Bibliografías temáticas / Nanocapsules – Toxicologie

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Literatura académica sobre el tema "Nanocapsules – Toxicologie"

Autor: Grafiati

Publicado: 30 de noviembre de 2024

Última modificación: 31 de julio de 2025

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Artículos de revistas sobre el tema "Nanocapsules – Toxicologie"

Chassot, Janaíne Micheli, Luana Mota Ferreira, Felipe Pereira Gomes, Letícia Cruz, and Leandro Tasso. "Stability-indicating RP-HPLC method for determination of beclomethasone dipropionate in nanocapsule suspensions." Brazilian Journal of Pharmaceutical Sciences 51, no. 4 (2015): 803–10. http://dx.doi.org/10.1590/s1984-82502015000400006.

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abstract A simple stability-indicating RP-HPLC/UV method was validated for determination of beclomethasone dipropionate (BD) in nanocapsule suspensions. Chromatographic conditions consisted of a RP C18column (250 mm x 4.60 mm, 5 µm, 110 Å), using methanol and water (85:15 v/v) as mobile phase at 1.0 mL/min with UV detection at 254 nm. The calibration curve was found to be linear in the concentration range of 5.0-25.0 µg/mL with a correlation coefficient > 0.999. Precision was demonstrated by a relative standard deviation lower than 2.0%. Accuracy was assessed by the recovery test of BD from

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Zielińska, Aleksandra, Filipa Carreiró, Ana M. Oliveira, et al. "Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology." Molecules 25, no. 16 (2020): 3731. http://dx.doi.org/10.3390/molecules25163731.

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Polymeric nanoparticles (NPs) are particles within the size range from 1 to 1000 nm and can be loaded with active compounds entrapped within or surface-adsorbed onto the polymeric core. The term “nanoparticle” stands for both nanocapsules and nanospheres, which are distinguished by the morphological structure. Polymeric NPs have shown great potential for targeted delivery of drugs for the treatment of several diseases. In this review, we discuss the most commonly used methods for the production and characterization of polymeric NPs, the association efficiency of the active compound to the poly

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Charlie-Silva, Ives, Natália Martins Feitosa, Juliana Moreira Mendonça Gomes, et al. "Potential of mucoadhesive nanocapsules in drug release and toxicology in zebrafish." PLOS ONE 15, no. 9 (2020): e0238823. http://dx.doi.org/10.1371/journal.pone.0238823.

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Bikash Medhi, Bikash Medhi, and Dr Swayamprava Dalai. "Polymeric Nanocapsules in Drug delivery." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 15, no. 4 (2022): 5933–35. http://dx.doi.org/10.37285/ijpsn.2022.15.4.1.

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The ever-increasing accomplishment of Nanotechnology in Science has raised the prospects of improving the properties and usability of an array of substances, minimizing the negative impact on human health as well as the environment. In the context of human health, continuous research is going on to obtain the maximum benefit of a pharmaceutical compound with a minimum dose by improving its delivery to the target site. Nanotechnology plays a key role in drug delivery providing target-oriented better therapeutic efficiency with minimal adverse effects. The widespread application potential of pol

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Bagale, Uday D., Shirish H. Sonawane, Bharat A. Bhanvase, Ravindra D. Kulkarni, and Parag R. Gogate. "Green synthesis of nanocapsules for self-healing anticorrosion coating using ultrasound-assisted approach." Green Processing and Synthesis 7, no. 2 (2018): 147–59. http://dx.doi.org/10.1515/gps-2016-0160.

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Abstract The present work deals with the production of nanocapsules containing a natural corrosion inhibition component. Azadirachta indica was encapsulated in urea-formaldehyde polymeric shell using ultrasound-assisted and conventional approaches of in situ polymerization. Subsequently nanocapsules were incorporated into clear epoxy polyamide to develop the green self-healing corrosion inhibition coating. The actual performance of the coating was evaluated based on the studies involving the repair of the crack of high solid surface coating. Corrosion inhibition of the healed area has been eva

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Bulcão, R. P., F. A. de Freitas, E. Dallegrave, et al. "Acute toxicological evaluation of lipid-core nanocapsules." Toxicology Letters 205 (August 2011): S287. http://dx.doi.org/10.1016/j.toxlet.2011.05.971.

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Bulcão, R. P., F. A. de Freitas, C. D. G. Venturini, et al. "Subchronic toxicological evaluation of lipid-core nanocapsules." Toxicology Letters 205 (August 2011): S287. http://dx.doi.org/10.1016/j.toxlet.2011.05.972.

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Mazzarino, Letícia, Ismael Casagrande Bellettini, Edson Minatti, and Elenara Lemos-Senna. "Development and validation of a fluorimetric method to determine curcumin in lipid and polymeric nanocapsule suspensions." Brazilian Journal of Pharmaceutical Sciences 46, no. 2 (2010): 219–26. http://dx.doi.org/10.1590/s1984-82502010000200008.

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A simple, rapid, and sensitive fluorimetric method was developed and validated to quantify curcumin in lipid and polymeric nanocapsule suspensions, using acetonitrile as a solvent. The excitation and emission wavelengths were set at 397 nm and 508 nm, respectively. The calibration graph was linear from 0.1 to 0.6 µg/mL with a correlation coefficient of 0.9982. The detection and quantitation limits were 0.03 and 0.10 µg/mL, respectively. The validation results confirmed that the developed method is specific, linear, accurate, and precise for its intended use. The current method was successfully

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Majda Benabbes, Aicha Fahri, Yassir El alaoui, Naoual Cherkaoui, Abdelkader Laatiris, and Younes Rahali. "Formulation of parenteral nutrition based on argan oil nanocapsule system using d-optimal mixture design." International Journal of Research in Pharmaceutical Sciences 11, no. 3 (2020): 3857–65. http://dx.doi.org/10.26452/ijrps.v11i3.2567.

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In parenteral nutrition, the lipid emulsions are usually presented separately from other components. The admixture is made just before or during administration because of limited stability. The purpose of the present study is the formulation of lipid nanocapsules (LNC) based on Argan-oil and their introduction into preparations for parenteral nutrition, then the evaluation of their stability. The lipid nanocapsules have been prepared according to the phase inversion temperature method. The experimental design was used to determine the feasibility of LNC with Argan oil (A.O.-LNC), the evaluatio

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Grandhi, Srikar, Moawia Al-Tabakha, and Prameela Rani Avula. "Enhancement of Liver Targetability through Statistical Optimization and Surface Modification of Biodegradable Nanocapsules Loaded with Lamivudine." Advances in Pharmacological and Pharmaceutical Sciences 2023 (November 18, 2023): 1–16. http://dx.doi.org/10.1155/2023/8902963.

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The intention of the current work was to develop and optimize the formulation of biodegradable polymeric nanocapsules for lamivudine (LMV) in order to obtain desired physical characteristics so as to have improved liver targetability. Nanocapsules were prepared in this study as aqueous-core nanocapsules (ACNs) with poly(lactide-co-glycolide) using a modified multiple emulsion technique. LMV was taken as a model drug to investigate the potential of ACNs developed in this work in achieving the liver targetability. Three formulations factors were chosen and 33 factorial design was adopted. The se

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Tesis sobre el tema "Nanocapsules – Toxicologie"

Huang, Zhiwei. "Élaboration de polymères dérivés du poly(acide malique) pour la vectorisation ciblée de principes actifs anticancéreux." Rennes, Ecole nationale supérieure de chimie, 2011. http://www.theses.fr/2011ENCR0001.

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Afin d’augmenter l’efficacité des principes actifs tout en diminuant leurs effets secondaires, beaucoup de recherches sont menées afin d’élaborer un vecteur permettant d’encapsuler des PAs et de les libérer à un endroit précis de l’organisme. Pour cela, il est nécessaire de concevoir un vecteur répondant à un cahier des charges strict. Le vecteur doit permettre le ciblage de la zone à traiter, être stable in vivo avant la libération du principe actif, biocompatible et non-toxique. Dans ce contexte, nous nous sommes donc fixés comme objectif de préparer et caractériser une famille de vecteurs n

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Delaporte, Flavien. "Évaluation de la toxicité des nanocapsules lipidiques sur des cellules hépatiques et immunitaires : influence de paramètres physico-chimiques." Electronic Thesis or Diss., Angers, 2024. https://dune.univ-angers.fr/documents/dune19058.

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Ce travail doctoral s’articule autour de l’étude de la biodistribution et la toxicité cellulaire de nanovecteurs : les nanocapsules lipidiques (NCLs). Les paramètres physico-chimiques (la taille, la charge et la pégylation) peuvent influencer les interactions cellulaires. Les NCLs possèdent un fort tropisme hépatique, ce qui a orienté les premiers travaux de recherche sur l’étude des interactions entre des NCLs de 50 et 100 nm et les hépatocytes, représentés par les cellules HepG2 et HepaRG. Une toxicité hépatique relativement faible,concentration, taille et temps dépendante a été démontrée. L

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Chen, Jaspe. "Nano-encapsulation de l’amiodarone dans des nanoparticules fonctionnelles pour le ciblage du myocarde et le traitement des arythmies cardiaques." Electronic Thesis or Diss., Angers, 2024. https://dune.univ-angers.fr/documents/dune19169.

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La fibrillation atriale est l’arythmie la plus fréquemment rencontrée et est devenue un enjeu de santé publique croissant. Bien que l’amiodarone soit la plus puissante des molécules antiarythmiques, elle est prescrite seulement en cas de contre-indication ou d’inefficacité des autres antiarythmiques. Son profil pharmacocinétique et son accumulation dans les tissus hautement perfusés et gras est associée à de nombreux effets indésirables lors de traitement chronique. Ainsi, son encapsulation dans des nanocapsules lipidiques fonctionnalisées représente une stratégie prometteuse pour cibler spéci

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Hureaux, José. "Nanocapsules lipidiques de paclitaxel et cancer bronchique : premières données d'efficacité et de toxicité chez la souris et méthodes d'aérosolisation à partir de lots précliniques." Phd thesis, Université d'Angers, 2009. http://tel.archives-ouvertes.fr/tel-00492820.

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Les nanocapsules lipidiques (NCL) sont une formulation sans solvant permettant d'encapsuler des principes actifs liposolubles comme le paclitaxel. Leurs propriétés sont : taille inférieure à 150 nanomètres (nm), concentration passive dans les tumeurs par effet « Enhanced Permeability and Retention » et inhibition de la glycoprotéine-P, impliquée dans un mécanisme de résistance au paclitaxel. Ce travail a d'abord étudié les adaptations à appliquer à la formulation usuelle des NCL de paclitaxel de 50 nm en vue de réaliser les premiers lots précliniques. Une méthode de conservation par congélatio

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