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AL-Homood, Ibrahim Abdulrazag, Iman Sheshah, Abdel Gaffar A. Mohammed y Gasim I. Gasim. "The Prevalence and Risk Factors of Osteoporosis among a Saudi Female Diabetic Population". Open Access Macedonian Journal of Medical Sciences 5, n.º 2 (8 de abril de 2017): 177–81. http://dx.doi.org/10.3889/oamjms.2017.030.
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 AIM: This study aimed to assess the prevalence and determinants of osteoporosis [lumbar spine (LS) and femoral neck (FN)] among patients with type 2 diabetes at King Salman Hospital.MATERIALS AND METHODS: One hundred seventy patients with type 2 diabetes were enrolled in this cross-sectional study in the period from the 1st of January until the 1st of July 2015. Patient selection was based on self-report of the previous diagnosis by a physician, being on an antidiabetic agent, or a fasting glucose of 126 mg/dl as per the American Diabetes Association criteria. A dual energy X-ray absorptiometry scan with the bone mineral density (BMD) categorization based on the WHO cut of levels of T-scores and determination of vitamin D levels were performed. A detailed questionnaire was used to collect demographic data.RESULTS: Out of 170 participants, 50 (29.4%) were diagnosed as having osteoporosis, while 68 (40%) were diagnosed with osteopenia. Age was determined as a risk factor for a decreased BMD in patients with osteopenia (odds ratio (OR) = 1.1, 95% confidence interval (CI) = (1.0-1.1), p = 0.039) and osteoporosis (OR = 1.1, CI = 1.0-1.2, p < 0.001). Similarly, oral hypoglycemic agents (OHA) increased the risk of decreased BMD in osteopenia (OR = 2.6; CI = 1.0-6.7; p = 0.023) as well as osteoporosis, (OR = 3.8; CI = 1.3-10.9; p = 0.013), while vitamin D deficiency increased the risk of osteopenia OR = 3.0; CI = 1.2-7.2; p = 0.012). Increased BMI decreased the risk of both osteopenia and osteoporosis (OR = 0.9; CI = 0.9-0.99; p = 0.031 vs. OR = 0.9; CI = 0.80-0.95; p = 0.003).CONCLUSION: Advanced age, OHA and vitamin D deficiency are determinants of decreased BMD in Saudi women with type 2 diabetes, while an increased BMI protects against low BMD.
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Gandhi, Shreyans, Jie Jiang, Nana Benson-Quarm, Hanna Renshaw, Syed A. Mian, Austin G. Kulasekararaj, Ghulam J. Mufti y Judith C. W. Marsh. "Telomere Length and Telomerase Assay Assist in Identifying Novel Telomere Gene Complex Mutations in a Cohort of Patients with Aplastic Anemia". Blood 126, n.º 23 (3 de diciembre de 2015): 667. http://dx.doi.org/10.1182/blood.v126.23.667.667.
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Abstract Background Shortened telomeres are seen in approximately a third of patients with idiopathic aplastic anemia (AA) and they also define risk of relapse, clonal evolution and overall survival. Constitutional pathogenic mutations in the telomere gene complex (TGC) are associated with very short telomeres (typically <1st centile) and may also present with AA, but have important implications in terms of different management strategies, especially with conditioning regimen and donor selection for bone marrow transplantation, which in turn affect transplant outcomes. Furthermore, detection of mutations of the TGC complex then entail regular screening/review of organ/systems affected in telomere disease, counselling and health insurance with regards to the increased risk of cancer and screening of family members. Novel variants affecting telomere function are increasingly being reported but in the absence of a full telomere disease phenotype, unaffected family members or variable penetrance of the mutant in affected family members, there remains uncertainty as to whether some are pathogenic or represent polymorphisms. Methods We report results using telomere length (TL) measurement by quantitative-real time PCR (qPCR) as a screening tool to identify patients for further mutation analysis on a customised panel of 10 TGC genes (TERT, TERC, DKC1, TINF2, NHP2, NOP10, RTEL1, CTC1, USB1 and WRAP) using deeply parallel sequencing in a cohort of patients with AA. Using a Polyphen score that predicts a variant to be possibly pathogenic, we have used telomere repeat amplification protocol (TRAP) assay to increase the robustness of classifying a variant as more likely pathogenic, where family history was unrevealing. TRAP assay was performed by introducing the variants into W138V13 cell line and comparing telomerase expression in them to wild type TERT and TERC expression of telomerase. Results From the King's College Hospital database, we screened 295 patients with AA for TL using qPCR. The median age of the cohort was 44.2 years (range18.2- 83.4) with male/female ratio of 57:43. 189 patients (64%) had TL < 10th centile and 111 (37.6%) had TL <1st centile (Figure 1). We screened 215 of these patients for TGC mutation analysis and report 40 mutations (18.6%) in this cohort. Most mutations were in the reverse transcriptase enzyme TERT (n=33) and the remaining in the catalytic unit of the RNA complex TERC (n=7). A positive family history of bone marrow failure was seen in only 4 (10%) of these cases with TGC mutation, where the same TGC mutation was detected. 38/40 (95%) patients with a TGC mutation had a TL <10th centile and 32 (80%) had TL<1st centile. 32/111 (28.8%) of AA patients with TL<1st centile were found to have a TGC mutation, while only 6/78 (7.8%) of AA patients with 10th < TLth centile had TGC mutations. We identified a further 9 novel variants which were predicted to be possibly pathogenic, but have not been reported pathogenic in literature, as yet. All 9 patients with the novel variants had TL <1st centile with a median age of 37 (range 19-62), but had no positive family history of bone marrow failure or features of telomere disease. Using the TRAP assay, all 9 variants had telomerase activity well below 50% of WT TERT and TERC telomerase expression. All TERC variants had TRAP score of ~20% and 5 of the 6 TERT variants had TRAP score of <30% of WT TERT telomerase activity, of which 3 had telomerase activity <5% (Figure 2). Conclusion Two thirds of patients with AA have TL <10 th centile. Most patients with a TGC mutation have TL <1st centile. TL can reliably be used as a screening tool to investigate patients for further TGC mutation analysis. Heterozygous state mutation in TERT are the commonest, followed by TERC and explain the slightly late onset (mid 40's) and milder presentation of telomere disease as compared to the more severe phenotype and younger presentation classically seen with the homozygous state DKC mutations. A telomere length and a TRAP assay can add value in predicting a possible or putative pathogenic variant in a TERT or TERC gene on TGC analysis, where a reliable family history of telomereopathy is lacking. Figure 1. Telomere length expressed as T/S ratio against age for the different cohorts Figure 1. Telomere length expressed as T/S ratio against age for the different cohorts Figure 2. Expression of telomerase activity in novel TERT and TERC variants compared to Wild-type (positive control) and Mock (negative control) Figure 2. Expression of telomerase activity in novel TERT and TERC variants compared to Wild-type (positive control) and Mock (negative control) Disclosures Kulasekararaj: Alexion: Consultancy.
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Stacey, Robin Chapman. "Kings of Celtic Scotland.Benjamin T. Hudson". Speculum 70, n.º 4 (octubre de 1995): 917–18. http://dx.doi.org/10.2307/2865379.
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Khattab, T. M., A. A. Atra, S. K. Felimban y C. Fryer. "Advances in management of childhood acute leukemia (AML, ALL): Experience at a developing country, National Guard hospital, western region of Kingdom of Saudi Arabia". Journal of Clinical Oncology 25, n.º 18_suppl (20 de junio de 2007): 20020. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.20020.
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20020 Background: The outcome of children with acute myeloid leukemia (AML) has improved over last two decades. The main factors behind this are increasing intensity of chemotherapy and improved measures of supportive care. While white blood cell count and age are major factors for risk classification in childhood acute lymphoblastic leukemia (ALL), therapy remains the single most prognostic factor. Objectives: To assess survival with each regimen of chemotherapy and causes of treatment failure. Methods: we retrospectively reviewed the details of treatment and outcome of all children with AML from 1986- 2005 (20 yr.) and ALL from 1989–2003 (15yr.) at King Abdulaziz Medical City, Jeddah, Saudi Arabia. Results: AML 54 patients, 23 boys with median age 5 yr. (range 0.5–14 yr.). Five (9%) had CNS leukemia. Between 1986–1995, 22 pts were treated with BFM based chemotherapy, remaining 32 received UK-AML 10 between 1996–2005. 8/22 (36%) & 5/32 (16%) died of toxicity and 12 (54%) and 8 (25%) died of AML during 1st & 2nd era respectively. With a median follow up of 3 year (.5–10 yr.). The overall survival is 9% in 1st era and 59% in 2nd era. ALL 297 patients were registered. Male 165 pts., median age 5 yr. (range 1–14), WBCs >50,000x109, 55 pts. (19%). T-cell 36 (12%), pre-B 222 (75%) and 29 (10%) unknown. NCI risk classification according to age & WBCs count at presentation as HR 84 (28%), SR 204 (69%). Causes of death; 50/297 (17%) disease recurrence which failed 2nd line chemotherapy, 12/297 (4%) induction death and 11/297 (4%) died of toxicity. Survival by different regimens of chemotherapy were showing UKALL-X 1989–1993, 67 pts.as 55%; UKALL-XI/BFM (1994–1998) 98 pts. As 72%; MRC-97/CCG1991 (1999–2003) 132 pts.87% as overall 5 yr survival. Conclusions: This single center study confirmed that the outcome of children with AML/ALL has improved over last decade. Increasing local experience, advances in supportive care and chemotherapy have contributed to this improvement. No significant financial relationships to disclose.
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Zhang, Guo Li, Ya Nan Wang, Jia Lu Li, Guang Wei Chen, Li Chen y Fu You Wang. "The Effect of Reinforcement Structure on the Modal Parameters for Sandwich Structure Composite Plate". Advanced Materials Research 194-196 (febrero de 2011): 2420–24. http://dx.doi.org/10.4028/www.scientific.net/amr.194-196.2420.
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In order to investigate the effect of different reinforcement structure on the dynamic characteristics of sandwich structure composite plates used for manufacturing the high speed reciprocating motion composite components, four kinds of paulownia wood sandwich composite test specimens with dimensions of 350×83.5×9.5mm was designed and made by hand lay-up performing and press molding technology. The woven and 2D braiding fabric prepreg were both selected as top face and inner face materials , respectively, and the carbon fiber woven fabric prepreg was chosen as inner part materials. According to the impulse response modal test method, a modal test system was established. It was found that this kind of sandwich structure composite plate has bigger natural frequency value, it’s minimum natural frequency was about 609.77Hz that could meet the requirement for high speed reciprocating motion parts. The dynamic test results shown that the natural frequency of F2BAF-IUC-CPW sample is higher t about 11.17% at least, selecting 2D integral braiding pipe fabric as top face and inner face reinforced materials could effectively improve the dynamic properties of sandwich composite rectangular plates. The modal experiments indicated that the modal shapes of sandwich composite plate specimen with four kind reinforcement structures were identical, it’s 1st modal shape, 2nd modal shape and 3rd modal shape presented torsional vibration shape, flexural vibration shape and torsional flexural vibration shape, separately, the modal shapes of sandwich composite plate specimen were not obviously affected by reinforcement structure.
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Hantono, Dedi, Yuanita F. D. Sidabutar y Ully I. M. Hanafiah. "KAJIAN RUANG PUBLIK KOTA ANTARA AKTIVITAS DAN KETERBATASAN". LANGKAU BETANG: JURNAL ARSITEKTUR 5, n.º 2 (27 de diciembre de 2018): 80. http://dx.doi.org/10.26418/lantang.v5i2.29387.
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Ruang esensinya adalah tempat manusia hidup dan beraktivitas. Namun tidak semua aktivitas dapat terakomodir karena setiap ruang dibatasi dengan fungsinya masing-masing. Bagi ruang pribadi keterbatasan ruang tersebut merupakan karakteristik utama bagi ruang itu sendiri sedangkan pada ruang publik yang memiliki berbagai macam aktivitas harus dapat menampung berbagai aktivitas di dalamnya. Untuk itulah perlu dilakukan kajian mengenai ruang publik terhadap permasalahan keterbatasan ruang yang sering ditemui. Tulisan ini menggunakan metode kualitatif dengan melakukan pendekatan kajian literatur. Ada beberapa literatur yang diambil dari beberapa ahli serta beberapa hasil penelitian dalam artikel jurnal untuk mendukung teori dan melihat kenyataan di lapangan. Pada akhir tulisan diambil suatu kesimpulan bahwa keterbatasan ruang publik terhadap berbagai macam aktivitas yang berlangsung di dalamnya dengan terbentuknya ruang bersama baik secara permanen maupun bergantian (waktu tertentu).Kata-kata Kunci: arsitektur, ruang publik, aktivitas, ruang bersamaURBAN PUBLIC SPACE STUDIES BETWEEN ACTIVITIES AND LIMITATIONSThe essence of space is a place where humans live and doing their activities. But not all activities can be accommodated because space is limited by their functions. For private space, space limitations are the main characteristics for space itself, while in public spaces that have various kinds of activities must be able to accommodate multiple activities in it. For this reason, a study of public space needs to be done on the problems of space limitations that are often encountered. This paper uses qualitative methods by conducting a literature review approach. There is some literature taken from several experts and several research results in the journal for support the theory and see the reality in the field. At the end of the writing, it was concluded that the limitations of the public space for various kinds of activities take place in it with the formation of shared spaces both permanently and alternately (certain times).Keywords: architecture, public space, activity, share spaceREFERENCESAgustapraja, H. R. (2018). Studi Pemetaan Perilaku (Behavioral Mapping) Pejalan Kaki Pada Pedesterian Alun-Alun Kota Lamongan. Civilla, 3(1), 134–139. https://doi.org/https://doi.org/10.30736/cvl.v3i1.220Athanassiou, E. (2017). The Hybrid Landscape Of Public Space In Thessaloniki In The Context Of Crisis. Landscape Research, 42(7), 782–794. https://doi.org/10.1080/01426397.2017.1372399Carr, J., & Dionisio, M. R. (2017). Flexible Spaces as a Third Way Forward for Planning Urban Shared Spaces. In Cities (pp. 73–82). Elsevier. https://doi.org/10.1016/j.cities.2017.06.009Carr, S., Francis, M., Rivlin, L. G., & Stone, A. M. (1992). Public Space. New York: Cambridge University Press.Farida, N. (2013). Effect of Outdoor Shared Spaces on Social Interraction in a Housing Estate in Algeria. Frontiers of Architectural Research, 2, 457–467. https://doi.org/10.1016/j.foar.2013.09.002Hakim, R., & Utomo, H. (2003). Komponen Perancangan Arsitektur Lansekap: Prinsip-Unsur dan Aplikasi Desain. Jakarta: Penerbit Bumi Aksara.Hanafiah, U. I. M., & Asharsinyo, D. F. (2017). Redefenisi Ruang Publik Pada Kampung Kreatif Pasundan. Studi Kasus: Koridor Tepian Sungai Cikapundung, RT 02 RW 04, Kelurahan Balonggede, Kecamatan Regol, Kota Bandung, Jawa Barat. Idealog, 2(2), 124–137. https://doi.org/10.25124/idealog.v2i2.1220Hantono, D. (2017). Pengaruh Ruang Publik Terhadap Kualitas Visual Jalan Kali Besar Jakarta. Arsitektura, 15(2), 532–540. https://doi.org/10.20961/arst.v15i2.15114Krier, R. (1979). Urban Space. New York: Rizzoli.Liem, Y., & Lake, R. C. (2018). Pemaknaan Ruang Terbuka Publik Taman Nostalgia Kota Kupang. Arteks, 2(2), 149–158. https://doi.org/10.30822/artk.v2i2.150Mulyandari, H. (2011). Pengantar Arsitektur Kota. (Oktaviani HS, Ed.) (1st ed.). Yogyakarta: Penerbit Andi.Murtini, T. W., & Wahyuningrum, S. H. (2017). Penggunaan Ruas Jalan Sebagai Pasar Tradisional Di Gang Baru Pecinan, Semarang. Modul, 17(1), 17–21. Retrieved from https://ejournal.undip.ac.id/index.php/modul/article/view/17246/12396Olesen, M., & Lassen, C. (2012). Restricted Mobilities: Access to, and Activities in, Public and Private Spaces. International Planning Studies, 17(3), 215–232. https://doi.org/10.1080/13563475.2012.704755Rapoport, A. (1990). The Meaning of the Built Environment: A Nonverbal Communication Approach (1st ed.). Arizona: University of Arizona Press.Rochimah, E., & Asriningpuri, H. (2018). Adaptasi Perilaku Pedagang Bazar Dalam Teritori Ruang Dagang. Nalars, 17(1), 21–28. https://doi.org/10.24853/nalars.17.1.21-28Salomon-Ayeh, B. E., King, R. S., & Decardi-Nelson, I. (2011). Street Vending and The Use of Urban Public Space in Kumasi, Ghana. Surveyor, 4(1), 20–31. Retrieved from http://dspace.knust.edu.gh/bitstream/123456789/3423/1/Surveyor Journal 3.pdfSantoso, J. T., Mustikawati, T., Suryasari, N., & Titisari, E. Y. (2016). Pola Aktivitas Wisata Belanja dI Kampung Wisata Keramik Dinoyo, Malang. Tesa Arsitektur, 14(1), 1. https://doi.org/10.24167/tes.v14i1.560Simpson, P. (2011). Street Performance And The City: Public Space, Sociality, And Intervening In The Everyday. Space and Culture, XX(X), 1–16. https://doi.org/10.1177/1206331211412270Sudarisman, I. (2017). Kajian Pedagang Kaki Lima Di Taman Tegalega, Bandung, Jawa Barat. Arsir , 1(2), 161–174. Retrieved from http://jurnal.um-palembang.ac.id/arsir/article/view/867/769
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Imran, Iffat, Nusrat Zareen Bashir, Umber Fatima, Imran Nazir, Rizwan Rasul Khan y Muhammad Ajmal Farid. "Correlation of different obstetrical factors with hemoglobin level in pregnant females." Professional Medical Journal 27, n.º 03 (10 de marzo de 2020): 625–30. http://dx.doi.org/10.29309/tpmj/2020.27.03.3901.
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Objectives: To assess the correlation of different obstetrical factors with the hemoglobin level in multiparous pregnant females in Taif KSA. Anemia in pregnancy is a multifactorial phenomenon, among which obstetrical factors like parity, previous H/O abortions, inter pregnancy interval, mode of delivery etc are frequently associated. Study Design: Observational study. Setting: Outpatient department in King Faisal Hospital (KFH), Taif, Saudi Arabia. Period: 1st June 2018 and 31st August 2018. Material & Methods: Conducted in 200 pregnant women by random sampling technique. Hemoglobin value and all patient’s data was noted. All data was fed to SPSS version 23.0 and statistically analyzed using chi square test for qualitative and student’s t test for quantitative data. Results: The study was conducted in 200 patients that showed that there was no statistically significant association of increasing parity, inter pregnancy interval, mode of delivery (NVD or Cesarean section) & history of anemia and PPH in preceding pregnancy with the Hemoglobin level. While history of previous abortion is associated and a risk factor for anemia in pregnancy, 50% with history of 01 previous abortion had anemia while 100% of the cases with history of 02 previous abortions had moderate anemia. (Table-II). This association was observed statistically significant with p value of 0.001. Conclusion: This study concluded that anemia is a predictable as well as preventable entity. Obstetrical factors may be the contributory factors of anemia in pregnancy. Health education awareness programs, regular antenatal visits and iron supplements can be helpful to improve heath of pregnant women.
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Liaquat, Ahmad, Arun Kumar Shah y Nabeela Riaz. "Auricular Cartilage Interposition Arthroplasty in Recurrent Temporomandibular Joint Ankylosis in Pediatric Patients". Journal of Islamabad Medical & Dental College 10, n.º 1 (31 de marzo de 2021): 323–28. http://dx.doi.org/10.35787/jimdc.v10i1.545.
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Background: Temporomandibular joint (TMJ) ankylosis in early childhood can lead to disturbances in growth, facial asymmetry and difficulties in eating as well as in breathing. The objective of the study was to evaluate the effectiveness of auricular cartilage as an interpositional material after gap arthroplasty in pediatric patients with temporomandibular joint ankylosis in maintaining the achieved postoperative mouth opening.
Material and Methods: This prospective study was conducted at the Oral and Maxillofacial Surgery Department of King Edward Medical University, Lahore, from 1st January 2019 to 30th November 2019. Thirty patients, aged 5 to 15 years with clinical and radiological diagnosis of TMJ ankylosis were included in the study. TMJ ankylotic mass was removed, the gap was created and interposition of auricular cartilage graft was done in these patients. Mouth opening was measured as a distance between the incisal edges of mandibular central incisors to maxillary central incisors using the scale. Preoperative and postoperative mouth opening was noted and compared using the paired t-test.
Results: Among the thirty patients, 19 were male and 11 were female. The mean (±SD) age of patients was 9.23±3.23 years (age range 5 to 15 years). The mean preoperative mouth opening (T1) was 7.3±3.1 mm, while the mean postoperative mouth opening (T2) was 29.2±3.3 mm. The mean interincisal distance was 29.0 mm (range 21 mm to 35 mm). The mean difference in pre- and postoperative mouth opening (T2-T1) was 21.6 ± 5 mm.
Conclusions: Autogenous auricular cartilage graft is an efficient and reliable interpositional material for achieving early postoperative mouth opening in TMJ ankylosis patients.
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Lawson, Jack N. "A. Graeme Auld: Kings without privilege: David and Moses in the story of the Bible's kings, x, 203 pp. Edinburgh: T&T Clark, 1994. £16.95." Bulletin of the School of Oriental and African Studies 58, n.º 3 (octubre de 1995): 544–45. http://dx.doi.org/10.1017/s0041977x00012994.
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Johnstone, William. "Kings without Privilege: David and Moses in the Story of the Bible's Kings. By A. Graeme Auld. Edinburgh, T.&T. Clark, 1994. Pp. x + 203. £21.95." Scottish Journal of Theology 50, n.º 2 (mayo de 1997): 256–58. http://dx.doi.org/10.1017/s0036930600036073.
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Bamdad, C., A. K. Stewart, P. Huang, B. J. Smagghe, S. Moe, T. Swanson, T. Jeon, D. Page, K. Mathavan y T. Grant. "1st-in-human CAR T targets MUC1 transmembrane cleavage product". Cytotherapy 22, n.º 5 (mayo de 2020): S33—S34. http://dx.doi.org/10.1016/j.jcyt.2020.03.021.
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McKay, Rana R., Scott C. Flanders, Christine Ferro, Kate Fitch, Michael Fabrizio y Michael Thomas Schweizer. "Overall survival (OS) among Medicare beneficiaries receiving sipuleucel-T (sip-T) versus oral treatment for metastatic castration-resistant prostate cancer (mCRPC)." Journal of Clinical Oncology 38, n.º 6_suppl (20 de febrero de 2020): 42. http://dx.doi.org/10.1200/jco.2020.38.6_suppl.42.
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42 Background: Since the mCRPC treatment landscape is evolving, we examined real-world use and outcomes of sipuleucel-T (sip-T) and oral agents (abiraterone acetate and enzalutamide) in men with mCRPC. Methods: Using Medicare FFS Identifiable Research data, we identified mCRPC men with a qualifying prostate cancer diagnosis (ICD-9 185, ICD-10 C-61) and an initial treatment claim (abiraterone, cabazitaxel, docetaxel, enzalutamide, radium 223, sip-T) in 2014. Continuous Part A, B, and D eligibility and no HMO enrollment was required through 2017 or until death. mCRPC index date is the date of a mCRPC therapeutic claim. Using 4 groups (sip-T first line, oral first line, sip-T any line, and oral any line [no sip-T]), survival was estimated using Kaplan-Meier methods (unadjusted). Hazard ratios (HR) were estimated using Cox’s proportional hazards regression modeling. Results: During 2014, 14,482 eligible men had mCRPC drug claims. We studied 6,853 naïve mCRPC men with no treatment claim in the prior 12 months. Over 150 permutations of anti-cancer agents were identified. See table for patient characteristics. Sip-T was used 2+ line in 4.5% of men receiving orals 1st. Median overall survival was longer for men who received sip-T, regardless if used 1st line (35 mo) or in any line (35 mo), compared with oral 1st line use (21 mo) or an oral any time without sip-T (21 mo). Similar survival was seen after adjusting for baseline opioid use. While most received sip-T as 1st line, survival rates were higher in men receiving sip-T in any line (48%) compared to men who never received any sip-T (29%). Conclusions: In this analysis, sip-T use was associated with a 45% reduction in risk of death and 14 mo survival benefit in the Medicare FFS population regardless of when used. Real-world analyses like this provide insight into how to optimize sip-T use to treat prostate cancer.[Table: see text]
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Kuheba, Jefier Andrew, Joachim N. K. Dumais y Paulus A. Pangemanan. "PERBANDINGAN PENDAPATAN USAHATANI CAMPURAN BERDASARKAN PENGELOMPOKAN JENIS TANAMAN". AGRI-SOSIOEKONOMI 12, n.º 2A (1 de julio de 2016): 77. http://dx.doi.org/10.35791/agrsosek.12.2a.2016.12601.
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The objective of research is to compare how much the average income per hectare of farms mixture by grouping types of plants in the Airmadidi Bawah Village. This research was conducted in the Airmadidi Bawah urban village for 3 months, from September to November 2015 with the method of data collection by using primary data. Samples taken were 15 for each farming mix using cluster random sampling technique. To determine the ratio mix used farm income analysis tool SPSS by using t-test. The results showed that there were significant differences between 1st mixed farming with 2nd mixed farming; the average income per hectare of 1st mixed farming Rp. 35.921.389,- was higher than the average income per hectare of 2nd mixed farming Rp. 30.430.699,- Results of testing the hypothesis 1st mixed farming and 2nd mixed farming shows the t-test (4.910) > t-table (1,761). From the test results, Ho is rejected and H1 is accepted, it means that there are differences in the average income per hectare of the 1st mixed farming and 2nd mixed farming.jnkd
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Tsao, Raymond E., Bill Richendollar, Tony Jin, Eric Hsi y Brad Pohlman. "Prognostic Value of Tumor-Infiltrating TIA-1+ Cytotoxic T Cells (TIA1-CTCs) and FOXP3+ Regulatory T Cells (Tregs) in Post-Transplant Lymphoproliferative Disorder (PTLD) Following Solid Organ Transplant (SOT)." Blood 110, n.º 11 (16 de noviembre de 2007): 54. http://dx.doi.org/10.1182/blood.v110.11.54.54.
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Abstract Background: PTLD is a rare, often fatal, complication of SOT. Several studies have identified clinical prognostic factors in PTLD. However, no published studies to our knowledge have yet correlated outcome with the number (#) or type of tumor infiltrating T-cells, which in other types of lymphoma may have prognostic value. We hypothesized that tumor infiltrating T-cells, including TIA1-CTCs and Tregs, would predict survival in SOT PTLD. Methods: We searched the Cleveland Clinic pathology archives for SOT patients (pts), who were diagnosed with PTLD between 1987 and 2007; reviewed the medical records and extracted clinical information and outcomes; performed immunohistochemical (IHC) studies for CD3, TIA-1, and FOXP3; and analyzed the data by Cox proportional univariate and multivariate analyses. Results: We identified 62 SOT pts (heart, 22; lung, 17; kidney 15; liver, 7; pancreas, 1), who were diagnosed with PTLD at median age of 51 years (range 7–73). The median time from SOT to PTLD was 1.8 years (range 0.2–20.9). 1st therapeutic intervention (1st TI) (usually >1) included “complete” resection (4), decreased immunosuppression (51), acyclovir or gancyclovir (32), rituximab (R) (18), “CHOP” chemotherapy (11), radiation therapy (7), and interferon (4). Response to 1st TI was CR (34) or PR (10). The median follow-up among surviving pts is 3.6 years (range 0.1–11.7). 35 (including 4 CHOP and 9 R) pts have died; only 2 CHOP but all 9 R pts died from PTLD. IHC studies in 42 evaluable cases showed the following median # (and range) of cells /10 hpf: CD3 525 (8–2451), TIA1-CTCs 304 (6–1238) and FOXP3 13 (1–338). On univariate analysis, younger age, prior rejection episodes <2, PS <2, LDH normal, extranodal sites (ENS) <2, IPI <4, 1st TI >1, 1st TI with CHOP, # of CD3 cells >550/10 hpf, and # of TIA1-CTCs >300/10 hpf were associated with an improved overall survival (OS), PTLD-specific survival (PSS), and/or progression-free survival (PFS). On multivariate analyses, only PS <2, ENS <2, and 1st TI with CHOP remained independent predictors of outcome. Among the subset of 47 pts with monomorphic B-cell (MMBC) PTLD, these same clinical factors were also independently statistically significant. Conclusions: High #s of infiltrating T cells and TIA1-CTCs are associated with a favorable outcome and may reflect a relatively intact local anti-tumor response. Tregs, which may potentially antagonize such a response, are uniformly low and do not correlate with outcome in PTLD. In this analysis, a significant minority of SOT pts treated initially with single agent R still died from PTLD while pts treated initially with CHOP (with or without R) appeared to have a better outcome, arguing for its early use - at least in a subset of pts. Future studies should attempt to identify biological factors that predict which MMBC PTLD pts might benefit from the addition of CHOP to standard R as part of 1st TI.
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Stacey, Robin Chapman. "Prophecy of Berchán: Irish and Scottish High-Kings of the Early Middle Ages.Benjamin T. Hudson". Speculum 73, n.º 1 (enero de 1998): 190–92. http://dx.doi.org/10.2307/2886909.
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Clancy, Thomas Owen. "Benjamin T. Hudson, Kings of Celtic Scotland, Contributions to the Study of World History 43". Peritia 13 (enero de 1999): 341–45. http://dx.doi.org/10.1484/j.peri.3.383.
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Salama, Heba Sabry Attia. "Yield and nutritive value of maize (Zea mays L.) forage as affected by plant density, sowing date and age at harvest". Italian Journal of Agronomy 14, n.º 2 (5 de junio de 2019): 114–22. http://dx.doi.org/10.4081/ija.2019.1383.
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The current study was carried out in Alexandria, Egypt and investigated the effect of sowing date; 1st May, 1st July, and 1st September 2017 and 2018, and age at harvest; 45, 55 and 65 days after sowing (DAS) on yield and quality of maize green forage grown with three plant densities (120, 160, and 200 kg ha–1). Sowing at 1st of May produced the highest significant amount of fresh yield (41.51 t ha–1 in average). Sowing at 1st of July resulted in the production of significantly lower yield (24.54 t ha–1 in average), however, higher dry matter content (175.99 g kg–1 in average), compared to sowing at 1st of May (143.62 g kg–1 in average). A pronounced increase in fresh yield was observed when maize was harvested at 55 DAS (30.89 t ha–1 in average) compared to harvesting at 45 DAS (22.92 t ha–1 in average). Meanwhile, the increase in fresh yield from 55 DAS to 65 DAS was non-significant. The effect of sowing date on quality parameters was greatly dependent on the age of plant at harvest. Harvesting maize green forage at 65 DAS, reflecting an advanced stage of maturity, caused a significant reduction in the crude protein (CP), and a significant increase in the neutral and acid detergent fibre fractions (NDF and ADF), resulting in a decline in the digestible organic matter (DOM). Plant density exerted non-significant influence on the fresh yield and DM content, minimal effect on the CP content, while the effect on the NDF and ADF contents was dependent on the age at harvest. The lignin content (ADL) of the herbage significantly decreased with increasing the plant density. Variations in the DOM were most dependent on the variations in CP content, followed by the variations in ADF and ADL contents. In conclusion, it is recommended to grow green forage maize twice a season on the 1st of May and 1st of July, with intermediate plant density (160 kg ha–1), and harvest it not later than 55 DAS to achieve the optimum balance between herbage productivity and nutritive value.
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Affandi, Maemunah, Bambang Madiyono, Sutarto H. y Asikin Hanafiah. "Electrocardiographic Pattern in the Newborn During the First Week of Life". Paediatrica Indonesiana 16, n.º 3-4 (13 de septiembre de 2019): 59–70. http://dx.doi.org/10.14238/pi16.3-4.1976.59-70.
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One hundred and sixteen babies were given electrocardiogram examination on the 1st day until the 7th day of birth as well as the examination at 3 and 6 months.
There were definite changes in the heart rate, P duration, PR interval, T axis, and T wave of the right precordial leads on the 1st day, especially on the 1st hours of birth. These changes may be caused by physiological adjustment after birth and anatomical changes like the closing of foramen ovale and ductus arteriosus. There were changes on the second day and thereafter caused by increased activities of the left side of the heart. Observations were made on ECG examination on fullterm normal babies on the 1st week of birth. Genetic factors should not be ignored (Sutin and Schrire, 1964) as data gathered in this study have shown some differences from data gathered in other studies.
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Revenko, E. M. y V. A. Salnikov. "THE EFFECT OF MOTIVATION ON THE MOTOR ACTIVITIES OF STUDENTS UNDER DIFFERENT PHYSICAL EDUCATION APPROACHES". Education and science journal 20, n.º 8 (2 de noviembre de 2018): 112–28. http://dx.doi.org/10.17853/19945639-2018-8-112-128.
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Introduction.Motivation of pupils is the principal aspect in successful physical education. One of the main objectives of a physical-education teacher is to create in pupils a strong desire to consciously and voluntarily carry out regular physical exercises and develop the potential to work independently.Theaimof the research was to show the influence of various approaches to the organization of sports activities on motivation leading to physical activity in young men aged 16–18.Methodology and research methods. The methodological base of the research involved a personally-oriented educational concept combining differentiated and kinesiological approaches to physical education. The research was carried out in phases using annual and longitudinal tests to evaluate students’ knowledge and skills. Levels of general intelligence were estimated using the I-S-T 2000R test as adapted by L. A. Yasyukova. Formal-dynamic characteristics of individuality were studied using the method developed by V. M. Rusalov. In order to evaluate motivation for the realization of motor activity, a specially-designed questionnaire was used. IBM SPSS Statistics 22 and Microsoft Excel software programs were employed for statistical processing of primary experimental material.Results and scientific novelty.A comparative analysis of the personal characteristics of senior school students and 1st year students (177 people) identified heterochronism in the development of standard motive and mental abilities of young people. It was observed that a lack of synchronism in the formation of separate functional systems in an organism causes a different attitude of school students to physical exercises implemented through an integrated program and standard approach without taking into account individual characteristics of young men. As compared with their peers, motivation to sport activities is initially higher among pupils with higher motor function. A formative level of general intelligence is lower due to students’ potential success when performing a wide complex of activities required by the physical culture curriculum. However, allowing free choice in sport specialization significantly increases the motivation of young people who are physically weaker but who are more intellectually developed than their peers.Practical significance. The research outcomes serve as scientific justification for the more extensive introduction of sports-oriented approach into educational institutions when organizing physical education. A sports-oriented approach is focused on preferences and interests of each student. The approach provides a free choice of the most attractive kinds of activity which gives a feeling of satisfaction and self-confidence, and consequently, enhances motivation to physical selfimprovement through visiting fitness centres and gyms which, in turn, will ensure good health in the future.
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Reeves, Nicholas. "An Amarna-period ostracon from the Valley of the Kings". Antiquity 75, n.º 289 (septiembre de 2001): 501–2. http://dx.doi.org/10.1017/s0003598x00088645.
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The Amarna Royal Tombs Project (ARTP) initiated its programme of archaeological survey and excavation in the central part of Egypt’s Valley of the Kings in November 1998, and has now completed three successive seasons of work under the joint field-direction of Nicholas Reeves and Geoffrey T. Martin. The emphasis to date has been on the documentation and investigation of the ancient settlements which once occupied much of the central Valley — those neglected ‘workmen’s huts’ which previous excavators have occasionally noted, sometimes ‘cleared’, and more rarely planned. A particular focus of ARTP’s work has been that area of settlement located between tombs KV 56 (‘The Gold Tomb’) and KV 9 (Ramesses VI), which in the early years of the 20th century was partially explored both by Theodore Davis (who left little record: cf. Davis 1908: 31) and by Howard Carter (Carter & Mace 1923: 87; cf. Reeves 1990a: plate XIV Reeves & Wilkinson 1996: 84). The greater part of this restricted site — a good deal of its archaeology still intact, despite earlier sondages — has now been excavated down to bedrock, with intriguing results.
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Sarkar, R. K., J. C. Jana y S. Datta. "Effect of different sowing times and spacings on growth, yield and quality of water spinach (Ipomoea reptans Poir.) under terai region of West Bengal". Journal of Applied and Natural Science 6, n.º 2 (1 de diciembre de 2014): 489–94. http://dx.doi.org/10.31018/jans.v6i2.488.
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An experiment was conducted to find out suitable sowing time and spacing as to increase the production of both green and seed yield and its quality of water spinach (Ipomoea reptans Poir.) during the year 2007-08 and 2008-09. The experiment was comprised of three sowing times (1st week of May; 1st week of June and 1st week July) and three spacings (30 cm × 15 cm; 30 cm ×30 cm and 30 cm ×45 cm). It was found that early sowing on 1st week of May and closest spacing of 30 cm ×15 cm alone and their combination executed best results with respect to all parameters. The sowing on 1st week of May with closest spacing of 30 cm ×15 cm produced about 3.26 times higher green yield (18.83 t/ha). On the other hand, sowing on 1st week of June with 30 cm ×15 cm spacing contributed 52.95 percent higher seed yield (0.78 t/ha). All the seed quality testing parameters viz. shelling percentage (62.53), 1000 seed weight (40.56 g), germination percentage (82.40), seedling vigour index (5.38) and seedling growth rate (0.091 g/plant/day) were observed to be highest in 1st week of June with widest spacing of 30 cm ×45 cm. On economic point of view, the combination of 1st week of May along with 30 cm ×15 cm spacing was noticed to be superior amongst all other treatment combinations and that may be adopted for its commercial cultivation in medium to upland situation under terai region of West Bengal.
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Fokt, Krzysztof. "Górnołużyccy villici w pierwszej połowie XIII wieku: włodarze, sołtysi czy wójtowie?" Krakowskie Studia z Historii Państwa i Prawa 6, n.º 1 (2013): 1–29. http://dx.doi.org/10.4467/20844131ks.13.001.1156.
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Upper Lusatian villici: stewards, town iudices or territorial advocati? The text deals with the problem of the proper interpretation of the institution of villicus, mentioned in Upper Lusatia in the 1st half of the 13th century. The article discusses all the hitherto attempts to identify the actual nature of the Upper Lusatian villici and proposes some new interpretations. The close relations of those villici with chartered towns (namely: Zgorzelec/Görlitz and Ostritz) and the virtual lack of royal estates around them makes it possible to state that they were not, as most scholars have claimed, royal stewards taking care of estates administered directly by the Bohemian kings (in Upper Lusatia such goods probably barely existed at all). Therefore, the most probable interpretation of the villici seems to be the one presented in 1923 by J. Bauermann, who identifi ed them with the sculteti hereditarii of particular towns.
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Locke, Frederick Lundry, Nancy L. Bartlett, Caron A. Jacobson, Olalekan O. Oluwole, Javier Munoz, Lazaros J. Lekakis, Max S. Topp et al. "Retreatment (reTx) of patients (pts) with refractory large B-cell lymphoma with axicabtagene ciloleucel (axi-cel) in ZUMA-1." Journal of Clinical Oncology 38, n.º 15_suppl (20 de mayo de 2020): 8012. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.8012.
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8012 Background: Axi-cel, an autologous anti-CD19 chimeric antigen receptor (CAR) T cell therapy, is approved in the US and EU for pts with relapsed/refractory large B cell lymphoma after ≥ 2 prior therapies. In the ZUMA-1 pivotal study (NCT02348216), the objective response rate (ORR) was 83% (58% complete response [CR] rate; Locke et al. Lancet Oncol. 2019). While axi-cel has demonstrated durable responses in a subset of pts, approximately half of all responders relapsed, and little is known on the viability of reTx with CAR T cell therapy. Here we report outcomes of pts retreated with axi-cel in ZUMA-1. Methods: Pts with progressive disease (PD) were eligible for reTx if there was no evidence of CD19 loss by local review, and if during 1st Tx they did not experience any dose-limiting toxicities, as defined in Phase 1, or comparable toxicities in Phase 2. Pts received the same regimen at reTx as at 1st Tx: 2 × 106 CAR T cells/kg after conditioning chemotherapy. Results: Thirteen pts in Cohorts 1 – 4 received axi-cel reTx. Prior to 1st Tx, most pts (69%) had an IPI score 3-4, 85% had disease stage 3-4, and the median number of prior regimens was 3 (range, 2 – 6). At first Tx, 6 pts achieved a CR, 6 achieved partial response (PR), and 1 pt had stable disease (SD) prior to PD. Median duration of first response was 96 days (range, 56 – 274). There was no Grade ≥ 3 cytokine release syndrome (CRS; 6 pts each had Grade 1 and 2). There were no Grade 4 or 5 neurologic events (NEs; 2 pts had Grade 1, 1 had Grade 2, and 7 had Grade 3). Upon reTx, 54% of pts achieved response (4 CR, 3 PR). Response to reTx was more common among pts who achieved CR at 1st Tx (83%; 4/6 CR, 1 PR, 1 SD) than in pts who achieved PR at 1st Tx (33%; 2/6 PR, 1 SD, 3 PD), and no response was observed in the pt with SD at 1st Tx. Median duration of response at reTx was 81 days (range, 1 – 225+). Response with reTx was longer than that with 1st Tx for 2 pts. One pt remains in response 255 days post-reTx. Comparable rates of CRS were observed with reTx as with 1st Tx. Compared with 1st Tx, fewer pts experienced NEs with reTx, and those that did occur were of lower grade: 23% (3 of 13 pts) had Grade 3; 23% (3 of 13 pts) had Grade 1, and 8% (1 of 13 pts) had Grade 2. Peak CAR T cell expansion was lower upon reTx vs 1st Tx (median, 4.3 vs 66.1 CAR gene-marked cells/µL blood). Conclusions: Based on this limited sample size, reTx with axi-cel may have clinical efficacy, although transient, in some pts, especially those who achieve CR with 1st Tx. CAR T cell expansion and severe CRS and NEs may be attenuated at reTx. Further studies with additional pts are needed to confirm these results. Clinical trial information: NCT02348216 .
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Bischof, Christian H. y Henry Strauss. "1st European Workshop on Hypercube and Distributed Computers". Parallel Computing 13, n.º 1 (enero de 1990): 127–29. http://dx.doi.org/10.1016/0167-8191(90)90126-t.
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Murzin, V. Yu. "THE NOMARCHES BOTHER ME…". Archaeology and Early History of Ukraine 31, n.º 2 (25 de marzo de 2019): 134–39. http://dx.doi.org/10.37445/adiu.2019.02.10.
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This article is a kind of response to the work of T. M. Kuznetsova, in which she argues that a reliable indicator of the burials of Scythian «kings» and nomarhs is the presence of bronze boilers in the grave goods.
We are still confident that quite definitely we can select from the total mass of Scythian burials only the tombs of the supreme «kings» of Scythia (and not so much by the presence of boilers, but by other signs) and the burials of ordinary Scythians.
It is impossible to isolate the burials of the Scythian «younger kings» and nomarchs from a significant array of funerary monuments of the highest Scythian aristocracy, including by the presence of boilers.
This is explained by the fact that the social and property status of the nomarchs, depending on the number of soldiers in his nome, as well as the nobility of this unit of the Scythian horde, were very different. All the foregoing applies to younger kings as well. Moreover, the nomarch, who was at the head of one of the nomes (tribes) of the Scythians-royals, could surpass the «younger king», who led the least privileged wing («kingdom») of the Scythian nomadic community.
And if we consider that the highest Scythian aristocracy could include military leaders, who became famous not for their nobility, but for military victories, as well as assistants to the supreme king (in the current language — advisors), who had management experience, and others whose functions we can only guess, the picture that emerges is quite variegated, so we hardly ever succeed to understand it, due to the limitedness of our knowledge.
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Jacevic, Vesna, Aleksandra Bocarov-Stancic, Radmila Resanovic, Viktorija Dragojevic-Simic, Ana Vukajlovic, Snezana Djordjevic y Dubravko Bokonjic. "Histochemical evaluation of T-2 toxin-induced cardiotoxicity in rats: Semiquantitative analysis". Zbornik Matice srpske za prirodne nauke, n.º 116 (2009): 67–73. http://dx.doi.org/10.2298/zmspn0916067j.
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In this study female Wistar rats were treated with T-2 toxin (1 LD50 0.23 mg/kg sc) and sacrificed on days 1, 3, 5, 7, 14, 21, 28 and 60 after the treatment. Control groups of rats were treated by saline (1 ml/kg 0.9% NaCl). At each time-schedule, control groups of animals were sacrificed, too. Pathohistological alterations of the heart were evaluated in whole visual fields stained by haematoxylin and eosin (HE), periodic acid- -Schiff's (PAS), Masson-Trichrom's (MT) and Giemsa (GIM) methods. The changes observed were scored by using semiquantitative grading scale. The heart alterations detected in T-2 toxin-treated animals ranged from focal parenchymal or hyaline degeneration (HE = 2.5 - 4.0; p < 0.05 vs. control) to diffuse necrosis of muscle cells (HE = 5.0; p < 0.05 vs. control and 1st day after T-2 treatment). The myofibrils were slightly PAS-positive during the first week of the study (PAS = 2.0 - 3.2; p < 0.05 vs. control and 1st day after T-2 treatment), while a diffuse distribution of glycogen granules in endo- and perimisium were observed from day 21 to 60 in the whole heart' tissue (PAS = 4.0; p < 0.05 vs. control and 1st day after T-2 treatment). Massive hemorrhagic foci associated with diffuse accumulation and degranulation of MCs were the most intensive from day 28 to 60 of the study (MT = 5.0; p < 0.05 vs. control and 1st day after T-2 treatment). During the whole study period, irregular distribution of glycogen granules, intensity and total number of haemorrhages were in correlation with the degree of heart structural lesions, which showed the highest coefficient of correlation (r = 0.8750; p < 0.001). Our results indicate that basic histohemical methods can be a useful tool for evaluation of T-2 toxin-induced cardiac damage, which is probably a result of complex inflammatory mechanisms, eventually leading to vascular lesions and myocardial necrosis, as well as for some potential cardioprotectors in the future.
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Hurvitz, Sara A., Annie Guerin, Melissa G. Brammer, Ellie Guardino, Zheng-Yi Zhou, Michael S. Kaminsky, Eric Q. Wu y Deepa Lalla. "Comprehensive investigation of adverse event (AE)-related costs in patients with metastatic breast cancer (MBC) treated with first- and second-line chemotherapies." Journal of Clinical Oncology 30, n.º 15_suppl (20 de mayo de 2012): 1037. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.1037.
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1037 Background: MBC is incurable and managed with ongoing therapy. This study examined the incremental costs of chemotherapy-associated AEs in MBC. Methods: The PharMetrics Integrated Database (2000-2010) was used to identify MBC pts treated either 1st or 2nd line with a taxane (T) (paclitaxel or docetaxel) or capecitabine (C)-based regimen for ≥30 days (defined as a treatment episode (TE)). Incremental costs attributable to AEs were assessed by comparing costs incurred during TEs with and without AEs. AEs were identified using medical claims with a diagnosis for ≥1 event of interest (e.g., infections, fatigue, anemia, neutropenia). Pt characteristics were balanced between comparison groups (with and w/o AEs) using inverse probability weighting method. Incremental monthly costs due to AEs were estimated during the TEs and included the following cost components: inpt (IP), outpt (OP), emergency room (ER), other medical service, pharmacy costs (chemotherapy and other drugs), and total healthcare costs. Statistical comparisons were conducted using Wilcoxon tests. Results: 3,222 women (mean age=57) received a T or C as 1st or 2nd-line therapy for MBC. Of the 2,678 1st-line pts, 69.7% received T and 30.3% with C; average monthly total costs ranged from $9,159 to $10,298. AEs were commonly seen in pts treated with 1st-line T and C (94.6% and 83.7%). On average, the total monthly incremental cost associated with AEs was 38% higher ($3,547) for T and 9% higher ($854) for C. IP and other drug costs accounted for a majority of these costs. Of 1,084 2nd-line pts, 66% received T and 34% C, with average monthly total costs ranging from $5,950 to $12,979. 94.4% of T pts and 84% of C pts in the 2nd-line had an AE. The average total monthly incremental cost associated with AEs for T was $5,320 and $4,933 for C (69.5% and 82.9% higher vs pts w/o AEs). Pharmacy costs accounted for a majority of increased costs seen in pts with AEs treated with T; IP and OP accounted for a majority of these costs in pts treated with C. Conclusions: This is the 1st study assessing costs associated with AEs for tx of mBC. AEs are associated with a substantial economic burden that is mainly explained by increased IP, OP, and pharmacy costs.
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Maj-HES, Agnes, Reza-Thierry Elaidi, Jacques Medioni, Florian Scotte, Gero Kramer, Wolfgang Hoeltl, Julie Gachet, Corine Teghom, Yohan Gornadha y Stephane Oudard. "What is the benfit of mTOR inhibitors (mTORi) rechallenge in metastatic renal clear cell carcinoma (mRCC) patients (pts) initially treated with TKI?" Journal of Clinical Oncology 30, n.º 5_suppl (10 de febrero de 2012): 442. http://dx.doi.org/10.1200/jco.2012.30.5_suppl.442.
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442 Background: question regarding the benefit of a mTORi re-challenge for pts treated with a previous line of TKI and 1 line of mTORi remains unanswered in mRCC. Methods: this study retrospectively investigated Treatment Duration (TD), best overall response (OR) in pts treated with TKI and mTORi in a sequence temsirolimus-everolimus (T-E) or everolimus-temsirolimus (E-T). Eligibility criteria: TKIs prior to either sequence of mTORi. Pts characteristics and prognostic factors (Heng’s score) were considered prior to TKI and 1st mTORi. Response was defined with respect to TD and best OR: E: Non Responders (NR): < 4.9 months (m) + progressive disease (PD), Responders (R): >4.9m + SD/PR; T: Non Responders (NR): < 3.6 months (m) + PD; Responders (R): >3.6 m + SD/PR. Results: 12 pts were eligible. 5 and 7 pts received 1 and 2 TKIs prior to 1st mTOR, respectively. 9 and 3 pts were in the intermediate and poor risk group respectively prior 1st mTORi (Heng’s score). 7 pts received E and 5 pts received T as first mTORi. Whatever the sequence, 7 pts out of 12 were responders to E and 2 out of 12 were responders to T (3 pts did not respond to any mTORi). In the E-T sequence, 5 pts were responders to E with no response to T, 1 pt no responder to E but responder to T (1 pt didn’t respond to both mTORi). In the T-E sequence, 2 pts were responders to E, 1 pt was responder to T and 2 pts didn’t response to both mTORi. Median TD for E-T and T-E sequences was 10.3m (95%CI: 8.8-19.2) and 5.8m (95%CI: 2.9-19.3), respectively. Response was not related to pt’s prognosis group. Conclusions: despite the small effective of this study, results suggest that responders to everolimus as 1st mTORi could not benefit from a re-challenge with temsirolimus. Pts who were not responders to temsirolimus could still be responders to everolimus. This observation should be confirmed with larger databases and prospective studies. [Table: see text]
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Radivoyevitch, Tomas, Rainer K. Sachs, Robert Peter Gale, Mikkael A. Sekeres, Jaroslaw P. Maciejewski, Matt Kalaycio y Sudipto Mukherjee. "Estimating Therapy-Related Myeloid Neoplasm Risks in the US". Blood 124, n.º 21 (6 de diciembre de 2014): 2617. http://dx.doi.org/10.1182/blood.v124.21.2617.2617.
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Abstract Background: Therapy-related myeloid neoplasms (t-MN) have traditionally been a dreaded but rare complication arising from the treatment of other cancers. With rising numbers of long-term cancer survivors, there is growing concern for increasing rates of t-MN. We provide estimates of the relative risks of developing these secondary cancers after various 1st cancers. Methods: We used the Surveillance Epidemiology and End Results (SEER) data 1973-2011 and the R package SEERaBomb to examine 33 primary cancer risks of subsequent MN defined as acute myeloid leukemia (AML), chronic myeloid leukemia (CML), chronic myelomonocytic leukemia (CMML), or myelodysplastic syndromes (MDS). First time cancer survivor person-years at risk (PY) for developing a second cancer were computed based on age-at-diagnosis of the first cancer, survival time, and age at diagnosis of any second cancer. Individual PY age intervals were stacked using R objects of class GRanges and the function coverage() of the Bioconductor package GenomicRanges. This yielded PY that we multiplied into age specific incidence rates computed using all t-MN regardless of being 1st, 2nd or later cancers. This yielded cases expected under a null hypothesis of t-MN being independent of prior cancers. Relative risks (RR) were then computed as observed/expected (O/E) cases and ordered by lower limit ([O - 2sqrt(O)]/E) distances from 1. PY and t-MN were restricted to those arriving after 1/1/2006 to avoid MDS incidence transients that arose immediately after its introduction into SEER in 2001. Results: 2,361 white females (Table 1), 3,415 white males (Table 2), 239 African American (AA) females (Table 3), and 309 AA males (Table 4), had t-MN diagnosed after 1/1/2006 that were known to have occurred at least 1 year after the 1st cancer. In these tables/results: RR after non-Hodgkin lymphoma (NHL), Hodgkin's disease (HD), and multiple myeloma (MM) was high, save MM in AA males; high risks after acute lymphocytic leukemia (ALL) and brain cancer were not significant for 1st cancers diagnosed >15 years of age, so these are due to childhood 1st cancers; and high risks of 2nd MN after a 1st are largely due to progressions being classified as 2nd cancers. Conclusion: t-MN with histories of NHL, HD, and MM may be enriched for truly treatment-induced cases. Mechanistic studies of t-MN should focus on such patients. Table 1. t-MN in White Females 1st Cancer O E RR ALL 16 0.6 27.4 (13.7, 41.1)* MN 99 13.3 7.5 (6, 9) NHL 235 60 3.9 (3.4, 4.4) Hodgkin's 23 4.3 5.3 (3.1, 7.6) MM 39 9.4 4.2 (2.8, 5.5) Ovarian 91 32.1 2.8 (2.2, 3.4) Brain 11 3.2 3.5 (1.4, 5.6) Lung 113 65 1.7 (1.4, 2.1) Breast 791 579.5 1.4 (1.3, 1.5) CLL 34 17.4 2 (1.3, 2.6) Other 56 31.8 1.8 (1.3, 2.2) *RR ~95% confidence intervals are given in parentheses Table 2. t-MN in White Males 1st Cancer O E RR MN 180 17.8 10.1 (8.6, 11.6) ALL 14 0.9 15.1 (7, 23.2) Hodgkin's 42 6.4 6.6 (4.5, 8.6) NHL 344 69.6 4.9 (4.4, 5.5) MM 57 13.8 4.1 (3, 5.2) CLL 77 25.2 3.1 (2.4, 3.8) CIS 243 111.2 2.2 (1.9, 2.5) Head & Neck 31 11.3 2.7 (1.8, 3.7) Lung 130 71.5 1.8 (1.5, 2.1) Other 60 29.5 2 (1.5, 2.6) Testes 29 11.9 2.4 (1.5, 3.3) Brain 14 4.6 3.1 (1.4, 4.7) Oral 75 41.6 1.8 (1.4, 2.2) Bladder 215 158.9 1.4 (1.2, 1.5) Prostate 1331 1054.8 1.3 (1.2, 1.3) Rectal 93 64.2 1.4 (1.1, 1.7) Stomach 24 13.2 1.8 (1.1, 2.6) Table 3. t-MN in AA Females 1st Cancer O E RR MN 20 1.2 16.2 (8.9, 23.4) Hodgkin's 7 0.4 17.9 (4.4, 31.5) MM 10 2.2 4.6 (1.7, 7.5) Ovarian 9 1.8 5 (1.7, 8.3) NHL 11 3.2 3.5 (1.4, 5.6) Breast 73 41.6 1.8 (1.3, 2.2) CIS 34 21.2 1.6 (1.1, 2.2) Table 4. t-MN in AA Males 1st Cancer O E RR MN 14 0.8 17.9 (8.3, 27.4) NHL 20 2.4 8.4 (4.6, 12.1) Prostate 166 92.1 1.8 (1.5, 2.1) Other 8 1.7 4.7 (1.4, 8) CIS 9 2.3 4 (1.3, 6.6) Hodgkin's 5 0.4 11.8 (1.2, 22.4) Lung 13 4.7 2.8 (1.2, 4.3) Renal 10 3.2 3.1 (1.2, 5.1) Head & Neck 5 0.5 10.8 (1.1, 20.4) Disclosures Sekeres: Celgene: Membership on an entity's Board of Directors or advisory committees; Amgen Corp: Membership on an entity's Board of Directors or advisory committees; Boehringer-Ingelheim Corp: Membership on an entity's Board of Directors or advisory committees.
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WORMALD, PATRICK. "Benjamin T. Hudson, Kings of Celtic Scotland. Greenwood Press, Westport Conn., 1994. xvii + 195 pp., £49.50." Innes Review 46, n.º 2 (diciembre de 1995): 170–72. http://dx.doi.org/10.3366/inr.1995.46.2.170.
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Halpern, Baruch. "Word Biblical Themes: 1, 2 Kings T. R. Hobbs Dallas: Word Books, 1989. xiv + 104 p". Studies in Religion/Sciences Religieuses 20, n.º 1 (marzo de 1991): 123–24. http://dx.doi.org/10.1177/000842989102000120.
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Kowolik, Claudia M., Sergio Gonzalez, Simon Olivares, Michael Jensen y Laurence J. N. Cooper. "CD28-Costimulation Provided through a CD19-Specific Chimeric Immunoreceptor Enhances In Vivo Persistence and Anti-Tumor Efficacy of Adoptively Transferred T Cells." Blood 106, n.º 11 (16 de noviembre de 2005): 1278. http://dx.doi.org/10.1182/blood.v106.11.1278.1278.
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Abstract Adoptive transfer of T cells expressing chimeric immunoreceptors into cancer patients holds promise for the eradication of tumor cells. Chimeric immunoreceptors can redirect T cells to clinically important targets such as cancer cells or virally infected cells. Current adoptive immunotherapy trials with genetically modified T cells use chimeric antigen receptors (CAR’s) that connect an extracellular antigen-recognizing domain to a single intracellular signal transduction domain such as CD3-ζ. These CAR’s stimulate genetically modified T cells for lysis and cytokine production, but typically do not provide a fully-competent activation signal. Thus, when we expressed a 1st-generation CD19-specific chimeric receptor (CD19R), the genetically modified T cells demonstrated (i) antigen-specific binding, (ii) target-cell lysis in vitro and (iii) anti-tumor efficacy in vivo, but failed to produce IL-2 upon antigen recognition and exhibited a short survival (less than 10 days) in vivo. Fully-competent activation of T cells requires a second signal, typically provided by the simultaneous engagement of co-stimulatory receptors such as CD28 along with the T-cell resceptor. Since many B-lineage tumors lack or down-regulate the co-stimulatory ligands for CD28 (CD80, CD86), we designed a 2nd -generation CD19-specific immunoreceptor, designated CD19RCD28, that includes the intracellular signaling domains of CD28 and CD3-ζ. We then compared the in vitro and in vivo immunobiology of CD19-specific T cells expressing these 1st or 2nd generation CAR’s. When tested by chromium release assays both CD19R+ and CD19RCD28+ T cells were able to specifically lyse CD19+ tumor cells at a comparable efficiency. However, CD19RCD28+ T cells were able to produce IL-2 and up-regulate the anti-apoptotic protein Bcl-XL upon stimulation with CD19+ tumor cells unlike the CD19R+ T cells. Moreover, CD19RCD28+ T cells can be efficiently propagated ex vivo via the CD19-specific CAR over sequential stimulation cycles when cultured with CD19+ Epstein-Barr virus (EBV) transformed B-lymphoblastic cells. Using a biophotonic imaging system and T cells co-expressing the firefly luciferase (ffLuc) reporter gene we determined that 2nd-generation CD8+ CD19RCD28+ffLuc+ T cells persisted significantly longer in NOD/scid mice (in the absence of exogenous rhIL-2) compared with 1st-generation CD19R+ffLuc+ T cells, as measured by longitudinal bioluminescence imaging (BLI). Since these mice were engrafted with Renilla luciferase (rLuc)+ CD19+ tumor, we were able to directly correlate the presence of T cells with an anti-tumor effect, as measured by BLI of rLuc activity (Figure). Furthermore, the continued persistence of the CD19RCD28+ T cells was dependent on the presence of antigen, as adoptive transfer of CD19RCD28+ T cells could not be detected beyond 5 days by BLI in mice without tumor. Taken together, these findings demonstrate that incorporation of chimeric CD28 and CD3-ζ signaling domains in CAR’s provides a tool to increase T-cell persistence leading to improved anti-tumor efficacy. Figure- Adoptive transfer of 1st or 2nd generation CD19-specific T cells in mice with established rluc+ tumor Figure-. Adoptive transfer of 1st or 2nd generation CD19-specific T cells in mice with established rluc+ tumor
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Hasegawa, Takashi, Kotaro Saito, Vu Van Lien, Takashi Miyagawa, Akiko Kubota y Takashi Yokochi. "Life history of Chrysozephyrus alienus (Koiwaya & Monastyrskii, 2010) (Lepidoptera) in central Vietnam". TAP CHI SINH HOC 39, n.º 3 (15 de mayo de 2017): 291–95. http://dx.doi.org/10.15625/0866-7160/v39n3.9348.
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We have successfully reared the larvae of Chrysozephyrus alienus (Koiwaya & Monastyrskii, 2010), and presented the life history of this species. The larval foodplant was found to be Lyonia ovalifolia var. pubescens. The tactile setae of the 1st instar larvae are absent at dorsal anterior area at the 1st abdominal segment and dorsal area at the 7th abdominal segment. The pattern is rather similar to that of Chrysozephyrus scintillans. Citation: Hasegawa T., Saito K., Vu Van Lien, Miyagawa T., Kubota A., Yokochi T., 2017. Life history of Chrysozephyrus alienus (Koiwaya & Monastyrskii, 2010) (Lepidoptera) in central Vietnam. Tap chi Sinh hoc, 39(3): 291-295. DOI: 10.15625/0866-7160/v39n3.9348. *Corresponding author: airsjapan64@gmail.com Received 20 March 2017, accepted 20 August 2017
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Pavlić, Ivana, Barbara Puh y Ljubica Mišković. "The perception of travellers and the World Heritage Site image". Tourism 68, n.º 2 (8 de junio de 2020): 181–94. http://dx.doi.org/10.37741/t.68.2.6.
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The paper investigates the main image determinants of World Heritage Site (WHS) among different types of travellers. The main purpose is to define the main features of different types of travellers (tourists and cruise ship visitors) and to determine the attributes that create their particularly perceived image of WHS. In order to gain the main aims, empirical research, based on questionnaire on randomly–chosen travellers visiting WHS, was carried. The sample consisted of 547 tourists and 472 cruise ship visitors who visited WHS - Old city of Dubrovnik (OCD) in the period April 1st – October 1st 2016. Research spatial framework consists of multiple-use protected area with buffer zone. Explorative factor analysis (EFA), confirmatory factor analysis (CFA), and structural equation modelling (SEM) were applied. The results show that there are differences between image formation among different types of travellers regarding cognitive and affective image elements. The obtained results can be used as a base model for investigating the influence of the information sources, socio-demographics and motivation on mediating ones (cognitive and affective evaluation), and finally on the dependent variable of the overall image of the WHS perceived by different traveller categories.
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Jannah, Khuzaimatul, Kadek Suranata y Ni Ketut Suarni. "Keefektifan konseling kognitif behavioral dengan teknik restrukturisasi kognitif untuk meningkatkan endurance siswa". Psychocentrum Review 1, n.º 2 (17 de octubre de 2019): 59–68. http://dx.doi.org/10.30998/pcr.1279.
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This study aims to determine the effectiveness of cognitive behavioral counseling with cognitive restructuring techniques to improve endurance of 1st grade students at SMA Negeri 4 Singaraja. This experimental study used the Pretest Posttest Control Group Design. The study population was students of 1st grade SMA Negeri 4 Singaraja. The research sample consisted of 54 students. Through random sampling, 23 students were placed in the experimental group and 31 students were the control group. Data collection in this study used a questionnaire. The data in this study were analyzed by independent samples t-test using JASP Version 0.7.5.5 and d’Cohen for calculate level of effectiveness. The results t = 8.577 with p= 0.001, then p <0.05. Effect Size (ES) testing shows a high level of effectiveness (ES = 2.361). These results prove that cognitive behavioral counseling with cognitive restructuring techniques is effective for improving the endurance of 1st grade students at SMA Negeri 4 Singaraja.
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Ding, X., B. Patel, X. Song, J. Syh, J. Syh, J. Zhang, D. Freund, L. Rosen y H. Wu. "SU-E-T-188: Commission of World 1st Commercial Compact PBS Proton System". Medical Physics 42, n.º 6Part14 (junio de 2015): 3375. http://dx.doi.org/10.1118/1.4924549.
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IMAI, Keiko y Eisuke NAITO. "The 1st Regional Workshop on S&T Information Dissemination in South EastAsia". Journal of Information Processing and Management 42, n.º 9 (1999): 753–64. http://dx.doi.org/10.1241/johokanri.42.753.
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BROUN, DAUVIT. "Kings of Celtic Scotland. By Benjamin T. Hudson. Pp. xvii, 195. Westport, Connecticut: Greenwood Press. 1994. £49.50." Scottish Historical Review 75, n.º 2 (octubre de 1996): 247–49. http://dx.doi.org/10.3366/shr.1996.75.2.247.
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McCarthy, Carmel. "Book Review: 1.2 Kings. By T. R. Hobbs. Word Biblical Themes, Dallas, Texas, 1989. Pp. 104. npg". Irish Theological Quarterly 59, n.º 4 (diciembre de 1993): 315–16. http://dx.doi.org/10.1177/002114009305900408.
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Sekiya, Yuko, Atsushi Narita, Nao Yoshida, Kimikazu Matsumoto y Koji Kato. "Outcomes of Hematopoietic Stem Cell Transplantation for Childhood Acute Lymphoblastic Leukemia with t(4;11)". Blood 118, n.º 21 (18 de noviembre de 2011): 4502. http://dx.doi.org/10.1182/blood.v118.21.4502.4502.
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Abstract Abstract 4502 Introduction: As the prognosis of childhood acute lymphoblastic leukemia (ALL) with t(4;11) is generally poor, hematopoietic stem cell transplantation(HSCT) at 1st complete remission is recommended in most of Japanese ALL protocol. We analyzed outcomes of HSCT for childhood ALL with t(4;11) at our department, and assessed the outcomes with age and preconditioning at HSCT. Subjects: We retrospectively analyzed 15 patients who underwent HSCT between 1991 and 2011. The onset of ALL was less than one year old (infant ALL) in 9 patients and over one year old in 6 patients. The disease status at HSCT was 1st complete remission (CR1) in 10 patients, 2nd complete remission (CR2) in 2 patients, and more advanced stages in 3 patients. 13 patients underwent allogeneic HSCT and 2 patients underwent autologous HSCT at median age of 19 months. In allogeneic HSCT, the number of bone marrow transplantation from HLA matched sibling was 3 and 4 from unrelated donors, and that of cord blood transplantation was 6. Nine patients including 7 infant ALL underwent conventional stem cell transplantation (CST), 6 patients including one infant ALL underwent reduced intensity stem cell transplantation (RIST). Preconditioning of RIST was mostly consisted of fludarabine and melphalan with 3Gy of total body irradiation (TBI). Results: Of all 15 patients, 8 patients are alive in CR. Three out of 9 infant ALL and 5 out of 6 ALL patients, whose onset was above 1 year old, are alive in CR. Seven of 10 ALL patients who underwent HSCT in 1st CR are alive, on the other hand, only one of 5 patients in 2nd CR or non CR is alive. Five patients who underwent RIST over 1 year old are alive in CR. Discussion: HSCT for childhood ALL with t(4;11) in 1st CR could achieve better outcome than those in 2nd CR or non CR. The transplant outcomes with RIST was better than CST and it could be applied for ALL patients with t(4;11) whose onset is over one year old. Disclosures: No relevant conflicts of interest to declare.
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Weller, Michael, Ekaterina Terksikh, Manuela Silginer, Carsten Krieg, Patrick Roth, Burkhard Becher y Hans-Georg Wirsching. "Association of peripheral blood CD4+ T-cell depletion under temozolomide with inferior survival of patients with IDH wildtype glioblastoma." Journal of Clinical Oncology 38, n.º 15_suppl (20 de mayo de 2020): 2548. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.2548.
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2548 Background: Standard first line chemoirradiation with temozolomide is associated with distinctive peripheral blood immune cell profiles in IDH wildtype glioblastoma. Whether such profiles at recurrence are associated with survival has not been studied in detail. Methods: Peripheral blood mononuclear cells of 21 healthy donors and of 91 patients with IDH wildtype glioblastoma were analyzed by flow cytometry at 1st recurrence. Patients received either (i) standard chemoirradiation with temozolomide (TMZ) followed by dose-intensified TMZ at first recurrence within the phase II trial DIRECTOR (N = 52) or (ii) hypofractionated radiotherapy with or without bevacizumab (N = 39) followed by investigators’ choice within the phase II trial ARTE. Patients were classified based on unsupervised analyses of PBMC profiles at 1st recurrence. Associations with survival were explored in multivariate Cox models controlling for established prognostic and predictive factors. Results: At 1st recurrence, two patient clusters were identified in the DIRECTOR cohort which differed in CD4+ T-cell fractions, but not with respect to CD8+ T-cells, CD4+;CD25+;FoxP3+ regulatory T-cells, B-cells or monocytes. The composition of CD4+, CD8+ or regulatory T-cell fractions was similar in both clusters. All control samples clustered with the CD4high cluster. Patients in both clusters did not differ by established prognostic factors, including age, O6-methylguanine-DNA-methyl-transferase ( MGMT) gene promoter methylation, tumor volume, Karfnosky performance score or steroid use. Progression-free survival was similar (CD4high vs CD4low 2.1 vs 2.4 months, p = 0.19), whereas post-recurrence overall survival was longer among the CD4high cluster (12.7 vs 8.7 months, p = 0.004). At 2nd recurrence after dose-intensified TMZ re-challenge, monocyte fractions increased, whereas memory CD4+ T-cell fractions decreased. Higher memory CD4+ fractions were associated with longer overall survival at 2nd recurrence (p = 0.004). The reported associations were retained in multivariate Cox models controlling for established prognostic factors. In the ARTE cohort, CD4+ T cell fractions at 1st recurrence did not differ compared to diagnosis (p = 0.91) and there were no associations with bevacizumab (p = 0.28) or survival (p = 0.74), supporting that the effects observed in the DIRECTOR cohort were driven by TMZ. Conclusions: We conclude that TMZ-associated memory CD4+ T-cell depletion may have deteriorating effects on the survival of glioblastoma patients.
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Mirouze, J. "Introduction to the 1st International Diamicron® Symposium in Canada". Diabetes Research and Clinical Practice 14 (enero de 1991): S1—S2. http://dx.doi.org/10.1016/0168-8227(91)90001-t.
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Klyuchnikov, Evgeny, Nicolaus Kröger, Francis Ayuketang, Claudia Langebrake, Christine Wolschke, Heinrich Lellek, Axel R. Zander y Ulrike Bacher. "Application of Nelarabine for Refractory or Relapsed T-Lymphatic Neoplasms In Adults Before Allogeneic Stem Cell Transplantation." Blood 116, n.º 21 (19 de noviembre de 2010): 3496. http://dx.doi.org/10.1182/blood.v116.21.3496.3496.
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Abstract Abstract 3496 Introduction: Allogeneic hematopoietic stem cell transplantation (allogeneic HSCT) has found entrance into treatment of patients (patients) with poor-risk T-cell malignancies, but post-transplant relapse rates of ~30% were reported (Marks et al. Blood 2009). Improvement of the pre-transplant remission status in relapsed/refractory disease might lead to better outcomes. Nelarabine - a novel purine antimetabolite - has been approved by the FDA in 2005 as salvage approach for patients with T-cell malignancies, but data on pre-transplant use are limited (Goekbuget et al. ASH Annual Meeting 2005). Patients/Methods: Aiming to estimate its clinical applicability and efficacy in the pre-transplant period, we evaluated its use in 8 patients (5 males, 3 females; 22–56 years) with precursor/mature T-cell neoplasms who had failed to ≥2 previous conventional/intensified chemotherapy regimens (including a history of autologous/allogeneic HSCT in 2 patients) and were consequently proceeded to allogeneic HSCT (in 6 cases the 1st, in 2 cases the 2nd allogeneic HSCT). Five had T-ALL (1 pre-T-, 3 cortical, 1 mature), 3 had mature T-cell lymphomas (angioimmunoblastic lymphoma, n=1; peripheral T-cell lymphoma not otherwise specified, n=2), all with bone marrow involvement. Patients entered conventional chemotherapy in 6 cases at the 1st manifestation of disease, in 2 cases at the 1st relapse. Following conventional chemotherapy, 5 patients developed an early relapse, while 2 patients were refractory to treatment; one patient was minimal residual disease (MRD) positive as assessed by multiparameter flow cytometry. Therefore, all 8 patients were offered an allogeneic HSCT (1st allogeneic HSCT: n=6; 2nd allogeneic HSCT: n=2) with pre-treatment with nelarabine. The median interval from the last chemotherapy to 1st nelarabine administration was 8 weeks (range, 1– 252 weeks). Nelarabine (1,500 mg/m2 i.v.) was administrated on days 1, 3, and 5 at a median of 11 weeks (range, 2–53 weeks) before allogeneic HSCT. Three patients received a 2nd cycle of nelarabine after a median of 4 weeks (range, 2–9 weeks) from the 1st. Six patients had unrelated (HLA-match, n=4; mismatch, n=2) and 2 patients matched related donors. Most patients received myeloablative conditioning (TBI, 12 Gy; cyclophosphamide 120 mg/kg; n=3; treosulfan 36 g/m2; etoposide 30 mg/kg; cyclophosphamide 120 mg/kg; n=4). In the 8th patient who had already received 2 courses of nelarabine, a 3rd nelarabine application was incorporated as pre-phase into reduced-intensity conditioning (nelarabine 2 × 1,500 mg/m2; fludarabine 90 mg/m2; TBI 8 Gy). Results: i) Pre-transplant application of nelarabine: Immediate neurotoxicity was observed in 1 patient (grand mal seizure day +3 after the last nelarabine administration). Grade II hematotoxicity was observed in 3/8 patients. There were no treatment-related deaths. Seven of 8 patients showed response to nelarabine (86%; CR, n=5; PR, n=2) after a median of 4 weeks (1 – 35 days) from the 1st cycle. One patient had stable disease (SD). ii) Peri-/post-transplant period: there were no uncommon adverse events. After HSCT, prolonged leukocytopenia (WBC <1,000/μL >20 days) and thrombocytopenia (thrombocytes <20,000/ μL >30 days) were observed in 3 and 5 patients, respectively. At the 1st post-transplant bone marrow control, 3 patients with residual disease (PR or SD) prior to allogeneic HSCT achieved CR, and all other patients maintained CR. Acute (grade II) and chronic GvHD developed in 2/8 (25%) and in 2/6 (33%) patients, respectively; there was no case of grade III-IV acute GvHD. At a median follow up of 9 months (range, 1–24), 3 patients had died (38%; relapse, n=1, t-AML, n=1; transplant-related toxicity, n=1). All 5 patients being alive were in CR; 4 patients required no further treatment, and one patient received donor lymphocyte infusions (DLIs) due to mixed chimerism. Conclusions: Nelarabine improves pre-transplant remission in patients with relapsed/refractory T-cell neoplasms and seems to be well tolerated immediately before allogeneic HSCT even in heavily pre-treated patients. The compound might be used as pre-phase or be incorporated into conditioning for allogeneic HSCT which should be further evaluated. Disclosures: No relevant conflicts of interest to declare.
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Evdokimov, М. G., V. S. Yusov y I. V. Pakhotina. "Correlation between productivity and grain quality of spring durum wheat and meteorological factors in the southern forest-steppe of the Western Siberia". Grain Economy of Russia, n.º 5 (30 de octubre de 2020): 26–31. http://dx.doi.org/10.31367/2079-8725-2020-71-5-26-31.
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The purpose of the current study was to identify the effect of meteorological factors on productivity and grain quality indicators of spring durum wheat in the conditions of Western Siberia. The research was carried out in the FSBSI “Omsk Agricultural Research Center” in 1981-2019. The object of the study was the durum spring wheat variety ‘Almaz', which was tested in the nurseries of the Competitive Variety Testing according to such traits as productivity, nature weight, hardness of grain, protein and gluten percentage, IDK, pasta color. The average productivity through the years of study was 2.51 t/ha, the differences between indicators in the unfavorable (1.54 t/ha) and favorable (3.48 t/ha) years were 1.94 t/ha. The grain nature weight in the years with good humidity was on 22g/l larger than in the arid years, the hardness of grain was on 5% larger. The protein and gluten percentage, the pasta color value was larger in the unfavorable climatic years (on 1.60%, 4.3%, 0.2 points, respectively), compared with favorable ones. There has been found that the productivity was positively associated with the precipitation in May and the 1st decade of July, relative humidity in May and June; there was established a negative correlation with air temperature in June. The nature weight of grain had a negative dependence on precipitation (1st and 2nd decades) and relative humidity in August for all decades. The hardness of grain was positively affected by temperature in May and precipitation in July (1st decade). The protein percentage in grain was negatively affected with precipitation and relative air humidity in May, June and July (1st and 3rd decades). Average daily temperatures in May and July had a positive effect on the protein percentage in grain. The gluten percentage had a positive correlation with the temperature in May and in the third decade of July. A negative dependence of this indicator was established with precipitation in May, June and the 3rd decade of July, with the relative humidity in May, June, July (1st and 3rd decades), August (3rd decade). The pasta color was negatively dependent on precipitation and relative humidity in July (3rd decade) and August (1-2nd decades).
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Nurani, Irma Dian. "Gonadotropine Releasing Hormone (GnRH) Receptor Profile from Cow’s Hypothalamus". Jurnal Sain Veteriner 38, n.º 2 (1 de agosto de 2020): 188. http://dx.doi.org/10.22146/jsv.51882.
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Gonadotropine Releasing Hormone (GnRH) is one of the recommended hormones to overcome ovulation problems and it can increase pregnancy rate so that it is used in government programs to increase cattle population in Indonesia, although the results are not yet optimal. The purpose of this study is to compare the composition of bovine GnRH receptor nucleotides with the GenBank reference so that the level of genetic diversity of bovine receptors in Indonesia is known. PCR product sequencing using Promoter F and Exon 1 R primers were further aligned with the reference sequences of Bos Taurus GnRHR mRNA GenBank using the MEGA X program. The results of the analysis found the presence of Single Nucleotide Polymorphism (SNP) in the coding region of 1st cow position 38(A> T), 261(C > T), 342(C >T), 411(C >T) and 495(C > T) and 2nd cow positions 261(C >T). Changes in amino acids were also detected in 1st cow position 13 (H> L). The presence of SNP was found to indicate genomic variation between individuals at cattle receptors in Indonesia.
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Kewalramani, Tarun, Steve Horwitz, Andrew D. Zelenetz, Stephen D. Nimer y Craig H. Moskowitz. "Late Relapses Characterize Autologous Transplantation (ASCT) in First Complete Remission (CR) for Peripheral T-Cell Lymphoma (PTCL)." Blood 110, n.º 11 (16 de noviembre de 2007): 5110. http://dx.doi.org/10.1182/blood.v110.11.5110.5110.
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With the exception of ALK-positive anaplastic large cell lymphoma (ALCL), standard-dose chemotherapy is curative in a minority of patients (pts) with PTCL, and most pts have progressive disease less than 2 years from completing treatment. Several studies suggest that ASCT in 1st CR significantly improves the short-term outcome of pts with PTCL, but its long-term efficacy is not known. To address this, we assessed the outcome of sequential patients who underwent ASCT in 1st CR (n=15). Histologic subtypes were PTCL, unspecified, in 6 pts, angioimmunoblastic T-cell lymphoma in 5 pts, ALK-negative ALCL in 3 pts and hepatosplenic gamma delta T-cell lymphoma in 1 pt. Induction chemotherapy was CHOP (n=2) or CHOP-ICE hybrid (n=12) in 93% of pts. The age-adjusted IPI (AAIPI) was 2–3 in 9 of 14 assessable patients (64%), and 11 pts (73%) had stage III–IV disease. The conditioning regimen consisted of BEAM or CBV in 10 pts and TBI/Cy/VP-16 in 5 pts. All patients received peripheral blood progenitor cells for hematopoietic support. The median follow-up of all patients is 24 months (range 4.5–70). Five pts (33%) have progressed, with a median time to progression of 50 months (range 10–70). Four of the 5 pts who progressed did so more than 2 years from ASCT; they comprise 57% of patients with more than 2-years of follow-up. Four of 5 patients with progressive disease have died, with a median time from progression to death of 1 month (0.6–14.6). In this small series the AAIPI was not predictive of PFS or OS. While our results confirm the that ASCT in 1st CR significantly delays the time to progression, they suggest that it may not be curative in the majority of patients. If confirmed in ongoing larger prospective studies, this observation warrants trials of post-ASCT maintenance treatment and, for younger patients, trials of allogeneic transplantation in 1st CR or sequential ASCT followed by allogeneic transplantation. Figure Figure
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Small, Eric Jay, Raymond S. Lance, Charles H. Redfern, Frederick E. Millard, Thomas A. Gardner, Lawrence Ivan Karsh, Nancy Ann Dawson et al. "A randomized phase II trial of sipuleucel-T with concurrent or sequential abiraterone acetate (AA) plus prednisone (P) in metastatic castrate-resistant prostate cancer (mCRPC)." Journal of Clinical Oncology 31, n.º 15_suppl (20 de mayo de 2013): 5047. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.5047.
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5047^ Background: Sipuleucel-T and AA + P are FDA-approved for asymptomatic/minimally symptomatic mCRPC. Suppression of the androgen axis can be immunostimulatory and AA suppresses circulating androgen levels; AA plus sipuleucel-T may therefore be synergistic. However P used with AA, which may be immunosuppressive, has not been studied with concurrent sipuleucelET and could impair sipuleucel-T production and/or immunologic response. P11-3 (NCT01487863) is the 1st study to evaluate the combination of sipuleucel-T and AA + P Methods: Patients (pts) with asymptomatic/minimally symptomatic mCRPC were randomized (1:1) to sipuleucel-T (3 infusions at approx 2-wk intervals) with up to 26 wks of AA + P (AA 1000mg QD + P 5mg BID) starting 1 day after the 1st sipuleucel-T infusion (concurrent, arm A) or at 10 wks following the 1st sipuleucel-T infusion (sequential, arm B). Endpoints included the effect of AA + P on product (sipuleucel-T) characteristics eg antigen presenting cell (APC) activation, measured as CD54 upregulation (primary endpoint), APC (measured as CD54+ cells) and total nucleated cell (TNC) counts, as well as safety and immunologic responses. Results: 31 pts in arm A and 32 pts in arm B completed sipuleucel-T treatment by the interim analysis (Nov 2012). Baseline characteristics were similar in the 2 arms. 60/63 pts received all 3 infusions of sipuleucel-T. No significant differences in median cumulative APC activation, APC count or TNC count were seen between the arms. Increased CD54 upregulation with the 2nd and 3rd treatments were indicative of a prime boost effect in both arms. Similar profiles of antigen-specific humoral and cellular immune responses were generated with no difference in magnitude of response between the arms (p>0.05). The incidence of adverse events (AEs) and serious AEs was similar in both arms. Conclusions: These data suggest sipuleucel-T can be successfully manufactured during concurrent AA + P. Product potency and prime boost effect were similar to sipuleucel-T alone. Immune responses and AEs were similar in both arms. It is not known if sipuleucel-T will provide similar efficacy with concurrent or sequential AA + P. Clinical trial information: NCT01487863.
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Chavez, Julio C., Caron A. Jacobson, Alison Sehgal, Sattva Swarup Neelapu, David G. Maloney, Gilles A. Salles, Basem M. William et al. "Updated outcomes with axicabtagene ciloleucel (axi-cel) retreatment (reTx) in patients (pts) with relapsed/refractory (R/R) indolent non-Hodgkin lymphoma (iNHL) in ZUMA-5." Journal of Clinical Oncology 39, n.º 15_suppl (20 de mayo de 2021): 7548. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.7548.
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7548 Background: ZUMA-5 is a Phase 2 study of axi-cel anti-CD19 CAR T-cell therapy in pts with R/R iNHL (follicular lymphoma [FL]; marginal zone lymphoma [MZL]). In the primary analysis, 11 pts (9 FL; 2 MZL) were retreated with axi-cel, achieving an overall response rate (ORR) of 100% (91% complete response [CR] rate) at a median follow-up of 2.3 mo post-reTx, with no Grade ≥3 cytokine release syndrome (CRS) or neurologic events (NEs; Chavez et al. ASH 2020. #2036). Here, we report updated clinical and translational outcomes with longer follow-up in pts retreated with axi-cel in ZUMA-5. Methods: Eligible pts with FL or MZL had R/R disease after ≥2 lines of therapy. Pts were considered for reTx if they progressed after a response at mo 3, had no evidence of CD19-negative relapse in biopsy, had no axi-cel neutralizing antibodies, and had no Grade 4 CRS or NEs with 1st Tx. Retreatment was per investigator discretion. At both Txs, pts received axi-cel (2×106 CAR T cells/kg) after conditioning chemotherapy. Results: As of 9/14/2020, 13 pts with iNHL (11 FL; 2 MZL) received axi-cel reTx, with 2 pts retreated after the primary analysis. Before their 1st Tx, pts had median 4 prior lines of therapy; 85% had stage 3–4 disease; 82% had FLIPI of ≥3; 46% were POD24; 77% had refractory disease. Among the 13 retreated pts, 85% had a CR to 1st Tx. Median 1st duration of response (DOR) was 8.2 mo. Detectable CD19 was confirmed in all evaluable biopsies from retreated pts at relapse, and median time from 1st Tx to reTx was 10.6 mo. Following reTx, the ORR was 100% (77% CR rate). After a median follow-up of 11.4 mo, the median DOR had not yet been reached; 46% of retreated pts had ongoing responses at data cutoff. At 1st Tx, CRS occurred in 9 pts (5 Grade 1, 4 Grade 2); NEs occurred in 5 (3 Grade 1, 1 Grade 2, 1 Grade 3). At reTx, CRS occurred in 8 pts (6 Grade 1, 2 Grade 2); NEs occurred in 4 (3 Grade 1, 1 Grade 2). Median peak levels of biomarkers typically associated with severe CRS and NEs were similar at reTx and 1st Tx (IL-6, 7.7 vs 5.7 pg/mL; IL-2, 1.8 vs 0.9 pg/mL; IFN-γ, 62.9 vs 64.2 pg/mL). In the 11 retreated pts with FL, tumor burden (median sum of product diameters [SPD]) was lower before reTx vs 1st Tx (1416 vs 4770 mm2). Engraftment index (CAR T-cell expansion relative to SPD) is an indirect proxy for effector:target ratio and a key covariate of response to axi-cel (Locke et al. Blood Adv. 2020). Though median peak CAR T-cell levels appeared lower at reTx vs 1st Tx (5.2 vs 14.3 CAR+ cells/µL blood), engraftment index was similar (0.003 vs 0.005 cells/µL×mm2). Conclusions: Axi-cel reTx achieved deep and durable responses, with an acceptable safety profile. Tumor CD19 positivity was maintained at relapse, and engraftment index was similar at both Txs, comparing favorably to previous reports in aggressive lymphomas (Locke et al. ASCO 2020. #8012). These data suggest axi-cel reTx is a promising option for pts with R/R iNHL. Clinical trial information: NCT03105336.
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Aprilian, Malisa, Muhali Muhali y Citra Ayu Dewi. "Pengaruh Model POGIL (Process Oriented Guided Inquiry Learning) Terhadap Keterampilan Berpikir Kreatif dan Pemahaman Konsep Siswa Pada Materi Redoks". Hydrogen: Jurnal Kependidikan Kimia 6, n.º 2 (23 de enero de 2019): 114. http://dx.doi.org/10.33394/hjkk.v6i2.1605.
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This study aims to determine the effect of POGIL to creative thinking skilland conceptual understanding of students at senior high school. This researchform of quasi experimental was carried out by postest-only control groupdesign. Research conducted in SMAN1 Montong Gading using sample whichdetermined by saturated sampling technique, 24 number of XA class studentsas experiment class, and 24 number of XB class students as control class.Creative thinking skills data was collected by observation sheets andconceptual understanding data by reasoning multiple choices test. The resultsshowed that the average creative thinking skill of experimental class at the 1st,2nd, and 3rdmeeting was 64.388, 72.656, and 79.752.The mean of creativethinking skill of the control class at the 1st, 2nd, and 3rdmeeting was 59.765,67.447, and 73.476.The hypothesis test result of creative thinking skill datausing independent sample t-test it is known that significance value of t-countwas 0.040 < 0.05, and conceptual understaning data by paired sample t-test itis known that significance value of t-count was 0.000 < 0.05. So that, there isinfluence of POGIL model to student creative thinking skill and conceptualunderstanding.
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Chelidze, V. "Written Sources from Ancient Albanian-Georgian Communications (Sagdukht - Princess Rani and Queen of Kartli)". Язык и текст 7, n.º 3 (2020): 89–99. http://dx.doi.org/10.17759/langt.2020070309.
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National-cultural and religious disappearance of the Christian countries of the Caucasus (Albania, Iberia, Armenia) from the V century was threatened by Persia. "Kartlis Tskhovreba" (History of Georgia) tells in detail about these acute and dramatic historical events. Historical writings from a later period show one feature of this region. The references to Rani (Aran) as Persia ("Mirian... called from Persia his relative, a descendant of kings, named Peroz") and the inhabitants of this country as Persians ("in Ran, wherever the Persians fought") should not be taken literally. In Georgian historical works, the terms "Persia" and" Persian " in addition to Persia and Persians also meant countries and peoples of the Near and Middle East-Arabs, Turks, and others: "Sultan Arfasaran came out, king of P e R s I I" (Leonti Mroveli, Life of kings); "P e R s I d s K I e s u l t a n s, far and near" ("Chronicle of the times of lash Giorgi", life of king Giorgi); "the Georgians entered the castle, and there was a strong battle, and p e R s s B a g d a d a were defeated" (Chronicle of the century). This situation is due to the fact that the entire territory to the East of the Caucasus for centuries belonged to and was ruled by the Persian Empire of the Achaemenid, Arshakid and Sasanian eras (much later the Arab Caliphate and then the Turkish Sultanate appeared on the historical scene). In Georgian historical texts, in particular in the chronicle "Life of the kings" by Leonti Mroveli, a logical geographical description is given about this – "Persians from the East of the sun". According to Georgian historical data, these peoples also include Albanians who lived to the East of the Georgians. One of the most notable historical events is an extensive episode of romantic love in the life of an Albanian Princess, the daughter of the ruler of Rani (Aran) Barzaboda and a thorough historical account of the dramatic state activities of the Queen of Kartli (Iberia), mother of the great Georgian king Vakhtang Gorgasal-S a g d u x t.