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Tesis sobre el tema "Microarrays"

Autor: Grafiati
Publicado: 4 de junio de 2021
Última modificación: 25 de julio de 2025

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1

Pernagallo, Salvatore. "Biocompatible polymer microarrays for cellular high-content screening." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/7571.

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The global aim of this thesis was to study the use of microarray technology for the screening and identification of biocompatible polymers, to understand physiological phenomena, and the design of biomaterials, implant surfaces and tissue-engineering scaffolds. This work was based upon the polymer microarray platform developed by the Bradley group. Polymer microarrays were successfully applied to find the best polymer supports for: (i) mouse fibroblast cells and used to evaluate cell biocompatibility and cell morphology. Fourteen polyurethanes demonstrated significant cellular adhesion. (ii) A
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2

Stephens, Nathan W. "A comparison of genetic microarray analyses : a mixed models approach versus the significance analysis of microarrays /." Diss., CLICK HERE for online access, 2006. http://contentdm.lib.byu.edu/ETD/image/etd1604.pdf.

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3

Marsden, David Michael. "3D small-molecule microarrays." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611660.

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4

Ooi, Siew Loon. "Yeast genetics of microarrays." Available to US Hopkins community, 2002. http://wwwlib.umi.com/dissertations/dlnow/3080738.

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5

Dvergsten, Erik C. "A Weighted Gene Co-expression Network Analysis for Streptococcus sanguinis Microarray Experiments." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4430.

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Streptococcus sanguinis is a gram-positive, non-motile bacterium native to human mouths. It is the primary cause of endocarditis and is also responsible for tooth decay. Two-component systems (TCSs) are commonly found in bacteria. In response to environmental signals, TCSs may regulate the expression of virulence factor genes. Gene co-expression networks are exploratory tools used to analyze system-level gene functionality. A gene co-expression network consists of gene expression profiles represented as nodes and gene connections, which occur if two genes are significantly co-expressed. An adj
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6

Harness, Denise. "A Comparison of Unsupervised Methods for DNA Microarray Leukemia Data." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/106.

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Advancements in DNA microarray data sequencing have created the need for sophisticated machine learning algorithms and feature selection methods. Probabilistic graphical models, in particular, have been used to identify whether microarrays or genes cluster together in groups of individuals having a similar diagnosis. These clusters of genes are informative, but can be misleading when every gene is used in the calculation. First feature reduction techniques are explored, however the size and nature of the data prevents traditional techniques from working efficiently. Our method is to use the pa
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7

Stephens, Nathan Wallace. "A Comparison of Microarray Analyses: A Mixed Models Approach Versus the Significance Analysis of Microarrays." BYU ScholarsArchive, 2006. https://scholarsarchive.byu.edu/etd/1115.

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DNA microarrays are a relatively new technology for assessing the expression levels of thousands of genes simultaneously. Researchers hope to find genes that are differentially expressed by hybridizing cDNA from known treatment sources with various genes spotted on the microarrays. The large number of tests involved in analyzing microarrays has raised new questions in multiple testing. Several approaches for identifying differentially expressed genes have been proposed. This paper considers two: (1) a mixed models approach, and (2) the Signiffcance Analysis of Microarrays.
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8

Brunner, Thomas. "Designing oligonucleotides for DNA microarrays /." Zürich : ETH, Eidgenössische Technische Hochschule Zürich, Department of Computer Science, 2003. http://e-collection.ethbib.ethz.ch/show?type=dipl&nr=116.

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9

Hartmann, Michael. "Microfluidic Methods for Protein Microarrays." Doctoral thesis, KTH, Analytisk kemi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-26083.

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Protein microarray technology has an enormous potential for in vitro diagnostics (IVD)1. Miniaturized and parallelized immunoassays are powerful tools to measure dozens of parameters from minute amounts of sample, whilst only requiring small amounts of reagent. Protein microarrays have become well-established research tools in basic and applied research and the first diagnostic products are already released on the market. However, in order for protein microarrays to become broadly accepted tools in IVD, a number of criteria have to be fulfilled concerning robustness and automation. Robustness
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10

Taylor, Michael. "Surface analysis of polymer microarrays." Thesis, University of Nottingham, 2009. http://eprints.nottingham.ac.uk/10717/.

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Polymers have been used as biomaterials for nearly a century and have recently become the material of choice for use in tissue engineering. However, the classes of biodegradable and biocompatible polymers available for use in biomedical devices and as tissue engineering scaffolds are limited. This lack of available polymers with suitable properties could inhibit the development of biomedical devices with improved biocompatibility and hinder the growth of the fledgling tissue engineering field. Researchers in the polymer and biomaterials fields have tried to remedy this problem by applying comb
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11

Tourniaire, Guilhem. "Polymer microarrays : development and applications." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/14562.

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Initial studies involved the development of a novel polymer microarray platform which would provide unsurpassed miniaturisation for polymer screening. This required substantial development and optimisation of several parameters and the best results were achieved by printing polymers dissolved in 1-methyl-2-pyrrolidinone and patterned using a contact microarrayer with solid pins. Microarray platforms were developed that used different substrates. The first one used a gold-coated substrate that quenched non-specifically bound fluorescently-labelled proteins, whereas the second utilised a hydroge
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12

Simmonte, Owens Matthew John. "Polymer microarrays for biomedical applications." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28953.

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Biocompatible polymers are used exhaustively within the biomedical arena, demonstrating a mechanical and chemical diversity that few other materials possess. As polymer technologies evolves to cater for new medical demands, even the most niche biomedical application becomes an achievable reality. However, the discovery of new polymers is hindered by the complexity and intricacy in which the biological milieu interacts with a new substrate, reducing the ability to predict the appropriateness of a certain polymer for a specific application. This drawback can be countered by the high-throughput e
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13

Venkateswaran, Seshasailam. "Biomedical applications of polymer microarrays." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28758.

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In my PhD polymer microarrays have been central in discovery of new materials for cardiovascular repair, cartilage tissue engineering and bacteria resistant medical devices. This has led to the work described in the following four chapters of my thesis. In the first part of my thesis polymers for the development of novel heart valve leaflets were identified. Diseased heart valves are currently replaced with the either synthetic or bioprosthetic (acellular xenografts) valve prostheses. While synthetic prosthesis have excellent durability, thromboembolic complications are frequent, requiring pat
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14

Ottesen, Vegar. "Bacterial Microarrays by Microcontact Printing : Development of a Method for Immobilizing Live Bacteria on Microarrays." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for fysikk, 2014. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-26120.

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Traditional microbiological experimental methods generally reveal population-wide statistics and are not capable of revealing variations between individual cells. In an effort to address this, a cheap, quick and easy means of producing micro-arrays with live bacteria immobilized on the array's coordinates has been developed. To achieve this, microcontact printing (µCP) was used to print circular PD ``islands'' onto a surface coated with either PEG or PVA. The bacteria, <i>Pseudomonas putida</i> KT2440 were successfully immobilized on approximately 97% of the printed islands, depend
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15

Dabney, Alan R. "The normalization of two-channel microarrays /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/9537.

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16

Smith, Kaleigh. "Towards quality control in DNA microarrays." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=79129.

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We present a framework for detecting degenerate probes in a DNA microarray that may add to measurement error in hybridization experiments. We consider four types of behaviour: secondary structure formation, self-dimerization, cross-hybridization and dimerization. The framework uses a well-established model of nucleic acid sequence hybridization and a novel method for the detection of patterns in hybridization experiment data. Our primary result is the identification of unique patterns in hybridization experiment data that are correlated with each type of degenerate probe behaviour. The
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17

Hansen, Anne Klara Brigitte. "Polymer microarrays for cell based applications." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/9902.

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The development and identification of new biomaterials that can replace specific tissues and organs is desirable. In the presented PhD thesis polymer microarrays were applied for the screening of polyacrylates and polyurethanes and evaluation for material discovery for applications in the life sciences. In the first part of the thesis, the largest polymer microarray ever made with more than 7000 features was fabricated and subsequently used for the screening of polyacrylates that can control the fate of human embryonic stem cells. As stem cells have unique properties that offer the potential o
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18

Arrais, Joel Perdiz. "Sistemas de informação para DNA microarrays." Doctoral thesis, Universidade de Aveiro, 2010. http://hdl.handle.net/10773/2232.

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Doutoramento em Engenharia Informática<br>O projecto de sequenciação do genoma humano veio abrir caminho para o surgimento de novas áreas transdisciplinares de investigação, como a biologia computacional, a bioinformática e a bioestatística. Um dos resultados emergentes desde advento foi a tecnologia de DNA microarrays, que permite o estudo do perfil da expressão de milhares de genes, quando sujeitos a perturbações externas. Apesar de ser uma tecnologia relativamente consolidada, continua a apresentar um conjunto vasto de desafios, nomeadamente do ponto de vista computacional e dos sistemas de
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19

Hoang, Tuyen. "Experimental design considerations for tissue microarrays." Diss., Restricted to subscribing institutions, 2004. http://proquest.umi.com/pqdweb?did=795970721&sid=14&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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20

Durbin, Blythe Pamela. "Data transformations for gene-expression microarrays /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2003. http://uclibs.org/PID/11984.

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21

Kapur, Karen Anita. "Low-level analysis of microarray probes on exon-targeting microarrays : modeling background, gene expression and cross-hybridization /." May be available electronically:, 2008. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.

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22

Guo, Ruijuan. "Sample comparisons using microarrays: - Application of False Discovery Rate and quadratic logistic regression." Digital WPI, 2008. https://digitalcommons.wpi.edu/etd-theses/28.

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In microarray analysis, people are interested in those features that have different characters in diseased samples compared to normal samples. The usual p-value method of selecting significant genes either gives too many false positives or cannot detect all the significant features. The False Discovery Rate (FDR) method controls false positives and at the same time selects significant features. We introduced Benjamini's method and Storey's method to control FDR, applied the two methods to human Meningioma data. We found that Benjamini's method is more conservative and that, after the number of
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23

Wang, Tao. "Statistical design and analysis of microarray experiments." Connect to this title online, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1117201363.

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Thesis (Ph. D.)--Ohio State University, 2005.<br>Title from first page of PDF file. Document formatted into pages; contains ix, 146 p.; also includes graphics (some col.) Includes bibliographical references (p. 145-146). Available online via OhioLINK's ETD Center
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24

Fujita, André. "Análise de dados de expressão gênica: normalização de microarrays e modelagem de redes regulatórias." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/95/95131/tde-14092007-173758/.

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A análise da expressão gênica através de dados gerados em experimentos de microarrays de DNA vem possibilitando uma melhor compreensão da dinâmica e dos mecanismos envolvidos nos processos celulares ao nível molecular. O aprimoramento desta análise é crucial para o avanço do conhecimento sobre as bases moleculares das neoplasias e para a identificação de marcadores moleculares para uso em diagnóstico, desenho de novos medicamentos em terapias anti-tumorais. Este trabalho tem como objetivos o desenvolvimento de modelos de análise desses dados, propondo uma nova forma de normalização de dados pr
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25

Cristo, Elier Broche. "Métodos estatísticos na análise de experimentos de microarray." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/45/45133/tde-06062007-112551/.

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Neste trabalho é proposto um estudo comparativo de alguns métodos de Agrupamento (Hierárquico, K-médias e Self-Organizing Maps) e de Classificação (K-Vizinhos, Fisher, Máxima Verossimilhança, Aggregating e Regressão Local), os quais são apresentados teoricamente. Tais métodos são testados e comparados em conjuntos de dados reais, gerados com a técnica de Microarray. Esta técnica permite mensurar os níveis de expressão de milhares de genes simultaneamente, possibilitando comparações entre amostras de tecidos pelos perfis de expressão. É apresentada uma revisão de conceitos básicos relacionados
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26

Bonilla, Aguilar Diana Lisette. "Sistema de lectura eléctrica de microarrays proteomicos." Doctoral thesis, Universitat Autònoma de Barcelona, 2013. http://hdl.handle.net/10803/129451.

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En esta tesis se presenta un sistema de lectura eléctrica de microarrays que comprenden una serie de transductores impedimétricos con los cuales realizar la detección multiplexada de hasta 36 eventos biológicos en un mismo sustrato. Al igual que con los microarrays de lectura fluorescente, se han empleado sustratos de vidrio desechables para la fabricación del microarray. Sin embargo, a diferencia de ellos , el sistema presentado es compacto y requiere una instrumentación sencilla y de bajo coste, lo que hace que el sistema pueda ser muy útil para realizar la descentralización de este tipo de
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27

Steller, Sigrid. "Analyse von Neisseria meningitidis mit Protein-Microarrays." [S.l.] : [s.n.], 2005. http://www.diss.fu-berlin.de/2005/88/index.html.

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28

Sundberg, Mårten. "Protein microarrays for validation of affinity binders." Licentiate thesis, KTH, Proteomik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-48256.

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Is specificity an important issue regarding affinity reagents? What about the validation of affinity reagents today, is it good enough? This depends on the application and the producer of the reagent. Validation should be the most important marketing argument that can be found.Today there is a continuous growth of both the number of affinity reagents that are produced and the different types of affinity reagents that are developed. In proteomics they become more and more important in exploring the human proteome. Therefore, validated affinity reagents should be on top of every proteomic resear
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29

Lindskog, Bergström Cecilia. "Tissue Microarrays for Analysis of Expression Patterns." Doctoral thesis, Uppsala universitet, Molekylär och morfologisk patologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-186272.

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Proteins are essential building blocks in every living cell, and since the complete human genome was sequenced in 2004, researchers have attempted to map the human proteome, which is the functional representation of the genome. One such initiative is the Human Protein Atlas programme (HPA), which generates monospecific antibodies towards all human proteins and uses these for high-throughput tissue profiling on tissue microarrays (TMAs). The results are publically available at the website www.proteinatlas.org. In this thesis, TMAs were used for analysis of expression patterns in various researc
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30

Cheng, Hui-Yin Patricia. "Towards microarrays of fluorescent odorant binding proteins." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.509508.

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31

Wu, Mei. "Polymer microarrays for microbial high-content screening." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/7664.

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Research on the interactions between microbes and polymeric materials constitutes an important part in antimicrobial identification and provides an insight into microbial response on the polymer surfaces. Herein, a high-content screening method with polymer microarray technology was developed to investigate microbe-polymer interactions, especially in studying adhesion/repellence of microbes (bacteria and parasites). Firstly, the polymer microarray approach was used to successfully identify polymers which either selectively captured or prevented the binding of major food-borne pathogen, Salmone
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32

Chow, Brian 1978. "Photoelectromechanical synthesis of low-cost DNA microarrays." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/42405.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, School of Architecture and Planning, Program in Media Arts and Sciences, 2008.<br>Includes bibliographical references.<br>Recent advances in de novo gene synthesis, library construction, and genomic selection for target sequencing using DNA from custom microarrays have demonstrated that microarrays can effectively be used as the world's cheapest sources of complex oligonucleotide pools. Unfortunately, commercial custom microarrays are expensive and not easily accessible to academic researchers, and technical challenges still exist for dea
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33

Adib, Tania Rafid. "Gene expression microarrays of serous ovarian adenocarcinoma." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1445293/.

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Ovarian cancer has the highest mortality rate of the gynaecological cancers. This is partly due to the lack of effective screening markers. In this study, oligonucleotide microarrays complementary to -12,000 genes were used to establish a gene expression microarray (GEM) profile for normal ovarian tissue, as compared to stage III ovarian serous adenocarcinoma and omental metastases from the same individuals. The GEM profiles of the primary and secondary tumours from the same individuals were essentially alike, reflecting the fact that these tumours had already metastasised and acquired the met
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34

Dunning, Mark J. "Genome-wide analyses using bead-based microarrays." Thesis, University of Cambridge, 2008. https://www.repository.cam.ac.uk/handle/1810/218542.

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Microarrays are now an established tool for biological research and have a wide range of applications. In this thesis I investigate the BeadArray microarray technology developed by Illumina. The design of this technology is unique and gives rise to many computational and statistical challenges. However, I show how knowledge from other microarray technologies can be used to our advantage. I describe the beadarray software package, which is now used by researchers around the world. The development of this software was motivated by the fact that Illumina's software (BeadStudio) gives a summarised
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35

Silva, Luís Miguel Almeida da. "Selecção de variáveis em microarrays de ADN." Master's thesis, Universidade do Porto. Reitoria, 2003. http://hdl.handle.net/10216/9767.

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Dissertação de Mestrado em Estatística apresentada à Faculdade de Ciências da Universidade do Porto<br>A aplicação de um regime específico de quimioterapia, depende de um correcto diagnóstico do paciente. Actualmente, esse diagnóstico não é efectuado de uma forma sistemática e geral, necessitando da intervenção de diferentes especialistas. Com a monitorização da expressão de milhares de genes em simultâneo, a recente tecnologia dos microarrays de ADN representa um grande passo para a sistematização do diagnóstico oncológico. No entanto, esta tecnologia produz informação em que o número de vari
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36

Roth, Alexander David. "Modeling Liver Diseases Using Hepatic Cell Microarrays." Cleveland State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=csu1544719407531728.

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37

Herschkowitz, Jason I. Perou Charles M. "Breast cancer subtypes, mouse models, and microarrays." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1728.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2008.<br>Title from electronic title page (viewed Sep. 16, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Curriculum of Genetics and Molecular Biology." Discipline: Genetics and Molecular Biology; Department/School: Medicine.
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38

Horschinek, Andreas. "DNA-Microarrays zur therapiebegleitenden Prognose bei Brustkrebs." [S.l. : s.n.], 2006. http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-27654.

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39

Silva, Luís Miguel Almeida da. "Selecção de variáveis em microarrays de ADN." Dissertação, Universidade do Porto. Reitoria, 2003. http://hdl.handle.net/10216/9767.

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Dissertação de Mestrado em Estatística apresentada à Faculdade de Ciências da Universidade do Porto<br>A aplicação de um regime específico de quimioterapia, depende de um correcto diagnóstico do paciente. Actualmente, esse diagnóstico não é efectuado de uma forma sistemática e geral, necessitando da intervenção de diferentes especialistas. Com a monitorização da expressão de milhares de genes em simultâneo, a recente tecnologia dos microarrays de ADN representa um grande passo para a sistematização do diagnóstico oncológico. No entanto, esta tecnologia produz informação em que o número de vari
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40

Brus, Ole. "A comparison of normalisatin methods for peptide microarrays." Thesis, Uppsala University, Department of Mathematics, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-119970.

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41

Baldracchini, Francesca. "Protein microarrays for differential diagnosis of infectious diseases." Thesis, Imperial College London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501435.

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42

Hardy, Sinead M. "Nanoparticles versus microarrays in the detection of erythropoietin." Thesis, University of East Anglia, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502039.

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Horseracing is a huge industry both nationally and internationally. With large financial rewards now available at some meetings the pressure to excel has grown and as a result the desire to win has led some racehorse owners to resort to the use of performance enhancing drugs. Rumours concerning the abuse of recombinant human erythropoietin (rHuEPO) in thoroughbred horseracing have been circulating since it became readily available in the late 1980s. While there are a number of commercially available EPO enzyme-linked immunosorbent assays (ELlSAs) to detect the administration of rHuEPO to horse
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43

Arteaga-Salas, Jose Manuel. "Statistical treatment of spatial flaws in oligonucleotide microarrays." Thesis, University of Essex, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.510491.

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44

Laurenson, Sophie. "The development and application of peptide aptamer microarrays." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613244.

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45

Udall, Joshua, Lex Flagel, Foo Cheung, et al. "Spotted cotton oligonucleotide microarrays for gene expression analysis." BioMed Central, 2007. http://hdl.handle.net/10150/610000.

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BACKGROUND:Microarrays offer a powerful tool for diverse applications plant biology and crop improvement. Recently, two comprehensive assemblies of cotton ESTs were constructed based on three Gossypium species. Using these assemblies as templates, we describe the design and creation and of a publicly available oligonucleotide array for cotton, useful for all four of the cultivated species.RESULTS:Synthetic oligonucleotide probes were generated from exemplar sequences of a global assembly of 211,397 cotton ESTs derived from >50 different cDNA libraries representing many different tissue types a
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46

Shukla, Maulik. "GeneSieve: A Probe Selection Strategy for cDNA Microarrays." Thesis, Virginia Tech, 2004. http://hdl.handle.net/10919/10114.

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The DNA microarray is a powerful tool to study expression levels of thousands of genes simultaneously. Often, cDNA libraries representing expressed genes of an organism are available, along with expressed sequence tags (ESTs). ESTs are widely used as the probes for microarrays. Designing custom microarrays, rich in genes relevant to the experimental objectives, requires selection of probes based on their sequence. We have designed a probe selection method, called GeneSieve, to select EST probes for custom microarrays. To assign annotations to the ESTs, we cluster them into contigs using PHRAP.
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47

Tjaden, Brian C. "Computational methods for transcription anlysis using oligonucleotide microarrays /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/6907.

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48

Bergemann, Tracy L. "Image analysis and signal extraction from cDNA microarrays /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/9603.

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49

LUCHI, MASSIMILIANO. "DESIGN AND DEVELOPMENT OF MICROARRAYS FOR FUNCTIONAL GENOMICS." Doctoral thesis, Università degli studi di Trieste, 2007. http://thesis2.sba.units.it/store/handle/item/12262.

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2005/2006<br>Sono stati eseguiti molti studi che esplorano le potenzialità offerte dalla Surface Plamson Resonace (SPR) quale possibile tecnica per lo sviluppo di biosensori per l'analisi degli acidi nucleici. Lo scopo di questo studio è pertanto quello di esplorare la possibilità di migliorare le performances dell'SPR tramite la fabbricazione di cristalli plasmonici, così da sviluppare un nuovo strumento per gli studi di genomica funzionale, tramite una nuova architettura biologica. Questo strumento potrà essere una possibile base per un nuovo tipo di piattaforma array per lo studio del DNA g
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Wang, Yanfei. "Fuzzy methods for analysis of microarrays and networks." Thesis, Queensland University of Technology, 2011. https://eprints.qut.edu.au/48175/1/Yanfei_Wang_Thesis.pdf.

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Bioinformatics involves analyses of biological data such as DNA sequences, microarrays and protein-protein interaction (PPI) networks. Its two main objectives are the identification of genes or proteins and the prediction of their functions. Biological data often contain uncertain and imprecise information. Fuzzy theory provides useful tools to deal with this type of information, hence has played an important role in analyses of biological data. In this thesis, we aim to develop some new fuzzy techniques and apply them on DNA microarrays and PPI networks. We will focus on three problems: (1) c
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