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Artículos de revistas sobre el tema "Mrs. Claus series"

Autor: Grafiati

Publicado: 26 de julio de 2024

Última modificación: 31 de julio de 2025

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1

Gamber, Wendy. "“The Notorious Mrs. Clem”: Gender, Class, and Criminality in Gilded Age America." Journal of the Gilded Age and Progressive Era 11, no. 3 (2012): 313–43. http://dx.doi.org/10.1017/s1537781412000242.

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This essay explores the story of Nancy Clem, an outwardly respectable Indianapolis confidence woman and alleged murderess, in the context of changing constructions of class, gender, and criminality. It examines various ways in which lawyers, newspaper reporters, and ordinary citizens struggled to understand a woman who did not fit preexisting conceptions of gender and crime. A series of high-profile cases involving bourgeois criminals and (more than likely) Clem's own social aspirations allowed cultural commentators to portray her as a “genteel murderess.” Upon her release from prison after an

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2

Christy, Donna M. "Whimsical Path to Math: Implementing the Navigations Series." Teaching Children Mathematics 12, no. 6 (2006): 323–31. http://dx.doi.org/10.5951/tcm.12.6.0323.

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A Whimsical Path to Math, a series of themebased mathematics lessons, was inspired by my experience during a local school's Reading Week program. Dressed in costume as Mrs. Springtime-Fairy and reading Waiting for Wings (Ehlert 2001) to a class of prekindergarten students, I was awed by the delight and enthusiasm that the students displayed. Being a mathematics teacher, their reaction inspired me to create a mathematically rich series of thematic lessons laced with storybook fantasy for students in prekindergarten through grade 2.

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3

Kumar, Saurabh, Jitendra Kumar, Vikas Kumar Sharma, and Varun Agiwal. "Random order autoregressive time series model with structural break." Model Assisted Statistics and Applications 15, no. 3 (2020): 225–37. http://dx.doi.org/10.3233/mas-200490.

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This paper deals with the problem of modelling time series data with structural breaks occur at multiple time points that may result in varying order of the model at every structural break. A flexible and generalized class of Autoregressive (AR) models with multiple structural breaks is proposed for modelling in such situations. Estimation of model parameters are discussed in both classical and Bayesian frameworks. Since the joint posterior of the parameters is not analytically tractable, we employ a Markov Chain Monte Carlo method, Gibbs sampling to simulate posterior sample. To verify the or

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4

Ferry, Emma. "“A Pair of Scissors, and One Daring, If Trembling, Snip—!”: Making Mrs. Oliphant’s Dress." Victorian Review 49, no. 1 (2023): 83–108. http://dx.doi.org/10.1353/vcr.2023.a925220.

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Abstract: Devised and edited by the Reverend W.J. Loftie, the Art at Home Series, published by Macmillan & Co. between 1876 and 1883, was a highly successful collection of domestic advice manuals aimed at a growing lower-middle-class readership. This paper focuses upon the volume in the series devoted to the subject of the book Dress , written in 1878 by the well-known Scottish novelist Mrs. Margaret Oliphant (1828–97). Drawing upon previously unpublished sources from the Macmillan Archive and contemporary reviews, this article charts the book’s production and initial reception to suggest

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5

Ohno, Yasuo, and Takashi Taniguchi. "Relations among Dirichlet series whose coefficients are class numbers of binary cubic forms II." Mathematical Research Letters 21, no. 2 (2014): 363–78. http://dx.doi.org/10.4310/mrl.2014.v21.n2.a12.

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6

Turley, Patrick K. "The Don Spring Memorial Oration - Part II: Early Management of the Developing Class III Malocclusion." Australasian Orthodontic Journal 13, no. 1 (1993): 19–22. http://dx.doi.org/10.2478/aoj-1993-0021.

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Abstract This article is the second in the two-part series comprising The Don Spring Memorial Oration delivered by Dr Patrick Turley at the Hamilton Island meeting of the Australian Foundation for Research and Education, in September 1992. The article has been reprinted with the permission of the Editor of the Pacific Coast Society of Orthodontists’ Bulletin. Both articles in the series have been smnmarized by Andrea L. Feature D.D.S., M.S..

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7

Lipovetsky, Stan. "Modified ridge and other regularization criteria: A brief review on meaningful regression models." Model Assisted Statistics and Applications 16, no. 3 (2021): 225–27. http://dx.doi.org/10.3233/mas-210536.

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The work describes a series of techniques designed to obtain regression models resistant to multicollinearity and having some other features needed for meaningful results. These models include enhanced ridge-regressions with several regularization parameters, regressions by data segments and by levels of the dependent variable, latent class models, unitary response, models, orthogonal and equidistant regressions, minimization in Lp-metric, and other criteria and models. All the approaches have been practically implemented in various projects and found useful for decision making in economics, m

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8

Vivi Hariyanti Safitri, Supardi Supardi, and Faisal Suhendi. "Analisis Kemampuan Siswa Kelas 11 MA Daarul Uluum Lido Memecahkan Soal Baris dan Deret Via Google Form." Pentagon : Jurnal Matematika dan Ilmu Pengetahuan Alam 3, no. 2 (2025): 116–26. https://doi.org/10.62383/pentagon.v3i2.546.

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The research conducted at MAS Daarul Uluum Lido Bogor Jl. Mayjen Hr Edi Sukma KM 22, Ciburuy Village, Cigombong District, Bogor Regency, aims to analyze the level of Mathematical Problem Solving Ability in the Sequence and Series Material of Class 11 at MA Daarul Uluum Lido through Google Form Media. The research method used is qualitative research with the sampling technique used is purposive sampling. The target population in this study were all class 11 students at MAS Daarul Uluum Lido. The accessible population in this study was only class 11 D MIA MAS Daarul Uluum Lido students. The rese

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9

Wilsani, Wilsani, Faizal Chan, Muhammad Sholeh, and Zelly Putriani. "Analysis of the Implementation of the Pancasila Student’s Profile for Strengthening Project in the Merdeka Curriculum in Indonesia’s Elementary Schools." At-Taqaddum 15, no. 2 (2023): 126–39. http://dx.doi.org/10.21580/at.v15i2.17884.

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This research aims to determine how teachers implement the Pancasila Student Profile Strengthening Project in the Independent Curriculum in class V in elementary schools. This research was conducted at Jambi City State Elementary School (SD) 1/IV in the even semester in the academic year of 2022/2023. This research uses a qualitative research methodology with a phenomenological research type. Research data was obtained directly through data collection techniques: observation, interviews, and documentation with the class V homeroom teachers, namely Mrs. S, Mr. AP, Mrs. NEP, Mr. VK, and Mrs. F.

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10

Bhatia, Kartik, Hans Kortman, Christopher Blair, et al. "Mechanical thrombectomy in pediatric stroke: systematic review, individual patient data meta-analysis, and case series." Journal of Neurosurgery: Pediatrics 24, no. 5 (2019): 558–71. http://dx.doi.org/10.3171/2019.5.peds19126.

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OBJECTIVEThe role of mechanical thrombectomy in pediatric acute ischemic stroke is uncertain, despite extensive evidence of benefit in adults. The existing literature consists of several recent small single-arm cohort studies, as well as multiple prior small case series and case reports. Published reports of pediatric cases have increased markedly since 2015, after the publication of the positive trials in adults. The recent AHA/ASA Scientific Statement on this issue was informed predominantly by pre-2015 case reports and identified several knowledge gaps, including how young a child may under

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11

Pernik, Indrek, Brant J. Maitland, Andreas Stasch, and Cameron Jones. "Synthesis and attempted reductions of bulky 1,3,5-triazapentadienyl groups 2 and 13 halide complexes." Canadian Journal of Chemistry 96, no. 6 (2018): 513–21. http://dx.doi.org/10.1139/cjc-2017-0548.

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Three extremely bulky 1,3,5-triazapentadienes, ArNNNH (ArNNN = N{C(But)=N(Ar)}2; Ar = Mes (mesityl), Dep (2,6-diethylphenyl), or Dip (2,6-diisopropylphenyl)) have been prepared and structurally characterized. These are readily deprotonated, yielding a series of lithium and potassium triazapentadienyl complexes, one of which, (DipNNN)Li, has been structurally characterized. Similarly, three monomeric triazapentadienyl magnesium iodide complexes, (ArNNN)MgI(OEt2), and a dimeric calcium counterpart, {(MesNNN)Ca(THF)(μ-I)}2, have been prepared. Attempts to reduce the former gave homoleptic bis(tri

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12

Widiyarti, Gemala. "EFFORTS TO IMPROVE THE ABILITY OF WRITING SIMPLE PARAGRAPH IN INDONESIAN SUBJECTS USING STUDENT IMAGE SERIES CLASS III MIS AL QUBA MEDAN." Sensei International Journal of Education and Linguistic 2, no. 3 (2023): 569–75. http://dx.doi.org/10.53768/sijel.v2i3.104.

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In an effort to realize an increase in students' writing, teachers are expected to be able to choose and apply instructional media that can convey learning objectives well to students. The formulation of the problem in this study is whether the application of serial picture media can improve the ability to write simple paragraphs in Indonesian class III students, for example. Al Quba Medan. The purpose of this study was to find out and describe the learning outcomes in the form of the ability to write simple paragraphs using picture series media in Indonesian language learning class III III Mi

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13

Ribble, Wendy, Walter E. Hill, Urs A. Ochsner, et al. "Discovery and Analysis of 4H-Pyridopyrimidines, a Class of Selective Bacterial Protein Synthesis Inhibitors." Antimicrobial Agents and Chemotherapy 54, no. 11 (2010): 4648–57. http://dx.doi.org/10.1128/aac.00638-10.

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ABSTRACT Bacterial protein synthesis is the target for numerous natural and synthetic antibacterial agents. We have developed a poly(U) mRNA-directed aminoacylation/translation protein synthesis system composed of phenyl-tRNA synthetases, ribosomes, and ribosomal factors from Escherichia coli. This system, utilizing purified components, has been used for high-throughput screening of a small-molecule chemical library. We have identified a series of compounds that inhibit protein synthesis with 50% inhibitory concentrations (IC50s) ranging from 3 to 14 μM. This series of compounds all contained

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14

Kim, Won Jun, Edie I. Crosse, Emma De Neef, et al. "Mis-Splicing Derived Neoantigens and Cognate T Cell Receptors in Splicing Factor Mutant Myeloid Neoplasms." Blood 144, Supplement 1 (2024): 343. https://doi.org/10.1182/blood-2024-198639.

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Mutations in RNA splicing factors are the most common class of genetic alterations in MDS and are also prevalent in AML. These mutations cause recurrent splicing changes in a highly sequence-specific manner across patients and cancer types. We hypothesized that a subset of these aberrant splicing changes would generate “public” neoantigens (i.e. shared across patients) that can serve as potential targets of T cell-based immunotherapies. Here we identify a series of shared, bona fide neoantigens induced by leukemia-associated mutations in RNA splicing factors SRSF2 and ZRSR2. We validate in vit

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15

Roney, John B. "[Mis-]managing Fisheries on the West Coast of Ireland in the Nineteenth Century." Humanities 8, no. 1 (2019): 4. http://dx.doi.org/10.3390/h8010004.

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This study focuses on the cultural heritage of artisan coastal fishing in the west of Ireland in the 19th century. The town and port of Dingle, County Kerry, offers an important case study on the progress of local development and changing British policies. While there was clearly an abundance of fish, the poverty and the lack of capital for improvements in ports, vessels, gear, education, and transportation, left the fishing industry underdeveloped until well after the 1890s. In addition, a growing rift developed between the traditional farmer-fishermen and the new middle-class capitalist comp

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16

Felli, Nadia, Elvira Pelosi, Rosanna Botta, et al. "Lineage-Specific Expression and Functional Relevance of MicroRNA Genes in Normal Hematopoiesis." Blood 106, no. 11 (2005): 2263. http://dx.doi.org/10.1182/blood.v106.11.2263.2263.

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Abstract MicroRNAs (miRs) are a class of a small (~ 22nt) RNAs, which play an important role in the negative regulation of gene expression by base-pairing to complementary sites on the target mRNAs. While it is established that miRs are involved in a variety of basic processes, e.g., cell proliferation and apoptosis, neural development, fat metabolism and stress response, little is known on their expression and function in hematopoiesis. In order to investigate miR expression in erythropoietic (E), megakaryocytic (Mk), granulopoietic (G) and monocytopoietic (Mo) lineages, we have assayed their

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17

Leininger, Becca, Makayla Quinn, Jeffrey Jalkio, Rahaf Bahajry, Mellissa Ingabire, and AnnMarie Thomas. "An Introductory Course in Electrical Circuits and Coding for Deaf and DeafBlind Middle School Students." Journal of Science Education for Students with Disabilities 26, no. 1 (2023): 1–10. http://dx.doi.org/10.14448/jsesd.15.0008.

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The Playful Learning Lab collaborated with Metro Deaf School (MDS) to design and deliver an Intro to Electronics and Computer Programming course to Deaf and DeafBlind middle school students. Four sets of 6–8 students went through an approximately 20-day course that met four days a week for 40 minutes per day. The content of the class focused on electrical circuits and computer programming. Lessons covered topics such as conductivity, closed/open circuits, series/parallel circuits, and coding. Students were introduced to the Scratch computer programming language and Makey Makey kits. The develo

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18

Gadige, Aswini Kumar, and Paremesha Paremesha. "Improvement of Philips MOS model 9 radio frequency performance with circuit level parasitic compensation." International Journal of Electrical and Computer Engineering (IJECE) 14, no. 5 (2024): 4977. http://dx.doi.org/10.11591/ijece.v14i5.pp4977-4986.

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The two circuit-level parasitic compensation techniques for the Philips metal oxide semiconductor (MOS) model 9 metal oxide semiconductor field effect transistor (MOSFET) at high frequencies (in the GHz range) are presented in this paper. The first method involves connecting the series resonant LC circuit in parallel to the drain and grounded source/bulk of the MM9; the second method involves connecting two of these MM9s in parallel to increase the drain current at higher frequencies along with parasitic compensation. Using these compensatory techniques, it is possible to reduce the impact of

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19

Blum-Tirouvanziam, U., C. Servis, A. Habluetzel, et al. "Localization of HLA-A2.1-restricted T cell epitopes in the circumsporozoite protein of Plasmodium falciparum." Journal of Immunology 154, no. 8 (1995): 3922–31. http://dx.doi.org/10.4049/jimmunol.154.8.3922.

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Abstract Localization of human MHC class I-restricted T cell epitopes in the circumsporozoite (CS) protein of the human parasite Plasmodium falciparum is an important objective in the development of antimalarial vaccines. To this purpose, we synthesized a series of overlapping synthetic 20-mer peptides, spanning the entire sequence of the 7G8 CS molecule except for the central repeat B cell domain. The P.f.CS peptides were first tested for their ability to bind to the human MHC class I HLA-A2.1 molecule on T2, a human cell line. Subsequently, the use of a series of shorter peptide analogues al

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20

Pu, Jing, Xiaoyang He, Wei Xu, et al. "The Analogs of Furanyl Methylidene Rhodanine Exhibit Broad-Spectrum Inhibitory and Inactivating Activities against Enveloped Viruses, including SARS-CoV-2 and Its Variants." Viruses 14, no. 3 (2022): 489. http://dx.doi.org/10.3390/v14030489.

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In recent years, infectious diseases caused by viral infections have seriously endangered human health, especially COVID-19, caused by SARS-CoV-2, which continues to spread worldwide. The development of broad-spectrum antiviral inhibitors is urgently needed. Here, we report a series of small-molecule compounds that proved effective against human coronaviruses (HCoV), such as SARS-CoV-2 and its variants of concern (VOCs), including Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), Delta (B.1.617.2), and Omicron (B.1.1.529), SARS-CoV, MERS-CoV, HCoV-OC43, and other viruses with class I viral fusion

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21

Kaup, Moritz, Tatjana Gruber-Rouh, Jan E. Scholtz, et al. "Low-dose CT pulmonary angiography on a 15-year-old CT scanner: a feasibility study." Acta Radiologica Open 5, no. 12 (2016): 205846011668437. http://dx.doi.org/10.1177/2058460116684371.

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Background Computed tomography (CT) low-dose (LD) imaging is used to lower radiation exposure, especially in vascular imaging; in current literature, this is mostly on latest generation high-end CT systems. Purpose To evaluate the effects of reduced tube current on objective and subjective image quality of a 15-year-old 16-slice CT system for pulmonary angiography (CTPA). Material and Methods CTPA scans from 60 prospectively randomized patients (28 men, 32 women) were examined in this study on a 15-year-old 16-slice CT scanner system. Standard CT (SD) settings were 100 kV and 150 mAs, LD setti

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22

Lu, Dan, Kefang Liu, Di Zhang, et al. "Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats." PLOS Biology 17, no. 9 (2019): e3000436. https://doi.org/10.5281/zenodo.13448034.

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(Uploaded by Plazi for the Bat Literature Project) Bats harbor many zoonotic viruses, including highly pathogenic viruses of humans and other mammals, but they are typically asymptomatic in bats. To further understand the antiviral immunity of bats, we screened and identified a series of bat major histocompatibility complex (MHC) I Ptal-N*01:01–binding peptides derived from four different bat-borne viruses, i.e., Hendra virus (HeV), Ebola virus (EBOV), Middle East respiratory syndrome coronavirus (MERS-CoV), and H17N10 influenza-like virus. The structures of Ptal-N*01:01 display unusual peptid

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23

Lu, Dan, Kefang Liu, Di Zhang, et al. "Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats." PLOS Biology 17, no. 9 (2019): e3000436. https://doi.org/10.5281/zenodo.13448034.

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(Uploaded by Plazi for the Bat Literature Project) Bats harbor many zoonotic viruses, including highly pathogenic viruses of humans and other mammals, but they are typically asymptomatic in bats. To further understand the antiviral immunity of bats, we screened and identified a series of bat major histocompatibility complex (MHC) I Ptal-N*01:01–binding peptides derived from four different bat-borne viruses, i.e., Hendra virus (HeV), Ebola virus (EBOV), Middle East respiratory syndrome coronavirus (MERS-CoV), and H17N10 influenza-like virus. The structures of Ptal-N*01:01 display unusual peptid

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24

Lu, Dan, Kefang Liu, Di Zhang, et al. "Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats." PLOS Biology 17, no. 9 (2019): e3000436. https://doi.org/10.5281/zenodo.13448034.

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(Uploaded by Plazi for the Bat Literature Project) Bats harbor many zoonotic viruses, including highly pathogenic viruses of humans and other mammals, but they are typically asymptomatic in bats. To further understand the antiviral immunity of bats, we screened and identified a series of bat major histocompatibility complex (MHC) I Ptal-N*01:01–binding peptides derived from four different bat-borne viruses, i.e., Hendra virus (HeV), Ebola virus (EBOV), Middle East respiratory syndrome coronavirus (MERS-CoV), and H17N10 influenza-like virus. The structures of Ptal-N*01:01 display unusual peptid

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25

Lu, Dan, Kefang Liu, Di Zhang, et al. "Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats." PLOS Biology 17, no. 9 (2019): e3000436. https://doi.org/10.5281/zenodo.13448034.

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(Uploaded by Plazi for the Bat Literature Project) Bats harbor many zoonotic viruses, including highly pathogenic viruses of humans and other mammals, but they are typically asymptomatic in bats. To further understand the antiviral immunity of bats, we screened and identified a series of bat major histocompatibility complex (MHC) I Ptal-N*01:01–binding peptides derived from four different bat-borne viruses, i.e., Hendra virus (HeV), Ebola virus (EBOV), Middle East respiratory syndrome coronavirus (MERS-CoV), and H17N10 influenza-like virus. The structures of Ptal-N*01:01 display unusual peptid

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26

Lu, Dan, Kefang Liu, Di Zhang, et al. "Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats." PLOS Biology 17, no. 9 (2019): e3000436. https://doi.org/10.5281/zenodo.13448034.

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(Uploaded by Plazi for the Bat Literature Project) Bats harbor many zoonotic viruses, including highly pathogenic viruses of humans and other mammals, but they are typically asymptomatic in bats. To further understand the antiviral immunity of bats, we screened and identified a series of bat major histocompatibility complex (MHC) I Ptal-N*01:01–binding peptides derived from four different bat-borne viruses, i.e., Hendra virus (HeV), Ebola virus (EBOV), Middle East respiratory syndrome coronavirus (MERS-CoV), and H17N10 influenza-like virus. The structures of Ptal-N*01:01 display unusual peptid

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27

Burrahman, Habib, Andreas Kurniawan Silitonga, Ilham Haris Batubara, and Ahmad Fadlan. "PENGARUH ASIMILASI MODEL CUACA WEATHER RESEARCH FORECAST (WRF) DENGAN DATA RADIASI SATELIT TERHADAP ESTIMASI CURAH HUJAN (Studi Kasus Stasiun Meteorologi Pattimura‒Ambon Tanggal 24-25 Juli 2013)." Prosiding SNFA (Seminar Nasional Fisika dan Aplikasinya) 3 (February 28, 2019): 118. http://dx.doi.org/10.20961/prosidingsnfa.v3i0.28524.

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<p class="AbstractEnglish"><strong>Abstract:</strong> Numerical weather predictions are currently being developed to address the need for high resolution rainfall forecasting. However, numerical weather forecasts in Indonesia are still problematic in terms of the accuracy of numerical models. Several previous studies have shown that modeling accuracy is strongly influenced by errors in the initial condition data. This study examines efforts from the research and development of the Weather Forecast and Forecast (WRF) model of preliminary data using a satellite beam assimilatio

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28

Di Martino, Thomas Di, Régis Guinvarc’h, Laetitia Thirion-Lefevre, and Elise Colin. "FARMSAR: Fixing AgRicultural Mislabels Using Sentinel-1 Time Series and AutoencodeRs." Remote Sensing 15, no. 1 (2022): 35. http://dx.doi.org/10.3390/rs15010035.

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This paper aims to quantify the errors in the provided agricultural crop types, estimate the possible error rate in the available dataset, and propose a correction strategy. This quantification could establish a confidence criterion useful for decisions taken on this data or to have a better apprehension of the possible consequences of using this data in learning downstream functions such as classification. We consider two agricultural label errors: crop type mislabels and mis-split crops. To process and correct these errors, we design a two-step methodology. Using class-specific convolutional

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D’Orsi, Rosarita, Maria Funicello, Teresa Laurita, Paolo Lupattelli, Federico Berti, and Lucia Chiummiento. "The Pseudo-Symmetric N-benzyl Hydroxyethylamine Core in a New Series of Heteroarylcarboxyamide HIV-1 Pr Inhibitors: Synthesis, Molecular Modeling and Biological Evaluation." Biomolecules 11, no. 11 (2021): 1584. http://dx.doi.org/10.3390/biom11111584.

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Here, we report the synthesis, enzyme inhibition and structure–activity relationship studies of a new potent class of HIV-1 protease inhibitors, which contain a pseudo-symmetric hydroxyethylamine core and heteroarylcarboxyamide moieties. The simple synthetic pathway furnished nine compounds in a few steps with high yields. The compounds were designed taking into account our previous results on other series of inhibitors with different substituents at P’ and P’’ and different ways of linking them to the inhibitor core. Potent inhibitory activity was obtained with nanomolar IC50 values measured

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Gibbard, P. L., R. G. West, and P. D. Hughes. "Pleistocene glaciation of Fenland, England, and its implications for evolution of the region." Royal Society Open Science 5, no. 1 (2018): 170736. http://dx.doi.org/10.1098/rsos.170736.

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Detailed investigation of landforms and their underlying deposits on the eastern margin of Fenland, East Anglia, demonstrated that they represent a series of glaciofluvial delta-fan and related sediments. Associated with these deposits are glacially dislocated sediments including tills, meltwater and pre-existing fluvial sediments. These ‘Skertchly Line’ deposits occur in the context of a substantial ice lobe that entered Fenland from the N to NE, dammed the streams entering the basin and caused glacial lakes to form in the valleys on the margins. Bulldozing by the ice lobe caused a series of

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31

Nakajima, Kenichiro, Shalini Jain, Inigo Ruiz de Azua, Sara M. McMillin, Mario Rossi та Jürgen Wess. "Minireview: Novel Aspects of M3 Muscarinic Receptor Signaling in Pancreatic β-Cells". Molecular Endocrinology 27, № 8 (2013): 1208–16. http://dx.doi.org/10.1210/me.2013-1084.

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The release of insulin from pancreatic β-cells is regulated by a considerable number of G protein–coupled receptors. During the past several years, we have focused on the physiological importance of β-cell M3 muscarinic acetylcholine receptors (M3Rs). At the molecular level, the M3R selectively activates G proteins of the Gq family. Phenotypic analysis of several M3R mutant mouse models, including a mouse strain that lacks M3Rs only in pancreatic β-cells, indicated that β-cell M3Rs play a key role in maintaining blood glucose levels within a normal range. Additional studies with transgenic M3R

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32

Eaton, David W., Erick Adam, Bernd Milkereit, et al. "Enhancing base-metal exploration with seismic imagingThis article is one of a series of papers published in this Special Issue on the theme Lithoprobe — parameters, processes, and the evolution of a continent." Canadian Journal of Earth Sciences 47, no. 5 (2010): 741–60. http://dx.doi.org/10.1139/e09-047.

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Commencing in 1988 and continuing for 5 years, Lithoprobe acquired a series of high-resolution seismic experiments within and near base-metal mining camps in Canada, including the Abitibi subprovince of Quebec and Ontario, the world-class Sudbury Ni–Cu mining district, the Buchans mine in Newfoundland, and the Thompson Ni belt in Manitoba. This work, undertaken in close cooperation with the Geological Survey of Canada and major Canadian mining companies, stimulated an intensive and broadened series of followup studies with the common objective of assessing potential applications of multichanne

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VAN der AAR, Ellen M., Tialda BOUWMAN, Jan N. M. COMMANDEUR, and Nico P. E. VERMEULEN. "Structure-activity relationships for chemical and glutathione S-transferase-catalysed glutathione conjugation reactions of a series of 2-substituted 1-chloro-4-nitrobenzenes." Biochemical Journal 320, no. 2 (1996): 531–40. http://dx.doi.org/10.1042/bj3200531.

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Glutathione S-transferases (GSTs) constitute an important class of phase II (de)toxifying enzymes, catalysing the conjugation of glutathione (GSH) with electrophilic compounds. In the present study, Km, kcat and kcat/Km values for the rat GST 1-1-, 3-3-, 4-4- and 7-7-catalysed conjugation reactions between GSH and a series of 10 different 2-substituted 1-chloro-4-nitrobenzenes, and the second-order rate constants (ks) of the corresponding base-catalysed reactions, were correlated with nine classical physicochemical parameters (electronic, steric and lipophilic) of the substituents and with 16

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Doubrovina, Ekaterina, Jacob Dupont, Deepa Trivedi, Elena Kanaeva, and Richard J. O’Reilly. "Sensitization of Human T Cells with Overlapping Pentadecapeptides Spanning the Wt1 Protein Induces Expansion of Leukemocidal T Cells Specific for Both Previously Identified and Novel WT1 Epitopes." Blood 104, no. 11 (2004): 3873. http://dx.doi.org/10.1182/blood.v104.11.3873.3873.

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Abstract The oncofetal protein, WT1, is differentially expressed in 60–80% of acute leukemias and CML. Previously, four peptide epitopes presented by HLA-A0201 or HLA-A2402 have been identified. We used a pool of 15-mers with 10 amino acid overlaps spanning the full sequence of WT1, loaded on autologous monocyte-derived dendritic cells or EBV-transformed BLCL to sensitize and raise T cell lines from a series of normal donors expressing or not expressing HLA-A0201 or HLA-A2402. Specific 15-mers eliciting responses were identified by quantitating IFNg+ CD8+ or CD4+ T cell responses to secondary

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Doubrovina, Ekaterina, Jacob Dupont, Elena Kanaeva, and Richard J. O’Reilly. "Leukemia-Reactive Cytotoxic CD8+ and CD4+ T-Cells Specific for Novel WT-1 Epitopes Are Generated In Vitro by Sensitization with Overlapping Pentadecapeptides (15-mers) Spanning the Wilms Tumor Protein." Blood 110, no. 11 (2007): 1810. http://dx.doi.org/10.1182/blood.v110.11.1810.1810.

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Abstract The Wilms Tumor protein, WT-1 is differentially expressed in 60–80% of acute leukemias and CML. Evidence also suggests WT-1 expression in clonogenic leukemia stem cells, making WT-1 an attractive target for T-cell therapy. However, to date, only a limited number of immunogenic epitopes have been identified. To address this limitation, we employed a pool of 15-mers with 10 amino acid overlaps spanning the complete sequence of WT-1 loaded on autologous monocyte derived dendritic cells or EBV transformed BLCL to sensitize T-cells from normal donors of varied HLA genotypes. Specific 15-me

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Reichert, Ines, Raju S. Ahluwalia, Omar Musabahi, and Shirley Lyle. "Minimally Invasive Intra-Calcaneal Fractures vs Conservative Treatment: A Propensity Score Matched Cohort Series." Foot & Ankle Orthopaedics 7, no. 4 (2022): 2473011421S0090. http://dx.doi.org/10.1177/2473011421s00903.

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Category: Trauma; Hindfoot Introduction/Purpose: We prospectively assessed the impact of minimally invasive internal fixation of displaced intra-articular calcaneal fractures (DIACF) results in better health outcomes up to 2 years post- injury than non-operative management. Methods: All isolated calcaneal fractures were reviewed and the decision to treat was made by a multidisciplinary meeting. Operative-treatment protocol involved sinus-tarsi approach or per-cutaneous reduction & internal fixation under the care of a fellowship-trained-foot and ankle surgeon. Non-operative protocol involv

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Sullivan, R. J., Y. Hoshida, J. Brunet, et al. "A single center experience with high-dose (HD) IL-2 treatment for patients with advanced melanoma and pilot investigation of a novel gene expression signature as a predictor of response." Journal of Clinical Oncology 27, no. 15_suppl (2009): 9003. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.9003.

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9003 Background: HD IL-2 remains one of two FDA-approved therapies for the treatment of patients (pts) with advanced melanoma. Initial studies conducted 15–20 years ago reported 16% response rate with 8% of pts achieving durable responses. The toxicity of HD IL-2 limits its application to pts treated in specialized centers. We present the clinical outcome of pts treated over a recent 2 year period with HD IL-2 at a single institution and an associated retrospective pilot study evaluating the predictive value of a novel tumor gene expression signature. Methods: Clinical and radiological data we

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Bukhtyak, Mikhail S., and Dmitrii E. Yesipov. "Pseudo-minimal surfaces of revolution." Vestnik Tomskogo gosudarstvennogo universiteta. Matematika i mekhanika, no. 76 (2022): 5–19. http://dx.doi.org/10.17223/19988621/76/1.

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This paper is a follow-up to the first author’s series of works about shape modeling of orthotropic elastic material that takes the equilibrium form inside the area with the specified boundaries. M.S. Bukhtyak, in a number of his publications of 20162020, proposed an approach to the model building based on the application of surfaces with a constant ratio of principal curvatures. These surfaces are named pseudo-minimal surfaces. The theorem of existence has been demonstrated and the finitely-element model has been built. The condition distinguishing the class of pseudo-minimal surfaces, as app

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McKernan, Stuart. "“Microscopic Explorations“: One Kit Many uses." Microscopy and Microanalysis 6, S2 (2000): 1174–75. http://dx.doi.org/10.1017/s1431927600038368.

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Since 1996 the Minnesota Microscopy Society (MMS) has had several different opportunities to use the “Microscopic Explorations” [1] handbook that has been developed by MSA in collaboration with the Lawrence Hall of Science [2] as part of their Great Explorations in Math and Science (GEMS) series. Initially we used a beta-test version of the manual and worked with several different schools in the St. Paul's school district. Since then we have broadened the range of our outreach, and have interacted with different school districts, as well as local museums and other youth and community organizat

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Macías Borrego, Manuel. "Computer-Assisted Language Learning (CALL) and multiple intelligences theory: Curricular design in vocational formation in Spain." Journal of Digital Educational Technology 3, no. 2 (2023): ep2306. http://dx.doi.org/10.30935/jdet/13237.

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This study aims to design a class proposal to improve student motivation in English as a foreign language in vocational formation in Spain through computer-assisted language learning (CALL) and gamification. Our main objective is to ensure that through this project, they not only gain a series of new tools, but that they can also learn both specific contents of the target subject: English as a foreign language in vocational formation in Spain. For this last objective, the use of multiple intelligences (MIs) in teaching can serve to destigmatize atypical intelligences. Atypical intelligences ar

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Brown, Walter L., and Abbas Ourmazd. "Ion-Assisted Processing of Electronic Materials." MRS Bulletin 17, no. 6 (1992): 23–25. http://dx.doi.org/10.1557/s0883769400041415.

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The fabrication of a state-of-the-art silicon chip consists of a carefully composed sequence of “steps.” The length, complexity, and place of each step within this process is analogous to that of a musical phrase within a long sonata. Just as a sonata consists of a series of recurring but evolving themes, a “process” utilizes a number of basic techniques that recur in a variety of contexts. A typical modern process consists of about 350 “steps.” Roughly a fifth of them belong to the class of ionassisted processing. These range from a variety of ion implantation modules, through sputter deposit

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Duminuco, Andrea, Antonella Nardo, Bruno Garibaldi, et al. "Prediction of Survival and Prognosis Migration from Gold-Standard Scores in Myelofibrosis Patients Treated with Ruxolitinib Applying the RR6 Prognostic Model in a Monocentric Real-Life Setting." Journal of Clinical Medicine 11, no. 24 (2022): 7418. http://dx.doi.org/10.3390/jcm11247418.

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The wide use of ruxolitinib, approved for treating primary and secondary myelofibrosis (MF), has revolutionized the landscape of these diseases. This molecule can reduce spleen volume and constitutional symptoms, guaranteeing patients a better quality of life and survival or even a valid bridge to bone marrow transplantation. Despite a rapid response within the first 3 to 6 months of treatment, some patients fail to achieve a significant benefit or lose early response. After ruxolitinib failure, new drugs are available to provide an additional therapeutic option for these patients. However, th

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Johansson, Sören, Michelle L. Santee, Jens-Uwe Grooß, et al. "Unusual chlorine partitioning in the 2015/16 Arctic winter lowermost stratosphere: observations and simulations." Atmospheric Chemistry and Physics 19, no. 12 (2019): 8311–38. http://dx.doi.org/10.5194/acp-19-8311-2019.

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Abstract. The Arctic winter 2015/16 was characterized by cold stratospheric temperatures. Here we present a comprehensive view of the temporal evolution of chlorine in the lowermost stratosphere over the course of the studied winter. We utilize two-dimensional vertical cross sections of ozone (O3) and chlorine nitrate (ClONO2), measured by the airborne limb imager GLORIA (Gimballed Limb Observer for Radiance Imaging of the Atmosphere) during the POLSTRACC/GW-LCYCLE II/GWEX/SALSA campaigns, to investigate the tropopause region in detail. Observations from three long-distance flights in January,

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Peters, Douglas, Victoria A. Vardell, Gliceida Galarza Fortuna, et al. "Relapsed and Refractory Multiple Myeloma with Pleural Involvement: A Case Series." Blood 142, Supplement 1 (2023): 6630. http://dx.doi.org/10.1182/blood-2023-179287.

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Introduction. Development of novel treatments and immunotherapeutics continue to improve outcomes in patients with multiple myeloma (MM), especially in those patients with standard and intermediate risk disease; patients with high-risk disease continue to have dismal outcomes. Secondary extramedullary disease (sEMD) is a high-risk disease feature associated with an expected survival less than one year (Zanwar, AJH, 2023). Detailed description of patients presenting with sEMD involving the pleural has not been previously published. In the present project, we aimed to identify and characterize t

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Kirmani, Sayyied J., Mark Middleton, Andreas Fontalis, Raka Srivastava, and Feroz Dinah. "Blood loss following medial unicondylar knee replacements without a tourniquet: is there a need to group and save?" International Journal of Research in Orthopaedics 5, no. 1 (2018): 65. http://dx.doi.org/10.18203/issn.2455-4510.intjresorthop20185074.

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<p class="abstract"><strong>Background:</strong> There are current trends towards not using a tourniquet in total knee replacement (TKR), but there is nothing published on what the effects of not using a tourniquet on unicondylar knee replacements (UKR) may be in terms of blood loss.</p><p class="abstract"><strong>Methods:</strong> A retrospective case series of 36 consecutive UKR from our institution were analysed. All procedures were carried out without a tourniquet and also utilised a standardised interventions protocol including withholding of anti

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Ferraz, Janaynna De Moura, and Mauro Luis Iasi. "A relação entre a técnica e a política: luta de classes em “o homem que via o futuro do lixo”/The relationship between technique and politics: class struggle in “the man who saw the future of garbage”." Revista Interinstitucional Brasileira de Terapia Ocupacional - REVISBRATO 6, no. 4 (2022): 1245–50. http://dx.doi.org/10.47222/2526-3544.rbto54126.

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Objetivo: Refletir acerca da relação indissociável, embora pouco explícita, entre o domínio da técnica e as implicações políticas nas atividades profissionais, mais especificamente, a partir da tensão entre saúde pública e a luta de classes. Descrição da imagem: Trata-se da charge 32 da série “O homem que via o futuro do lixo”, do professor Mauro Iasi, que ilustra uma profissional de saúde – diante do contexto da pandemia da Covid-19 – preocupada com o futuro, mas é alertada: não depende apenas do esforço aplicado, mas correlação de forças.Palavras-chave: Técnica. Política.Terapia ocupacional/

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Martin, Danick M., Brandon Hannay, Alexis Martin, Vanessa Veilleux, Nicholas Finn, and Gilles A. Robichaud. "Abstract 3812: Circular RNAs from the PAX5 oncogene are overexpressed in B-cell malignancies and modulate cancer processes." Cancer Research 83, no. 7_Supplement (2023): 3812. http://dx.doi.org/10.1158/1538-7445.am2023-3812.

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Abstract Circular RNAs (circRNAs) represent a new class of gene products involved in many biological processes. Due to their ability to bind and modulate co-interacting proteins and microRNAs (miRs), circRNAs represent new signaling mediators in cell biology and cancer processes. Recently, we identified circRNAs from the PAX5 oncogene (circPAX5) in B-cells. Given that PAX5 gene products are well established as potent oncogenic regulators of B-cell cancer lesions, we hypothesized that circPAX5 may also be potentially involved in pathogenic processes of B-cell malignancies. In this study, we wan

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Kleinpeter, Alex B., and Eric O. Freed. "HIV-1 Maturation: Lessons Learned from Inhibitors." Viruses 12, no. 9 (2020): 940. http://dx.doi.org/10.3390/v12090940.

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Since the emergence of HIV and AIDS in the early 1980s, the development of safe and effective therapies has accompanied a massive increase in our understanding of the fundamental processes that drive HIV biology. As basic HIV research has informed the development of novel therapies, HIV inhibitors have been used as probes for investigating basic mechanisms of HIV-1 replication, transmission, and pathogenesis. This positive feedback cycle has led to the development of highly effective combination antiretroviral therapy (cART), which has helped stall the progression to AIDS, prolong lives, and r

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Hohlfeld, R., B. Conti-Tronconi, I. Kalies, J. Bertrams, and K. V. Toyka. "Genetic restriction of autoreactive acetylcholine receptor-specific T lymphocytes in myasthenia gravis." Journal of Immunology 135, no. 4 (1985): 2393–99. http://dx.doi.org/10.4049/jimmunol.135.4.2393.

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Abstract Human autoreactive helper T lymphocytes with specificity for acetylcholine receptor (AChR) were isolated from three HLA-DR3-positive patients who had myasthenia gravis (MG), an autoimmune disease known to be associated with HLA-DR3 in the North European population. The antigen-specific T cells were evaluated for genetic restriction. Antigen presentation studies were performed with mitomycin C-treated accessory cells from a panel of HLA-typed unrelated donors. AChR-induced proliferation of the autoreactive T cells was maximal in the presence of autologous or HLA-DR-compatible antigen-p

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Brauer, David J., Frank Bitterer, Frank Dörrenbach, et al. "Synthese, Koordinationschemie und Ligandeneigenschaften sekundärer Phosphane R(Ar*)PH mit sperrigen aromatischen Resten - Molekülstruktur von Ph(2,4,6-iPr3C6H2)PH, (2,4,6-iPr3C6H2)2PH und ClAu[PhP(2,4,6-Bu3C6H2)H] / Synthesis, Coordination Chemistry and Ligand Properties of Secondary Phosphines R(Ar*)PH with Bulky Aromatic Substituents - Molecular Structure of Ph(2,4,6-iPr3C6H2)PH, (2,4,6-iPr3C6H2)2PH and ClAu[PhP(2,4,6-tBu3C6H2)H]." Zeitschrift für Naturforschung B 51, no. 8 (1996): 1183–96. http://dx.doi.org/10.1515/znb-1996-0819.

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The secondary phosphines R(Ar*)PH(R = Me, iPr, Ph, Mes, Ar*) (2a-2h) with bulky aromatic substituents Ar* (Ar* = 2,3,6-R′ 3C6H2, R′ = iPr, tBu) are obtained in good yields by reaction of RPCl2, PCl3, PBr3 or Ar*P(Cl, Br)2 with 2,4,6-tBu3C6H2Li or 2,4,6- iPr3C6H2MgBr and subsequent reduction of the intermediate halophosphines R(Ar*)PX(X = Cl, Br) with LiAlH4. The X-ray structural analysis of Ph(2,4,6-iPr3C6H2)PH (2g), space group P1, shows P-C-distances of 1.824(1) and 1.838(1)Å. The lithium derivatives of 2a-2c are monomeric in solution as indicated by the 1 :1 :1 : 1-quartet 7L i - 31P fine s

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