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Artículos de revistas sobre el tema "Metastases"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 26 de julio de 2025

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1

Chakari, Wahida, Luise Andersen, and Jørgen Lock Andersen. "Cutaneous Metastases from Salivary Duct Carcinoma of the Submandibular Gland." Case Reports in Dermatology 9, no. 3 (2017): 254–58. http://dx.doi.org/10.1159/000485371.

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Salivary duct carcinoma is a rare and highly aggressive malignant neoplasm that frequently metastasises to other organs, but cutaneous metastasis is uncommon. There are only 6 cases reported in the literature with metastases to the skin and in all cases the tumour originates from the parotid gland. We present a case of skin metastases from the submandibular gland that was mistaken for basal cell carcinoma. To the best of our knowledge, this is the first reported case of salivary duct carcinoma arising from the submandibular gland with cutaneous metastases.

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Al-Muqbel, Kusai M. "Bone Marrow Metastasis Is an Early Stage of Bone Metastasis in Breast Cancer Detected Clinically by F18-FDG-PET/CT Imaging." BioMed Research International 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/9852632.

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Objective. To determine the value of 18F-FDG PET/CT in detection of bone marrow (BM) metastasis in breast cancer which is considered an early stage of bone metastasis. Patients and Methods. Retrospectively, breast cancer patients with bone metastasis were included. BM metastasis was considered if the lesion was PET positive/CT occult while bone metastasis was considered if the lesion was PET positive/ CT positive. BM metastases were observed sequentially on F18-FDG PET/CT. Results. We included 35 patients. Eighteen patients (51%) had BM metastases in addition to other bone metastases. BM metas

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Adibi, Mehrad, Patrick Kenney, Arun Z. Thomas, Catherine E. Devine, Jose A. Karam, and Christopher G. Wood. "Predicting pulmonary metastases among patients with indeterminate pulmonary nodules with renal cell carcinoma." Journal of Clinical Oncology 33, no. 7_suppl (2015): 505. http://dx.doi.org/10.1200/jco.2015.33.7_suppl.505.

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505 Background: Indeterminate pulmonary nodules (IPN) are of uncertain significance in renal cell carcinoma (RCC) patients. We sought to determine the natural history of IPN in patients undergoing radical nephrectomy and to identify clinical variables associated with the development of lung metastases. Methods: We reviewed all radical nephrectomy patients at a single institution from 2005 – 2009 who had ≥1 IPN on chest computed tomography (CT) within 6 months prior to surgery and no evidence of distant metastates. All chest CTs were re-reviewed by a radiologist who was blinded to outcomes to i

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Karpathiou, Georgia, Florian Camy, Céline Chauleur, Maroa Dridi, Pierre Dal Col, and Michel Peoc’h. "Brain Metastases from Gynecologic Malignancies." Medicina 58, no. 4 (2022): 548. http://dx.doi.org/10.3390/medicina58040548.

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Background and Objectives: To present a series of brain metastases from gynecologic primaries and provide a summary of the relevant literature. Materials and Methods: We retrospectively review 18 patients with histologically confirmed brain metastases from gynecologic primaries and summarize the largest series of relative reports. Results: Six brain metastases were of endometrial primary and 12 of ovarian primary. In 3 cases (16.7%), diagnosis of brain metastases was made at presentation of the gynecologic primary; in the others, median time to development of brain metastasis was 34 (range, 6–

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Ahmed, Mohamed E., Jack R. Andrews, Ahmed Mahmoud, et al. "Survival patterns based on site-specific visceral metastasis in patients with metastatic prostate cancer: Are outcomes of visceral metastases the same?" Journal of Clinical Oncology 41, no. 6_suppl (2023): 269. http://dx.doi.org/10.1200/jco.2023.41.6_suppl.269.

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269 Background: Metastatic visceral involvement in prostate cancer patients conveys a poor prognosis. Survival patterns of site-specific visceral metastasis are poorly understood. Here, we sought to investigate survival patterns in prostate cancer patients according to their first detected site of visceral metastasis. Methods: Retrospectively, we identified 200 patients with visceral metastatic prostate cancer. Patients were divided into three groups according to first site detected with visceral metastases; first-site lung metastases, first-site brain metastases, and first-site liver metastas

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Ali, Kamran, Sukki Cho, Hyo Jun Jang, Kwhanmien Kim, and Sanghoon Jheon. "Predictive Factors of Thoracic Lymph Node Metastasis Accompanying Pulmonary Metastasis from Colorectal Cancer." Thoracic and Cardiovascular Surgeon 67, no. 08 (2018): 683–87. http://dx.doi.org/10.1055/s-0038-1642602.

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Background The aim of this study was to identify the factors predicting thoracic lymph node (LN) metastases for pulmonary resection from colorectal cancer (CRC). Methods The records of 160 patients who underwent pulmonary metastasectomy for CRC were retrospectively reviewed. Clinicopathologic factors were analyzed with chi-square test or t-test and logistic regression to identify predictable factors for LN metastases. Results Sixty patients (37.5%) underwent LN dissection during pulmonary metastasectomy, and LN metastases were found in five patients. Twenty-three patients had LN recurrence amo

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Shi, Tiantian, Long Wang, Zhisong Fan, et al. "Specific organ metastases and survival of advanced non-small cell lung cancer (NSCLC) patients with EGFR mutation." Journal of Clinical Oncology 38, no. 15_suppl (2020): e21527-e21527. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e21527.

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e21527 Background: The retrospective study was performed to evaluate the clinicopathological characteristics and survival associated with distant metastasis from advanced NSCLC with EGFR mutation. Methods: The records of metastasis NSCLC patients with EGFR mutation at the time of diagnosis between 2012 and 2018 were reviewed. The Kaplan-Meier method was used to assess survival curves and the log-rank test was used in the univariate analysis. The multivariate survival analysis were performed using the Cox proportional hazards model to investigate the effects of clinicopathological factors on su

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Serra, Estefania, Álvaro Abarzua-Araya, Ana Arance, et al. "Predictive and Prognostic Factors in Melanoma Central Nervous System Metastases—A Cohort Study." Cancers 16, no. 12 (2024): 2272. http://dx.doi.org/10.3390/cancers16122272.

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Background: Melanoma is the cancer with the highest risk of dissemination to the central nervous system (CNS), one of the leading causes of mortality from this cancer. Objective: To identify patients at higher risk of developing CNS metastases and to evaluate associated prognostic factors. Methods: A cohort study (1998–2023) assessed patients who developed CNS melanoma metastases. Multivariate logistic regression was used to identify predictive factors at melanoma diagnosis for CNS metastasis. Cox regression analysis evaluated the CNS-independent metastasis-related variables impacting survival

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Zegarac, Milan, Srdjan Nikolic, Igor Djurisic, and Marko Buta. "Surgical treatment of colorectal liver metastasis after neoadjuvant chemotherapy." Journal of Clinical Oncology 30, no. 4_suppl (2012): 688. http://dx.doi.org/10.1200/jco.2012.30.4_suppl.688.

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688 Background: Liver is typical place for metastasis for patients with colorectal carcinoma. During the period of disease, 50% of patients with colorectal carcinoma will get liver metastases, 20% of the will have synchronous and 30% metachronous. Surgical resection is modality of choice in treatment for liver metastases in colorectal carcinoma. Applying neoadjuvant chemotherapy in patients with colorectal cancer liver metastases, which are primarily nonresectable or potentially resectable, it is possible to transform in resectable state. The goal of treatment is R0 liver resection and putting

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Kaplieva, I. V., E. M. Frantsiyants, L. K. Trepitaki, N. D. Cheryarina, and Yu A. Pogorelova. "CHARACTERISTICS OF STEROID METABOLISM IN MALE RATS AT STAGES OF EXPERIMENTAL LIVER METASTASIS." Russian Journal of Oncology 22, no. 2 (2017): 93–100. http://dx.doi.org/10.18821/1028-9984-2017-22-2-93-100.

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The aim of the study was to reveal characteristics of steroid metabolism in tumor, metastases, adrenal glands (AG) and blood serum (BS) in male rats in the course of liver metastasis, as well as diagnostic signs of metastases. Material and methods. The study included 44 white male rats weighing 180-250 g. S-45 sarcoma was transplanted intrasplenically. Estrone, estradiol, free testosterone, 17-OHP, cholesterol, cortisol (in tissues and BS), DHEAS (in tissues), DHEA and ACTH (in BS) were studied by the using standard test kits for ELISA and RIA. Results. We found that the pituitary gland does n

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Isidro, Ulysses, Liam M. O'Brien, and Ronnie Sebro. "Linear mixed-effects models for estimation of pulmonary metastasis growth rate: implications for CT surveillance in patients with sarcoma." British Journal of Radiology 93, no. 1114 (2020): 20190856. http://dx.doi.org/10.1259/bjr.20190856.

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Objectives: Sarcoma patients often undergo surveillance chest CT for detection of pulmonary metastases. No data exist on the optimal surveillance interval for chest CT. The aim of this study was to estimate pulmonary metastasis growth rate in sarcoma patients. Methods: This was a retrospective review of 95 patients with pulmonary metastases (43 patients with histologically confirmed metastases and 52 with clinically diagnosed metastases) from sarcoma treated at an academic tertiary-care center between 01 January 2000 and 01 June 2019. Age, sex, primary tumor size, grade, subtype, size and volu

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Asano, Naofumi, Michiro Susa, Seiichi Hosaka, et al. "Metastatic Patterns of Myxoid/Round Cell Liposarcoma: A Review of a 25-Year Experience." Sarcoma 2012 (2012): 1–6. http://dx.doi.org/10.1155/2012/345161.

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Myxoid/round cell liposarcoma (MRCL), unlike other soft tissue sarcomas, has been associated with unusual pattern of metastasis to extrapulmonary sites. In an attempt to elucidate the clinical features of MRCL with metastatic lesions, 58 cases, from the medical database of Keio University Hospital were used for the evaluation. 47 patients (81%) had no metastases, whereas 11 patients (11%) had metastases during their clinical course. Among the 11 patients with metastatic lesions, 8 patients (73%) had extrapulmonary metastases and 3 patients (27%) had pulmonary metastases. Patients were further

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Ladegaard, Thea H., Michala S. Sørensen, and Michael M. Petersen. "Solitary versus multiple bone metastases in the appendicular skeleton." Bone & Joint Journal 105-B, no. 11 (2023): 1206–15. http://dx.doi.org/10.1302/0301-620x.105b11.bjj-2023-0378.r1.

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AimsWe first sought to compare survival for patients treated surgically for solitary and multiple metastases in the appendicular skeleton, and second, to explore the role of complete and incomplete resection (R0 and R1/R2) in patients with a solitary bony metastasis in the appendicular skeleton.MethodsWe conducted a retrospective study on a population-based cohort of all adult patients treated surgically for bony metastases of the appendicular skeleton between January 2014 and December 2019. We excluded patients in whom the status of bone metastases and resection margin was unknown. Patients w

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Miller, G., P. Biernacki, N. Kemeny, et al. "Outcomes after resection of synchronous or metachronous hepatic and pulmonary colorectal metastases." Journal of Clinical Oncology 25, no. 18_suppl (2007): 4059. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.4059.

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4059 Background: Surgical resection of isolated hepatic or pulmonary colorectal metastases prolongs survival in selected patients. However, the benefits of resection and appropriate selection criteria in patients who develop both hepatic and pulmonary metastases are ill-defined. Methods: Data were prospectively collected from 131 patients with colorectal cancer who underwent resection of both hepatic and pulmonary metastases over a 20-year period. Median follow-up was 6.6 years from the time of resection of the primary tumor. Patient, treatment, and outcome variables were analyzed using log-ra

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Chan, Chung Ming, Adam D. Lindsay, Andre RV Spiguel, Mark T. Scarborough, and C. Parker Gibbs. "Brain metastases from Truncal and extremity bone and soft tissue sarcoma: Single institution study of oncologic outcomes." Rare Tumors 12 (January 2020): 203636132096006. http://dx.doi.org/10.1177/2036361320960060.

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Brain metastases are a rare occurrence in patients with sarcoma. The prognosis for patients is poor, and treatment can contribute to considerable morbidity. We sought to examine the experience of our institution in managing these patients over a period of 17 years. We performed a retrospective cohort study of patients managed for sarcoma of the extremity or trunk who developed brain metastases from 2000 to 2017. Clinical data were analyzed and we assessed survival outcomes. 14 patients presenting at a mean age of 46.7 years were included. All patients were treated with radiotherapy for their b

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Thornblade, Lucas W., Ernest Han, and Yuman Fong. "Colorectal cancer ovarian metastases." International Journal of Gynecologic Cancer 31, no. 8 (2021): 1137–44. http://dx.doi.org/10.1136/ijgc-2020-002328.

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ObjectiveOvarian metastases occur in 3%–5% of patients with colorectal cancer. The role of oophorectomy in that setting continues to be debated. We aimed to assess the survival of women treated with metastasectomy for ovarian metastasis.MethodsRetrospective cohort study of patients in the California Cancer Registry (2000–2012) with stage IV colorectal cancer and ovarian metastases. Pathology other than adenocarcinoma was excluded. Adjusted Cox-proportional hazard analysis was applied to assess the risk of death.ResultsA total of 756 patients with synchronous ovarian metastases and 516 patients

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Noronha, Vanita, Amit Joshi, Anant Gokarn, et al. "The Importance of Brain Metastasis in EGFR Mutation Positive NSCLC Patients." Chemotherapy Research and Practice 2014 (December 7, 2014): 1–4. http://dx.doi.org/10.1155/2014/856156.

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Introduction. Brain metastasis is a poor prognostic marker in lung cancer. However it is not known whether amongst patients with EGFR mutation those with brain metastases have a worse outcome. Methods. We compared the survival outcomes between EGFR mutation positive patients with and without brain metastases. In this retrospective analysis of prospective database of all metastatic lung cancer patients at our centre between July 2009 and December 2012, patients were treated with either combination chemotherapy or oral TKI. All patients with brain metastases received whole brain radiation. Kapla

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Muratori, Francesco, Leonardo Bettini, Filippo Frenos, et al. "Myxoid Liposarcoma: Prognostic Factors and Metastatic Pattern in a Series of 148 Patients Treated at a Single Institution." International Journal of Surgical Oncology 2018 (May 16, 2018): 1–9. http://dx.doi.org/10.1155/2018/8928706.

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Objectives. The authors reported a retrospective study on myxoid liposarcomas (MLs), evaluating factors that may influence overall survival (OS), local recurrence-free survival (LRFS), metastasis-free survival (MFS), and analyzing the metastatic pattern. Methods. 148 MLs were analyzed. The sites of metastases were investigated. Results. Margins (p = 0.002), grading (p = 0,0479), and metastasis (p < 0,0001) were significant risk factors affecting overall survival (OS). Type of presentation (p = 0.0243), grading (p = 0,0055), margin (p = 0.0001), and local recurrence (0.0437) were risk factor

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Choi, Hee Jun, Jai Min Ryu, Byung Joo Chae, et al. "Is Sentinel Lymph Node Biopsy for Breast Cancer with Cytology-Proven Axillary Metastasis Safe? A Prospective Single-Arm Study." Journal of Clinical Medicine 10, no. 20 (2021): 4754. http://dx.doi.org/10.3390/jcm10204754.

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The purpose of this study was to evaluate pathologic lymph node metastasis in breast cancer with cytology-proven axillary metastasis. This study was designed prospectively. We performed axillary lymph node dissections (ALND) after lymphatic mapping by near-infrared (NIR) fluorescence imaging with Indocyanine Green (ICG). We evaluated 72 breast cancer patients with cytology-proven axillary metastasis by curative surgery at the Samsung Medical Center between May of 2016 and December of 2017. Among the 72 patients with cytology-proven axillary metastasis, 14 of 39 patients (35.9%) with one or two

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Lai, Gu-Shun, Chuan-Shu Chen, Jason Chia-Hsien Cheng, et al. "Impact of different visceral metastatic sites on survival in metastatic prostate cancer patients." PLOS ONE 19, no. 9 (2024): e0309941. http://dx.doi.org/10.1371/journal.pone.0309941.

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Introduction Visceral metastasis is an important predictor for poor outcomes in prostate cancer, however, the prognostic significance surrounding the specific sites of visceral metastasis remains unclear. The aim of this study was to evaluate the impact of different visceral metastatic sites on survival in patients with prostate cancer. Methods We identified patients with metastatic prostate cancer between January 1, 2010 and December 31, 2023 using the TriNetX database. Patients were divided into 4 cohorts according to their specific metastatic sites: lung metastases, brain metastases, liver

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Omale, Malia. "Cardiac Metastases: Secondary Tumours of the Heart." International Journal of Sciences Volume 6, no. 2017-01 (2017): 73–77. https://doi.org/10.5281/zenodo.3349339.

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Cardiac metastases are secondary tumours of the heart that originate from primary malignancy in other parts of the body. Secondary tumours are mostly diagnosed during post-mortem examination. However, the incidence rate of secondary cardiac tumours is much greater that of primary cardiac tumours. Secondary tumours are often diagnosed using imaging techniques such as TEE, TTE, CT scans and MRI. In most cases, a combination of these imaging methods is necessary to accurately diagnose the presence of a secondary cardiac tumour. In addition, surgical excision is the primary treatment option of sec

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Yan, Tristan D., David R. Nunn, and David L. Morris. "Recurrence after Complete Cryoablation of Colorectal Liver Metastases: Analysis of Prognostic Features." American Surgeon 72, no. 5 (2006): 382–90. http://dx.doi.org/10.1177/000313480607200503.

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This study critically evaluated the prognostic determinants for disease-free survival (DFS) after cryoablation for colorectal liver metastases. An observational cohort study of prospectively collected data on 135 patients who underwent cryoablation with or without resection for colorectal liver metastases was performed. Univariate and multivariate analyses were used to determine the prognostic factors for overall DFS, cryosite DFS, remaining liver DFS, and extrahepatic DFS. Overall, 115 patients (85%) developed recurrence at the cryosite (44%), and the remaining patients developed recurrence a

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Dieterly, Alexandra M., Gozde Uzunalli, Chinyere M. Kemet, Arvin H. Soepriatna, Craig J. Goergen, and L. Tiffany Lyle. "Epithelial–mesenchymal Transition Phenotypes in Vertebral Metastases of Lung Cancer." Toxicologic Pathology 47, no. 4 (2019): 515–27. http://dx.doi.org/10.1177/0192623319838491.

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Vertebral metastases of non-small cell lung cancer (NSCLC) are frequently diagnosed in the metastatic setting and are commonly identified in the thoracic vertebrae in patients. Treatment of NSCLC bone metastases, which are often multiple, is palliative, and the median survival times are 3 to 6 months. We have characterized spontaneous vertebral metastases in a brain metastases model of NSCLC and correlated these findings with epithelial–mesenchymal transition (EMT). Brain metastases were established in athymic nude mice following intracardiac injection of brain-seeking adenocarcinoma NSCLC cel

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Waters, DJ, A. Honeckman, DM Cooley, and D. DeNicola. "Skeletal metastasis in feline mammary carcinoma: case report and literature review." Journal of the American Animal Hospital Association 34, no. 2 (1998): 103–8. http://dx.doi.org/10.5326/15473317-34-2-103.

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Despite the highly malignant nature of feline mammary carcinoma, few cases of skeletal metastasis have been reported. In this paper, a case of feline mammary carcinoma with skeletal metastasis to a distal limb is presented. The pertinent literature on feline mammary carcinoma and bone metastases is reviewed. Although the metastases of carcinomas in dogs and humans usually exhibit a proximal skeletal distribution, cats are more likely to develop distal extremity lesions. Clinicians need to have an index of suspicion that skeletal metastases may be responsible for lameness in elderly cats. Furth

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Ikram, Chamtouri, Amdouni Nesrine, Kaddoussi Rania, et al. "Case Report: Mitral valve obstruction by metastatic malignant phyllodes tumor." F1000Research 11 (July 25, 2022): 309. http://dx.doi.org/10.12688/f1000research.110022.2.

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Cardiac metastases are rare. Herein, we report a case of a 37-year-old female patient with a history of borderline breast phyllodes tumor (PT) treated by surgery, admitted to our department for concomitant cardiac and pulmonary metastases of malignant PT. Cardiac metastasis occurred through direct extension from pulmonary metastasis to the left atrium via the right inferior pulmonary vein, causing severe mitral valve obstruction. Although the total surgical removal of metastases, the patient had a huge relapse of the mediastinal metastasis resulting in her death.

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Zanib Javed, Raheema Sadiq, Hania Fatima, and Muhammad Shahzad Shamim. "Intramedullary Spinal Cord Metastasis in Spinal Ependymomas." Journal of the Pakistan Medical Association 75, no. 03 (2025): 509–11. https://doi.org/10.47391/jpma.25-22.

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Drop metastasis, or intramedullary spinal cord metastasis(ISCM), is a rare condition accounting 0.9%–5% of CNS orspinal metastases. It arises from tumour cell disseminationthrough cerebrospinal fluid (CSF), often affecting thethoracic and lumbar spine. Clinical features include rapidlyprogressive neurological deficits, limb weakness, sensoryloss, and pain. Diagnosing drop metastasis is challengingand MRI with gadolinium remains the gold standardmodality for investigation. Surgical resection followed byradiotherapy remains the primary treatment option,whereas chemotherapy serves a palliative ro

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Salati, Sajad Ahmad, Mohammed Alfehaid, Lamees Sulaiman Alsulaim, Saleh Ahmad Alsuwaydani, and Mohammed Ahmed Elmuttalut. "Uterine Metastasis from Carcinoma of Breast – A Systematic Analysis." Journal of Analytical Oncology 12 (July 10, 2023): 53–71. http://dx.doi.org/10.30683/1927-7229.2023.12.07.

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Breast cancer can metastasize to a wide range of organs, but reports about uterine metastases are rare. The current article systematically analyzes 55 patients reported in peer-reviewed literature from 2010–2022 with respect to nine variables, including: [i] age of the patient; [ii] clinical presentation of uterine metastasis; [iii] precise location of metastasis; [iv] primary (breast) cancer histopathology; [v] imaging modality utilized for detection of metastasis; [vi] timing of appearance of metastases: synchronous or metachronous; [vii] immunochemistry markers; [viii] management; and [ix]

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Wang, Yuzhuo, Xianfeng Xu, Jinyu Zheng, et al. "Mutational landscape and evolutionary pattern of peritoneal metastases in colorectal cancer." Journal of Clinical Oncology 42, no. 16_suppl (2024): e15533-e15533. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e15533.

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e15533 Background: Peritoneal metastases occur in approximately 10% of all colorectal cancer (CRC) patients, which are associated with significant morbidity and worse clinical outcome. To date, the evolutionary pattern and molecular mechanisms of peritoneal metastases remains largely unknown, which provided little insights into the prevention and treatment of this subgroup of CRC patients. Methods: We performed whole-exome sequencing (WES) on 49 samples of matched primary tumors, peritoneal metastases, and lymph node metastases from 11 CRC patients. Phylogenetic reconstruction and evolutionary

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Özer, Özge, Emirhan Nemutlu, Cemil Can Eylem, et al. "Detection of brain metastasis by metabolomics methods in metastatic breast cancer patients." Journal of Clinical Oncology 37, no. 15_suppl (2019): e12572-e12572. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e12572.

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e12572 Background: The aim of this study was to identify markers for the early diagnosis of brain metastasis by metabolomic methods in breast cancer patients. Methods: A total of 88 breast cancer patients with distant metastases were included the study. The patients were divided into two groups according to their metastasis status as patients with brain metastases and patients with distant metastases without any brain metastases. For metabolomic analyses, liquid chromatography quadrupole time-of-flight mass spectrometry (LC-qTOF-MS) and gas chromatography mass spectrometry (GC-MS) analysis met

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Mi, Kaihong, Michael J. McNamara, Xuefei Jia, Yazeed Sawalha, Katherine Glass, and Alok A. Khorana. "Outcomes after resection of pulmonary metastases in patients with colorectal cancer." Journal of Clinical Oncology 34, no. 4_suppl (2016): 757. http://dx.doi.org/10.1200/jco.2016.34.4_suppl.757.

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757 Background: Surgical resection of liver metastases provides a significant survival benefit, and potential for cure, in selected patients with metastatic colorectal cancer. There are very limited data on resection of lung metastases in patients with colorectal lung metastases. We evaluated outcomes after resection of lung metastases in patients with colorectal cancer. Methods: We conducted a retrospective cohort study in patients who underwent resection of pulmonary metastases between 2/2006 and 6/2013 at Cleveland Clinic. Clinical, pathologic, and outcome data were collected by electronic

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Wang, Yuezhu, Margaret R. Smith, Yin Liu, et al. "Abstract 3782: IASLC grading system predict distant metastases for resected lung adenocarcinoma." Cancer Research 84, no. 6_Supplement (2024): 3782. http://dx.doi.org/10.1158/1538-7445.am2024-3782.

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Abstract The International Association for the Study of Lung Cancer (IASLC) proposed a new histological grading system for invasive lung adenocarcinoma (LUAD). However, whether this new grading system is able to predict distant metastases in LUAD patients has not been evaluated. This study investigated the feasibility of using this grading system to predict the occurrence of brain and bone metastases in patients with resectable LUAD which identifies patients who have a high probability of developing distant metastases after surgery. We collected clinical information and pathological reports of

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Vlasov, Oleg, Sergey Tkachev, and Vasiliy Prorokov. "COLORECTAL CANCER AND FEATURES OF ITS METASTASIS." Problems in oncology 63, no. 3 (2017): 450–55. http://dx.doi.org/10.37469/0507-3758-2017-63-3-450-455.

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The article analyzes the frequency of regional metastasis detection in patients with operative colorectal cancer as well as the frequency and patterns of the appearance of distant metastases depending on the presence or absence of regional metastases, tumor localization and the method of treatment. It was found that the frequency of distant metastases in colorectal cancer depended mainly on the presence or absence of metastases in the regional lymph nodes. Some influence on the decrease in the frequency of distant metastasis was exacerbated by the preoperative radiation exposure by radiomodifi

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Si, Ming-Sing, Farin Amersi, S. Raymond Golish, et al. "Prevalence of Metastases in Hepatocellular Carcinoma: Risk Factors and Impact on Survival." American Surgeon 69, no. 10 (2003): 879–85. http://dx.doi.org/10.1177/000313480306901012.

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The purpose of this study was to determine the prevalence and risk factors of metastases in hepatocellular carcinoma (HCC) patients and analyze the effects of different locations of metastases on survival. Retrospective analysis was performed on 347 HCC patients who received a metastatic workup including bone scan and computed tomography scans of chest, abdomen, and pelvis. Clinical and tumor characteristics were evaluated as risk factors for metastasis by univariate and multivariate methods. Survival was analyzed by Kaplan-Meier and Cox regression methods. One hundred forty-five patients had

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Chen, Yu, Yayi He, Chao Zhao, Xuefei Li, Caicun Zhou, and Fred R. Hirsch. "Treatment of spine metastases in cancer: a review." Journal of International Medical Research 48, no. 4 (2019): 030006051988810. http://dx.doi.org/10.1177/0300060519888107.

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As a consequence of the improvements in diagnostic technology along with gains in life expectancy of cancer patients, the incidence of spine metastases has increased. Spine metastases can affect the patient’s quality of life and negatively impact on their prognosis. Multidisciplinary treatments involve surgery, chemotherapy, radiosurgery and radiotherapy. Spine metastases should be treated using a multidisciplinary and integrated approach that involves spinal surgeons, medical oncologists and radiologists. More research is required to elucidate the pathological mechanisms involved in the aetio

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Lee, Won-Chul, Daniel Richard Gomez, Jianhua Zhang, et al. "Comprehensive molecular and immune profiling of non-small cell lung cancer and matched distant metastases to suggest distinct molecular mechanisms underlying metastasis." Journal of Clinical Oncology 35, no. 15_suppl (2017): 8541. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.8541.

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8541 Background: Despite complete resection, many non-small cell lung cancer (NSCLC) patients still develop and succumb to distant metastases. Previous studies suggested distant metastasis may be due to genomic evolution and/or suppressed immune surveillance. However, the relationship between specific genomic alterations and immune surveillance has not been systemically studied. Methods: We performed whole exome sequencing, RNA-Seq, methylation microarray, immunohistochemistry using multiple immune markers, and T cell receptor sequencing on 7 pairs of NSCLC primary tumors and matched metastase

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Suki, Dima, Rami Khoury Abdulla, Minming Ding, Soumen Khatua, and Raymond Sawaya. "Brain metastases in patients diagnosed with a solid primary cancer during childhood: experience from a single referral cancer center." Journal of Neurosurgery: Pediatrics 14, no. 4 (2014): 372–85. http://dx.doi.org/10.3171/2014.7.peds13318.

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Object Metastasis to the brain is frequent in adult cancer patients but rare among children. Advances in primary tumor treatment and the associated prolonged survival are said to have increased the frequency of brain metastasis in children. The authors present a series of cases of brain metastases in children diagnosed with a solid primary cancer, evaluate brain metastasis trends, and describe tumor type, patterns of occurrence, and prognosis. Methods Patients with brain metastases whose primary cancer was diagnosed during childhood were identified in the 1990–2012 Tumor Registry at The Univer

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Jajja, Salman Ayub, Syed Arsalan Ahmed Naqvi, Muhammad Ali Khan, et al. "Survival in advanced prostate cancer (PCa) patients with visceral metastasis: A population-based SEER study." Journal of Clinical Oncology 43, no. 5_suppl (2025): 134. https://doi.org/10.1200/jco.2025.43.5_suppl.134.

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134 Background: Prostate cancer patients with visceral metastases at diagnosis are often treated using one-size-fits-all approach. For example, CHAARTED criteria treats any visceral metastasis as high volume. Therefore, we aimed to assess overall survival (OS) by site of visceral involvement in patients with metastatic PCa. Methods: Surveillance, Epidemiology, and End Results (SEER) database (2010-2021) was queried to obtain case listing data on metastatic PCa patients from 17 registries. The patients were categorized into three groups based on visceral metastasis at diagnosis: lung metastasis

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Otsuka. "Cutaneous Metastases in Ovarian Cancer." Cancers 11, no. 9 (2019): 1292. http://dx.doi.org/10.3390/cancers11091292.

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Skin metastases in ovarian cancer are uncommon, but their incidence may be increasing due to improved survival rates. Skin metastases can be divided into umbilical metastases, which are known as Sister Joseph nodules (SJNs) and are associated with peritoneal metastasis, and non-SJN skin metastases, which usually develop within surgical scars and in the vicinity of superficial lymphadenopathy. As most skin metastases develop after specific conditions, recognition of preceding metastatic diseases and prior treatments is necessary for early diagnosis of skin lesions. The prognosis of skin metasta

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Belov, D. M., V. B. Karakhan, A. Kh Bekyashev, et al. "Surgical treatment of patients with multiple brain metastases." Head and Neck Tumors (HNT) 14, no. 1 (2024): 31–38. http://dx.doi.org/10.17650/2222-1468-2024-14-1-31-38.

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Introduction. The standard of treatment for patients with single cerebral metastases is surgery and radiosurgery. The use of these methods significantly increases survival rates.Aim. To compare the results of surgical treatment of patients with single and multiple cerebral metastases.Materials and methods. The study included 40 patients with single and multiple cerebral metastases who underwent neurosurgical intervention in the neuro-oncology department of the N.N. Blokhin National Medical Oncology Research Center from 2010 to 2022.Results. All patients are divided into 3 groups. Group A inclu

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Li, Chuang, Zhao-zhong Meng, Jian-wu Qin, and Xin-guang Qiu. "Analysis of Risk Factors of Level V Lymphatic Metastasis for Papillary Thyroid Carcinoma with pN1b." Journal of Oncology 2021 (August 18, 2021): 1–5. http://dx.doi.org/10.1155/2021/5562065.

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Objective. To explore the risk factors of level V lymphatic metastasis in papillary thyroid carcinoma (PTC) patients with pN1b. Methods. Patients were selected if they presented with a suspicious level III or IV lymph node metastasis and underwent surgery by hemi or total thyroidectomy with a lymph node dissection (levels III, IV, VI, and VII). For these patients, if frozen section showed a positive level III or IV node, then levels II and V nodes were resected. Univariate analysis was performed using the chi-square test for some factors, including age, sex, tumor location, multifocal lesions,

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Vasilev, Nikolay, Vladimir Perelmuter, Yevgeniy Choynzonov, et al. "ANALYSIS OF CASES WITH LYMPHOGENOUS METASTASIS FROM CHONDROSARCOMA." Problems in oncology 65, no. 5 (2019): 736–43. http://dx.doi.org/10.37469/0507-3758-2019-65-5-736-743.

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Between 2008 and 2017, 87 patients with lymphogenous metastasis from chondrosarcoma were treated at the Cancer Research Institute (Tomsk, Russia). Lymph node metastases were detected in 3 patients (3.4 %). All cases with lymphogenous metastases were characterized by the presence of the tumor in the appendicular skeleton, tumor extension beyond the bone with the formation of extraossal component, high-grade tumor (G2 and G3) and disease progression. Our study indicates the importance of the study of lymphogenous metastasis as evidence of an unfavorable outcome for chondrosarcoma. Further studie

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Qin, Lang, Xiangtian Yu, Chuang Xu, and Yangchen Liu. "Prognostic impact of metastatic patterns and treatment modalities on overall survival in lung squamous cell carcinoma: A population-based study." Medicine 102, no. 29 (2023): e34251. http://dx.doi.org/10.1097/md.0000000000034251.

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This study aimed to investigate the impact of distinct metastasis patterns on the overall survival (OS) of individuals diagnosed with organ metastatic lung squamous cell carcinoma (LUSC). OS was calculated using the Kaplan–Meier method, and univariate and multivariate Cox regression analyses were conducted to further assess prognostic factors. A total of 36,025 cases meeting the specified criteria were extracted from the Surveillance, Epidemiology, and End Results database. Among these patients, 30.60% (11,023/36,025) were initially diagnosed at stage IV, and 22.03% (7936/36,025) of these indi

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Law, Ngie Chang, and Christopher Lomma. "Pancreatic adenocarcinoma with brain metastases." BMJ Case Reports 16, no. 3 (2023): e253557. http://dx.doi.org/10.1136/bcr-2022-253557.

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Brain metastases are rare for patients with pancreatic adenocarcinoma. The incidence of brain metastasis may increase as improved systemic treatment regimens improve overall survival. Given the low incidence of brain metastasis, recognition of disease and management remain a challenge. We report three cases of metastatic pancreatic adenocarcinoma with brain metastases, review the literature and discuss its management principles.

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Gogia, Pooja, Jonathan Wallach, Anil Kumar Dhull, and Sidharth Bhasin. "Multiple cutaneous and haemorrhagic brain metastases as the sentinel presentation of lung adenocarcinoma." BMJ Case Reports 13, no. 11 (2020): e235938. http://dx.doi.org/10.1136/bcr-2020-235938.

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Skin is a relatively uncommon site of metastasis in lung cancer and is associated with a poor prognosis. Although, lung cancer does not uncommonly metastasise to the brain, haemorrhagic brain metastases are rarely reported. In this report, we present a dramatic presentation of a female smoker with a 3-week history of numerous cutaneous lesions over her body and two episodes of transient memory loss. Work-up demonstrated widely metastatic, poorly differentiated lung adenocarcinoma with haemorrhagic brain metastases. She proceeded with whole brain radiotherapy, but her performance status quickly

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Kim, Woo Young, Jeonghun Lee, and Euy-Young Soh. "Oral Presentation VI." World Journal of Endocrine Surgery 8, no. 1 (2016): 34–39. http://dx.doi.org/10.5005/wjoes-8-1-34.

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ABSTRACT BACKGROUND AND AIMS Papillary thyroid cancer (PTC) is the most frequent subtype among thyroid cancers. Lymph node (LN) metastases are frequent in PTC and the incidence is 60% on average. Recent studies have shown that there has been an increase in the mortality or recurrence with LN metastases and that more than 5 metastatic LNs are clinically important. Therefore, we investigated clinicopathologic factors associated with clinically important LN metastases. METHODS From January 2010 to October 2013, we retrospectively enrolled 2,628 PTC patients who underwent thyroidectomy at Ajou Uni

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Jiang, Chuang, Zhi-Hong Zhang, and Jia-Xin Li. "Consideration on immunotherapy of liver metastases of malignant tumors." World Journal of Gastrointestinal Surgery 16, no. 8 (2024): 2374–81. http://dx.doi.org/10.4240/wjgs.v16.i8.2374.

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In this editorial, we comment on the article “Analysis of the impact of immunotherapy efficacy and safety in patients with gastric cancer and liver metastasis” by Liu et al that was published in the recent issue of the World Journal of Gastrointestinal Surgery . It has prompted us to think and summarize some thoughts on immunotherapy for malignant tumor liver metastasis. Immunotherapy plays a crucial role in the treatment of malignant tumors; however, the presence of liver metastases in advanced tumors may impact its efficacy. Although patients with liver metastases can still benefit from immu

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Crnalic, S., E. Hörnberg, P. Wikström, et al. "Nuclear androgen receptor staining in bone metastases is related to a poor outcome in prostate cancer patients." Endocrine-Related Cancer 17, no. 4 (2010): 885–95. http://dx.doi.org/10.1677/erc-10-0059.

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Androgen receptors (ARs) are probably of importance during all phases of prostate cancer (PC) growth, but their role in bone metastases is largely unexplored. Bone metastases were therefore collected from hormone-naive (n=11), short-term castrated (n=7) and castration-resistant PC (CRPC, n=44) patients by biopsy (n=4) or at surgery to alleviate symptoms from metastases complications (metastasis surgery, n=58), and immunostained for nuclear ARs, Ki67, active caspase-3, prostate-specific antigen (PSA) and chromogranin A, and results were related to serum PSA, treatments and outcome. Nuclear AR i

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Váraljai, Renáta, Susanne Horn, Antje Sucker, et al. "Integrative Genomic Analyses of Patient-Matched Intracranial and Extracranial Metastases Reveal a Novel Brain-Specific Landscape of Genetic Variants in Driver Genes of Malignant Melanoma." Cancers 13, no. 4 (2021): 731. http://dx.doi.org/10.3390/cancers13040731.

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Background: Development of brain metastases in advanced melanoma patients is a frequent event that limits patients’ quality of life and survival. Despite recent insights into melanoma genetics, systematic analyses of genetic alterations in melanoma brain metastasis formation are lacking. Moreover, whether brain metastases harbor distinct genetic alterations beyond those observed at different anatomic sites of the same patient remains unknown. Experimental Design and Results: In our study, 54 intracranial and 18 corresponding extracranial melanoma metastases were analyzed for mutations using ta

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Stanishevskiy, A. V., Sh Kh Gizatullin, A. V. Smolin, and E. V. Kryukov. "Surgical treatment of solitare brain metastases." Russian journal of neurosurgery 24, no. 2 (2022): 17–24. http://dx.doi.org/10.17650/1683-3295-2022-24-2-17-24.

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Background. Brain metastasis occurs in 10–30 % of patients with different malignances. Despite of successes, achieved in the treatment of extracranial malignances in last decade, tendency to increase of the survival and duration of the disease-free period in patients with brain metastasis is absent. Several treatment modalities: chemotherapy, radiation, immune and target therapy, stereotactic radiosurgery, different types of surgical procedures, however, an optimal combination of these methods remain unclear.The aim of the study: to summarize experience of complex treatment of patients with br

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Sheehan, Jason P., Chun-Po Yen, James Nguyen, Jessica A. Rainey, Kasandra Dassoulas, and David J. Schlesinger. "Timing and risk factors for new brain metastasis formation in patients initially treated only with Gamma Knife surgery." Journal of Neurosurgery 114, no. 3 (2011): 763–68. http://dx.doi.org/10.3171/2010.2.jns091539.

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Object Stereotactic radiosurgery has been shown to afford a reasonable chance of local tumor control. However, new brain metastasis can arise following successful local tumor control from radiosurgery. This study evaluates the timing, number, and risk factors for development of subsequent new brain metastasis in a group of patients treated with stereotactic radiosurgery alone. Methods One hundred seventeen patients with histologically confirmed metastatic cancer underwent Gamma Knife surgery (GKS) to treat all brain metastases demonstrable on MR imaging. Patients were followed clinically and r

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