Bibliografías temáticas / Mithramycine

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Literatura académica sobre el tema "Mithramycine"

Autor: Grafiati
Publicado: 4 de junio de 2021
Última modificación: 7 de febrero de 2022

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Artículos de revistas sobre el tema "Mithramycine"

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Hémon, Y., C. Martin, J. P. Auffray, J. J. Bonneru, C. Brunet, and J. Farisse. "Insuffisance hépato-rénale aiguë mortelle au cours d'un traitement par la mithramycine." Annales Françaises d'Anesthésie et de Réanimation 4, no. 3 (1985): 301–3. http://dx.doi.org/10.1016/s0750-7658(85)80143-x.

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Fernández, Ernestina, Ulrike Weißbach, César Sánchez Reillo, et al. "Identification of Two Genes from Streptomyces argillaceus Encoding Glycosyltransferases Involved in Transfer of a Disaccharide during Biosynthesis of the Antitumor Drug Mithramycin." Journal of Bacteriology 180, no. 18 (1998): 4929–37. http://dx.doi.org/10.1128/jb.180.18.4929-4937.1998.

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ABSTRACT Mithramycin is an antitumor polyketide drug produced byStreptomyces argillaceus that contains two deoxysugar chains, a disaccharide consisting of two d-olivoses and a trisaccharide consisting of a d-olivose, ad-oliose, and a d-mycarose. From a cosmid clone (cosAR3) which confers resistance to mithramycin in streptomycetes, a 3-kb PstI-XhoI fragment was sequenced, and two divergent genes (mtmGI andmtmGII) were identified. Comparison of the deduced products of both genes with proteins in databases showed similarities with glycosyltransferases and glucuronosyltransferases from different
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Schweer, David, J. Robert McCorkle, Jurgen Rohr, Oleg V. Tsodikov, Frederick Ueland, and Jill Kolesar. "Mithramycin and Analogs for Overcoming Cisplatin Resistance in Ovarian Cancer." Biomedicines 9, no. 1 (2021): 70. http://dx.doi.org/10.3390/biomedicines9010070.

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Ovarian cancer is a highly deadly malignancy in which recurrence is considered incurable. Resistance to platinum-based chemotherapy bodes a particularly abysmal prognosis, underscoring the need for novel therapeutic agents and strategies. The use of mithramycin, an antineoplastic antibiotic, has been previously limited by its narrow therapeutic window. Recent advances in semisynthetic methods have led to mithramycin analogs with improved pharmacological profiles. Mithramycin inhibits the activity of the transcription factor Sp1, which is closely linked with ovarian tumorigenesis and platinum-r
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Hou, Caixia, Jürgen Rohr, Sean Parkin, and Oleg V. Tsodikov. "How mithramycin stereochemistry dictates its structure and DNA binding function." MedChemComm 10, no. 5 (2019): 735–41. http://dx.doi.org/10.1039/c9md00100j.

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Lombó, Felipe, Alfredo F. Braña, Carmen Méndez, and José A. Salas. "The Mithramycin Gene Cluster of Streptomyces argillaceus Contains a Positive Regulatory Gene and Two Repeated DNA Sequences That Are Located at Both Ends of the Cluster." Journal of Bacteriology 181, no. 2 (1999): 642–47. http://dx.doi.org/10.1128/jb.181.2.642-647.1999.

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ABSTRACT Sequencing of a 4.3-kb DNA region from the chromosome ofStreptomyces argillaceus, a mithramycin producer, revealed the presence of two open reading frames (ORFs). The first one (orfA) codes for a protein that resembles several transport proteins. The second one (mtmR) codes for a protein similar to positive regulators involved in antibiotic biosynthesis (DnrI, SnoA, ActII-orf4, CcaR, and RedD) belonging to the Streptomycesantibiotic regulatory protein (SARP) family. Both ORFs are separated by a 1.9-kb, apparently noncoding region. Replacement of themtmR region by an antibiotic resista
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Fibach, Eitan, Nicoletta Bianchi, Monica Borgatti, Eugenia Prus, and Roberto Gambari. "Mithramycin induces fetal hemoglobin production in normal and thalassemic human erythroid precursor cells." Blood 102, no. 4 (2003): 1276–81. http://dx.doi.org/10.1182/blood-2002-10-3096.

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Abstract We report in this paper that the DNA-binding drug mithramycin is a potent inducer of γ-globin mRNA accumulation and fetal hemoglobin (HbF) production in erythroid cells from healthy human subjects and β-thalassemia patients. Erythroid precursors derived from peripheral blood were grown in 2-phase liquid culture. In this procedure, early erythroid progenitors proliferate and differentiate during phase 1 (in the absence of erythropoietin) into late progenitors. In phase 2, in the presence of erythropoietin, the latter cells continue their proliferation and mature into Hb-containing orth
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Remsing, Lily L., Ana M. González, Mohammad Nur-e-Alam, et al. "Mithramycin SK, A Novel Antitumor Drug with Improved Therapeutic Index, Mithramycin SA, and Demycarosyl-mithramycin SK: Three New Products Generated in the Mithramycin ProducerStreptomycesargillaceusthrough Combinatorial Biosynthesis." Journal of the American Chemical Society 125, no. 19 (2003): 5745–53. http://dx.doi.org/10.1021/ja034162h.

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Gober, Redding, Ryan Wheeler, and Jürgen Rohr. "Post-PKS enzyme complexes." MedChemComm 10, no. 11 (2019): 1855–66. http://dx.doi.org/10.1039/c9md00066f.

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Wohlert, S. E., E. Künzel, R. Machinek, C. Méndez, J. A. Salas, and J. Rohr. "The Structure of Mithramycin Reinvestigated." Journal of Natural Products 62, no. 1 (1999): 119–21. http://dx.doi.org/10.1021/np980355k.

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Aich, Palok, and Dipak Dasgupta. "Role of Magnesium Ion in Mithramycin-DNA Interaction: Binding of Mithramycin-Mg2+ Complexes with DNA." Biochemistry 34, no. 4 (1995): 1376–85. http://dx.doi.org/10.1021/bi00004a032.

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Tesis sobre el tema "Mithramycine"

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Chillou, De Churet Argento De Nunzia. "Traitement par l'association mithramycine - hydrea des syndromes myéloprolifératifs acutisés : étude de onze cas." Nancy 1, 1989. http://www.theses.fr/1989NAN11299.

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Demicheli, Cynthia. "Interaction de la mithramycine, antibiotique à propriétés antitumorales avec différents systèmes biologiques : Rôles des cations métalliques." Paris 13, 1992. http://www.theses.fr/1992PA132021.

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La mithramycine est un antibiotique antitumoral utilisé dans les traitements de cancer des testicules et dans certains cas d'hypercalcémie. Le but de notre étude a été de déterminer si l'ion mg2+, qui jusqu'à présent s'était révélé être indispensable à l'interaction ADN-mithramycine pouvait être remplacé par d'autres ions. Par ailleurs nous avons voulu déterminer si la présence de cations métalliques était également nécessaire à l'interaction de la mithramycine avec d'autres systèmes biologiques. Pour cette étude, nous avons utilisé des méthodes spectroscopiques. Dans ce contexte nous avons mo
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Leroy, Ingrid. "Nouveaux mécanismes d'induction et de régulation de la voie de signalisation apoptotique CD95/FAS." Toulouse 3, 2005. http://www.theses.fr/2005TOU30136.

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La voie apoptotique induite par le récepteur Fas et son ligand (FasL) est impliquée dans de nombreux mécanismes physiologiques et pathologiques. Cette voie se décompose en deux étapes : la formation du DISC (Death inducing signaling complex) puis la condensation de la cellule. Dans notre étude, nous nous sommes intéressés aux mécanismes de régulation et d'induction de la voie Fas. Dans ce travail nous avons montré que la protéine kinase C z est un nouveau partenaire du DISC qui régule négativement l'activation de la caspase 8. En parallèle, nous avons montré que la protéine LMP1 (Latent Membra
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Cons, Benjamin Major George. "The interaction of mithramycin with DNA." Thesis, University of Southampton, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292916.

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Weidenbach, Stevi. "INVESTIGATION OF THE MECHANISM OF ACTION FOR MITHRAMYCIN AND THE BIOSYNTHESIS OF L-REDNOSE IN SAQUAYAMYCINS." UKnowledge, 2017. http://uknowledge.uky.edu/pharmacy_etds/77.

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Natural products continue to be a major chemical lead matter for drug discovery due to their diverse chemical structures and bioactivities. Clinically significant natural products include anti-cancer and anti-infective compounds and while many more of these compounds show promising bioactivity, their clinical relevance is often limited by toxicity or poor solubility. Combinatorial biosynthesis can be employed to modify existing chemical scaffolds towards reducing these limitations. To fully take advantage of these biochemical tools, it is important to understand the biosynthesis and mechanism
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Nybo, Stephen Eric. "ISOLATION AND ELUCIDATION OF THE CHRYSOMYCIN BIOSYNTHETIC GENE CLUSTER AND ALTERING THE GLYCOSYLATION PATTERNS OF TETRACENOMYCINS AND MITHRAMYCIN-PATHWAY MOLECULES." UKnowledge, 2011. http://uknowledge.uky.edu/gradschool_diss/812.

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Natural products occupy a central role as the majority of currently used antibiotic and anticancer agents. Among these are type-II polyketide synthase (PKS)-derived molecules, or polyketides, which are produced by many representatives of the genus Streptomyces. Some type-II polyketides, such as the tetracyclines and the anthracycline doxorubicin, are currently employed as therapeutics. However, several polyketide molecules exhibit promising biological activity, but due to toxic side effects or solubility concerns, remain undeveloped as drugs. Gilvocarcin V (GV) (topoisomerase II inhibitor) has
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Eckenrode, Joseph Michael. "DEVELOPMENT OF MITHRAMYCIN ANALOGUES WITH IMPROVED EFFICACY AND REDUCED TOXICITY FOR TREATMENT OF ETS-DEPENDENT TUMORS IN EWING SARCOMA AND PROSTATE CANCER." UKnowledge, 2019. https://uknowledge.uky.edu/pharmacy_etds/107.

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Introduction: Genetic rearrangements in Ewing sarcoma, prostate, and leukemia cells result in activation of oncogenic ETS transcription factor fusions. Mithramycin (MTM) has been identified as an inhibitor of EWS-FLI1 transcription factor, a gene fusion product responsible for oncogenesis in Ewing sarcoma. Despite preclinical success, a phase I/II clinical trial testing MTM therapy in refractory Ewing sarcoma was terminated. Liver and blood toxicities resulted in dose de-escalation and sub-therapeutic exposures. However, the promise of selectively targeting oncogenic ETS transcription factors
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Downey, Theresa E. "INVESTIGATING STRUCTURE AND PROTEIN-PROTEIN INTERACTIONS OF KEY POST-TYPE II PKS TAILORING ENZYMES." UKnowledge, 2014. http://uknowledge.uky.edu/pharmacy_etds/35.

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Type II polyketide synthase (PKS) produced natural products have proven to be an excellent source of pharmacologically relevant molecules due to their rich biological activities and chemical scaffolds. Type II-PKS manufactured polyketides share similar polycyclic aromatic backbones leaving their diversity to stem from various chemical additions and alterations facilitated by post-PKS tailoring enzymes. Evidence suggests that post-PKS tailoring enzymes form complexes in order to facilitate the highly orchestrated process of biosynthesis. Thus, protein-protein interactions between these enzymes
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Chen, Jhong-Min. "Chemoenzymatic Studies to Enhance the Chemical Space of Natural Products." UKnowledge, 2015. http://uknowledge.uky.edu/pharmacy_etds/48.

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Natural products provide some of the most potent anticancer agents and offer a template for new drug design or improvement with the advantage of an enormous chemical space. The overall goal of this thesis research is to enhance the chemical space of two natural products in order to generate novel drugs with better in vivo bioactivities than the original natural products. Polycarcin V (PV) is a gilvocarcin-type antitumor agent with similar structure and comparable bioactivity with the principle compound of this group, gilvocarcin V (GV). Modest modifications of the polyketide-derived tetracycli
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Shih-Yuan, Chen, and 陳仕元. "A Molecular Dynamics Study on the Interaction in Anticancer Drug (Mithramycin)-DNA Recognition." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/c526rw.

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碩士<br>國立清華大學<br>生命科學系<br>92<br>Recent NMR study has shown that the Mg2+-coordinated Mithramycin(MTR) dimer is a DNA-binding antitumor agent bound to a widened minor groove. Centering about the sequence-specific (G-C)·(G-C) binding site leads to the significant curvature of the helix conformation which facilitates binding of the dimer drug, such as the kink at the inter-mediate TpA step. Thus its minor groove is widened from B- to A-type. For this DNA model, d(TAGCTAGCTA)2, which contains two partially overlapping potential binding sites(GpC), recent spectroscopic study shows that the different
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Capítulos de libros sobre el tema "Mithramycine"

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Nielsen, Peter E., Benjamin M. G. Cons, Keith R. Fox, and Vibeke Beck Sommer. "Uranyl Photofootprinting. DNA Structural Changes Upon Binding of Mithramycin." In The Jerusalem Symposia on Quantum Chemistry and Biochemistry. Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-011-3728-7_28.

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Ryan, Will G. "Two Decades of Experience in the Treatment of Paget’s Disease of Bone with Plicamycin (Mithramycin)." In Paget’s Disease of Bone. Springer US, 1991. http://dx.doi.org/10.1007/978-1-4684-2307-5_13.

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Holstege, Christopher P. "Mithramycin." In Encyclopedia of Toxicology. Elsevier, 2005. http://dx.doi.org/10.1016/b0-12-369400-0/00634-7.

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Holstege, C. P. "Mithramycin." In Encyclopedia of Toxicology. Elsevier, 2014. http://dx.doi.org/10.1016/b978-0-12-386454-3.00752-1.

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Crissman, Harry A., and Robert A. Tobey. "Chapter 10 Specific Staining of DNA with the Fluorescent Antibiotics, Mithramycin, Chromomycin, and Olivomycin." In Flow Cytometry. Elsevier, 1990. http://dx.doi.org/10.1016/s0091-679x(08)60515-4.

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Actas de conferencias sobre el tema "Mithramycine"

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Scroggins, Bradley T., Jeffery F. Burkeen, Eun Joo Chung, et al. "Abstract 1799: Mithramycin A as a radiation sensitizer." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-1799.

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Hayden, Reiya C., Caixia Hou, Prithiba Mitra, et al. "Abstract 2954: Mithramycin analogues disrupt ETS transcription factor DNA binding." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-2954.

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Hayden, Reiya C., Caixia Hou, Prithiba Mitra, et al. "Abstract 2954: Mithramycin analogues disrupt ETS transcription factor DNA binding." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-2954.

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Eckenrode, Joseph, Jamie Horn, Jhong-Min Chen, Jurgen Rohr, and Markos Leggas. "Abstract 2628: Mithramycin analogs with reduced toxicity for EWS-FLI1 targeting." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-2628.

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Flores, Guillermo, Susan Kitchen-Goosen, Brandon Oswald, et al. "Abstract 2882: Mithramycin impedes EWS-FLI1 driven transcription by preventing target promoter clearance." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-2882.

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Banerjee, Amrita, Chandrima Das, and Dipak Dasgupta. "Abstract B44: Mithramycin exhibits dual binding mode and acts as an epigenetic switch." In Abstracts: AACR Special Conference on Chromatin and Epigenetics in Cancer - June 19-22, 2013; Atlanta, GA. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.cec13-b44.

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Flores, Guillermo, Susan Kitchen-Goosen, Brandon Oswald, et al. "Abstract 2882: Mithramycin impedes EWS-FLI1 driven transcription by preventing target promoter clearance." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-2882.

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Ray, Anish, Bhavani Nagarajan, Umesh T. Sankpal, et al. "Abstract 1532: Mithramycin induces the antiproliferative activity of chemotherapeutic agents in Ewing sarcoma cells." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-1532.

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Sissung, Tristan M., Phoebe A. Huang, Ralph Hauke, et al. "Abstract 2943: Severe hepatotoxicity of mithramycin therapy caused by altering expression of hepatocellular bile transporters." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-2943.

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Osgood, Christy, Nichole Maloney, Christopher G. Kidd, et al. "Abstract 1612: Identification of mithramycin analogs with improved targeting of the EWS/FLI1 transcription factor." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-1612.

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