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Tesis sobre el tema "Nanoemulsion system"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 5 de febrero de 2022

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1

Si, Mengjie. "A Transferrin conjugated nanoemulsion system for brain delivery of antiretroviral therapy." Diss., Temple University Libraries, 2019. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/544948.

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Pharmaceutical Sciences<br>Ph.D.<br>HIV- associated neurocognitive disorder (HAND), also known as HIV encephalopathy and AIDS dementia, is one of the critical complications of HIV infection that causes severe morbidity and even shortens survival. This complication is challenging to treat because most of the antiretroviral therapeutic (ART) agents cannot achieve the desired therapeutic levels in the central nervous system (CNS) because they cannot efficiently cross the blood-brain barrier (BBB). The goal of this study is to develop a new transferrin conjugated nanoemulsion system (Tf-NE) for an

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2

Wan, Jing. "Fabrication and Characterization of Antifungal Essential Oil-in-Water Nanoemulsion Delivery System Targeting Fusarium Graminearum In Vitro and in Malting Barley." Diss., North Dakota State University, 2019. https://hdl.handle.net/10365/29756.

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Emerenciano, Denise Pofirio. "Obten??o de novos sistemas nanoautoemulsificantes a partir do ?leo das sementes de Azadirachta indica A Juss e suas aplica??es como inibidores de corros?o." Universidade Federal do Rio Grande do Norte, 2013. http://repositorio.ufrn.br:8080/jspui/handle/123456789/17708.

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Made available in DSpace on 2014-12-17T15:42:07Z (GMT). No. of bitstreams: 1 DenisePE_DISSERT.pdf: 2525598 bytes, checksum: 4ebddd4284264f39327feb8318f41699 (MD5) Previous issue date: 2013-01-21<br>Corrosion is a natural process that causes progressive deterioration of materials, so, reducing the corrosive effects is a major objective of development of scientific studies. In this work, the efficiency of corrosion inhibition on a AISI 1018 carbon steel of the nanoemulsion system containing the oil of the seeds of Azadirachta indica A. Juss (SNEOAI) was evaluated by the techniques of linear po

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4

Salvia, Trujillo Laura. "Nanoemulsions as delivery systems of food ingredients: Improving food safety and functionality." Doctoral thesis, Universitat de Lleida, 2014. http://hdl.handle.net/10803/134733.

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Les nanoemulsions es consideren una excel·lent manera d’incorporar compostos lipòfils actius en aliments degut a les seves propietats específiques. L’objectiu d’aquesta tesi fou estudiar els factors que afecten les propietats fisicoquímiques i de funcionalitat de les nanoemulsions com a portadores d’antimicrobians (olis essencials) o compostos bioactius (β-carotè). D’una banda, el mètode de fabricació i els paràmetres de processat, així com la concentració dels seus components i el tipus d’oli essencial van afectar significativament la mida de partícula de les nanoemulsions. Així, es van

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Rodrigues, Ciro Jos? Ferreira. "Estudo da efic?cia do tensoativo sorbitano tween 80 veiculado em nanoemuls?o contendo ?leo de soja, como inibidor de corros?o." Universidade Federal do Rio Grande do Norte, 2012. http://repositorio.ufrn.br:8080/jspui/handle/123456789/17700.

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Made available in DSpace on 2014-12-17T15:42:05Z (GMT). No. of bitstreams: 1 CiroJFR_DISSERT.pdf: 5688343 bytes, checksum: f082f764a617b016bd522ef00e0f6125 (MD5) Previous issue date: 2012-08-30<br>Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico<br>Nowadays, the use of chemicals that satisfactorily meet the needs of different sectors of the chemical industry is linked to the consumption of biodegradable materials. In this context, this work contemplated biotechnological aspects with the objective of developing a more environmentally-friendly corrosion inhibitor. In order to achi

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6

Ribes, Llop Susana. "Study of different antifungal systems to preserve strawberry jams against fungi spoilage." Doctoral thesis, Universitat Politècnica de València, 2017. http://hdl.handle.net/10251/82306.

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New tendencies in the development of innovative food packages could affect product microbial stability during storage. In this sense, antifungal systems such as emulsions, nanoemulsions and mesoporous silica supports, may be promising alternatives to preserve the product quality without having to apply further thermal treatments. The formulation of stable antifungal systems and the optimisation of the methodology to be employed to prepare these systems play an important role in: i) their antifungal effectiveness; ii) bioactive compounds losses during their preparation; and iii) their impact o

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7

Feitosa, Lorena Rolim. "Desenvolvimento de sistema autonanoemulsificante de ibuprofeno e avaliação do perfil de liberação in vitro." Niterói, 2017. https://app.uff.br/riuff/handle/1/3051.

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Submitted by Biblioteca da Faculdade de Farmácia (bff@ndc.uff.br) on 2017-03-14T17:58:37Z No. of bitstreams: 1 Feitosa, Lorena Rolim [Dissertação, 2015].pdf: 1298728 bytes, checksum: 4320200a78a4a14d77c8040a33f1d227 (MD5)<br>Made available in DSpace on 2017-03-14T17:58:37Z (GMT). No. of bitstreams: 1 Feitosa, Lorena Rolim [Dissertação, 2015].pdf: 1298728 bytes, checksum: 4320200a78a4a14d77c8040a33f1d227 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Os sistemas autoemulsificantes são misturas da fase oleosa, tensoativos e co-tensoativos, que após diluição em meio a

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8

Freitas, Sheila Cristina Monteiro Paiva. "Veiculação do quimioterápico paclitaxel em nanoemulsões lipídicas no tratamento da aterosclerose experimental: importância do tamanho das partículas da nanoemulsão." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5131/tde-04112016-124339/.

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INTRODUÇÃO: Sistemas nanométricos carreadores de fármacos, ao alcançarem a circulação sanguínea, se concentram em seus sítios de ação (\"drug-targeting\"), evitando tecidos saudáveis. O diâmetro médio e a polidispersidade de nanopartículas são parâmetros relevantes, pois podem influenciar no percurso pelo fluxo sanguíneo da partícula e na interação celular. A LDE, uma nanopartícula lipídica que mimetiza a lipoproteína de baixa densidade (LDL), é capaz de carrear fármacos como o quimioterápico paclitaxel para tecidos com alta taxa de proliferação celular, como por exemplo, lesões aterosclerótic

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9

Genta, Maria Luiza Nogueira Dias. ""Farmacocinética e captação tecidual do paclitaxel associado à nanoemulsão (LDE) em pacientes com neoplasias malignas do trato genital feminino"." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-24052006-163909/.

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O paclitaxel é utilizado amplamente no carcinoma de ovário, nos casos refratários de carcinoma de endométrio e quimioterapia exclusiva para carcinoma avançado de colo uterino. A associação de paclitaxel a uma nanoemulsião rica em colesterol, denominada LDE, mostrou toxicidade menor e aumento da atividade antitumoral do fármaco em cobaias. No presente estudo, investigou-se os parâmetros farmacocinéticos do oleato de LDE-paclitaxel e a habilidade da LDE de concentrar o fármaco no tumor em oito pacientes com câncer do trato genital feminino. O oleate de paclitaxel associado a LDE é estável na cir

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10

Dos, Santos Matos Ana Paula. "Development of micro and nanostructured systems for cutaneous leishmaniasis treatment." Thesis, Ecole nationale des Mines d'Albi-Carmaux, 2018. http://www.theses.fr/2018EMAC0021.

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La leishmaniose est une maladie négligée causée par des parasites protozoaires du genre Leishmania et affecte des millions de personnes dans plusieurs pays. Le traitement actuel pour la leishmaniose cutanée (LC) a de nombreux effets secondaires. Ces facteurs intensifient la recherche de nouvelles formulations et l’étude de différentes voies d’administration principalement pour le traitement LC, pour lesquelles les micro- et nanotechnologies pourraient représenter des solutions technologiques intéressantes capables de moduler le relargage ou la biodisponibilité des principes actifs. Un des médi

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11

Samarão, Filipa Rosa Lima Barros Afonso. "Novos sistemas terapêuticos para administração nasal de fármacos." Master's thesis, [s.n.], 2015. http://hdl.handle.net/10284/5315.

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Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas<br>A via de administração nasal de fármacos é uma via não invasiva e apresenta um elevado interesse devido às vantagens que possui relativamente a outras vias, tais como: previne o metabolismo hepático, a sua mucosa apresenta uma elevada área disponível para absorção, possui um epitélio fino e altamente vascularizado. Estas caraterísticas permitem obter uma elevada permeabilidade e uma rápida absorção dos fármacos administrados, pri

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12

Koot, Dwayne Jonathan. "Strategic pre-clinical development of Riminophenazines as resistance circumventing anticancer agents." Thesis, University of Pretoria, 2012. http://hdl.handle.net/2263/24163.

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Cancer is responsible for upward of 13% of human deaths. Contemporary chemotherapy of disseminated cancer is often thwarted by dose limiting systemic toxicity and by multi-drug resistance (MDR). Riminophenazines are a novel class of potential anticancer agents that possess a potent multi-mechanistic antineoplastic action. Apart from their broad action against intrinsic, non-classical resistance, Riminophenazines inhibit the action of Pgp and hypothetically all ABC transporters demonstrating their great utility against classical MDR. Considering that combination chemotherapy is the norm, the vi

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Walker, Rebecca M. "Fish Oil Nanoemulsions: Optimization of Physical and Chemical Stability for Food System Applications." 2016. https://scholarworks.umass.edu/masters_theses_2/313.

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Emulsion-based delivery systems offer many potential benefits for incorporating omega-3 oils into foods and beverages. Nanoemulsions are emulsion-based delivery systems that are gaining popularity because of their ease of preparation, small particle size, relatively high stability, high bioavailability, and production of optically transparent emulsions. Fish oil (FO) nanoemulsions are potentially more susceptible to lipid oxidation because of their high degree of lipid unsaturation, high surface area of exposed lipids, and greater light penetration. In the first study, spontaneous emulsificati

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Colmenares, Jose D. "Development of Nanoemulsion-based Delivery Systems for Evaluation of Triglycerides Bioactivity in Caernohabditis Elegans." 2015. https://scholarworks.umass.edu/masters_theses_2/267.

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Digestion and absorption of bioactive free fatty acids have been studied using the nematode Caernohabditis elegans (C. elegans). However, fatty acids mostly occur in foods in the form of triglycerides, which are highly hydrophobic molecules with low water-solubility, thereby making it difficult to study the fate of ingested fatty acids in C. elegans. The purpose of this research was to develop a method to deliver hydrophobic bioactives, including triglycerides, into C. elegans. Nanoemulsions containing triglyceride nanoparticles were prepared by sonication, and nanoparticle ingestion was confi

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Kadappan, Alagu Selvi. "The Efficacy of Nanoemulsion-Based Delivery Systems to Improve Vitamin D3 Bioaccessibility and Bioavailability." 2019. https://scholarworks.umass.edu/masters_theses_2/779.

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Vitamin D deficiency is an epidemic issue in all age groups in Western countries and that affects both skeletal and non-skeletal functions. Even with the wide application of food fortification, vitamin D deficiency tends to increase continuously. Being hydrophobic in nature, vitamin D has poor solubility; thereby it negatively affects its absorption and bioavailability when compared to other hydrophilic dietary compounds. The need to develop a novel strategy is of greater importance to enhance its bioavailability and thereby improving vitamin D level in the body. In this study, lipid-based del

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16

Ferreira, Ana Vanessa Fernandes. "Incorporation of elastase inhibitor in silk fibroin nanoparticles for transdermal delivery." Master's thesis, 2013. http://hdl.handle.net/1822/28648.

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Dissertação de mestrado em Bioengenharia<br>Human neutrophil elastase, as inflammatory response, has the capacity to degrade collagen and elastin component of extracellular matrix, being extensively involved in wrinkles formation induced by UV radiation damage. In order to develop a cosmetic antiwrinkling emulsion, we incorporated a potent synthetic HNE inhibitor, sivelestat (IC50 = 44 nM, Ki = 0.2 μM), into biopolymeric nanoparticles prepared by high-energy emulsification methods. As nanomaterial was used Bombyx mori silk fibroin protein, an FDA approved natural biocompatible and biodeg

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