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Artículos de revistas sobre el tema "Neisseri meningitidis serogroup B"

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Publicado: 14 de marzo de 2023

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1

Kepenekli Kadayifci, Eda, Deniz Güneşer Merdan, Ahmet Soysal, et al. "Prevalence of Neisseria meningitidis carriage: a small-scale survey in Istanbul, Turkey." Journal of Infection in Developing Countries 10, no. 04 (2016): 413–17. http://dx.doi.org/10.3855/jidc.7483.

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Introduction: The human nasopharynx is the main reservoir of Neisseria meningitidis, and asymptomatic carriage is common. N. meningitidis one of the common causes of bacterial meningitis in Turkey, especially after the implementation of the national immunization program that includes conjugated pneumococcal and Haemophilus influenzae type b vaccines. The purpose of this study was to evaluate the prevalence of meningococcal carriage and determine the leading serogroup, which may help authorities to adapt appropriate meningococal vaccine into the national immunization programme. Methodology: The
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HILSE, R., J. STOEVESANDT, D. A. CAUGANT, H. CLAUS, M. FROSCH, and U. VOGEL. "Distribution of the meningococcal insertion sequence IS1301 in clonal lineages of Neisseria meningitidis." Epidemiology and Infection 124, no. 2 (2000): 337–40. http://dx.doi.org/10.1017/s0950268899003647.

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The distribution of the meningococcal insertion sequence IS1301 was analysed in 496 strains of different serogroups and clonal lineages of Neisseria meningitidis, and in 64 neisserial strains other than N. meningitidis. IS1301 was found in meningococci, but not in apathogenic Neisseria sp. and Neisseria gonorrhoeae. The copy numbers of IS1301 varied between 2 and 17 per genome. IS1301 positive strains were mostly found among the serogroups 29E, W135, X, and Y. Clonal lineages of serogroup A, B, and C meningococci associated with epidemic meningococcal disease were rarely positive for IS1301.
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Kourna Hama, Mamadou, Dam Khan, Boubou Laouali, et al. "Pediatric Bacterial Meningitis Surveillance in Niger: Increased Importance of Neisseria meningitidis Serogroup C, and a Decrease in Streptococcus pneumoniae Following 13-Valent Pneumococcal Conjugate Vaccine Introduction." Clinical Infectious Diseases 69, Supplement_2 (2019): S133—S139. http://dx.doi.org/10.1093/cid/ciz598.

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Abstract Background Meningitis is endemic in Niger. Haemophilus influenzae type b (Hib) vaccine and the 13-valent pneumococcal conjugate vaccine (PCV13) were introduced in 2008 and 2014, respectively. Vaccination campaign against Neisseria meningitidis serogroup A was carried out in 2010–2011. We evaluated changes in pathogen distribution using data from hospital-based surveillance in Niger from 2010 through 2016. Methods Cerebrospinal fluid (CSF) specimens from children <5 years old with suspected meningitis were tested to detect vaccine-preventable bacterial pathogens. Confirmatory identi
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Wang, Quan, Zhujun Shao, Xiaoting Wang, et al. "Genetic Study of Capsular Switching between Neisseria meningitidis Sequence Type 7 Serogroup A and C Strains." Infection and Immunity 78, no. 9 (2010): 3883–88. http://dx.doi.org/10.1128/iai.00363-10.

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ABSTRACT Neisseria meningitidis is a leading cause of septicemia and meningitis worldwide. N. meningitidis capsular polysaccharides have been classified into 13 distinct serogroups which are defined by antibody reactivity and structural analysis, and the capsule plays an important role in virulence. Serogroups A, B, C, W135, and Y have been reported to be clinically important. Several newly identified serogroup C isolates belonging to the unique sequence type 7 (ST-7) were identified in China. Since most ST-7 isolates from China belonged to serogroup A, the newly identified ST-7 serogroup C st
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Abady, N. R., C. J. D. Guglielmino, R. M. Graham, et al. "Genetic characterization of a Neisseria meningitidis cluster in Queensland, Australia." Canadian Journal of Microbiology 63, no. 7 (2017): 644–47. http://dx.doi.org/10.1139/cjm-2017-0017.

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Neisseria meningitidis serogroups B and C have been responsible for the majority of invasive meningococcal disease in Australia, with serogroup B strains causing an increasing proportion of cases in recent years. Serogroup Y has typically caused sporadic disease in Australia. In 2002, a cluster of 4 cases was reported from a rural region in Queensland. Three of these cases were serogroup C, with 1 case diagnosed by molecular detection only, and the fourth case was identified as a serogroup Y infection. Genomic analysis, including antigen finetyping, multilocus sequence typing (MLST), and core
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Li, Yanwen, Yao-hui Sun, Cathy Ison, Myron M. Levine, and Christoph M. Tang. "Vaccination with Attenuated Neisseria meningitidis Strains Protects against Challenge with Live Meningococci." Infection and Immunity 72, no. 1 (2004): 345–51. http://dx.doi.org/10.1128/iai.72.1.345-351.2004.

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ABSTRACT Meningococcal disease is a life-threatening infection caused by Neisseria meningitidis. Currently, there are no vaccines to prevent infection with serogroup B N. meningitidis strains, the leading cause of meningococcal meningitis in Europe and North America. Here we describe the construction and characterization of two attenuated serogroup B N. meningitidis strains, YH102 (MC58Δsia ΔrfaF) and YH103 (MC58Δsia ΔmetH). Both strains are markedly attenuated in their capacity to cause bacteremia in rodent models and have a reduced ability to survive in a human whole-blood assay. Immunizatio
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Stabler, Richard A., Gemma L. Marsden, Adam A. Witney, et al. "Identification of pathogen-specific genes through microarray analysis of pathogenic and commensal Neisseria species." Microbiology 151, no. 9 (2005): 2907–22. http://dx.doi.org/10.1099/mic.0.28099-0.

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The release of the complete genome sequences of Neisseria meningitidis MC58 and Z2491 along with access to the sequences of N. meningitidis FAM18 and Neisseria gonorrhoeae FA1090 allowed the construction of a pan-Neisseria microarray, with every gene in all four genomes represented. The microarray was used to analyse a selection of strains including all N. meningitidis serogroups and commensal Neisseria species. For each strain, genes were defined as present, divergent or absent using gack analysis software. Comparison of the strains identified genes that were conserved within N. meningitidis
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Portilho, Amanda Izeli, Gabriela Trzewikoswki de Lima, and Elizabeth De Gaspari. "Neisseria meningitidis: analysis of pili and LPS in emerging Brazilian strains." Therapeutic Advances in Vaccines and Immunotherapy 8 (January 2020): 251513552091919. http://dx.doi.org/10.1177/2515135520919195.

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Background: Neisseria meningitidis is the main cause of bacterial meningitis in Brazil, where the main serogroups isolated are B and C; however, the serogroup W has recently emerged. LPS and type IV pili are important virulence factors that increase meningococci pathogenicity. Methods: The characterization of Lipopolysaccharide (LPS) and type IV pili in 19 meningococci strains of serogroup B, 21 of serogroup C, 45 of serogroup W and 28 of serogroup Y, isolated in Brazil between 2011 and 2017, was conducted using the Enzyme-linked Immunosorbent Assay (Dot- ELISA) technique and monoclonal antibo
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Ceyhan, Mehmet, Yasemin Ozsurekci, Cihangül Bayhan, et al. "682. The Changing Epidemiology of Bacterial Meningitis During 2015–2017 in Turkey: A Hospital-Based Prospective Surveillance Study." Open Forum Infectious Diseases 5, suppl_1 (2018): S246. http://dx.doi.org/10.1093/ofid/ofy210.689.

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Abstract Background The etiology of bacterial meningitis in Turkey has been changed after the implementation of conjugated vaccines against Streptococcus pneumonia and Haemophilus influenzae type b (Hib) in Turkish national immunization schedule. Methods. This prospective study was conducted in 25 hospitals located seven regions of Turkey (representing 30% of Turkey population) and children aged between 1 month and 18 years with suspected meningitis and hospitalized were included. Cerebrospinal fluid samples were collected and bacterial identification was made according to the multiplex PCR as
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Caesar, Nicole M., Kenneth A. Myers, and Xin Fan. "Neisseria meningitidis serogroup B vaccine development." Microbial Pathogenesis 57 (April 2013): 33–40. http://dx.doi.org/10.1016/j.micpath.2013.02.003.

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SUN, X., H. ZHOU, L. XU, et al. "Prevalence and genetic diversity of two adhesion-related genes, pilE and nadA, in Neisseria meningitidis in China." Epidemiology and Infection 141, no. 10 (2013): 2163–72. http://dx.doi.org/10.1017/s0950268812002944.

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SUMMARYThe main Neisseria meningitidis adhesion molecules, type IV pili (Tfp) and Neisseria adhesion A (NadA), play important roles in the pathogenesis of invasive meningococcal disease. PilE is the major Tfp subunit. In this study, the prevalence and genetic diversity of pilE and nadA were investigated in the prevalent serogroups and clonal complexes (CC) of N. meningitidis isolated in China. All serogroup A strains belonging to CC1 and CC5 and all CC11 serogroup W135 strains were clustered into class II PilE clades. All serogroup C and most of serogroup B isolates except CC8 and ST5642 were
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Moran, Elizabeth E., Robert Burden, Joseph E. Labrie, et al. "Analysis of the Bactericidal Response to an Experimental Neisseria meningitidis Vesicle Vaccine." Clinical and Vaccine Immunology 19, no. 5 (2012): 659–65. http://dx.doi.org/10.1128/cvi.00070-12.

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ABSTRACTRabbit immunogenicity studies on an experimental trivalent native outer membrane vesicle vaccine derived from three serogroup B strains were conducted to evaluate the effectiveness of this vaccine at inducing an antibody response with serum bactericidal activity against meningococcal strains of other serogroups in addition to serogroup B strains. The results showed that the vaccine was capable of inducing an effective broad-based bactericidal antibody response in rabbits against a small sample ofNeisseria meningitidisstrains of serogroups C, W135, and X and, to a lesser extent, serogro
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Diaz Romero, J., and I. M. Outschoorn. "Current status of meningococcal group B vaccine candidates: capsular or noncapsular?" Clinical Microbiology Reviews 7, no. 4 (1994): 559–75. http://dx.doi.org/10.1128/cmr.7.4.559.

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Meningococcal meningitis is a severe, life-threatening infection for which no adequate vaccine exists. Current vaccines, based on the group-specific capsular polysaccharides, provide short-term protection in adults against serogroups A and C but are ineffective in infants and do not induce protection against group B strains, the predominant cause of infection in western countries, because the purified serogroup B polysaccharide fails to elicit human bactericidal antibodies. Because of the poor immunogenicity of group B capsular polysaccharide, different noncapsular antigens have been considere
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Ispasanie, Emma, Gerd Pluschke, Abraham Hodgson, Ali Sie, Calman MacLennan, and Oliver Koeberling. "Characterization of vaccine antigens of meningococcal serogroup W isolates from Ghana and Burkina Faso from 2003 to 2009." F1000Research 3 (November 3, 2014): 264. http://dx.doi.org/10.12688/f1000research.3881.1.

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Neisseria meningitidis is a major cause of bacterial meningitis and a considerable health problem in the 25 countries of the ‘African Meningitis Belt’ that extends from Senegal in West Africa to Ethiopia in the East. Approximately 80% of cases of meningococcal meningitis in Africa have been caused by strains belonging to capsular serogroup A. After the introduction of a serogroup A conjugate polysaccharide vaccine, MenAfriVac™, that began in December 2010, the incidence of meningitis due to serogroup A has markedly declined in this region. Currently, serogroup W of N. meningitidis accounts for
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Kolb-Mäurer, Annette, Alexandra Unkmeir, Ulrike Kämmerer, et al. "Interaction of Neisseria meningitidis with Human Dendritic Cells." Infection and Immunity 69, no. 11 (2001): 6912–22. http://dx.doi.org/10.1128/iai.69.11.6912-6922.2001.

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ABSTRACT Infection with Neisseria meningitidis serogroup B is responsible for fatal septicemia and meningococcal meningitis. The severity of disease directly correlates with the production of the proinflammatory cytokines tumor necrosis factor alpha (TNF-α), interleukin-1 (IL-1), IL-6, and IL-8. However, the source of these cytokines has not been clearly defined yet. Since bacterial infection involves the activation of dendritic cells (DCs), we analyzed the interaction of N. meningitidis with monocyte-derived DCs. Using N. meningitidis serogroup B wild-type and unencapsulated bacteria, we foun
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TROTTER, C. L., N. J. GAY, and W. J. EDMUNDS. "The natural history of meningococcal carriage and disease." Epidemiology and Infection 134, no. 3 (2005): 556–66. http://dx.doi.org/10.1017/s0950268805005339.

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The prevalence of Neisseria meningitidis carriage is highest in teenagers and lowest in young children. In contrast, invasive meningococcal disease is most common in young children with a smaller secondary peak in teenagers. Data on carriage and disease were analysed to quantify the risks of infection and disease by age and serogroup. The forces of infection for serogroups B, C, other meningococci and Neisseria lactamica were modelled together with the risk of disease given infection for serogroups B and C, using maximum likelihood to fit the models to the available data. The risk of meningoco
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Swartley, John S., Li-Jun Liu, Yoon K. Miller, Larry E. Martin, Srilatha Edupuganti та David S. Stephens. "Characterization of the Gene Cassette Required for Biosynthesis of the (α1→6)-LinkedN-Acetyl-d-Mannosamine-1-Phosphate Capsule of Serogroup A Neisseria meningitidis". Journal of Bacteriology 180, № 6 (1998): 1533–39. http://dx.doi.org/10.1128/jb.180.6.1533-1539.1998.

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ABSTRACT The (α1→6)-linkedN-acetyl-d-mannosamine-1-phosphate meningococcal capsule of serogroup A Neisseria meningitidisis biochemically distinct from the sialic acid-containing capsules produced by other disease-associated meningococcal serogroups (e.g., B, C, Y, and W-135). We defined the genetic cassette responsible for expression of the serogroup A capsule. The cassette comprised a 4,701-bp nucleotide sequence located between the outer membrane capsule transporter gene, ctrA, and galE, encoding the UDP-glucose-4-epimerase. Four open reading frames (ORFs) not found in the genomes of the oth
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Sacchi, Claudio Tavares, Ana Paula Silva de Lemos, Maria Cecília Outeiro Gorla, and Carl E. Frasch. "Monoclonal antibody to serotype 17 of Neisseria meningitidis and their prevalence in Brazilian States." Revista do Instituto de Medicina Tropical de São Paulo 37, no. 1 (1995): 1–5. http://dx.doi.org/10.1590/s0036-46651995000100001.

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Neisseria meningitidis are gram-negative diplococci responsible for cases of meningococcal disease all over the world. The epidemic potential of N. meningitidis serogroup B and C is clearly a function of their serotype antigens more than of their capsular polysaccharides. Until recently, hiperimmune sera were used to detect typing antigens on the bacteria. The advent of monoclonal antibodies (MAbs) offered the opportunity to eliminate many of the cross-reactions and have improved the accuracy and reproducibility of meningococcal serotyping. We have produced a MAb to the outer membrane protein
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Mado, SM, U. Abubakar, SO Onazi, and GO Adeoye. "Epidemic cerebrospinal meningitis in children at Federal Medical Centre, Gusau, Zamfara state, Nigeria." Nigerian Journal of Paediatrics 40, no. 2 (2013): 169–71. http://dx.doi.org/10.4314/njp.v40i2.12.

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Epidemic meningococcal meningitis is a major public health problem still affecting tropical countries, particularly in Sub-Saharan Africa, which lieswithin African meningitis belt. Repeated large scale epidemics of CSM have been reported in northern Nigeria for the past four decades. It is one of the important causes of morbidity and mortality in these regions. Mortality from the CSM remains high despite advances in treatment modalities. Neisseria meningitidis serogroup A have been the major cause of large scale epidemics in tropical countries, while serogroups B, C, Y and W-135 are responsibl
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Soler-Garcia, Aleix, Mariona Fernández de Sevilla, Raquel Abad, et al. "Meningococcal Serogroup B Disease in Vaccinated Children." Journal of the Pediatric Infectious Diseases Society 9, no. 4 (2019): 454–59. http://dx.doi.org/10.1093/jpids/piz071.

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Abstract Background Neisseria meningitidis serogroup B (MenB) is the most frequent cause of invasive meningococcal disease (IMD) in Spain. The multicomponent vaccine against MenB (4CMenB) was approved in Spain in January 2014. Methods We present 4 cases of children who developed MenB-associated IMD despite previous vaccination with 4CMenB. Extensive immunologic diagnostic work-up was performed in order to rule out any immunodeficiency. Also, molecular characterization of the MenB strain was conducted to determine whether bacterial antigens matched vaccine antigens. Results Among the 4 patients
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de Filippis, Ivano. "Quest for a broad-range vaccine against Neisseria meningitidis serogroup B: implications of genetic variations of the surface-exposed proteins." Journal of Medical Microbiology 58, no. 9 (2009): 1127–32. http://dx.doi.org/10.1099/jmm.0.011189-0.

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Despite the development of new vaccine formulations using new biotechnology resources to combat emerging and re-emerging diseases, serogroup B meningococcal disease is still a worldwide burden, accounting for many deaths and disabilities every year. The successful approach of coupling a polysaccharide (PS) with a carrier protein in order to increase long-lasting immunity could not be exploited against Neisseria meningitidis B because of the limitations of using the capsular PS of serogroup B meningococci. Tailor-made vaccines based on exposed proteins were shown to be a promising approach to o
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Coppens, Isabelle, Sylvie Alonso, Rudy Antoine, et al. "Production of Neisseria meningitidisTransferrin-Binding Protein B by RecombinantBordetella pertussis." Infection and Immunity 69, no. 9 (2001): 5440–46. http://dx.doi.org/10.1128/iai.69.9.5440-5446.2001.

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ABSTRACT Neisseria meningitidis serogroup B infections are among the major causes of fulminant septicemia and meningitis, especially severe in young children, and no broad vaccine is available yet. Because of poor immunogenicity of the serogroup B capsule, many efforts are now devoted to the identification of protective protein antigens. Among those are PorA and, more recently, transferrin-binding protein B (TbpB). In this study, TbpB of N. meningitidiswas genetically fused to the N-terminal domain of the Bordetella pertussis filamentous hemagglutinin (FHA), and thefha-tbpB hybrid gene was exp
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Honskus, Michal, Zuzana Okonji, Martin Musilek, and Pavla Krizova. "Whole genome sequencing of Neisseria meningitidis Y isolates collected in the Czech Republic in 1993-2018." PLOS ONE 17, no. 3 (2022): e0265066. http://dx.doi.org/10.1371/journal.pone.0265066.

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Introduction The study presents the analysis of whole genome sequencing (WGS) data for Neisseria meningitidis serogroup Y isolates collected in the Czech Republic and their comparison to other countries. The aim of the study was to determine whether there are lineages of N. meningitidis serogroup Y in the Czech Republic genetically related to foreign ones that have been causing an increase of the morbidity and the mortality of invasive meningococcal disease (IMD) world-wide recently. Material and methods The WGS data of 43 Czech N. meningitidis Y isolates, 35 from IMD and 8 from healthy carrie
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Unkmeir, Alexandra, Ulrike Kämmerer, Anne Stade, et al. "Lipooligosaccharide and Polysaccharide Capsule: Virulence Factors of Neisseria meningitidis That Determine Meningococcal Interaction with Human Dendritic Cells." Infection and Immunity 70, no. 5 (2002): 2454–62. http://dx.doi.org/10.1128/iai.70.5.2454-2462.2002.

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ABSTRACT In this work we analyzed the roles of meningococcal lipooligosaccharide (LOS) and capsule expression in the interaction of Neisseria meningitidis with human dendritic cells (DC). Infection of DC with serogroup B wild-type meningococci induced a strong burst of the proinflammatory cytokines and chemokines tumor necrosis factor alpha, interleukin-6 (IL-6), and IL-8. In contrast, a serogroup B mutant strain lacking LOS expression barely led to cytokine induction, demonstrating that meningococcal LOS is the main mediator of the proinflammatory response in human DC. Sialylation of meningoc
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KYAW, M. H., J. C. BRAMLEY, S. CLARKE, P. CHRISTIE, I. G. JONES, and H. CAMPBELL. "Prevalence of moderate penicillin resistant invasive Neisseria meningitidis infection in Scotland, 1994–9." Epidemiology and Infection 128, no. 2 (2001): 149–56. http://dx.doi.org/10.1017/s0950268801006549.

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We examined the serological characteristics of 774 invasive meningococcal isolates collected through an active laboratory-based surveillance system in Scotland from 1994 to 1999. Of these, 72–73% of isolates were tested for susceptibility to several antimicrobial agents. Meningococci with high-level resistance to sulphadiazine had a prevalence of 10% and incidence of 0·22 per 100000 population. High-level resistance to penicillin and other antibiotics was not detected. The prevalence of moderate penicillin resistant meningococci was 8·3%. There was no increase in moderate penicillin resistant
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Sharp, Susan E., and Robert J. Poppiti. "Neisseria meningitidis serogroup B meningitis with a negative direct antigen test." Clinical Microbiology Newsletter 12, no. 23 (1990): 183. http://dx.doi.org/10.1016/0196-4399(90)90040-i.

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Tondella, Maria Lucia C., Mike W. Reeves, Tanja Popovic, Nancy Rosenstein, Brian P. Holloway, and Leonard W. Mayer. "Cleavase Fragment Length Polymorphism Analysis of Neisseria meningitidis Basic Metabolic Genes." Journal of Clinical Microbiology 37, no. 8 (1999): 2402–7. http://dx.doi.org/10.1128/jcm.37.8.2402-2407.1999.

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Cleavase fragment length polymorphism (CFLP) is a subtyping system based on the property of the enzyme cleavase to recognize junctions between single- and double-stranded regions of DNA formed after denaturation and cooling. To assess the capacity of CFLP for discriminating Neisseria meningitidis serogroup B strains belonging to the electrophoretic type (ET) 5 (ET-5) complex from other serogroup B strains, 30 serogroup B N. meningitidisisolates were subtyped by CFLP with internal fragments of five housekeeping genes, adk, aspC,carA, dhp, and glnA. Two genes (glnA and carA) which demonstrated a
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Moe, G. R., P. Zuno-Mitchell, S. S. Lee, A. H. Lucas, and D. M. Granoff. "Functional Activity of Anti-Neisserial Surface Protein A Monoclonal Antibodies against Strains of Neisseria meningitidis Serogroup B." Infection and Immunity 69, no. 6 (2001): 3762–71. http://dx.doi.org/10.1128/iai.69.6.3762-3771.2001.

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ABSTRACT Neisserial surface protein A (NspA) is currently being investigated with humans as a candidate vaccine for the prevention of meningococcal disease. Although NspA is highly conserved, the ability of anti-NspA antibodies to bind to or elicit complement-mediated bactericidal activity against diverse Neisseria meningitidis serogroup B strains is controversial. To evaluate strain differences in NspA surface accessibility and susceptibility to bactericidal activity, we prepared murine immunoglobulin G2a anti-NspA monoclonal antibodies (MAbs) and evaluated their functional activity against 1
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Kostyukova, N. N., and V. A. Bekhalo. "Current Meningococcal Vaccines: Advantages and Disadvantages and New Challenges." Epidemiology and Vaccine Prevention 15, no. 4 (2016): 64–73. http://dx.doi.org/10.31631/2073-3046-2016-15-4-64-73.

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The article reviews and analyses the vaccines against invasive meningococcal disease, widely used in practice since 70s-80s of the last century, as well as newly developed ones, the efficacy of which is not completely clear yet. The advantages and disadvantages of polysaccharide and glycoprotein vaccines against meningococci of serogroups A, C, Y, W135 and of protein «vesicle» and geneticengineering vaccines based on «reverse vaccinology» against serogroup B are discussed. Some options for composition of future vaccines under development are presented. Briefly the meningococcal vaccines used i
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LEMOS, Ana Paula S., Claudio T. SACCHI, Maria V. PAIVA, Teresa I. YARA, Carmo Elias A. MELLES, and Leonard W. MAYER. "Genetic relationships among serogroup B: serotype 4 Neisseria meningitidis strains." Revista do Instituto de Medicina Tropical de São Paulo 43, no. 3 (2001): 119–24. http://dx.doi.org/10.1590/s0036-46652001000300001.

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We compared the results obtained by serotyping of PorB epitopes using an expanded panel of monoclonal antibodies (mAb) including mAb 7 and mAb 10, with results obtained by RFLP of rRNA genes (ribotyping). The purpose of this study was to assess the correlation between phenotypic- and genotypic- methods for typing N. meningitidis. The ribotypes obtained using ClaI or EcoRV endonucleases grouped the strains in seven and two different patterns, respectively. This additional characterization of PorB epitopes improved the correlation between these two methods of typing N. meningitidis.
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Bettinger, Julie, Manish Sadarangani, Nicole Le Saux, et al. "57 Update of IMPACT Invasive Meningococcal Surveillance, 2016-2020." Paediatrics & Child Health 27, Supplement_3 (2022): e27-e28. http://dx.doi.org/10.1093/pch/pxac100.056.

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Abstract Background Meningococcal conjugate vaccine (MCV) programs in Canada began in 2002. Objectives This study examines the most recent surveillance data to describe the current Canadian epidemiology of invasive meningococcal disease (IMD) and the effect of MCV programs, especially on age and serogroup distribution. Design/Methods Active metropolitan area surveillance for hospitalization of adults and children due to IMD, which was defined as a clinical infection with Neisseria meningitidis isolated or detected by molecular methods or culture from a sterile body site. The study was conducte
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Johswich, Kay O., Jianwei Zhou, Dennis K. S. Law, et al. "Invasive Potential of Nonencapsulated Disease Isolates of Neisseria meningitidis." Infection and Immunity 80, no. 7 (2012): 2346–53. http://dx.doi.org/10.1128/iai.00293-12.

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ABSTRACTThe capsule ofNeisseria meningitidisis the major virulence factor that enables this bacterium to overcome host immunity elicited by complement and phagocytes, rendering it capable of surviving in blood. As such, nonencapsulatedN. meningitidisisolates are generally considered nonpathogenic. Here, we consider the inherent virulence of two nonencapsulatedN. meningitidisisolates obtained from our national surveillance of infected blood cultures in Canada. Capsule deficiency of both strains was confirmed by serology and PCR for thectrAtoctrDgenes andsiaAtosiaCgenes, as well assiaDgenes spec
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Haghi, Fakhri, Shahin Najar Peerayeh, Seyed Davar Siadat, and Mehran Montajabiniat. "Cloning, expression and purification of outer membrane protein PorA of Neisseria meningitidis serogroup B." Journal of Infection in Developing Countries 5, no. 12 (2011): 856–62. http://dx.doi.org/10.3855/jidc.1557.

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Introduction: Neisseria meningitidis is a major causative agent of bacterial septicemia and meningitis in humans. Currently, there are no vaccines to prevent disease caused by strains of N. meningitidis serogroup B. PorA is a major component of the outer membrane of N. meningitidis and functions as a cationic porin. This study aimed to clone and determine the expression of PorA. Methodology: A 1200 bp fragment of porA gene was amplified by PCR from serogroup B N. meningitidis and then cloned into prokaryotic expression vector pET-32a. For expression of recombinant protein, pET32a-porA plasmid
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de Filippis, Ivano, Ana Paula S. de Lemos, Jessica B. Hostetler, et al. "Molecular Epidemiology of Neisseria meningitidis Serogroup B in Brazil." PLoS ONE 7, no. 3 (2012): e33016. http://dx.doi.org/10.1371/journal.pone.0033016.

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Böhm, Raphael, Friedrich Freiberger, Katharina Stummeyer, Rita Gerardy-Schahn, Mark von Itzstein, and Thomas Haselhorst. "Neisseria meningitidis Serogroup B Polysialyltransferase: Insights into Substrate Binding." ChemBioChem 11, no. 2 (2010): 170–74. http://dx.doi.org/10.1002/cbic.200900659.

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Balmer, Paul, and Laura J. York. "Optimal use of meningococcal serogroup B vaccines: moving beyond outbreak control." Therapeutic Advances in Vaccines and Immunotherapy 6, no. 3 (2018): 49–60. http://dx.doi.org/10.1177/2515135518781757.

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Neisseria meningitidis is a major cause of meningitis and septicemia globally. Vaccines directed against N. meningitidis serogroup B (MenB) have been used to control sporadic and sustained disease in industrialized and non-industrialized countries. Early outer membrane vesicle (OMV) vaccines effectively reduced MenB disease in countries such as Norway, New Zealand, and France; however, these vaccines were highly specific for their targeted outbreak strain, did not elicit a durable immune response, and were ineffective for widespread use due to the diversity of MenB-disease-causing isolates. Re
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Langereis, Jeroen D., Bryan van den Broek, Sjoerd Franssen, et al. "Eculizumab impairs Neisseria meningitidis serogroup B killing in whole blood despite 4CMenB vaccination of PNH patients." Blood Advances 4, no. 15 (2020): 3615–20. http://dx.doi.org/10.1182/bloodadvances.2020002497.

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Abstract Complement C5 inhibitor eculizumab has a great impact on the treatment of patients with paroxysmal nocturnal hemoglobinuria (PNH). However, this treatment success has a major drawback: a substantially increased susceptibility for life-threatening Neisseria meningitidis infections. Therefore, N meningitidis vaccination is strongly advised before initiating complement C5–blocking therapy. In this study, we show that the multicomponent N meningitidis serogroup B (4CMenB) vaccination of PNH patients treated with eculizumab results in a significant increase in anti–N meningitidis serogroup
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Semchenko, Evgeny A., Aimee Tan, Ray Borrow, and Kate L. Seib. "The Serogroup B Meningococcal Vaccine Bexsero Elicits Antibodies to Neisseria gonorrhoeae." Clinical Infectious Diseases 69, no. 7 (2018): 1101–11. http://dx.doi.org/10.1093/cid/ciy1061.

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Abstract Background Neisseria gonorrhoeae and Neisseria meningitidis are closely-related bacteria that cause a significant global burden of disease. Control of gonorrhoea is becoming increasingly difficult, due to widespread antibiotic resistance. While vaccines are routinely used for N. meningitidis, no vaccine is available for N. gonorrhoeae. Recently, the outer membrane vesicle (OMV) meningococcal B vaccine, MeNZB, was reported to be associated with reduced rates of gonorrhoea following a mass vaccination campaign in New Zealand. To probe the basis for this protection, we assessed the cross
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Sorhouet Pereira, Cecilia, Mabel Regueira, and Marta Mollerach. "PorA types in Neisseria meningitidis serogroup B isolated in Argentina from 2001 to 2003: implications for the design of an outer membrane protein-based vaccine." Journal of Medical Microbiology 57, no. 3 (2008): 338–42. http://dx.doi.org/10.1099/jmm.0.47631-0.

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Identification of Neisseria meningitidis PorA types remains important, as the PorA protein is a major immunogenic component of several meningococcal vaccines under development. In this study, 191 N. meningitidis serogroup B isolates collected in Argentina through active laboratory-based surveillance from 2001 to 2003 were serosubtyped. Nucleotide sequences of the porA variable region 1 (VR1) and VR2 regions were determined in 52 non-serosubtypeable isolates. A substantial number of distinct VR types were identified, and a new VR2 variant from the P1.16 family was described. This is the first r
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Seyed, Davar Siadat, Reza Naddaf Saied, Zangeneh Mehrangiz, et al. "Outer membrane vesicle of Neisseria meningitidis serogroup B as an adjuvant in immunization of rabbit against Neisseria meningitidis serogroup A." African Journal of Microbiology Research 5, no. 19 (2011): 3090–95. http://dx.doi.org/10.5897/ajmr11.361.

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., S. D. Siadat, D. Norouzian ., B. Tabaraie ., et al. "Comparative Studies of Conjugated Capsular Polysaccharide of Neisseria meningitidis Serogroup A with Outer Membrane Vesicle of Neisseria meningitidis Serogroup B." Research Journal of Microbiology 2, no. 4 (2007): 337–45. http://dx.doi.org/10.3923/jm.2007.337.345.

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Pizza, Mariagrazia, Rafik Bekkat-Berkani, and Rino Rappuoli. "Vaccines against Meningococcal Diseases." Microorganisms 8, no. 10 (2020): 1521. http://dx.doi.org/10.3390/microorganisms8101521.

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Neisseria meningitidis is the main cause of meningitis and sepsis, potentially life-threatening conditions. Thanks to advancements in vaccine development, vaccines are now available for five out of six meningococcal disease-causing serogroups (A, B, C, W, and Y). Vaccination programs with monovalent meningococcal serogroup C (MenC) conjugate vaccines in Europe have successfully decreased MenC disease and carriage. The use of a monovalent MenA conjugate vaccine in the African meningitis belt has led to a near elimination of MenA disease. Due to the emergence of non-vaccine serogroups, recommend
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43

Kostyukova, N. N., and V. A. Bekhalo. "Meningococcal Vaccines of New Generations – the First 20 Years of Use." Epidemiology and Vaccinal Prevention 20, no. 4 (2021): 103–13. http://dx.doi.org/10.31631/2073-3046-2021-20-4-103-113.

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Relevance. Meningococcal vaccine refers to any of the vaccines used to prevent infection by Neisseria meningitidis. Therefore, there is a great scientific and practical interest in the existing and developed menicococcal vaccines.Aims the review is to provide an analysis: literature data on the effectiveness of meningococcal vaccines of new generations - conjugated polysaccharide serogroups A, C, W and Y and protein serogroup B.Conclusions. With regard to conjugated vaccines, there are a large number of reliable observations confirming the high immunological and epidemiological effectiveness o
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Mironov, Konstantin O., E. A. Yarygina, Aida Chagaryan, and Nataly Ivanchik. "The genetic characteristics of Neisseria meningitidis causing invasive meningococcal infections in Smolensk region." Clinical Microbiology and Antimicrobial Chemotherapy 22, no. 2 (2020): 92–95. http://dx.doi.org/10.36488/cmac.2020.2.92-95.

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Objective. To determine antigenic and genetic characteristics of Neisseria meningitidis isolated from the patients with invasive meningococcal infections in Smolensk region in comparison with those circulating in other regions. Materials and Methods. A total of 14 cerebrospinal fluid samples obtained in 2016–2019 and containing N. meningitidis DNA were tested using AmpliSens® Nm-ABCW kit, multilocus sequence typing and antigenic finetyping of outer membrane proteins. The results were analyzed by the BURST algorithm and other functionalities available at PubMLST.org (Jolley K. et al. 2018). Res
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O'Dwyer, Clíona A., Karen Reddin, Denis Martin, et al. "Expression of Heterologous Antigens in Commensal Neisseria spp.: Preservation of Conformational Epitopes with Vaccine Potential." Infection and Immunity 72, no. 11 (2004): 6511–18. http://dx.doi.org/10.1128/iai.72.11.6511-6518.2004.

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ABSTRACT Commensal neisseriae share with Neisseria meningitidis (meningococcus) a tendency towards overproduction of the bacterial outer envelope, leading to the formation and release during growth of outer membrane vesicles (OMVs). OMVs from both meningococci and commensal neisseriae have shown promise as vaccines to protect against meningococcal disease. We report here the successful expression at high levels of heterologous proteins in commensal neisseriae and the display, in its native conformation, of one meningococcal outer membrane protein vaccine candidate, NspA, in OMVs prepared from
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46

Rameix-Welti, Marie-Anne, Maria Leticia Zarantonelli, Dario Giorgini, et al. "Influenza A Virus Neuraminidase Enhances Meningococcal Adhesion to Epithelial Cells through Interaction with Sialic Acid-Containing Meningococcal Capsules." Infection and Immunity 77, no. 9 (2009): 3588–95. http://dx.doi.org/10.1128/iai.00155-09.

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ABSTRACT The underlying mechanisms of the epidemiological association between influenza virus infections and Neisseria meningitidis invasive infections are not fully understood. Here we report that adhesion of N. meningitidis to human Hec-1-B epithelial cells is enhanced by influenza A virus (IAV) infection. A potential role of the viral neuraminidase (NA) in facilitating meningococcal adhesion to influenza virus-infected epithelial cells was examined. Expression of a recombinant IAV NA in Hec-1-B human epithelial cells increased the adhesion of strains of N. meningitidis belonging to the sial
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47

HSUEH, P. R., L. J. TENG, T. Y. LIN, et al. "Re-emergence of meningococcal disease in Taiwan: circulation of domestic clones of Neisseria meningitidis in the 2001 outbreak." Epidemiology and Infection 132, no. 4 (2004): 637–45. http://dx.doi.org/10.1017/s0950268804002316.

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The annual incidence of meningococcal disease (meningitis and septicaemia) in Taiwan was 0·94/105 population in 1953. It then declined to below 0·001 from 1980 to 1987, and re-emerged in 2000 with a rate of 0·07/105 population. In 2001 there was a further increase in incidence (43 cases, 0·19/105). Of 43 isolates of Neisseria meningitidis available for this study, including 41 from patients treated in 2001, three (7·0%) were penicillin insensitive (MIC [ges ]0·12 μg/ml), though all were β-lactamase negative; 16 (37·2%) were resistant to trimethoprim–sulphamethoxazole sulphamethoxazole (MIC [ge
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Richardson, Anthony R., and Igor Stojiljkovic. "HmbR, a Hemoglobin-Binding Outer Membrane Protein of Neisseria meningitidis, Undergoes Phase Variation." Journal of Bacteriology 181, no. 7 (1999): 2067–74. http://dx.doi.org/10.1128/jb.181.7.2067-2074.1999.

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ABSTRACT Neisseria meningitidis uses hemoglobin (Hb) as an iron source via two TonB-dependent outer membrane receptors, HmbR and HpuB. Analysis of 25 epidemiologically unrelated clinical isolates from serogroups A, B, C, and Y revealed that 64% strains possessed both Hb receptor genes. Examination of the hmbR expression pattern in strains in which the hpuB gene was genetically inactivated revealed two distinct Hb utilization phenotypes. Five strains retained the ability to grow as a confluent lawn, while seven grew only as single colonies around Hb discs. The single-colony phenotype observed f
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49

Tsang, Raymond S. W., and Wendell D. Zollinger. "Serological Specificities of Murine Hybridoma Monoclonal Antibodies against Neisseria meningitidis Serogroups B, C, Y, and W135 and Evaluation of Their Usefulness as Serogrouping Reagents by Indirect Whole-Cell Enzyme-Linked Immunosorbent Assay." Clinical Diagnostic Laboratory Immunology 12, no. 1 (2005): 152–56. http://dx.doi.org/10.1128/cdli.12.1.152-156.2005.

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ABSTRACT Murine hybridoma monoclonal antibodies (MAbs) were produced against the capsular antigens of serogroups B, C, Y, and W135 meningococci. Each serogroup-specific MAb reacted with the extracted capsular polysaccharide from its homologous serogroup only and did not react with capsules from the other three serogroups. The application of these MAbs for serogroup identification of meningococci was demonstrated by their abilities to correctly identify 183 clinical isolates of 185 meningococci recovered from individual invasive meningococcal disease (IMD) patients during routine surveillance i
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Tyler, Shaun, and Raymond Tsang. "Genetic analysis of Canadian isolates of C:2a:P1.2,5 and B:2a:P1.2,5Neisseria meningitidisstrains belonging to the hypervirulent clone of ET-15." Canadian Journal of Microbiology 50, no. 6 (2004): 433–43. http://dx.doi.org/10.1139/w04-024.

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Isolates of the hypervirulent Neisseria meningitidis clone ET-15 found to express the serogroup B antigen were investigated and compared with representative members of serogroup B and C isolates. Clonal-clustering methods clearly grouped the B:ET15 isolates with C:ET15 isolates, indicating the only major difference between the two groups was in the capsule expressed. The organization of the cps operon from the B:ET15 isolates was found to be consistent with typical serogroup B isolates and differed from serogroup C isolates only in the sialyl transferase gene present. This suggests that these
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