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Artículos de revistas sobre el tema "Meiji Shoin"

Autor: Grafiati

Publicado: 27 de julio de 2024

Última modificación: 31 de julio de 2025

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1

Matsumoto, Kazuaki. "Yokoyama Shinichiro: The Hakuen Shoin and the Meiji Restoration—Policy-makers and Industrialists." Journal of Cultural Interaction in East Asia 12, no. 1 (2021): 63–68. http://dx.doi.org/10.1515/jciea-2021-2003.

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2

Levis, Brooke, Andrea Benedetti, Kira E. Riehm, et al. "Probability of major depression diagnostic classification using semi-structured versus fully structured diagnostic interviews." British Journal of Psychiatry 212, no. 6 (2018): 377–85. http://dx.doi.org/10.1192/bjp.2018.54.

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BackgroundDifferent diagnostic interviews are used as reference standards for major depression classification in research. Semi-structured interviews involve clinical judgement, whereas fully structured interviews are completely scripted. The Mini International Neuropsychiatric Interview (MINI), a brief fully structured interview, is also sometimes used. It is not known whether interview method is associated with probability of major depression classification.AimsTo evaluate the association between interview method and odds of major depression classification, controlling for depressive symptom

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3

Cohn, J. "Bungaku ni okeru “mukōgawa” [The “Other Side” in Literature]. Edited by Kokubungaku Kenkyū Shiryōkan (National Institute of Japanese Literature). Tokyo: Meiji Shoin, 1985. 295 pp. Notes. ¥2,800." Journal of Asian Studies 45, no. 4 (1986): 847–49. http://dx.doi.org/10.2307/2056112.

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4

Yoshihiko, Minamizawa. "Academic Trends in Japan’s Private Academies of Chinese Learning and Education in Modern Japan: With a Focus on Fujisawa Nangaku and Ishihama Juntaro of the Hakuen Academy." Institute of Korean Cultural Studies Yeungnam University 84 (August 31, 2023): 161–84. http://dx.doi.org/10.15186/ikc.2023.8.31.06.

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Japan’s modernization, which began with the Meiji Restoration in 1868, was modelled on the Western powers, and its modernization was virtually synonymous with Westernization. However, the situation was slightly different in the case of education. The education measures of the Meiji government were not fixed, and while it aimed for Westernization with respect to the education system, it vacillated between centralized standardization and laissez-faire principles. With regard to the content of education, too, it did not necessarily completely adhere to the modern education of the West, which was

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5

Clarke, Ted. "Multimode Trans-Illuminator for the Stereomicroscope." Microscopy Today 15, no. 4 (2007): 40–43. http://dx.doi.org/10.1017/s1551929500055711.

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The stereomicroscope was the main tool I once used for metallurgical failure analysis. I have owned a Meiji EMT Greenough-type stereomicroscope since the late 1980's. I had not used transmitted light with the stereomicroscope until about a year ago when I completed a multimode transmitted light illuminator for my Meiji stereomicroscope. I thought this capability would be very useful for introducing the grandkids to the microscopic world, especially with live lake water organisms. My earlier article in Microscopy Today, “Rediscovery of Darkfield Dispersion Staining while Building a Universal St

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6

Yang, Ji-sun. "Shin Chae-ho's Theory of Solidarity Between the Oppressed Ethnicities in the East." Bukak History Academy 16 (July 30, 2022): 57–82. http://dx.doi.org/10.37288/bukak.2022.16.3.57.

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The theory of interstate solidarity emerged in Japan. In Japan, the theory of Asian solidarity emerged in the wake of the Meiji Restoration. Influenced by Japan's theory of Asian solidarity, Sun Wen began to advocate Asianism in earnest in the 1920s. Shin Chae-ho is also one of the intellectuals influenced by the theory of social evolution. However, he tried to overcome the limitations of Asian solidarity theory with his logic. Through the experience of the March 1st Movement, he directly confirmed the power of the people and tried to escape the theory of social evolution developme

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7

Nami Park. "The Feminism Transmission shown at the Woman's Novel in the age of Meiji. -Focus on Higuchi Ichiyo's『Warekara』-." Journal of Japanese Studies ll, no. 42 (2009): 223–35. http://dx.doi.org/10.15733/jast.2009..42.223.

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8

YOSHIDA, Koichi. "WHO IS "SENJI MIZUTANI", A LEADING OPPONENT TO THE CONSERVATION WORKS OF SHIN-YAKUSHIJI TEMPLE IN THE MEIJI PERIOD?" Journal of Architecture and Planning (Transactions of AIJ) 72, no. 620 (2007): 229–34. http://dx.doi.org/10.3130/aija.72.229_3.

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9

Meijsing, Monica. "Hoe dik is het ik?" Algemeen Nederlands Tijdschrift voor Wijsbegeerte 111, no. 3 (2019): 311–38. http://dx.doi.org/10.5117/antw2019.3.002.meij.

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Abstract How fat is the I? Neuroscience and the elusive selfThis article explores the concept of self in relation to neuroscience. Four options are discussed on the basis of a key representative. The first is the dualist position where the non-material self controls its brain, as defended by Eccles. Next comes the option of the self as a relatively or completely powerless entity within the brain, as exemplified by Libet’s experiments on free will. The third option is the identity of self and brain, as argued by Dennett. The last option is the identity of self and body, and here Gallagher is th

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10

Waterhouse, David B., and Carl De Crée. "Shin-gi-tai as a guiding principle in Kodokan judo. Yet, another example of historical reinvention?" Revista de Artes Marciales Asiáticas 20, no. 1 (2025): 55–76. https://doi.org/10.18002/rama.v20i1.2504.

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Judo national governing bodies in recent years through slogans, posters, cartoons, and web site information have attempted to reignite their members’ appreciation for a judo morality constructed on Japanese bushido. Similarly, several judo federations actively promote ‘shin-gi-tai’ (mind-technique-body) as a guiding principle for rank promotions and conduct allegedly in association with Kano Jigoro’s philosophy. Using translation, critical and heuristic analysis of relevant original historical Japanese sources, it is the purpose of this paper to investigate the origin, etymology and justificat

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11

Homei, Aya. "Tempos modernos, novos partos e novas parteiras: o parto no Japão de 1868 aos Anos 1930." Revista Estudos Feministas 10, no. 2 (2002): 429–40. http://dx.doi.org/10.1590/s0104-026x2002000200012.

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As shin-sanba, ou 'novas parteiras' medicalizadas, que apareceram durante o período Meiji (1868-1912) no Japão, parecem ter, aos olhos atuais, substituído rapidamente e sem conflito as 'velhas parteiras' (kyû-sanba) e as cada vez mais criminalizadas 'parteiras não licenciadas' (mumenkyo-sanba), enquanto a profissão de parteira foi se desenvolvendo progressivamente como profissão médica moderna. Este artigo sugere que a história das parteiras na era moderna foi mais complexa do que aquilo que se imagina atualmente. Primeiro, o surgimento e a prosperidade das shin-sanba estiveram intrinsecamente

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12

Jung, Hwa Yol. "Ernest Fenollosa's Etymosinology in the Age of Global Communication." Theory, Culture & Society 26, no. 2-3 (2009): 249–73. http://dx.doi.org/10.1177/0263276409103129.

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This article puts forward the thesis that in the age of multiculturalism, global communication is rooted in cross-cultural understanding as shown in McLuhan's late communication theory. The American philosopher Ernest Fenollosa went to Japan during the Meiji Restoration when it started in earnest full-scale Westernization. He became fascinated with the poetics of sinography manifested in etymosinology. Etymosinology reveals the depth of the Sinic cultural soul, which is this-worldly, practical, concrete and specific. Sinism (i.e. Confucianism, Daoism and Chan/Zen Buddhism) is a species of rela

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13

YASUNO, Akira. "FORMATION OF MANAGEMENT POLICY OF ^|^apos;TAKARAZUKA SHIN-ONSEN^|^apos; -AMUSEMENT PARK WITH HOT SPRING BATHFROM THE END OF MEIJI TO EARLY SHOWA ERA." Journal of Architecture and Planning (Transactions of AIJ) 79, no. 702 (2014): 1809–17. http://dx.doi.org/10.3130/aija.79.1809.

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14

Eom, Seogin. "Motoda Nagazane’s standards of Confucianism – between Confucianism and Emperor Centralism." F1000Research 10 (May 7, 2021): 272. http://dx.doi.org/10.12688/f1000research.51001.2.

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This paper discusses the ideological significance of the activities of Motoda Nagazane who, in the latter half of his life, became an attendant of Emperor Meiji as a member of the Kumamoto school of practical science. Whilst there were trends towards modernisation and Westernisation, Motoda Nagazane led a conservative reaction attempting to restore Confucianist politics/policies. I scrutinise the theories of revolution and lineage considering the history of East Asian Confucianism and comparing Motoda’s assertions to the views expressed by Kumazawa Banzan. In doing so, I assert that Motoda’s c

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15

Eom, Seogin. "Motoda Nagazane’s standards of Confucianism – between Confucianism and Emperor Centralism." F1000Research 10 (April 6, 2021): 272. http://dx.doi.org/10.12688/f1000research.51001.1.

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This paper discusses the ideological significance of the activities of Motoda Nagazane who, in the latter half of his life, became an attendant of Emperor Meiji as a member of the Kumamoto school of practical science. Whilst there were trends towards modernisation and Westernisation, Motoda Nagazane led a conservative reaction attempting to restore Confucianist politics/policies. I scrutinise the theories of revolution and lineage considering the history of East Asian Confucianism and comparing Motoda’s assertions to the views expressed by Kumazawa Banzan. In doing so, I assert that Motoda’s c

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16

Целуйко, Дмитрий Сергеевич. "Основные направления архитектуры Японии периода Мэйдзи и Тайшо (конец XIX – начало XX вв.)". Вестник Инженерной школы ДВФУ, № 1(58) (29 березня 2024): 136–46. http://dx.doi.org/10.24866/2227-6858/2024-1/136-146.

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The article examines the main directions of Japanese architecture during the Meiji and Taisho periods. It was during these periods that the formation of the architectural communities of the empire took place, influencing the architecture of the entire Asia-Pacific region in the 20th and 21st centuries. The prerequisites for the formation of the Japanese giyefu style, based on a combination of Western and traditional architecture, and the invitation of a large number of foreign advisers to the country are shown. The text describes the four most important advisor personalities and their major ac

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17

Yoshioka, Hiroshi. "After “Cool Japan”: A Study on Cultural Nationalism." Culture and Dialogue 3, no. 2 (2015): 3–11. http://dx.doi.org/10.1163/24683949-00302003.

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What is the meaning of “Japanese” culture? In earlier ages, it was about temples, Noh plays, Kabuki, Utamaro and Wabi-sabi. These traditional icons have, since the Meiji era (1868-1912), been identified as typically Japanese. Are they, however, still relevant today? Has there been any crucial mutation in the cultural identity of Japan? In the contemporary era, more and more people associate Japanese culture with Manga, animation and video games, in other words with cultural developments of the post-World War II era. The Japanese Government has actively promoted the popularity of these new aspe

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18

Leitner, Bernhard. "For Body, Mind and the Nation: An Archaeology of Modern Japanese Psychiatry." Vienna Journal of East Asian Studies 5, no. 1 (2014): 111–38. http://dx.doi.org/10.2478/vjeas-2014-0005.

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Abstract This paper reassesses the history of psychiatry in Japan through application of the theory of disciplinary power by Michel Foucault. The society of the early Meiji era (1868-1912) is defined as a disciplinary society within the scope of discourses on punishment and general social reforms. By focussing on a close reading of both canonical and marginalised fragments of psychiatric texts, this analysis reveals their constitutive character for the establishment of psychiatric discourses. These texts, rooted in biological psychiatry, are shown to stress the hazard that mental illness prese

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19

Skvortsova, Elena L. "Traditional Motives in the Aesthetic Views of the 20th Century Japanese PhilosophersKuki Shuzo, Karaki Junzo, Kato Shinro." Voprosy Filosofii, no. 2 (2021): 175–86. http://dx.doi.org/10.21146/0042-8744-2021-2-175-186.

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The article is devoted to the views of three Japanese philosophers of the 20th century with their example we are convinced the relevance of the traditional worldview in contemporary Japan. Since the Meiji period, Western philosophy and aesthetic theories have constantly influenced the views of Japanese thinkers, but up to this day, traditionalism plays an important role in Japanese thought. This also applies to the emphasis on corporality, human incarnation – the Buddhist position on “the unity of flesh and mind” (shin-jin – itchinyo) and the uncertainty fluidity of all forms of existence o

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20

Bell, David. "A new vision: modern Japanese prints from the Heriot collection." Tuhinga 31 (June 1, 2020): 91–112. https://doi.org/10.3897/tuhinga.31.e34257.

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This is the third article addressing the 2016 Museum of New Zealand Te Papa Tongarewa (Te Papa) acquisition of a selection of Japanese artworks from the collection of Ian and Mary Heriot. Its scope embraces woodblock prints from the Meiji, Taishö and Shöwa periods (1868–1912, 1912–26, and 1926–89, respectively). These include compositions relatively unfamiliar in New Zealand; most earlier collectors had been preoccupied with the ukiyo-e ‘floating world pictures’ of the eighteenth and nineteenth centuries.The works are significant, however, for appreciating the twentieth-century revitalisation

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21

Trung, Do Duc, Branislav Dudić, Duong Van Duc, Nguyen Hoai Son, and Aleksandar Ašonja. "Comparison of MCDM methods effectiveness in the selection of plastic injection molding machines." Teknomekanik 7, no. 1 (2024): 1–19. http://dx.doi.org/10.24036/teknomekanik.v7i1.29272.

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In each specific problem of finding the best solution among many available options, where each option has multiple criteria, multi criteria decision making methods are considered equally effective when they converge to the same optimal solution. Proximity Indexed Value, Preference Selection Index, Faire Un Choix Adéquat (in French), and Collaborative Unbiased Rank List Integration are four Multi Criteria Decision Making methods with very different characteristics. All these four methods have been used a lot in recent times. The effectiveness of these four methods have been confirmed to be comp

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22

Phillipps, Jeremy. "Living on Past Glories and Future Dreams The Effects of Depopulation on Early Modern Urban Development in the Former Castle Town of Kanazawa." European Journal of East Asian Studies 7, no. 2 (2008): 263–94. http://dx.doi.org/10.1163/156805808x372449.

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AbstractDepopulation of urban areas is a serious issue in twenty-first century Japan, as shown by the recent large-scale amalgamation of municipalities and programmes to combat declining central city areas. However, this is not the first time depopulation has had a significant effect on urban development: the decline in castle towns after the Meiji Restoration of 1868 had profound effects on both urban form and development concepts. Kanazawa, once one of the largest cities in Japan, suffered from an initial and long-lasting drop and then a more insidious decline as its Japan Sea coast location

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23

Pozzi, Carlo Edoardo. "A Political Consideration on the Japan-Italy TreatyRevision Relations During the Inoue Kaoru Foreign Affairs Era (1879-1887) Centering on Japanese and Italian Primary Sources." Analele Universității de Vest. Seria Științe Filologice 60, no. 1 (2023): 25–43. http://dx.doi.org/10.35923/autfil.60-1.03.

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In the early Meiji Era, the revision of the so-called “Unequal Treaties” was an issue of vital importance to the Japanese government. In particular, since the early 1880s Foreign Minister Inoue Kaoru (1836-1915), unlike his predecessor Terashima Munenori (1832-1893), who had given priority to the acquisition of tariff autonomy, sought to include in the negotiations with foreign powers also the abolition of extraterritoriality. In this context, the Kingdom of Italy found itself playing a significant role in Inoue’s foreign policy in the 1870s after the Italian diplomats in Tokyo had shown a str

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24

Semenov, Oleg Yu. "GERMAN-JAPANESE BILATERAL RELATIONS GENESIS IN THE SECOND HALF OF THE 19TH CENTURY." RSUH/RGGU Bulletin. Series Political Sciences. History. International Relations 4, no. 3 (2023): 423–33. http://dx.doi.org/10.28995/2073-6339-2023-4-423-433.

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The paper provides a retrospective historical overview of forming and developing bilateral relations between Germany and Japan in the second half of the 19th century on the basis of documents and materials, previously largely not introduced into Russian scientific discourse. Taking as an example the commemorative events marking the 160th anniversary of the f irst diplomatic treaty, the relevance of the research subject which allows a clearer logic and features understanding of the modern dialogue between the two countries. The prerequisites and historical conditions for the interaction genesis

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25

Akhmylovskaya, Larisa Alekseevna. "The 2023-2024 museum programs dedicated to the works of Japanese female artists of the Meiji, Taishō and Shōwa eras." Manuscript 17, no. 2 (2024): 58–69. http://dx.doi.org/10.30853/mns20240009.

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The aim of the research is to identify the features of the structure and content of a series of museum programs dedicated to the activities of outstanding Japanese female visual artists, as reflected in the exhibitions of 2023-2024. The author focuses on portrait painting presented in these exhibitions. The paper discusses the results of analyzing materials from research programs primarily focused on painting during the Meiji, Taishō and Shōwa periods. Studying academic publications, interviews, and catalogs of international museum events related to the works of innovative Japanese female arti

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26

Looft-Wilson, R. C., R. D. Matthes, and C. V. Gisolfi. "Heat acclimation does not alter rat mesenteric artery response to norepinephrine." Journal of Applied Physiology 86, no. 2 (1999): 536–40. http://dx.doi.org/10.1152/jappl.1999.86.2.536.

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Previous studies have shown that heat acclimation raises the temperature threshold for heat-induced splanchnic vasoconstriction in the rat (W. Haddad and M. Horowitz. Thermal Balance in Health and Disease, Advances in Pharmacological Sciences. Basel: Birkhauser, 1994, p. 203–208; M. Shochina, W. Haddad, U. Meiri, and M. Horo-witz. J. Therm. Biol. 21: 289–295, 1996). We tested the hypothesis that heat acclimation alters splanchnic resistance artery sensitivity to norepinephrine (NE). Male Sprague-Dawley rats ( n = 5) were acclimated to 35°C ambient temperature for 5–8 wk. Control rats ( n = 5)

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27

Sandi, Rizal Rahma, Dieta Wahyu Asry Ningtias, and Heri Yudiono. "Analysis of Micro Structure, Porosity Disability and Wear Resistance with Volume Variation from Riser On the Engine Cover of Electric Motors." Journal of Electronics Technology Exploration 1, no. 2 (2023): 77–86. http://dx.doi.org/10.52465/joetex.v1i2.282.

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This research to analyze the microstructure, porosity defects, and wear resistance of aluminum casting in the presence of variations in the volume of risers. The method used is the pre-experimental method of the One-Shot Case Study type, because in this study a treatment will be carried out and the results will be observed. The treatment that will be carried out is the addition of variations not using risers, variations of riser cylinders with a volume of 2826mm3, variations of riser cylinders with a volume of 4710mm3, variations of riser cylinders with a volume of 6594mm3. Microstructure test

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28

Zvyagina, E. Yu, N. N. Ogarkov, M. A. Polyakova, and M. D. Sukhova. "Estimation of depth and degree of mill roll surface hardening during grit texturing." Izvestiya. Ferrous Metallurgy 63, no. 9 (2020): 735–41. http://dx.doi.org/10.17073/0368-0797-2020-9-735-741.

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The paper presents shot blasting (SB) as the most common method of arrangement of temper mills rolls surface microgeometry, providing required roughness of the cold-rolled strip. The surface riffing studies were carried out at the Willibrator industrial unit; metallographic studies were performed using MEIJI 2700 optical microscope and JSM-6490LV scanning electron microscope. Refinement of the surface layer structure during interaction of the roll material with the grit was revealed. In the work the lower bound method, one of the methods of plasticity theory, is used for theoretical analysis o

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Satrya HD, Dharma, and Baiq Rismarini Nursaly. "Back to Java: The discourse of Lombok art in Salman Faris�s Kenari Mentaram." EduLite: Journal of English Education, Literature and Culture 6, no. 1 (2021): 179. http://dx.doi.org/10.30659/e.6.1.179-188.

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This article is triggered by the emergence of ethnicity aspects in Indonesian literature. The importance of ethnicity in Indonesian literature is because Indonesian literature is assumed to be plural, not singular. That is, the reality of Indonesia in Indonesian literature is not limited to one ethnicity, but various ethnicities. In the perspective of modern Indonesian literature, Indonesian novels are synonymous with Malay, Jakarta, Java and several other cities that have contributed to the development of Indonesian literature. In the perspective of ethnic Indonesian literature, Indonesian no

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Takahashi, Hiromichi, Sumiko Kobayashi, Katsuhiro Miura, et al. "Clinical Significance of Co-Expression of MYC and BCL2 Protein in Advanced Diffuse Large B-Cell Lymphoma Treated with a Dose-Intensified Immunochemotherapy." Blood 126, no. 23 (2015): 3940. http://dx.doi.org/10.1182/blood.v126.23.3940.3940.

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Abstract Background Recent studies have shown that the concurrent expression of MYC and BCL2 protein evaluated by immunohistochemistry (IHC) in patients with de novo diffuse large B-cell lymphoma (DLBCL) is associated with worse survival when treated with standard R-CHOP, but the effect of intensive chemotherapies for such patients is unknown. Thus, we evaluated the impact of the co-expression of MYC and BCL2 protein among patients with advanced DLBCL, who were treated with a dose-intensive immunochemotherapy followed by up-front autologous stem cell transplantation (ASCT). Patients and Method

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Coates, L., B. Strober, J. Yu, et al. "POS1538 SAFETY OF GUSELKUMAB ACROSS DIVERSE PATIENT SUBGROUPS WITH PSORIATIC DISEASE: AN INTEGRATED ANALYSIS OF 11 PHASE 2/3 CLINICAL STUDIES IN PSORIASIS AND PSORIATIC ARTHRITIS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1134–35. http://dx.doi.org/10.1136/annrheumdis-2023-eular.1917.

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BackgroundA higher prevalence of comorbidities, such as obesity, prior treatments, and certain demographics (e.g., age and sex) in patients (pts) with psoriatic disease (PsD) may lead to an increased risk of adverse events (AEs), sometimes serious[1]. Guselkumab (GUS), a fully human, selective IL-23p19-subunit inhibitor approved to treat (tx) adults with active psoriatic arthritis (PsA) and moderate to severe plaque psoriasis (PsO), has shown a favorable safety profile consistent between PsA and PsO pts through up to 2 and 5 years (yrs) of follow-up in the pooled PsA and PsO trials, respective

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MIYAZAKI, Nobuyuki, and Masao AOKI. "ON THE TRIALS SHOWN IN THE IDEAS OF PLANNING METHOD FOR IMPROVING ON THE HYGIENIC ASPECT OF DWELLING HOUSE BY TEXTBOOKS FOR HOME ECONOMICS IN JAPAN IN MEIJI 20'S PERIOD : Historical studies on the planning method of house from a viewpoint of hygiene Part 2." Journal of Architecture and Planning (Transactions of AIJ) 60, no. 467 (1995): 61–70. http://dx.doi.org/10.3130/aija.60.61_1.

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Trzciński, Grzegorz. "Bearing Capacity of Forest Roads on Poor-Bearing Road Subgrades following Six Years of Use." Forests 13, no. 11 (2022): 1888. http://dx.doi.org/10.3390/f13111888.

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The research was conducted on a forest road on the territory of the State Forests in Poland, in the Brzeziny Forest District, where eight test sections with a total length of 422 m were created with different pavement system on a low-bearing soil substrate (clay, silt loam) as part of the road reconstruction in 2016. The bearing capacity of the pavement was evaluated based on the static strain modulus ME MN·m−2 by measuring with a statistic plate (VSS), the dynamic deformation modulus Evd MN·m−2 obtained from lightweight deflectometer measurements, and the elastic deflection of the pavement Us

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Pinto, Jorge. "Chinese Teachers' Attitudes Towards Translanguaging and its Uses in Portuguese Foreign Language Classrooms." Theory and Practice of Second Language Acquisition 6, no. 1 (2020): 11–30. https://doi.org/10.31261/tapsla.7742.

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Recent research has shown that L1 use can serve important cognitive, communicative, and social functions in communicative foreign and second language learning (Turnbull & Dailey-O’Cain, 2009). In the context of Chinese universities, Meij and Zhao (2010) argue that is widespread agreement among administrators that the L1 should not be used in L2 classrooms. Both teachers and students should follow this norm. However, in their study, they found that translanguaging practice is perceived by teachers and students as a useful approach to achieve desired learning outcomes. Other studies (Cai &am

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Mease, P. J., A. Setty, K. Papp, et al. "POS1041 LONG-TERM EFFICACY AND SAFETY OF UPADACITINIB IN PATIENTS WITH PSORIATIC ARTHRITIS REFRACTORY TO BIOLOGIC THERAPIES: 2-YEAR RESULTS FROM THE PHASE 3 SELECT-PsA 2 STUDY." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 836–37. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1897.

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BackgroundUpadacitinib (UPA), an oral Janus kinase (JAK) inhibitor, demonstrated efficacy and safety in patients (pts) with psoriatic arthritis (PsA) and prior inadequate response or intolerance to ≥1 biologic disease-modifying antirheumatic drug (bDMARD) at week (wk) 56 in the phase 3 SELECT-PsA 2 study.1ObjectivesTo evaluate the efficacy and safety of UPA at wk 104 from the ongoing long-term extension of SELECT-PsA 2.MethodsPts were randomized to UPA 15 mg (UPA15), UPA 30 mg (UPA30), or placebo (PBO) for 24 wks; PBO pts were then switched to UPA15 or UPA30. For continuous UPA treatment group

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Ivanova, I. B. "Verb Constructions Expressing the Functional-Semantic Concept HUMAN AGE in the Yakut Language." NSU Vestnik. Series: Linguistics and Intercultural Communication 20, no. 3 (2022): 39–50. http://dx.doi.org/10.25205/1818-7935-2022-20-3-39-50.

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The article presents the results of a morpho-syntactic analysis of the most common verb constructions denoting the functional-semantic concept ʻhuman ageʼ in the Yakut language. The subject matter of the study is set expressions in Yakut containing verbs and participles. The relevance of the study is due to the lack of knowledge about the functionalsemantic concept PERSON’S AGE in Yakut linguistics. Scientific novelty of the study is in paying special attention not only to morphological forms and grammatical features, but also to semantics. It was shown that in expressing the functional-semant

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NGUYEN, Hoang Chinh, Kuan-Hung LIN, Meng-Yuan HUANG, et al. "Antioxidant Activities of the Methanol Extracts of Various Parts of Phalaenopsis Orchids with White, Yellow, and Purple Flowers." Notulae Botanicae Horti Agrobotanici Cluj-Napoca 46, no. 2 (2018): 457–65. http://dx.doi.org/10.15835/nbha46211038.

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Phalaenopsis (Phal.) orchids including white, yellow, and purple flowers are some of the most important commercial orchids worldwide. These flowering plants can be considered to be promising sources of antioxidants since several medicinal orchids were shown to have potential antioxidant activities. The antioxidant activities and several secondary metabolite compounds of the methanolic extracts of four parts (the root, pedicel, leaf, and flower) of three hybrids of white (Phal. ‘City More’), yellow (Phal. ‘Sogo Meili’), and purple (Phal. ‘Queen Beer’) flowering orchids were investigated. Result

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Shipilova, M. A. "Concept <i>Japanese National Character</i> through the Prism of Migration Policy." Concept: philosophy, religion, culture 6, no. 1 (2022): 107–24. http://dx.doi.org/10.24833/2541-8831-2022-1-21-107-124.

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The strategy and tactics of Japan's contemporary migration policy are determined by the ethnocultural characteristics of the Japanese nation, recognized as the concept of national character (国民性 kokuminsei), which is both a political and scientific entity. The rapid changes in migration policy today expose the practical need to study the causes, consequences, and specifics of related social and political concepts such as national character and the factors that shape it. The accurate knowledge helps predict cultural, political, and socioeconomic changes and future agendas. This concept is a sub

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Tretyakova, Maria S., and Nadezhda S. Philonenko. "IKEBANA OF 20TH CENTURY: AESTHETICS OF OHARA SCHOOL AND SOGETSU SCHOOL." Vestnik Tomskogo gosudarstvennogo universiteta. Kul'turologiya i iskusstvovedenie, no. 55 (2024): 200–213. https://doi.org/10.17223/22220836/55/16.

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Although the art of ikebana has spread in Russia in the 1960s, the aesthetics of ikebana rarely becomes the subject of scientific reflection in our country. The aim of this study is to analyze the aesthetic basics of the two main modern schools of ikebana, Ohara and Sogetsu, and find out the difference between them. In the study we raise the problems of modern ikebana and accordingly turn to the idea of ‘living form’ in traditional Chinese and Japanese flower arrangement. The basics of the aesthetics of the Ohara school were laid in the Meiji era (1868–1912), when European flowers began to be

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Hu, Yonghan, Dongdong Wu, Wei Peng, et al. "Abstract 3090: Discovery of XNW9015, a potent, selective, and CNS-penetrating covalent inhibitor of CDK7 with excellent in vivo antitumor activities." Cancer Research 83, no. 7_Supplement (2023): 3090. http://dx.doi.org/10.1158/1538-7445.am2023-3090.

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Abstract Cyclin-dependent kinase 7 (CDK7) is an upstream regulator of CDKs and serve as a component of the CDK-activated kinase (CAK) along with cyclin H and MAT1, which regulates cell cycle progression by phosphorylation of cell cycle CDKs.. CAK is also a component of transcription factor TFIIH. CDK7 can phosphorylate RNA polymerase II at active gene promoters to permit transcription. Because of its dual role in transcription and cell cycle progression, and elevated expression level in various cancer types and association with their clinical outcomes, CDK7 inhibition could be an attractive th

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Kihara, Yoshihiko, Marito Araki, Misa Imai, et al. "Therapeutic Potential of an Antibody Targeting the Cleaved Form of Mutant Calreticulin in Myeloproliferative Neoplasms." Blood 136, Supplement 1 (2020): 9–10. http://dx.doi.org/10.1182/blood-2020-141159.

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Mutant calreticulin (CALR) has been shown to play a causal role in the development of essential thrombocythemia (ET) and primary myelofibrosis (PMF) via activation of the thrombopoietin receptor MPL. The oncogenic property of mutant CALR originates from a +1 frameshift mutation in its carboxyl-terminal domain, which is found in approximately 30% of patients with ET and PMF. Because the domain is uniquely found in mutant CALR, it has been recognized as a neoantigen and can therefore be used to target CALR-mutant cells using immunotherapy. In the present study, we found that a large portion of t

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Camacho Encina, M., V. Balboa-Barreiro, I. Rego-Perez, et al. "FRI0387 A PROGNOSTIC MODEL OF PRE-RADIOGRAPHIC KNEE OSTEOARTHRITIS: DATA FROM THE OSTEOARTHRITIS INITIATIVE." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 791.2–791. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4450.

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Background:The improvement of the existing diagnostic methods to detect pre-radiographic knee OA (KOA) may facilitate the development of preventive strategies. It has been postulated that combining biochemical with clinical markers, may increase the prognostic power to detect who is at high risk for developing KOA.Objectives:To validate and qualify the ability of 6 proteins with biomarker potential to generate a prognostic model of knee OA prediction through the combination of validated OA biomarkers and clinical markers.Methods:In thevalidation phase(Figure 1), 749 sera at the baseline visit

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Mashima, Kiyomi, Kazuya Sato, Norihito Takayama, et al. "Dimethyl Fumarate Ameliorates Graft-Versus-Host Disease By Negatively Regulating Aerobic Glycolysis in Alloreactive T-Cells." Blood 136, Supplement 1 (2020): 24–25. http://dx.doi.org/10.1182/blood-2020-136229.

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Background Dimethyl fumarate (DMF), a fumaric acid derivative, is currently used worldwide as a therapeutic agent for autoimmune diseases, such as multiple sclerosis and psoriasis. As an activator of Nrf-2, DMF protects cells from oxidative stress by inducing anti-oxidant enzymes. In addition, a recent report in Science has shown that DMF catalytically inactivates GAPDH, thereby reduces glycolytic activity, and results in immune modulation in activated CD4+ T-cells. We have previously shown that DMF and its metabolite monomethyl fumarate (MMF) significantly inhibit 3H-thymidine uptake in activ

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Hu, Yonghan, Xin Li, Bin Huang, et al. "Abstract A071: XNW14010:A highly selective KRASG12C inhibitor with potent efficacy in animal model of pancreatic cancer." Cancer Research 82, no. 22_Supplement (2022): A071. http://dx.doi.org/10.1158/1538-7445.panca22-a071.

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Abstract KRAS mutations are frequently found in various types of cancers with an overall mutation frequency of 19.3%. G12C mutation of KRAS (KRASG12C) represents 11.4% of all KRAS mutations in cancer. Targeting KRAS mutations as a cancer treatment strategy has long been investigated for over 30 years already but still remains unconquered field. XNW14010 is a highly selective KRASG12C inhibitor that is rationally designed from AMG510, another proven covalent inhibitor of KRASG12C with potential antineoplastic activity. Compared to AMG510, XNW14010 demonstrated a better pharmaceutical potential

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Sánchez-Pedreira, P. C., Á. Vela-Anero, N. Otero Queijas, et al. "THU0061 EVALUATION OF SAFETY AND EVOLUTION OF OSTEOARTHRITIC JOINTS AFTER THE ADMINISTRATION OF HETEROLOGOUS MESENCHYMAL STROMAL CELLS IN AN ANIMAL MODEL." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 242.2–243. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4795.

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Background:One of the main osteoarthritis (OA) consequences is the cartilage loss. Nowadays there is not cure for the OA, so there is an intense research focused on finding a therapy to solve this problem. In this paradigm heterologous mesenchymal stromal cells (MSCH) rise as a solution. Different studies used them as a cellular therapy in order to regenerate damaged cartilage. Furthermore, MSCH have shown anti-inflammatory effects.Objectives:1) Study the safety of a single intraarticular injection of MSCH derived from healthy canine fat tissue (adMSCH) in OA joints of dogs2) Observe the evolu

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Inano, Tadaaki, Marito Araki, Soji Morishita, et al. "Concomitant Occurrence of Polyclonal Hematopoiesis and Cell-Autonomous Megakaryopoiesis in Triple-Negative Essential Thrombocythemia." Blood 136, Supplement 1 (2020): 27–28. http://dx.doi.org/10.1182/blood-2020-134494.

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Somatic mutations in JAK2, MPL, and CALR are found in approximately 80% of patients with essential thrombocythemia (ET), whereas the remaining patients are negative for disease-defining mutations and are defined as triple-negative (TN). Studies have shown that some patients with TN-ET harbor non-canonical mutations in JAK2 and MPL; however, the failure to identify recurrent mutations in most patients has made the pathogenesis of TN-ET ambiguous (Milosevic Feenstra et al. Blood 2016, Cabagnols et al. Blood 2016). In this study, we screened 483 patients suspected as having ET in a single center,

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Tian, Meijie, Adam Cheuk, David Milewski, et al. "Abstract 552: FGFR4 and CD276 dualtargeting CAR-T cells for treating rhabdomyosarcoma and other solid tumors." Cancer Research 82, no. 12_Supplement (2022): 552. http://dx.doi.org/10.1158/1538-7445.am2022-552.

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Abstract Background: Chimeric antigen receptor T-cell therapies (CAR-T) have shown success in treating refractory and relapsed leukemia and lymphoma, while they perform poorly in solid tumors due to heterogenous expression of tumor-associated antigens (TAAs), limited T cell persistence and propensity for exhaustion. The receptor tyrosine kinase FGFR4 and immune checkpoint molecule CD276 are highly and heterogeneously expressed in some solid tumors, including Rhabdomyosarcoma (RMS), a most common soft tissue sarcoma of childhood, and human hepatocellular carcinoma (HCC). However, their expressi

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Gong, Jifang, Lei Chen, Meili Sun, et al. "Abstract CT542: Preliminary safety and efficacy results of KN046 in combination with KN026 in patients with locally advanced unresectable or metastatic HER2-positive solid cancer." Cancer Research 82, no. 12_Supplement (2022): CT542. http://dx.doi.org/10.1158/1538-7445.am2022-ct542.

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Abstract Except breast cancer and gastric cancer, HER2 gene amplification or overexpression is also expressed in other solid tumors, including but not limited to colorectal cancer (CRC), non-small cell lung cancer (NSCLC), gallbladder cancer, renal pelvis cancer and pancreatic cancer. The reports of immunotherapy combined with HER2-targeted therapy are limited. KN046 is a novel bispecific antibody that blocks both PD-L1 interaction with PD-1 and CTLA4 interaction with CD80/CD86. KN026 is a novel bispecific antibody that simultaneously binds to two distinct HER2 epitopes. Here the preliminary s

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Tian, Meijie, Jun S. Wei, Adam Cheuk, et al. "Abstract 1784: FGFR4 and CD276 dual targeting CAR T cells demonstrate synergistic antitumor activity in childhood rhabdomyosarcoma." Cancer Research 83, no. 7_Supplement (2023): 1784. http://dx.doi.org/10.1158/1538-7445.am2023-1784.

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Abstract Background Chimeric antigen receptor T cells (CAR T) are potential therapies for rhabdosarcoma (RMS), the most common soft tissue sarcoma in children, where patients with relapsed or refractory disease have a dismal cure rate, and effective therapies are urgently needed. RMS tumors express high levels of the cell surface receptors FGFR4 and CD276, and both are direct targets of the PAX3-FOXO1 chimeric oncogene. However, CAR T have shown poor performance in solid tumors due to T cell exhaustion, limited persistence, and heterogeneous expression of target antigens. We hypothesize that e

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Tanimoto, Kazuki, Koji Kato, Takatoshi Aoki, et al. "CHOP Plus Sequential Mogamulizumab As First-Line Therapy for Untreated Adult T-Cell Leukemia-Lymphoma." Blood 138, Supplement 1 (2021): 1393. http://dx.doi.org/10.1182/blood-2021-151937.

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Abstract Introduction: Adult T-cell leukemia/lymphoma (ATL) is an aggressive peripheral T-cell lymphoma caused by human T-cell lymphotropic virus type I. In younger patients, allogeneic hematopoietic stem cell transplantation (HSCT) has been shown to improve prognosis through a graft-versus-ATL (GvATL) effect. On the other hand, elderly patients with ATL are often not amenable to HSCT, and the prognosis is extremely poor with existing chemotherapy. The most widely used chemotherapy for ATL, CHOP (combination of cyclophosphamide-doxorubicin-vincristine-prednisone) and similar chemotherapy, have

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