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Artículos de revistas sobre el tema "Nanoemulsion system"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 5 de febrero de 2022

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1

Da Costa, Stephanie, Mahiran Basri, Norashikin Shamsudin, and Hamidon Basri. "Stability of Positively Charged Nanoemulsion Formulation Containing Steroidal Drug for Effective Transdermal Application." Journal of Chemistry 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/748680.

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This paper emphasizes the formation of a positively charged nanoemulsion system for steroid drugs (hydrocortisone). It is believed that positively charged nanoemulsion provides more effective penetration of the skin. Therefore in our study we focused on the incorporation of phytosphingosine which serves as a positively charged cosurfactant in the nanoemulsion system. Negatively charged nanoemulsions were formulated mainly for comparison. Freshly prepared formulations were formed with particle size less than 300 nm and showed good stability over time. The oil-in-water nanoemulsion also showed g

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Yukuyama, Megumi Nishitani, Edna Tomiko Myiake Kato, Raimar Lobenberg, and Nadia Araci Bou-Chacra. "Challenges and Future Prospects of Nanoemulsion as a Drug Delivery System." Current Pharmaceutical Design 23, no. 3 (2017): 495–508. http://dx.doi.org/10.2174/1381612822666161027111957.

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Nanoemulsion has the potential to overcome several disadvantages in drug formulation. Loading poor water-soluble drugs in the appropriate nanoemulsions enhances their wettability and/or solubility. Consequently, this improves their pharmacokinetics and pharmacodynamics by different routes of administration. Associated with the optimum nanodroplets size or even combined with key components, the droplets act as a reservoir of drugs, enabling nanoemulsion to be multifunctional platform to treat diverse diseases. A number of important advantages, which comprise nanoemulsion attributes, such as eff

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3

Nor Bainun, Ismail, Nur Hashimah Alias, and Syed Shatir A. Syed-Hassan. "Nanoemulsion: Formation, Characterization, Properties and Applications - A Review." Advanced Materials Research 1113 (July 2015): 147–52. http://dx.doi.org/10.4028/www.scientific.net/amr.1113.147.

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In this paper, the formation, characterizaton, properties and applications of nanoemulsions are reviewed and summarized. Nanoemulsions are under extensive investigation as it can aid to recover the residual oil from reservoir rock in Oil Recovery application because of the submicron sized emulsion. Nanoemulsion is thermodynamically or kinetically stable system in which two or more immiscible phases that is made up at least one phase dispersed in others by mechanical shearing with appropriate surfactants. Nanoemulsions possess stability against creaming or sedimentation due to their small parti

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Xiaoyan, Zheng, Zheng Lili, Sun Yaxin, et al. "Study on stability and in vitro digestion of camellia oil nanoemulsion system." E3S Web of Conferences 189 (2020): 02010. http://dx.doi.org/10.1051/e3sconf/202018902010.

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The soy protein isolate (SPI) was combined with tea saponin as an emulsifier to prepare camellia oil nanoemulsion, and the stability of camellia oil nanoemulsion was compared with that of soybean protein isolate or tea saponin as emulsifier. The effects of different pH, ionic strength, heating temperature and storage time on the average particle size, ξ-potential and microstructure of camellia oil nanoemulsion prepared by three emulsifiers were studied. The results showed that the nanoemulsions prepared by combining natural emulsifiers (SPI-TS) in the pH range of 5-9 were stable and remained s

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Zhao, Zhi-Juan, Xiao-Dong Cui, Xiao-Li Ma, and Zhuan-Hua Wang. "Formulation of a Self-Nanoemulsifying Drug Delivery System of Buckwheat Flavonoids and Evaluation of Its Antimicrobial Activity." Journal of Nanoscience and Nanotechnology 21, no. 5 (2021): 3050–58. http://dx.doi.org/10.1166/jnn.2021.19080.

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This study was aimed at constructing a self-nanoemulsifying drug delivery system of buckwheat flavonoids and evaluating its antimicrobial activity. The construction of the nanoemulsion followed a pseudo-ternary phase diagram, and its particle properties (particle size, zeta potential, and surface morphology) and physicochemical parameters (turbidity, surface tension, pH value, conductivity, encapsulation efficiency, and stability) were evaluated. The antimicrobial potential of buckwheat flavonoids nanoemulsion was determined against Staphylococcus aureus, Escherichia coli, and Candida albicans

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6

Medeiros, Arthur Sérgio Avelino de, Manoela Torres-Rêgo, Ariane Ferreira Lacerda, et al. "Self-Assembled Cationic-Covered Nanoemulsion as A Novel Biocompatible Immunoadjuvant for Antiserum Production Against Tityus serrulatus Scorpion Venom." Pharmaceutics 12, no. 10 (2020): 927. http://dx.doi.org/10.3390/pharmaceutics12100927.

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This study assesses the efficacy of different nanoemulsion formulations as new and innovative adjuvants for improving the in vivo immunization against the Tityus serrulatus scorpion venom. Nanoemulsions were designed testing key-variables such as surfactants, co-solvents, and the influence of the temperature, which would be able to induce the phase transition from a liquid crystal to a stable nanoemulsion, assessed for four months. Additionally, cationic-covered nanoemulsion with hyper-branched poly(ethyleneimine) was prepared and its performance was compared to the non-cationic ones. The phys

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7

Pratiwi, Liza, Achmad Fudholi, Ronny Martien, and Suwidjiyo Pramono. "Physical and Chemical Stability Test of SNEDDS (Self-nanoemulsifying Drug Delivery System) and Nanoemulsion Ethyl Acetate Fraction of Garcinia mangostana L." Majalah Obat Tradisional 23, no. 2 (2018): 84. http://dx.doi.org/10.22146/mot.28533.

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The mangosteen peels (Garcinia mangostana L.) has high free radical scavengers activity. This study aims to determine the physical and chemical conditions that are formulated in SNEDDS and nanoemulsion preparations. SNEDDS was made with various concentrations of Tween 80, PEG 400, and Virgin Coconut Oil (VCO) with a ratio of 4,98:1,02:1. Nanoemulsions were made with the addition of water to SNEDDS. Stability observation results were analyzed by statistics. The results of physical stability test show that all test samples in the research, in nanoemulsion, SNEDDS fraction, base SNEDDS, SNEDDS vi

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8

Daud, Nur Saadah, Musdalipah Musdalipah, and Asriyanti Lamadari. "FORMULASI NANOEMULSI ASPIRIN MENGGUNAKAN ETANOL 96 % SEBAGAI KO-SURFAKTAN." WARTA FARMASI 6, no. 1 (2017): 1–11. http://dx.doi.org/10.46356/wfarmasi.v6i1.66.

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ABSTRAK Aspirin termasuk dalam golongan Non Steroidal Anti Inflammatory Drugs (NSAIDs) yang banyak digunakan pada pengobatan nyeri ringan sampai sedang, antipiretik, anti inflamasi, serta anti koagulan. Pada penggunaan secara oral dapat menurunkan efektifitas obat akibat metabolisme lintas pertama. Alternatif untuk mengatasi masalah tersebut yaitu membuat sediaan topikal nanoemulsi aspirin. Nanoemulsi yaitu sistem emulsi yang transparan, tembus cahaya dan merupakan d ispersi minyak air yang distabilkan oleh lapisan film dari surfaktan dan ko-surfaktan, yang memiliki ukuran droplet 20 nm-

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9

Đoković, Jelena B., Sanela M. Savić, Jelena R. Mitrović, et al. "Curcumin Loaded PEGylated Nanoemulsions Designed for Maintained Antioxidant Effects and Improved Bioavailability: A Pilot Study on Rats." International Journal of Molecular Sciences 22, no. 15 (2021): 7991. http://dx.doi.org/10.3390/ijms22157991.

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The current study describes the experimental design guided development of PEGylated nanoemulsions as parenteral delivery systems for curcumin, a powerful antioxidant, as well as the evaluation of their physicochemical characteristics and antioxidant activity during the two years of storage. Experimental design setup helped development of nanoemulsion templates with critical quality attributes in line with parenteral application route. Curcumin-loaded nanoemulsions showed mean droplet size about 105 nm, polydispersity index <0.15, zeta potential of −40 mV, and acceptable osmolality of about

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Hobson, James J., Steve P. Rannard, Andrew Owen, and Neill J. Liptrott. "Safety assessment of a new nanoemulsion-based drug-delivery system reveals unexpected drug-free anticoagulant activity." Nanomedicine 15, no. 14 (2020): 1361–73. http://dx.doi.org/10.2217/nnm-2019-0447.

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Aim: A preclinical safety assessment of a novel nanoemulsion drug-delivery system, initially developed to improve the posology of efavirenz (EFV), was conducted with a specific focus on possible immunological and hematological complications. Materials & methods: Assessment of common acute toxicities, such as complement activation and cytokine secretion, was performed using validated assays known to have good correlation with in vivo end points. Results & conclusion: Compared with a standard aqueous solution of EFV, the EFV nanoemulsion showed no significant effect on immune cell functi

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11

Lucas, Cláudio Regis dos Santos, Yanne Katiussy Pereira Gurgel Aum, Edson de Andrade Araújo, et al. "Investigating the Fluid–Solid Interaction of Acid Nonionic Nanoemulsion with Carbonate Porous Media." Molecules 25, no. 6 (2020): 1475. http://dx.doi.org/10.3390/molecules25061475.

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The subject of rock–fluid interaction is important in cases where flow through porous media is occurring. One special case is when the fluid reacts with the porous matrix. In this case, the mass transfer and reaction rate control the dissolution pattern. This article aimed to study the interaction between an acid nanoemulsion system and a carbonate porous media. Nanoemulsions were developed to retard the rock’s dissolution and to promote the formation of conductivity channels. Nanoemulsions were prepared using ALK100 (alkyl alcohol ethoxylate) and RNX110 (alkylphenol ethoxylate) (nonionic surf

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12

Zhang, Bei, Miao Lei, Wenjing Huang, et al. "Improved Storage Properties and Cellular Uptake of Casticin-Loaded Nanoemulsions Stabilized by Whey Protein-Lactose Conjugate." Foods 10, no. 7 (2021): 1640. http://dx.doi.org/10.3390/foods10071640.

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Casticin has wide-ranging functional activities, but its water solubility is poor in food products. Here, a nanoemulsion stabilized by Maillard whey protein isolate conjugates (MWPI) was fabricated to encapsulate casticin. The nanoemulsion, with an average diameter of 200 nm, possessed the capability to load 700 μg/g casticin. MWPI-stabilized nanoemulsion showed better stability than that of the WPI nanoemulsion during 4 weeks of storage. Both the inhibition effects of the casticin-loaded nanoemulsion on cancer cells and the process of cellular uptake were studied. Results revealed that the ca

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13

Alobaidy, Rafid A. Rasool, Nawal A. Rajab, and Adawiya J. Haider. "Nanoemulsions Drug Delivery System: Preparations Techniques In Vitro Characterization and Pharmaceutical Application." Key Engineering Materials 886 (May 2021): 203–10. http://dx.doi.org/10.4028/www.scientific.net/kem.886.203.

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Nano-emulsions are a novel drug delivery system, in which mix two immiscible liquids, normally oil and water with the addition a proper surfactant and co-surfactant to obtain a single uniform phase, in many cases must be used more than one surfactant to improve the stability of nanoemulsion, in this survey consideration is focused to provide brief information about the formulation, a strategy of preparation, characterization procedure, evaluation parameter as particle size, polydispersity, drug content, zeta potential, and different application of nanoemulsion, it is thermodynamically unsteady

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14

Pandey, Parijat, Nisha Gulati, Manish Makhija, Deepika Purohit, and Harish Dureja. "Nanoemulsion: A Novel Drug Delivery Approach for Enhancement of Bioavailability." Recent Patents on Nanotechnology 14, no. 4 (2020): 276–93. http://dx.doi.org/10.2174/1872210514666200604145755.

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Background: Poor bioavailability and solubility of drugs in aqueous phase are the most important problems of newly developed chemical entities that can be improved by nanoemulsion. Objectives: BCS class II and IV which are poorly soluble in water demonstrate various problems in conventional dosage forms. For the improvement of solubility, bioavailability and getting the best therapeutic effect of poorly soluble drugs nanoemulsion is the best solution. Methods: Nanoemulsion are thermodynamically unstable isotropic system with droplet size 1-100 nm in which two immiscible fluids are combined tog

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15

Sarheed, Omar, Manar Dibi, Kanteti V. R. N. S. Ramesh, and Markus Drechsler. "Fabrication of Alginate-Based O/W Nanoemulsions for Transdermal Drug Delivery of Lidocaine: Influence of the Oil Phase and Surfactant." Molecules 26, no. 9 (2021): 2556. http://dx.doi.org/10.3390/molecules26092556.

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Transdermal drug delivery of lidocaine is a good choice for local anesthetic delivery. Microemulsions have shown great effectiveness for the transdermal transport of lidocaine. Oil-in-water nanoemulsions are particularly suitable for encapsulation of lipophilic molecules because of their ability to form stable and transparent delivery systems with good skin permeation. However, fabrication of nanoemulsions containing lidocaine to provide an extended local anesthetic effect is challenging. Hence, the aim of this study was to address this issue by employing alginate-based o/w nanocarriers using

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16

Tiwari, Sandip B., and Mansoor M. Amiji. "Improved Oral Delivery of Paclitaxel Following Administration in Nanoemulsion Formulations." Journal of Nanoscience and Nanotechnology 6, no. 9 (2006): 3215–21. http://dx.doi.org/10.1166/jnn.2006.440.

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Nanoemulsion formulations were designed for enhancing the oral bioavailability of hydrophobic drugs. Paclitaxel was selected as a model hydrophobic drug, which is also a substrate for the P-glycoprotein efflux system. The oil-in-water (o/w) nanoemulsions were formulated with pine nut oil as the internal oil phase, egg lecithin as the primary emulsifier, and water as the external phase. Stearylamine and deoxycholic acid were used to impart positive and negative charge to the emulsions, respectively. Nanoemulsions were prepared by sonication method and characterized for particle size and surface

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17

Bhosale, Rohit Rajendra, Riyaz Ali Osmani, Prasanna Prasad Ghodake, Sabir Majjid Shaikh, and Sarika Raghunath Chavan. "Nanoemulsion: A Review on Novel Profusion in Advanced Drug Delivery." Indian Journal of Pharmaceutical and Biological Research 2, no. 01 (2014): 122–27. http://dx.doi.org/10.30750/ijpbr.2.1.19.

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Nanoemulsions are submicron sized emulsion that is under extensive investigation as drug carriers for improving the delivery of therapeutic agents. These are by far the most advanced nanoparticle systems for the systemic delivery of active pharmaceutical for controlled drug delivery and targeting. These are the thermodynamically stable isotropic system in which two immiscible liquid (water and oil) are mixed to form a single phase by means of an appropriate surfactants or it mixes with a droplet diameter approximately in the range of 0.5-100 μm. Nanoemulsion droplet size falls typically in the

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18

PATHANIA, RUHI, HUMA KHAN, RAVINDER KAUSHIK, and MOHAMMED AZHAR KHAN. "Essential Oil Nanoemulsions and their Antimicrobial and Food Applications." Current Research in Nutrition and Food Science Journal 6, no. 3 (2018): 626–43. http://dx.doi.org/10.12944/crnfsj.6.3.05.

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The consumer awareness for secure insignificantly handled food has constrained the food dealers either to decrease the measure of chemically synthetic antimicrobial substances or to replace them with natural ones. Essential oils (EO) extracted from edible, therapeutic and herbal plants have been well recognized as natural antimicrobial additives. As characteristic then viable antimicrobials, EO have been progressively observed towards control of foodborne microbes and progression of nourishment wellbeing. It is ordinarily hard to achieve high antimicrobial vulnerability when mixing with EO in

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19

de Matos, Renata Prandini Adum, Marilia Freitas Calmon, Camila Fernanda Amantino, et al. "Effect of Curcumin-Nanoemulsion Associated with Photodynamic Therapy in Cervical Carcinoma Cell Lines." BioMed Research International 2018 (2018): 1–11. http://dx.doi.org/10.1155/2018/4057959.

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Cervical cancer is the fourth cause of cancer death in women. Curcumin has antineoplastic properties. Furthermore, curcumin may be used as a photosensitizing agent in Photodynamic Therapy. This study aimed to investigate the effects of Photodynamic Therapy in cellular viability using curcumin-nanoemulsion as a photosensitizing drug in cervical carcinoma cell lines. The empty nanoemulsion presented very low cytotoxicity in all cell lines analyzed. Additionally, the incubation with curcumin-nanoemulsion at 20 μM of curcumin showed more than 80% of cell viability for cell lines. Nanoemulsions wer

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Meng, Renzhou, Chengwen Wang, and Zhonghou Shen. "Optimization and Characterization of Highly Stable Nanoemulsion for Effective Oil-Based Drilling Fluid Removal." SPE Journal 25, no. 03 (2020): 1259–71. http://dx.doi.org/10.2118/199904-pa.

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Summary In this study, an oil-in-water nanoemulsion for the effective removal of an oil-based drilling fluid has been developed by means of the phase-inversion concentration method. The influence of four factors on the droplet size and removal efficiency were tested, including the mass ratio of mixed surfactants (Rm), the surfactant/oil ratio (SOR), the mass concentration of cosurfactant (cco), and the salinity of the saline solution (cs). Considering the application environment of displacement spacers, the long-term stability and temperature resistance were investigated. The results showed th

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Asmawi, Azren Aida, Norazlinaliza Salim, Emilia Abdulmalek, and Mohd Basyaruddin Abdul Rahman. "Modeling the Effect of Composition on Formation of Aerosolized Nanoemulsion System Encapsulating Docetaxel and Curcumin Using D-Optimal Mixture Experimental Design." International Journal of Molecular Sciences 21, no. 12 (2020): 4357. http://dx.doi.org/10.3390/ijms21124357.

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The synergistic anticancer effect of docetaxel (DTX) and curcumin (CCM) has emerged as an attractive therapeutic candidate for lung cancer treatment. However, the lack of optimal bioavailability because of high toxicity, low stability, and poor solubility has limited their clinical success. Given this, an aerosolized nanoemulsion system for pulmonary delivery is recommended to mitigate these drawbacks. In this study, DTX- and CCM-loaded nanoemulsions were optimized using the D-optimal mixture experimental design (MED). The effect of nanoemulsion compositions towards two response variables, nam

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Rekha, ND, Dattatri K. Nagesha, PH Rajasree, and N. Shruthi. "FORMULATION, CHARACTERIZATION AND EVALUATION OF ANTI-INFLAMMATORY AND ANTI-ANGIOGENIC ACTIVITIES OF MEMECYLAENE NANOEMULSION." Journal of Drug Delivery and Therapeutics 8, no. 5-s (2018): 126–31. http://dx.doi.org/10.22270/jddt.v8i5-s.1915.

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The present study was undertaken to formulate and evaluate the anti-inflammatory, anti-oxidant and anti-angiogenic activities of nanoemulsion of Memecylaene. Memecylaene was isolated from the leaves of Memecylon malabaricum by using various chromatographic methods. An oil-in-water (O/W) nanoemulsion of Memecylaene was formulated by sonication method using sunflower oil (oil phase), Tween 80 (Surfactant) and Ethanol (co-surfactant). The prepared nanoemulsion was characterized for its droplet size, poly dispersity index and zeta potential. Stability studies were performed and the nanoemulsions w

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Jesus, Flávia L. M., Fernanda B. de Almeida, Jonatas L. Duarte, et al. "Preparation of a Nanoemulsion with Carapa guianensis Aublet (Meliaceae) Oil by a Low-Energy/Solvent-Free Method and Evaluation of Its Preliminary Residual Larvicidal Activity." Evidence-Based Complementary and Alternative Medicine 2017 (2017): 1–8. http://dx.doi.org/10.1155/2017/6756793.

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Andiroba (Carapa guianensis) seeds are the source of an oil with a wide range of biological activities and ethnopharmacological uses. However, few studies have devoted attention to innovative formulations, including nanoemulsions. The present study aimed to obtain a colloidal system with the andiroba oil using a low-energy and organic-solvent-free method. Moreover, the preliminary residual larvicidal activity of the nanoemulsion against Aedes aegypti was evaluated. Oleic and palmitic acids were the major fatty acids, in addition to the phytosterol β-sitosterol and limonoids (tetranortriterpeno

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Barkat, Md A., Harshita, Md Rizwanullah, et al. "Therapeutic Nanoemulsion: Concept to Delivery." Current Pharmaceutical Design 26, no. 11 (2020): 1145–66. http://dx.doi.org/10.2174/1381612826666200317140600.

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: Nanoemulsions (NEs) or nanometric-scaled emulsions are transparent or translucent, optically isotropic and kinetically stable heterogeneous system of two different immiscible liquids namely, water and oil stabilized with an amphiphilic surfactant having droplet size ranges up to 100 nm. They offer a variety of potential interests for certain applications: improved deep-rooted stability; excellent optical clarity; and, enhanced bioavailability due to its nanoscale of particles. Though there is still comparatively narrow insight apropos design, development, and optimization of NEs, which mainl

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El-Refai, A. A., M. M. Rabie, Rania E. El-Gammal, and W. A. Al-Saban. "Nanoemulsion of Sesame Seeds Oil: Preparation, Evaluation and Stability." Asian Journal of Chemistry 31, no. 12 (2019): 3004–8. http://dx.doi.org/10.14233/ajchem.2019.22230.

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This work aims to study the effect of using nanoemulsion particles on the stability of sesame seed oil emulsion. During the roasting process of sesame seeds (Sohage-1), some physico-chemical properties of sesame seeds and its oil were determined. The moisture, protein and fiber contents were decreased whereas oil, ash and arbohydrates contents were increased. Sesame oil was extracted from roasted sesame seeds using mechanical pressing; some physico-chemical properties for extracted oil were determined. Results indicated that colour, acid value, free fatty acids (%), peroxide and hydrolysis val

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Poonsri, Orrawan, Wiyada Kwanhian, Apakorn Poltien, Piyatida Tangteerawatana, and Jitbanjong Tangpong. "Nanoemulsion Containing SangYod Rice Bran Oil and Thanakha Extracts: In Vitro Antioxidant and Irritation Assessments." Applied Mechanics and Materials 866 (June 2017): 3–7. http://dx.doi.org/10.4028/www.scientific.net/amm.866.3.

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Nanoemulsions are well characterized in a promising drug delivery system with applications for drug and cosmetic. Traditionally and cosmetic industries use Rice bran oil and Hesperethusa crenulata or Thanakha bark aqueous extract in sunscreen formulations, anti ageing products and in treatments for skin diseases. The aim of this study was to produce the nanoemulsion and to evaluate their physical stability, irritation potential. In vitro study, the total phenolic contents and total antioxidant capacity of SangYod Rice bran oil (SRBO) were 1130.44 ± 53.55 mg GAE/mg and 25.94±4.69 mmol TEAC/mg a

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Mulia, Kamarza, Rosalia M. A. Ramadhan, and Elsa A. Krisanti. "Formulation and characterization of nanoemulgel mangosteen extract in virgin coconut oil for topical formulation." MATEC Web of Conferences 156 (2018): 01013. http://dx.doi.org/10.1051/matecconf/201815601013.

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A hydrogel of nanoemulsion system containing mangosteen extract of mangosteen rind was developed and characterized for the purpose of topical formulation. Mangostins, the bioactive in the extract, has been known to have biological activities such as antifungal, antibacterial, antioxidant, antiviral and antitumoral. Due to the hydrophobic nature of mangostins, they can not to be directly formulated into a gel. Oil-in-water nanoemulsions were formulated of virgin coconut oil (VCO) as the oil phase and mixed surfactant consisting of Tween 80 and Span 80, using the high-speed homogenization method

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Sabjan, Khaleel Basha, Syed Muzammil Munawar, Dhandayuthabani Rajendiran, Sugantha Kumari Vinoji, and Kaviyarasu Kasinathan. "Nanoemulsion as Oral Drug Delivery - A Review." Current Drug Research Reviews 12, no. 1 (2020): 4–15. http://dx.doi.org/10.2174/2589977511666191024173508.

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Background: Objective:: The stability and delivery of drugs remain one of the key hurdles in the present situation. The present study depends on the design of a novel nanoemulsion drugdelivery system that would encapsulate a drug and to improve drug stability. The charisma of nanotechnology is majorly due to the smallest particle size at the nanoscale. Methods: Nanoemulsions attention is focused on emphasizing formulation aspect, method of preparation characterization techniques, evaluation parameters and various application of the nanoemulsions, several techniques to be used for the preparati

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Shah, Jigar, Anroop B. Nair, Shery Jacob, et al. "Nanoemulsion Based Vehicle for Effective Ocular Delivery of Moxifloxacin Using Experimental Design and Pharmacokinetic Study in Rabbits." Pharmaceutics 11, no. 5 (2019): 230. http://dx.doi.org/10.3390/pharmaceutics11050230.

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Nanoemulsion is one of the potential drug delivery strategies used in topical ocular therapy. The purpose of this study was to design and optimize a nanoemulsion-based system to improve therapeutic efficacy of moxifloxacin in ophthalmic delivery. Moxifloxacin nanoemulsions were prepared by testing their solubility in oil, surfactants, and cosurfactants. A pseudoternary phase diagram was constructed by titration technique and nanoemulsions were obtained with four component mixtures of Tween 80, Soluphor® P, ethyl oleate and water. An experiment with simplex lattice design was conducted to asses

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Uthumpa, Chutamas, Ratana Indranupakorn, and Rathapon Asasutjarit. "Development of Nanoemulsion Formulations of Ginger Extract." Advanced Materials Research 684 (April 2013): 12–15. http://dx.doi.org/10.4028/www.scientific.net/amr.684.12.

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The aim of the study was to enhance the stability of 6-gingerol, a major constituent in ginger extract, using nanoemulsion formulations. The effects of extraction techniques and solvents on the content of 6-gingerol in ginger powders were investigated. Assessments of three commonly used extraction techniques (maceration, sonication and soxhlet extraction) with two different extraction solvents (methanol and acetone) were used in this study. The highest of 6-gingerol content was obtained by using soxhlet extraction with acetone. Nanoemulsions were prepared from a mixture of oil phase (coconut o

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Chrastina, Adrian, Veronique T. Baron, Parisa Abedinpour, Gaelle Rondeau, John Welsh, and Per Borgström. "Plumbagin-Loaded Nanoemulsion Drug Delivery Formulation and Evaluation of Antiproliferative Effect on Prostate Cancer Cells." BioMed Research International 2018 (November 11, 2018): 1–7. http://dx.doi.org/10.1155/2018/9035452.

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Background. Plumbagin, a medicinal plant-derived 5-hydroxy-2-methyl-1,4-naphthoquinone, is an emerging drug with a variety of pharmacological effects, including potent anticancer activity. We have previously shown that plumbagin improves the efficacy of androgen deprivation therapy (ADT) in prostate cancer and it is now being evaluated in phase I clinical trial. However, the development of formulation of plumbagin as a compound with sparing solubility in water is challenging. Methods. We have formulated plumbagin-loaded nanoemulsion using pneumatically controlled high pressure homogenization o

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Chaudhari, Pallavi M., and Madhavi A. Kuchekar. "DEVELOPMENT AND EVALUATION OF NANOEMULSION AS A CARRIER FOR TOPICAL DELIVERY SYSTEM BY BOX-BEHNKEN DESIGN." Asian Journal of Pharmaceutical and Clinical Research 11, no. 8 (2018): 286. http://dx.doi.org/10.22159/ajpcr.2018.v11i8.26359.

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Objective: The aim of this study was to develop a nanoemulsion for topical delivery. Methods: Topical nanoemulsion was prepared by homogenization method. Box-behnken design was utilized to study the effect of oil, surfactant and Co-surfactant, on droplet size, entrapment efficiency and drug release. Nabumetone a non-steroidal anti-inflammatory drug was incorporated in castor oil with Tween 80 and Polyethylene glycol 600 to form the nanoemulsion by homogenization method. The nanoemulsion was further subjected to different evaluation parameters and ex-vivo study. The crystalline nature of drug w

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Khurana, Bharat, Daisy Arora, and RK Narang. "TOPICAL DELIVERY OF NANOEMULSION FOR ANTIPSORIATIC DRUGS." Journal of Drug Delivery and Therapeutics 8, no. 5-s (2018): 1–11. http://dx.doi.org/10.22270/jddt.v8i5-s.1914.

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Psoriasis is an autoimmune disorder of the skin characterized by relapsing episodes of inflammatory lesions and hyperkeratotic plaques with worldwide occurrence of around 2–5%. Psoriasis is a disease known to be caused by multitude of both genetic and environmental factors such as trauma, drugs, infection, alcohol, smoking and stress but its accurate origin is still not known. Further, available treatment options are associated with both inappropriate cosmetic appearance and related toxicities leading to poor patient compliance in long term use. Nanotechnology based drug delivery system has im

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Ningsih, Zubaidah, Maria Lucia A.D Lestari, and Salza Aprilia Rahma Maharin. "Preparation and Characterization of Curcumin Nanoemulsion in Olive Oil-Tween 80 System using Wet Ball Milling Method." ICS Physical Chemistry 1, no. 1 (2021): 16. http://dx.doi.org/10.34311/icspc.2021.1.1.16.

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Nanoemulsion has been developed as a drug delivery system which increases bioavailability and effectiveness of curcumin. Many methods and formulations have been applied in order to fabricate the most efficient nanoemulsion system to deliver curcumin. Wet ball milling is a simple technique to grind solids like powder to produce nano emulsion. On the other hand, a combination of olive oil and curcumin in Mediterranian Diet shows a promising anticancer activity. This research aims to elaborate the preparation and characterization of curcumin nanoemulsion in olive oil-Tween 80 system with wet ball

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Nabila, Najwa, Siti R. Hassan, Gladys P. Larasati, et al. "The Influence of Surface Charge on the Antiviral Effect of Curcumin Loaded in Nanocarrier System." Pharmaceutical Nanotechnology 9, no. 3 (2021): 210–16. http://dx.doi.org/10.2174/2211738509666210204121258.

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Background: Curcumin is a well-documented bioactive compound present in Curcuma sp., a tropical, medicinal plant. This substance exhibits broad-spectrum biological activities, including antivirus. Despite the lack of pharmaceutical properties of curcumin limits its clinical use. Objective: This study aims to produce curcumin nanoemulsion with different surface charge (curcumin (+) nanoemulsion and curcumin (-) nanoemulsion) and to evaluate its physical characteristics, in vitro cell cytotoxicity, and antiviral activity against dengue virus (DENV) 1 and 2. Methods: Two forms of nanoemulsion wer

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Zhao, Zhijuan, Xiaodong Cui, Xiaoli Ma, and Zhuanhua Wang. "Preparation, characterization, and evaluation of antioxidant activity and bioavailability of a self-nanoemulsifying drug delivery system (SNEDDS) for buckwheat flavonoids." Acta Biochimica et Biophysica Sinica 52, no. 11 (2020): 1265–74. http://dx.doi.org/10.1093/abbs/gmaa124.

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Abstract The self-nanoemulsifying drug delivery system has shown many advantages in drug delivery. In this study, a self-nanoemulsifying drug delivery system of buckwheat flavonoids was prepared for enhancing its antioxidant activity and oral bioavailability. A nanoemulsion of buckwheat flavonoids was developed and characterized, and its antioxidant, in vitro release, and in vivo bioavailability were determined. The nanoemulsion was optimized by the central composite design response surface experiment, and its particle size, polymer dispersity index (PDI), zeta potential, morphology, encapsula

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Upadhyay, Tanmay, Vaseem A. Ansari, Usama Ahmad, Nazneen Sultana, and Juber Akhtar. "Exploring Nanoemulsion for Liver Cancer Therapy." Current Cancer Therapy Reviews 16, no. 4 (2020): 260–68. http://dx.doi.org/10.2174/1573394716666200302123336.

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Cancer is a leading cause of mortality worldwide, accounting for 8.8 million deaths in 2015. Among these, at least 0.78 million people died of liver cancer alone. The recognized risk factors for liver cancer include chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, exposure to dietary aflatoxin, fatty liver disease, alcohol-induced cirrhosis, obesity, smoking, diabetes, and iron overload. The treatment plan for early diagnosed patients includes radiation therapy, tumour ablation, surgery, immunotherapy, and chemotherapy. Some sort of drug delivery vehicles has to be used w

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Arora, Ritika, Geeta Aggarwal, S. L. Harikumar, and Kirandeep Kaur. "Nanoemulsion Based Hydrogel for Enhanced Transdermal Delivery of Ketoprofen." Advances in Pharmaceutics 2014 (December 16, 2014): 1–12. http://dx.doi.org/10.1155/2014/468456.

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The aim of the present study was to investigate the nanoemulgel as transdermal delivery system for poorly water soluble drug, ketoprofen, in order to overcome the troubles associated with its oral delivery. Different nanoemulsion components (oil, surfactant, and cosurfactant) were selected on the basis of solubility and emulsification ability. Pseudoternary phase diagrams were constructed using titration method to figure out the concentration range of components. Carbomer 940 was added as gel matrix to convert nanoemulsion into nanoemulgel. Drug loaded nanoemulsions and nanoemulgels were chara

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Sun, Fu-Min, Yu-Jou Chou, Qingrong Huang, Jing-Yu Hu, and Yuwen Ting. "Making Concentrated Pterostilbene Highly Bioavailable in Pressure Processed Phospholipid Nanoemulsion." Processes 9, no. 2 (2021): 294. http://dx.doi.org/10.3390/pr9020294.

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Pterostilbene, a dimethylether analog of resveratrol, has been found to have potent biological activity. However, the bioavailability of pterostilbene in the biological system is limited due to its poor solubility in an aqueous environment. A nanoemulsion system was designed for this purpose. Lecithin-based nanoemulsion was formed after 3 cycles through a high-pressure homogenizer at 500 psi. The rheological properties and particle size were measured using dynamic light scattering and a viscometer. The storage stabilities of the prepared formulation were determined based on its ability to main

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Hammodi, Ihab D., and Shaimaa N. Abd Alhammid. "Preparation and Characterization of Topical Letrozole Nanoemulsion for Breast Cancer." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 29, no. 1 (2020): 195–206. http://dx.doi.org/10.31351/vol29iss1pp195-206.

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Letrozole (LZL) is a non-steroidal competitive aromatase enzyme system inhibitor. The aim of this study is to improve the permeation of LZL through the skin by preparing as nanoemulsion using various numbers of oils, surfactants and co-surfactant with deionized water. Based on solubility studies, mixtures of oleic acid oil and tween 80/ transcutol p as surfactant/co-surfactant (Smix) in different percentages were used to prepare nanoemulsions (NS). Therefore, 9 formulae of (o/w) LZL NS were formulated, then pseudo-ternary phase diagram was used as a useful tool to evaluate the NS domain at Smi

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Salim, Norazlinaliza, Noraini Ahmad, Siti Hajar Musa, Rauzah Hashim, Tharwat F. Tadros, and Mahiran Basri. "Nanoemulsion as a topical delivery system of antipsoriatic drugs." RSC Advances 6, no. 8 (2016): 6234–50. http://dx.doi.org/10.1039/c5ra14946k.

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Bayanati, Masoumeh, Abolfazl Ghafouri Khosroshahi, Maryam Alvandi, and Mohammad Mehdi Mahboobian. "Fabrication of a Thermosensitive In Situ Gel Nanoemulsion for Nose to Brain Delivery of Temozolomide." Journal of Nanomaterials 2021 (March 13, 2021): 1–11. http://dx.doi.org/10.1155/2021/1546798.

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In this study, a thermosensitive in situ gel nanoemulsion was formulated by a low energy method for intranasal delivery of temozolomide to bypass the blood-brain barrier and optimize chemotherapy for glioblastoma. Various amounts of Labrasol, Transcutol®P, and Triacetin were chosen as nanoemulsion components based on the solubility and the partial pseudoternary phase diagrams studies. Poloxamer derivatives added to the selected nanoemulsion and gelling temperature optimized. The prepared in situ gel nanoemulsion containing temozolomide showed a mean droplet size of 16.25 ± 0.44 nm , a polydisp

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Almaráz-Buendia, Isaac, Adriana Hernández-Escalona, Roberto González-Tenorio, et al. "Producing an Emulsified Meat System by Partially Substituting Pig Fat with Nanoemulsions that Contain Antioxidant Compounds: The Effect on Oxidative Stability, Nutritional Contribution, and Texture Profile." Foods 8, no. 9 (2019): 357. http://dx.doi.org/10.3390/foods8090357.

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The objective of this study was the incorporation of a water–oil (W/O) nanoemulsion for the partial substitution of pig fats and the addition of antioxidant compounds in an emulsified meat system (EMS). The nanoemulsion was formulated with orange essential oil and cactus acid fruit (xoconostle). The treatments were different percentages (0, 1, 2, 3, 4, and 5%) of the nanoemulsion for the substitution of pig fat in the EMS. The proximal analysis (moisture, protein, fat, and ash), texture profile (hardness, cohesiveness, springiness, and chewiness), phenolic compounds and antioxidant capacity 2,

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Karami, Zahra, Maryam Khoshkam, and Mehrdad Hamidi. "Optimization of Olive Oil-Based Nanoemulsion Preparation for Intravenous Drug Delivery." Drug Research 69, no. 05 (2018): 256–64. http://dx.doi.org/10.1055/a-0654-4867.

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AbstractA seven-factor Box-Behnken design was used for the optimized development of an olive oil-based nanoemulsion (NE) intended for intravenous drug delivery. The independent variables of olive oil concentration, tween 80 concentration, span 80 concentration, rate of adding of oil in aqueous phase, homogenization speed, homogenization time, and preparation temperature, were used as inputs of the factorial design. The response variables were mean droplet diameter, zeta potential (ZP), and polydispersity index (PDI). A quadratic, linear and 2FI model was established to predict the responses ba

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Gayathri K, Murugavel K, Karpagavel L, and Manikandan N. "A study to formulate the synthesis and characterization of mixed fruit juice nanoemulsion." International Journal of Research in Pharmaceutical Sciences 11, SPL4 (2020): 1118–23. http://dx.doi.org/10.26452/ijrps.v11ispl4.4252.

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An advanced mode of drug delivery system will overcome the major drawbacks associated with conventional drug delivery systems. Nanoemulsions are clear, thermodynamically stable mixtures of oil, water, surfactant and co-surfactant. These are the oil-in-water type of emulsions with the average droplet size ranging from 5 nm to 100 nm. Nanoemulsions are thermodynamically stable transparent or translucent dispersions of oil and water stabilized by an interfacial film of surfactant and co-surfactant molecules having a droplet size of less than 100 nm. Parameter that are to be used for its character

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Pagar, Kanchan R., and A. B. Darekar. "Nanoemulsion: A new concept of Delivery System." Asian Journal of Research in Pharmaceutical Science 9, no. 1 (2019): 39. http://dx.doi.org/10.5958/2231-5659.2019.00006.7.

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Sadeq, Zainab A. "Review on Nanoemulsion: Preparation and Evaluation." International Journal of Drug Delivery Technology 10, no. 01 (2020): 187–89. http://dx.doi.org/10.25258/ijddt.10.1.33.

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Nanoemulsion considers a novel drug delivery system that permits controlled or sustained drug release. It is a dispersion consisting of a surfactant, oil, and clear aqueous phase, kinetically, or thermodynamically stable with droplet diameter 10-100nm. Nanoemulsion applied to increase the solubility and bioavailability of lipophilic drugs; they have many advantages for drug delivery. There are many methods for Nanoemulsion preparation like High –energy emulsification method, Spontaneous Nanoemulsion, Phase inversion temperature (PIT). It applied for many routes of delivery, thus providing a pr

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Manyarara, Tapiwa E., Star Khoza, Admire Dube, and Chiedza C. Maponga. "Formulation and characterization of a paediatric nanoemulsion dosage form with modified oral drug delivery system for improved dissolution rate of nevirapine." MRS Advances 3, no. 37 (2018): 2203–19. http://dx.doi.org/10.1557/adv.2018.320.

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ABSTRACTBackground: The development of appropriate dosage forms for paediatric antiretroviral therapy is key for improved therapeutic outcomes in children. The focus of this study was to improve solubility, dissolution rate, drug release and maintain high drug permeability.Methodology: A nanoemulsion was prepared using emulsion inversion point and evaluated. The nanoemulsion had nevirapine (3% w/w). In vitro drug release studies were performed using dialysis membrane. Permeability studies using the Caco-2 cell model were performed for the formulation.Results: The optimized nevirapine nanoemuls

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Liu, Wenwen, Songzhu Cui, Jianhua Ji, Dejun Sun, and Tao Wu. "Utilization Phase Transition Component Method to Prepare Specially Functionalized Nanoemulsion by Adding Resveratrol/Phenethyl Resorcinol Mixed Active Components and Application in Free Radicals Removal." Journal of Nanoscience and Nanotechnology 20, no. 12 (2020): 7769–74. http://dx.doi.org/10.1166/jnn.2020.18607.

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To explore the possibility of using a specially functionalized nanoemulsion for the removal of free radical, resveratrol and phenethyl resorcinol were employed to form resveratrol/phenethyl resorcinol mixed active components, and the removal efficiency of free radicals was evaluated. Original nanoemulsion and specially functionalized-nanoemulsion were characterized by DLS and EPR. The free radical scavenging ability of the mixed active components of resveratrol/phenethyl resorcinol was determined as a function of the mass ratio of resveratrol to phenethyl resorcinol, temperature, and ionic str

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Hosny, Khaled M., Nabil A. Alhakamy, Amal M. Sindi, and Rasha A. Khallaf. "Coconut Oil Nanoemulsion Loaded with a Statin Hypolipidemic Drug for Management of Burns: Formulation and In Vivo Evaluation." Pharmaceutics 12, no. 11 (2020): 1061. http://dx.doi.org/10.3390/pharmaceutics12111061.

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Burn wound healing is a complex process that involves the repair of injured tissues and the control of infection to diminish the scar formation, pain, and discomfort associated with such injuries. The aim of this research was to formulate and optimize a self-nanoemulsion drug delivery system based on the use of coconut oil and loaded with simvastatin. Coconut oil possesses antiinflammatory and antibacterial activity, and simvastatin has interesting properties for promoting the wound-healing process because it increases the production of the vascular endothelial growth factor at the site of inj

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