Bibliografías temáticas / Milk Protein Allergy

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Literatura académica sobre el tema "Milk Protein Allergy"

Autor: Grafiati
Publicado: 4 de junio de 2021
Última modificación: 1 de febrero de 2022

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Artículos de revistas sobre el tema "Milk Protein Allergy"

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Ewart, Fiona A. "Making Milk Less Allergenic". STEM Fellowship Journal 4, n.º 1 (1 de abril de 2018): 27–32. http://dx.doi.org/10.17975/sfj-2018-008.

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The formation of stable aggregates by food proteins is associated with allergenicity. In particular, amyloid formation by the fish allergen parvalbumin was recently shown to favor IgE binding and subsequent allergic recognition. Therefore, reducing amyloid content in an allergenic food might offer a direct way to make that food less likely to trigger an allergy. In this project, protein aggregation and amyloid formation were studied in milk using gel electrophoresis and fluorescence-based assays. The results suggested that ordinary pasteurized milk from the grocery store contained protein aggregates and specifically amyloid. Processing the milk as normally done during food preparation did not appreciably affect general aggregation or amyloid formation. However, the addition of some polyphenol-containing food products to the milk appeared to result in reduced amyloid levels. Moreover, cranberry juice also appeared to reduce amyloid formation by the milk protein casein. These results suggest that the addition of cranberry or other polyphenol-rich foods to milk products for young children may reduce the risk of milk allergy development by diminishing protein aggregation.
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Platonova, Natalia B. "Allergy to cow’s milk protein". Pediatrician (St. Petersburg) 7, n.º 3 (15 de septiembre de 2016): 153–56. http://dx.doi.org/10.17816/ped73153-156.

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The prevalence of allergic diseases is increasing year by year. Atopic dermatitis (AD) - the earliest clinical manifestation of atopy. By definition, atopic dermatitis is the allergic skin disease that occurs usually in early childhood in individuals with hereditary predisposition to atopic diseases having a chronic relapsing course, age characteristics of the location and morphology of the foci of inflammation, characterized by pruritus and caused hypersensitivity as to allergens, and to nonspecific irritants. Food and inhalant allergens play an important role in the formation of atopic dermatitis. The protein of cow’s milk is one of the first products to which developing sensitization. This is especially important for children in their first year of life. During this period neonatologists of the maternity hospital and precinct pediatricians are very important to assess the risk of a child’s food allergy and, if necessary, artificial feeding or supplementary feeding to recommend an artificial mixture, taking into account evaluation results. The proper purpose depends largely on whether the risk is realized or not, as well as the effectiveness of treatment in the presence of existing clinical manifestations, because a rational diet is the guiding principle of therapy of atopic dermatitis in infants. Unfortunately, precinct pediatricians do not always assess the situation correctly. The article gives a clinical case, an example of which analyzed the most typical errors made when bottle-fed infants with food allergy to cow’s milk protein.
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Solinas, C., M. Corpino, R. Maccioni y U. Pelosi. "Cow's milk protein allergy". Journal of Maternal-Fetal & Neonatal Medicine 23, sup3 (14 de septiembre de 2010): 76–79. http://dx.doi.org/10.3109/14767058.2010.512103.

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Dhesi, Amrit, Gillian Ashton, Maria Raptaki y Nick Makwana. "Cow's milk protein allergy". Paediatrics and Child Health 30, n.º 7 (julio de 2020): 255–60. http://dx.doi.org/10.1016/j.paed.2020.04.003.

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Mousan, Grace y Deepak Kamat. "Cow’s Milk Protein Allergy". Clinical Pediatrics 55, n.º 11 (31 de agosto de 2016): 1054–63. http://dx.doi.org/10.1177/0009922816664512.

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Brigstocke, Lisa. "Cow’s milk protein allergy". InnovAiT: Education and inspiration for general practice 8, n.º 5 (7 de abril de 2015): 261–65. http://dx.doi.org/10.1177/1755738015577803.

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Dekker, Pieter M., Sjef Boeren, Alet H. Wijga, Gerard H. Koppelman, Jacques J. M. Vervoort y Kasper A. Hettinga. "Maternal Allergy and the Presence of Nonhuman Proteinaceous Molecules in Human Milk". Nutrients 12, n.º 4 (22 de abril de 2020): 1169. http://dx.doi.org/10.3390/nu12041169.

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Human milk contains proteins and/or protein fragments that originate from nonhuman organisms. These proteinaceous molecules, of which the secretion might be related to the mother’s allergy status, could be involved in the development of the immune system of the infant. This may lead, for example, to sensitization or the induction of allergen-specific tolerance. The aim of this study was to investigate the relation between maternal allergy and the levels of nonhuman proteinaceous molecules in their milk. In this study, we analysed trypsin-digested human milk serum proteins of 10 allergic mothers and 10 nonallergic mothers. A search was carried out to identify peptide sequences originating from bovine or other allergenic proteins. Several methods were applied to confirm the identification of these sequences, and the differences between both groups were investigated. Out of the 78 identified nonhuman peptide sequences, 62 sequences matched Bos taurus proteins. Eight peptide sequences of bovine β -lactoglobulin had significantly higher levels in milk from allergic mothers than in milk from nonallergic mothers. Dietary bovine β -lactoglobulin may be absorbed through the intestinal barrier and secreted into human milk. This seems to be significantly higher in allergic mothers and might have consequences for the development of the immune system of their breastfed infant.
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Varlamov, E. E., T. S. Okuneva y A. N. Pampura. "The relationship between sensitization to allergens of cow’s and goat’s milk at children with atopic dermatitis". Russian Journal of Allergy 10, n.º 2 (15 de diciembre de 2013): 61–65. http://dx.doi.org/10.36691/rja641.

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Introduction. The main principle of treatment of cow’s milk allergy (CMA) is the elimination from the diet of cow’s milk. However recently has been discussing the possibility to substitute the cow’s milk with goat’s milk in children with allergy to cow s milk protein. Background. To determine the relationship between sensitization to cow’s milk specific allergens in goat’s milk sensitized children. Methods. The study included 88 children with suspected allergy to CMA. All patients underwent determination of specific IgE to allergen of cow’s and goat’s milk allergen (ImmunoCAP 100 Phadia AB). We identified 35 children with sensitization to cow’s milk and measured specific IgE to α-laktalbumin, β-lactoglobulin and casein. Results. Sensitization to goat’s milk was estimated in 83% of patients with sensitization to cow’s milk. There was a significant positive correlation between the concentration of specific IgE to goat’s milk allergen and specific IgE to the cow’s milk allergen (R=0,91, p=0,0000001), a-laktalbumin (R=0,76, p=0,000007), β-lactoglobulin (R=0,72, p=0,000038) and casein (R=0,91, p=0,0000001). Conclusion. Formulas based on goat milk can not be considered hypoallergenic for children allergic to cow’s milk. Crosssensitization is mediated mainly with sensitization to casein. Introduction of goat milk and its derivatives in the diet of a child with an allergy to cow’s milk can be proven only by the absence of clinically relevant sensitization to goat milk.
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Nazaruddin, Nazaruddin, Hamdani Budiman, Basri A. Gani, Subhaini Jakfar, M. Hasan y Muhammad Hanafiah. "PROFILE OF ALLERGY HYPERPLASMA PATHOLOGIC ANTIBODY AND IMMUNOGENIC CHARACTERISTIC". Jurnal Kedokteran Hewan - Indonesian Journal of Veterinary Sciences 11, n.º 1 (7 de abril de 2017): 35–38. http://dx.doi.org/10.21157/j.ked.hewan.v11i1.5299.

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The objective of this research was to determine the allergy hyperplasma pathologic antibody and to evaluate the immunogenic characteristics. Blood and serum were collected from human suffering rhinitis, skin, eye and asthma allergies. To obtain a cloned allergen plasma protein (protein allergen that had been induced with the serum from human with allergic rhinitis, skin, eye and asthma), the goat was used as an intermediate animal. Hematological analysis showed that the leukocyte cell such as neutrophil, lymphocyte, monocyte, and eosinophil increase in allergic-suffered human. The blood smear test exhibited that the mastocyte cell was dominant which contributes to allergy activities in human body. The sodium dodecyl sulphate-polyacrylimide gel electrophoresis (SDS-PAGE) assay detected protein allergens with molecular weight of 188 kDa (IgE) and 60-62 kDa (mastocyte cell). The reactivity assay using enzyme linked immunosorbent-assay (ELISA) revealed that cloned-allergens (whole hyperplasma allergen from goat isolates) express the best reactivity at various concentrations of IgE than the leukocyte cells. This research concluded that the clones of protein allergen have better immunogenic characteristic and those proteins can be recommended as the candidate of allergen to induce the humoral immunity on host and deliver specific product of anti-allergy such as milk.
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Hodgkinson, Alison J., Natalie A. McDonald y Brad Hine. "Effect of raw milk on allergic responses in a murine model of gastrointestinal allergy". British Journal of Nutrition 112, n.º 3 (29 de mayo de 2014): 390–97. http://dx.doi.org/10.1017/s0007114514001044.

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Epidemiological studies have shown an association between the consumption of raw farm milk and reduced incidence of allergy. In the present study, we fed untreated raw milk, gamma-sterilised milk, heat-treated milk or water to mice and compared their responses to allergen exposure and challenge treatment in a mouse model of gastrointestinal allergy. From weaning (3 weeks old), groups of BALB/c female mice (n8) received raw milk, gamma-sterilised milk, heated milk or water via drink bottles, with the control group receiving water. All mice were fed a standard (dairy protein-free) rodent diet. At 6 and 8 weeks, groups were given intra-peritoneal injections with ovalbumin (OVA)/alum to sensitise them to the antigen. Controls were sham immunised. At week 10, mice were fasted and challenged four times on alternate days by intra-gastric administration with 50 mg OVA or saline. Levels of bacteria and milk proteins were assessed in milk samples. Mouse serum levels of specific IgE, IgG1and IgG2aantibodies and mouse mast cell protease-1 (MMCP-1) were determined. Cytokine responses to 48 h activation with OVA were measured in cultured splenocytes from mice. Sterilised and heated milks contained no viable bacteria and reduced detectable levels of many milk proteins, in contrast to raw milk. Mice drinking raw milk had highest serum MMCP-1 and specific-OVA IgE responses. Cultured splenocytes from OVA-primed mice produced similar levels of IL-4 in response to the antigen; however, IL-10 levels were highest from mice drinking raw milk. Overall, the present study adds to the evidence that consuming different types of milk can affect allergic responses to a non-related dietary antigen.
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Tesis sobre el tema "Milk Protein Allergy"

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Malapit, Monica y Evan Mallory. "In vitro aerodynamic analysis of co-spray dried fluticasone propionate (FP) and salmeterol xinafoate (SX) dry powder inhalation aerosols with lactose-alternative excipient". The University of Arizona, 2017. http://hdl.handle.net/10150/624206.

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Class of 2017 Abstract
Objectives: Milk protein allergy is estimated to affect 1.2% to as much as 17% of people of all ages. Advair® Diskus® (FP/SX) utilizes lactose as an excipient which limits the utility of this product for this population. Furthermore, Advair® Diskus® is formulated as an interactive physical mixture via a micronization process. Alternatively, spray dried engineering achieves narrow particle size distribution, allowing greater deposition in the targeted respiratory bronchioles. The purpose of this dry powder inhaler (DPI) study was to conduct an in vitro comparative analysis of the aerodynamic performance of a co-spray dried lactose-free formulation of FP/SX with a mannitol excipient as a molecular mixture versus the Advair® Diskus® 250/50 (FP/SX) interactive physical mixture product. Methods: Utilizing mannitol as an excipient, a co-spray dried FP/SX powder was prepared using the Buchi Mini-Spray Dryer B-290 under closed system configuration. The resulting feed solution was spray dried at pump rates of 25%, 50%, and 100% with all other parameters remaining constant (aspiration, atomization rate, nitrogen gas rate). The primary outcome measure, aerodynamic performance, was assessed using the Copley Next-Generation Impactor (NGI). NGI data for the DPIs was used to calculate mass median aerodynamic diameter (MMAD), geometric standard deviation (GSD), and fine particle fraction (FPF) of each powder, including the Advair® Diskus®. Residual water content was quantified by Karl Fischer titration. Particle characteristics were visualized by scanning electron microscopy. Results: FPF, MMAD, and GSD were calculated from NGI data; Wolfram Alpha software was used to calculate MMAD and GSD. T-test regression was used for comparative analysis of spray-dried and Advair® Diskus® powders. MMAD for each spray dried sample was analyzed using a t-test regression against the MMAD values from the Advair® Diskus®. Using aerodynamic analysis studies triplicated for each powder, there was no significant difference between the spray dried powder and Advair® Diskus® for MMAD and GSD (p-values >0.05). The 50% and 100% pump rate samples had similar FPF to the Advair® Diskus® (p-values >0.05). However, the 25% pump rate sample had a significantly improved FPF compared to the Advair® Diskus® (p <0.01). Conclusions: A co-spray-dried lactose-free formulation of FP/SX with a mannitol excipient demonstrated similar aerodynamic performance to the Advair® Diskus® which consists of a physical mixture of two drugs with lactose. Of significance, 25% pump rate spray-dry conditions demonstrated an improved FPF compared to the Advair® Diskus®.
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2

Edqvist, Jenny y Mariam Hassan. "Protein and Energy Intake in Children with Cow’s Milk Protein Allergy : The results of three-day estimated food records in Swedish children 2-11 years of age compared to control group". Thesis, Uppsala universitet, Institutionen för kostvetenskap, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-222228.

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Background: Cow’s Milk Protein Allergy (CMA) is one of the most common food allergies among young children. There is no effective treatment for CMA aside from elimination diets, which increase the risk for malnutrition. Proper nutritional counseling on a regular basis is recommended for children with CMA in order to guarantee an adequate dietary intake. Objective: The purpose of this study was to estimate the energy and protein intake among Swedish children 2-11 years of age with CMA and compare it with control group of children with no food allergies as well as with dietary recommendations. Method: Families who were interested in participating in this study (n=20) were asked to fill in a three-day estimated food record as well as answer a questionnaire. Results: Results show that the average daily intake of energy and protein in children 2-11 years with CMA was almost 10% lower compared to non-allergic children of the same age. The estimated energy intake in both groups was close to the daily requirements of the Nordic Nutrition Recommendations (NNR), as opposed to that by the America Academy of Pediatrics (AAP). The estimated protein intake in both groups was higher than the NNR and WHO daily recommendations per kg/day. The questionnaire shows that 60% of families of children with CMA have previously received nutritional support from a clinical dietitian. Most families of allergic children choose either soya-based or oat-based products as alternatives to milk, all of which contain less protein than milk. While none of the children in both groups reached the recommended daily intake for calcium, only 30% of children with CMA took calcium supplements. None of the children in both groups reached the recommended daily intake for vitamin D. Conclusion: Results of this study suggests an increased need for nutritional guidance by a clinical dietitian on a regular basis among children aged 2-11 years with CMA, as these children were found to have almost 10% lower average daily intake of both energy and protein than non-allergic children of the same age. Alternatives to milk used among families of children with CMA contain less protein than milk. Low calcium intake among children with CMA suggests a need for calcium supplements among all children with CMA. Vitamin D intake was low among all children in this study.
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Veríssimo, Daniela Maria Maia [UNESP]. "Um estudo sobre a ambivalência materna em mães de crianças com alergia à proteína do leite de vaca". Universidade Estadual Paulista (UNESP), 2009. http://hdl.handle.net/11449/97559.

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Made available in DSpace on 2014-06-11T19:29:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-12-04Bitstream added on 2014-06-13T19:58:28Z : No. of bitstreams: 1 verissimo_dmm_me_assis.pdf: 445435 bytes, checksum: 93b36ce929159ed46a80e679738d150a (MD5)
A maternidade é conhecida como um momento sublime na vida da mulher, mesmo em meio às transformações ocorridas no mundo contemporâneo, essa visão idealizada da maternidade é composta de fatores: sociais, culturais e históricos. A psicanálise também contribuiu na construção desta visão, tanto para uma responsabilização das mães pela estruturação psíquica das crianças, quanto para a naturalização da maternidade caracterizado-a como própria da feminilidade. Porém, inúmeros autores apontam para as dificuldades e pressões vivenciadas pelas mães da gestação ao pós-parto na relação com seu bebê, pois a vivência da maternidade sempre vem acompanhada de sentimentos conflitantes, ou seja, ambivalências. A literatura aponta também que a ambivalência se torna mais intensa quando o encontro com o bebê real é marcado por uma doença. No caso do presente trabalho, estudamos os efeitos da alergia à proteína do leite de vaca (APLV), na relação mãe-bebê, uma vez que essa doença, que vem ganhando importância no contexto pediátrico, apresenta uma particularidade: ao atingir o bebê em aleitamento, quem realiza uma dieta livre de qualquer produto lácteo é a mãe; devido à essa particularidade acreditamos que essa doença ao atingir bebês cria uma condição especial ao desenvolvimento da relação mãe-bebê. Com o objetivo de compreender as manifestações do sentimento de ambivalência em mães de bebês com a referida alergia realizamos uma investigação qualitativa psicanalítica, tendo como ponto de partida um estudo sobre os cuidados maternos ao longo da história, seguido de revisão...
Motherhood is known as a sublime moment in the life of a woman, even with the changes in the contemporary world, this idealized vision of motherhood is composed by some factors: social, cultural and historical. Psychoanalysis has also contributed in building this vision, not only the responsibility of these mothers for the psychic structure of these children, but also for the naturalization of motherhood characterized it as their own femininity. However, many authors pointed out the difficulties and pressures experienced by the these mothers from pregnancy to post partum relate to their babies, because the experience of motherhood always comes along with a conflicted feelings, and this is called ambivalence. The literature also indicates that ambivalence becomes more intense when the encounter with the real baby is marked by a disease. In the present work, we studied the effects of allergy to the protein in cow's milk (APLV) in mother-infant relationship, once that this disease which has become importance in the pediatric context ,it shows an particularity: when it get to the baby who is breastfeeding, who carries on a free diet of any dairy product is the mother because of this particularity we believe that whenever this disease reaches the baby it creates a special condition between the development of mother-infant relationship. In order to understand the manifestations of ambivalence feelings in mothers who have allergic babies , we carried out a qualitative investigation of psychoanalysis, and as a starting... (Complete abstract click electronic access below)
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Veríssimo, Daniela Maria Maia. "Um estudo sobre a ambivalência materna em mães de crianças com alergia à proteína do leite de vaca /". Assis : [s.n.], 2009. http://hdl.handle.net/11449/97559.

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Orientador: Jorge Luís Ferreira Abrão
Banca: Inês Amosso Dolci
Banca: Diana Pancini de Sá Antunes Ribeiro
Resumo: A maternidade é conhecida como um momento sublime na vida da mulher, mesmo em meio às transformações ocorridas no mundo contemporâneo, essa visão idealizada da maternidade é composta de fatores: sociais, culturais e históricos. A psicanálise também contribuiu na construção desta visão, tanto para uma responsabilização das mães pela estruturação psíquica das crianças, quanto para a naturalização da maternidade caracterizado-a como própria da feminilidade. Porém, inúmeros autores apontam para as dificuldades e pressões vivenciadas pelas mães da gestação ao pós-parto na relação com seu bebê, pois a vivência da maternidade sempre vem acompanhada de sentimentos conflitantes, ou seja, ambivalências. A literatura aponta também que a ambivalência se torna mais intensa quando o encontro com o bebê real é marcado por uma doença. No caso do presente trabalho, estudamos os efeitos da alergia à proteína do leite de vaca (APLV), na relação mãe-bebê, uma vez que essa doença, que vem ganhando importância no contexto pediátrico, apresenta uma particularidade: ao atingir o bebê em aleitamento, quem realiza uma dieta livre de qualquer produto lácteo é a mãe; devido à essa particularidade acreditamos que essa doença ao atingir bebês cria uma condição especial ao desenvolvimento da relação mãe-bebê. Com o objetivo de compreender as manifestações do sentimento de ambivalência em mães de bebês com a referida alergia realizamos uma investigação qualitativa psicanalítica, tendo como ponto de partida um estudo sobre os cuidados maternos ao longo da história, seguido de revisão... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Motherhood is known as a sublime moment in the life of a woman, even with the changes in the contemporary world, this idealized vision of motherhood is composed by some factors: social, cultural and historical. Psychoanalysis has also contributed in building this vision, not only the responsibility of these mothers for the psychic structure of these children, but also for the naturalization of motherhood characterized it as their own femininity. However, many authors pointed out the difficulties and pressures experienced by the these mothers from pregnancy to post partum relate to their babies, because the experience of motherhood always comes along with a conflicted feelings, and this is called ambivalence. The literature also indicates that ambivalence becomes more intense when the encounter with the real baby is marked by a disease. In the present work, we studied the effects of allergy to the protein in cow's milk (APLV) in mother-infant relationship, once that this disease which has become importance in the pediatric context ,it shows an particularity: when it get to the baby who is breastfeeding, who carries on a free diet of any dairy product is the mother because of this particularity we believe that whenever this disease reaches the baby it creates a special condition between the development of mother-infant relationship. In order to understand the manifestations of ambivalence feelings in mothers who have allergic babies , we carried out a qualitative investigation of psychoanalysis, and as a starting... (Complete abstract click electronic access below)
Mestre
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5

Akita, Emmanuel E. "Lipophilization of beta-lactoglobulin : effect on hydrophobicity, surface functional properties, digestibility and allergenicity". Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/27789.

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In this research, beta-lactoglobulin was chemically modified by attaching different levels of stearic acid to the protein. The effect of this modification on hydrophobic!ty, emulsifying and foam properties, digestibility and allergenicity of the protein was investigated. It was found that the effect of fatty acid attachment or lipophilization depended on the amount of fatty acids attached to the protein. Incorporation of the hydrophobic ligands led to increased hydrophobic interactions, resulting in a decreasing solubility with extent of incorporation. Furthermore, the surface hydrophobicity measurements showed that the two fluorescence probes 8-anilinonaphthalene-l-sulfonate (ANS) and cis-parinaric acid (CPA) used for the surface hydrophobicity measurements were not equivalent This may support the. observation by earlier workers that ANS measures aromatic hydrophobicity and CPA aliphatic hydrophobicity. The studies on surface functional properties i.e. emulsifying and foaming properties, indicated that there was some improvement in these functional properties at low and medium levels of incorporation which decreased as the extent of fatty acid attachment further increased. The improvement, of these functional properties could be attributed to improved amphiphilicity of the proteins at these levels of incorporation. This research also showed that both high solubility and high ANS surface hydrophobicity is needed for the best emulsifying properties. In vitro digestibility studies showed a decrease in digestibility of the modified proteins with increased lipophilization. From the passive cutaneous anaphylaxis experiments, it was found that the level of fatty acid attachment to the protein had a significant effect on its ability to elicit IgE antibodies. Increased ability to elicit IgE antibodies was observed at a low level of fatty acid. When a medium level of fatty acid was attached the ability to elicit antibodies was reduced and almost completely destroyed when a higher level of fatty acid was incorporated. The above observations could be explained by the fact that the low level incorporation of fatty acid led to changes in the protein structure which exposed more allergenic sites. The almost complete destruction of the allergenicity could be attributed to denaturation of the protein which reduced or destroyed available allergenic sites. The antigenicity or binding of the modified proteins to the IgG antibodies raised against the native protein was studied by both direct and competitive enzyme linked immunosorbent assay. It was found that at low and medium levels of incorporation, the proteins demonstrated increased binding ability compared to the native protein. This was attributed to the increased exposure of antigenic sites on the protein with fatty acid incorporation. However, the protein with high level of incorporated fatty acid showed decreased binding ability.
Land and Food Systems, Faculty of
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Tammineedi, Chatrapati Veera Raghava Kumar. "EFFECT OF UV-C LIGHT, HIGH INTENSITY ULTRASOUND AND NONTHERMAL ATMOSPHERIC PLASMA TREATMENTS ON THE ALLERGENICITY OF MAJOR COW MILK PROTEINS". OpenSIUC, 2012. https://opensiuc.lib.siu.edu/theses/921.

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Milk is one of the eight major food allergens. Cow's milk allergy is the most common allergy in children under 2 years of age. About 1.6 to 2.8 percent of children under this age are reported to have cow's milk allergy. Casein, β-lactoglobulin and α-lactalbumin are major milk protein allergens. Nonthermal treatments like high intensity ultrasound, ultraviolet (UV) light and nonthermal plasma treatments have been reported in the literature to be effective in reducing the allergenicity of different food proteins. Hence it was expected for these treatments to reduce cow milk allergenicity. The objective of this study was to investigate the effect of high intensity ultrasound, nonthermal atmospheric plasma and UV-C light treatments in reducing the allergenicity of isolated major milk proteins. Sonics Vibracell VC 505 ultrasonic liquid processor was used to perform high intensity ultrasound treatments. UV light treatments were performed using a DDK Scientific Corporation UV tunnel. A nonthermal atmospheric plasma setup assembled in Department of Microbiology lab was used to perform plasma treatments. Samples were analyzed using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) to estimate the change in protein concentration and enzyme linked immuno sorbent assays (ELISA) to observe the change in IgE binding. A one-way analysis of variance was conducted to evaluate the relationship between treatment time and percent IgE binding at 95% confidence level. Further investigation was conducted with nuclear magnetic resonance (NMR) spectroscopy on treated casein to assess any change in the structure of protein. SDS-PAGE results for ultrasound and plasma treatments didn't show any change in gel band intensities for casein, β-lactoglobulin and α-lactalbumin indicating no significant change in protein concentration. Ci-ELISA analysis showed that there was no significant difference (p>0.05) in IgE binding values for control and treated samples in ultrasound and plasma treatment conditions tested in this study. The intensities of all the three protein bands in SDS-PAGE gel were reduced by UV-C light treatment at 15 min treatment time. In Ci-ELISA, there was a significant difference (p< 0.05) in IgE binding values for control and treated samples and a reduction in allergenicity of proteins (25% reduction for casein and 28% reduction for whey protein fractions) was observed. Further investigations using in vivo clinical trials need to be conducted to confirm this result. NMR results didn't show any noticeable changes in the structures of casein with all three different treatments. In conclusion, UV-C light treatment can reduce the allergenicity of isolated major milk proteins to some extent. High intensity ultrasound and nonthermal atmospheric plasma treatments failed to generate effective results for reducing allergenicity at the conditions tested in this study. Higher intensity and longer treatment conditions might yield better results with ultrasound treatment. Different power and gas flow rates used to generate plasma with direct exposure of proteins might yield better results towards reducing the allergenicity of major milk allergens.
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Crowley, Elesa. "The role of cow's milk protein in children with chronic functional constipation". 2009. http://hdl.handle.net/1959.13/39520.

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Masters Research - Masters of Medical Science
The goal of this thesis is to report on research that explored the role of cow’s milk protein in children with chronic functional constipation. The research consisted of a systematic review of the literature, two clinical crossover trials, and a qualitative exploration of the lived experience of following a milk-free diet. Chapter 1 provides the introduction to both allergy and constipation, and the relationship between the two. Causes of constipation can be organic or functional (1). Organic causes of constipation occur in relation to a primary disease classification such as endocrine or metabolic disorders, neurologic disorders, anatomic malformation, collagen vascular disease and some drugs (for example, opiates). Chronic functional constipation is defined as having one bowel motion every three to 15 days (2) and is characterised by painful bowel movements or strain in defecation, hard stools with increased diameter or pellets, and occurs with or without soiling (3). This functional constipation is defined as chronic when it persists for greater than two weeks (4). Chapter 2 details the methods used in searching the literature for evidence for a role of cow’s milk consumption in chronic functional constipation in children from 1980 to 2006. This was published as a systematic review. The literature surrounding cow’s milk and constipation was found to be limited. None of the studies previously conducted were population-based or structured to provide evidence-based evaluation or treatment guidelines at either the general practitioner or paediatric specialist level. The strongest evidence found was a double blind randomised control trial conducted by Iacono and colleagues (3). The research study by Iacono and colleagues (3) provides evidence of an association between cow’s milk and constipation. The following research questions were developed from the systematic review: 1. Can the results of the Iacono and colleagues study of children with chronic functional constipation that respond to the replacement of cow’s milk protein with soy be replicated in the Australian setting? 2. Does cow’s milk β casein A1 cause constipation in children with chronic functional constipation? 3. What are the immunological and biochemical mechanisms underlying chronic functional constipation that respond to the removal of cow’s milk protein in children? 4. What factors affect the feasibility of parents administering a cow’s milk protein free diet to their children? The four questions were addressed by two different dietary crossover trials and a qualitative study. Chapter 3 describes the participants recruited and the methods used for the crossover trials investigating milk protein and paediatric chronic functional constipation including details of the primary outcome measure (number of bowel motions during a two-week trial period) and secondary outcome measures (biochemical, immunological and faecal analysis). Chapter 4 describes the results of Trial 1, which replicated the Iacono and colleagues study in the Australian setting, investigating the effects of soy and cow’s milk β-casein A1 in children with chronic functional constipation. One hundred percent of participants experienced resolution of their constipation during the soy milk condition compared with 68% experiencing resolution during the soy milk condition in the Iacono and colleagues study (n=65). Thirteen participants were recruited to Trial 1. Nine participants returned constipation diaries for the study period. The mean (SD) number of stools for each of the conditions was: baseline, 5.1 (1.4); cow’s milk 9.9 (4.4); washout 13.0 (5.2); and soy milk 15.1 (5.0). The differences between the three dietary conditions were statistically significant, p=0.03. The results confirmed the hypothesis that children in the Australian setting with chronic functional constipation unresponsive to the usual treatments, respond to the removal of cow’s milk protein from the diet. Chapter 5 describes the results of Trial 2, the double blind crossover trial comparing the effects of cow’s milk β-casein A1 and cow’s milk β-casein A2 in children with chronic functional constipation. Thirty-nine participants were recruited to Trial 2 and 26 participants returned constipation diaries for the trial period. Unlike the soy result, the cow’s milk β casein A2 did not give 100% resolution of constipation, in fact, the percentage resolution was almost identical to the cow’s milk β casein A1 result. The fact that some children responded during the cow’s milk casein A1 condition in both trials could be caused by a threshold effect, given it was likely that participants were consuming less cow’s milk protein during the trial (400 mL with elimination of all other sources of cow’s milk protein) than on their pre-trial diet. Resolution with both the cow’s milk β casein A1 and cow’s milk β casein A2 conditions suggests that these children are able to tolerate some cow’s milk protein before the symptom of constipation occurs. This could be a food intolerance type reaction or there is some other component in cow’s milk that is causing the problem in these children. Chapter 6 describes a qualitative study of the feasibility for mothers to administer a cow’s milk protein free diet to their children. The experiences of mothers following a cow’s milk protein free diet to assist in the management of chronic functional constipation in children were reported. A number of themes were identified that are useful to health professionals educating families. Mothers found the removal of cow’s milk protein from the diets of their children challenging but persevered due to the potential benefit to their children. Many mothers planned to continue post study with a modified approach to the cow’s milk protein free diet by allowing some cow’s milk protein in the diet to make the diet more acceptable to the family but not as much as the pre-trial diet. These experiences provide health professionals with valuable insights and ideas to assist their patients to manage a cow’s milk protein free diet. Chapter 7 discusses all aspects of the research including any limitations. The results of Trial 1 confirmed the hypothesis that children in the Australian settling with chronic functional constipation unresponsive to the usual treatments respond to the removal of cow’s milk protein from the diet. Therefore, cow’s milk protein is involved in the aetiology of constipation in these children. All the study participants demonstrated an absence or low level of normal gut flora, which may affect bowel regularity. Further research into species present and absent may provide further explanations to the lack of bowel regularity in these children. The immunological and biochemical mechanisms underlying chronic functional constipation that respond to the removal of cow’s milk protein requires further investigation. Although the number of statistically significant variables between the conditions was low, there was a high degree of abnormality. Further investigations are needed, including research into food intolerance reactions that affect the nerve endings in the bowel. The results in Trial 1 and Trial 2 are suggestive of an involvement of blood factors including platelets and monocytes. Other children may have a chronic Streptococcus A infection which may be contributing to constipation as well as to liver function abnormalities. Liver function abnormalities were observed for some participants in both trials, independent of milk condition. The extent to which the research questions have been answered is evaluated in Chapter 7, which includes the conclusions and recommendations of this research. In brief, the findings were: • Children with chronic functional constipation that is unresponsive to the traditional treatments should trial a cow’s milk protein free diet for at least two weeks to determine whether this may resolve the constipation. During this period, the numbers and form of bowel motions should be recorded and results compared to a one week record collected prior to commencing the cow’s milk protein free diet. • Due to the complicated nature of a cow’s milk protein free diet, especially the number of processed foods which contain hidden cow’s milk protein, consultation with a dietitian is essential for implementation of this diet. The dietitian should consider educating the patient’s family, both parents and siblings, to ensure the best outcome in terms of acceptance and compliance of the diet, and provide adequate resources. • If this dietary modification is successful for the child and alleviates constipation, consultation with a dietitian is recommended to determine the amount tolerated and nutritional adequacy of the diet. Soy milk is recommended as a substitute for cow’s milk and a probiotic needs to be prescribed to assist with the normalisation of gut flora. • Education of health professionals such as general practitioners, paediatricians, and paediatric continence nurses, regarding a cow’s milk protein free diet for chronic functional constipation, is essential to support the child and his/her family and integral to the success of this strategy. The findings of this research will be published in the scientific literature and as conference presentations. It is hoped that these findings will assist in the management of children with chronic functional constipation unresponsive to the traditional treatments.
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Češková, Blanka. "Potravinové alergie a intolerance - fakta a mýty". Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-364281.

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Food-related diseases, including food allergies and food intolerances, are on the rise worldwide. According to the World Health Organisation (WHO), allergic diseases in the economically advanced countries of the WHO have become the largest child environmental epidemic. Dysregulation of immune tolerance is the basic mechanism involved in the development of food allergy. It is believed that the risk of developing allergies is more related to other lifestyle factors such as a diet, physical activity or obesity. Food allergies in children and adult populations vary both in the spectrum of triggering foods and also their symptoms and their severity. The prognosis also differs in allergies for different types of foods. One of the most important factors affecting the correct development of the baby's immune system is nutrition. In the first 4 - 6 months, the baby should only receive breast milk - for infants it is the most appropriate and allergenically safe diet. It strengthens their immune system. Its positive effect is observed especially on the occurrence of food allergies and atopic eczema. However, developing asthma and other allergies may not be prevented. Breastfeeding has an extraordinary importance and benefits in preventing many illnesses for both the child and the mother. Milk is a major food...
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Weidenthalerová, Edita. "Hodnocení celkového nutričního stavu a klinických projevů u kojenců s alergickou kolitidou". Master's thesis, 2020. http://www.nusl.cz/ntk/nusl-437554.

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This diploma thesis deals with the evaluation of clinical manifestations in infants with allergic colitis and their overall nutritional status, anthropometry, blood count and antibodies against cow's milk proteins. Allergic colitis is one of the most common manifestations of infant allergy to cow`s milk protein with gastrointestinal involvement. The theoretical part summarizes the anthropometric evaluation of growth and development, infant nutrition, the most important laboratory indicators of nutritional status. The part is generally devoted to food allergies, mainly allergy to cow's milk protein. The practical part deals with the evaluation of a sample of examined patients in gastroenterology outpatient clinics and nutritional outpatient clinic of the Department of Pediatrics and Adolescent Medicine of the 1st Faculty of Medicine, Charles University and General Hospital in Prague. The observed group of infants with allergic colitis includes infants exclusively breastfed, breastfed by a mother following a non-dairy diet, infants on an extensive hydrolyzate or on an amino acid formula. The main goal of the diploma thesis was to trace the most common clinical manifestations and whether there are any changes in their nutritional status during the disease and its treatment. A total of 45 randomly...
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Oliveira, José Carlos Abreu. "Alergia à proteína do leite de vaca - diagnóstico e intervenção". Master's thesis, 2020. http://hdl.handle.net/10284/9304.

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As alergias alimentares são, hoje em dia, um crescente motivo de preocupação, pois estão cada vez mais presentes no nosso quotidiano e expressam-se cada vez com mais frequência. Apesar de se manifestarem em diversas faixas etárias, tem-se verificado uma maior incidência na população infantil, desde o nascimento. O leite de vaca, sendo um dos alimentos mais utilizados na dieta humana, é dos que apresenta um potencial alergénico maior devido à presença de β-lactoglobulina, proteína esta diferente da caseína presente no leite materno. Atingindo cerca de 6% da população infantil, a alergia à proteína do leite de vaca, que pode manifestar-se ainda no primeiro ano de vida, é já considerada uma doença de infância. Sendo precocemente identificada e controlada, a alergia não acarreta consequências para o desenvolvimento saudável da criança. A alergia manifesta-se maioritariamente por sintomas gastrointestinais e cutâneos, sendo que pode afetar as vias respiratórias com mais intensidade nos primeiros episódios alérgicos. O desenvolvimento de alergia á proteína do leite de vaca pode ser influenciado por diversos fatores, sendo um deles a genética familiar, o historial de alergias alimentares ou respiratórias, atopias de pele, entre outras. Manter o aleitamento materno entre os 4 e os 6 meses de vida pode ajudar a prevenir o seu desenvolvimento. Quando existem impedimentos a essa medida, recomenda-se a utilização de fórmulas extensamente hidrolisadas ou hipoalergénicas. Sendo uma patologia há muito descrita, até à presente data, poucos são os estudos ou conclusões, não se encontrando ainda disponível uma cura para a alergia à proteína do leite de vaca. Existem tratamentos e medidas a adotar que melhoram a qualidade de vida das pessoas afetadas, tais como fórmulas de substituição, dietas de eliminação, tratamentos de emergência ou controlo de sintomas. Estima-se que 80% das crianças recuperem e/ou adquiram tolerância até ao terceiro ano de vida.
Food allergies are now a growing concern, as they are increasingly present in our daily lives and are expressed more and more frequently. Although they occur in several age groups, there has been a higher incidence in the child population since birth. Cow's milk, being one of the foods most used in the human diet, has the highest allergenic potential due to the presence of β-lactoglobulin, a protein that is different from the casein present in breast milk. Reaching about 6% of the child population, allergy to cow's milk protein, which may occur even before the first year of life, is already considered a childhood disease. Being early identified and controlled, allergy does not have consequences for the healthy development of the child. The allergy is manifested mainly by gastrointestinal and cutaneous symptoms, and it can affect the airways with more intensity in the first allergic episodes. The development of allergy to cow's milk protein can be influenced by several factors: family genetics (a history of food or respiratory allergies, skin atopy, among others). Maintaining breastfeeding between 4 and 6 months of age can help prevent their development. Where there are impediments to this measure, it is recommended to use extensively hydrolyzed or hypoallergenic formulas. Being a pathology long described but to date without many studies or conclusions, a cure for APLV has not yet been described. There are treatments and measures to be adopted that improve the quality of life of the affected people, such as substitution formulas, elimination diets, emergency treatments or symptom control. It is estimated that 80% of children recover and/or acquire tolerance by the third year of life.
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Libros sobre el tema "Milk Protein Allergy"

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Puntis, John. Food allergy. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198759928.003.0019.

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Food allergy is an immune response to food that can be classified as immunoglobulin (Ig)-E and non-IgE mediated. Milk, egg, peanut, tree nuts, and fish are among the most prevalent causes of food allergy. Mild reactions can include itchy rash, watering eyes, and nasal congestion while a severe reaction results in anaphylaxis. A detailed clinical history is essential when making a diagnosis, and skin prick testing and quantitative measurement of food-specific IgE antibodies can be helpful. Cow milk protein allergy causes a plethora of symptoms and frequently resolves spontaneously over the first 2 years of life; diagnosis is based mainly on clinical history. Food challenges have a pivotal role in the diagnosis of food allergy. Introduction of ‘allergic’ foods at 3–6 months alongside continuing breastfeeding may prevent allergy.
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1934-, Bellanti Joseph A., ed. Cow's milk protein sensitivity in infants: Symposium proceedings, December 2-4, 1988, Dorado, Puerto Rico. Princeton: Excerpta Medica, 1989.

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Hamburger, Robert N. Food intolerance in infancy: Allergology, immunology, and gastroenterology. Raven Pr, 1989.

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Capítulos de libros sobre el tema "Milk Protein Allergy"

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Downs, Melanie L., Jamie L. Kabourek, Joseph L. Baumert y Steve L. Taylor. "Milk Protein Allergy". En Milk and Dairy Products in Human Nutrition, 111–28. Oxford: John Wiley & Sons, 2013. http://dx.doi.org/10.1002/9781118534168.ch6.

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Ferguson, A. y K. C. Watret. "Milk Protein Allergy: Clinical Features, Pathogenesis, and Therapeutic Implications". En Milk Proteins, 261–69. Heidelberg: Steinkopff, 1989. http://dx.doi.org/10.1007/978-3-642-85373-9_42.

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Dupont, Christophe. "Cow’s Milk Allergy: Protein Hydrolysates or Amino Acid Formula?" En Pharma-Nutrition, 359–71. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-06151-1_18.

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Saarinen, K. M., K. Juntunen-Backman, A.-L. Järvenpää, P. Klemetti, P. Kuitunen, L. Lope, M. Renlund, M. Siivola, O. Vaarala y E. Savilahti. "Breast-Feeding and the Development of Cows’ Milk Protein Allergy". En Advances in Experimental Medicine and Biology, 121–30. Boston, MA: Springer US, 2002. http://dx.doi.org/10.1007/0-306-46830-1_10.

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Keller, Klaus M., Annemarie Bürgin-Wolff, Hartmut Menger, Rainer Lippold, Stefan Wirth y Walter Baumann. "IgG, IgA, and IgE Antibodies to Cow Milk Proteins in an Allergy Prevention Study". En Advances in Experimental Medicine and Biology, 467–73. Boston, MA: Springer US, 1991. http://dx.doi.org/10.1007/978-1-4615-3838-7_60.

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Elagamy, E. I. "Milk Protein Allergy". En Reference Module in Food Science. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-08-100596-5.00971-9.

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El-Agamy, El-Sayed I. "Milk Protein Allergy". En Reference Module in Food Science. Elsevier, 2020. http://dx.doi.org/10.1016/b978-0-12-818766-1.00112-4.

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Furuta, Glenn T. "Cow Milk Protein Allergy". En Encyclopedia of Gastroenterology, 506–8. Elsevier, 2004. http://dx.doi.org/10.1016/b0-12-386860-2/00483-4.

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Mehta, Poonam. "Cow Milk Protein Allergy". En Case Based Reviews in Pediatric Pulmonology, 204. Jaypee Brothers Medical Publishers (P) Ltd., 2018. http://dx.doi.org/10.5005/jp/books/13112_33.

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da Silva, Paulo H. F., Vanísia C. D. Oliveira y Luana M. Perin. "Cow’s Milk Protein Allergy and Lactose Intolerance". En Raw Milk, 295–309. Elsevier, 2019. http://dx.doi.org/10.1016/b978-0-12-810530-6.00014-6.

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Actas de conferencias sobre el tema "Milk Protein Allergy"

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Polidori, Paolo y Silvia Vincenzetti. "Use of Donkey Milk in Children with Cow\'s Milk Protein Allergy". En Foods: Bioactives, Processing, Quality and Nutrition. Basel, Switzerland: MDPI, 2013. http://dx.doi.org/10.3390/bpqn2013-01162.

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Lendvai-Emmert, Dominika, Vanessza Emmert, Katalin Fusz, Viktória Prémusz, Viktória Németh y Gergely Tóth. "GP181 Comparing diagnostic tests in children with cow’s milk protein allergy". En Faculty of Paediatrics of the Royal College of Physicians of Ireland, 9th Europaediatrics Congress, 13–15 June, Dublin, Ireland 2019. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2019. http://dx.doi.org/10.1136/archdischild-2019-epa.242.

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novikova, valeria, Natalya Bogdanova, Natalya Prokopyeva, Sergey Lapin, Daria Kuznetsova y Pavel Vorontsov. "P11 Secondary lactose intolerance and cow’s milk protein allergy in infants". En Faculty of Paediatrics of the Royal College of Physicians of Ireland, 9th Europaediatrics Congress, 13–15 June, Dublin, Ireland 2019. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2019. http://dx.doi.org/10.1136/archdischild-2019-epa.367.

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Spatariu, Luminita, Florentina Borozan y Doina Anca Plesca. "P170 The phenotype of the patient with cow’s milk protein allergy". En 8th Europaediatrics Congress jointly held with, The 13th National Congress of Romanian Pediatrics Society, 7–10 June 2017, Palace of Parliament, Romania, Paediatrics building bridges across Europe. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2017. http://dx.doi.org/10.1136/archdischild-2017-313273.258.

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Lendvai-Emmert, Dominika, Vanessza Emmert, Katalin Fusz, Viktória Prémusz y Gergely Tóth. "P319 The unexpected ‘troublemaker’ – Behavioural changes in children with cow’s milk protein allergy". En Faculty of Paediatrics of the Royal College of Physicians of Ireland, 9th Europaediatrics Congress, 13–15 June, Dublin, Ireland 2019. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2019. http://dx.doi.org/10.1136/archdischild-2019-epa.668.

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Irina-Veronica, Costache y Plesca Doina Anca. "P26 Case report: severe ige-mediated cow’s milk protein allergy in a salmonella carrier". En 8th Europaediatrics Congress jointly held with, The 13th National Congress of Romanian Pediatrics Society, 7–10 June 2017, Palace of Parliament, Romania, Paediatrics building bridges across Europe. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2017. http://dx.doi.org/10.1136/archdischild-2017-313273.114.

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Logan, N. y S. Hulikere. "G126(P) Is dietician led community clinic answer to managing cow’s milk protein allergy referals". En Royal College of Paediatrics and Child Health, Abstracts of the RCPCH Conference and exhibition, 13–15 May 2019, ICC, Birmingham, Paediatrics: pathways to a brighter future. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2019. http://dx.doi.org/10.1136/archdischild-2019-rcpch.122.

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M, Petrovskaya, Namazova-Baranova L, Makarova S, Mayansky N, Zubkova I y Ereshko O. "P11 New possibilities in predicting the development of tolerance: immunophenotypes of cow’s milk protein allergy". En 8th Europaediatrics Congress jointly held with, The 13th National Congress of Romanian Pediatrics Society, 7–10 June 2017, Palace of Parliament, Romania, Paediatrics building bridges across Europe. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2017. http://dx.doi.org/10.1136/archdischild-2017-313273.99.

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Stocklosa, Mirela, Raluca Vlad, Alexandra Moraru, Irina Dijmarescu, Ioana Oprescu, Cristina Becheanu, Daniela Pacurar, Dumitru Oraseanu y Gabriela Lesanu. "P30 Why is cow’s milk protein allergy diagnosis so difficult in infants with gastrointestinal symptoms?" En 8th Europaediatrics Congress jointly held with, The 13th National Congress of Romanian Pediatrics Society, 7–10 June 2017, Palace of Parliament, Romania, Paediatrics building bridges across Europe. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2017. http://dx.doi.org/10.1136/archdischild-2017-313273.118.

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Li, S., J. Surridge y D. Roland. "G57(P) Evaluating a cow’s milk protein allergy management protocol for children presenting to the emergency department". En Royal College of Paediatrics and Child Health, Abstracts of the Annual Conference, 13–15 March 2018, SEC, Glasgow, Children First – Ethics, Morality and Advocacy in Childhood, The Journal of the Royal College of Paediatrics and Child Health. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2018. http://dx.doi.org/10.1136/archdischild-2018-rcpch.55.

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