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Artículos de revistas sobre el tema "Multi-organ-on-chip"

Autor: Grafiati
Publicado: 25 de mayo de 2024

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1

Zuchowska, Agnieszka, and Sandra Skorupska. "Multi-organ-on-chip approach in cancer research." Organs-on-a-Chip 4 (December 2022): 100014. http://dx.doi.org/10.1016/j.ooc.2021.100014.

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2

Lungu, Iulia Ioana, and Alexandru Mihai Grumezescu. "Microfluidics – Organ-on-chip." Biomedical Engineering International 1, no. 1 (2019): 2–8. http://dx.doi.org/10.33263/biomed11.002008.

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This review is an introduction into the world of organ-on-chip models. By briefly explaining the concept of microfluidics and ‘lab-on-chip’, the main focus is on organs-on-chip and body-on-a-chip. The usual method to test the toxicity of a drug is through animal testing. However, the results do not always correlate to humans. In order to avoid animal testing, but also attain useful results, human-derived cell cultures using microfluidics have gained attention. Among all the different types of organ-on-chip devices, this review focuses on three distinct organs: heart, skin and liver. The main r
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3

Palaninathan, Vivekanandan, Vimal Kumar, Toru Maekawa, et al. "Multi-organ on a chip for personalized precision medicine." MRS Communications 8, no. 03 (2018): 652–67. http://dx.doi.org/10.1557/mrc.2018.148.

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4

Kim, Jinyoung, Junghoon Kim, Yoonhee Jin, and Seung-Woo Cho. "In situ biosensing technologies for an organ-on-a-chip." Biofabrication 15, no. 4 (2023): 042002. http://dx.doi.org/10.1088/1758-5090/aceaae.

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Abstract The in vitro simulation of organs resolves the accuracy, ethical, and cost challenges accompanying in vivo experiments. Organoids and organs-on-chips have been developed to model the in vitro, real-time biological and physiological features of organs. Numerous studies have deployed these systems to assess the in vitro, real-time responses of an organ to external stimuli. Particularly, organs-on-chips can be most efficiently employed in pharmaceutical drug development to predict the responses of organs before approving such drugs. Furthermore, multi-organ-on-a-chip systems facilitate t
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5

Vivas, Aisen, Albert van den Berg, Robert Passier, Mathieu Odijk, and Andries D. van der Meer. "Fluidic circuit board with modular sensor and valves enables stand-alone, tubeless microfluidic flow control in organs-on-chips." Lab on a Chip 22, no. 6 (2022): 1231–43. http://dx.doi.org/10.1039/d1lc00999k.

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Translational Organ-on-Chip Platform (TOP) is a multi-institutional effort to develop an open platform for automated organ-on-chip culture that actively facilitates the integration of components from various developers.
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6

Satoh, T., S. Sugiura, K. Shin, et al. "A multi-throughput multi-organ-on-a-chip system on a plate formatted pneumatic pressure-driven medium circulation platform." Lab on a Chip 18, no. 1 (2018): 115–25. http://dx.doi.org/10.1039/c7lc00952f.

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7

Boeri, Lucia, Luca Izzo, Lorenzo Sardelli, Marta Tunesi, Diego Albani, and Carmen Giordano. "Advanced Organ-on-a-Chip Devices to Investigate Liver Multi-Organ Communication: Focus on Gut, Microbiota and Brain." Bioengineering 6, no. 4 (2019): 91. http://dx.doi.org/10.3390/bioengineering6040091.

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The liver is a key organ that can communicate with many other districts of the human body. In the last few decades, much interest has focused on the interaction between the liver and the gut microbiota, with their reciprocal influence on biosynthesis pathways and the integrity the intestinal epithelial barrier. Dysbiosis or liver disorders lead to0 epithelial barrier dysfunction, altering membrane permeability to toxins. Clinical and experimental evidence shows that the permeability hence the delivery of neurotoxins such as LPS, ammonia and salsolinol contribute to neurological disorders. Thes
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8

Loskill, Peter, Thiagarajan Sezhian, Kevin M. Tharp, et al. "WAT-on-a-chip: a physiologically relevant microfluidic system incorporating white adipose tissue." Lab on a Chip 17, no. 9 (2017): 1645–54. http://dx.doi.org/10.1039/c6lc01590e.

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9

Zhao, Yi, Ranjith Kankala, Shi-Bin Wang, and Ai-Zheng Chen. "Multi-Organs-on-Chips: Towards Long-Term Biomedical Investigations." Molecules 24, no. 4 (2019): 675. http://dx.doi.org/10.3390/molecules24040675.

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With advantageous features such as minimizing the cost, time, and sample size requirements, organ-on-a-chip (OOC) systems have garnered enormous interest from researchers for their ability for real-time monitoring of physical parameters by mimicking the in vivo microenvironment and the precise responses of xenobiotics, i.e., drug efficacy and toxicity over conventional two-dimensional (2D) and three-dimensional (3D) cell cultures, as well as animal models. Recent advancements of OOC systems have evidenced the fabrication of ‘multi-organ-on-chip’ (MOC) models, which connect separated organ cham
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10

Sun, Qiyue, Jianghua Pei, Qinyu Li, Kai Niu, and Xiaolin Wang. "Reusable Standardized Universal Interface Module (RSUIM) for Generic Organ-on-a-Chip Applications." Micromachines 10, no. 12 (2019): 849. http://dx.doi.org/10.3390/mi10120849.

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The modular-based multi-organ-on-a-chip enables more stable and flexible configuration to better mimic the complex biological phenomena for versatile biomedical applications. However, the existing magnetic-based interconnection modes are mainly realized by directly embedding and/or fixing magnets into the modular microfluidic devices for single use only, which will inevitably increase the complexity and cost during the manufacturing process. Here, we present a novel design of a reusable standardized universal interface module (RSUIM), which is highly suitable for generic organ-on-chip applicat
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11

Huang, Ngan F., Ovijit Chaudhuri, Patrick Cahan, et al. "Multi-scale cellular engineering: From molecules to organ-on-a-chip." APL Bioengineering 4, no. 1 (2020): 010906. http://dx.doi.org/10.1063/1.5129788.

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12

Goldstein, Yoel, Sarah Spitz, Keren Turjeman, et al. "Breaking the Third Wall: Implementing 3D-Printing Techniques to Expand the Complexity and Abilities of Multi-Organ-on-a-Chip Devices." Micromachines 12, no. 6 (2021): 627. http://dx.doi.org/10.3390/mi12060627.

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The understanding that systemic context and tissue crosstalk are essential keys for bridging the gap between in vitro models and in vivo conditions led to a growing effort in the last decade to develop advanced multi-organ-on-a-chip devices. However, many of the proposed devices have failed to implement the means to allow for conditions tailored to each organ individually, a crucial aspect in cell functionality. Here, we present two 3D-print-based fabrication methods for a generic multi-organ-on-a-chip device: One with a PDMS microfluidic core unit and one based on 3D-printed units. The device
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13

Sung, Jong Hwan. "Multi-organ-on-a-chip for pharmacokinetics and toxicokinetic study of drugs." Expert Opinion on Drug Metabolism & Toxicology 17, no. 8 (2021): 969–86. http://dx.doi.org/10.1080/17425255.2021.1908996.

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14

Dehne, Eva-Maria, Tobias Hasenberg, Reyk Horland, and Uwe Marx. "Multi-organ on a chip: Human physiology-based assessment of liver toxicity." Toxicology Letters 280 (October 2017): S75. http://dx.doi.org/10.1016/j.toxlet.2017.07.192.

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15

Morais, Ana Sofia, Maria Mendes, Marta Agostinho Cordeiro, et al. "Organ-on-a-Chip: Ubi sumus? Fundamentals and Design Aspects." Pharmaceutics 16, no. 5 (2024): 615. http://dx.doi.org/10.3390/pharmaceutics16050615.

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This review outlines the evolutionary journey from traditional two-dimensional (2D) cell culture to the revolutionary field of organ-on-a-chip technology. Organ-on-a-chip technology integrates microfluidic systems to mimic the complex physiological environments of human organs, surpassing the limitations of conventional 2D cultures. This evolution has opened new possibilities for understanding cell–cell interactions, cellular responses, drug screening, and disease modeling. However, the design and manufacture of microchips significantly influence their functionality, reliability, and applicabi
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16

Baert, Y., I. Ruetschle, W. Cools, et al. "A multi-organ-chip co-culture of liver and testis equivalents: a first step toward a systemic male reprotoxicity model." Human Reproduction 35, no. 5 (2020): 1029–44. http://dx.doi.org/10.1093/humrep/deaa057.

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Abstract STUDY QUESTION Is it possible to co-culture and functionally link human liver and testis equivalents in the combined medium circuit of a multi-organ chip? SUMMARY ANSWER Multi-organ-chip co-cultures of human liver and testis equivalents were maintained at a steady-state for at least 1 week and the co-cultures reproduced specific natural and drug-induced liver–testis systemic interactions. WHAT IS KNOWN ALREADY Current benchtop reprotoxicity models typically do not include hepatic metabolism and interactions of the liver–testis axis. However, these are important to study the biotransfo
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17

An, Fan, Yueyang Qu, Xianming Liu, Runtao Zhong, and Yong Luo. "Organ-on-a-Chip: New Platform for Biological Analysis." Analytical Chemistry Insights 10 (January 2015): ACI.S28905. http://dx.doi.org/10.4137/aci.s28905.

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Direct detection and analysis of biomolecules and cells in physiological microenvironment is urgently needed for fast evaluation of biology and pharmacy. The past several years have witnessed remarkable development opportunities in vitro organs and tissues models with multiple functions based on microfluidic devices, termed as “organ-on-a-chip”. Briefly speaking, it is a promising technology in rebuilding physiological functions of tissues and organs, featuring mammalian cell co-culture and artificial microenvironment created by microchannel networks. In this review, we summarized the advances
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18

Giampetruzzi, Lucia, Amilcare Barca, Flavio Casino, et al. "Multi-Sensors Integration in a Human Gut-On-Chip Platform." Proceedings 2, no. 13 (2018): 1022. http://dx.doi.org/10.3390/proceedings2131022.

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In the conventional culture systems in vitro, the challenging organoid approach have recently been overcome by the development of microfluidic Organ Chip models of human intestine. The potential future applications of Intestine-on-Chips in disease modelling, drug development and personalized medicine are leading research to identify and investigate limitations of modern chip-based systems and to focus the attention on the gut epithelium and its specific barrier function playing a significant role in many human disorders and diseases. In this paper, we propose and discuss the importance to impl
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19

Cecen, Berivan, Christina Karavasili, Mubashir Nazir, et al. "Multi-Organs-on-Chips for Testing Small-Molecule Drugs: Challenges and Perspectives." Pharmaceutics 13, no. 10 (2021): 1657. http://dx.doi.org/10.3390/pharmaceutics13101657.

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Organ-on-a-chip technology has been used in testing small-molecule drugs for screening potential therapeutics and regulatory protocols. The technology is expected to boost the development of novel therapies and accelerate the discovery of drug combinations in the coming years. This has led to the development of multi-organ-on-a-chip (MOC) for recapitulating various organs involved in the drug–body interactions. In this review, we discuss the current MOCs used in screening small-molecule drugs and then focus on the dynamic process of drug absorption, distribution, metabolism, and excretion. We
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20

Basak, Sayan. "Unlocking the future: converging multi-organ-on-a-chip on the current biomedical sciences." Emergent Materials 3, no. 5 (2020): 693–709. http://dx.doi.org/10.1007/s42247-020-00124-y.

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21

Kim, Gyeong-Ji, Kwon-Jai Lee, Jeong-Woo Choi, and Jeung Hee An. "Drug Evaluation Based on a Multi-Channel Cell Chip with a Horizontal Co-Culture." International Journal of Molecular Sciences 22, no. 13 (2021): 6997. http://dx.doi.org/10.3390/ijms22136997.

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We developed a multi-channel cell chip containing a three-dimensional (3D) scaffold for horizontal co-culture and drug toxicity screening in multi-organ culture (human glioblastoma, cervical cancer, normal liver cells, and normal lung cells). The polydimethylsiloxane (PDMS) multi-channel cell chip (PMCCC) was based on fused deposition modeling (FDM) technology. The architecture of the PMCCC was an open-type cell chip and did not require a pump or syringe. We investigated cell proliferation and cytotoxicity by conducting 3-(4,5-dimethylthiazol-2-yl)-2,5-dphenyltetrazolium bromide (MTT) and lact
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22

Palama, E., M. Aiello, and S. Scaglione. "200P A novel multi-organ on chip model for metastatic tumor biology understanding." Immuno-Oncology and Technology 20 (December 2023): 100676. http://dx.doi.org/10.1016/j.iotech.2023.100676.

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23

Bovard, David, Anita Iskandar, Karsta Luettich, Julia Hoeng, and Manuel C. Peitsch. "Organs-on-a-chip." Toxicology Research and Application 1 (January 1, 2017): 239784731772635. http://dx.doi.org/10.1177/2397847317726351.

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In the last few years, considerable attention has been given to in vitro models in an attempt to reduce the use of animals and to decrease the rate of preclinical failure associated with the development of new drugs. Simple two-dimensional cultures grown in a dish are now frequently replaced by organotypic cultures with three-dimensional (3-D) architecture, which enables interactions between cells, promoting their differentiation and increasing their in vivo likeness. Microengineering now enables the incorporation of small devices into 3-D culture models to reproduce the complex microenvironme
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24

Dornhof, Johannes, Jochen Kieninger, Harshini Muralidharan, Jochen Maurer, Gerald A. Urban, and Andreas Weltin. "Microfluidic organ-on-chip system for multi-analyte monitoring of metabolites in 3D cell cultures." Lab on a Chip 22, no. 2 (2022): 225–39. http://dx.doi.org/10.1039/d1lc00689d.

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An organ-on-chip platform equipped with microsensors for long-term microfluidic cultivation and metabolic monitoring (O2, Glu, Lac) of 3D tumour organoid cultures grown from patient-derived single cancer stem cells.
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25

Fanizza, Francesca, Marzia Campanile, Gianluigi Forloni, Carmen Giordano, and Diego Albani. "Induced pluripotent stem cell-based organ-on-a-chip as personalized drug screening tools: A focus on neurodegenerative disorders." Journal of Tissue Engineering 13 (January 2022): 204173142210953. http://dx.doi.org/10.1177/20417314221095339.

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The Organ-on-a-Chip (OoC) technology shows great potential to revolutionize the drugs development pipeline by mimicking the physiological environment and functions of human organs. The translational value of OoC is further enhanced when combined with patient-specific induced pluripotent stem cells (iPSCs) to develop more realistic disease models, paving the way for the development of a new generation of patient-on-a-chip devices. iPSCs differentiation capacity leads to invaluable improvements in personalized medicine. Moreover, the connection of single-OoC into multi-OoC or body-on-a-chip allo
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26

Soragni, Camilla, Gwenaëlle Rabussier, Leon J. de Windt, Sebastian J. Trietsch, Henriëtte L. Lanz, and Chee P. Ng. "High throughput assay to quantify oxidative stress in organ-on-a-chip placenta models in a multi-chip platform." Placenta 112 (September 2021): e26. http://dx.doi.org/10.1016/j.placenta.2021.07.087.

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Imparato, Giorgia, Francesco Urciuolo, and Paolo Antonio Netti. "Organ on Chip Technology to Model Cancer Growth and Metastasis." Bioengineering 9, no. 1 (2022): 28. http://dx.doi.org/10.3390/bioengineering9010028.

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Organ on chip (OOC) has emerged as a major technological breakthrough and distinct model system revolutionizing biomedical research and drug discovery by recapitulating the crucial structural and functional complexity of human organs in vitro. OOC are rapidly emerging as powerful tools for oncology research. Indeed, Cancer on chip (COC) can ideally reproduce certain key aspects of the tumor microenvironment (TME), such as biochemical gradients and niche factors, dynamic cell–cell and cell–matrix interactions, and complex tissue structures composed of tumor and stromal cells. Here, we review th
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28

Wang, Ying I., Carlota Oleaga, Christopher J. Long, et al. "Self-contained, low-cost Body-on-a-Chip systems for drug development." Experimental Biology and Medicine 242, no. 17 (2017): 1701–13. http://dx.doi.org/10.1177/1535370217694101.

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Integrated multi-organ microphysiological systems are an evolving tool for preclinical evaluation of the potential toxicity and efficacy of drug candidates. Such systems, also known as Body-on-a-Chip devices, have a great potential to increase the successful conversion of drug candidates entering clinical trials into approved drugs. Systems, to be attractive for commercial adoption, need to be inexpensive, easy to operate, and give reproducible results. Further, the ability to measure functional responses, such as electrical activity, force generation, and barrier integrity of organ surrogates
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29

Zommiti, Mohamed, Nathalie Connil, Ali Tahrioui, et al. "Organs-on-Chips Platforms Are Everywhere: A Zoom on Biomedical Investigation." Bioengineering 9, no. 11 (2022): 646. http://dx.doi.org/10.3390/bioengineering9110646.

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Over the decades, conventional in vitro culture systems and animal models have been used to study physiology, nutrient or drug metabolisms including mechanical and physiopathological aspects. However, there is an urgent need for Integrated Testing Strategies (ITS) and more sophisticated platforms and devices to approach the real complexity of human physiology and provide reliable extrapolations for clinical investigations and personalized medicine. Organ-on-a-chip (OOC), also known as a microphysiological system, is a state-of-the-art microfluidic cell culture technology that sums up cells or
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30

Ribeiro, Mafalda, Pamela Ali, Benjamin Metcalfe, Despina Moschou, and Paulo R. F. Rocha. "Microfluidics Integration into Low-Noise Multi-Electrode Arrays." Micromachines 12, no. 6 (2021): 727. http://dx.doi.org/10.3390/mi12060727.

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Organ-on-Chip technology is commonly used as a tool to replace animal testing in drug development. Cells or tissues are cultured on a microchip to replicate organ-level functions, where measurements of the electrical activity can be taken to understand how the cell populations react to different drugs. Microfluidic structures are integrated in these devices to replicate more closely an in vivo microenvironment. Research has provided proof of principle that more accurate replications of the microenvironment result in better micro-physiological behaviour, which in turn results in a higher predic
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31

Shinha, Kenta, Wataru Nihei, Tatsuto Ono, Ryota Nakazato, and Hiroshi Kimura. "A pharmacokinetic–pharmacodynamic model based on multi-organ-on-a-chip for drug–drug interaction studies." Biomicrofluidics 14, no. 4 (2020): 044108. http://dx.doi.org/10.1063/5.0011545.

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32

Yen, Daniel P., Yuta Ando, and Keyue Shen. "A cost-effective micromilling platform for rapid prototyping of microdevices." TECHNOLOGY 04, no. 04 (2016): 234–39. http://dx.doi.org/10.1142/s2339547816200041.

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Micromilling has great potential in producing microdevices for lab-on-a-chip and organ-on-a-chip applications, but has remained under-utilized due to the high machinery costs and limited accessibility. In this paper, we assessed the machining capabilities of a low-cost 3-D mill in polycarbonate material, which were showcased by the production of microfluidic devices. The study demonstrates that this particular mill is well suited for the fabrication of multi-scale microdevices with feature sizes from micrometers to centimeters.
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33

Cameron, Tiffany C., Avineet Randhawa, Samantha M. Grist, et al. "PDMS Organ-On-Chip Design and Fabrication: Strategies for Improving Fluidic Integration and Chip Robustness of Rapidly Prototyped Microfluidic In Vitro Models." Micromachines 13, no. 10 (2022): 1573. http://dx.doi.org/10.3390/mi13101573.

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The PDMS-based microfluidic organ-on-chip platform represents an exciting paradigm that has enjoyed a rapid rise in popularity and adoption. A particularly promising element of this platform is its amenability to rapid manufacturing strategies, which can enable quick adaptations through iterative prototyping. These strategies, however, come with challenges; fluid flow, for example, a core principle of organs-on-chip and the physiology they aim to model, necessitates robust, leak-free channels for potentially long (multi-week) culture durations. In this report, we describe microfluidic chip fab
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Shanti, Aya, Bisan Samara, Amal Abdullah, et al. "Multi-Compartment 3D-Cultured Organ-on-a-Chip: Towards a Biomimetic Lymph Node for Drug Development." Pharmaceutics 12, no. 5 (2020): 464. http://dx.doi.org/10.3390/pharmaceutics12050464.

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The interaction of immune cells with drugs and/or with other cell types should be mechanistically investigated in order to reduce attrition of new drug development. However, they are currently only limited technologies that address this need. In our work, we developed initial but significant building blocks that enable such immune-drug studies. We developed a novel microfluidic platform replicating the Lymph Node (LN) microenvironment called LN-on-a-chip, starting from design all the way to microfabrication, characterization and validation in terms of architectural features, fluidics, cytocomp
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35

Abu-Dawas, Sadeq, Hawra Alawami, Mohammed Zourob, and Qasem Ramadan. "Design and Fabrication of Low-Cost Microfluidic Chips and Microfluidic Routing System for Reconfigurable Multi-(Organ-on-a-Chip) Assembly." Micromachines 12, no. 12 (2021): 1542. http://dx.doi.org/10.3390/mi12121542.

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A low-cost, versatile, and reconfigurable fluidic routing system and chip assembly have been fabricated and tested. The platform and its accessories were fabricated in-house without the need for costly and specialized equipment nor specific expertise. An agarose-based artificial membrane was integrated into the chips and employed to test the chip-to-chip communication in various configurations. Various chip assemblies were constructed and tested which demonstrate the versatile utility of the fluidic routing system that enables the custom design of the chip-to-chip communication and the possibi
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36

Lee, Hyuna, Dae Shik Kim, Sang Keun Ha, Inwook Choi, Jong Min Lee, and Jong Hwan Sung. "A pumpless multi-organ-on-a-chip (MOC) combined with a pharmacokinetic-pharmacodynamic (PK-PD) model." Biotechnology and Bioengineering 114, no. 2 (2016): 432–43. http://dx.doi.org/10.1002/bit.26087.

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Grigorev, Georgii V., Alexander V. Lebedev, Xiaohao Wang, Xiang Qian, George V. Maksimov, and Liwei Lin. "Advances in Microfluidics for Single Red Blood Cell Analysis." Biosensors 13, no. 1 (2023): 117. http://dx.doi.org/10.3390/bios13010117.

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The utilizations of microfluidic chips for single RBC (red blood cell) studies have attracted great interests in recent years to filter, trap, analyze, and release single erythrocytes for various applications. Researchers in this field have highlighted the vast potential in developing micro devices for industrial and academia usages, including lab-on-a-chip and organ-on-a-chip systems. This article critically reviews the current state-of-the-art and recent advances of microfluidics for single RBC analyses, including integrated sensors and microfluidic platforms for microscopic/tomographic/spec
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38

Safarzadeh, Melody, Lauren S. Richardson, Ananth Kumar Kammala, et al. "A multi-organ, feto-maternal interface organ-on-chip, models pregnancy pathology and is a useful preclinical extracellular vesicle drug trial platform." Extracellular Vesicle 3 (June 2024): 100035. http://dx.doi.org/10.1016/j.vesic.2024.100035.

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Tunesi, Marta, Luca Izzo, Ilaria Raimondi, Diego Albani, and Carmen Giordano. "A miniaturized hydrogel-based in vitro model for dynamic culturing of human cells overexpressing beta-amyloid precursor protein." Journal of Tissue Engineering 11 (January 2020): 204173142094563. http://dx.doi.org/10.1177/2041731420945633.

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Recent findings have highlighted an interconnection between intestinal microbiota and the brain, referred to as microbiota–gut–brain axis, and suggested that alterations in microbiota composition might affect brain functioning, also in Alzheimer’s disease. To investigate microbiota–gut–brain axis biochemical pathways, in this work we developed an innovative device to be used as modular unit in an engineered multi-organ-on-a-chip platform recapitulating in vitro the main players of the microbiota–gut–brain axis, and an innovative three-dimensional model of brain cells based on collagen/hyaluron
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40

Sticker, Drago, Mario Rothbauer, Sarah Lechner, Marie-Therese Hehenberger, and Peter Ertl. "Multi-layered, membrane-integrated microfluidics based on replica molding of a thiol–ene epoxy thermoset for organ-on-a-chip applications." Lab on a Chip 15, no. 24 (2015): 4542–54. http://dx.doi.org/10.1039/c5lc01028d.

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Prete, Alessandro, Antonio Matrone, and Roberto Plebani. "State of the Art in 3D Culture Models Applied to Thyroid Cancer." Medicina 60, no. 4 (2024): 520. http://dx.doi.org/10.3390/medicina60040520.

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Thyroid cancer (TC) is the prevalent endocrine tumor with a rising incidence, particularly in higher-income countries, leading to an increased interest in its management and treatment. While overall, survival rates for TC are usually favorable, advanced cases, especially with metastasis and specific histotypes, pose challenges with poorer outcomes, advocating the need of systemic treatments. Targeted therapies have shown efficacy in both preclinical models and clinical trials but face issues of resistance, since they usually induce partial and transient response. These resistance phenomena are
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42

van Berlo, Damiën, Evita van de Steeg, Hossein Eslami Amirabadi, and Rosalinde Masereeuw. "The potential of multi-organ-on-chip models for assessment of drug disposition as alternative to animal testing." Current Opinion in Toxicology 27 (September 2021): 8–17. http://dx.doi.org/10.1016/j.cotox.2021.05.001.

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Rajan, Shiny Amala Priya, Julio Aleman, MeiMei Wan, et al. "Probing prodrug metabolism and reciprocal toxicity with an integrated and humanized multi-tissue organ-on-a-chip platform." Acta Biomaterialia 106 (April 2020): 124–35. http://dx.doi.org/10.1016/j.actbio.2020.02.015.

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44

Konopka, Joanna, Dominik Kołodziejek, Magdalena Flont, Agnieszka Żuchowska, Elżbieta Jastrzębska, and Zbigniew Brzózka. "Exploring Endothelial Expansion on a Chip." Sensors 22, no. 23 (2022): 9414. http://dx.doi.org/10.3390/s22239414.

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Angiogenesis is the development of new blood vessels from the existing vasculature. Its malfunction leads to the development of cancers and cardiovascular diseases qualified by the WHO as a leading cause of death worldwide. A better understanding of mechanisms regulating physiological and pathological angiogenesis will potentially contribute to developing more effective treatments for those urgent issues. Therefore, the main goal of the following study was to design and manufacture an angiogenesis-on-a-chip microplatform, including cylindrical microvessels created by Viscous Finger Patterning
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45

Oleaga, Carlota, Anne Riu, Sandra Rothemund, et al. "Investigation of the effect of hepatic metabolism on off-target cardiotoxicity in a multi-organ human-on-a-chip system." Biomaterials 182 (November 2018): 176–90. http://dx.doi.org/10.1016/j.biomaterials.2018.07.062.

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46

Poloznikov, A. A. "MicroRNA Pattern of Culture Medium as a Substrate for the Analysis of Lysis of Cell Subpopulations in Multiorgan Cell Models." Biotekhnologiya 37, no. 2 (2021): 76–80. http://dx.doi.org/10.21519/0234-2758-2021-37-2-76-80.

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A method has been developed for assessing the proportion of lysed MDA-MB-231 cells cultured in the multi-organ human-on-a-chip model based on the determination of the hsa-miR-222-3p and hsa-miR-99b-5p microRNA levels in the culture medium. The threshold levels of microRNA expression were calculated, which made it possible to estimate the proportion of lysed cells with an accuracy of 25%. microRNA, breast cancer, cell model This work was supported by the Ministry of Education and Science of the Russian Federation (grant RFMEFI61618X0092).
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47

Fedi, Arianna, Chiara Vitale, Marco Fato, and Silvia Scaglione. "A Human Ovarian Tumor & Liver Organ-on-Chip for Simultaneous and More Predictive Toxo-Efficacy Assays." Bioengineering 10, no. 2 (2023): 270. http://dx.doi.org/10.3390/bioengineering10020270.

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In oncology, the poor success rate of clinical trials is becoming increasingly evident due to the weak predictability of preclinical assays, which either do not recapitulate the complexity of human tissues (i.e., in vitro tests) or reveal species-specific outcomes (i.e., animal testing). Therefore, the development of novel approaches is fundamental for better evaluating novel anti-cancer treatments. Here, a multicompartmental organ-on-chip (OOC) platform was adopted to fluidically connect 3D ovarian cancer tissues to hepatic cellular models and resemble the systemic cisplatin administration fo
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48

Safarzadeh, Melody, Lauren Richardson, Ananth Kumar Kammala, et al. "306 A multi-organ-on-chip model to study the efficacy of exosomal therapeutics in treating inflammation-associated adverse pregnancies." American Journal of Obstetrics and Gynecology 230, no. 1 (2024): S175. http://dx.doi.org/10.1016/j.ajog.2023.11.328.

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49

Safarzadeh, Melody, Lauren Richardson, Ananth Kumar Kammala, et al. "305 A multi-organ fetal membrane-placenta-on-chip platform to study the transmission of infection and inflammation during pregnancy." American Journal of Obstetrics and Gynecology 230, no. 1 (2024): S174—S175. http://dx.doi.org/10.1016/j.ajog.2023.11.327.

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50

Díaz Lantada, Andrés, Wilhelm Pfleging, Heino Besser, et al. "Research on the Methods for the Mass Production of Multi-Scale Organs-On-Chips." Polymers 10, no. 11 (2018): 1238. http://dx.doi.org/10.3390/polym10111238.

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The success of labs- and organs-on-chips as transformative technologies in the biomedical arena relies on our capacity of solving some current challenges related to their design, modeling, manufacturability, and usability. Among present needs for the industrial scalability and impact promotion of these bio-devices, their sustainable mass production constitutes a breakthrough for reaching the desired level of repeatability in systematic testing procedures based on labs- and organs-on-chips. The use of adequate biomaterials for cell-culture processes and the achievement of the multi-scale featur
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