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1

Murshed, Monzur, Neil Smyth, Nicolai Miosge, Jörg Karolat, Thomas Krieg, Mats Paulsson, and Roswitha Nischt. "The Absence of Nidogen 1 Does Not Affect Murine Basement Membrane Formation." Molecular and Cellular Biology 20, no. 18 (September 15, 2000): 7007–12. http://dx.doi.org/10.1128/mcb.20.18.7007-7012.2000.

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ABSTRACT Nidogen 1 is a highly conserved protein in mammals,Drosophila melanogaster, Caenorhabditis elegans, and ascidians and is found in all basement membranes. It has been proposed that nidogen 1 connects the laminin and collagen IV networks, so stabilizing the basement membrane, and integrates other proteins, including perlecan, into the basement membrane. To define the role of nidogen 1 in basement membranes in vivo, we produced a null mutation of the NID-1 gene in embryonic stem cells and used these to derive mouse lines. Homozygous animals produce neither nidogen 1 mRNA nor protein. Sur
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2

Hagedorn, Elliott J., Joshua W. Ziel, Meghan A. Morrissey, Lara M. Linden, Zheng Wang, Qiuyi Chi, Sam A. Johnson, and David R. Sherwood. "The netrin receptor DCC focuses invadopodia-driven basement membrane transmigration in vivo." Journal of Cell Biology 201, no. 6 (June 10, 2013): 903–13. http://dx.doi.org/10.1083/jcb.201301091.

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Though critical to normal development and cancer metastasis, how cells traverse basement membranes is poorly understood. A central impediment has been the challenge of visualizing invasive cell interactions with basement membrane in vivo. By developing live-cell imaging methods to follow anchor cell (AC) invasion in Caenorhabditis elegans, we identify F-actin–based invadopodia that breach basement membrane. When an invadopodium penetrates basement membrane, it rapidly transitions into a stable invasive process that expands the breach and crosses into the vulval tissue. We find that the netrin
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3

Nazari, Shayan S., Andrew D. Doyle, and Kenneth M. Yamada. "Mechanisms of Basement Membrane Micro-Perforation during Cancer Cell Invasion into a 3D Collagen Gel." Gels 8, no. 9 (September 7, 2022): 567. http://dx.doi.org/10.3390/gels8090567.

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Cancer invasion through basement membranes represents the initial step of tumor dissemination and metastasis. However, little is known about how human cancer cells breach basement membranes. Here, we used a three-dimensional in vitro invasion model consisting of cancer spheroids encapsulated by a basement membrane and embedded in 3D collagen gels to visualize the early events of cancer invasion by confocal microscopy and live-cell imaging. Human breast cancer cells generated large numbers of basement membrane perforations, or holes, of varying sizes that expanded over time during cell invasion
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4

LAURIE, G. W., and C. P. LEBLOND. "Basement membrane nomenclature." Nature 313, no. 6000 (January 1985): 272. http://dx.doi.org/10.1038/313272b0.

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5

Weber, Manfred. "Basement membrane proteins." Kidney International 41, no. 3 (March 1992): 620–28. http://dx.doi.org/10.1038/ki.1992.95.

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6

Gunwar, Sripad, Fernando Ballester, Milton E. Noelken, Yoshikazu Sado, Yoshifumi Ninomiya, and Billy G. Hudson. "Glomerular Basement Membrane." Journal of Biological Chemistry 273, no. 15 (April 10, 1998): 8767–75. http://dx.doi.org/10.1074/jbc.273.15.8767.

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7

Ray, Marilyn C., and Leonard E. Gately. "Basement membrane zone." Clinics in Dermatology 14, no. 4 (July 1996): 321–30. http://dx.doi.org/10.1016/0738-081x(96)00061-2.

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8

Li, A. C. Y. "Basement membrane components." Journal of Clinical Pathology 56, no. 12 (December 1, 2003): 885–87. http://dx.doi.org/10.1136/jcp.56.12.885.

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9

Eady, Robin A. J. "The Basement Membrane." Archives of Dermatology 124, no. 5 (May 1, 1988): 709. http://dx.doi.org/10.1001/archderm.1988.01670050053021.

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10

Bosman, Fred T., Jack Cleutjens, Cor Beek, and Michael Havenith. "Basement membrane heterogeneity." Histochemical Journal 21, no. 11 (November 1989): 629–33. http://dx.doi.org/10.1007/bf01002481.

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11

Desjardins, M., and M. Bendayan. "Ontogenesis of glomerular basement membrane: structural and functional properties." Journal of Cell Biology 113, no. 3 (May 1, 1991): 689–700. http://dx.doi.org/10.1083/jcb.113.3.689.

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Protein A-gold immunocytochemistry was applied in combination with morphometrical approaches to reveal the alpha 1(IV), alpha 2(IV), and alpha 3(IV) chains of type IV collagen as well as entactin on renal basement membranes, particularly on the glomerular one, during maturation. The results have indicated that a heterogeneity between renal basement membranes appears during the maturation process. In the glomerulus at the capillary loop stage, both the epithelial and endothelial cell basement membranes were labeled for the alpha 1(IV) and alpha 2(IV) chains of type IV collagen and entactin. Aft
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12

Nishi, S., M. Ueno, R. Karasawa, S. Kawashima, H. In, H. Hayashi, N. Saito, et al. "Morphometric study of glomerular basement membrane and proximal tubular basement membrane in adult thin basement membrane disease." Clinical and Experimental Nephrology 3, no. 4 (December 20, 1999): 290–95. http://dx.doi.org/10.1007/s101570050049.

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13

Pastor-Pareja, José C. "Atypical basement membranes and basement membrane diversity – what is normal anyway?" Journal of Cell Science 133, no. 8 (April 15, 2020): jcs241794. http://dx.doi.org/10.1242/jcs.241794.

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14

Bader, Bernhard L., Neil Smyth, Sabine Nedbal, Nicolai Miosge, Anke Baranowsky, Sharada Mokkapati, Monzur Murshed, and Roswitha Nischt. "Compound Genetic Ablation of Nidogen 1 and 2 Causes Basement Membrane Defects and Perinatal Lethality in Mice." Molecular and Cellular Biology 25, no. 15 (August 1, 2005): 6846–56. http://dx.doi.org/10.1128/mcb.25.15.6846-6856.2005.

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ABSTRACT Nidogen 1 and 2 are basement membrane glycoproteins, and previous biochemical and functional studies indicate that they may play a crucial role in basement membrane assembly. While they show a divergent expression pattern in certain adult tissues, both have a similar distribution during development. Gene knockout studies in mice demonstrated that the loss of either isoform has no effect on basement membrane formation and organ development, suggesting complementary functions. Here, we show that this is indeed the case. Deficiency of both nidogens in mice resulted in perinatal lethality
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15

McCarthy, K. J., K. Bynum, P. L. St John, D. R. Abrahamson, and J. R. Couchman. "Basement membrane proteoglycans in glomerular morphogenesis: chondroitin sulfate proteoglycan is temporally and spatially restricted during development." Journal of Histochemistry & Cytochemistry 41, no. 3 (March 1993): 401–14. http://dx.doi.org/10.1177/41.3.8429203.

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We previously reported the presence of a basement membrane-specific chondroitin sulfate proteoglycan (BM-CSPG) in basement membranes of almost all adult tissues. However, an exception to this ubiquitous distribution was found in the kidney, where BM-CSPG was absent from the glomerular capillary basement membrane (GBM) but present in other basement membranes of the nephron, including collecting ducts, tubules, Bowman's capsule, and the glomerular mesangium. In light of this unique pattern of distribution and of the complex histoarchitectural reorganization occurring during nephrogenesis, the pr
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16

Ball, E. E., H. G. de Couet, P. L. Horn, and J. M. Quinn. "Haemocytes secrete basement membrane components in embryonic locusts." Development 99, no. 2 (February 1, 1987): 255–59. http://dx.doi.org/10.1242/dev.99.2.255.

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Several monoclonal antibodies raised against a glycoprotein-enriched fraction of adult muscle membranes of Locusta migratoria selectively stain particles within haemocytes and basement membrane in developing locust embryos. Haemocytes containing immunoreactive particles are found associated with areas where basement membrane is being laid down. The underlying ectoderm does not show immunoreactivity. We conclude that haemocytes contribute to basement membrane formation in embryonic locusts.
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17

Boyd, RB, JP Burke, J. Atkin, VW Thompson, and JF Nugent. "Significance of capillary basement membrane changes in diabetes mellitus." Journal of the American Podiatric Medical Association 80, no. 6 (June 1, 1990): 307–13. http://dx.doi.org/10.7547/87507315-80-6-307.

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Diabetes mellitus is a disease in which the capillary basement membranes are substantially altered. This diabetic microangiopathy is characterized by a thickening of the basement membrane and changes in its permeability characteristic due to a disturbance in the production and distribution of its functional components. Glucose metabolism and insulin imbalance have been implicated in these basement membrane modifications. The authors describe normal capillary basement membrane architecture and then discuss how pathologic changes caused by diabetes mellitus are related to diabetic foot pathology
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18

Schymeinsky, Jürgen, Sabine Nedbal, Nicolai Miosge, Ernst Pöschl, Cherie Rao, David R. Beier, William C. Skarnes, Rupert Timpl, and Bernhard L. Bader. "Gene Structure and Functional Analysis of the Mouse Nidogen-2 Gene: Nidogen-2 Is Not Essential for Basement Membrane Formation in Mice." Molecular and Cellular Biology 22, no. 19 (October 1, 2002): 6820–30. http://dx.doi.org/10.1128/mcb.22.19.6820-6830.2002.

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ABSTRACT Nidogens are highly conserved proteins in vertebrates and invertebrates and are found in almost all basement membranes. According to the classical hypothesis of basement membrane organization, nidogens connect the laminin and collagen IV networks, so stabilizing the basement membrane, and integrate other proteins. In mammals two nidogen proteins, nidogen-1 and nidogen-2, have been discovered. Nidogen-2 is typically enriched in endothelial basement membranes, whereas nidogen-1 shows broader localization in most basement membranes. Surprisingly, analysis of nidogen-1 gene knockout mice
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19

Jung, Chi Young, Sun-Jae Lee, Min-Kyung Kim, Dong Jik Ahn, and In Hee Lee. "Anti-glomerular basement membrane disease associated with thin basement membrane nephropathy." Medicine 100, no. 20 (May 21, 2021): e26095. http://dx.doi.org/10.1097/md.0000000000026095.

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20

Nguyen, Nguyet M., Yushi Bai, Katsumi Mochitate та Robert M. Senior. "Laminin α-chain expression and basement membrane formation by MLE-15 respiratory epithelial cells". American Journal of Physiology-Lung Cellular and Molecular Physiology 282, № 5 (1 травня 2002): L1004—L1011. http://dx.doi.org/10.1152/ajplung.00379.2001.

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Basement membranes have a critical role in alveolar structure and function. Alveolar type II cells make basement membrane constituents, including laminin, but relatively little is known about the production of basement membrane proteins by murine alveolar type II cells and a convenient system is not available to study basement membrane production by murine alveolar type II cells. To facilitate study of basement membrane production, with particular focus on laminin chains, we examined transformed murine distal respiratory epithelial cells (MLE-15), which have many structural and biochemical fea
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21

Pusey, Charles, and Stephen McAdoo. "Antiglomerular Basement Membrane Disease." Seminars in Respiratory and Critical Care Medicine 39, no. 04 (August 2018): 494–503. http://dx.doi.org/10.1055/s-0038-1669413.

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AbstractAntiglomerular basement membrane (anti-GBM) disease is a rare but life-threatening autoimmune vasculitis that is characterized by the development of pathogenic autoantibodies to type IV collagen antigens expressed in the glomerular and alveolar basement membranes. Once deposited in tissue, these autoantibodies incite a local capillaritis which manifests as rapidly progressive glomerulonephritis (GN) in 80 to 90% of patients, and with concurrent alveolar hemorrhage in ∼50%. A small proportion of cases may present with pulmonary disease in isolation. Serological testing for anti-GBM anti
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22

Borycki, Anne-Gaëlle. "The myotomal basement membrane." Cell Adhesion & Migration 7, no. 1 (January 2013): 72–81. http://dx.doi.org/10.4161/cam.23411.

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23

Tryggvason, Karl, and Jaakko Patrakka. "Thin Basement Membrane Nephropathy." Journal of the American Society of Nephrology 17, no. 3 (February 8, 2006): 813–22. http://dx.doi.org/10.1681/asn.2005070737.

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24

Kearney, Phillip A. "Epithelial basement membrane dystrophy." Clinical and Experimental Optometry 78, no. 6 (November 1995): 221–22. http://dx.doi.org/10.1111/j.1444-0938.1995.tb00827.x.

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25

Miner, Jeffrey H. "Renal basement membrane components." Kidney International 56, no. 6 (December 1999): 2016–24. http://dx.doi.org/10.1046/j.1523-1755.1999.00785.x.

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26

Yao, Yao. "Basement membrane and stroke." Journal of Cerebral Blood Flow & Metabolism 39, no. 1 (September 18, 2018): 3–19. http://dx.doi.org/10.1177/0271678x18801467.

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Located at the interface of the circulation system and the CNS, the basement membrane (BM) is well positioned to regulate blood–brain barrier (BBB) integrity. Given the important roles of BBB in the development and progression of various neurological disorders, the BM has been hypothesized to contribute to the pathogenesis of these diseases. After stroke, a cerebrovascular disease caused by rupture (hemorrhagic) or occlusion (ischemic) of cerebral blood vessels, the BM undergoes constant remodeling to modulate disease progression. Although an association between BM dissolution and stroke is ob
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27

Thompson, C. H., and S. Kalowski. "Anti-Glomerular Basement Membrane." Nephron 58, no. 2 (1991): 238–39. http://dx.doi.org/10.1159/000186424.

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28

Kahsai, Tesfamichael Z., George C. Enders, Sripad Gunwar, Charlott Brunmark, Jörgen Wieslander, Raghuram Kalluri, Jing Zhou, Milton E. Noelken, and Billy G. Hudson. "Seminiferous Tubule Basement Membrane." Journal of Biological Chemistry 272, no. 27 (July 4, 1997): 17023–32. http://dx.doi.org/10.1074/jbc.272.27.17023.

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29

Labbé, Antoine, Raphaël De Nicola, Bénédicte Dupas, François Auclin, and Christophe Baudouin. "Epithelial Basement Membrane Dystrophy." Ophthalmology 113, no. 8 (August 2006): 1301–8. http://dx.doi.org/10.1016/j.ophtha.2006.03.050.

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30

Miner, Jeffrey H. "The glomerular basement membrane." Experimental Cell Research 318, no. 9 (May 2012): 973–78. http://dx.doi.org/10.1016/j.yexcr.2012.02.031.

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31

KLEINMAN, HYNDA K., GORDON W. LAURIE, JOHN R. HASSELL, FRANCES B. CANNON, and VICKI L. STAR. "Basement Membrane Supramolecular Complexes." Annals of the New York Academy of Sciences 460, no. 1 Biology, Chem (December 1985): 463–65. http://dx.doi.org/10.1111/j.1749-6632.1985.tb51210.x.

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32

Savige, Judy, Kesha Rana, Stephen Tonna, Mark Buzza, Hayat Dagher, and Yan Yan Wang. "Thin basement membrane nephropathy." Kidney International 64, no. 4 (October 2003): 1169–78. http://dx.doi.org/10.1046/j.1523-1755.2003.00234.x.

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33

Yurchenco, Peter D. "Macromolecular organization of basement membrane laminin." Proceedings, annual meeting, Electron Microscopy Society of America 49 (August 1991): 176–77. http://dx.doi.org/10.1017/s0424820100085186.

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Laminin isoforms are major structural and cell-interacting components of basement membranes. The most extensively studied isoform of this glycoprotein (800 kDa) is murine EHS laminin which consists of three polypeptide chains (A,B1,B2) disulfide linked to form a flexible four-armed molecule which in turn is often complexed to entactin, a smaller dumbell-shaped sulfated glycoprotein. One of the functions proposed for laminin is selfassembly into a polymer that constitutes a major part of basement membrane architecture. The principal evidence for this hypothesis has derived from biochemical and
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34

Crary, Gretchen S., Avi Katz, Alfred J. Fish, Alfred F. Michael, and Ralph J. Butkowski. "Role of a basement membrane glycoprotein in anti-tubular basement membrane nephritis." Kidney International 43, no. 1 (January 1993): 140–46. http://dx.doi.org/10.1038/ki.1993.23.

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35

Singhal, Pooja, Kevin Yi Mi Ren, Bryan M. Curtis, Ian MacPherson, and Carmen Avila-Casado. "Atypical Noncrescentic Antiglomerular Basement Membrane Disease With Concurrent Thin Basement Membrane Nephropathy." Kidney International Reports 3, no. 4 (July 2018): 991–96. http://dx.doi.org/10.1016/j.ekir.2018.03.012.

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36

Miosge, Nicolai, Fabio Quondamatteo, Christina Klenczar, and Rainer Herken. "Nidogen-1: Expression and Ultrastructural Localization During the Onset of Mesoderm Formation in the Early Mouse Embryo." Journal of Histochemistry & Cytochemistry 48, no. 2 (February 2000): 229–37. http://dx.doi.org/10.1177/002215540004800208.

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Nidogen-1, a key component of basement membranes, is considered to function as a link between laminin and collagen Type IV networks and is expressed by mesenchymal cells during embryonic and fetal development. It is not clear which cells produce nidogen-1 in early developmental stages when no mesenchyme is present. We therefore localized nidogen-1 and its corresponding mRNA at the light and electron microscopic level in Day 7 mouse embryos during the onset of mesoderm formation by in situ hybridization, light microscopic immunostaining, and immunogold histochemistry. Nidogen-1 mRNA was found n
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37

Abrahamson, D. R. "Origin of the glomerular basement membrane visualized after in vivo labeling of laminin in newborn rat kidneys." Journal of Cell Biology 100, no. 6 (June 1, 1985): 1988–2000. http://dx.doi.org/10.1083/jcb.100.6.1988.

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To examine the origin and assembly of glomerular basement membranes (GBMs), affinity purified anti-laminin IgG was directly coupled to horseradish peroxidase (HRP) and intravenously injected into newborn rats. Kidneys were then processed for peroxidase histochemistry and microscopy. Within 1 h after injection, anti-laminin bound to basement membranes of nephrons in all developmental stages (vesicle, comma, S-shaped, developing capillary loop, and maturing glomeruli). In S-shaped and capillary loop glomeruli, anti-laminin-HRP labeled a double basal lamina between the endothelium and epithelium.
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38

Basset-Seguin, N., M. Dersookian, K. Cehrs, and K. B. Yancey. "C3d,g is present in normal human epidermal basement membrane." Journal of Immunology 141, no. 4 (August 15, 1988): 1273–80. http://dx.doi.org/10.4049/jimmunol.141.4.1273.

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Abstract mAb as well as polyclonal anti-human C3d antibodies were found to specifically bind to the epidermal basement membrane zone of normal human adult and neonatal skin in a linear continuous pattern on direct immunofluorescence microscopy. No such binding was found in dermal microvascular basement membranes. Studies of normal adult human skin using a rat mAb specific for C3g revealed the same pattern of epidermal basement membrane staining. Control polyclonal antibodies directed against C3, C3c, C5, IgG, IgA, or IgM showed no evidence of epidermal basement membrane binding or in situ depo
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39

EBIHARA, Isao, and Hikaru KOIDE. "Structure and function of glomerular basement membrane." membrane 14, no. 1 (1989): 2–10. http://dx.doi.org/10.5360/membrane.14.2.

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40

Schaumburg-Lever, G., I. Lever, B. Fehrenbacher, H. Möller, B. Bischof, and A. Blum. "Melanocytes in Nevi and melanomas synthesize basement membrane and basement membrane-like material." Journal of Dermatological Science 16 (March 1998): S105. http://dx.doi.org/10.1016/s0923-1811(98)83624-4.

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41

Bonsib, Stephen M. "The macula densa tubular basement membrane: A unique plaque of basement membrane specialization." Journal of Ultrastructure and Molecular Structure Research 97, no. 1-3 (October 1986): 103–8. http://dx.doi.org/10.1016/s0889-1605(86)80010-6.

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42

Trzebiatowska, Agnieszka, Ulrike Topf, Ursula Sauder, Krzysztof Drabikowski, and Ruth Chiquet-Ehrismann. "Caenorhabditis elegans Teneurin, ten-1, Is Required for Gonadal and Pharyngeal Basement Membrane Integrity and Acts Redundantly with Integrin ina-1 and Dystroglycan dgn-1." Molecular Biology of the Cell 19, no. 9 (September 2008): 3898–908. http://dx.doi.org/10.1091/mbc.e08-01-0028.

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The Caenorhabditis elegans teneurin ortholog, ten-1, plays an important role in gonad and pharynx development. We found that lack of TEN-1 does not affect germline proliferation but leads to local basement membrane deficiency and early gonad disruption. Teneurin is expressed in the somatic precursor cells of the gonad that appear to be crucial for gonad epithelialization and basement membrane integrity. Ten-1 null mutants also arrest as L1 larvae with malformed pharynges and disorganized pharyngeal basement membranes. The pleiotropic phenotype of ten-1 mutant worms is similar to defects found
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43

Stratman, Amber N., and George E. Davis. "Endothelial Cell-Pericyte Interactions Stimulate Basement Membrane Matrix Assembly: Influence on Vascular Tube Remodeling, Maturation, and Stabilization." Microscopy and Microanalysis 18, no. 1 (December 14, 2011): 68–80. http://dx.doi.org/10.1017/s1431927611012402.

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AbstractExtracellular matrix synthesis and deposition surrounding the developing vasculature are critical for vessel remodeling and maturation events. Although the basement membrane is an integral structure underlying endothelial cells (ECs), few studies, until recently, have been performed to understand its formation in this context. In this review article, we highlight new data demonstrating a corequirement for ECs and pericytes to properly deposit and assemble vascular basement membranes during morphogenic events. In EC only cultures or under conditions whereby pericyte recruitment is block
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44

Couchman, J. R. "Heterogeneous distribution of a basement membrane heparan sulfate proteoglycan in rat tissues." Journal of Cell Biology 105, no. 4 (October 1, 1987): 1901–16. http://dx.doi.org/10.1083/jcb.105.4.1901.

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A heparan sulfate proteoglycan (HSPG) synthesized by murine parietal yolk sac (PYS-2) cells has been characterized and purified from culture supernatants. A monospecific polyclonal antiserum was raised against it which showed activity against the HSPG core protein and basement membrane specificity in immunohistochemical studies on frozen tissue sections from many rat organs. However, there was no reactivity with some basement membranes, notably those of several smooth muscle types and cardiac muscle. In addition, it was found that pancreatic acinar basement membranes also lacked the HSPG type
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45

Grant, D. S., and C. P. Leblond. "Immunogold quantitation of laminin, type IV collagen, and heparan sulfate proteoglycan in a variety of basement membranes." Journal of Histochemistry & Cytochemistry 36, no. 3 (March 1988): 271–83. http://dx.doi.org/10.1177/36.3.2963856.

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A series of basement membranes was immunolabeled for laminin, type IV collagen, and heparan sulfate proteoglycan in the hope of comparing the content of these substances. The basement membranes, including thin ones (less than 0.3 micron) from kidney, colon, enamel organ, and vas deferens, and thick ones (greater than 2 micron), i.e., Reichert's membrane, Descemet's membrane, and EHS tumor matrix, were fixed in formaldehyde, embedded in Lowicryl, and treated with specific antisera or antibodies followed by anti-rabbit immunoglobulin bound to gold. The density of gold particles, expressed per mi
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46

Uobe, K., S. Wada, M. Wato, T. Nishikawa, A. Tanaka, K. Nishida, and M. Tsutsui. "Monoclonal Antibodies Against Gingival Components." Advances in Dental Research 2, no. 2 (November 1988): 240–44. http://dx.doi.org/10.1177/08959374880020020801.

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The aim of this study was to produce and characterize monoclonal antibodies against human gingival epithelial cells and gingival fibroblasts. By using these whole cells as immunogens, we were able to generate a large number of monoclonal antibodies reacting with tissue antigens, in particular antibodies that reacted with desmosomes (MoAbs 7 and 8) and basement membrane (MoAb FB-1) antigens. MoAbs 7 and 8 produced from epithelial cells stained cell membranes of epithelium and desmosomes, respectively, as shown by light and immunoelectron microscopy. The epitopes to which MoAbs 7 and 8 were reac
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47

Ueda, Hideho, Takashi Gohdo та Shinichi Ohno. "β-Dystroglycan Localization in the Photoreceptor and Müller cells in the Rat Retina Revealed by Immunoelectron Microscopy". Journal of Histochemistry & Cytochemistry 46, № 2 (лютий 1998): 185–91. http://dx.doi.org/10.1177/002215549804600207.

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β-Dystroglycan (β-DG) is a dystrophin-associated glycoprotein that is expressed in skeletal muscle and other tissues. In the retina, dystrophin is present in the outer plexiform layer (OPL), where it is enriched under the photoreceptor cell membrane. In this study we determined the immunocytochemical localization of β-DG at both light and electron microscopic levels. β-DG immunoreactivity was detected at the inner limiting membrane, OPL, and around blood vessels. Immunoelectron microscopy detected β-DG immunoreactive products under the photoreceptor cell membrane, which are the same regions of
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48

Leivo, I., and E. Engvall. "C3d fragment of complement interacts with laminin and binds to basement membranes of glomerulus and trophoblast." Journal of Cell Biology 103, no. 3 (September 1, 1986): 1091–100. http://dx.doi.org/10.1083/jcb.103.3.1091.

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Two mouse monoclonal antibodies generated against human placental homogenate were found to react specifically with human complement component C3. In immunofluorescence of human tissues, these antibodies gave a bright linear staining outlining the glomerular basement membrane of the adult kidney and the trophoblast basement membrane of placenta. An identical staining pattern was observed with a rabbit C3d antiserum which also prevented binding of the monoclonal antibodies to tissue sections. Only negligible basement membrane staining was observed in the same tissues with antisera to human C3c,
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49

Streuli, C. H., and M. J. Bissell. "Expression of extracellular matrix components is regulated by substratum." Journal of Cell Biology 110, no. 4 (April 1, 1990): 1405–15. http://dx.doi.org/10.1083/jcb.110.4.1405.

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Reconstituted basement membranes and extracellular matrices have been demonstrated to affect, positively and dramatically, the production of milk proteins in cultured mammary epithelial cells. Here we show that both the expression and the deposition of extracellular matrix components themselves are regulated by substratum. The steady-state levels of the laminin, type IV collagen, and fibronectin mRNAs in mammary epithelial cells cultured on plastic dishes and on type I collagen gels have been examined, as has the ability of these cells to synthesize, secrete, and deposit laminin and other, ext
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50

Murray, P., and D. Edgar. "Regulation of the differentiation and behaviour of extra-embryonic endodermal cells by basement membranes." Journal of Cell Science 114, no. 5 (March 1, 2001): 931–39. http://dx.doi.org/10.1242/jcs.114.5.931.

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Both the extracellular matrix and parathyroid hormone-related peptide (PTHrP) have been implicated in the differentiation and migration of extra-embryonic endodermal cells in the pre-implantation mammalian blastocyst. In order to define the individual roles and interactions between these factors in endodermal differentiation, we have used embryoid bodies derived from Lamc1(-/-) embryonic stem cells that lack basement membranes. The results show that in the absence of basement membranes, increased numbers of both visceral and parietal endodermal cells differentiate, but they fail to form organi
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