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Tesis sobre el tema "Pharmacokinetic interactions"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 25 de julio de 2025

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1

McArdle, Elizabeth Karen. "Pharmacokinetic interactions of constituents of cannabis extracts." Thesis, University of Aberdeen, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415480.

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The use of a whole plant cannabis extract, containing <span style='font-family:Symbol'>D<sup>9</sup>-tetrahydrocannabinol (THC) and cannabidiol (CBD) as the principal constituents, showed statistically significant improvements in the management of multiple sclerosis. Inhibition studies (e.g. IC<sub>50</sub> and K<sub>i</sub> determinations) using phenotyped human liver microsomes and cDNA expressed human P450s (Supersomes<span style='font-family:Symbol'>â demonstrated that CBD competitively inhibits the principal P450s involved in the THC biotransformation, CYP2C9 (K<sub>i</sub> = 0.5 <span st

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2

Raaska, Kari. "Pharmacokinetic interactions of clozapine in hospitalized patients." Helsinki : University of Helsinki, 2003. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/raaska/.

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3

Lundahl, Anna. "In vivo Pharmacokinetic Interactions of Finasteride and Identification of Novel Metabolites." Doctoral thesis, Uppsala universitet, Institutionen för farmaci, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-129362.

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The general aim of this thesis was to improve the understanding of the in vivo pharmacokinetics and, in particular, the metabolism of finasteride, a 5α-reductase inhibitor used in the treatment of enlarged prostate glands and male pattern baldness. CYP3A4 has been identified as the major enzyme involved in the sequential metabolism of finasteride to ω-OH finasteride (M1) and ω-COOH finasteride (M3). The consequences of induced and inhibited metabolism on the pharmacokinetics of finasteride and its metabolites were investigated in humans and pigs. Both studies included bile collection. The coll

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4

Adedoyin, A. P. "Pharmacokinetic drug-drug interactions : inhibition and induction studies in the rat." Thesis, University of Manchester, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376236.

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5

Elsherbiny, Doaa. "Pharmacokinetic drug-drug interactions in the management of malaria, HIV and tuberculosis." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8426.

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6

Yadav, Jaydeep. "EVALUATING PHARMACOKINETIC DRUG-DRUG INTERACTIONS DUE TO TIME DEPENDENT INHIBITION OF CYTOCHROME P450s." Diss., Temple University Libraries, 2018. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/524248.

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Pharmaceutical Sciences<br>Ph.D.<br>Time-dependent inactivation (TDI) of CYPs is a leading cause of clinical drug-drug interactions (DDIs). Current methods tend to over-predict DDIs. In this study, a numerical approach was used to model complex CYP3A TDI in human liver microsomes. Inhibitors evaluated include troleandomycin (TAO), erythromycin (ERY), verapamil (VER), Paroxetine (PAR), itraconazole (ITZ) and diltiazem (DTZ) along with primary metabolites N-demethyl erythromycin (NDE), norverapamil (NV), and N-desmethyl diltiazem (MA). Complexities incorporated in the models included multiple bi

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7

Cherkaoui, Rbati Mohammed. "Mathematical and physical systems biology : application to pharmacokinetic drug-drug interactions and tumour growth." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/33719/.

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In this thesis, a multi-scale approach is provided to a pharmacokinetic and a pharmacodynamic problem. The first part of this research provides a realistic mathematical physiological model of the liver to predict drug drug interactions (DDIs). The model describes the geometry of a lobule (liver unit) and integrates the exchange processes, diffusion and active transport, between the hepatocytes and the blood and possible drug-drug interactions such as; reversible inhibition, mechanistic based inhibition (MBI) and enzyme induction. The liver model is subsequently integrated into a PBPK model wit

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8

Naghmeh, Jabarizadekivi. "A Comparison of the Effect of Omeprazole and Rabeprazole on Clozapine Serum Concentrations." University of Sydney, 2008. http://hdl.handle.net/2123/2471.

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Master of Philosophy<br>Clozapine is a drug of choice for treatment of refractory schizophrenia, which is primarily metabolized by Cytochrome P450 1A2 (CYP1A2). Norclozapine is its main metabolite. There are reports of wide ranging gastrointestinal side effects associated with clozapine therapy, that result in concomitant administration of proton pump inhibitors to treat acid-related disorders. Omeprazole is an established CYP1A2 inducer, while an in vitro study has shown that rabeprazole is much less potent in this regard. There is no available information about the impact of rabeprazole on C

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9

Naghmeh, Jabarizadekivi. "A Comparison of the Effect of Omeprazole and Rabeprazole on Clozapine Serum Concentrations." Thesis, The University of Sydney, 2007. http://hdl.handle.net/2123/2471.

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Clozapine is a drug of choice for treatment of refractory schizophrenia, which is primarily metabolized by Cytochrome P450 1A2 (CYP1A2). Norclozapine is its main metabolite. There are reports of wide ranging gastrointestinal side effects associated with clozapine therapy, that result in concomitant administration of proton pump inhibitors to treat acid-related disorders. Omeprazole is an established CYP1A2 inducer, while an in vitro study has shown that rabeprazole is much less potent in this regard. There is no available information about the impact of rabeprazole on CYP1A2 activity in patien

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10

Salem, Farzaneh. "Applications of physiologically based pharmacokinetic modelling to prediction of the likelihood of metabolic drug interactions in paediatric population and studying disparities in pharmacokinetics between children and adults." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/applications-of-physiologically-based-pharmacokinetic-modelling-to-prediction-of-the-likelihood-of-metabolic-drug-interactions-in-paediatric-population-and-studying-disparities-in-pharmacokinetics-between-children-and-adults(1fdefe9a-037a-4738-b92a-5904a60960db).html.

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Anticipation of drug-drug interactions (DDIs) in the paediatric population are merely based on data generated in adults. Hence decision on avoiding certain combinations or attempts to adjust and manage the doses under combination-therapy are mainly speculative from the knowledge of what occurs in adults. However, due to developmental changes in elimination pathways from birth to adolescents, the assumption of DDIs being similar in adults and children might not be correct. This thesis firstly identifies and quantitatively compares the reported DDIs in paediatric and adult populations through a

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11

Sall, Carolina. "In vitro-in vivo assessment of repaglinide metabolism and drug-drug interactions : towards a physiologically-based pharmacokinetic model." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/in-vitroin-vivo-assessment-of-repaglinide-metabolism-and-drugdrug-interactionstowards-a-physiologicallybased-pharmacokinetic-model(1b8eca49-bc68-484e-b921-2e324b4c5f00).html.

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Repaglinide is currently recommended as an in vivo CYP2C8 probe by the U.S. Food and Drug Administration (FDA), but the kinetic characterisation and enzymes involved in the elimination of this drug have not been fully delineated. In addition to its complex metabolism, polymorphism in the SLCO1B1 gene encoding for the hepatic uptake transporter organic anion transporting polypeptide 1B1 (OATP1B1) has been shown to impact repaglinide pharmacokinetics, further complicating the prediction of repaglinide clearance and drug-drug interactions (DDIs). The aim of this thesis was to firstly perform a sy

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12

Samineni, Divya. "Pre-Clinical and Clinical Investigation of Pharmacokinetic and Pharmacodynamic Interactions between Darunavir, a Novel Protease Inhibitor and Rosuvastatin." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1314040722.

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13

Pinto, Marta Cruz Batista. "Interações medicamentosas relevantes no tratamento de doenças cardiovasculares." Master's thesis, [s.n.], 2014. http://hdl.handle.net/10284/4519.

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Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas<br>Os doentes cardiovasculares constituem um dos principais grupos de risco no que respeita à ocorrência de interações medicamentosas, não só pela combinação de fármacos usada no tratamento destas doenças como pelo facto de muitos indivíduos sofrerem igualmente de outras patologias que requerem medicação. A interação medicamentosa consiste na alteração da atividade farmacológica de um fármaco provocada pela administração anterior o

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14

Arora, Priyanka. "Pharmacokinetic- Pharmacodynamic Investigations of Letrozole, a Potential Novel Agent for the Treatment of High-Grade Gliomas." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1552398989110981.

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15

Darwich, Adam Saed. "Physiologically-based pharmacokinetic modelling and simulation of oral drug bioavailability : focus on bariatric surgery patients and mechanism-based inhibition of gut wall metabolism." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/physiologicallybased-pharmacokinetic-modelling-and-simulation-of-oral-drug-bioavailability-focus-on-bariatric-surgery-patients-and-mechanismbased-inhibition-of-gut-wall-metabolism(182c1e87-670c-4430-82ba-b335f6c13887).html.

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Understanding the processes that govern pre-systemic drug absorption and elimination is of high importance in pharmaceutical research and development, and clinical pharmacotherapy, as the oral route remains the most frequently used route of drug administration. The emergence of systems pharmacology has enabled the utilisation of in silico physiologically-based pharmacokinetic (PBPK) modelling and simulation (M&S) coupled to in vitro-in vivo extrapolation in order to perform extrapolation and exploratory M&S in special populations and scenarios were concerns regarding alterations in oral drug e

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16

Wiebe, Sabrina [Verfasser], and Gerd [Akademischer Betreuer] Mikus. "Midazolam Microdosing and Population Pharmacokinetic Modelling to Assess CYP3A Drug-Drug Interactions in Early Clinical Development / Sabrina Wiebe ; Betreuer: Gerd Mikus." Heidelberg : Universitätsbibliothek Heidelberg, 2021. http://d-nb.info/1229941436/34.

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17

Wojtyniak, Jan-Georg [Verfasser]. "Model Informed Drug Development and Precision Dosing for Drug-Drug-Gene-Interactions : Application of Physiologically-Based Pharmacokinetic Modeling / Jan-Georg Wojtyniak." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2021. http://d-nb.info/1237268737/34.

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18

Chao, Zhang. "Population pharmacokinetic models describing drug-drug interactions and variability in HIV infected South Africans on protease inhibitor-based antiretroviral regimens with and without tuberculosis." Doctoral thesis, University of Cape Town, 2012. http://hdl.handle.net/11427/3372.

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Includes abstract.<br>Includes bibliographical references.<br>Lopinavir/ritonavir is an important component of the first-line and second-line antiretroviral treatment for young children and adults respectively in the current World Health Organization guidelines. Rifampicin, a key component of antituberculosis treatment, profoundly reduces lopinavir concentrations. Therefore, investigation of the optimal dosage regimens of lopinavir/ritonavir when co-administered with rifampicin-based antituberculosis treatment is needed urgently. Moreover, treatment adherence is associated with virological and

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19

Lê, Minh. "L'apport de l'évaluation pharmacocinétique dans le choix des antirétroviraux (nature et dose) chez la personne vivant avec le VIH." Thesis, Sorbonne Paris Cité, 2019. http://www.theses.fr/2019USPCC020.

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En dépit des récentes avancées thérapeutiques, l’infection par le VIH pour être contrôlée nécessite le maintien à vie d’un traitement antirétroviral (ARV). De ce fait, des stratégies d’allègements destinées à réduire la « charge chimique » sont proposées afin de maintenir l’efficacité antivirale tout en améliorant le profil de tolérance. Les compartiments profonds tels que le compartiment central ou le tractus génital se révèlent des sanctuaires de réplication virale et nécessitent pour son contrôle, une pénétration optimisée des ARV depuis la circulation générale. Nous avons d’abord évalué la

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20

Penson, Richard Thomas. "The morphine glucuronides : pharmacokinetics, pharmacodynamics and interactions." Thesis, Queen Mary, University of London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406201.

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21

Liu, Zhongqiu. "Mechanism of pharmacokinetic interaction between paeoniflorin and sinomenine." HKBU Institutional Repository, 2006. http://repository.hkbu.edu.hk/etd_ra/720.

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22

Li, Mengyao. "USING SEMIPHYSIOLOGICALLY-BASED PHARMACOKINETIC (SEMI-PBPK) MODELING TO EXPLORE THE IMPACT OF DIFFERENCES BETWEEN THE INTRAVENOUS (IV) AND ORAL (PO) ROUTE OF ADMINISTRATION ON THE MAGNITUDE AND TIME COURSE OF CYP3A-MEDIATED METABOLIC DRUG-DRUG INTERACTIONS (DDI) USING MIDAZOLAM (MDZ) AS PROTOTYPICAL SUBSTRATE AND FLUCONAZOLE (FLZ) AND ERYTHROMYCIN (ERY) AS PROTOTYPICAL INHIBITORS." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4402.

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The purpose of the project was to investigate the impact of IV and PO routes difference for MDZ, a prototypical CYP3A substrate, and two CYP3A inhibitors (CYP3AI) -FLZ and ERY-, on the magnitude and time course of their inhibitory metabolic DDI. Individual semi-PBPK models for MDZ, FLZ and ERY were developed and validated separately, using pharmacokinetic (PK) parameters from clinical/in-vitro studies and published physiological parameters. Subsequently, DDI sub-models between MDZ and CYP3AIs incorporated non-competitive and mechanism-based inhibition (MBI) for FLZ and ERY, respectively, on he

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23

Bouwer, Máralien. "The pharmacokinetic interaction between cyclosporine and methoxsalen / Máralien Bouwer." Thesis, North-West University, 2003. http://hdl.handle.net/10394/331.

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Cyclosporine forms the cornerstone of therapy to prevent rejection after organ transplantation. However, the clinical use of the drug is compromised by a narrow therapeutic window and a wide inter- and intra-individual variation in metabolism. Cyclosporine is metabolised by the CYP3A4 isoenzymes in both the liver and intestine, while it has been reported that the metabolism of the drug can be inhibited by certain furocoumarin derivatives in grapefruit juice. Methoxsalen (8-methoxypsoralen) is a furocoumarin and a potent inhibitor of the cytochrome P450 system in both the liver and intestine. T

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24

Muggli, Franco. "Pharmacokinetic and pharmacodynamic interaction between furosemide and metolazone in man /." [S.l : s.n.], 1986. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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25

Abebe, Bayew Tsega [Verfasser], Werner [Akademischer Betreuer] Siegmund, Siegmund [Gutachter] Werner, and Hartmut [Gutachter] Derendorf. "In Vitro to In Vivo Extrapolation of Pharmacokinetic Drug Interactions between Clarithromycin and Ranitidine with Trospium Chloride to Evaluate Probe Drug Characteristics for P-glycoprotein and Organic Cation Transporter Functions in Human / Bayew Tsega Abebe ; Gutachter: Siegmund Werner, Hartmut Derendorf ; Betreuer: Werner Siegmund." Greifswald : Universität Greifswald, 2020. http://d-nb.info/1203299958/34.

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26

Abebe, Bayew Tsega [Verfasser], Werner Akademischer Betreuer] Siegmund, Siegmund [Gutachter] Werner, and Hartmut [Gutachter] [Derendorf. "In Vitro to In Vivo Extrapolation of Pharmacokinetic Drug Interactions between Clarithromycin and Ranitidine with Trospium Chloride to Evaluate Probe Drug Characteristics for P-glycoprotein and Organic Cation Transporter Functions in Human / Bayew Tsega Abebe ; Gutachter: Siegmund Werner, Hartmut Derendorf ; Betreuer: Werner Siegmund." Greifswald : Universität Greifswald, 2020. http://nbn-resolving.de/urn:nbn:de:gbv:9-opus-34845.

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27

Sjögren, Erik. "Hepatic Disposition of Drugs and the Utility of Mechanistic Modelling and Simulation." Doctoral thesis, Uppsala universitet, Institutionen för farmaci, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-132571.

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The elimination of drugs from the body is in many cases performed by the liver. Much could be gained if an accurate prediction of this process could be made early in the development of new drugs. However, for the elimination to occur, the drug molecule needs first to get inside the liver cell. Disposition is the expression used to encapsulate both elimination and distribution. This thesis presents novel approaches and models based on simple in vitro systems for the investigation of processes involved in the hepatic drug disposition. An approach to the estimation of enzyme kinetics based on su

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28

Parkin, Donald Pysden. "A critical appraisal of the clinical pharmacokinetics of isoniazid." Thesis, Link to the online version, 1996. http://hdl.handle.net/10019.1/1267.

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29

Jokinen, Mika. "Effects of drug interactions and liver disease on the pharmacokinetics of ropivacaine." Helsinki : University of Helsinki, 2003. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/jokinen/.

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30

Kim, Shinja Rhea. "Pharmacokinectic and pharmacodynamic aspects of cocaine and its interaction with ethanol." Diss., The University of Arizona, 1997. http://hdl.handle.net/10150/289511.

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The main purpose of the research described in this dissertation was to evaluate various aspects of cocaine in pharmacokinetics and pharmacodynamics including: physiologically based-pharmacokinetics modeling; the influence of ethanol on cocaine disposition. Further, cocaine and cocaethylene (CE) were compared using pharmacokinetic-pharmacodynamic (PK-PD) models. Lastly, PK-PD models after cocaine and a combination of cocaine and ethanol dose were developed. Cocaine was administered by iv with or without ethanol in rats. CE was formed only in the group of rats given cocaine in the presence of et

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31

Robertson-Dallas, Shannon. "The pharmacokinetic interaction between zidovudine and trimethoprim-sulfamethoxazole in HIV-1 infected children." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0027/MQ40854.pdf.

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32

Chen, Mingqing. "Interactions between multi-kinase inhibitors and solute carrier transporters." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1585741410361704.

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33

Astbury, Carol. "The pharmacokinetics, actions and interactions of suphasalazine in rheumatoid arthritis and inflammatory bowel disease." Thesis, University of Leeds, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328902.

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34

Müller, Adrienne Carmel. "African traditional medicine-antiretroviral interactions : effects of Sutherlandia frutescens on the pharmacokinetics of Atazanavir." Thesis, Rhodes University, 2011. http://hdl.handle.net/10962/d1013373.

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In response to the urgent call for investigations into antiretroviral (ARV)-African traditional medicine (ATM) interactions, this research was undertaken to ascertain whether chronic administration of the ATM, Sutherlandia frutescens (SF) may alter the bioavailability of the protease inhibitor (PI), atazanavir (ATV), which may impact on the safety or efficacy of the ARV. Prior to investigating a potential interaction between ATV and SF in vitro and in vivo, a high performance liquid chromatography method with ultraviolet detection (HPLC-UV) was developed and validated for the bioanalysis of AT

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35

Volz, Anke-Katrin [Verfasser]. "Modelling and simulation techniques to investigate pharmacokinetics, pharmacodynamics, and drug-drug interactions / Anke-Katrin Volz." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2021. http://d-nb.info/1228333696/34.

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36

Kulmatycki, Kenneth M. "Disease-drug interactions, pharmacokinetics and pharmacodynamics of sotalol and lidocaine in the presence of inflammatory conditions." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0012/NQ59615.pdf.

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37

Yeh, Teng-Kuang. "Pharmacokinetics of anti-aids and anti-cancer drugs : implications on drug delivery and drug interaction /." The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu148654688938101.

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38

Jiang, Xuemin. "Effect of herbal medicines on the pharmacokinetics and pharmacodynamics of Warfarin in healthy subjects." University of Sydney. Pharmacy, 2004. http://hdl.handle.net/2123/651.

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Herbal medicines are widely used in our community. A survey of Australian consumers indicated that 60% had used complementary and/or alternative medicines in the past year with the majority not informing their doctor that they were using herbal medicines. Little is known about the potentially serious consequences of interactions between herbal and conventional medicines. Warfarin has an important role in treating people with heart disease, yet it has a narrow therapeutic range, is highly bound to plasma proteins, and is metabolised by cytochrome P450. This creates the potential for life-threat

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39

Fasinu, Pius Sedowhe. "In vitro assessment of some traditional medications used in South Africa for pharmacokinetics drug interaction potential." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/85850.

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Thesis (PhD)--Stellenbosch University, 2013.<br>ENGLISH ABSTRACT: Introduction Earlier studies have shown the popularity of herbal products among people as traditional, complementary or alternative medication. One of the major clinical risks in the concomitant administration of herbal products and prescription medicine is pharmacokinetic herb-drug interaction (HDI). This is brought about by the ability of phytochemicals to inhibit or induce the activity of metabolic enzymes and transport proteins. The aim of this study was to investigate the potential of the crude extracts of popular med

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40

Awortwe, Charles. "Pharmacokinetic herb-drug interaction study of selected traditional medicines used as complementary and alternative medicine (CAM) for HIV/AIDS." Thesis, Stellenbosch : Stellenbosch University, 2015. http://hdl.handle.net/10019.1/96796.

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Thesis (DMed)--Stellenbosch University, 2015<br>ENGLISH ABSTRACT: Introduction The increasing intake of traditional medicines among HIV/AIDS patients in sub-Saharan Africa needs urgent consideration by clinicians and other healthcare providers since the safety of such medications are unknown. The pharmacokinetic parameters - Absorption, Distribution, Metabolism and Elimination (ADME) play important role in the safety evaluation of drugs, thus implicating drug metabolizing enzymes and transporters as critical indicators for herb-drug interactions. The objective of this study was to evaluate th

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41

Chen, Chunli. "Pharmacokinetic-Pharmacodynamic Evaluations and Experimental Design Recommendations for Preclinical Studies of Anti-tuberculosis Drugs." Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-318845.

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Tuberculosis is an ancient infectious disease and a leading cause of death globally. Preclinical research is important for defining drugs and regimens which should be carried forward to human studies. This thesis aims to characterize the population pharmacokinetics and exposure-response relationships of anti-tubercular drugs alone and in combinations, and to suggest experimental designs for preclinical settings. The population pharmacokinetics of rifampicin, isoniazid, ethambutol and pyrazinamide were described for the first time in two mouse models. This allowed for linking the population pha

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42

Mogatle, Seloi. "African traditional medicines-antiretroviral drug interactions: the effect of African potato (Hypoxis hemerocallidea) on the pharmacokinetics of efavirenz in humans." Thesis, Rhodes University, 2009. http://hdl.handle.net/10962/d1003251.

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African Potato (Hypoxis hemerocallidea), (AP) is an African traditional medicine (TM) that is commonly used for various nutritional/medicinal purposes and also by people infected with the human immuno deficiency virus HIV and AIDS patients as an immune booster. The use of AP has also been recommended by the former Minister of Health of South Africa for use by HIV positive people. The main phytochemical component of AP is a norlignan glucoside, hypoxoside, and other relatively minor components have also been reported. A recent in vitro study reported the effects of AP extracts, hypoxoside and r

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43

Croft, M. L. "Applications of human microdosing with accelerator mass spectrometry : assessment of ability to predict drug-drug interactions and determine the pharmacokinetics of enantiomers." Thesis, University of York, 2012. http://etheses.whiterose.ac.uk/4366/.

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In this thesis, new applications of microdosing were explored in two clinical trials. Methods were developed for the separation and quantification of 14C-labelled analytes in human plasma using two-dimensional HPLC and accelerator mass spectrometry (AMS). Caffeine, midazolam, tolbutamide and fexofenadine were quantified in plasma after administration of a 14C-labelled cassette microdose to human volunteers via a HPLC-AMS recovery constant method. Mean accuracy for all analytes was within 13% of the measured plasma concentration with precision of <20% CV, meeting recommended acceptance criteria

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44

Sadiq, Muhammad Waqas. "In Vivo Active Drug Uptake and Efflux at the Blood-Brain Barrier : With Focus on Drug Transport Interactions." Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-180824.

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The blood-brain barrier (BBB) controls the movement of substances into and out of the brain. The tight junctions between endothelial cells and energy dependent transporters in the BBB influence rate and extent of drug distribution to the brain. The aim of this thesis was to study different methodological and pharmacokinetic aspects of drug transport at the BBB by characterizing possible active uptake and drug-drug interactions. Therefore, advanced tools for data acquisition and analysis were applied. The role of BBB transport in early drug development, with particular emphasis on in vitro-in v

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Karnik, Shreyas. "Mining Biomedical Literature to Extract Pharmacokinetic Drug-Drug Interactions." Thesis, 2014. http://hdl.handle.net/1805/3912.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Polypharmacy is a general clinical practice, there is a high chance that multiple administered drugs will interfere with each other, such phenomenon is called drug-drug interaction (DDI). DDI occurs when drugs administered change each other's pharmacokinetic (PK) or pharmacodynamic (PD) response. DDIs in many ways affect the overall effectiveness of the drug or at some times pose a risk of serious side effects to the patients thus, it becomes very challenging to for the successful drug development and clinical patient care. Biomedica

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Chen, Yun-An, and 陳韻安. "Pharmacokinetic Studies ofDrug-Drug Interactions by Renal Organic Anion Transporter Iin Rabbits." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/97746703135254624600.

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碩士<br>臺北醫學大學<br>藥學研究所<br>97<br>Carrier-mediated processes, often referred to as transporters which located on the membrane, play key roles in the reabsorption and secretion of many endogenous and xenobiotic compounds by the kidney. In recent years, the specific roles of such transporters in drug disposition and drug-drug interactions become more important. The purpose of this study is to estimate the interaction of drugs with the organic anion transporter I (OATI) in the kidney. An accuracy, precision, simple and specific HPLC method was developed to detect the concentration of p-aminohipp

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Landersdorfer, Cornelia. "Modern pharmacokinetic-pharmacodynamic techniques to study physiological mechanisms of pharmacokinetic drug-drug interactions and disposition of antibiotics and to assess clinical relevance." Doctoral thesis, 2006. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-19340.

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There are numerous areas of application for which PKPD models are a valuable tool. We studied dose linearity, bone penetration and drug-drug interactions of antibiotics by PKPD modeling. Knowledge about possible saturation of elimination pathways at therapeutic concentrations is important for studying the probability of successful treatment of dosage regimens via MCS at various doses, other modes of administration, or both. We studied the dose linearity of flucloxacillin and piperacillin. For data analysis of the dose linearity studies, population PK modeling and MCS was used. Population PK ha

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Braz, Ana Sofia Pereira. "Review of drug interactions among the residents of a retirement home using different interaction databases." Master's thesis, 2016. http://hdl.handle.net/10451/35773.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2016<br>A polimedicação é um problema atual que coloca os doentes sobre um elevado risco de sofrerem interações medicamentosas. Isto verifica-se sobretudo na população idosa, que devido às comorbilidades e às mudanças fisiológicas associadas à idade, são especialmente vulneráveis a estas interações. Os mecanismos envolvidos nas interações entre fármacos podem afetar a farmacocinética ou a farmacodinâmica de um ou de ambos os fármacos em questão. O grande desafio da prática clínica é

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"Mechanistic study of the pharmacokinetic herb-drug interactions between danshen-gegen formula and warfarin." 2014. http://repository.lib.cuhk.edu.hk/en/item/cuhk-1291818.

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Zhang, Zhen.<br>Thesis Ph.D. Chinese University of Hong Kong 2014.<br>Includes bibliographical references (leaves 215-249).<br>Abstracts also in Chinese.<br>Title from PDF title page (viewed on 15, November, 2016).

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Lai, Ming-Yen, and 賴明彥. "A Study on Pharmacokinetic Interactions between St. John’s wort and Indinavir in Rat Small Intestine." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/67495966144012119710.

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碩士<br>國立臺灣大學<br>藥學研究所<br>93<br>In recent years, St. John''s wort (Hypericum perforatum, SJW) was used as an alternative therapy for the treatment of mild to moderate depression. Several active compounds from SJW have been isolated, including hypericin, pseudohypericin and hyperforin, etc. Besides, SJW may affect the activities of P-glycoprotein (Pgp) and cytochrome P450 (CYPs) in rats and human. In some clinical observations, SJW can reduce the plasma concentrations of indinavir, a HIV protease inhibitor, which is a substrate of CYP3A4 and Pgp. Therefore, a rat small intestine perfusion model

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