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Zińczuk, Justyna, Konrad Zaręba, E. Konarzewska-Duchnowska, K. Guzińska-Ustymowicz, B. Kędra, A. Kemona y A. Pryczynicz. "Assessment of the presence of pancreatic intraepithelial neoplasia in various diseases of this organ". Progress in Health Sciences 7, n.º 2 (22 de septiembre de 2017): 43–49. http://dx.doi.org/10.5604/01.3001.0010.5718.
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<b>Purpose</b>: Pancreatic intraepithelial neoplasia (PanIN) is one of the most commonly occurring precancerous lesion in pancreas which leads to development of pancreatic ductal adenocarcinoma (PDAC). We assessed the presence and grade of pancreatic intraepithelial neoplasia in the course of various diseases of the pancreas and its correlations with chosen clinicopathological parameters. null <b>Results</b>: A total of 276 foci of PanIN were identified in 94 patients. The most common lesions were PanIN 1a and PanIN 1b which together constituted 68.2 % of all lesions, whereas the PanIN 2 was present in 21.7% and PanIN 3 in 10.1% of patients. No statistical differences were observed in gender tendency for the development of PanINs. There was correlation between age of patients and degree of PanIN (p=0.034). There is no statistical difference in PanIN frequency among patients with pancreatic ductal adenocarcinomas, neuroendocrine tumors, chronic pancreatitis and pancreatic cysts (p=0.592). <b>Conclusions</b>: Our study showed that important factor in development of pancreatic intraepithelial neoplasia is age and the presence of PanIN in nonneoplastic diseases in older people should be included to the group with increased risk of cancer development.
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Lin, Pei-Yu, Shih-Jung Peng, Chia-Ning Shen, Pankaj J. Pasricha y Shiue-Cheng Tang. "PanIN-associated pericyte, glial, and islet remodeling in mice revealed by 3D pancreatic duct lesion histology". American Journal of Physiology-Gastrointestinal and Liver Physiology 311, n.º 3 (1 de septiembre de 2016): G412—G422. http://dx.doi.org/10.1152/ajpgi.00071.2016.
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Pericytes and glial cells are accessory cells of neurovascular networks, which have been reported to participate in scar formation after tissue injury. However, it remains unclear whether similar reactive cellular responses occur in pancreatic intraepithelial neoplasia (PanIN). In this study we developed three-dimensional (3D) duct lesion histology to investigate PanIN and the associated pericyte, glial, and islet remodeling. Transparent mouse pancreata with a KrasG12D mutation were used to develop 3D duct lesion histology. Deep-tissue, tile-scanning microscopy was performed to generate panoramic views of the diseased pancreas for global examination of early stage and advanced duct lesion formation. Fluorescence signals of ductal and neurovascular networks were simultaneously detected to reveal associated remodeling. Significantly, in KrasG12D-mutant mice, when the low-grade PanINs emerge, duct lesions appear as epithelial buds with perilesional pericyte and glial activation. When PanINs occur in large scale (induced by cerulein injections to the mutant mice), the 3D image data identifies 1) aggregation of PanINs in clusters in space; 2) overexpression of the pericyte marker NG2 in the PanIN microenvironment; and 3) epithelial in-growth to islets, forming the PanIN-islet complexes. Particularly, the PanIN-islet complexes associate with proliferating epithelial and stromal cells and receive substantial neurovascular supplies, making them landmarks in the atrophic lobe. Overall, perilesional pericyte and glial activation and formation of the PanIN-islet complex underline cellular heterogeneity in the duct lesion microenvironment. The results also illustrate the advantage of using 3D histology to reveal previously unknown details of neurovascular and endocrine links to the disease.
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McGinnis, Timothy, Leonidas Bantis, Rashna Madan, Prasad Dandawate, Sean Kumer, Timothy Schmitt, Ravi Kumar Paluri, Anwaar Saeed y Anup Kasi. "Survival outcomes of pancreatic intraepithelial neoplasm (PanIN) versus intraductal papillary mucinous neoplasm (IPMN) associated pancreatic adenocarcinoma." Journal of Clinical Oncology 38, n.º 4_suppl (1 de febrero de 2020): 766. http://dx.doi.org/10.1200/jco.2020.38.4_suppl.766.
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766 Background: Pancreatic intraepithelial neoplasms (PanINs) and intraductal papillary mucinous neoplasms (IPMNs) are common pancreatic adenocarcinoma precursor lesions. However, data regarding their respective associations with prognosis is lacking. Methods: We retrospectively evaluated 72 resected pancreatic adenocarcinoma cases at the KU Cancer Center between Aug 2009 and March 2019. Patients were divided into either one of two groups, PanIN or IPMN, based on the results of the surgical path report. We compared baseline characteristics, overall and progression free survival between the two groups, as well as OS and PFS based on local or distant tumor recurrence. Results: 52 patients had PanIN and 20 patients had IPMN. Demographic and baseline characteristics are as follows (PanIN/IPMN): Median age 62.5/69; Gender (male) 63%/65%; ECOG status (0-1) 98%/85%; pancreatic head tumors 87%/70%; pancreatic body tumors 6%/15%; pancreatic tail tumors 7%/15%; Abnormal CA19-9 at diagnosis 79%/67%; Comorbidity Index 5/5 respectively. Median PFS was 26.2 months (95% CI: 21.4-31.0) for PanIN and 74.3 months (95% CI: 15.7-132.9) for IPMN [p = 0.004]. Median OS was 70.3 months (95% CI: 35.4-105.2) for PanIN and 78.8 months (95% CI: 33.2-124.4) for IPMN [p = 0.013]. Within the PanIN group, median OS after recurrence was 71.3 months (95% CI: 68.8.-73.4) for local recurrence and 46.7 months (95% CI: 39.2-54.2) for distant recurrence [p = 0.330]. Conclusions: Patients who had a IPMN associated pancreatic cancer had better PFS and OS when compared to patients with PanIN associated pancreatic cancer. In patients with PanIN associated cancer that recurred, OS was better with local recurrence compared to distant recurrence but did not meet statistical significance. The results need to be validated in a larger cohort. [Table: see text]
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McGinnis, Timothy, Leonidas E. Bantis, Rashna Madan, Prasad Dandawate, Sean Kumer, Timothy Schmitt, Ravi Kumar Paluri y Anup Kasi. "Survival Outcomes of Pancreatic Intraepithelial Neoplasm (PanIN) versus Intraductal Papillary Mucinous Neoplasm (IPMN) Associated Pancreatic Adenocarcinoma". Journal of Clinical Medicine 9, n.º 10 (25 de septiembre de 2020): 3102. http://dx.doi.org/10.3390/jcm9103102.
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Pancreatic intraepithelial neoplasms (PanINs) and intraductal papillary mucinous neoplasms (IPMNs) are common pancreatic adenocarcinoma precursor lesions. However, data regarding their respective associations with survival rate and prognosis are lacking. We retrospectively evaluated 72 pancreatic adenocarcinoma tumor resection patients at the University of Kansas Hospital between August 2009 and March 2019. Patients were divided into one of two groups, PanIN or IPMN, based on the results of the surgical pathology report. We compared baseline characteristics, overall survival (OS), and progression free survival (PFS) between the two groups, as well as OS and PFS based on local or distant tumor recurrence for both groups combined. 52 patients had PanINs and 20 patients had IPMNs. Patients who had an IPMN precursor lesion had better median PFS and OS when compared to patients with PanIN precursor lesions. However, the location of tumor recurrence (local or distant) did not show a statistically significant difference in OS.
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Sagami, Ryota, Kentaro Yamao, Jun Nakahodo, Ryuki Minami, Masakatsu Tsurusaki, Kazunari Murakami y Yuji Amano. "Pre-Operative Imaging and Pathological Diagnosis of Localized High-Grade Pancreatic Intra-Epithelial Neoplasia without Invasive Carcinoma". Cancers 13, n.º 5 (24 de febrero de 2021): 945. http://dx.doi.org/10.3390/cancers13050945.
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Pancreatic ductal adenocarcinoma (PDAC) arises from precursor lesions, such as pancreatic intra-epithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasm (IPMN). The prognosis of high-grade precancerous lesions, including high-grade PanIN and high-grade IPMN, without invasive carcinoma is good, despite the overall poor prognosis of PDAC. High-grade PanIN, as a lesion preceding invasive PDAC, is therefore a primary target for intervention. However, detection of localized high-grade PanIN is difficult when using standard radiological approaches. Therefore, most studies of high-grade PanIN have been conducted using specimens that harbor invasive PDAC. Recently, imaging characteristics of high-grade PanIN have been revealed. Obstruction of the pancreatic duct due to high-grade PanIN may induce a loss of acinar cells replaced by fibrosis and lobular parenchymal atrophy. These changes and additional inflammation around the branch pancreatic ducts (BPDs) result in main pancreatic duct (MPD) stenosis, dilation, retention cysts (BPD dilation), focal pancreatic parenchymal atrophy, and/or hypoechoic changes around the MPD. These indirect imaging findings have become important clues for localized, high-grade PanIN detection. To obtain pre-operative histopathological confirmation of suspected cases, serial pancreatic-juice aspiration cytologic examination is effective. In this review, we outline current knowledge on imaging characteristics of high-grade PanIN.
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Hwang, In kyeom, Bong Kyun Kang, Yoon Suk Lee, Jaihwan Kim y Jin-Hyeok Hwang. "Prognostic impact of pancreatic intraepithelial neoplasia (PanIN)-III accompanying chronic pancreatitis in patients who underwent R0 resection for pancreatic adenocarcinoma." Journal of Clinical Oncology 32, n.º 3_suppl (20 de enero de 2014): 246. http://dx.doi.org/10.1200/jco.2014.32.3_suppl.246.
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246 Background: The clinical significance of pancreatic intraepithelial neoplasia (PanIN)-III, known as carcinoma in situ of pancreatic ductal adenocarcinoma (PDAC), remains unclear yet. Recent research showed inflammation enhanced early cellular invasion of PanIN-III by facilitating epithelial to mesenchymal transition (EMT), even before frank malignancy in experimental model. Therefore we decided to investigate whether PanIN-III accompanying chronic pancreatitis (CP) might have an important prognostic impact in patient who underwent curative resection for PDAC. Methods: Medical records of 199 PDAC patients with R0 resection were reviewed. Presence and grade of PanIN and CP in resected specimen were determined based on College of American Pathologists protocol. Overall survival (OS) and disease free survival (DFS) were analyzed according to PanIN-III and CP. Results: CP was observed in 19.6% (39/199) of resected specimen and PanIN-III in 21.1% (42/199). In the group with CP, PanIN-III was associated with poor prognosis in univariate analysis (16.6 months vs. 32.0 months, P=0.001 for OS and 7.5 months vs. 15.1 months, p=0.012 for DFS), whereas PanIN-III was not a prognostic factor in the group without CP. When we divided into two groups [PanIN-III accompanying CP (n=12) vs. the others (n=187)], it showed that median DFS and OS were significantly shorter in PanIN-III and CP group than those of the others (7.5 months and 16.6 months vs. 12.4 months and 26.0 months, p=0.017 and p=0.003, respectively). In multivariate analysis, PanIN-III accompanying CP remained a statistically significant poor prognostic factor (HR: 2.06; 95% CI: 1.008 to 4.221; p=0.048 for OS, HR: 2.6; 95% CI: 1.267 to 5.462; P=0.009 for DFS using Cox proportional hazard ratio). Conclusions: PanIN-III accompanying CP might influence on poor long-term outcomes in patients who underwent R0 resection for PDAC. Therefore, it would support that chronic inflammation could enhance the dissemination of carcinoma in situ.
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Andriani, Andriani y Indah Permatasari. "Analisis Tingkat Kesehatan Bank dengan Metode RGEC Pada BCA Syariah dan Panin Dubai Syariah". IQTISHODUNA 17, n.º 1 (27 de abril de 2021): 65–80. http://dx.doi.org/10.18860/iq.v17i1.11521.
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This research is motivated by the development of increasingly rapid Islamic banking and increasing public trust in banks. Bank health services are one of the management controls because bank health is a reflection of the bank's performance. This study aims to see, describe and compare the soundness level of banks at BCA Syariah and Panin Dubai Syariah using the RGEC method (Risk Profile, GCG, Earning, Capital) with new SEOJK Number 10 / SEOJK.03 / 2014. The results show that the NPF BCA Syariah and Panin Dubai Syariah are in a very healthy position. FDR BCA Syariah is in a fairly healthy position and Panin Dubai Syariah is in an unhealthy position. ROA BCA Syariah and Panin Dubai Syariah are in a fairly healthy position. NOM BCA Syariah and Panin Dubai Syariah are in a healthy position. CAR BCA Syariah and Panin Dubai Syariah are in a very healthy position. The BCA Syariah GCG Report is in a very healthy position and the Panin Dubai Syariah GCG Report is in a healthy position. The analysis results show a significant difference between the performance of BCA Syariah and Panin Dubai Syariah, especially in the NPF, FDR, NOM and CAR variables, while there is no difference in the ROA variable.
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Wendt, Luiz Roberto, Alessandro Bersch Osvaldt, Vivian Pierre Bersch, Rita de Cássia Schumacher, Maria Isabel Albano Edelweiss y Luiz Rohde. "Pancreatic intraepithelial neoplasia and ductal adenocarcinoma induced by DMBA in mice: effects of alcohol and caffeine". Acta Cirurgica Brasileira 22, n.º 3 (junio de 2007): 202–9. http://dx.doi.org/10.1590/s0102-86502007000300008.
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PURPOSE: To evaluate the effects of alcohol and caffeine in a pancreatic carcinogenesis mouse model induced by 7,12-dimethylbenzantracene (DMBA), according to the PanIN classification system. METHODS: 120 male, Mus musculus, CF-1 mice were divided into four groups. Animals received either water or caffeine or alcohol or alcohol + caffeine in their drinking water. In all animals, 1 mg of DMBA was implanted into the head of the pancreas. After 30 days, euthanasia was performed; excised pancreata were then fixed in formalin, stained with hematoxylin-eosin and categorized as follows: normal ducts, reactive hyperplasia, PanIN-1A, PanIN-1B, PanIN-2, PanIN-3 or adenocarcinoma. RESULTS: PanIN lesions were verified in all groups. Adenocarcinoma was detected in 15% of animals in the caffeine group, 16.6% in the water group, 23.8% in the alcohol + caffeine group and 52.9% in the alcohol group (P<0.05). CONCLUSIONS: The experimental pancreatic carcinogenesis mouse model using DMBA effectively induces PanIN lesions and pancreatic adenocarcinoma. This study verified the association between alcohol use and pancreatic adenocarcinoma; caffeine did not present the same effect.
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Sato, Yasunori, Kenichi Harada, Motoko Sasaki y Yasuni Nakanuma. "Histological Characterization of Biliary Intraepithelial Neoplasia with respect to Pancreatic Intraepithelial Neoplasia". International Journal of Hepatology 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/678260.
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Biliary intraepithelial neoplasia (BilIN) is a precursor lesion of hilar/perihilar and extrahepatic cholangiocarcinoma. BilIN represents the process of multistep cholangiocarcinogenesis and is the biliary counterpart of pancreatic intraepithelial neoplasia (PanIN). This study was performed to clarify the histological characteristics of BilIN in relation to PanIN. Using paraffin-embedded tissue sections of surgically resected specimens of cholangiocarcinoma associated with BilIN and pancreatic ductal adenocarcinoma associated with PanIN, immunohistochemical staining was performed using primary antibodies against MUC1, MUC2, MUC5AC, cyclin D1, p21, p53, and S100P. For mucin staining, Alcian blue pH 2.5 was used. Most of the molecules examined here showed similar expression patterns in BilIN and PanIN, in which their expression tended to increase along with the increase in atypia of the epithelial lesions. Significant differences were observed in the increase in mucin production and the expression of S100P in PanIN-1 and the expression of p53 in PanIN-3, when compared with those in BilIN of a corresponding grade. These results suggest that cholangiocarcinoma and pancreatic ductal adenocarcinoma share, at least in part, a common carcinogenic process and further confirm that BilIN can be regarded as the biliary counterpart of PanIN.
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McAllister, Florencia, Jennifer M. Bailey, Janivette Alsina, Christopher Nirschl, Jeffrey Roeser, Danielle Blake, Rachana Lankapali et al. "TH17 cells and early pancreatic tumorigenesis." Journal of Clinical Oncology 31, n.º 4_suppl (1 de febrero de 2013): 144. http://dx.doi.org/10.1200/jco.2013.31.4_suppl.144.
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144 Background: Chronic pancreatitis increases the risk of developing pancreatic ductal adenocarcinoma (PDAC), one of the deadliest human cancers. Activating Kras mutations have been detected in 30% of early pancreatic intraepithelial neoplasias (PanINs), increasing to 100% in PDAC. We hypothesized that inflammatory cells recruited to the pancreas in response to chronic injury can interact with epithelial cells harboring activated KrasG12D and affect the progression of PanIN lesions. Methods: We used the the transgenic Mist1:CreERT2; LSL-KrasG12D (KCiMist1) adult mice in which the LSL KrasG12Dallele is activated specifically in the acinar compartment. This model leads to the formation of PanINs with a classic "ductal" phenotype and the progression of lesions is accelerated by the induction of chronic pancreatitis with recurrent cerulein injections. Results: We have found that TH17 cells, a subtype of CD4+ T-helper cells known to play an active role in inflammation, are recruited to the pancreas during chronic pancreatitis and further increased upon KrasG12Dactivation. The differentiation of CD4+T cells into TH17 requires IL-6 and TGF-B, factors that are increased in the pancreatic tumor microenvironment. Stat3, a key transcription factor that determines the differentiation of TH17 lineage, is activated in the pancreatic dysplastic epithelium and in the stroma. We have discovered that PanINs from KCiMist1 mice overexpress the IL-17 Receptor (IL-17RA) by immunofluorescence and furthermore we confirmed this finding on human PanIN tissue arrays. Intrapancreatic injections of adenovirus encoding IL-17A, the main cytokine produced by TH17 cells, into KCiMist1 mice led to an increase in the progression of PanIN lesions by 6 weeks when compared with mice injected with control adenovirus. Finally, we transplanted IL-17-/- bone marrow into KCiMist1 mice and showed a significant decrease in metaplasia and PanINs formation when compared with mice transplanted with WT bone marrow. Conclusions: We found that TH17 cells, recruited to the pancreas in the presence of chronic pancreatitis, can accelerate the progression of early pancreatic tumorigenesis, setting the basis for future translational studies targeting TH17 cells.
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Alhimnie, Firly Aulia y Dina Fitrisia Septiarini. "ANALISIS TEKNIK MITIGASI RISIKO PRODUK TAKE OVER KPR PADA BANK PANIN DUBAI SYARIAH CABANG SURABAYA". Jurnal Ekonomi Syariah Teori dan Terapan 7, n.º 6 (11 de julio de 2020): 1074. http://dx.doi.org/10.20473/vol7iss20206pp1074-1090.
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This research aims to determine the risk mitigation technique for home financing takeover-funded products. The method used for this research is descriptive qualitative-case study. The data gained from this research is a primary data from an interview with three sources from Panin Dubai Sharia bank, and a secondary data of documentation and financial report of Panin Dubai Sharia Bank. The result of this research is Panin Dubai Sharia bank used reduction mitigation technique either on credit risk or operational risk. On the operational risk, Panin Dubai Sharia bank prepared document takeover and properties takeover further before the contract is done, and implementing Take over Operational Day only on Monday and Thursday. Meanwhile, for credit risk, Panin Dubai Sharia Bank used 4 kinds of systems such as backup of credentials, guarantees, internal ratings, computer models.Keywords: Mitigation, Risk, Take Over, KPR
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Ito, Hiroyuki, Yoshiaki Kawaguchi, Yohei Kawashima, Atsuko Maruno, Masami Ogawa, Kenichi Hirabayashi y Tetsuya Mine. "A Case of Pancreatic Intraepithelial Neoplasia That Was Difficult to Diagnose Preoperatively". Case Reports in Oncology 8, n.º 1 (22 de enero de 2015): 30–36. http://dx.doi.org/10.1159/000371842.
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A 63-year-old female patient presented to a local physician with pain in her back and epigastric region. An abdominal computed tomography (CT) scan revealed a pancreatic tumor, and the patient was referred to our hospital. Multiple imaging studies that included ultrasonography (US), CT, MRI, and endoscopic US revealed a cystic lesion 3-4 cm in size with node-like projections in the body of the pancreas. The distal main pancreatic duct was also found to be dilated. Endoscopic retrograde pancreatography revealed an irregular stenosis of the main pancreatic duct proximal to the cystic lesion, and malignancy was suspected. The patient was preoperatively diagnosed with pancreatic ductal carcinoma concomitant with intraductal papillary mucinous carcinoma, and a distal pancreatectomy was performed. Rapid pathological diagnosis during surgery revealed positive surgical margins for pancreatic intraepithelial neoplasia (PanIN). Further resection was performed twice, her surgical margin was positive and total pancreatectomy was ultimately conducted. Histopathological findings revealed diffuse microinvasive cancerous lesions corresponding to PanIN-2 (moderate dysplasia) to PanIN-3 (carcinoma in situ) throughout the pancreas. PanIN involves microlesions of the ductal epithelium that may precede pancreatic cancer. Ascertaining changes in PanIN using images provided by diagnostic modalities such as CT and US is challenging. Ductal stenosis and distal cystic lesions resulting from atrophy and fibrosis of pancreatic tissue were noted around PanIN. Considering the possibility of PanIN, a precancerous lesion during differential diagnosis will help to improve early detection and prognosis for patients with pancreatic cancer.
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Saniy, Afina Rusyida y Ainur Rochmaniah. "PENGARUH STRATEGI COSTUMER RELATIONS PT BANK PANIN CABANG SIDOARJO TERHADAP LOYALITAS NASABAH TABUNGAN MIKRO PANIN". KANAL: Jurnal Ilmu Komunikasi 3, n.º 2 (1 de octubre de 2016): 193. http://dx.doi.org/10.21070/kanal.v3i2.308.
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The purposes of this research to analyze and explain the influence of customer relations strategies in the PT. Panin Bank branch A. Yani Sidoarjo towards customer loyalty micro savings Panin. This research used quantitative research with survey research methods. Meanwhile, the subject of this study is micro panin savings customers as many as 100 customers were selected using purposive sampling technique. Partial test (t test) showed that strategy of customer campaign dependent as independent variables which are marketing campaign,customer campaign and service quality that is affected towards dependent variable, namely customer loyalty PT. Panin Bank branch A. Yani Sidoarjo. The simultant test (Test F) indicated that the customer campaign strategy dependent as independent variables which are marketing campaign, customer campaign and service quality are affected towards dependent variable, namely customer loyalty PT. Panin Bank branch A.Yani Sidoarjo. Results analysis of the determination (R2) coefficient indicated that there is a relationship between all independent variables namely marketing campaign, customer campaign and service quality towards dependent
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Mutakhidah, Rokhmah y Yacobo P. Sijabat. "Analisis Analisis Kebangkrutan dengan Model Altman Z-score pada PT Bank Panin Dubai Syariah Tbk tahun 2016-2019". Jurnal Ekonomika : Manajemen, Akuntansi, dan Perbankan Syari'ah 9, n.º 2 (24 de septiembre de 2020): 1–14. http://dx.doi.org/10.24903/je.v9i2.931.
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The aims of study is to determine whether there is still a potential bankruptcy at PT Bank Panin Dubai Syariah Tbk from 2016-2019. This study used the model of Altman Z-Modified Model. The analyze is by looking at financial statements and financial ratios. The sample used in this study was PT. Bank Panin Dubai Syariah Tbk. Year 2016-2019. The results of the study stated that PT Bank Panin Dubai Syariah Tbk is far from potential bankruptcy with the Z-Score being above the threshold. But there are still not optimal in the financial statements such as retained earnings and profits generated by PT Bank Panin Dubai Syariah Tbk.Keywords: Bankruptcy, Financial statements, Altman Z-Score Modified Model
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Panjaitan, Julfrida. "pengaruh perubahan dan budaya organisasi terhadap kinerja karyawan melalui komitmen organisasi". JURNAL DINAMIKA MANAJEMEN DAN BISNIS 2, n.º 1 (26 de abril de 2019): 54–65. http://dx.doi.org/10.21009/jdmb.02.1.4.
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Abstrak
Perkembangan teknologi informasi pada bidang perbankan berdampak pada pergeseran pola bisnis konvensional ke arah digital. Pergeseran ini menyebabkan perubahan struktural dan pengurangan jumlah karyawan pada bank- bank di Indonesia. Pada PT Bank Panin KCU Plaza Pasifik terjadi hal sebaliknya yaitu jumlah karyawan bertambah tiap tahunnya namun kinerja karyawan mengalami penurunan padahal sudah ada budaya organisasi yang jelas dan komitmen organisasi dalam peningkatan sumber daya manusia. Penelitian ini dilakukan untuk mengetahui dan menganalisis pengaruh perubahan organisasi dan budaya organisasi terhadap kinerja karyawan dengan komitmen organisasi sebagai variabel intervening di PT bank Panin KCU Plaza Pasifik. Populasi dalam penelitian ini adalah seluruh karyawan tetap PT Bank Panin KCU Plaza Pasifik yang berjumlah 210 orang karyawan. Penelitian tesis ini menggunakan metode kuantitatif. Pengumpulan data diperoleh melalui kuisioner yang telah diisi oleh karyawan PT Bank Panin KCU Plaza Pasifik. Dalam menganalisis data, peneliti menggunakan teknik analisa structur equestion modelling (SEM) dengan menggunakan software statistik Partial Least Square (PLS). Hasil penelitian menunjukan bahwa perubahan organisasi berpengaruh signifikan terhadap kinerja karyawan di PT Bank Panin KCU Plaza Pasifik, budaya organisasi berpengaruh signifikan terhadap kinerja karyawan di PT Bank Panin KCU Plaza Pasifik, komitmen organisasi berpengaruh signifikan terhadap kinerja karyawan di PT Bank Panin KCU Plaza Pasifik, perubahan organisasi berpengaruh signifikan terhadap komitmen organisasi, budaya organisasi berpengaruh signifikan terhadap komitmen organisasi, perubahan organisasi berpengaruh signifikan terhadap kinerja karyawan melalui komitmen organisasi, dan budaya organisasi berpengaruh signifikan terhadap kinerja karyawan melalui komitmen organisasi.
Kata Kunci – Perubahan Organisasi, Budaya Organisasi, Komitmen Organisasi , Kinerja Karyawan
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Supriyono, Supriyono, Ahmad Rodoni, Yacop Suparno, Hermadi Hermadi y Hilyatun Nafisah. "EFFICIENCY PERFORMANCE ANALYSIS OF PANIN DUBAI SYARIAH BANK IN COLLECTING AND DISTRIBUTING THIRD PARTY FUNDS BEFORE AND AFTER MERGER". I-Finance: a Research Journal on Islamic Finance 5, n.º 1 (1 de julio de 2019): 46–56. http://dx.doi.org/10.19109/ifinace.v5i1.3716.
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In this study, the researcher would make Panin Dubai Syariah Bank was the object of research on Islamic banks that carry out mergers and acquisitions. This research by using quarterly financial reports to determine the level of efficiency of the Panin Dubai Syariah Bank to be analyzed using the Data Envelopment Analysis (DEA) method. The researcher was used the annual report to find out the extent the Panin Dubai Syariah Bank carries out its Shariah values and objectives to be analyzed based on the Maqashid Index Sharia. The frontier approach can be divided into parametric approaches and non-parametric approaches. The parametric approach takes measurements using stochastic econometrics and seeks to eliminate interference from the effects of inefficiency. While the non-parametric approach with linear programs ( non-parametric linear programming approach ) performs non-parametric measurements using an approach is not stochastic and tends to combine the interference into inefficiency. This is based on the discovery and observation of the population and evaluates efficiency relative to the units observed. In the non- parametric method, the approaches that can be used are Data Envelopment Analysis (DEA) and Free Disposal Hull (FDH). The results of the measurement of Bank Panin Dubai Syariah using DEA indicate that the decision to merge carried out by Panin Syariah Bank with Dubai Islamic Bank was the right decision because, with the merger, Panin Dubai Syariah Bank could produce almost perfect efficiency value of 99% in the year 2015. With doing the merger, Bank Panin Dubai Syariah can minimize the inefficiencies that occur in the input variable so that it can maximize the efficiency that occurs in the output variable
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Sembiring, Hendri. "PENGARUH KOMITMEN ORGANISASI DAN MOTIVASI TERHADAP KINERJA PEGAWAI PT. PANIN Tbk MEDAN". Jurakunman (Jurnal Akuntansi dan Manajemen) 14, n.º 2 (20 de agosto de 2021): 138. http://dx.doi.org/10.48042/jurakunman.v14i2.77.
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Penelitian ini bertujuan untuk mengetahui pengaruh komitmen organisasi dan motivasi terhadap kinerja pegawai pada PT. Panin Bank Tbk Medan sampel penelitian seluruh karyawan Divisi Retail Lending Marketing pada PT. Panin Bank Tbk – Medan yang berjumlah 32 orang Penelitian ini menggunakan metode penelitian deskriptif kuantitatif pengujian dalam penelitian ini menggunakan analisis regresi linier berganda. Kesimpulan menunjukkan secara parsial simultan dan komitmen organisasi dan motivasi berpengaruh signifikan terhadap kinerja pegawai pada PT. Panin Bank Tbk Medan.
Kata kunci : Komitmen Organisasi, Motivasi, Kinerja Pegawai
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Schwartz, Patrick B., Morgan T. Walcheck, Kristina A. Matkowskyj, Christopher A. Bradfield y Sean M. Ronnekleiv-Kelly. "12382 Circadian Disruption in Pancreatic Cancer Carcinogenesis". Journal of Clinical and Translational Science 5, s1 (marzo de 2021): 7–8. http://dx.doi.org/10.1017/cts.2021.421.
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ABSTRACT IMPACT: Circadian disruption is known to cause significant human pathology but has not been evaluated in pancreas cancer carcinogenesis; through understanding how disruption of circadian rhythms can lead to pancreas cancer development and spread, preventive and therapeutic strategies can be devised. OBJECTIVES/GOALS: Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer due to early spread and poor response to therapy. Identifying factors driving PDAC growth could lead to new therapeutic strategies. Thus, we evaluated the extent to which circadian rhythm disruption, a factor strongly associated with cancer formation, contributes to PDAC pathogenesis. METHODS/STUDY POPULATION: To achieve the objective, we evaluated mice with pancreas lineage Kras-mutation (KC mice), which are predisposed to develop the full spectrum of pancreas cancer precursor lesions (pancreatic intra-epithelial neoplasia or PANIN-1, 2, 3) and PDAC. We subjected KC mice to a light-dark phase shift protocol known to induce circadian disruption (KCCD, n = 18), and another group to standard lighting conditions (KCNC, n = 31), with equal numbers of males and females in each group. The mice were allowed access to food and water ad libitum until sacrifice at age 9 months. Histopathologic evaluation of the pancreas was then performed to assess for pancreatic inflammation, pancreatic precursor lesions (PANIN) and PDAC. Fisher’s Exact Test was used to evaluate differences in incidence. RESULTS/ANTICIPATED RESULTS: As expected, both groups of mice demonstrated 100% incidence of chronic pancreatitis and PANIN-1 (low-grade precursor lesion) at age 9 months. This is consistent with the KC phenotype. However, the KCCD mice demonstrated a significant increase in acute pancreatic inflammation (61.1% vs 19.4%, p = 0.005) compared to KCNC mice. Furthermore, intermediate grade precursor lesions (PANIN-2) were also significantly increase in the KCCD mice (38.9% vs 6.5%, p = 0.006). Incidence of high-grade precursor lesions (PANIN-3, or carcinoma in situ: 22.2% vs 9.7%) and PDAC (27% vs 19%) were also increased, but these were not statistically significant. These results are notable given the established progression from higher grade premalignant PANIN lesions (PANIN-2, PANIN-3) to PDAC. DISCUSSION/SIGNIFICANCE OF FINDINGS: Insight into how circadian disruption leads to increased PANIN-2 formation and increase in acute inflammation may be advantageous for understanding circadian disruption in PDAC carcinogenesis. The circadian clock is present in immune cells and disruption can induce immune dysregulation. This mechanism will be evaluated in follow up studies.
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Kesuma, Bronto y Harun Syamsuddin. "PENGARUH GAYA KEPEMIMPINANDEMOKRATIS DAN MOTIVASI TERHADAP KINERJA KARYAWAN PT.PANIN BANK CABANG ATMO PALEMBANG". Jurnal Ecoment Global 4, n.º 2 (19 de agosto de 2019): 103. http://dx.doi.org/10.35908/jeg.v4i2.758.
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<p>This study aims to determine the effects of leadership style and motivation on Employee Performance PT. Panin Bank Cabang Atmo Palembang, either simultaneously or partialy. The hypothesis purpose It is suspected that there is an influence between the Democratic leadership style on the Employee Performance of PT. Panin Bank Atmo Branch Palembang. Allegedly there is an influence between Motivation on Employee Performance of PT. Panin Bank Atmo Branch Palembang. It is suspected that there is an influence between the Style of Democratic Leadership and Motivation simultaneously on the Employee Performance of PT. Panin Bank Atmo Branch Palembang. The study population was all employees of PT. Panin Bank Cabang Atmo Palembang which totaled 30 people, the study sample using sampling satured with details of the sample to be tested instrumen and sample data analysis by 37 respondens. From the discussion that has been described, then conclusions can be drawn as follows; The results of testing the research hypothesis there is an effect of Motivation on the Performance of employees of PT.Panin Bank Branch Atmo Palembang, the results of testing the hypothesis that there is no influence of the Democratic leadership style on the performance of employees of PT. Panin Bank Atmo Branch Palembang, and the results of testing the hypothesis that there is an influence between democratic leadership style and motivation together on the performance of employees of PT. Panin Bank Atmo Branch Palembang.<strong></strong></p><p><strong><br /></strong></p><p><strong>Keywords: </strong>Style of Democratic Leadership, Motivation and Performance</p>
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Shela, Modis April y I. Gede Arimbawa. "The Influence of Cash Pick Up, Promotion and Cross-selling to Trust and Saving Decision". Journal of World Conference (JWC) 1, n.º 1 (8 de febrero de 2019): 194–200. http://dx.doi.org/10.29138/prd.v1i1.57.
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The purpose of this study is to analyze the influence of cash pick up, promotion, and cross-selling to trust and saving decision in Panin Bank sub branch office Kenjeran Surabaya city. Research methods used in this study was the quantitative approach. The sample in this research is as many as 100 people of the total National Savings customer Micro (TAMI) Panin Bank Sub branch Kenjeran, with technique insindental sampling, and collection data techniques with the use of a questionnaire. In this study researchers using the technique of data analysis using PLS SmartPLS 3 software Partial Least Square. The results of this study found that cash pick up, promotions, and cross-selling a positive and influence against trust and saving decision in Panin Bank sub branch office Kenjeran with variable promotions need to be a particular concern by Panin Bank, because influential directly or indirectly against trust and saving decisions
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du Rieu, Maël Chalret, Jérôme Torrisani, Janick Selves, Talal Al Saati, Anny Souque, Marlène Dufresne, Gregory J. Tsongalis et al. "MicroRNA-21 Is Induced Early in Pancreatic Ductal Adenocarcinoma Precursor Lesions". Clinical Chemistry 56, n.º 4 (1 de abril de 2010): 603–12. http://dx.doi.org/10.1373/clinchem.2009.137364.
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Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) has the poorest overall prognosis among gastrointestinal cancers; however, curative resection in early-stage PDAC greatly improves survival rates, indicating the importance of early detection. Because abnormal microRNA production is commonly detected in cancer, we investigated noninvasive precursor pancreatic intraepithelial neoplasia (PanIN) lesions for microRNA production as a potential early biomarker of PDAC. Methods: Pathologists identified and classified ductal lesions. We extracted total RNA from laser-capture microdissected PanIN tissue samples from a conditional KRAS(G12D) mouse model (n = 29) or of human origin (n = 38) (KRAS is v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog). MicroRNA production was quantified by quantitative real-time PCR. Internal controls included 5S and U6 RNAs. Results: Production of microRNAs miR-21, miR-205, and miR-200 paralleled PanIN progression in the KRAS(G12D) mouse model, compared with microRNA production in samples of nonpathologic ducts. miR-21 demonstrated the highest relative concentrations in the precursor lesions. Interestingly, miR-205 and miR-21 up-regulation preceded phenotypic changes in the ducts. The production of microRNAs miR-21, miR-221, miR-222, and let-7a increased with human PanIN grade, with peak production occurring in hyperplastic PanIN-2/3 lesions. In situ hybridization analysis indicated miR-21 production to be concentrated in pathologic ductal cells. miR-21 production was regulated by KRAS(G12D) and epidermal growth factor receptor in PDAC-derived cell lines. Conclusions: Aberrant microRNA production is an early event in the development of PanIN. Our findings indicate that miR-21 warrants further investigation as a marker for early detection of PDAC.
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Nurlina. "THE EFFECT OF WELFARE BENEFITS TOWARD EMPLOYEE PERFORMANCE AT PT. BANK PANIN, TBK IN MAKASSAR CITY". Advances in Social Sciences Research Journal 7, n.º 11 (8 de diciembre de 2020): 445–51. http://dx.doi.org/10.14738/assrj.711.9366.
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This study aims to determine the effect of welfare benefits toward employee performance at PT. Bank Panin, Tbk in Makassar City.
This research is a quantitative research. The population in this study were all employees at PT Bank Panin, Tbk in Makassar City, of 228 people. Then the sample is the author takes 20 percent of the population, of 46 people. Data collection methods are carried out by observation, documentation, and questionnaires. The data analysis technique used is a simple linear regression analysis for hypothesis testing.
The results showed that providing welfare benefits to employees had a positive and significant effect on employee performance at PT. Bank Panin, Tbk in Makassar City.
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Bara, Jacques y Marie-Elisabeth Forgue-Lafitte. "Cytoplasmic MUC1 in PanIN-1". Clinical Cancer Research 14, n.º 16 (12 de agosto de 2008): 5306.1–5306. http://dx.doi.org/10.1158/1078-0432.ccr-08-0402.
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Hartley-Kroeger, Fiona. "Stalking Shadows by Cyla Panin". Bulletin of the Center for Children's Books 75, n.º 1 (2021): 27. http://dx.doi.org/10.1353/bcc.2021.0475.
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Wiryawan, Muhammad Ryzki Wiryawan y Cici Amalia Hidayati Sulaiman. "Analisis SWOT Pada Layanan Jasa Mobile Banking Di PT Bank Panin Dubai Syariah". JSMA (Jurnal Sains Manajemen dan Akuntansi) 12, n.º 2 (18 de noviembre de 2020): 141–58. http://dx.doi.org/10.37151/jsma.v12i2.61.
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Dalam beberapa tahun terakhir, Bank telah menyesuaikan layanan perbankannya, dari yang sebelumnya berbasis kertas menjadi berbasis seluler atau mobile. Adopsi Mobile-banking telah mendapat perhatian lebih dalam beberapa tahun terakhir, karena memang ada lebih banyak telepon daripada komputer di pasaran. Di Indonesia, satu per satu bank mulai mengadopsi teknologi tersebut untuk bisa bersaing, salah satunya Bank Panin Dubai Syariah yang memulainya pada 2019. Penelitian ini mencoba menganalisis layanan jasa mobile banking di PT Bank Panin Dubai Syariah menggunakan pendekatan SWOT. Penelitian ini menggunakan metode kualitatif deskriptif, Menggunakan teknik pengumpulan data berupa observasi, wawancara, dokumentasi, dan studi pustaka. Studi menunjukan bahwa berdasarkan diagram cartesius, layanan Mobile Banking Bank Panin Dubai Syariah berada pada kuadran I (satu) yaitu mendukung growth oriented strategy (strategi agresif).
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Nasution, Miftah Fadil. "The Effect of Clarity on Budget Targets and Accounting Controls on Managerial Performance in Panin Sekuritas". Journal of Management Science (JMAS) 4, n.º 3 (1 de agosto de 2021): 93–97. http://dx.doi.org/10.35335/jmas.v4i3.109.
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This study aims to identify and understand the influence of Systems and Control Budget Goal Clarity Accounting against Managerial Performance in Panin Securities Company. The population in this study were all employees of PT. Panin Securities, Tbk branch of Iskandar Muda, Medan. Hypothesis testing using descriptive analysis method, statistical analysis method which consists of a multiple linear regression analysis, significant simultaneous testing (Test F), partial significance testing (t test) and test the coefficient of determination (R2). Results of this study indicate that the independent variable, ie a variable budget goal clarity and accounting control systems and a significant positive effect on managerial performance at PT. Panin Securities, Tbk. On testing simultaneously (Test F) note that the variable budget goal clarity and accounting control systems together positive and significant effect on managerial performance. In the partial test (t test) showed that the variables that budget goal clarity dominant influence on managerial performance at PT. Panin Securities where one unit increase in variable budget goal clarity will improve managerial performance by 0279, while the increase in one unit of accounting control system variables (X2) when compared with the effect of budget goal clarity variable (X1) will only improve managerial performance by 0.199.
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Satria, Edia. "Pengaruh Kualitas Pelayanan dan Kepuasan Nasabah Terhadap Switching Intention pada Nasabah Bank Panin Kota Sungai Penuh Periode Tahun 2016". J-MAS (Jurnal Manajemen dan Sains) 4, n.º 1 (29 de abril de 2019): 131. http://dx.doi.org/10.33087/jmas.v4i1.80.
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This study aimed to find out 1) what is the influence of service quality to switching intention to Bank Panin customers of Sungai Penuh City? 2) the extent to which the effect of customer satisfaction on switching intention on customer Bank Panin Sungai Penuh City? 3) the extent of the influence of service quality to switching intention either directly or indirectly? 4) the extent to which customer satisfaction satisfaction of customer service to switching intention either directly or indirectly? The population in this research is Bank Panin customer period 2016. hence got sample size 51 customer with accidental sampling, sampling technique. The data analysis tool used is path analysis at alpha level of 0.05. Based on the result of research indicate that service quality has no significant effect to switching intention, customer satisfaction has positive and significant effect to switching intention.
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Irwan, Irwan y M. Rimawan. "Analisis Non Performing Loan pada PT Panin Bank Tbk". Owner (Riset dan Jurnal Akuntansi) 4, n.º 2 (29 de junio de 2020): 330. http://dx.doi.org/10.33395/owner.v4i2.227.
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Penelitian ini bertujuan untuk menguji dan menganalsis tingkat Non Performing Loan (NPL) dimana membandingkan tingkat kredirt bermaslah (kredit kurang lancar,diragukan dan macet) dengan Total Kredit pada PT Panin Bank Tbk dimana semakin tinggi nilai Non Performing Loan (NPL) maka semakin buruk pengelolaan kredit begitu juga sebaliknya apabila nilai Non Performing Loan rendah pengelolaan kredit semakin baik. Populasi dalam penelitian ini adalah 37 tahun dan sampel dalam penelitian ini selama 9 tahun mulai 2010 sampai tahun 2018 dengan sampling yang digunakan adalah purposive sampling. Uji statistik mengunakan SPSS v 21 dengan teknik analsisis data menggunakan metode one sample t-test. hasil penelitian menunujukan bahwa non performig loan pada PT Panin Bank Tbk dikatakan sehat. Ini menunjukan bahwa pengelolaan dan penyaluran kredit yang diberikan oleh PT Panin Bank Tbk sudah baik dan berada dibawah ketetapan umum oleh Bank Indonesia.
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Reichert, Maximilian, Karin Blume, Alexander Kleger, Daniel Hartmann y Guido von Figura. "Developmental Pathways Direct Pancreatic Cancer Initiation from Its Cellular Origin". Stem Cells International 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/9298535.
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Pancreatic ductal adenocarcinoma (PDA) is characterized by an extremely poor prognosis, since it is usually diagnosed at advanced stages. In order to employ tools for early detection, a better understanding of the early stages of PDA development from its main precursors, pancreatic intraepithelial neoplasia (PanIN), and intraductal papillary mucinous neoplasm (IPMN) is needed. Recent studies on murine PDA models have identified a different exocrine origin for PanINs and IPMNs. In both processes, developmental pathways direct the initiation of PDA precursors from their cellular ancestors. In this review, the current understanding of early PDA development is summarized.
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Kawanishi, Aya, Kenichi Hirabayashi, Misuzu Yamada, Yumi Takanashi, Atsuko Hadano, Yoshiaki Kawaguchi, Toshio Nakagohri, Naoya Nakamura y Tetsuya Mine. "Clinicopathological significance of Necl-4 expression in pancreatic ductal adenocarcinoma". Journal of Clinical Pathology 70, n.º 7 (15 de diciembre de 2016): 619–24. http://dx.doi.org/10.1136/jclinpath-2016-204028.
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AimsThe loss, or decreased expression, of nectin-like molecule 4 (Necl-4; an immunoglobulin-like cell adhesion molecule) is reported to be associated with the development and progression of certain types of cancer. We investigated the clinicopathological significance of Necl-4 expression in patients with pancreatic ductal adenocarcinoma (PDAC).MethodsImmunohistochemical analyses of Necl-4 (n=258) and E-cadherin (n=256) expression were performed using tissue microarray blocks of PDAC samples. Necl-4 expression of 38 pancreatic intraepithelial neoplasia (PanIN) lesions included in tissue microarray cores was also evaluated. Necl-4 and E-cadherin expression was considered positive if >30% of cells were stained, and negative if ≤30% of cells were stained.ResultsNecl-4 expression was positive in 45.7% (n=118) and negative in 54.3% (n=140) of PDAC cases. Necl-4 staining was positive in 96.7% (n=29) and negative in 3.3% (n=1) of low-grade PanIN cases, and positive in 62.5% (n=5) and negative in 37.5% (n=3) of high-grade PanIN cases. The number of cases with positive Necl-4 expression decreased in the order low-grade PanIN>high-grade PanIN>PDAC (p<0.001). Negative Necl-4 expression was significantly associated with a larger tumour size of >30 mm, perineural invasion, lymphatic involvement, lymph node metastasis (pN1), an advanced TNM (tumour, node, metastases) stage (stage IIB–IV), an advanced histological grade (G2/3), and shorter overall survival. E-cadherin staining was positive in 46.1% (n=118) and negative in 53.9% (n=138) of PDAC cases. Necl-4 expression correlated positively with E-cadherin expression (r=0.405, p<0.001).ConclusionsThe results suggest that Necl-4 is associated with carcinogenesis and aggressiveness of PDAC.
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Abdullah, Kemas Afandi, Luis Marnisah y Siti Komariah Hildayanti. "PENGARUH BRAND EQUITY TERHADAP LOYALITAS NASABAH PT. BANK PANIN DUBAI SYARIAH, TBK. CABANG PALEMBANG". Jurnal Ecoment Global 3, n.º 1 (15 de febrero de 2018): 64. http://dx.doi.org/10.35908/jeg.v3i1.358.
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<p>Penelitian ini bertujuan untuk menganalisis pengaruh <em>Brand Awareness, Brand association, perceived quality, Brand loyalty </em>terhadap loyalitas nasabah PT. Bank Panin Dubai Syariah Bank, Tbk. Cabang Palembang, secara parsial dan secara bersama terhadap loyalitas nasabah PT. Bank Panin Dubai Syariah Bank, Cabang Palembang. Didisain menggunakan analisis kuantitatif deskriptif, dengan sampel sebanyak 92 nasabah yang diambil dari 1126 nasabah dengan menggunakan Teknik Sloven. Pengumpulan data menggunakan Teknik kuesioner dan data diolah dengan tools analisis SPSS 22.</p><p>Melalui uji hipotesis dapat diketahui bahwa Brand awareness tidak dapat memengaruhi Loyalitas Pelangan dengan P 0,152>0,05 dan t. hitung 1.445<t.tabel 1.9839, terdapat pengaruh perceived quality terhadap loyalitas pelangan dengan signifikansi 0.038<0,05 dan t.-hitung 1.998>t-tabel 1.9839, Brand loyalty berpengaruh terhadap loyalitas pelangan dengan tingkat signifikansi 0,026<0,05 dan t. hitung 2.219>t.tabel 1.9839, brans association memengaruhi loyalitas merk dengan tingkat signifikansi 0,00<0,05 dan t hitung 3.699> t.tabel 1.9838, dan <em>Brand Awareness</em>,<em>Brand association, perceived quality, Brand loyalty berpengaruh </em>terhadap loyalitasnasabah Bank Panin Dubai Syariahsignifikansi 0,00<0,05 dan F hitung 7,655> F.tabel 2.700. Benang merah penelitian bahwa; <em>Brand Awareness </em>tidak berpengaruh terhadap loyalitas pelanggan, <em>Brand association, perceived quality, Brand loyalty berpengaruh </em>terhadap loyalitas nasabah Bank Panin Dubai Syariah, dan <em>Brand Awareness</em>,<em>Brand association, perceived quality, Brand loyalty berpengaruh secara </em><em>b</em><em>ersama </em>terhadap loyalitas nasabah Bank Panin Dubai Syariah.</p><p> <strong>Kata Kunci :</strong><em> Brand Awareness,Brand association, perceived quality, Brand loyalty</em><em>terhadap loyalitas</em></p>
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Keim. "Chronische Pankreatitis – Pankreaskarzinom: Einfluss genetischer Faktoren". Praxis 94, n.º 20 (1 de mayo de 2005): 811–17. http://dx.doi.org/10.1024/0369-8394.94.20.811.
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Chronische Pankreatitis: In den letzten Jahren wurden bei Patienten mit chronischer Pankreatitis zahlreiche genetische Risikofaktoren beschrieben. Trypsinogenmutationen (N29I, R122H) fanden sich bei autosomal-dominant vererbter chronischer Pankreatitis. Bei der als «idiopathisch» charakterisierten Form liessen sich vor allem Varianten des Trypsininhibitors SPINK1 und dem cystic fibrosis transmembrane conductance regulator (CFTR) nachweisen, der auch bei der Mukoviszidose mutiert ist. SPINK1 und CFTR-Mutanten zeigten sich aber auch bei der alkoholischen Pankreatitis. Insgesamt waren bei 20 bis 25% der Patienten genetische Risikofaktoren nachzuweisen. Die Wertung dieser Faktoren zeigt, dass die genetischen Faktoren ein wesentlich höheres Risiko implizieren, als es der Alkoholkonsum verursacht. Die grössere Häufigkeit der alkoholischen Pankreatitis ist natürlich durch den weit verbreiteten exzessiven Alkoholkonsum bedingt. Eine genetische Untersuchung ist obligat, falls eine Familienanamnese vorliegt bzw. die Manifestation im Kindesalter erfolgt. Mutationen lassen sich allerdings auch bei vielen Patienten mit Manifestation im höheren Lebensalter nachweisen.Pankreaskarzinom: Das Pankreaskarzinom tritt in 10% der Fälle familiär auf, allerdings ist nur bei einem geringen Anteil ein genetischer Faktor nachzuweisen. Patienten mit Pankreaskarzinom und HNPCC, Peutz-Jeghers oder hereditärer Pankreatitis sind eine ausserordentliche Rarität. Hier wurde ein (bisher nicht evaluiertes) Screeningprogramm vorgeschlagen. Das PanIN-Konzept (pankreatische intraepitheliale Neoplasie) ist der Adenom-Karzinom-Sequenz beim Kolonkarzinom ähnlich, mit dem die Entwicklung des Tumors aus den Vorstufen erklärt wird. Die morphologischen Veränderungen sind Epithelzellhyperplasien (PanIN 1A), papilläre Hyperplasien mit und ohne Atypien (PanIN 1B, 2) und das Carcinoma in situ (PanIN 3). Diese sind mit genetischen Alterationen assoziiert (z.B. ki-ras, p16, p53 etc.) und haben Störungen der Zellzyklusregulation und der Apoptose zur Folge. Bereits im präklinischen Stadium des Carcinoma in situ (PanIN 3) handelt es sich um ein genetisch weit fortgeschrittenes Tumorleiden. Mit den Erkenntnissen aus den molekularbiologischen Forschungen können neue Therapiestrategien entwickelt werden. Angesichts der extrem ungünstigen Prognose der Erkrankung wären auch kleine Fortschritte in der Therapie ausserordentlich hilfreich.Sowohl bei der chronischen Pankreatitis als auch beim Pankreaskarzinom haben die Beschreibung von genetischen Risiko- oder Progressionsfaktoren zu einem wichtigen Fortschritt im Verständnis der Pathogenese der Erkrankungen gebracht. Beim Pankreaskarzinom hat dies bereits einen (begrenzten) Eingang in die Therapie gefunden.
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Jung, Jung Hwa, Danuta Sosnowska, Jessica Weaver, Henri K. Parson, Carolina M. Casellini y Aaron I. Vinik. "Expression of Hypoxia-Inducible Factors in Different Stages of Pancreatic Tumor Progression". Reports 3, n.º 4 (15 de octubre de 2020): 30. http://dx.doi.org/10.3390/reports3040030.
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Background: Early diagnosis in pancreatic cancer is key for improving prognosis. Hypoxia plays a critical role in tumor progression. Thus, an evaluation of associations between pancreatic tumor progression and markers of hypoxia is needed. Methods: We assessed the expression of hypoxia-inducible factors (HIF-1α and HIF-2α) by immuno-histochemical staining from 29 subjects with the following: pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasm (IPMN), neuroendocrine tumor (NET), and pancreatic ductal adenocarcinoma (PDAC) and compared it to the expression in non-tumor samples. Results: Expression of HIF-1α increased significantly from PanIN (3.01 ± 0.17) to IPMN (7.63 ± 0.18), NET (9.10 ± 0.23) and PDAC samples (11.06 ± 0.15, p < 0.0001). Similar findings were observed for HIF-2α (p < 0.0001)}. A strong correlation between HIF-1α and HIF-2α expression was demonstrated (R2 = 0.8408, p < 0.0001). Conclusions: This data suggest that HIF-1α and HIF-2α may play a role in the progression from PanIN through PDAC. Further studies are necessary to confirm these findings and determine the effect of HIFs abrogation on tumor progression that can lead to novel therapies.
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Chen, Shan-Ming, Li-Jin Hsu, Hsiang-Lin Lee, Ching-Pin Lin, Szu-Wei Huang, Caucasus Jun-Lin Lai, Chia-Wei Lin et al. "Lactobacillus Attenuate the Progression of Pancreatic Cancer Promoted by Porphyromonas Gingivalis in K-rasG12D Transgenic Mice". Cancers 12, n.º 12 (26 de noviembre de 2020): 3522. http://dx.doi.org/10.3390/cancers12123522.
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Accumulating evidence suggests that there is a link between the host microbiome and pancreatic carcinogenesis, and that Porphyromonas gingivalis (P. gingivalis) increases the risk of developing pancreatic cancer. The aim of the current study was to clarify the role of P. gingivalis in the pathogenesis of pancreatic cancer and the potential immune modulatory effects of probiotics. The six-week-old LSL-K-rasG12D; Pdx-1-cre (KC) mice smeared P. gingivalis on the gums, causing pancreatic intraepithelial neoplasia (PanIN) after four weeks to be similar to the extent of lesions in untreated KC mice at 24 weeks. The oral inoculation of P. gingivalis of six-week-old LSL-K-rasG12D; Pdx-1-cre (KC) mice caused significantly pancreatic intraepithelial neoplasia (PanIN) after treatment four weeks is similar to the extent of lesions in untreated KC mice at 24 weeks. The pancreas weights of P. gingivalis plus probiotic-treated mice were significantly lower than the mice treated with P. gingivalis alone (P = 0.0028). The histological expressions of Snail-1, ZEB-1, collagen fibers, Galectin-3, and PD-L1 staining in the pancreas were also notably lower. In addition, probiotic administration reduced the histological expression of Smad3 and phosphorylated Smad3 in P. gingivalis treated KC mice. We demonstrated that oral exposure to P. gingivalis can accelerate the development of PanIN lesions. Probiotics are likely to have a beneficial effect by reducing cancer cell proliferation and viability, inhibiting PanIN progression, and cancer cell metastasis (Epithelial–mesenchymal transition, EMT). The transforming growth factor-β signaling pathway may be involved in the tumor suppressive effects of probiotics.
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Neshitov, Alexander. "FRAMED CORRESPONDENCES AND THE MILNOR–WITT -THEORY". Journal of the Institute of Mathematics of Jussieu 17, n.º 4 (30 de junio de 2016): 823–52. http://dx.doi.org/10.1017/s1474748016000190.
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Given a field $k$ of characteristic zero and $n\geqslant 0$, we prove that $H_{0}(\mathbb{Z}F(\unicode[STIX]{x1D6E5}_{k}^{\bullet },\mathbb{G}_{m}^{\wedge n}))=K_{n}^{MW}(k)$, where $\mathbb{Z}F_{\ast }(k)$ is the category of linear framed correspondences of algebraic $k$-varieties, introduced by Garkusha and Panin [The triangulated category of linear framed motives $DM_{fr}^{eff}(k)$, in preparation] (see [Garkusha and Panin, Framed motives of algebraic varieties (after V. Voevodsky), Preprint, 2014, arXiv:1409.4372], § 7 as well), and $K_{\ast }^{MW}(k)$ is the Milnor–Witt $K$-theory of the base field $k$.
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Saloman, Jami L., Kathryn M. Albers, Dongjun Li, Douglas J. Hartman, Howard C. Crawford, Emily A. Muha, Andrew D. Rhim y Brian M. Davis. "Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer". Proceedings of the National Academy of Sciences 113, n.º 11 (29 de febrero de 2016): 3078–83. http://dx.doi.org/10.1073/pnas.1512603113.
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Pancreatic ductal adenocarcinoma (PDAC) is characterized by an exuberant inflammatory desmoplastic response. The PDAC microenvironment is complex, containing both pro- and antitumorigenic elements, and remains to be fully characterized. Here, we show that sensory neurons, an under-studied cohort of the pancreas tumor stroma, play a significant role in the initiation and progression of the early stages of PDAC. Using a well-established autochthonous model of PDAC (PKC), we show that inflammation and neuronal damage in the peripheral and central nervous system (CNS) occurs as early as the pancreatic intraepithelial neoplasia (PanIN) 2 stage. Also at the PanIN2 stage, pancreas acinar-derived cells frequently invade along sensory neurons into the spinal cord and migrate caudally to the lower thoracic and upper lumbar regions. Sensory neuron ablation by neonatal capsaicin injection prevented perineural invasion (PNI), astrocyte activation, and neuronal damage, suggesting that sensory neurons convey inflammatory signals from Kras-induced pancreatic neoplasia to the CNS. Neuron ablation in PKC mice also significantly delayed PanIN formation and ultimately prolonged survival compared with vehicle-treated controls (median survival, 7.8 vs. 4.5 mo;P= 0.001). These data establish a reciprocal signaling loop between the pancreas and nervous system, including the CNS, that supports inflammation associated with oncogenic Kras-induced neoplasia. Thus, pancreatic sensory neurons comprise an important stromal cell population that supports the initiation and progression of PDAC and may represent a potential target for prevention in high-risk populations.
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Daga, Rosnaini. "The Influence of Credit Period and Interest Rates on the Interest of Home Ownership Credit Users in PT. PANIN Bank (PERSERO) TBK". Information Management and Business Review 8, n.º 2 (7 de junio de 2016): 54–62. http://dx.doi.org/10.22610/imbr.v8i2.1273.
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This study aims to examine the influence of credit period and interest rates on mortgages users’ interest in PT. Panin Bank (Persero) Tbk. The method used in this research is multiple linear regression analysis using SPSS, which was processed based on the tabulated results of the observation sheet. From the analysis of the influence of credit period and interest rates on mortgages users’ interest in PT. Panin Bank (Persero) Tbk. Makassar branch, it can be concluded that the term and interest rates have a positive effect on mortgages users’ interest in the bank. The increase of the time limit will also increase the interests of customers. On the other hand, the increase of interest rates will decrease the interest of users. From these two researched variables, the most dominant variable affecting the mortgages users’ interest in PT. Panin Bank (Persero) Tbk. Makassar branch is interest rates, because interest rates have the greatest t-count compared to the t-count of credit period. Therefore, it can be proposed that one of the most dominant variables affecting the interest of the mortgages users in the bank is the interest rates.
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Guspendri, Nasfizar y Revi Candra. "Pengaruh Pembiayaan dan Ukuran Perusahaan terhadap Profitabilitas (ROA) pada PT Bank Panin Dubai Syariah Tbk". Jurnal Pasar Modal dan Bisnis 2, n.º 1 (30 de abril de 2020): 1–12. http://dx.doi.org/10.37194/jpmb.v2i1.36.
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Tujuan penelitian ini adalah untuk menjelaskan seberapa besar pengaruh pembiayaan dan ukuran perusahaan terhadap profitabilitas pada PT. Bank Panin Dubai Syariah Tbk. Jenis penelitian yang penulis gunakan adalah penelitian deskriptif kuantitatif yaitu pada PT. Bank Panin Dubai Syariah Tbk. Sumber data penelitian ini menggunakan data yang diperoleh dari Bursa Efek Indonesia dan Otoritas Jasa Keuangan (OJK) yaitu berupa data sekunder dalam bentuk laporan keuangan triwulan PT. Bank Panin Dubai Syariah Tbk. Teknik pengumpulan data yakni dokumentasi berupa laporan keuangan triwulan yang dipublikasikan. Uji data yang digunakan adalah analisis asumsi klasik dan goodness of fit dengan uji F. Analisa data menggunakan analisis regresi linear berganda, uji T-tes, dan uji koefisien determinasi. Pengolahan data menggunakan Statistical Product and Service Solution (SPSS) IBM version 22.
Hasil penelitian ini menunjukkan bahwa pembiayaan berpengaruh terhadap ROA, pembiayaan berpengaruh terhadap ukuran perusahaan. Ukuran perusahaan berpengaruh terhadap ROA. Ukuran perusahaan pada penelitian ini tidak efektif berperan sebagai variabel perantara antara variabel pembiayaan terhadap ROA karena variabel pembiayaan menghasilkan koefesien negatif terhadap ukuran perusahaan dan variabel ukuran perusahaan juga berpengaruh negatif terhadap ROA. Disimpulkan bahwa H4 di tolak. Koefesian determinan menunjukan bahwa secara simultan pembiayaan dan ukuran perusahaan berpengaruh terhadap ROA.
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Rusydiana, Aam y Salman Al Parisi. "The Measurement of Islamic Bank Performance: A Study Using Maqasid Index and Profitability". Global Review of Islamic Economics and Business 4, n.º 1 (8 de diciembre de 2016): 001. http://dx.doi.org/10.14421/grieb.2016.041-01.
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This study aims to 1) measure Syariah Maqasid Index (SMI) and Profitability Index (PI) of Islamic Banks, and 2) compare the Syariah Maqasid and Profitability Index of Islamic Banks during 2011-2014 with cartesian diagram. This research consists of 2 methods: syariah maqasid index weighting (sekaran method), and Comparative Performance Index (CPI). The object of research consist of 11 Islamic Banks (BUS) in Indonesia with annual data 2011 to 2014. Result: Syariah Maqasid Index of BUS during 2011-2014 from the highest to the lowest, namely Panin Syariah (0254), BCAS (0212), BMI (0208), BRIS (0207), BSM (0202), BSB (0.2008), BJBS ( 0.2006), Victoria Syariah (0199), Maybank Syariah (0197), BNIS (0195), Mega Syariah Bank (0172). Then Profitability Index of BUS in 2011-2014 from the highest to the lowest, namely Maybank Syariah (628.5), Bank Mega Syariah (472.1), BSM (459.9), Panin Syariah (395.5), Victoria Sharia (355.4), BNIS (252.6), BMI (218.2), BCAS (155.4), BSB (150.9), BRIS (135.3), and BJBS (122.3). Conclusion: The highest of Syariah Maqasid Index is Panin Syariah Bank in period 2011-2014, while the highest of Profitability Index is Maybank Syariah in period 2011-2014.
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Naito, Yoshiki, Naofumi Eriguchi, Tohru Kume, Masayasu Naito, Mitsuhiro Nishimura, Masayo Ohdo, Noriaki Itai et al. "Multi-centric pancreatic cancer without PanIN lesion". Journal of Hepato-Biliary-Pancreatic Surgery 16, n.º 5 (31 de marzo de 2009): 699–703. http://dx.doi.org/10.1007/s00534-009-0065-y.
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Cornea, Remus, Sorina Taban, Cristian Suciu, Codruta Lazureanu y Alis Dema. "Intestinal Heterotopic Pancreas Involved by Simultaneous PanIN-2 Lesion and Endocrine Microadenoma: a Unique Case". Journal of Gastrointestinal and Liver Diseases 26, n.º 2 (1 de junio de 2017): 199–202. http://dx.doi.org/10.15403/jgld.2014.1121.262.pan.
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We hereby present the case of a 58-year-old male who underwent a total gastrectomy for gastric neoplasm. During the surgery, a tumor mass in the jejunum was identified, considered as metastasis, and resected. The histopathological examination of the jejunal lesion showed ectopic pancreas. In this area, two pathological distinct lesions were identified, one histologically compatible with pancreatic intraepithelial neoplasia (PanIN) type 2 lesion and the other with morphologic criteria for endocrine microadenoma. To our knowledge, this is the first case that evidences the presence of a concomitant premalignant exocrine lesion and benign endocrine lesion in a heterotopic pancreas (HP).Abbreviations: HP: heterotopic pancreas; IPMN: Intraductal Papillary Mucinous Neoplasms; PanIN: Pancreatic Intraepithelial Neoplasia; PEN: pancreatic endocrine neoplasm.
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Distler, M., D. Aust, J. Weitz, C. Pilarsky y Robert Grützmann. "Precursor Lesions for Sporadic Pancreatic Cancer: PanIN, IPMN, and MCN". BioMed Research International 2014 (2014): 1–11. http://dx.doi.org/10.1155/2014/474905.
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Pancreatic cancer is still a dismal disease. The high mortality rate is mainly caused by the lack of highly sensitive and specific diagnostic tools, and most of the patients are diagnosed in an advanced and incurable stage. Knowledge about precursor lesions for pancreatic cancer has grown significantly over the last decade, and nowadays we know that mainly three lesions (PanIN, and IPMN, MCN) are responsible for the development of pancreatic cancer. The early detection of these lesions is still challenging but provides the chance to cure patients before they might get an invasive pancreatic carcinoma. This paper focuses on PanIN, IPMN, and MCN lesions and reviews the current level of knowledge and clinical measures.
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Li, Junsheng, Jörg Kleeff, Irene Esposito, Hany Kayed, Klaus Felix, Thomas Giese, Markus W. Büchler y Helmut Friess. "Expression Analysis of PMP22/Gas3 in Premalignant and Malignant Pancreatic Lesions". Journal of Histochemistry & Cytochemistry 53, n.º 7 (julio de 2005): 885–93. http://dx.doi.org/10.1369/jhc.4a6546.2005.
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PMP22 is a structural protein of Schwann cells, but it also influences cell proliferation. In the present study, quantitative RT-PCR (QRT-PCR) and immunohistochemistry were used to determine PMP22 mRNA levels and to localize PMP22 in the normal pancreas ( n=20), chronic pancreatitis (CP) ( n=22), pancreatic ductal adenocarcinoma (PDAC) ( n=31), intraductal papillary mucinous neoplasms (IPMN) ( n=9), mucinous cystic tumors (MCN) ( n=4), and in a panel of PanIN lesions ( n=29). PMP22 mRNA levels were significantly higher in CP (3-fold) and PDAC (2.5-fold), compared to normal pancreatic tissues. PMP22 expression was restricted to nerves in the normal pancreas, while in CP and PDAC PMP22 was also expressed in PanIN lesions and in a small percentage of pancreatic cancer cells. PMP22 was weak to absent in the tumor cells of IPMNs and MCNs. PMP22 mRNA was present at different levels in cultured pancreatic cancer cells and up-regulated by transforming growth factor (TGF)-β1 in 2 of 8 of these cell lines. In conclusion, PMP22 expression is present in both CP and PDAC tissues. Its expression in PanIN lesions and some pancreatic cancer cells in vitro and in vivo suggests a role of PMP22 in the neoplastic transformation process from the normal pancreas to pre-malignant lesions to pancreatic cancer.
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Verianto, Hery. "Pengaruh Kepercayaan, Efikasi diri, dan Komitmen Organisasional terhadap Berbagi Pengetahuan Karyawan di Kantor Cabang Utama PT Bank Panin Tbk Kota Pontianak". Jurnal Ekonomi Bisnis dan Kewirausahaan 8, n.º 2 (29 de agosto de 2019): 128. http://dx.doi.org/10.26418/jebik.v8i2.27540.
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This research aims at examining and analyzing the influence of trust, self-efficacy, and organizational commitment on employees’ knowledge sharing at The Main Office of PT Bank Panin Tbk Kota Pontianak. Research method applied is causal approach survey in form of quantitative causal decription. Census technic is used to collect the primary data. A Total of 70 questionnaires were distributed among the employees. Collectively, 51 usable questionnaires were returned. Secondary data was elicited from interviewing Main Branch Office Manager and website of PT Bank Panin Tbk. Analytical technique used is path analysis. The result of the research shows that trust influences organizational commitment but does not influence employees’ knowledge sharing. Self-efficacy influences organizational commitment and employees’ knowledge sharing. Organizational commitment does not influence employees’ knowledge sharing.
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Daryanto, Wiwiek Mardawiyah. "Comparison of Financial Performance Buku III Indonesian Banks Using Risk-Based Bank Rating (RBBR) Method: Case Study of PT. Pan Indonesia Bank, Tbk (Panin) and PT. Bank Mega, Tbk (Mega)". International Journal of Business Studies 4, n.º 1 (2 de marzo de 2020): 37–45. http://dx.doi.org/10.32924/ijbs.v4i1.139.
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Indonesia has experienced economic crisis in 1997/1998 and 2008, these events motivate the government to have a strong assessment to evaluate the financial health of the company. Related to the banks industry, government of Indonesia through Financial Service Authority or Otoritas Jasa Keuangan (OJK) issued the Circular Letter of OJK No. 14/SEOJK.03/2017 about Risk-Based Bank Rating (RBBR) approach that include the evaluation of risk profile, good corporate governance, earnings, and capital. The purpose of this study is to assess the financial health of the two open recorded non-expressed claimed BUKU III banks in Indonesia, which are Bank PT. Pan Indonesia Bank, Tbk (Panin) and PT. Bank Mega, Tbk (Mega) from year of 2014 to 2018. The methodology used is RBBR approach concerning the Rating of Health of Commercial Banks. The data were collected from the yearly report of the banks, fiscal reports, diaries, and articles of PT. Bank Mega and PT. Bank Panin. During the five year trend, the result of this study reveals that the two banks have performed well. However, Bank Mega has performed better in terms of Loan to Deposit Ratio (LDR) compared to Bank Panin. This study has added the knowledge in the financial literature. It also brings benefit for managers to help them make a better decision to address their company’s problem.
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Sholichah, Dhevy Ulinnuha y Dian Filianti. "ANALISA CAPITAL ADEQUACY RATIO (CAR), RETURN ON ASSET (ROA), NON PERFORMING FINANCING (NPF), DAN FINANCING TO DEPOSIT RATIO (FDR) BANK PANIN DUBAI SYARIAH SEBELUM DAN SESUDAH IPO PERIODE 2011-2017". Jurnal Ekonomi Syariah Teori dan Terapan 6, n.º 2 (22 de enero de 2020): 228. http://dx.doi.org/10.20473/vol6iss20192pp228-242.
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This research analyzed the difference between sharia bank’s financial performance before and after IPO period 2011-2017. Common Sharia Bank that match the criteria is Panin Dubai Syariah Bank. Data used in this research is secondary data that collected from bank’s annual financial statements. Financial ratios used as variables in this research are Capital Adequacy Ratio (CAR), Non Performing Financing (NPF), Return On Assets (ROA), and Financing to Deposit Ratio (FDR). The results that tested using Paired T-Test and Wilcoxon Signed Rank Test shows that CAR, NPF, ROA, and FDR on Panin Dubai Syariah Bank indicate there’s significantly difference between before and after IPO. The significantly differences indicated using significance levels of 1%, 5%, and 10%.Keywords: Sharia Bank, Financial Performance, CAR, NPF, ROA, FDR, Initial Public Offering
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Stiawan, Evan y Vivi Esty Magfiroh. "Pengukuran Kinerja Keuangan PT Bank Panin Dubai Syariah Tbk Menggunakan Model Analisis DuPont System". Telaah Bisnis 21, n.º 1 (16 de abril de 2021): 47. http://dx.doi.org/10.35917/tb.v21i1.212.
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The purpose of this study is to study and compare financials for each financial period for three periods from PT Bank Panin Dubai Syariah Tbk. Period 2016-2018. The company’s financial performance uses Return on Equity (ROE), Return on Investment (ROI), Total Asset Turnover (TAT), and Net Profit Margin (NPM). This study uses a comparative quantitative method using secondary data sources, namely the source of PT Bank Panin Dubai Syariah Tbk’s financial reports since 2009. The research sample consisted of 12 financial statements selected by purposive sampling with a total of 48 data, and data analysis techniques using Two Ways ANOVA. The analysis showed a significant difference between finances based on the category of financial ratios over the three periods known from the significant value of 0,000<0.05.
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Madriles, Francesc, Irene Espósito, Paola Martinelli y Francisco X. Real. "PanIN-less PDAC: See it to believe it". Pancreatology 15, n.º 3 (junio de 2015): S31. http://dx.doi.org/10.1016/j.pan.2015.05.140.
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Silva, Marco, Rosa Coelho, Pedro Moutinho-Ribeiro, Rui Gaspar, Patrícia Andrade, Pedro Costa-Moreira, Ana Luísa Santos et al. "Pancreatic intraepithelial neoplasia (PanIN) in resected pancreatic cancer". Pancreatology 17, n.º 3 (julio de 2017): S85. http://dx.doi.org/10.1016/j.pan.2017.05.269.
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He, Xiaojun, Hui Zhang, Mei Xiao, Yalin Kong, Wenbing Li y Hongyi Zhang. "Inhibition of progression of PanIN through antagonizing EGFR". Tumor Biology 36, n.º 5 (18 de diciembre de 2014): 3245–49. http://dx.doi.org/10.1007/s13277-014-2953-2.
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