skin, and mucous membrane of the mouth, genitalia, and the eye. HSV-1 is the strain that is most commonly associated with corneal infections, and it is the most frequent cause of corneal blindness in North America [1]. Currently no cure is available, and many limitations are characterized by the currently available synthetic antiviral drugs, which suggest the need for other potential drug alternatives and delivery strategies. Anti-microbial peptides are naturally occurring peptides that are potent killers of a broad range of m
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17

Li, Hsin-Ni. "Impact of cationic host defence peptide LL-37 on human neutrophil death and inflammatory responses." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5597.

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Cathelicidins are cationic host defence peptides (CHDP) with essential roles in the innate defence system. These peptides have antimicrobial potential and the capacity to modulate innate immunity and inflammatory processes. Neutrophils (PMN) are the main reservoir of cathelicidins and play key roles in first line defence against infection. The appropriate regulation of PMN function, death, and clearance is critical to innate immunity, and the efferocytosis of apoptotic PMN, in contrast to necrotic cells, is proposed to promote the resolution of inflammation. In this thesis I demonstrate that t
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18

Jackson, Alexander Rodney. "Pharmacological Evaluation of Cyanoguanidine P2X7 Receptor Antagonists." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/17186.

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ABSTRACT BACKGROUND AND AIMS: The P2X7 receptor (P2X7R) is an ATP-gated, non-selective cation channel highly expressed on monocytes, macrophages and microglia. Prolonged activation of the P2X7R by ATP leads to cytolytic pore formation and the release of inflammatory mediators including interleukin-1β and prostaglandin E2. Accumulating evidence suggests a role for the P2X7R in neuroinflammation and thus P2X7R antagonists might be useful in diseases including chronic pain, depression and Alzheimer’s disease. Both negative allosteric modulators of the P2X7R, such as the adamantyl benzamides, and
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19

Andrault, Pierre-Marie. "Rôle des cathepsines à cystéine dans la régulation du peptide antimicrobien LL-37 lors de pathologies inflammatoire chroniques pulmonaires." Thesis, Tours, 2015. http://www.theses.fr/2015TOUR4035/document.

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Lors de pathologies pulmonaires inflammatoires chroniques comme la mucoviscidose ou la BPCO, le déséquilibre de la balance protéases/antiprotéases aboutit à la dégradation du tissu pulmonaire et à l’inactivation des défenses antimicrobiennes. Les cathepsines à cystéine participent à l’inactivation protéolytique de peptides et protéines antimicrobiens (PAMs) pulmonaires comme le SLPI, la lactoferrine, et les β-défensines HBD-2 et -3 lors de l’emphysème ou de la mucoviscidose. Lors de cette thèse, nous avons étudié la capacité des cathepsines à cystéine B, K, L et S à hydrolyser le peptide LL-37
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20

Yu, Jie. "Immunomoduatory properties of host defence peptide LL-37 during infection and inflammation in human blood cells." Thesis, University of British Columbia, 2006. http://hdl.handle.net/2429/31500.

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The human cathelicidin, LL-37, is a cationic host defence peptide and serves as an essential component of innate immunity. In addition to its modest antimicrobial activity, LL-37 has been demonstrated to be a multifunctional modulator of innate immune responses, although the mechanism(s) of which have not been elucidated. The present study demonstrated that LL-37 could synergistically enhance IL-1β-induced production of cytokines (IL-6, IL-10) and chemokines (MCP-3) in primary human PBMCs. In contrast to the neutralization of LPS-induced secretion of pro-inflammatory cytokines, LL-37 dra
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21

Zreika, Sami. "Etude de l'impact de la protéine antimicrobienne humaine hCAP18/LL-37 sur le cancer du sein." Thesis, Tours, 2011. http://www.theses.fr/2011TOUR4052.

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Le peptide hCAP18/LL-37, une partie de la défense immunitaire innée, a maintenant été reconnu comme multifonctionnelle pour les cellules eucaryotes. Nos études démontrent sa contribution au développement du cancer, montrant qu'il est surexprimé dans la plupart des tumeurs mammaires humaines, active la signalisation la famille de ERBB et augmente le potentiel métastatique des cellules cancéreuses du sein. Notre comparaison des deux lignées du cancer du sein n'a pas révélé de récepteurs communs, mais une structure peptidique identiques mais de chiralité différente est pré requis pour le peptide
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22

Nicholls, Erin Frances. "Immunomodulatory and wound-healing effects of the host defence peptide LL-37 and related innate defence regulators." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/41389.

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LL-37, the only known human cathelicidin peptide, possesses a variety of immunomodulatory properties that extend its role in host defence far beyond its original classification as an antimicrobial peptide. Recently, work has been underway to elucidate signalling pathways initiated by LL-37, with the aim of further understanding this peptide’s role in the immune system. The aim of this study was to further uncover the role of transcription factors during the responses of immune cells to LL-37 and related innate defence regulator peptides. Secondary aims were to investigate potential wound-heali
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23

Дудник, В. М., К. В. Хромих та О. П. Федчишен. "Діагностичне значення вмісту протимікробного пептиду С-кінцевого hCAP18 кателіцидину LL-37 у дітей, хворих на бронхіальну астму". Thesis, Сумський державний університет, 2017. http://essuir.sumdu.edu.ua/handle/123456789/64839.

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Бронхіальна астма (БА) - хронічне алергічне захворювання дихальних шляхів, що проявляється нападами задишки або ядухи, сухим кашлем у відповідь на вплив алергену або на тлі простудного захворювання, фізичного навантаження, емоційного стресу [GINA, 2016]. Відомі два сімейства антимікробних пептидів - кателіцидини та дефензини. Кателіцидини - група антимікробних білків, що володіють N- термінальним сигнальним білком, незмінною кателіновою частиною і структурно постійно змінюваних ділянок. Мають широкий спектр антимікробної та імумономодулюючої активності [Абатуров А. Е., 2011]. Поряд з
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24

Gambade, Audrey. "Rôle du peptide LL-37 dans le cancer du sein : son interaction avec la membrane plasmique stimule l'entrée de calcium et la migration cellulaire par l'activation des canaux ioniques TRPV2 et BKCa." Thesis, Tours, 2015. http://www.theses.fr/2015TOUR3312/document.

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Le peptide antimicrobien LL-37 a été retrouvé surexprimé dans différents types de cancer et plus particulièrement dans le cancer du sein dans lequel il est associé au développement des métastases. Nous avons observé, in vitro, que la migration de trois lignées cancéreuses mammaires est augmentée par le peptide LL-37 et son énantiomère (D)-LL-37, excluant la fixation du peptide à un récepteur protéique. Sur les cellules cancéreuses mammaires MDA-MB-435s, le peptide se fixe à la membrane plasmique et diminue sa fluidité. La microscopie électronique localise LL-37 dans les cavéoles et à la surfac
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25

Habes, Chahrazed. "Stimulation du signal calcique et de la migration des cellules cancéreuses mammaires par le peptide LL-37 : un mécanisme d’attachement membranaire impliquant les glycosaminoglycanes et les syndécanes." Thesis, Tours, 2019. http://www.theses.fr/2019TOUR3807.

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Le peptide LL-37, peptide antimicrobien de l’immunité innée, est associé au développement tumoral. Sur des lignées cancéreuses mammaires. Il augmente le calcium intracellulaire et la migration. via l’activation de la voie PI3K/AKT et de canaux calciques. L’énantiomère (D)-LL-37 induit des effets similaires, excluant une interaction classique ligand-récepteur. Avec sa structure en hélice α amphipathique et sa charge nette +6, l’hypothèse était que le peptide utilise les charges négatives de glycanes sulfatés ou sialylés pour sa fixation membranaire avant d’induire ses activités. Des lectines vé
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Dannehl, Claudia [Verfasser], and Gerald [Akademischer Betreuer] Brezesinski. "Fragments of the human antimicrobial LL-37 and their interaction with model membranes / Claudia Dannehl. Betreuer: Gerald Brezesinski." Potsdam : Universitätsbibliothek der Universität Potsdam, 2013. http://d-nb.info/104363312X/34.

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Evers, Daniela [Verfasser], and Ursula [Akademischer Betreuer] Bilitewski. "Der Einfluss des antimikrobiellen Peptides LL-37 auf Candida albicans und den Infektionsprozess in vitro / Daniela Evers ; Betreuer: Ursula Bilitewski." Braunschweig : Technische Universität Braunschweig, 2012. http://d-nb.info/117589091X/34.

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Schwab, Julia [Verfasser], and W. [Gutachter] Scheppach. "Antimikrobielle Aktivität humaner Kolonepithelzellen gegenüber E. coli Nissle unter besonderer Berücksichtigung des Cathelicidins LL-37 / Julia Schwab. Gutachter: W. Scheppach." Würzburg : Universität Würzburg, 2014. http://d-nb.info/1102828556/34.

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29

Xhindoli, Daniela. "Insights into structural features that affect the biological activities and mode of action of the human antimicrobial cathelicidin LL-37." Doctoral thesis, Università degli studi di Trieste, 2014. http://hdl.handle.net/10077/10381.

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2012/2013<br>The human peptide LL-37 is an important innate immune effector that contributes to defending the organism against infection in different scenarios, ranging from direct bacterial killing to the modulation of immune responses and acting as a signal molecule for different cell types involved in defence or healing. All these functions are possible despite its relatively simple structure, due to its capacity to interact with different types of biological membranes. This cationic peptide is able to switch from a random coil in aqueous solutions into an amphipathic helical structure in p
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30

Vandewalle-Capo, Marine. "Étude de la sensibilité aux antibiotiques et aux peptides antimicrobiens humains de Legionella pneumophila." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1291/document.

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Legionella pneumophila (Lp) est un pathogène accidentel de l'homme capable d'infecter les macrophages alvéolaires et les pneumocytes. Au cours de l'infection, Legionella se confronte à différents types d'agents antibactériens, dont les peptides antimicrobiens (PAMs) produit par l'hôte et les antibiotiques à activité intracellulaire administrés aux patients. Le mécanisme d'action des PAMs humains à l'encontre de Legionella, ainsi que le niveau de résistance aux antibiotiques de la bactérie sont à ce jour encore peu documentés. Mes travaux ont pour but de contribuer à une meilleure connaissance
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31

McQuade, Rebecca. "Clostridium difficile Responds to Antimicrobial Peptides and Oxidative Stress." Diss., The University of Arizona, 2015. http://hdl.handle.net/10150/578613.

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Clostridium difficile (CD) is the leading cause of bacterial hospital-associated infection in North America. How CD colonizes the human host, including its response to the innate immune system and other stresses, is poorly understood. This work considers CD's defenses against two stresses found in the host - the antimicrobial peptide LL-37 and reactive oxygen species (ROS). LL-37 had bactericidal activity against CD. CD strains varied in their sensitivity to the peptide, and epidemic-associated strains were more resistant to LL-37 than others. CD became more resistant to LL-37 following exposu
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32

Bedran, Telma Blanca Lombardo [UNESP]. "Efeito antimicrobiano e modulador da resposta imune dos peptídeos hBD-3 e LL-37 e dos polifenóis o chá verde e do cranberry." Universidade Estadual Paulista (UNESP), 2014. http://hdl.handle.net/11449/124090.

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Made available in DSpace on 2015-06-17T19:34:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-03-14. Added 1 bitstream(s) on 2015-06-18T12:47:03Z : No. of bitstreams: 1 000830081_20160101.pdf: 121876 bytes, checksum: 342f21a15b1d2e738af168b1e2467da5 (MD5) Bitstreams deleted on 2016-01-04T10:26:29Z: 000830081_20160101.pdf,. Added 1 bitstream(s) on 2016-01-04T10:28:25Z : No. of bitstreams: 1 000830081.pdf: 809941 bytes, checksum: ea53cd5ef0cec7fb993a2745e82dad53 (MD5)<br>The antimicrobial peptides LL-37, hBD-1, hBD-2 and hBD-3 are considered an endogenous antibiotic, with important r
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Collins, Declan. "Factors predicting patient outcomes in a UK Burn's Unit : the influence of Acinetobacter baumannii and the antimicrobial peptide LL-37 in burn wounds." Thesis, Queen Mary, University of London, 2011. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8716.

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Sepsis and multi-organ failure are the most frequently reported causes of death in burn injuries. Their early identification allows therapies and resources to be targeted in a more effective and efficient way. Due to its frequent antibiotic drug resistance Acinetobacter baumannii (MRAB) is increasingly causing a problem in burns units. New strategies need to be found to combat infection and sepsis in the burn ICU. This study examines the potential of the Albumin Creatinine Ratio, a marker of systemic endothelial dysfunction in predicting outcomes, sepsis and multi-organ failure; the role of Ac
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Bedran, Telma Blanca Lombardo. "Efeito antimicrobiano e modulador da resposta imune dos peptídeos hBD-3 e LL-37 e dos polifenóis o chá verde e do cranberry /." Araraquara, 2014. http://hdl.handle.net/11449/124090.

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Orientador: Denise Madalena Palomari Spolidório<br>Banca:Juliana Rico Pires<br>Banca: Shelon Cristina Souza Pinto<br>Banca: Luciene Cristina Souza Pinto<br>Banca: Joni Augusto Cirelli<br>Resumo:Os peptídeos antimicrobianos como por exemplo a catelicina (LL-37) e as defensinas humanas (hBD-1, hBD-2 e a hBD-3) são considerados antibióticos endógenos com importante papel na prevenção das doenças periodontais, devido a sua capacidade de regulação da resposta imune, sendo que os mesmos podem ser degradados pelos periodontopatógenos. Terapias que aumentem a produção destes peptídeos pelas próprias c
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Malhotra, Sankalp. "Immune evasion tactics and immunopathology of mixed mucoid and nonmucoid Pseudomonas aeruginosa populations in cystic fibrosis." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1524156292309518.

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36

Thienhaus, Maike Luisa [Verfasser]. "Die Rolle der antimikrobiellen Peptide humanes beta-Defensin 3 (hBD-3) und LL-37 bei chronisch polypöser Rhinosinusitis und nasaler Besiedelung mit Staphylococcus aureus / Maike Luisa Thienhaus." Kiel : Universitätsbibliothek Kiel, 2014. http://d-nb.info/1046563300/34.

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37

Bociek, Karol. "Use of Tn5-transposon mutagenesis for the identification of potential novel interactors of antimicrobial peptides in E.coli." Doctoral thesis, Università degli studi di Trieste, 2010. http://hdl.handle.net/10077/3619.

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2008/2009<br>Antimicrobial peptides (AMPs) participate in the immunity of both animals and plants. In mammals, the most important AMP families are defensins and cathelicidins. The only human cathelicidin, LL-37, is a 37-residue, α-helical, cationic peptide with a direct membranolytic antibacterial activity and various immunomodulatory activities. The aim of our research was to establish a procedure based on an E. coli knock-out mutant library in the search for mutations conferring altered susceptibility to AMPs. The library was created by random insertions of Tn5 transposon into the bacterial
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38

Lofton, Tomenius Hava. "Mechanisms and Biological Costs of Bacterial Resistance to Antimicrobial Peptides." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-284119.

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The global increasing problem of antibiotic resistance necessarily drives the pursuit and discovery of new antimicrobial agents. Antimicrobial peptides (AMPs) initially seemed like promising new drug candidates. Already members of the innate immune system, it was assumed that they would be bioactive and non-toxic. Their common trait for fundamental, non-specific mode of action also seemed likely to reduce resistance development. In this thesis, we demonstrate the ease with which two species of pathogenic bacteria, the gram-negative Salmonella typhimurium (S. typhimurium), and the gram-positive
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KO, Yen-Chieh, and 葛彥頡. "Production of recombinant LL-37 and preparing SAW-MIP Biosensor for detection of LL-37." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/70840641425718170863.

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碩士<br>大同大學<br>生物工程學系(所)<br>98<br>It’s well known that bacteria have ability to develop antibiotic-resistance in short time after treatment. To find therapeutic agents with different mode of action than conventional antibiotics is a necessity. To meet the above requirement, antimicrobial peptides (AMPs) represent a good alternative for infective antibiotics. AMP LL-37 with positive charges belongs to an immune system that has a capacity to distinguish membrane composed by different lipids in human. This unique property enables LL-37 to destroy the negative charged bacteria membranes. In consequ
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40

Cheng, An-Ting, and 鄭安婷. "Interaction of LL-37 with Model Membrane Systems and Preparing Lipid Based Biosensor for the Detection of LL-37." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/76077186069867131972.

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碩士<br>大同大學<br>生物工程學系(所)<br>97<br>It’s well known that bacteria have ability to develop antibiotic-resistance in short time after treatment. To find therapeutic agents with different mode of action than conventional antibiotics is a necessity. To meet the above requirement, antimicrobial peptides (AMPs) represent a good alternative for infective antibiotics. AMP LL-37 with positive charges belongs to an immune system that has a capacity to distinguish membrane from different lipids in human. This special property makes LL-37 destroy the negative charged bacteria membranes. Therefore the above m
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41

Bowdish, Dawn Marie Edith. "LL-37, a human host defense peptide with immunomodulatory properties." Thesis, 2005. http://hdl.handle.net/2429/17332.

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Human cationic antimicrobial protein-18 (hCAP-18) is the sole human cathelicidin. It is found at high concentrations in the specific granules of neutrophils, is modestly expressed by epithelial and other cells and can be induced during the course of infection and/or inflammation. The mature, extracellular form of hCAP-18 is termed LL-37, which is a positively-charged, 37-amino acid peptide. Neutrophil-derived host defence peptides were initially discovered as components of the non-oxidative killing mechanisms of neutrophils; however, it is unclear whether LL-37 kills bacteria directly at mucos
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42

Lee, Jia-yi, and 李佳怡. "Functionalized interdigitated electrodes for sensing LL-37 using impedimetric measurement." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/91636841693677247539.

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碩士<br>大同大學<br>生物工程學系(所)<br>98<br>The secretion of positively charged antimicrobial peptides, AMP LL-37, is an innate defense mechanism in human and mouse when their urinary tracts are infected by bacteria. They can interact and destroy the negatively charged bacteria membranes, and are ignorant of any possible bacterial resistance derived from drug treatments. Thus LL-37 is considered a good marker of urinary tract infections. We design an interdigitated type sensing electrode on a printed-circuit board (PCB) to measure the electrical characteristics associated with the change of LL-37 concent
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43

KAMAKSHI. "CONFORMATIONAL PROFILE ASSESSMENT OF CATHELICIDIN (LL-37) USING MOLECULAR DYNAMICS SIMULATION." Thesis, 2013. http://dspace.dtu.ac.in:8080/jspui/handle/repository/15782.

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Understanding biological function at molecular level involves studying the spontaneous folding patterns of peptides to unique and biologically-active three-dimensional structures. Peptides are highly flexible in nature and fold at fast rates hence require probing at nanosecond time scale. Bioactive conformational structures of folded peptides need to be well characterized before using them in computer-aided drug design. Molecular dynamics (MD) simulations provide detailed information on the fluctuations and their affect. Cathelicidins are a novel family of antimicrobial peptides (AMP) charact
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Doho, Gregory Hyojun. "Global computational regulatory analysis of the anti-endotoxin effect of LL-37." Thesis, 2006. http://hdl.handle.net/2429/17651.

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LL-37, a human cationic peptide, selectively modulates the innate immune response by interacting with the effector cells of innate immunity. It has been demonstrated to stimulate chemokine production and protect against infection, as well as suppress the endotoxin/lipopolysaccharide (LPS)-mediated production of pro-inflammatory cytokines and endotoxic shock in mouse model experiments. Microarray experiments under these conditions have indicated that the expression of numerous genes is altered in the presence of LL-37 and/or LPS, but the mechanisms underlying these transcriptional changes and t
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45

Tsai, Pei-Wen, and 蔡裴雯. "Molecular Mechanisms of Human Antimicrobial Peptide LL-37 Inhibiting Candida albicans Adhesion." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/25975125409956462305.

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46

Strack, Christina Elisabeth. "Modulation der Genexpression des antimikrobiellen Peptids LL-37 in Abhängigkeit von exogenen Faktoren." Doctoral thesis, 2009. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-38956.

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In ständigem Kontakt mit zahlreichen Mikroorganismen benötigt unser Körper eine Vielzahl an Mechanismen zur Abwehr krankheitserregender Keime. Antimikrobielle Peptide unterstützen als Effektormoleküle die einzellige Epithelschicht des Darms, die als Mukosabarriere unseren Körper vor dem Eindringen pathogener Keime bewahrt. Die Expression des antimikrobiellen Peptids LL-37, auch Cathelicidin genannt, stellt eine Strategie des angeborenen Immunsystems zur Abwehr von Mikroorganismen im Kolon dar. Die Expression des Cathelicidin Gens camp kann, wie in der vorliegenden Arbeit untersucht wurde, durc
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47

Wong, Alicia. "Citrullination of LL-37 as a mechanism that selectively controls immunostimulatory potential of DNA." Praca doktorska, 2019. https://ruj.uj.edu.pl/xmlui/handle/item/73404.

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LL-37, jedyna ludzka katelicydyna, jest amfipatycznym, kationowym peptydem bakteriobójczym, który zawiera 37 reszt aminokwasowych. Dojrzały peptyd uwalniany jest z 18 kDa białka prekursorowego (katelicydyny) przez proteazę-3 w neutrofilach lub przez proteazy serynowe z rodziny kallikrein w keratynocytach. Oprócz zdolności bezpośredniego zabijania mikroorganizmów, LL-37 pełni funkcję immunomodulacyjną. Jedną z nich jest tworzenie kompleksów z ujemnie naładowanymi oligonukleotydami pochodzącymi zarówno z obumierających komórek gospodarza, jak i patogenów. Interakcja ta ułatwia rozpoznawanie DNA
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Lau, Yee-Lar Elaine. "Characterizing the interactions between the host defence peptide, LL-37, and lung epithelial cells." Thesis, 2004. http://hdl.handle.net/2429/15607.

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LL-37 is a human cationic host defense peptide that is a component of innate immunity. In addition to its modest antimicrobial activity, LL-37 affects the behavior of effector cells involved in the innate immune response, including modification of transcriptional responses. However, its mode of interaction with eukaryotic cells remains unclear. In this research study, the interaction of LL-37 with epithelial cells was characterized in tissue culture by using biotinylated LL-37 (LL-37B) and confocal microscopy. LL-37 was actively taken up into A549 human epithelial cells and eventually localize
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49

Chen, Yun-Ju, and 陳韻茹. "Study of Molecular Mechanisms of Candida albicans Response to Human Antimicrobial Peptide LL-37." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/50441681136576470916.

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碩士<br>國立清華大學<br>分子與細胞生物研究所<br>97<br>Candida albicans is one of the most important fungal pathogens in humans. C. albicans is a commensal in healthy individuals and can become invasive and pathogenic in the immunocompromised patients. LL-37 is a human cationic antimicrobial peptide that has been reported to exert its antifungal activity against C. albicans. Membrane-disruptive effects of LL-37 have been well investigated. However, several studies indicated that membrane disruption may not reflect the complex processes involved in the killing of microorganisms by LL-37. The main goal of this stu
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50

陳正益. "Studying the mode of action of human antimicrobial peptide LL-37 on Acinetobacter baumannii." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/06836331108733189876.

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碩士<br>國立清華大學<br>分子與細胞生物研究所<br>102<br>Acinetobacter baumannii is a Gram-negative coccobacillus and is a leading nosocomial pathogen worldwide. Recently, emergence of multidrug resistant A. baumannii has become a great threat to healthcare. Strains resist to the last line of anti-mocrobial agents, tigecycline and colistin, were appeared. Therefore, developing new drugs to treat A. baumannii infections is urgently needed. In this work, a human antimicrobial peptide LL-37 was evaluated for its effects on A. baumannii. We found that LL-37 kills A. baumannii efficiently and reduces cell adhesion and
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