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Tesis sobre el tema "Oxidative Aging"

Autor: Grafiati
Publicado: 4 de junio de 2021
Última modificación: 26 de julio de 2025

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1

AragÃo, Theresa Christine Filgueiras Russo. "Oxidative damages and ageing bean seeds Caupi." Universidade Federal do CearÃ, 2007. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=17178.

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FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgico<br>The present study was carried out to elucidate the relationship between seed ageing and oxidative damage in two cowpea (Vigna unguiculata (L.) Walp.) cultivars, namely PitiÃba and PÃrola.The seeds were articially aged at 45 ÂC and 99% relative humidity until 72 h and daily harvested. Seed germination, electrolyte leakage, lipid and protein oxidation were evaluated. Moreover, changes in superoxide dismutase (SOD), ascorbate peroxidase (APX) and catalase (CAT) activity as their isoform pattern and CAT an
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2

Garg, Richa [Verfasser], and Elmar [Akademischer Betreuer] Heinzle. "Oxidative stress induced alterations during aging : quantifying the metabolic changes associated with aging and oxidative stress / Richa Garg ; Betreuer: Elmar Heinzle." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2017. http://d-nb.info/1140043331/34.

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Jervis, Kathryn. "Oxidative stress and aging of the male reproductive tract." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84264.

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The global demographic shift towards population aging will result in a dramatic increase in the numbers of elderly in the population. In order to cope with these changing demographics, it is imperative that we better understand aging and age-related pathologies. The reproductive tract provides an excellent system in which to study aging in that it is affected by aging, without compromising the overall health of the individual. In the Brown Norway rat model, the male reproductive tract (testis and epididymis) shows numerous signs of aging when other systems remain relatively unaffected b
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Pournoman, Sara. "Oxidative Aging of Binders with High Recycled Asphalt Materials." Thesis, University of Nevada, Reno, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10282654.

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<p> The objectives of this research effort focused on the oxidative aging of binders with high recycled asphalt materials. A coordinated program of forced-draft oven aging experiments was conducted on eleven sorts of binder blends including three different types of base binders from TX, NH, and NV, two different types of recycled material (RAP/RAS), and two different types of recycling agents (RA). Implementing the Fourier-Transform Infrared Spectroscopy (FT-IR) and Dynamic Shear Rheometer (DSR) isothermal frequency sweep tests, the oxidation kinetics and rheological performance were determine
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Tsirklin, Liana. "Role of NADPH Oxidase in Oxidative Stress and Aging." Thesis, The University of Arizona, 2012. http://hdl.handle.net/10150/245082.

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As people age, their preferential adipose tissue stores tend to shift from subcutaneous to visceral, which could lead to diabetes, since visceral adipose tissue is insulin resistant. One of the proposed mechanisms for this shift is due to elevated levels of oxidative stress in adipose tissue cells due to aging, as a result of increased levels of NADPH oxidase (NOX). The goal of these experiments is to determine the existence and significance of this potential correlation. Visceral, subcutaneous, and stromal vascular adipose tissue samples from 18 week and 20 month old mice were probed for p47p
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Li, Ying Bo. "Anti-oxidative and pro-oxidative effects of curcuminoids on cellular senescence in aging and cancer." Thesis, University of Macau, 2011. http://umaclib3.umac.mo/record=b2492795.

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Lemon, Jennifer Rollo C. David. "Oxidative stress and aging processes in transgenic growth hormone mice." *McMaster only, 2005.

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Aragão, Theresa Christine Filgueiras Russo. "Danos oxidativos e o envelhecimento de sementes de feijão Caupi." reponame:Repositório Institucional da UFC, 2007. http://www.repositorio.ufc.br/handle/riufc/18805.

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ARAGÃO, Theresa Christine Filgueiras Russo. Danos oxidativos e o envelhecimento de sementes de feijão Caupi. 2007. 143 f. Tese (Doutorado em bioquímica)- Universidade Federal do Ceará, Fortaleza-CE, 2007.<br>Submitted by Elineudson Ribeiro (elineudsonr@gmail.com) on 2016-07-28T16:01:17Z No. of bitstreams: 1 2007_tese_tcfraragao.pdf: 2017147 bytes, checksum: bb55db2b9161858e82e3c40141a1cb97 (MD5)<br>Approved for entry into archive by José Jairo Viana de Sousa (jairo@ufc.br) on 2016-08-02T14:43:17Z (GMT) No. of bitstreams: 1 2007_tese_tcfraragao.pdf: 2017147 bytes, checksum: bb55db2b9161858e82e3
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Luciano, Mateo Fedra Nicaury. "The role of chemokine (c-c motif) ligand 2 in inflammation, oxidative stress, aging and metabolism." Doctoral thesis, Universitat Rovira i Virgili, 2019. http://hdl.handle.net/10803/667564.

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El metabolisme i el sistema immunològic estan estretament relacionats i les seves interaccions juguen un paper important en l'homeòstasi sistèmica. L'activació, proliferació, diferenciació i polarització de les cèl·lules immunitàries representen un important estrès metabòlic, que pot comprometre el metabolisme cel·lular, l'homeòstasi i les necessitats energètiques. Aquestes condicions poden promoure l'estrès metabòlic crònic i les anomalies metabòliques en patologies no immunes. No obstant això, encara no queda clar com aquests canvis en el perfil immunològic afecten el metabolisme sistèmic. C
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10

Shao, Changxing. "OXIDATIVE STRESS AND MITOCHONDRIAL DYSFUNCTION IN TRAUMATIC BRAIN INJURY IN AGING." UKnowledge, 2007. http://uknowledge.uky.edu/gradschool_diss/533.

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Traumatic brain injury (TBI) is a prominent disease in developed countries, and age is an important factor in functional outcome. Although aged patients typically show diminished recovery compared to young patients, and have higher mortality and morbidity following TBI, the mechanism is not well understood. To date, there is no effective therapeutic for TBI. Previous studies indicate a secondary injury in TBI begins immediately after impact, and is likely the major contribution to delayed neuron dysfunction and loss. Studies also suggest mitochondrial dysfunction and increased free radical spe
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11

Morian, Nathan E. "Influence of mixture characteristics on the oxidative aging of asphalt binders." Thesis, University of Nevada, Reno, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3626103.

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<p> The objective of this research effort focused on the evaluation of asphalt mixtures with respect to thermal cracking. Preliminary investigations soon indicated that a fundamental evaluation of thermal cracking was highly dependent upon the more complicated understanding of asphalt binder oxidation. The oxidation of asphalt binders within an asphalt mixture were understood to potentially be influenced by the mixture characteristics (i.e. air void levels, binder content, etc.) and aggregate properties (i.e. aggregate absorption, gradation, etc.). Therefore, this study was conducted in ord
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12

Chen, Ying. "Relationship of Glutathione Deficiency to Oxidative Stress-Related Disease and Aging." University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1172086646.

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Lim, Christopher Y. (Christopher Yung-Ta). "Laboratory studies of the multiday oxidative aging of atmospheric organic aerosol." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/121882.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Civil and Environmental Engineering, 2019<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Fine particulate matter (PM, or "aerosol") in the atmosphere affects the Earth's radiative balance and is one of the most important risk factors leading to premature mortality worldwide. Thus, understanding the processes that control the loading and chemical composition of PM in the atmosphere is key to understanding air quality and climate. However, the chemistry of organic aerosol (OA), which compris
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PRIORI, ERICA CECILIA. "Oxidative stress and neuroinflammation effects in hippocampal development, aging, and disease." Doctoral thesis, Università degli studi di Pavia, 2021. http://hdl.handle.net/11571/1431654.

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This PhD thesis aims to evaluate oxidative stress and inflammation pathways considering three pathological models such as Prolidase Deficiency, Physiological Aging and Anorexia Nervosa. Furthermore, preliminary experiments were performed to better understand the involvement of different cell death pathways i.e. apoptosis, autophagy and mitophagy. Prolidase deficiency (PD) is a rare genetic disorder caused by a mutation in the PEPD gene that codes for the prolidase enzyme. This enzyme can selectively cut proline dimers present at the carboxy-terminal end of a polypeptide and participates in the
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Davies, Stefan M. K., and n/a. "Oxidative damage to mitochondria on ageing in rats." University of Otago. Department of Biochemistry, 2007. http://adt.otago.ac.nz./public/adt-NZDU20070403.111245.

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Ageing is a complex phenomenon, characterised by progressive loss of function, decreasing resistance to age-associated pathologies and stress, and increasing rates of mortality. The Free Radical Theory of Ageing implicates reactive oxygen and nitrogen species (ROS/RNS) generation as being integral to the ageing process, subjecting the organism to oxidative stress. Oxidative damage to biomolecules is suggested to be causative in the formation of ageing-associated phenotypes, dysregulation and dysfunction. Mitochondria are responsible for the production of the majority of ROS/RNS through norma
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16

Weir, Cameron 1981. "Aging and oxidative stress in epididymal spermatozoa of the Brown Norway rat." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101806.

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Aging is characterized by an imbalance in cellular redox status due to an increase in the production of reactive oxygen species (ROS) and a decreased activity of the cellular antioxidant defenses. Spermatozoa are highly susceptible to oxidative stress and hence this mechanism likely plays a causal role in the deficiencies associated with aging and male reproduction. The goal of this study was to determine the effect of age on antioxidant enzymatic activity, ROS production, and lipid peroxidation in spermatozoa along the epididymis of the Brown Norway rat. Aging significantly decreased glutathi
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17

Estery, Carmen M. "Mitochondrial uncoupling and remodelling during caloric restriction: Implications for oxidative stress and aging." Thesis, University of Ottawa (Canada), 2009. http://hdl.handle.net/10393/28479.

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The 'uncoupling to survive' theory suggests that mitochondrial uncoupling protects cells from reactive oxygen species (ROS), thereby slowing aging. Caloric restriction (CR) mitigates aging; mechanisms may involve mitochondrial remodelling such that ROS production is decreased. It is unclear how uncoupling protein 3 (UCP3) in skeletal muscle is involved. Objective: To characterize effects of short-term 40% CR in wildtype (Wt) and UCP3 transgenic (UCP3 Tg) mice that possess uncoupled mitochondria. Hypothesis: In an uncoupled system, CR provides no further ROS protection. Approaches: Muscle mitoc
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Yi, Dong-Hui Chemistry Faculty of Science UNSW. "The Study of Biomarkers of Protein Oxidative Damage and Aging by Mass Spectrometry." Awarded by:University of New South Wales. School of Chemistry, 1999. http://handle.unsw.edu.au/1959.4/17636.

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The physiologically important free radicals, nitrogen monoxide and superoxide, can combine to form the reactive intermediate peroxynitrite. Peroxynitrite can react with proteins and their constituent amino acids, such as tyrosine, resulting in protein peroxidation, oxidation and nitration. The nitration of proteins, assessed by the analysis of 3-nitrotyrosine, is a proposed index of pathophysiological activity of peroxynitrite. The aim of the work was to investigate the reaction products between peroxynitrite and protein, develop an assay for 3-nitrotyrosine and measure its levels in biologi
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Asano, Shinichi. "Aging influences multiple indices of oxidative stress in the heart of the Fischer 344/NNia x Brown Norway/BiNia rat." Huntington, WV : [Marshall University Libraries], 2007. http://www.marshall.edu/etd/descript.asp?ref=735.

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Theses (M.S.)--Marshall University, 2007.<br>Title from document title page. Includes abstract. Includes vitae. Document formatted into pages: contains ix, 81 pages including illustrations. Bibliography: p. 69-77.
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Poon, Hung Fai. "REDOX PROTEOMICS IDENTIFICATION OF OXIDATIVELY MODIFIED PROTEINS AND THEIR PHARMACOLOGICAL MODULATION: INSIGHT INTO OXIDATIVE STRESS IN BRAIN AGING, AGE-RELATED COGNITIVE IMPAIRMENT." UKnowledge, 2005. http://uknowledge.uky.edu/gradschool_diss/287.

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The studies presented in this work were completed with the goal ofgaining greater insight into the roles of protein oxidation in brain aging and age-relatedcognitive impairment. Aging is associated with the impairment of physiological systemssuch as the central nervous system (CNS), homeostatic system, immune system, etc.Functional impairments of the CNS is associated with increased susceptibility to developmany neurodegenerative diseases such as Alzheimer's diseases (AD), Parkinson's disease(PD), and amyotrophic lateral sclerosis (ALS). One of the most noticeable functionalimpairments of the
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21

Hosseini, Seyed Mohsen. "Role of oxidative and energy metabolism in skin aging and UV-B induced carcinogenesis." Thesis, Bordeaux, 2015. http://www.theses.fr/2015BORD0117/document.

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L’objectif de notre étude était de montrer le rôle du métabolisme oxydatif et énergétique au cours du vieillissement cutané et dans les cancers cutanés UVB-induits. Dans une première partie, nous avons cherché à établir un lien entre l'instabilité génétique, la production de ROS et l’altération métabolique dans le processus de vieillissement. Les résultats obtenus sur le modèle de souris XPC KO ont démontré qu’un excès de stress oxydatif dû à une sur activation du NOX1, couplé à des altérations métaboliques, jouaient un rôle prépondérant dans le vieillissement prématuré. L’application topique
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22

MOTTA, SILVIA. "THE INFLUENCE OF SOME ANTIOXIDANT MOLECULES AND OXYGEN LEVELS ON OXIDATIVE AGING OF WINES." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/239329.

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L'ossigeno ha un ruolo fondamentale durante tutto il processo di vinificazione: l’apporto di ossigeno, prima, durante e dopo la fermentazione alcolica può influenzare le caratteristiche del vino e la sua evoluzione sia in modo positivo che negativo. In generale i vini rossi possono beneficiare di un certo grado di ossidazione per ridurre l'astringenza e stabilizzare il colore, mentre i vini bianchi di solito sono danneggiati dall’ossigeno. Per favorire i benefici di esposizione all'ossigeno ed evitare i rischi di deterioramento, è necessario capire a fondo i meccanismi di ossidazione nel v
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Guzel, Aylin. "Photo-oxidative Degradation Of Abs Copolymer." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/12610895/index.pdf.

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ABSTRACT PHOTO-OXIDATIVE DEGRADATION OF ABS COPOLYMER G&uuml<br>zel, Aylin M.S., Department of Polymer Science and Technology Supervisor: Prof. Dr. Teoman Tin&ccedil<br>er Co-Supervisor: Prof. Dr. Cevdet Kaynak September 2009, 55 pages Acrylonitrile-butadiene-styrene (ABS) polymer is one of the most popular copolymer having an elastomeric butadiene phase dispersed in rigid amorphous styrene and semi-crystalline acrylonitrile. Due to double bonds in the polybutadiene phase, ABS copolymers are very sensitive to photo-oxidative degradation. Photo-oxidation of butadiene rubber ph
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24

Opii, Wycliffe Omondi. "OXIDATIVE STRESS AND REDOX PROTEOMICS STUDIES IN MODELS OF NEURODEGENERATIVE DISORDERS: I. THE CANINE MODEL OF HUMAN AGING; II. INSIGHTS INTO SUCCESSFUL AGING; AND III. TRAUMATIC BRAIN INJURY." UKnowledge, 2006. http://uknowledge.uky.edu/gradschool_diss/299.

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The studies presented in this dissertation were conducted with the objective ofgaining greater understanding into the mechanisms of successful aging, the role ofmitochondria dysfunction in traumatic brain injury, and also on the mechanisms ofimproved learning and cognitive function in the aging.Aging is usually characterized by impairments in physiological functionsincreasing its susceptibility to dementia and neurodegenerative disorders. In thisdissertation, the mechanisms of dementia-free aging were investigated. The use of anantioxidant fortified diet and a program of behavioral enrichment
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Lopez-Cruzan, MariaLuisa (Marisa). "Role of caspase-2 in oxidative stress induced apoptosis : possible importance in aging : a dissertation /." San Antonio : UTHSC, 2007. http://proquest.umi.com/pqdweb?did=1397904881&sid=1&Fmt=2&clientId=70986&RQT=309&VName=PQD.

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Poon, Hung Fai. "Redox proteomics identification of oxidatively modified proteins and their pharmacological modulation insights into oxidative stress in brain aging, mild cognitive impairment /." Lexington, Ky. : [University of Kentucky Libraries], 2005. http://lib.uky.edu/ETD/ukychem2005d00344/FaiPoon.pdf.

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Thesis (Ph. D.)--University of Kentucky, 2005.<br>Title from document title page (viewed on January 6, 2006). Document formatted into pages; contains: xviii, 554 p. : ill. Includes abstract and vita. Includes bibliographical references (p. 434-550).
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Furtado, Filho Orlando Vieira. "Efeitos crônicos não-térmicos das ondas eletromagnéticas não-ionizantes sobre o córtex cerebral e o fígado de ratos com diferentes idades." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2012. http://hdl.handle.net/10183/69713.

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O desenvolvimento tecnológico aumentou a exposição dos organismos às ondas eletromagnéticas (OEM). Dependendo das condições de exposição, este agente físico pode causar mudanças comportamentais, fisiológicas, celulares e moleculares. Neste nível de organização biológico, a literatura científica vem relacionando as OEM com o metabolismo das espécies reativas de oxigênio (ERO). Estas podem causar danos oxidativos a ácidos nucleicos, lipídios e proteínas. Entretanto, para se defender destas lesões, os sistemas biológicos apresentam defesas antioxidantes. O desequilíbrio entre oxidantes e antioxid
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Fukui, Hirokazu. "Mitochondrial Involvement in the Accumulation of Misfolded Proteins in Neurodegenerative Diseases." Scholarly Repository, 2008. http://scholarlyrepository.miami.edu/oa_dissertations/41.

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Mitochondrial respiratory chain deficiency and increased oxidative stress have been closely associated with major age-associated neurodegenerative diseases. I hypothesized that mitochondrial oxidative phosphorylation defects or elevated oxidative stress, which could arise in a stochastic manner during our normal aging process, might modulate the formation of protein aggregates or production of misfolded proteins, contributing to the initiation of these diseases. To test this hypothesis, we (i) have developed and characterized mouse and cellular models of Alzheimer's and Huntington's diseases
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Domínguez, González Mayelín. "Daño oxidativo y regulación redox en el envejecimiento cerebral: vulnerabilidad regional." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/565614.

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El presente trabajo exploró el proceso de envejecimiento cerebral humano considerando la vulnerabilidad regional específica en cuanto a eventos de daño oxidativo, respuesta antioxidante, metabolismo energético y moléculas implicadas en la inflamación. Se emplearon muestras de tejido post mortem de 12 regiones cerebrales (corteza frontal, corteza parietal, giro cingulado, corteza temporal, corteza entorrinal, hipocampo, tálamo, caudado, putamen, corteza visual, sustancia nigra y vermis) provenientes de 18 sujetos sanos de mediana y avanzada edad (grupos de edad). Mediante proteómica redox se id
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Vinayak, Anubhav. "Role of Oxidative Stress in Diabetes Mellitus." Youngstown State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1526905602340959.

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Son, Jyung Mean. "Age-associated metabolic reprogramming, oxidative stress response, and cancer progression." Diss., University of Iowa, 2017. https://ir.uiowa.edu/etd/5856.

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Replicative and chronological lifespan are two different modes of cellular aging. Chronological lifespan is defined as the duration during which quiescent normal cells retain their capacity to re-enter the proliferative cycle. This study investigates whether changes in metabolism occur during aging of quiescent normal human fibroblasts (NHFs) and the mechanisms that regulate these changes. Bioenergetics measurements were performed in quiescent NHFs from younger (newborn, 3-d, 5-m, and 1-y) and older (58-y, 61-y, 63-y, 68-y, and 70-y) donors as well as NHFs from the same individual at different
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32

Sudama, Gita. "There are observable metabolic signature patterns in C. elegans specifically for different life stages grown with and without the added antioxidants Vitamin C and Vitamin E? /." Fairfax, VA : George Mason University, 2008. http://hdl.handle.net/1920/3088.

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Thesis (Ph.D.)--George Mason University, 2008.<br>Vita: p. 214. Thesis director: James D. Willett. Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Bioinformatics. Title from PDF t.p. (viewed July 7, 2008). Includes bibliographical references (p. 204-213). Also issued in print.
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Jacomini, André Mourão. "Exercício físico e estresse oxidativo: influência do nível de condicionamento físico na hipertensão arterial e na relação entre substâncias antioxidantes e oxidantes em idosos." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/17/17152/tde-08102015-165014/.

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Introdução: A hipertensão arterial sistêmica (HAS) tem sido apontada como um dos principais fatores de risco para as doenças cardiovasculares, especialmente para a população idosa. O estresse oxidativo e o sedentarismo têm sido apontados como fatores etiológicos da HAS. Níveis elevados de estresse oxidativo são caracterizados pelo aumento na produção de espécies reativas de oxigênio, que tem forte afinidade com o óxido nítrico, o qual tem participação no processo de controle da pressão arterial. O exercício físico tem sido apontado para a regulação dessa relação. Objetivos: Investigar a relaçã
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Li, Mengjia Hsuan Grace. "Evaluation of oxidative behavior of polyolefin geosynthetics utilizing accelerated aging tests based on temperature and pressure /." Philadelphia, Pa. : Drexel University, 2005. http://dspace.library.drexel.edu/handle/1860/467.

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Gangadharappa, Harish [Verfasser]. "Molecular events related to oxidative and nitrosative stress during brain aging, neurodegeneration and neurotrauma / Harish Gangadharappa." München : GRIN Verlag, 2020. http://d-nb.info/1205545492/34.

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Feng, Jinliu 1974. "Mitochondrial respiratory transportation is the key determinant of aging in Caenorhabditis elegans." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32991.

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'The rate of living' hypothesis of aging speculates that the metabolic rate of a species ultimately determines its life expectancy. Using the nematode worm Caenorhabditis elegans as model system, mutation in twp-1 (t&barbelow;ime w&barbelow;arp) gene was found to significantly delay biological timing and remarkably increase mean and maximum life span. The rate of living in twp-1 is dramatically delayed in all the biological processes we tested, including rates of rhythmic adult behaviors, development, and reproduction. Oxygen consumption, which indicates metabolic rate of an organism, is reduc
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Poppe, Sandra Castro. "Estresse oxidativo e envelhecimento." Universidade de São Paulo, 2001. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-11032019-102753/.

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Este trabalho enfatiza o estabelecimento de parâmetros relacionados ao estado de estresse oxidativo em uma população de idosos, avaliando-se: níveis de antioxidantes de baixo peso molecular no plasma, vitC, &#945;TC e &#946;CT assim como a sua ingestão alimentar diária; atividade das enzimas antioxidantes eritrocitárias (CuZn-SOD, CAT e GPX) níveis de produtos derivados da oxidação de lipídios, mais especificamente as substâncias reativas ao ácido tiobarbitúrico (SRAT) e a atividade do burst oxidativo em neutrófilos sanguíneos. Foram estudados 90 idosos, residentes na comunidade, com idade igu
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Heemann, Fernanda Maciel. "Avaliação do estresse oxidativo em cérebro de ratas reprodutoras ao longo do envelhecimento." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/141964.

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A reprodução é uma fase crítica e exigente na vida dos animais. Nos mamíferos, as fêmeas costumam investir muito mais no cuidado parental do que os machos e a lactação é o período mais exigente em termos energéticos da vida da fêmea. Aqui, testamos se o estresse oxidativo é uma consequência da reprodução em ratas Wistar. Foram avaliadas as atividades da glutationa peroxidase, glutationa S-transferase, superóxido dismutase, o consumo de peróxido de hidrogênio, carbonilação de proteínas, peroxidação lipídica, níveis de nitrito e nitrato, glutationa total, níveis de vitamina C, bem como os níveis
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39

Jones, Melanie. "Mechanisms Associated with Aging and Age-Related Disease in Drosophila." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2110.

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Aging is an intrinsic process that is independent of obvious disease. In contrast to normal aging, age-related diseases are conditions that typically manifest at advanced ages, are associated with explicit pathology and cause disability and premature death. We used Drosophila as a model to investigate the molecular-genetic mechanisms associated with aging and age-related disease. Age-related locomotor impairment (ARLI) is a serious condition for the elderly and greatly impacts their quality of life. Toward identifying genes and mechanisms that influence ARLI, we performed a forward genetic
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40

CREMONINI, Eleonora. "In vivo and in vitro data supporting the involvement of oxidative stress in aging-related and metabolic diseases." Doctoral thesis, Università degli studi di Ferrara, 2014. http://hdl.handle.net/11392/2388927.

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Background: Oxidative stress (OxS) is caused by the derangement of the balance between production of oxidants, mainly represented by reactive oxygen species (ROS), and the antioxidant’s ability to detoxify them. The consequent biomolecular oxidative damage tends to accumulate in aged biological systems and it is widely believed to act as main trigger of aging- and metabolism- related diseases such as late onset Alzheimer’s disease (LOAD), postmenopausal osteoporosis (PO) and metabolic syndrome (MetS). The involvement of OxS in these pathologies has been nicely demonstrated in vitro and an
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41

Cuevas, González Santiago. "Análisis de los factores de riesgo cardiovascular en el proceso de envejecimiento y su relación con el estrés oxidativo. Estudio piloto observacional." Doctoral thesis, Universidad de Murcia, 2008. http://hdl.handle.net/10803/10861.

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Estrés oxidativo e inflamación parecen jugar un papel importante en el proceso de envejecimiento relacionado con la disfunción del sistema cardiovascular humano. Hábitos de vida tales como fumar, consumo de alcohol y ejercicio físico, pueden alterar el estado redox de los tejidos y afectar la relación de los marcadores de estrés oxidativo con la edad. Se requiere Información sobre el estado oxidativo de las poblaciones humanas para verificar la función de daño oxidativo en el envejecimiento y los cambios relacionados con el sistema cardiovascular, con el fin de identificar cuáles son los facto
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42

Stab, II Bernd Robert. "The Effects of Cell Culture Oxygen Levels on the Replicative Senescence Processes of Primary Human Fibroblasts." Diss., Virginia Tech, 2009. http://hdl.handle.net/10919/28468.

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Serial passaging of primary human fibroblasts leads to the formation of non-dividing senescent cells by a process termed replicative senescence. This tissue culture-based methodology is currently used as a model system to determine the underlying mechanisms of in vivo cellular aging and tumor suppression. Senescence is regarded as an alternative pathway to apoptosis, where cells undergo multiple changes in metabolic and cellular signaling pathways in order to prevent proliferation but still maintain a metabolically-active cell. Whether or not this model accurately reflects in vivo processes is
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43

Opii, Wycliffe Omondi. "Oxidative stress and redox proteomics studies in models of neurodegenerative disorders I. the canine model of human aging ; II. insights into succesful [sic] aging ; and III. traumatic brain injury /." Lexington, Ky. : [University of Kentucky Libraries], 2006. http://lib.uky.edu/ETD/ukychem2006d00520/Final.pdf.

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Thesis (Ph. D.)--University of Kentucky, 2006.<br>Title from document title page (viewed Jan. 29, 2007). Document formatted into pages; contains: xviii, 430 p. : ill. (some col.). Includes abstract and vita. Includes bibliographical references (p. 353-426).
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44

Hindle, Allyson Gayle. "An evaluation of the impacts of aging on skeletal muscle performance in several mammalian divers." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-2615.

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45

Medlow, Paul Wallace. "The effects of aerobic exercise on oxidative stress and cardiovascular risk factors in aging and type II diabetes mellitus." Thesis, University of Ulster, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.601214.

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The oxidation of low-density lipoproteins (LDL) is considered a key step in the development and progression of atherosclerosis. Single bouts of aerobic exercise cause transient increases in free radical production that may enhance the susceptibility of LDL to oxidation and create a more atherogenic LDL particle. In contrast, chronic exercise has often been considered an effective tool in improving metabolic profile through changes in aerobic capacity, lipid profile, fuel utilization and oxidative stress in both healthy and disease populations. Despite this, less is known about how it may benef
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46

Martin, Ian. "Effects of Altered Superoxide Dismutase Expression on Age-related Functional Declines and Survival in Drosophila." VCU Scholars Compass, 2008. http://scholarscompass.vcu.edu/etd/1589.

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Most organisms experience progressive declines in physiological function as they age. A number of studies in a variety of species support a strong link between oxidative damage, age-related functional declines and life span determination. Here, manipulating the expression levels of superoxide dismutase (SOD) isoenzymes SOD1 and SOD2, resulted in altered functional senescence and survival characteristics in Drosophila. Overexpression of cytosolic Sod1 using the yeast GAL4/UAS system conferred a 30-34% increase in mean life span and resulted in an attenuated senescence of odor avoidance behavior
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47

Fu, Yu. "Modulating effects of Chinese green tea on hippocampal neurons against glutamate neurotoxicity and hippocampal dependent memory during aging in mice." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B32017893.

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48

Corenblum, Mandi J., Sneha Ray, Quentin W. Remley, et al. "Reduced Nrf2 expression mediates the decline in neural stem cell function during a critical middle-age period." WILEY-BLACKWELL, 2016. http://hdl.handle.net/10150/622598.

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Although it is known that the regenerative function of neural stem/progenitor cells (NSPCs) declines with age, causal mechanisms underlying this phenomenon are not understood. Here, we systematically analyze subventricular zone (SVZ) NSPCs, in various groups of rats across the aging spectrum, using in vitro and in vivo histological and behavioral techniques. These studies indicate that although NSPC function continuously declines with advancing age, there is a critical time period during middle age (13-15 months) when a striking reduction in NSPC survival and regeneration (proliferation and ne
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49

Wood, Emma Mary. "Causes and fitness consequences of telomere dynamics in a wild social bird." Thesis, University of Exeter, 2017. http://hdl.handle.net/10871/29777.

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Telomeres are increasingly used as biomarkers of somatic maintenance and could conceivably play a causal role in life history trade-offs. In this thesis, I use longitudinal telomere measures from a wild population of cooperatively breeding white-browed sparrow weavers (Plocepasser mahali) to further our understanding of the causes and fitness consequences of individual variation in somatic maintenance, with particular focus on hitherto unexplored effects of the social environment. In Chapter 2, I start by investigating the key prediction of life-history theory that shortfalls in somatic mainte
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50

CARROZZINI, TATIANA. "Nutrition interventions in aging: study of coffee-derived compounds antioxidant properties in an in vitro model of ischemia." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2021. http://hdl.handle.net/10281/309808.

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Negli ultimi secoli, l'aspettativa di vita è aumentata grazie a uno stile di vita migliore, ma di conseguenza sono aumentate le patologie legate all'invecchiamento. L'invecchiamento è un processo fisiologico complesso e modificazioni legate all'età sono evidenti anatomicamente e fisiologicamente nella BEE. L'accumulo di danno ossidativo alle macromolecole da parte di RONS e ROS in BEE può essere cruciale nello sviluppo e nella progressione di diverse patologie del SNC. In questa situazione l'ischemia cerebrale potrebbe alterare ulteriormente l'equilibrio ossidante/antiossidante a favore degli
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