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Tesis sobre el tema "NF2/Merlin"

Autor: Grafiati

Publicado: 12 de octubre de 2024

Última modificación: 31 de julio de 2025

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1

Johnson, Kristen C. (Kristen Carrie) 1976. "Analysis of the function of the Nf2 tumor suppressor protein, Merlin." Thesis, Massachusetts Institute of Technology, 2003. http://hdl.handle.net/1721.1/29763.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2003.<br>Vita.<br>Includes bibliographical references.<br>The Neurofibromatosis type 2 tumor suppressor gene (NF2) is mutated in inherited and sporadically occurring central nervous system tumors. The NF2 encoded protein, merlin, shares close sequence similarity in its amino-terminal domain to members of the band 4.1 family of membrane-cytoskeletal linkers. Similarities between merlin and this family suggest a role for merlin in regulating cytoskeletal function. Thus, NF2 may be a novel type of tumor suppressor gene that

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2

Schulze, Karin Marlies Marion. "Herstellung rekombinanter Retroviren, In-vitro-Gentransfer und Expressionsanalyse des NF2-Gens Merlin." [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=962345210.

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3

Chen, Yaxiong. "Characterization of chicken NF2/merlin and its functions in early limb muscle development /." free to MU campus, to others for purchase, 2003. http://wwwlib.umi.com/cr/mo/fullcit?p3115532.

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4

Mani, Timmy. "The Role of Phosphoinositide Binding in Merlin Function." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1299181100.

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5

Zhan, Yu. "Mixed Lineage Kinase 3 Signaling in Ovarian Cancer and Neurofibromatosis-2." University of Toledo / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1310127039.

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6

Adès, Noémie. "PAK1 and NF2 antagonist functions in regulating central nervous system myelination : from modulation of oligodendrocyte cytoskeleton to myelin sheath formation." Electronic Thesis or Diss., Sorbonne université, 2024. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2024SORUS197.pdf.

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Dans le système nerveux central, la formation des gaines de myéline par les oligodendrocytes permet une propagation efficace et adaptée des potentiels d'action le long des axones, ainsi qu'un apport métabolique aux neurones. Le processus de myélinisation requière une fine régulation du cytosquelette d'actine des oligodendrocytes. En effet, la première étape de la myélinisation, qu'est l'extension d'un prolongement par les oligodendrocytes pour atteindre un axone, est soutenue par une polymérisation de l'actine. En revanche, l'enroulement de ce prolongement et son étalement autour de l'axone po

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7

Lyons, Rimmer Jade. "The potential of CRL4-DCAF1 and KSR1 as therapeutic targets in low-grade Merlin-deficient tumours." Thesis, University of Plymouth, 2018. http://hdl.handle.net/10026.1/12833.

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Merlin is a tumour suppressor protein that is frequently mutated or downregulated in cancer. Biallelic Merlin inactivation is causative of tumour formation, including schwannoma, meningioma and ependymoma. These tumours can occur sporadically or as part of the genetic condition Neurofibromatosis type 2 (NF2) and cause significant morbidity. The current treatment options are restricted to surgery and radiotherapy, which are invasive and may cause further tumour development. The activity of both the E3 ubiquitin ligase complex Cullin 4 really interesting new gene (RING) E3 ubiquitin ligase- DNA

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8

Worseck, Josephine Maria. "Characterization of phosphorylation-dependent interactions involving neurofibromin 2 (NF2, merlin) isoforms and the Parkinson protein 7 (PARK7, DJ1)." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16533.

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Veränderungen in phosphorylierungsabhängigen Signalwegen, Akkumulation von Proteinaggregaten im Gehirn und neuronaler Zelltod sind Neurodegenerationskennzeichen und Indikatoren für überlappende molekulare Mechanismen. Um Einblicke in die involvierten Signalwege zu erhalten, wurde mit Hilfe eines modifizierten Hefe-Zwei-Hybrid (Y2H)-Systems für 71 Proteine, die mit neurologischen Erkrankungen assoziiert sind, proteomweit nach Protein-Protein Interaktionen (PPIs) gesucht. Für 21 dieser Proteine wurden PPIs identifiziert. Das Gesamtnetzwerk besteht aus 79 Proteinen und 90 PPIs von denen 5 phospho

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9

Sperka, Tobias [Verfasser]. "Ein neuer, regulierter Komplex des NF2-Tumorsuppressor-Genproduktes Merlin mit p190RhoGAP und p120RasGAP / Forschungszentrum Karlsruhe GmbH, Karlsruhe. Tobias Sperka." Karlsruhe : FZKA, 2006. http://d-nb.info/978199979/34.

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10

Boin, Alizée. "Le rôle de la voie Hippo dans la fonction suppresseur de tumeur associée au gène NF2 et la régulation de Yap par Merlin dans les cellules de Schwann." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA112282.

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Les schwannomes sont des tumeurs bénignes se développant à partir d’une hyper-prolifération des cellules de Schwann suite à l’inactivation bi-allélique du gène NF2. Signe pathogonomique d’une pathologie rare et héréditaire, la Neurofibromatose de type 2 (NF2), ils peuvent aussi apparaître de façon sporadique. Hormis la chirurgie ou la radiothérapie, peu d’options pharmacologiques sont proposées aux patients porteurs de schwannomes, principalement à cause du peu de cibles thérapeutiques identifiées. Dans les cellules de Schwann, le phénotype cellulaire associé à la perte NF2 est une perte d’inh

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11

Schulz, Alexander [Verfasser], Reinhard [Akademischer Betreuer] Wetzker, Reinhard [Akademischer Betreuer] Bauer, and Stephan [Akademischer Betreuer] Baader. "Die Rolle des Tumorsuppressorproteins Merlin bei der Pathogenese von NF2-assoziierter Polyneuropathie / Alexander Schulz. Gutachter: Reinhard Wetzker ; Reinhard Bauer ; Stephan Baader." Jena : Thüringer Universitäts- und Landesbibliothek Jena, 2015. http://d-nb.info/1066238359/34.

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12

Worseck, Josephine [Verfasser], Christian [Akademischer Betreuer] Spahn, Erich E. [Akademischer Betreuer] Wanker, and Hans [Akademischer Betreuer] Lehrach. "Characterization of phosphorylation-dependent interactions involving neurofibromin 2 (NF2, merlin) isoforms and the Parkinson protein 7 (PARK7, DJ1) / Josephine Maria Worseck. Gutachter: Christian Spahn ; Erich E. Wanker ; Hans Lehrach." Berlin : Humboldt Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://d-nb.info/1023931621/34.

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13

Thaxton, Courtney Lynn. "Mechanisms Promoting Phosphorylation of the NF2 Tumor Suppressor and its Effects on Schwann Cell Development." Doctoral diss., University of Central Florida, 2007. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/2154.

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Neurofibromatosis type 2 is an autosomal dominant disease characterized by the formation of schwannomas and other peripheral neuropathies. The nf2 gene encodes the protein Schwannomin, or merlin. Schwannomin (Sch) is a membrane-cytoskeletal linking protein that suppresses cell proliferation at high cell density and modulates cell shape. Sch's tumor suppressive activity is regulated by its localization, conformation, and phosphorylation at serine 518 (S518). Sch's localization is dependent on binding the scaffold protein, paxillin. Phosphorylation of Sch at S518 regulates its conformation and t

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14

Provenzano, Lucy. "The role of cellular prion protein in the development of schwannomas and other Merlin-deficient tumours." Thesis, University of Plymouth, 2018. http://hdl.handle.net/10026.1/10784.

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Neurofibromatosis type 2 (NF2) is an inherited, multiple tumour disease caused by loss of the tumour suppressor protein, Merlin. There are several tumours associated with NF2 including; ependymomas, meningiomas and schwannomas. Merlin loss can also occur sporadically in all of these tumours and is associated with upregulation of various growth factor receptors and their relevant signalling pathways. At present the only treatment options for NF2 are surgery or radiosurgery, both of which incur serious morbidity and are unable to prevent recurrence of tumours. Either new drug treatments, or re-p

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15

McLain, John. "The Deletion of Exon 2 in the Nf2 Gene Leads to Changes in Morphology, Protein Expression, and Localization in Mouse Schwann Cells." Honors in the Major Thesis, University of Central Florida, 2007. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/1179.

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This item is only available in print in the UCF Libraries. If this is your Honors Thesis, you can help us make it available online for use by researchers around the world by following the instructions on the distribution consent form at http://library.ucf.edu/Systems/DigitalInitiatives/DigitalCollections/InternetDistributionConsentAgreementForm.pdf You may also contact the project coordinator, Kerri Bottorff, at kerri.bottorff@ucf.edu for more information.<br>Bachelors<br>Burnett School of Biomedical Sciences<br>Molecular Biology & Microbiology

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16

Schulze, Karin Marlies Marion [Verfasser]. "Herstellung rekombinanter Retroviren, In-vitro-Gentransfer und Expressionsanalyse des NF2-Gens Merlin / vorgelegt von Karin Marlies Marion Schulze." 2001. http://d-nb.info/962345210/34.

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