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Tesis sobre el tema "Neovascularisation"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 25 de julio de 2025

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1

Faraj, Lana Akram. "Corneal neovascularisation : evaluation, pathology and treatment." Thesis, University of Nottingham, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.718466.

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The cornea is the clear window of the eye and its main refractive media. Corneal avascularity is essential to maintain this function, and this is evolutionarily highly conserved. Corneal vascularisation can result from different types of insults, causing reduced vision and posing a threat to the survival of corneal grafts. We prospectively reviewed 165 patients with corneal vascularisation establishing a reproducible classification of corneal vessels. We classified corneal vessels in to young active, old active, mature, partially regressed and regressed vessels. Patterns of vascularisations di

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2

Balaggan, K. S. "Development of gene therapy for choroidal neovascularisation." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1335615/.

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Exudative age-related macular degeneration, characterised by choroidal neovascularisation (CNV), is the leading cause of severe visual impairment in developed societies. Until recently, established treatments were of limited efficacy, and associated with other disadvantages including being inherently destructive therapies. Although novel anti-VEGF pharmacotherapy has since revolutionised the management and prognosis of many patients, current treatment regimens have distinct limitations, particularly in terms of the probable requirement for life-long, frequent invasive dosing, and associated cu

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3

Tarroux, Francis. "Tentative d'induction d'un modele experimental animal de neo-vascularisation retinienne." Toulouse 3, 1988. http://www.theses.fr/1988TOU31317.

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4

CHAN, Kim Hoe. "Molecular and Cellular Determinants of Neovascularisation and Vascular Repair." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/9889.

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Cardiovascular disease remains the leading cause of death worldwide. However, there remain a significant number of patients who are not eligible for current treatment options. Therapeutic angiogenesis offer great potential in the treatment of cardiovascular disease. Recent experiments demonstrated that haem oxygenase-1 (Hmox1) possesses pro-angiogenic and atheroprotective properties. Recent studies have also shown that the vascular protective effects of Hmox1 may be mediated by endothelial progenitor cell (EPC) mobilisation. EPCs are implicated in vascular regeneration and angiogenesis. Howeve

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5

GINESTE, CABARE MARIE-THERESE. "Les neovascularisations primitives et secondaires de la papille : a propos d'un cas." Toulouse 3, 1988. http://www.theses.fr/1988TOU31325.

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6

BRUNON, GUYONNET MICHELE. "Exophtalmies par neoformation vasculaire orbitaire." Saint-Etienne, 1989. http://www.theses.fr/1989STET6020.

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7

CALENDINI, ERIC. "Traitement du glaucome neovasculaire chez le diabetique." Nice, 1990. http://www.theses.fr/1990NICE6005.

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8

TAVERNIER, LEMAN ANNICK. "Les membranes neovasculaires choroidiennes chez l'enfant." Lille 2, 1990. http://www.theses.fr/1990LIL2M036.

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9

Stone, Oliver Andrew. "On the origin of blood vessels : mechanisms of post-natal neovascularisation." Thesis, University of Bristol, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.520634.

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10

SALAMON, MAROUN. "Modeles experimentaux de decollement de retine tractionnel et de neovascularisation preretinienne." Nice, 1992. http://www.theses.fr/1992NICE6595.

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11

Dew, Lindsey. "Development of angiogenic models to investigate neovascularisation for tissue engineering applications." Thesis, University of Sheffield, 2016. http://etheses.whiterose.ac.uk/12174/.

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The aim of this project was to develop in vitro models for angiogenesis that have the capability of combining pro-angiogenic cells with an extracellular matrix (ECM) component that can be monitored under flow conditions to learn more about the ‘rules’ of angiogenesis. Significant advancement has been made in the field of tissue engineering in recent years, however one of the current obstacles limiting progression is the production of thick, complex tissues due to the lack of rapid neovascularisation of the constructs upon implantation. Blood vessel formation is tightly regulated and relies on

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12

May, Leigh A. "The production and characterisation of transgenic disease models for retinal ocular neovascularisation." University of Western Australia. Centre for Ophthalmology and Visual Science, 2004. http://theses.library.uwa.edu.au/adt-WU2006.0047.

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[Truncated abstract] One of the barriers to understanding and preventing proliferative diabetic retinopathy in humans has been the lack of an appropriate animal model. Historically dog, rat and mouse models of diabetic retinopathy have been studied but none of these exhibit the later changes of proliferative diabetic retinopathy. Animals can be rendered diabetic by surgical pancreatectomy or the use of chemicals such as allozan or streptozotocin or by feeding of a high galactose diet. Alternatively, spontaneous rodent models of diabetes have been examined such as the BB rat, KK mouse or NOD mo

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13

Robbie, S. J. "The role of innate immune cells in ocular ageing and pathological neovascularisation." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1348581/.

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Age-related macular degeneration (AMD) is the major cause of vision loss in the developed world. AMD is a chronic progressive disorder of the outer retina leading to vision loss from atrophy (geographic atrophy) and/or the development of choroidal neovascularisation (CNV). Mounting evidence indicates the importance of innate immunity in its pathogenesis. This thesis describes a programme of work conducted with the aim of further understanding the role of innate immune cells in AMD. Analysis of mouse cell suspensions by flow cytometry demonstrated significantly greater densities of innate immun

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14

Shah, Benoy Nalin. "The determinants of intra-plaque neovascularisation : a study by contrast-enhanced carotid ultrasonography." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/52796.

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Atherosclerosis is a chronic inflammatory disorder, initiated by arterial wall injury, mediated by well-recognised cardiovascular risk factors and culminating in formation of plaques, the patho-biological substrate that precedes events such as stroke and myocardial infarction. Intraplaque neovascularisation (IPN) is one of several defence mechanisms in response to atherosclerosis. With development of an atherosclerotic plaque within the intima, the distance between the deeper intimal layers and the luminal surface increases, producing hypoxia within the arterial wall. This stimulates release o

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15

TOLEDANO, ELIE. "Neovascularisation d'un lambeau cutane expanse a pedicule monovasculaire : etude experimentale preliminaire sur le porc." Clermont-Ferrand 1, 1993. http://www.theses.fr/1993CLF1MS26.

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16

Hatji, Elissavet. "Mecanismes d'action d'un facteur angiogenique : l'angiogenine ; etudes de ses interactions avec les cellules vasculaires, mise en evidence de ses recepteurs, expression et localisation tissulaire." Paris 11, 1996. http://www.theses.fr/1996PA11T019.

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17

BORHAN, MODJABI MARYAM. "Apport de l'angiographie au vert d'indocyanine dans l'identification et la localisation des neovaisseaux sous retiniens de la degenerescence maculaire liee a l'age." Amiens, 1994. http://www.theses.fr/1994AMIEM086.

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18

RIFFLART, DERUYTER GHISLAINE. "Comparaison des champs visuels centraux avant et apres photocoagulation au laser krypton des membranes neo-vasculaires dans la degenerescence maculaire liee a l'age." Amiens, 1990. http://www.theses.fr/1990AMIEM031.

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19

Confolent, Anne Sophie. "Cyclo-photocoagulation transclérale au laser Nd : Yag en mode thermique dans les glaucomes néo-vasculaires : étude réalisée à partir de 20 cas." Montpellier 1, 1992. http://www.theses.fr/1992MON11007.

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20

Gisslén, Karl. "The patellar tendon in junior elite volleyball players and an Olympic elite weightlifter." Doctoral thesis, Umeå universitet, Kirurgisk och perioperativ vetenskap, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-940.

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The principal aim of the present thesis was to prospectively follow (clinical status and ultrasound + Doppler findings) the patellar tendons in the young elite volleyball players at the Swedish National Centre for high school volleyball in Falköping. In an Olympic weightlifter with chronic painful jumper´s knee, the effects of treatment with sclerosing injections followed by early instituted very heavy weightlifting training, was also evaluated. First, in a prevalence study, we demonstrated that the clinical diagnosis patellar tendinopathy-jumper’s knee, together with structural tendon changes

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21

Chiffre, Thomas. "Efficacité de la radiothérapie dans la dégénérescence maculaire exsudative liée à l'âge." Bordeaux 2, 1999. http://www.theses.fr/1999BOR23042.

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22

Zhang, Huajun. "Functional characterisation of cardiac progenitors from patients with ischaemic heart disease." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:3b8a7199-c077-436c-bb89-cd354efe4414.

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Ischaemic heart disease (IHD) is the leading cause of death worldwide. Currently, even optimal medical therapies do not attenuate deterioration of the left ventricular (LV) function completely. Stem cell therapies, and recently cardiac stem cell therapies, have emerged as potential novel treatments for IHD. However, clinical evidence from randomised controlled studies has shown mixed results. Thus understanding what patient-related factors may affect the therapeutic performance of the cells may help improving treatment outcomes. The studies described in this thesis aim to understand how cardia

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23

Cherepanoff, Svetlana. "Age-related macular degeneration: histopathological and serum autoantibody studies." University of Sydney, 2008. http://hdl.handle.net/2123/2464.

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Doctor of Philosophy (PhD)<br>BACKGROUND: The accumulation of abnormal extracellular deposits beneath the retinal pigment epithelium characterises the pathology of early age-related macular degeneration. However, the histopathological threshold at which age-related changes become early AMD is not defined, and the effect of each of the deposits (basal laminar deposit and membranous debris) on disease progression is poorly understood. Evidence suggests that macrophages play a key role in the development of AMD lesions, but the influence of basal laminar deposit (BLamD) and membranous debris on t

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24

Bachelot, Thomas. "Thérapie génique par transfert rétroviral dans les cellules souches hématopoïétiques : développement des vecteurs et application au contrôle de la néoangiogenèse tumorale." Université Joseph Fourier (Grenoble), 2000. http://www.theses.fr/2000GRE10061.

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Malgre un investissement considerable, les resultats obtenus pour l'instant par la therapie genique sont encore tres modestes, principalement du fait de problemes de vectorisation. L'objectif de ce travail etait double : d'une part ameliorer les vecteurs utilises pour permettre le transfert de gene aux cellules souches hematopoietiques (csh) et, d'autre part, evaluer le potentiel antitumoral de la secretion systemique d'une molecule antiangiogenique naturelle a partir du systeme hematopoietique. Nous decrivons tout d'abord une technique originale de transduction retrovirale des cellules cd34+

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25

Alexander, Nadine. "Novel strategies for the cultivation of human choroidal vascular endothelial cells from cadaveric eye tissue." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/115014/1/115014_8878871_nadine_alexander_thesis.pdf.

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The aberrant growth of blood vessels in the posterior segment of the eye is a major symptom of age-related macular degeneration (AMD), the leading cause of irreversible blindness in the developed world. This project has enabled a significant step forward in the study of blood vessels that become diseased in patients suffering from AMD. In doing so, a previously uncharacterised cell type was identified, and with further refinement, could lead to potential novel strategies for wet-AMD therapies.

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26

Cherepanoff, Svetlana. "Age-related macular degeneration: histopathological and serum autoantibody studies." Thesis, The University of Sydney, 2007. http://hdl.handle.net/2123/2464.

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BACKGROUND: The accumulation of abnormal extracellular deposits beneath the retinal pigment epithelium characterises the pathology of early age-related macular degeneration. However, the histopathological threshold at which age-related changes become early AMD is not defined, and the effect of each of the deposits (basal laminar deposit and membranous debris) on disease progression is poorly understood. Evidence suggests that macrophages play a key role in the development of AMD lesions, but the influence of basal laminar deposit (BLamD) and membranous debris on the recruitment and programming

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27

Piechel, Lise. "Rôle du récepteur nucléaire Rev-erbα dans le contrôle de la fonction des cellules musculaires lisses au cours de l'athérosclérose". Electronic Thesis or Diss., Université de Lille (2022-....), 2024. http://www.theses.fr/2024ULILS078.

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Les maladies cardiovasculaires, principalement causées par l'athérosclérose, demeurent la première cause de mortalité dans le monde. L'athérosclérose est une maladie inflammatoire chronique de la paroi vasculaire provoquée par l'internalisation de lipides dans l'espace sous-endothéliale. Cette accumulation anormale déclenche l'infiltration de leucocytes et l'activation des cellules musculaires lisses (CML). Plus que l'obstruction des vaisseaux, l'instabilité et la rupture des plaques sont considérées comme les événements les plus délétères à l'origine d'infarctus du myocarde par exemple. Les d

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28

Pais, Mariana Beatriz Nunes Canelas. "Multimodel image : assessment of risk factors for the development of choroidal neovascularisation in the fellow eye." Master's thesis, 2012. http://hdl.handle.net/10316/29212.

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Trabalho final de mestrado integrado em Medicina (Oftalmologia), apresentado à Faculdade de Medicina da Universidade de Coimbra<br>Objectives To characterize the progression of eye fundus changes by multimodal imaging and to identify morphological and/or functional predictors of conversion in wet AMD in the fellow eyes of patients with exudative AMD. Sample Description and Methods Single-center, prospective, observational, longitudinal 2-year study. Sixty-two patients were enrolled in the study, with diagnosis of neovascular age-related macular degeneration in one eye and age-related maculo

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29

Perles-Barbacaru, Teodora-Adriana. "IMAGERIE PAR RESONANCE MAGNETIQUE DU VOLUME SANGUIN POUR LA CARACTERISATION DE LA NEOVASCULARISATION DANS LES TUMEURS CEREBRALES EXPERIMENTALES." Phd thesis, 2007. http://tel.archives-ouvertes.fr/tel-00564020.

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LA MESURE DU VOLUME SANGUIN CEREBRAL (VSC) PAR IMAGERIE PAR RESONANCE MAGNETIQUE (IRM) PERMET D'ETUDIER L'ANGIOGENESE TUMORALE. DANS CETTE THESE, UNE METHODE IRM, DITE METHODE T1 STATIONNAIRE RAPIDE (RSST1) POUR QUANTIFIER LE VSC EST PROPOSEE. LE PRINCIPE REPOSE SUR LES PROPRIETES DE LA RELAXATION LONGITUDINALE AVEC DES AGENTS DE CONTRASTE (AC) PARAMAGNETIQUES INTRAVASCULAIRES ET SUR UN MODELE DU CERVEAU BI-COMPARTIMENTAL EXTRA/INTRAVASCULAIRE SANS ECHANGE D'EAU. LA METHODE A ETE VALIDEE SUR DES RATS SAINS A 2.35T (VSC: 2 A 3%) ET LA SENSIBILITE EVALUEE SOUS HYPERCAPNIE (AUGMENTATION DU VSC DE

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30

(9875831), X. Qiu. "Studies on cartilage-derived inhibitors of angiogenesis." Thesis, 2002. https://figshare.com/articles/thesis/Studies_on_cartilage-derived_inhibitors_of_angiogenesis/13426838.

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"This work arose from anecdotal evidence for the existence of anti-angiogenic factors in shark cartilage powders. The project aimed to elucidate the mechanisms of anti-angiogenesis of shark cartilage, identify at least one novel anti-angiogenic factor from shark cartilage, and search for other natural anti-angiogenic factors in cartilage of other species." -- abstract.. This work arose from anecdotal evidence for the existence of anti-angiogenic factors in shark cartilage powders. The project aimed to elucidate the mechanisms of anti-angiogenesis of shark cartilage, identify at least one novel

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31

Mathieu, Raphaël. "L’effet de l’hyperoxie néonatale sur la néovascularisation post-ischémique à l’âge adulte." Thèse, 2018. http://hdl.handle.net/1866/22317.

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32

Blais, Martine. "L'impact des cellules souches issues de la moelle sur la néovascularisation dans un modèle de souris de rétinopathie induite par l'oxygène." Thèse, 2011. http://hdl.handle.net/1866/8368.

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La rétinopathie induite par l’oxygène (RIO) est un modèle animal semblable aux rétinopathies vue chez l’homme. Dans ce modèle, une destruction des microvaisseaux rétiniens est suivie d’une néovascularisation pathologique qui chez l’homme peut mener à un détachement de la rétine et subséquemment une perte de vision. Afin de remédier à cette revascularisation anarchique, un traitement de cellules souches (hématopoïétiques et mésenchymateuses) a été effectué chez des souris soumises à ce modèle. Les cellules injectées ont pu migrer à la rétine et induire une revascularisation saine (surtout le

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33

Hüll, Stephanie. "Gewebereaktionen auf nicht-metallische kardiovaskuläre Implantatmaterialien zum Einsatz bei der Therapie angeborener Herzfehler." Doctoral thesis, 2016. http://hdl.handle.net/11858/00-1735-0000-002B-7CBA-1.

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Bei angeborenen Herzfehlern, die bei 1 bis 1,2 % aller Lebendgeburten auftreten und so-mit die häufigste behandlungsbedürftige Organfehlbildung darstellen, kommen regelhaft kardiovaskuläre Implantate im Rahmen der chirurgischen bzw. interventionellen Therapie zum Einsatz. Hierzu zählen u. a. Shunts, Patches und Okkluder, die aus verschiedenen Implantatmaterialien hergestellt werden. Das Ziel dieser Arbeit bestand darin – basierend auf histologischen Untersuchungen – Unterschiede bzw. Gemeinsamkeiten bezüglich der Biokompatibilität nicht-metallischer Implantatmaterialien zu prüfen, da eine bewu

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