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Tesis sobre el tema "Neuronal nitric oxide synthase (nNOS)"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 4 de febrero de 2022

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1

Cheung, Nathan Yiutung. "Serotonin receptor and neuronal nitric oxide synthase expression in the rat brain : implications for MDMA toxicity." Thesis, King's College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368095.

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2

Lu, Chieh-Ju. "Neuronal nitric oxide synthase-CAPON regulation of cardiac sympathetic activity in the development of hypertension." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:1204dec9-9f09-458d-b361-c8d14589fcd1.

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The studies presented in this thesis were undertaken to investigate the cellular and molecular mechanisms responsible for sympathetic hyperactivity that is observed in the Spontaneous Hypertensive Rat (SHR) and whether these abnormalities arise even before the onset of hypertension. Moreover, selected molecular candidates related to oxidative state in cardiac autonomic signalling have been explored for their potential therapeutic effects. <b>Chapter One</b> is an overview of (i) the relevance of autonomic dysfunction in cardiovascular disease in both human and animal models, (ii) the physiolog

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3

Bird, Diane Carol. "An investigation into the role of neuronal nitric oxide synthase (nNOS) in the phencyclidine mouse model of schizophrenia." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0015/MQ57249.pdf.

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4

Barua, Anupama. "The role of neuronal nitric oxide synthase (nNOS) in ischaemia/reoxygenation-induced injury and in protection of the mammalian myocardium." Thesis, University of Leicester, 2010. http://hdl.handle.net/2381/8754.

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Background: In physiological condition, NO is produced by two constitutive NOS isoform; eNOS and nNOS. Both isoforms have specific cellular locations and although the role of eNOS in myocardial ischaemic injury and in cardioprotection has been thoroughly addressed, but the role of nNOS remains unclear. Therefore, the aims of the thesis were to: (i) investigate the role of nNOS in ischaemia/reoxygenation-induced injury, (ii) determine whether its effect is species-dependent, (iii) elucidate the relationship of nNOS with mitoKATP channels and p38MAPK, two key components of IP and (iv) investigat

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5

Balda, Mara A. "Ontogeny- and Sex-Dependent Contributions of the Neuronal Nitric Oxide Synthase (nNOS) Gene to Rewarding and Psychomotor Stimulating Effects of Cocaine." Scholarly Repository, 2009. http://scholarlyrepository.miami.edu/oa_dissertations/257.

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Multiple interactions between dopamine (DA), glutamate, and nitric oxide (NO) in mesolimbic and corticostriatal circuits suggest that NO may play a critical role in cocaine-induced behavioral and neural plasticity. Clinical and preclinical studies have revealed that females and adolescents display unique vulnerabilities to the behavioral and neurochemical effects of cocaine as a result of sex-dependent and ontogeny-dependent differences in dopaminergic systems. Thus, my research objectives were to investigate the contributions of the neuronal nitric oxide synthase (nNOS) gene, ontogeny, and g

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6

Schonhoff, Christopher M. "The Regulation of nNOS During Neuronal Differentiation and the Effect of Nitric Oxide on Hdm2-p53 Binding: a Dissertation." eScholarship@UMMS, 2000. https://escholarship.umassmed.edu/gsbs_diss/57.

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Nitric oxide is a ubiquitous signaling molecule with both physiological and pathological functions in biological systems. Formed by the enzymatic conversion of arginine to citrulline, NO, has known roles in circulatory, immune and nervous tissues. In the nervous system nitric oxide has been implicated in long-term potentiation, neurotransmitter release, channel function, neuronal protection and neuronal degeneration. Much of our work has focused on yet another role for nitric oxide in cells, namely, neuronal differentiation. During development, neuronal differentiation is closely coupled with

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7

Silva, Maria Isabel. "Distribuição de celulas imunorreativas para sintase neuronal do oxido nitrico (nNOS) no hipocampo de pombos (Columba livia) apos aprendizagem de escolha alimentar." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314142.

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Orientadores: Elenice Aparecida de Moraes Ferrari, Claudio Antonio Barbosa de Toledo<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-10T10:38:58Z (GMT). No. of bitstreams: 1 Silva_MariaIsabel_M.pdf: 1381550 bytes, checksum: 9cb336aef794086ff363f071f8040818 (MD5) Previous issue date: 2007<br>Resumo: O hipocampo exerce papel fundamental no processamento de aprendizagem e memória espaciais. Comparações das características funcionais, anatômicas e neuroquímicas do hipocampo são favorecidas por evidência oriunda de estudo

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8

Denadai, Magda Aline. "Efeitos do 7-nitroindazole, um inibidor da sintase neuronal do oxido nitrico (nNOS), sobre o condiciomaneto contextural em pombos." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314745.

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Orientador: Elenice Aparecida de Moraes Ferrari<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-11T20:16:54Z (GMT). No. of bitstreams: 1 Denadai_MagdaAline_M.pdf: 823511 bytes, checksum: 1887972f9e5047fecbd7195247b586a8 (MD5) Previous issue date: 2008<br>Resumo: O óxido nítrico (NO), um neurotransmissor não convencional, tem papel importante em processos neurobiológicos de comportamento e de memória. Sua síntese é mediada por três isoformas de sintase do óxido nítrico (NOS): a neuronal (nNOS), a endotelial (eNOS) e i

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9

Machado, Aline Vilar da Silva. "Variação circadiana da expressão da sintase neuronal de óxido nítrico (nNOS) no hipocampo e o condicionamento contextual aversivo em pombos (Columba livia)." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314744.

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Orientador: Elenice Aparecida de Moraes Ferrari<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-18T00:49:19Z (GMT). No. of bitstreams: 1 Machado_AlineVilardaSilva_M.pdf: 2487506 bytes, checksum: ec15fc1b78bef814d6d459499276cdf5 (MD5) Previous issue date: 2011<br>Resumo: A ritmicidade circadiana, expressa na alteração do comportamento e em aspectos morfofisiológicos e moleculares ao longo das 24 horas do dia, é uma das funções básicas dos organismos vivos. Os processos comportamentais e os mecanismos moleculares no hi

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10

Faria, Larissa Oliveira Melloni de 1985. "Participação da sintase neuronal de óxido nítrico (nNOS) na consolidação e reconsolidação da memória do condicionamento clássico aversivo em pombos (Columba livia)." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314128.

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Orientador: Elenice Aparecida de Moraes Ferrari<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-23T06:24:39Z (GMT). No. of bitstreams: 1 Faria_LarissaOliveiraMellonide_M.pdf: 1121073 bytes, checksum: 5a3108ca0447b5fae98988b4611d7616 (MD5) Previous issue date: 2013<br>Resumo: O óxido nítrico (NO) é um neurotransmissor não convencional o qual tem papel importante em processos neurobiológicos de comportamento e de memória. Sua síntese é mediada por três isoformas de sintase do óxido nítrico (NOS): a neuronal (nNOS), a e

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11

Tajouri, Lotfi, and n/a. "Gene Expression Analysis and Genetic Studies in Multiple Sclerosis." Griffith University. School of Health Science, 2005. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20060111.123933.

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Multiple Sclerosis (MS) is a neurodegenerative disease of the central nervous system (CNS). As part of this disorder the myelin sheath undergoes degeneration, leading to alterations in the conductivity of axons, and impaired function. The onset of the disease occurs in young adults and clinical pathology is characterised by varying severity. These include i) Relapsing Remitting MS (RR-MS), ii) Secondary Progressive MS (SP-MS) and iii) Primary Progressive MS (PP-MS). MS is more prevalent in women and accounts for more than two thirds of all MS sufferers. MS is considered to be a multifactorial

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12

van, Erp Christel. "Modifying function and fibrosis of cardiac and skeletal muscle from mdx mice." University of Southern Queensland, Faculty of Sciences, 2005. http://eprints.usq.edu.au/archive/00001521/.

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Duchenne Muscular Dystrophy (DMD) is a fatal condition occurring in approximately 1 in 3500 male births and is due to the lack of a protein called dystrophin. Initially DMD was considered a skeletal myopathy, but the pathology and consequences of cardiomyopathy are being increasingly recognised. Fibrosis, resulting from continual cycles of degeneration of the muscle tissues followed by inadequate regeneration of the muscles, is progressive in both cardiac and skeletal dystrophic muscle. In the heart fibrosis interferes with contractility and rhythm whereas it affects contractile function and c

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13

Barreiro, Portela Esther. "Study of reactive oxygen species (ROS) and nitric oxide (NO) as molecular mediators of the sepsis-induced diaphragmatic contractile dysfunction : protective effect of heme oxygenases." Doctoral thesis, Universitat Pompeu Fabra, 2002. http://hdl.handle.net/10803/7066.

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Protein nitration is considered as a marker of reactive nitrogen species formation. Heme oxygenases (HOs) are important for the defence against oxidative stress. We evaluated the involvement of the neuronal (nNOS), the endothelial (eNOS), and the inducible (iNOS) in nitrotyrosine formation and localitzation, and both the expression and funcional significance (HO inhibition and contractility studies) of HOs in sepsis-induced muscle contractile dysfunction. Sepsis was elicited by injecting rats and transgenic mice deficient in either nNOS, eNOS, or iNOS isoforms with E.Coli lipolysaccharide (LPS

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14

Chachlaki, Konstantina. "Molecular characterization of NO-synthesizing neurons and assessment of their function in the maturation of the hypothalamic - pituitary - gonadal axis." Thesis, Lille 2, 2016. http://www.theses.fr/2016LIL2S047.

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L’apparition de la puberté et la régulation de la fertilité chez les mammifères sont contrôlées par un réseau neuronal complexe, situé principalement dans l'hypothalamus, et qui converge vers les neurones synthétisant l'hormone de libération des gonadotrophines (GnRH). Ces neurones régulent la sécrétion des gonadotrophines, la croissance et le fonctionnement des gonades. Le développement correct du système à GnRH, incluant des changements rapides dans l'expression et la signalisation de l’hormone GnRH au sein de cette population clairsemée de quelques centaines de neurones, est essentiel pour

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15

Hope, Bruce Thomas. "Neuronal NADPH-diaphorase is a nitric oxide synthase." Thesis, University of British Columbia, 1991. http://hdl.handle.net/2429/30932.

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The enzyme responsible for the neuronal NADPH-diaphorase histochemical reaction was identified in rat brain by employing a variety of histochemical and biochemical techniques. The histochemical reaction catalyzes the NADPH-dependent reduction of tetrazolium dyes to colored insoluble formazans. Although the histochemical reaction has been widely employed in neuroanatomical and neuropathological studies, the identity of the enzyme responsible for the reaction has been unknown. Previous attempts to determine the identity of the enzyme have failed due to the lack of a specific biochemical assay.

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16

Padayachee, Eden Rebecca. "Neuronal nitric oxide synthase : a biomarker for Alzheimers disease : interaction of neuronal nitric oxide synthase with beta-amyloid peptides in the brain." Thesis, Rhodes University, 2011. http://hdl.handle.net/10962/d1007677.

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High levels of the amino acid arginine and low levels of the product citrulline in the cerebrospinal fluid of Alzheimer's patients could mean that there is a decrease in the enzymes that metabolize this amino acid. One such enzyme is neuronal nitric oxide synthase (nNOS). In this study, neuronal nitric oxide synthase (nNOS), sourced from bovine brain was extracted and concentrated using two methods of precipitation: poly (ethylene glycol) 20 000 (PEG) and ammonium sulphate [(NH₄)₂S0₄). These two techniques gave no increase in yield nor fold purification and hence were abandoned in favour of io

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17

McNamara, Tanner. "ENOS and nNOS contribution to reflex cutaneous vasodilation during dynamic exercise in humans." Thesis, Kansas State University, 2012. http://hdl.handle.net/2097/13788.

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Master of Science<br>Department of Kinesiology<br>B.J. Wong<br>Recent data suggests nNOS mediates the NO-component of reflex cutaneous vasodilation with passive heat stress. Our hypothesis was nNOS, but not eNOS, inhibition would attenuate reflex cutaneous vasodilation during dynamic exercise. Protocol 1: subjects performed a VO[subscript]2 peak test on a supine cycle ergometer. Protocol 2: with experimental arm at heart level subjects cycled in supine posture at 60% VO[subscript]2 peak to raise core temperature (Tc) 0.8-1.0°C (35-45 min). In protocol 2 subjects were equipped with 4 microdialy

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18

Dai, Yue. "Study of Electron Transfer through the Reductase Domain of Neuronal Nitric Oxide Synthase and Development of Bacterial Nitric Oxide Synthase Inhibitors." Cleveland State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=csu1472477836.

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19

Sobolewska-Stawiarz, Anna. "Probing the dynamics and conformational landscape of neuronal nitric oxide synthase." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/probing-the-dynamics-and-conformational-landscape-of-neuronal-nitric-oxide-synthase(82903814-5474-42e3-9339-d9a7a98ead6d).html.

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Rat neuronal nitric oxide synthase (nNOS) is a flavo-hemoprotein that catalyses the NADPH and O2-dependent conversion of L-arginine (L-arg) to L-citrulline and nitric oxide (NO) via the intermediate N-hydroxyarginine. nNOS is a homodimer, where the subunits are modular and are comprised of an N-terminal oxygenase domain (nNOSoxy) that binds iron protoporphyrin IX (heme), (6R)-5,6,7,8-tetrahydro-biopterin (H4B) and L-arg, and a C-terminal flavoprotein or reductase domain (nNOSred) that binds NADPH, FAD and FMN. Regulation of NO biosynthesis by nNOS is primarily through control of interdomain el

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20

Traynham, Christopher J. "Effects of Neuronal Nitric Oxide Synthase Signaling On Myocyte Contractile Function." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1305058816.

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21

Pierson, Shawn M. "Aspects of the transcriptional and translational regulation of nitric oxide synthase 1." Connect to this title online, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1111595828.

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Thesis (Ph. D.)--Ohio State University, 2005.<br>Title from first page of PDF file. Document formatted into pages; contains x, 156 p.; also includes graphics (some col.) Includes bibliographical references (p. 146-156). Available online via OhioLINK's ETD Center

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22

Garnaud, Pierre-Emmanuel F. "Calmodulin activation of the reductase domain of mammalian neuronal nitric oxide synthase." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/12034.

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In order to investigate the CaM activation mechanism of nNOS, the effect of the conformational changes of nNOSrd and the binding of NADP(H) on the redox potential of the flavins, cofactors were assessed for the isolated FAD and FMN sub-domains by OTTLE potentiometry. The results showed that the presence of the FAD/FMN sub-domain interface does not alter the thermodynamic properties of the redox couples involved in the catalysis. This is consistent with the fact that CaM binding has a small effect on the flavins reduction potentials. Only the FMN/FMNH<sup>·</sup> redox couple was found to be st

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23

Hartt, Gregory Thomas. "Regulation of the human neuronal nitric oxide synthase gene via alternate promoters." Columbus, OH : Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1056034844.

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Thesis (Ph. D.)--Ohio State University, 2003.<br>Title from first page of PDF file. Document formatted into pages; contains xii, 152 p. : ill., (some col.). Includes abstract and vita. Advisor: Anthony Young, Molecular, Cellular, and Developmental Biology Program. Includes bibliographical references (p. 137-150).

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24

Ngqwala, Nosiphiwe Patience. "Interaction of metallic nanoparticles with biomedical enzyme target: neuronal nitric oxide synthase." Thesis, Rhodes University, 2013. http://hdl.handle.net/10962/d1001536.

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Alzheimer's disease (AD) is the most common type of dementia characterized by intracellular appearance of neurofibrillary tangles, synaptic and neuronal loss; and extracellular accumulation of amyloid-β (Aβ) peptide in senile plaques. The initial causes leading to AD are unknown, and the available treatments are only effective at slowing the degeneration process. The accumulation of arginine in the brain of Alzheimer patients indicates a possible disruption of enzymes responsible for its metabolism. One such enzyme is neuronal nitric oxide synthase (nNOS) and controlling its activity by intera

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25

Sangüesa, Ferrer Juan F. "Modulation fonctionnelle et distribution du canal calcique Cav3. 2 : rôle de la nNOS." Montpellier 1, 2008. http://www.theses.fr/2008MON1T015.

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Le canal calcique Cav3. 2 joue un rôle capital dans de nombreux processus physiologiques, notamment dans la transmission de la douleur aigüe et chronique. Cependant, les mécanismes régulant la distribution et les propriétés de ces canaux restent encore mal connus. Au cours de ma thèse, j'ai participé au développement d'un nouveau modèle pour étudier ces mécanismes : la souris knock-in Cav3. 2-GFPécliptique. Cette souris permettra d'étudier la localisation et la dynamique de Cav3. 2 in vivo grâce à une étiquette fluorescente insérée dans la partie extracellulaire du canal. Des sites de recombin

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26

Roof, Steve. "Neuronal Nitric Oxide Synthase Signaling Contributes to the Beneficial Cardiac Effects of Exercise." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1354048916.

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27

Tang, Lifei. "Effects of Neuronal Nitric Oxide Synthase Signaling on Myocyte Contraction during Beta-Adrenergic Stimulation." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1385336408.

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28

Copp, Steven Wesley. "Enzymatic regulation of skeletal muscle oxygen transport: novel roles for neuronal nitric oxide synthase." Diss., Kansas State University, 2013. http://hdl.handle.net/2097/15512.

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Doctor of Philosophy<br>Department of Anatomy and Physiology<br>Timothy I. Musch<br>Nitric oxide (NO) is synthesized via distinct NO synthase (NOS) enzymes and constitutes an essential cardiovascular signaling molecule. Whereas important vasomotor contributions of endothelial NOS (eNOS) have been well-described, the specific vasomotor contributions of nNOS-derived NO in healthy subjects during exercise are unknown. The purpose of this dissertation is to test the global hypothesis that nNOS-derived NO is a critical regulator of exercising skeletal muscle vascular control. Specifically, we ut

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29

Kececioglu, Ekin. "Analysis Of Immunoreactivity Of Nos Isoforms (nnos, Enos, Inos) In Hippocampus Of Young Rats Classified As Good And Poor Learners." Master's thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12614994/index.pdf.

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Despite very extensive studies on molecular mechanisms of learning and memory formation it is little known about individual variation in the learning skills within a random animal population and about the differences in the brain biochemistry behind this variation. In the present study, we have focused on the expression and distribution of nitric oxide synthase (NOS), one of the molecules implemented in activity-dependent neuroplasticity, in the rat hippocampus, the structure critical for episodic memory in humans and animals. The aim of the present study was to investigate the differences in

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30

Wang, Lijun. "Gene transfer strategy to study the role of neuronal nitric oxide synthase in cardiac neurotransmission." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497136.

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31

Shabeeh, Husain. "Role of neuronal nitric oxide synthase in human vascular tone and systemic haemodynamics in vivo." Thesis, King's College London (University of London), 2014. https://kclpure.kcl.ac.uk/portal/en/theses/role-of-neuronal-nitric-oxide-synthase-in-human-vascular-tone-and-systemic-haemodynamics-in-vivo(cf1a8409-f8f6-4058-9af7-40b6c39d88ec).html.

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Endothelial and neuronal nitric oxide synthase (eNOS and nNOS respectively) are constitutively expressed in vivo. Recent data showed that selective local inhibition of nNOS reduced basal blood flow without affecting endothelial-mediated vasodilatation induced by acetylcholine or increased shear stress - suggesting that eNOS and nNOS have distinct roles in vasoregulation. This thesis aimed to investigate the role of nNOS-derived nitric oxide (NO) in the regulation of skeletal blood flow during exercise and myocardial blood flow during increased cardiac workload. At a systemic level, the role of

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32

Coelho, Camila Henriques. "Análise da inibição da óxido nítrico sintase neuronal (nNOS) na liberação de vasopressina durante sepse experimental." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/60/60135/tde-30102009-022744/.

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A fisiopatologia da sepse se caracteriza por hipotensão acompanhada de aumento da secreção de vasopressina (AVP) na fase inicial e diminuição numa fase mais tardia. Essa hipotensão é em parte devido ao aumento da quantidade de óxido nítrico, que juntamente com outros mediadores tem sua produção aumentada durante a sepse. A óxido nítrico sintase (NOS) é responsável pela síntese deste mediador, e sua isoforma neuronal (nNOS) está presente no músculo esquelético, pulmões, testículos, próstata, pele e também nos neurônios vasopressinérgicos do hipotálamo. O presente trabalho avaliou a participação

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33

Lemaire, Jean-François 1980. "Binding of Vac14 to neuronal nitric oxide synthase : characterisation of a new internal PDZ-recognition motif." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101723.

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Protein interactions mediated by PDZ domains involve specific modes of recognition. The most common type depends on the recognition of a classical peptide motif found at the very carboxyl end of the PDZ domain binding protein. Although less common, other modes of recognition have been described involving internal sequences. The best characterized involves an internal beta-finger structure that mimics the carboxyl terminus of a protein. This work describes a new PDZ domain recognition sequence, that is found internally but which does not adopt a beta-finger conformation. The sequence mediates t

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34

Welland, Andrew David. "The importance of domain-domain interactions in the regulation and activity of neuronal nitric oxide synthase." Thesis, University of Edinburgh, 2008. http://hdl.handle.net/1842/3179.

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Nitric oxide synthases (NOSs) catalyse the production of the physiological messenger molecule NO from L-arginine in a unique two step oxygenation reaction. Constitutive forms of NOS are activated by the binding of calmodulin (CaM) to a 20- amino-acid inter-domain region in the presence of calcium ions, causing inter-domain electron transfer to occur from FAD to heme via FMN. This electron transfer step involves a large scale movement of the FMN-binding domain and is influenced by a number of structural features unique to NOS which include an autoinhibitory loop, a C-terminal extension, a numbe

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35

Muszkiewicz, Anna. "Multi-scale modelling and simulations into the mechanisms linking neuronal nitric oxide synthase and atrial fibrillation." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:244d6f3a-00da-4ae8-8d5c-31ebb847806f.

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Atrial fibrillation (AF) is the most common cardiac arrhythmia. Its incidence is projected to rise due to population ageing and increasing prevalence of associated risk factors. AF alters, or remodels, the affected atrial tissue, promoting future occurrences of itself and increasing resistance to treatment. Mechanisms underlying AF initiation and remodelling are not well understood. Recent experimental evidence indicates that decreased levels of the neuronal isoform of Nitric Oxide Synthase (nNOS) may be related to AF onset and precede remodelling. However, the potential mechanisms cannot be e

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36

Xie, Jinling. "Transcriptional control via multiple promoters in the cns: glial filamin and neuronal nitric oxide synthase gene expression /." The Ohio State University, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487940665435278.

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37

Higuchi, Yoshihisa. "Increased Neurons Containing Neuronal Nitric Oxide Synthase in the Brain of a Hypoxic-Ischemic Neonatal Rat Model." Kyoto University, 1997. http://hdl.handle.net/2433/202233.

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38

Lee, Graham. "An investigation of nitric oxide synthase in neuronal function and in phencyclidine models of relevance to schizophrenia." Thesis, University of Strathclyde, 2014. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=23201.

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Schizophrenia is a complex and debilitating psychiatric disorder. Dysfunction of the NMDA subtype of glutamate receptors is implicated in deficits found in schizophrenia, and some of these deficits may be reproduced in rodents using the NMDA receptor antagonist, phencyclidine (PCP). Nitric oxide synthase (NOS) is the synthesising enzyme of the gaseous neuromodulator, nitric oxide. The neuronal isoform of NOS (nNOS) is functionally associated with NMDA receptors. The role of NOS in schizophrenia is not fully understood. The primary aim of this thesis is to investigate NOS signalling in cultured

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Candemir, Esin [Verfasser], and Andreas [Gutachter] Reif. "Involvement of neuronal nitric oxide synthase (NOS-I) PDZ interactions in neuropsychiatric disorders / Esin Candemir ; Gutachter: Andreas Reif." Würzburg : Universität Würzburg, 2018. http://d-nb.info/1162444371/34.

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Isin, Emre M. "Potential Prodrugs of the Neuronal Nitric Oxide Synthase and Monoamine Oxidase Inhibitor 7-Nitroindazole and Structurally Related Compounds." Thesis, Virginia Tech, 2000. http://hdl.handle.net/10919/35829.

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Parkinson's disease (PD) is a progressive neurodegenerative disorder of unknown cause that afflicts about 1.5 million Americans. The characteristic feature of PD is a deficiency of dopamine in the terminals of nigrostriatal neurons. Two enzyme systems, the neuronal form of nitric oxide synthase (nNOS) and monoamine oxidase B (MAO-B), have been linked to neurodegenerative pathways leading to PD. Several MAO-B and nNOS inhibitors have been evaluated for their neuroprotective properties in the mouse model of neurodegeneration which employs the parkinsonian inducing neurotoxin 1-methyl-4-phenyl-1,

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41

Ollerstam, Anna. "Macula Densa Derived Nitric Oxide and Kidney Function." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5293-0/.

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Isaak, Andreas [Verfasser]. "Neuronal nitric oxide synthase is involved in the induction of nerve growth factor-induced neck muscle nociception / Andreas Isaak." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2011. http://d-nb.info/1018200746/34.

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Mulatz, Kirk James. "A PDZ-3 mediated physical and functional interaction between the CaV3.2 T-type calcium channel and neuronal nitric oxide synthase." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/43790.

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T-type voltage-gated calcium channels are expressed throughout the central and peripheral nervous systems as well as in several non-neuronal tissues and contribute to variety of functions such as neuronal excitability, intracellular calcium influx, shaping action potentials, pace-making activity, hormone secretion, and neurotransmitter release. Of the three T-type channel isoforms, Cav3.2 is uniquely sensitive to redox modulation with oxidizing reagents inhibiting and reducing compounds enhancing channel activity. This modulation has been shown to alter firing patterns of reticular thalamic ne

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Idigo, Winifred. "Role of neuronal nitric oxide synthase in the regulation of B3- Adrenergic responses in the healthy and remodelled murine myocardium." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526494.

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Takimoto, Yoshihito. "Augmented expression of neuronal nitric oxide synthase in the atria parasympathetically decreases heart rate during acute myoccardial infarction in rats." Kyoto University, 2003. http://hdl.handle.net/2433/149374.

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Moraes, Juliana Contin. "Efeitos do fator de necrose tumoral - alfa sobre a expressão da sintase de oxido nitrico neuronal e induzivel em hipotalamo de ratos : implicações sobre o controle da fome." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310355.

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Orientador: Licio Augusto Velloso<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-06T23:35:52Z (GMT). No. of bitstreams: 1 Moraes_JulianaContin_M.pdf: 1484102 bytes, checksum: 31482341aabc46ac3c7f655aead3fbd6 (MD5) Previous issue date: 2006<br>Resumo: Durante as últimas décadas tem se observado um aumento surpreendente na prevalência de obesidade e diabetes mellitus em populações de várias regiões do mundo, inclusive no Brasil. Diversos estudos epidemiológicos apontam o consumo de dietas ricas em lípides como

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Minnaar, Estella Lily. "Regional neurochemical characterization of the flinders sensitive line rat with regard to glutamate-nitric oxide and cGMP signalling pathways / Estella Lily Minnaar." Thesis, North-West University, 2008. http://hdl.handle.net/10394/4214.

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The serious nature of MDD has intensified the need to identify and elucidate new neurobiological targets for antidepressant drug action. Depression presents with evidence for degenerative pathology that relates to disturbances in excitatory glutamatergic pathways, particularly the N-methyl-D-aspartate (NMDA) receptormediated release of the pleiotropic molecule, nitric oxide (NO), and cyclic guanosine monophosphate (cGMP). The contribution of the glutamate-NO/cGMP pathway may realize great importance as a fundamental substrate underlying the pathophysiology of major depression. In the next gene

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Karolewicz, Beata, Katalin Szebeni, Tempestt Gilmore, Dorota MacIag, Craig A. Stockmeier, and Gregory A. Ordway. "Elevated Levels of NR2A and PSD-95 in the Lateral Amygdala in Depression." Digital Commons @ East Tennessee State University, 2009. https://dc.etsu.edu/etsu-works/8607.

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Compelling evidence suggests that major depression is associated with dysfunction of the brain glutamatergic transmission, and that the glutamatergic N-methyl-d-aspartate (NMDA) receptor plays a role in antidepressant activity. Recent post-mortem studies demonstrate that depression is associated with altered concentrations of proteins associated with NMDA receptor signalling in the brain. The present study investigated glutamate signalling proteins in the amygdala from depressed subjects, given strong evidence for amygdala pathology in depression. Lateral amygdala samples were obtained from 13

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Karolewicz, Beata, Laurel Johnson, Katalin Szebeni, Craig A. Stockmeier, and Gregory A. Ordway. "Glutamate Signaling Proteins and Tyrosine Hydroxylase in the Locus Coeruleus of Alcoholics." Digital Commons @ East Tennessee State University, 2008. https://dc.etsu.edu/etsu-works/8610.

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It has been postulated that alcoholism is associated with abnormalities in glutamatergic neurotransmission. This study examined the density of glutamate NMDA receptor subunits and its associated proteins in the noradrenergic locus coeruleus (LC) in deceased alcoholic subjects. Our previous research indicated that the NMDA receptor in the human LC is composed of obligatory NR1 and regulatory NR2C subunits. At synapses, NMDA receptors are stabilized through interactions with postsynaptic density protein (PSD-95). PSD-95 provides structural and functional coupling of the NMDA receptor with neuron

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Zoerner, Frank. "Novel Interventions in Cardiac Arrest : Targeted Temperature Management, Methylene Blue, S-PBN, Amiodarone, Milrinone and Esmolol, Endothelin and Nitric Oxide In Porcine Resuscitation Models." Doctoral thesis, Uppsala universitet, Anestesiologi och intensivvård, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-236312.

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It is a major clinical problem that survival rates after out-of-hospital cardiac arrest have not markedly improved during the last decades, despite extensive research and the introduction of new interventions. However, recent studies have demonstrated promising treatments such as targeted temperature management (TTM) and methylene blue (MB). In our first study, we investigated the effect of MB administered during experi-mental cardiopulmonary resuscitation (CPR) in the setting of postponed hypother-mia in piglets. We set out to study if MB could compensate for a delay to establish targeted TTM

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