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Tesis sobre el tema "Method for DNA methylation"

Autor: Grafiati

Publicado: 11 de marzo de 2023

Última modificación: 31 de julio de 2025

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1

Meng, Wei. "DNA Mutation/Methylation Screening Method for Colon Cancer Screening." Cleveland State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=csu1290364705.

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2

Trimarchi, Michael Paul Trimarchi. "Identification of endometrial cancer methylation features using a combined methylation analysis method." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1461302615.

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3

ZERILLI, FRANCESCO. "Development of an isothermal method for the detection of DNA hypermethylation." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2009. http://hdl.handle.net/10281/7481.

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This thesis relates to the development of an isothermal method for the detection of DNA hypermethylation. The function of DNA methylation is to silence specific areas of the human genome and its maintenance is necessary to regulate key functions of the cell and of the organism. Aberrant hypermethylation of the promoter regions of several tumor suppressor genes can lead to formation of tumors and its detection, even at very early stages, can be an useful and powerful instrument for the diagnosis of the cancer, the determination of the prognosis and also to gauge the therapy. In this work we dev

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4

Hu, Ke. "METHODS AND ANALYSES IN THE STUDY OF HUMAN DNA METHYLATION." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1522760441838452.

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5

Van, Heerden Chrisna. "Establishing a method for measuring the DNA methylation status of specific human genes / Chrisna van Heerden." Thesis, North-West University, 2006. http://hdl.handle.net/10394/1443.

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6

Antunes, Joana AP. "The Study of Tissue-Specific DNA Methylation as a Method for the Epigenetic Discrimination of Forensic Samples." FIU Digital Commons, 2017. https://digitalcommons.fiu.edu/etd/3676.

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In forensic sciences, the serological methods used to determine which body fluid was collected from the crime scene are merely presumptive or labor intensive since they rely on protein detection or on microscopic identification of cells. Given that certain forensic cases may need the precise identification of a body fluid to determine criminal contact, such is the example of a suspected sexual assault of a minor; certainty in the body fluid of origin may depict a precise picture of the events. The identification of loci that show differences in methylation according to the tissue of origin can

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7

Capparuccini, Maria. "Inferential Methods for High-Throughput Methylation Data." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/156.

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The role of abnormal DNA methylation in the progression of disease is a growing area of research that relies upon the establishment of sound statistical methods. The common method for declaring there is differential methylation between two groups at a given CpG site, as summarized by the difference between proportions methylated db=b1-b2, has been through use of a Filtered Two Sample t-test, using the recommended filter of 0.17 (Bibikova et al., 2006b). In this dissertation, we performed a re-analysis of the data used in recommending the threshold by fitting a mixed-effects ANOVA model. It was

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8

Kretzmer, Helene. "Methods for DNA Methylation Sequencing Analysis and their Application on Cancer Data." Doctoral thesis, Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-203416.

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The fundamental subject of this thesis is the development of tools for the analysis of DNA methylation data as well as their application on bisulfite sequencing data comprising a large number of samples. DNA methylation is one of the major epigenetic modifications. It affects the cytosines of the DNA and is essential for the normal development of cells and tissues. Unusual alterations are associated with a variety of diseases and, specially, in cancergeneous tissues global changes in the DNA methylation level have been detected. To sequence DNA methylation on single nucleotide resolution, the

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9

Han, Chenggong. "Statistical models and computational methods for studying DNA differential methylation and 3D genome structure." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1595417277891892.

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10

Jackel, Jamie Nicole. "GEMINIVIRUSES AS MODELS TO STUDY THE ESTABLISHMENT AND MAINTENANCE OF DNA METHYLATION." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1367494030.

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11

Lutsik, Pavlo [Verfasser], and Jörn [Akademischer Betreuer] Walter. "Bioinformatic tools and computational methods for mapping DNA methylation variability / Pavlo Lutsik ; Betreuer: Jörn Walter." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2017. http://d-nb.info/1128148501/34.

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12

Lutsik, Pavlo Verfasser], and Jörn [Akademischer Betreuer] [Walter. "Bioinformatic tools and computational methods for mapping DNA methylation variability / Pavlo Lutsik ; Betreuer: Jörn Walter." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:291-scidok-67884.

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13

Yip, Wai-Ki. "Statistical Methods for Analyzing DNA Methylation Data and Subpopulation Analysis of Continuous, Binary and Count Data for Clinical Trials." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:14226106.

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DNA methylation may represent an important contributor to the missing heritability described in complex trait genetics. However, technology to measure DNA methylation has outpaced statistical methods for analysis. Novel methodologies are required to accommodate this growing volume of DNA methylation data. In this dissertation, I propose two novel methods to analyze DNA methylation data: (1) a new statistic based on spatial location information of DNA methylation sites to detect differentially methylated regions in the genome in case and control studies; and (2) a principal component approach f

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14

Kretzmer, Helene [Verfasser], Peter F. [Gutachter] Stadler, and Martin [Gutachter] Vingron. "Methods for DNA Methylation Sequencing Analysis and their Application on Cancer Data / Helene Kretzmer ; Gutachter: Peter F. Stadler, Martin Vingron." Leipzig : Universitätsbibliothek Leipzig, 2016. http://d-nb.info/1240481691/34.

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15

Rohde, Christian [Verfasser]. "Development of experimental and bioinformatics methods for high resolution DNA methylation analysis of gene promoters on human chromosome 21 / Christian Rohde." Bremen : IRC-Library, Information Resource Center der Jacobs University Bremen, 2009. http://d-nb.info/1034996371/34.

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16

Manser, Paul. "Methods for Integrative Analysis of Genomic Data." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3638.

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In recent years, the development of new genomic technologies has allowed for the investigation of many regulatory epigenetic marks besides expression levels, on a genome-wide scale. As the price for these technologies continues to decrease, study sizes will not only increase, but several different assays are beginning to be used for the same samples. It is therefore desirable to develop statistical methods to integrate multiple data types that can handle the increased computational burden of incorporating large data sets. Furthermore, it is important to develop sound quality control and normal

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17

Moreland, Blythe S. "Genome-wide studies of DNA and RNA with modifications through high-throughput sequencing analysis." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu153452875946939.

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18

Joulie, Michaël. "Recherche de nouvelles protéines humaines se liant à l'ADN méthylé." Thesis, Paris 11, 2011. http://www.theses.fr/2011PA112157/document.

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L'épigénétique est un composant essentiel du fonctionnement des génomes eucaryotes. Les divers phénomènes épigénétiques modifient l’état chromatinien et participent à la plasticité du génome, mais aussi au maintien de son identité fonctionnelle à travers les générations cellulaires. Parmi ces processus, la méthylation de l’ADN joue un rôle fondamental dans la régulation de l’expression des gènes.Chez les mammifères, la méthylation de l'ADN est associée à la répression transcriptionnelle, et elle remplit au moins trois fonctions essentielles. Premièrement, elle permet de réprimer les séquences

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19

Marchioretto, Lisa. "Development and validation of methods for genome-wide epigenetic analyses of human myogenic cells." Doctoral thesis, Università degli studi di Padova, 2014. http://hdl.handle.net/11577/3423853.

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Epigenetics is subjected to a pressing attention from the scientific community, because of its potential to explain the mechanisms of gene activation or repression. In this thesis I present a discovery-driven project aimed to the investigation of the epigenetic role in human myogenesis (and in particular the differentiation of myoblasts in myotubes). Studying epigenetics still presents significant hurdles, both experimental and computational. Therefore my first task was the establishment of robust protocols for investigating the role of epigenetics players during skeletal muscle differentiati

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20

Tasanasuwan, Piyama. "Targeted DNA methylation." Thesis, University of Sheffield, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251476.

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21

Mathot, Pauline. "Mécanismes épigénétiques et réponse des cellules cancéreuses au microenvironnement : implication de la méthylation de l’ADN et de l’un de ses interprètes, MBD2." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1163/document.

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Les cancers du sein ont la particularité de développer un microenvironnement tumoral important où les fibroblastes associés au cancer (CAF) jouent un rôle crucial dans la tumorigénèse via la sécrétion de différents facteurs de croissance, cytokines, protéases et composants de la matrice extracellulaire. Ces différents facteurs secrétés par les CAFs sont impliqués dans de nombreuses voies de signalisation suggérant que la reprogrammation des cellules cancéreuses par les CAFs peut affecter de nombreux gènes.Le séquençage des ARN messagers (RNAseq) de lignées cellulaires de cancer du sein cultivé

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22

MacLeod, A. Robert (Robert Alan) 1966. "DNA methylation and oncogenesis." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=39956.

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DNA methylation is a postreplicative covalent modification of the DNA which is catalysed by the DNA methyltransferase enzyme. DNA methylation plays an important role in controlling the gene expression profile of mammalian cells. The hypothesis presented in this thesis is that the expression of the DNA methyltransferase gene is upregulated by cellular oncogenic pathways, and that this induction of MeTase activity results in DNA hypermethylation and plays a causal role in cellular transformation. Novel DNA methyltransferase inhibitors may inhibit the excessive activity of DNA methyltransferase i

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23

Tavares, de Araujo Felipe. "DNA replication and methylation." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=37847.

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One of the main questions of modern biology is how our cells interpret our genetic and epigenetic information. DNA methylation is a covalent modification of the genome that is essential for mammalian development and plays an important role in the control of gene expression, genomic imprinting and X-chromosome inactivation (Bird and Wolffe, 1999; Szyf et al., 2000). Furthermore, changes in DNA methylation and DNA methyltransferase 1 (DNMT1) activity have been widely documented in a number of human cancers (Szyf, 1998a; Szyf et al., 2000).<br>In Escherichia coli, timing and frequency of initiati

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24

Villa, Raffaella. "Role of epigenetic modifications in acute promyelocytic leukemia." Doctoral thesis, Universitat Pompeu Fabra, 2007. http://hdl.handle.net/10803/7144.

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Mi trabajo ha estado enfocado en la implicación de los diferentes mecanismos epigenéticos de PML-RARa en la inducción de la leucemia promielocítica aguda (APL).<br/>En particular yo estudié el rol de MBD1, un miembro de la conservada familia de proteinas capaces de unirse al DNA metilado, demostrando que desempeña un papel importante en la progresión de la leucemia. De hecho, mostré que MBD1 es recruida por PML-RARa a sus promotores diana a través de los mecanismos mediados por HDAC3, participando por tanto en la represión transcripcional. Además, investigué hasta donde la metilación de la H3K

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25

Tsusaka, Takeshi. "Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation." Kyoto University, 2018. http://hdl.handle.net/2433/232305.

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26

Carrió, Gaspar Elvira. "DNA Methylation Dynamics during Myogenesis." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/296312.

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Myogenesis is the differentiation process which encompasses the formation of skeletal muscle during development, regeneration and tissue homeostasis throughout life. Arising from embryonic or adult stem cells, the myogenic process comprehends the acquisition of a specialized cell identity and the loss of pluri/multipotent and proliferative capacities. Starting with the hypothesis that DNA methylation, together with other epigenetic mechanisms and the transcription factors, orchestrates the transcriptional program, this thesis provides a comprehensive picture of DNA methylation dynamics during

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27

Wong, Nicholas Chau-Lun. "DNA methylation at the neocentromere /." Connect to thesis, 2006. http://eprints.unimelb.edu.au/archive/00001883.

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28

Akman, Kemal. "Bioinformatics of DNA Methylation analysis." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-182873.

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29

陳桂儀 and Kwai-yi Jacqueline Chan. "DNA methylation and pediatric cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31970370.

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30

Ó, Riain Ciarán Liam. "DNA methylation in follicular lymphoma." Thesis, Queen Mary, University of London, 2010. http://qmro.qmul.ac.uk/xmlui/handle/123456789/1318.

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Follicular Lymphoma (FL) is a common B cell Non-Hodgkin Lymphoma with a median survival of 8-10 years. Patients frequently undergo transformation to a more aggressive lymphoma and this is associated with drastically reduced survival. The hallmark of FL is the t(14;18) translocation yet this alone is insufficient for lymphomagenesis. While a number of secondary genetic changes have been described, epigenetic studies have lagged behind. Epigenetics refers to mechanisms that alter gene expression without a change in the primary DNA sequence. DNA methylation was quantitatively profiled at 1505 CpG

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31

Gonçalves, Athanásio Camila. "DNA methylation in Daphnia magna." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/7140/.

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Daphnia magna is gaining interest as a model for epigenetic research. It is easy to maintain under laboratory conditions and has low genetic diversity due to parthenogenetic reproduction. The D. magna genome is responsive to a wide range of stimuli and genomics resources are being developed for this species. Despite these great advantages, information regarding the epigenome of D. magna and its regulation is still lacking. Thus, the main aim of this work was to describe the methylome of D.magna and investigate its regulation and responsiveness to environmentally relevant exposure conditions. D

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32

McArthur, Michael. "Chromatin structure and DNA methylation." Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627534.

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33

Hunter, Jennifer Margaret. "Reprogramming a DNA methylation mutant." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25874.

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Chemical modification of the cytosine base via the addition of a methyl group to form 5-‐methylcytosine (5-‐mC) is a well-‐studied example of an epigenetic mark, which contributes to regulation of gene expression, chromatin organisation and other such cellular processes without affecting the underlying DNA sequence. In recent years it was shown that 5-‐mC is not the only DNA modification found within the vertebrate genome. 5-‐hydroxymethylcytosine (5-‐hmC) was first described in 1952 although it wasn’t until 2009 when it was rediscovered in mammalian tissues that it sparked intense inter

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34

Chan, Kwai-yi Jacqueline. "DNA methylation and pediatric cancer." Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B2515526x.

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35

Melquist, Stacey Michelle. "DNA methylation signaling in Arabidopsis." Available to US Hopkins community, 2002. http://wwwlib.umi.com/dissertations/dlnow/3068188.

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36

Poli, Elena. "DNA METHYLATION ANALYSIS IN RHABDOMYOSARCOMA." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424380.

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Rhabdomyosarcoma (RMS) is a highly aggressive pediatric soft-tissue sarcoma. It is mainly classified into two major subtypes characterized by alveolar (ARMS) and embryonal (ERMS) histologies. ARMS are characterized by a more aggressive behavior with a higher tendency to present metastasis at diagnosis and to relapse after treatment. Approximately 80% of ARMS harbour the reciprocal chromosomal translocation t(2;13)(q35;q14) and, less commonly, the variant translocation t(1;13)(p36;q14), in which PAX3 and FOXO1, or PAX7 and FOXO1 genes, respectively, are juxtaposed. Unfortunately, no such specif

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37

Gould, Poppy Aeron. "The role of DNA repair in DNA methylation dynamics." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/274360.

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The mammalian epigenome is globally reprogrammed at two stages of development; this involves the erasure and re-establishment of DNA methylation by both passive and active mechanisms, including DNA repair pathways, and occurs concurrently with an increase in developmental potency. In addition to Uhrf1 and the Tet enzymes, the interplay between activation induced cytidine deaminase (AID) and the DNA repair machinery has been implicated in epigenetic reprogramming of various in vivo and in vitro systems including mouse primordial germ cells, zygotes and induced pluripotent stem cells. AID deamin

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38

Tan, Choon Ping. "Control of mammalian DNA methylation system components by protein arginine methylation." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445922/.

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DNA methylation is essential for the survival and development of vertebrates. Methylated cytosine in the context of CpG-dinucleotides within the genome is recognized by proteins from the methyl-CpG DNA binding domain (MBD) family. When bound to methyl-CpG DNA, most MBD proteins can recruit histone deacetylase (HDAC) silencing complexes to the site of chromatin to remodel its structure, and this causes transcription repression. Loss of CpG-DNA methylation results in embryonic lethality in mice, but loss of methyl-CpG DNA recognizing MBD proteins produce a viable phenotype. Our interest in MBD p

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39

Hernando, Herráez Irene 1985. "Evolutionary insights into human DNA methylation." Doctoral thesis, Universitat Pompeu Fabra, 2015. http://hdl.handle.net/10803/392140.

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DNA methylation is a crucial epigenetic modification involved in numerous biological processes. However, despite its functional importance, the evolutionary history of this modification and the mechanisms diving such changes are poorly understood. The aim of this thesis is to provide a better understanding of DNA methylation in the context of human recent evolution. We identified and described hundreds of regions presenting a human-specific DNA methylation pattern compared to great apes. We also analyzed for the first time the relationship between DNA methylation changes and sequence evolution

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40

Mirbahai, Leda. "DNA methylation profiling of fish tumours." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3633/.

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Assessment of disease status in fish is used as an indicator of the biological effects of contaminants in the marine environment. At some UK offshore sites the prevalence of liver tumours in Limanda limanda (dab) exceeds 20%. However, the molecular mechanisms of tumour formation and the causative agents are not known. The contribution of epigenetic mechanisms, although well-established in human tumourigenesis, is under-studied in tumours of aquatic species. In this thesis, alteration in the DNA methylation patterns in tumours of two fish species, the model species zebrafish (Danio rerio) and t

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41

Chan, Michelle M. (Michelle Mei Wah). "DNA methylation in early mammalian development." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/81580.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Computational and Systems Biology Program, 2013.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>All the cells in the body contain the same genome yet showcase drastically different phenotypes. This is the result of different transcriptional programs, which are partly controlled by epigenetic modifications, including DNA methylation. In this thesis, I analyze genome-scale DNA methylation profiles across pre-implantation development to identify the targets and characterize the dynamics of global demethyl

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42

Patel, Yogen. "DNA methylation analysis of Alzheimer's disease." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/dna-methylation-analysis-of-alzheimers-disease(f66ad885-3fdd-4c12-a73a-921cc31ccac2).html.

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There is evidence for a role for epigenetic mechanisms in Alzheimer's disease (AD), the most common age-dependent neurodegenerative disorder. The most studied epigenetic mark DNA methylation -the addition of a methyl group to cytosines located in CpG dinucleotides (5mC) - is known to change with aging and may reflect subtle changes in gene expression. Recently a second type of modified cytosine - a hydroxylated and methylated form (5hmC) - has been detected in the brain and maybe linked to the regulation of gene expression. Case-control differences in post-mortem brain DNA methylation were sou

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43

Currie, Graeme M. "DNA methylation at cytosine position 5." Thesis, Aston University, 1992. http://publications.aston.ac.uk/12603/.

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DNA methylation appears to be involved in the regulation of gene expression. Transcriptionally inactive (silenced) genes normally contain a high proportion of 5-methyl-2'-deoxycytosine residues whereas transcriptionally active genes show much reduced levels. There appears good reason to believe that chemical agents capable of methylating 2'-deoxycytosine might affect gene expression and as a result of hypermethylating promoter regions of cytosine-guanine rich oncogenic sequences, cancer related genes may be silenced. This thesis describes the synthesis of a number of `electrophilic' S-methylsu

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44

Warnecke, Peter. "DNA methylation in early mammalian development." Thesis, The University of Sydney, 1998. https://hdl.handle.net/2123/27569.

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In mammalian genomes, the base cytosine is frequently modified to S-methylcytosine by the action of DNA methyltransferases. DNA methylation may affect gene expression within the cell by acting to repress transcription, and has been suggested to be involved in numerous cellular processes including tissue-specific gene control, repression of transposon activity, X-chromosome inactivation, genomic imprinting and tumourigenesis. While the pattern of mammalian DNA methylation is typically stable in the adult, widespread changes occur to genomic methylation levels during embryonic development

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45

Mischke, Mona. "DNA methylation of the POMC gene." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16456.

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Adipositas ist eine polymorphe chronische Erkrankung mit epidemischer Prävalenz. Im katabolen Leptin-Melanocortin-Signalweg ist das Proopiomelanocortin Gen (POMC) ein zentrales Element, das bei Dysfunktion massive Adipositas bewirken kann. Auch eine kürzlich identifizierte intragenische Methylierungsvariante des POMC wurde mit Adipositas assoziiert und deutet somit auf eine mögliche epigenetische Modulation des Gewichtsphänotyps hin. Zur Aufklärung der Relevanz, Stabilität und Entwicklung dieser epigenetischen Modifikation wurden die Funktionalität, Ontogenese und Phylogenese der POMC DNA-Meth

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46

Aguirre-Arteta, Ana Maria. "Regulation of DNA methylation during development." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2000. http://dx.doi.org/10.18452/14509.

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Die DNA Methyltransferasen sind verantwortlich für die spezifische Methylierung von DNA-Basen. Mehrere DNA Methyltransferasen sind bekannt, wobei die Dnmt1 das hauptsächlich vorkommende Enzym ist. Bei Säugetieren korreliert die DNA-Methylierung mit der Genaktivität und ist essentiell für die Embryonalentwicklung. Eine beeinträchtigte Funktion oder Verfügbarkeit des Enzyms kann zu pathologisch veränderten Zuständen führen. Die Regulation der Dnmt1 und die damit verbundene Bedeutung bei der Entstehung von Krankheiten ist bisher nur unvollständig untersucht. In der Frühphase der Embryonalentwickl

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47

Ibrahim, Abdulkhaleg. "Regulation of DNA methylation by DNA glycosylases MBD4 and TDG." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAJ019/document.

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Chez les mammifères, la méthylation est une marque épigénétique ciblant la cytosine principalement dans un contexte CpG pour produire une 5mC. 5mC est très sensible à une déamination spontanée ou enzymatique, conduisant à la formation d'un mésappariement G/T. La 5mCpeut également être oxydée pour former successivement la 5hmC, la 5fC et la 5caC. Ces modifications de la 5mC participent aux processus actifs de déméthylation de l’ADN. Chez les mammifères, la thymine, dans le mésappariement G/T, est clivée par TDG et MBD4. TDG est également en mesure d'exciser 5fC et 5caC. Cette thèse avait pour b

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48

Devailly, Guillaume. "Les protéines MBD2 et ZBTB4 répriment la transcription de nombreux gènes méthylés. MBD2 est redistribuée sur l’ADN méthylé dans des modèles de transformation oncogénique." Thesis, Lyon 1, 2014. http://www.theses.fr/2014LYO10316.

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La méthylation de l'ADN est une marque épigénétique répressive impliquée dans de nombreux processus physiologiques et pathologiques. Des hyperméthylations de promoteurs sont ainsi responsables de répressions transcriptionnelles de gènes suppresseurs de tumeurs dans les cancers. La méthylation de l'ADN serait capable d'induire une répression transcriptionnelle par la combinaison de deux mécanismes principaux : l'éloignement de facteurs de transcription activateurs, et le recrutement de protéines répressives liant spécifiquement l'ADN méthylé. MBD2 est une protéine de liaison à l'ADN méthylé cap

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49

Pichler, Garwin. "Crosstalk between DNA methylation and histone modifications." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-143799.

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50

Chik, Pui Chi Flora. "Targeting the DNA methylation machinery in cancers." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114316.

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Cancer cells have aberrant DNA methylation patterns which are characterized by hypomethylation of a large set of promoters and hypermethylation of tumor suppressor genes. The dynamic nature of the epigenome makes it a valuable target for therapeutic interventions. This thesis focuses on understanding the use of various inhibitors towards DNA methylation-related proteins and their respective anti-cancer activities at both global and gene-specific levels. The widely used demethylating agent 5-azacytidine and 5-aza-2'-deoxycytidine (5-azaCdR) are FDA-approved drugs for the treatment of myelodyspl

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