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Tesis sobre el tema "Phosphorylation"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 25 de julio de 2025

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1

Hirose, Masayuki. "Phosphorylation and recruitment of Syk by ITAM-based phosphorylation of tamalin." Kyoto University, 2004. http://hdl.handle.net/2433/145291.

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2

Napper, Scott. "Phosphorylation sites of HPr." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0020/NQ43518.pdf.

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3

Craig, Timothy James. "Phosphorylation of exocytotic proteins." Thesis, University of Liverpool, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406719.

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4

Ackerley, Steven. "Neurofilament transport and phosphorylation." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289881.

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5

Cleverly, Karen Elizabeth. "Investigation of neurofilament phosphorylation." Thesis, King's College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267652.

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6

Chaubey, Mark. "Phosphorylation of endocytic proteins." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.615671.

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7

Thurston, Barbara. "Protein Phosphorylation in Archaea." Diss., Virginia Tech, 1997. http://hdl.handle.net/10919/30617.

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Protein phosphorylation constitutes an important mechanism for cellular regulation in both Eucarya and Bacteria. All living organisms evolved from a common progenitor; this implies that protein phosphorylation as a means of regulation also exists in Archaea. Previously, in the sulfur-dependent archaeon Sulfolobus solfataricus a gene was cloned encoding a protein-serine/threonine phosphatase that was similar to eucaryal protein-serine/threonine phosphatases type 1, 2A, and 2B. To identify protein phosphatases in other archaeons, oligonucleotides encoding conserved regions of eucaryal

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8

Martins, Filipa de Sá. "Abeta dependent tau phosphorylation." Master's thesis, Universidade de Aveiro, 2011. http://hdl.handle.net/10773/7647.

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Mestrado em Biomedicina Molecular<br>Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the presence of two histopathological hallmarks: the extracellular amyloid plaques (APs) composed of beta-amyloid protein (Abeta) and intracellular neurofibrillary tangles (NFTs), containing hyperphosphorylated tau protein. Therefore, Abeta and tau are important molecules associated with AD and evidence suggests that Abeta may initiate the hyperphosphorylation of tau, which by disrupting neuronal network leads to the process of neurodegeneration. In the present study, using rat primar

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9

Rardin, Matthew James. "Reversible phosphorylation in mitochondria." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p3331484.

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Thesis (Ph. D.)--University of California, San Diego, 2008.<br>Title from first page of PDF file (viewed Dec. 16, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

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10

Wang, Huachun. "Protein phosphorylation regulation in Arabidopsis." Diss., Columbia, Mo. : University of Missouri-Columbia, 2006. http://hdl.handle.net/10355/5896.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2006.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on July 18, 2008) Vita. Includes bibliographical references.

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11

Carr, M. D. "NMR studies of oxidative phosphorylation." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382584.

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12

Wells, Nicholas James. "Phosphorylation of human topoisomerase II." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318833.

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13

Russell, Elinor Kate. "Engineering phosphorylation responsive peptide complexes." Thesis, University of Leeds, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.515786.

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14

Morris, Lorna Josephine. "Regulation of E2F by phosphorylation." Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398675.

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15

Selitsianos, Dimitrios. "Approaches to asymmetric chemical phosphorylation." Thesis, University of Newcastle Upon Tyne, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413042.

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16

Turner, A. M. "Protein phosphorylation in Rhodomicrobium vannielii." Thesis, University of Warwick, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383358.

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17

Thornhill, Paul. "Neurofilament phosphorylation and axonal transport." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272216.

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18

Davis, Daniel Robert. "Modulation of neuronal tau phosphorylation." Thesis, King's College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299450.

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19

Kousar, Rehana. "Regulation of eIF2B by phosphorylation." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/regulation-of-eif2b-by-phosphorylation(82439f9a-9ed1-4708-a87f-f0bcc6f4b64e).html.

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The ability to sense and respond to environmental cues is crucial for the survival of all organisms. This response is often manifested by exerting control at different levels of gene expression, i.e. transcription, translation and post translation levels. Global control of protein synthesis is frequently exercised at the initial step of translation initiation and is generally achieved by changes in the phosphorylation state of initiation factors or the regulators that interact with them. The formation of ternary complex (TC) is considered first step of translation initiation and depends on the

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20

Zhao, Y. "Pot1 phosphorylation regulates telomere function." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1380712/.

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The telomere is a conserved nucleoprotein structure at the ends of eukaryotic chromosomes. It is essential for maintenance of genomic stability: on the one hand, it suppresses DNA damage response and protects the natural chromosome ends from repair activities; on the other hand, it recruits telomerase, the specialized reverse transcriptase, to counteract the end-replication problem. The telomeric G-strand ssDNA-binding protein Pot1 plays a crucial role in both of these functions. In fission yeast S. pombe, inhibition of Pot1 induces rampant 5’ resection and loss of telomere signal in a single

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21

Gonçalves, Joana Araújo Monteiro Antão. "Multiple phosphorylation of Histatin 1." Master's thesis, Universidade de Aveiro, 2005. http://hdl.handle.net/10773/4726.

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Mestrado em Métodos Biomoleculares Avançados<br>As histatinas pertencem a uma família de peptídeos básicos ricos em histidinas que se encontram na saliva humana (Oppenheim et al., 1988). As principais histatinas, designadas histatinas 1 e 3, são codificadas pelos genes HTN1 e HTN2, localizados no cromossoma 4q13 (Sabatini et al., 1993). A histatina 3 é submetida a uma fragmentação pré-secretória, presumivelmente pela acção de uma convertase furin-like, e cria pelo menos 24 diferentes histatinas menores. Pelo contrário, a histatina 1, um peptídeo de 38 resíduos de amino ácidos, que comparte lar

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22

Quezada, Cindy Maria Richards John Gray Harry B. "Histidine phosphorylation in bacterial chemotaxis /." Diss., Pasadena, Calif. : California Institute of Technology, 2003. http://resolver.caltech.edu/CaltechETD:etd-05302003-145522.

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23

Nicoll, James B. "TR Phosphorylation & Nuclear Import." W&M ScholarWorks, 2001. https://scholarworks.wm.edu/etd/1539626303.

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24

Nadeau, Robert J. "Sprouty Regulation of Tyrosine Kinase Signal Transduction is Governed by Tyrosine Phosphorylation: A Functional Role for Sprouty2 N- and C- Terminal Tyrosines." Fogler Library, University of Maine, 2006. http://www.library.umaine.edu/theses/pdf/NadeauRJ2006.pdf.

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25

Groslambert, Marine. "Etude de l'impact fonctionnel des modifications post-traductionnelles dans l'activation de l'inflammasome NLRP3." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSEN022.

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L'inflammation est un processus déclenché suite à la détection de pathogènes et de dommages tissulaires. Elle conduit à la sécrétion de cytokines pro-inflammatoires par les cellules immunitaires innées ainsi qu'au déclenchement de la pyroptose, mort cellulaire pro-inflammatoire. NLRP3 est une protéine senseur de stress cellulaire régulant le déclenchement de ces processus via la formation d'une plateforme multiprotéique appelée inflammasome. L'activation non contrôllée de NLRP3 conduit au développement d'une maladie auto-inflammatoire appelée CAPS (Cryopyrin associated periodic syndrome). De p

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26

Koss, David John. "Phosphorylation based Models of Neurodegenerative Diseases." Thesis, University of Aberdeen, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485668.

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Aberrant protein phosphorylation is a hallmark of neurodegenerative diseases, such as Alzheimer's disease (AD) and tauopathies. Pathological phosphorylation is commonly observed as intracellular tau containing deposits correlating with neuronal death. Tau is a cytoskeletal protein, key to the stabilisation of the microtubules (MT), important ,for structural integrity and protein trafficking. Tau's ability to promote MTs is regulated by protein phosphorylation by kinases/phosphatases. In spontaneous AD, the activity/expression of kinases are enhanced w$ilst phosphatases are decreased. Alteratio

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27

Javad, Safaei Mehranpour. "Modelling human cell protein phosphorylation networks." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/52983.

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Defects in cell signalling networks are linked to over 400 human diseases. My thesis research aimed to model these networks in more detail to facilitate understanding of their architecture and operations under normal and pathological conditions. The various protein levels in diverse normal human cell and tissue types were inferred from their mRNA expressions, and their up/down-regulation was also investigated in about 300 human cancer cell lines and 50 types of human cancers. This was based on meta-analyses of gene microarray measurements deposited in the USA National Center for Biotechnology

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28

Eijsden, Rudy Gerardus Elisabeth van. "Microarray analysis of oxidative phosphorylation disorders." [Maastricht] : Maastricht : Maastricht University ; University Library, Universiteit Maastricht [host], 2008. http://arno.unimaas.nl/show.cgi?fid=10708.

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29

Cumming, D. V. E. "Nuclear protein phosphorylation in rat liver." Thesis, University of Oxford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375227.

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30

Sapountzi, Vasileia. "Study of TIP60 regulation by phosphorylation." Thesis, University of Newcastle Upon Tyne, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424155.

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31

Carter, Simon Mark. "Phosphorylation of the cardiac ryanodine receptor." Thesis, University of Bristol, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432739.

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32

Patek, Samantha Clare. "Androgen receptor phosphorylation in prostate cancer." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/38914/.

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Prostate cancer is the most common male cancer in the UK. Although incidence is increasing, prostate cancer mortality is decreasing, mainly owing to the over diagnosis of disease that would not have become clinically apparent during the patient’s lifetime. The gold-standard for prostate cancer diagnosis is transrectal ultrasound guided biopsy of the prostate. Whilst prostate biopsy can inform on diagnosis, it’s prognostic ultiltiy is poor. Currently clinicians lack pathological biomarkers to differentiate between patients with prostate cancer who have indolent disease that can be safely manage

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33

Hauser, Anett. "Chemical Approaches to Elucidate Lysine Phosphorylation." Doctoral thesis, Humboldt-Universität zu Berlin, 2021. http://dx.doi.org/10.18452/22287.

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Reversible Phosphorylierung ist die bekannteste posttranslationale Modifikation (PTM) und die O-Phosphomonoester von Serin, Threonin und Tyrosin galten lange als die einzigen relevanten Vertreter. Vor kurzem wurden erste Erkenntnisse über die biologische Relevanz von labilen Phosphorylierungen veröffentlicht, z.B. die Phosphorylierung von Histidin, Arginin und Cystein sowie die Pyrophosphorylierung von Serin und Threonin. Auch die Aufklärung von Phospho-Lysin (pLys) wurde mit der Etablierung einer chemoselektiven Synthese zur Darstellung ortsselektiv phosphorylierter Lysinpeptide und der Entwi

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34

Landais, Jean-Christophe. "La Phosphorylation du collagène de l'os." Paris 6, 1991. http://www.theses.fr/1991PA066190.

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La mise en évidence de résidus d'acide gamma-phosphoglutamique (P-GLU) liés spécifiquement ou situés dans la chapine alpha 2 du collagène de type i de tissus minéralisés a permis de penser que ces résidus pouvaient être des sites de fixation du calcium et par suite d'initiation de la minéralisation observée dans des sites spécifiques des fibres de collagène. Nous avons essaye de localiser le p-glu dans le collagène extrait de l'os et dans le collagène synthétise par des ostéoblastes en culture de cellules. Les résultats obtenus sont contradictoires. Dans certains cas, nous observons une locali

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35

Dreier, Megan Renee. "The Regulation of Sororin by Phosphorylation." University of Toledo / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1333736093.

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36

DELATTRE, DELPHINE. "Phosphorylation des proteines chez bacillus subtilis." Paris 7, 2000. http://www.theses.fr/2000PA077059.

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Les etudes concernant les phenomenes de phosphorylation des proteines sur les residus ser/thr ou tyr ont montre l'importance de ce mode de regulation chez les eucaryotes. L'objectif de cette these etait d'etudier la phosphorylation de proteines sur ces residus chez bacillus subtilis. Tout d'abord, une centaine de proteines phosphorylees ont ete detectees apres marquage in vivo et separation par electrophorese 2-d ( 3 2p). Certaines d'entre elles ont ete identifiees et les genes correspondants clones. Les proteines, fusionnees a un histag, ont ete surproduites et purifiees. Parmi elles, l'alkyl

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37

Oliveira, Joana Machado de. "Abnormal protein phosphorylation in Alzheimer's disease." Master's thesis, Universidade de Aveiro, 2011. http://hdl.handle.net/10773/7388.

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Mestrado em Biomedicina Molecular<br>AD is a neurodegenerative disorder neuropathologically characterized by the presence of senile plaques, neurofibrillary tangles and synaptic loss. The Aβ peptide, the major constituent of senile plaques, is a key player in AD pathology since increased Aβ production and aggregation was associated with neurotoxicity, activation of inflammatory response, and apoptotic cascades. These processes are associated with neuronal death, neurodegeneration and consequently gradual cognitive decline. Altered signal transduction is also thought to be one of the key

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38

Bastos, Maria de Fátima Camões Sobral de. "Aluminium neurotoxicity and neuronal phosphorylation systems." Doctoral thesis, Universidade de Aveiro, 2007. http://hdl.handle.net/10773/938.

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Doutoramento em Biologia<br>O alumínio é o terceiro elemento mais abundante na Terra. Uma vez que se encontra distribuído ubiquamente pelo meio ambiente e é utilizado em vários produtos e processos, a população humana está inevitavelmente exposta diariamente a este metal. De facto, o alumínio tem sido relacionado com diversas doenças neurodegenerativas como: a esclerose lateral amiotrófica, a demência de Parkinson (DP), a doença de Alzheimer (DA) e a encefalopatia relacionada com a diálise. A fosforilação de proteínas é um dos principais mecanismos reguladores intracelulares da maior p

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39

Panayiotou, R. "Phosphorylation mediated regulation of MRTF-A." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1462479/.

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The transcription factor SRF (Serum Response Factor) regulates expression of target genes in response to changes in actin dynamics, by virtue of association with the Myocardin Related Transcription Factor (MRTF) family of transcription cofactors. MRTF-A senses changes in actin dynamics via direct G-actin binding to its RPEL domain. While bound to actin MRTF-A continuously shuttles between the nucleus and cytoplasm, but localises to the cytoplasm due to a high export rate. Because MRTF-A is exported by Crm1 in an actin dependent manner, dissociation from actin leads to nuclear accumulation and

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40

Fagerholm, Susanna. "Bidirectional signalling and phosphorylation of CD11 /." Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/mat/bioti/vk/fagerholm/.

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41

Al, Jabry Tariq Saud Hamad. "Characterising the phosphorylation of YB-1." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/15336.

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The Y-Box-binding protein-1 (YB-1) is a ubiquitous and multifunctional protein involved in several cellular processes such as transcription, mRNA splicing, and translation. YB-1 has been shown to be of significance to the area of cancer research, where it has been observed to be expressed at elevated levels in~40% of invasive breast carcinomas and a number of other malignancies. Within the nucleus, it has been reported to induce the transcription of a variety of genes, including oncogenes that upregulate cell proliferation, migration, and invasion. The phosphorylation of YB-1 at serine 102 has

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42

Willder, Jennifer Mary. "Androgen receptor phosphorylation in prostate diseases." Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/5797/.

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Prostatic diseases are common; benign prostate hyperplasia (BPH) is almost ubiquitous in elderly men and 899,000 men were diagnosed with prostate cancer worldwide in 2008. The incidence of both is increasing and expected to continue to rise. Therefore, prostatic diseases represent a considerable economic burden, but there are currently no reliable markers available to accurately differentiate indolent from aggressive disease nor to predict who will benefit from treatment for either BPH or prostate cancer. This results in over and under-treatment of both diseases with consequent patient related

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43

Schubert, Alexander Fabian. "Mechanism of PINK1-mediated ubiquitin phosphorylation." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/277271.

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Ubiquitin phosphorylation by PINK1 (PTEN-induced Putative Kinase 1) is crucial for mitochondrial quality control and loss or mutation of PINK1 can lead to autosomal recessive juvenile parkinsonism (AR-JP). PINK1 is an unusual kinase, as it is characterised by three unique insertions in its kinase N lobe and a C-terminal region after the kinase domain. Despite great effort, a structure of PINK1 could not be determined and the molecular mechanism of ubiquitin phosphorylation and the effect of the PINK1 AR-JP patient mutations remained elusive. The versatile modifier ubiquitin (Ub) is also an unu

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44

Goveas, Liesel Mary. "LRRK2 phosphorylation - phosphophenotypes, biomarkers and targeting." Electronic Thesis or Diss., Université de Lille (2022-....), 2023. http://www.theses.fr/2023ULILS015.

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Les mutations de la Leucine-Rich Repeat Kinase 2 (LRRK2) sont liées à la maladie de Parkinson (MP). Le gène LRRK2 code pour une protéine multiphosphorylée comportant plusieurs domaines fonctionnels impliqués dans l'interaction protéine-protéine, la GTPase et l'activité kinase. Le ciblage de l'activité kinase de LRRK2 fait l'objet de nombreuses recherches, et plusieurs composés sont en cours d'évaluation en test clinique. D'autres fonctions de LRRK2 sont également étudiées pour leurs liens avec les pathomécanismes de la MP. Des études suggèrent que la phosphorégulation de LRRK2 est essentielle

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45

Hébert, Chatelain Etienne. "Impact des phosphorylations sur tyrosine sur le métabolisme mitochondrial : régulation et impacts fonctionnels des phosphorylations induites par la Src kinase." Thesis, Bordeaux 2, 2011. http://www.theses.fr/2011BOR21830/document.

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La mitochondrie est une organelle très importante vu son implication dans plusieurs processus cellulaires. Elle produit notamment la majeure partie de l'énergie qui est consommée par la cellule, grâce aux processus d'oxydation phosphorylante (OXPHOS). La phosphorylation des enzymes impliquées dans les OXPHOS apparait comme une voie de régulation importante de la production énergétique. L'objectif de ce thèse était donc de comprendre comment les phosphorylations, et plus particulièrement, les phosphorylations sur tyrosine induites par la Src kinase influencent les OXPHOS. Il a donc été démontré

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46

Faure, Camille. "Régulation de la localisation et de l'activation de la tyrosine kinase Pyk2 (Proline-rich tyrosine kinase 2)." Paris 6, 2010. http://www.theses.fr/2009PA066736.

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Proline-rich tyrosine kinase 2 (Pyk2) est une tyrosine kinase non récépteur de 110-kDa deappartenant à la famille de focal adhesion kinase (FAK). Elle a été initialement caractérisée comme une enzyme cytoplasmique. Elle est, régulée par autophosphorylation (sur la tyrosine 402) en réponse à l’des augmentations de la concentration de Ca2+calcium libre cytosolique. L’autophosphorylation de Pyk2 est cruciale pour son activation puisqu’elle permet le recrutement des membres de la famille de Src, conduisant à l’ac’tivation de nombreuses voies de signalisation. Pyk2 existe sous deux isoformes produi

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47

Blanquart, Christophe. "Etude des modifications post-traductionnelles du Peroxisome Proliferator Activated Receptor Alpha (PPAR Alpha) et de leurs conséquences sur les fonctions biologiques de ce récepteur nucléaire." Lille 2, 2003. http://www.theses.fr/2003LIL2P015.

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PPARα appartient à la superfamille des récepteurs nucléaires (RN). C'est un facteur de transcription activé par des ligands. PPARα est impliqué dans la régulation du métabolisme des lipides et des lipoprotéines ainsi que dans le contrôle de la réponse inflammatoire. Ces différentes fonctions lui confèrent un rôle protecteur contre l’athérosclérose. Le but de nos travaux a été de mettre en évidence diverses modifications post-traductionnelles de PPARα ainsi que de définir leurs conséquences sur les fonctions de ce RN. Ainsi, nous avons montré que la protéine PPARα est ubiquitinée, ce qui condui

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48

Abukhalaf, Imad Kazem. "Application of Synthetic Peptides as Substrates for Reversible Phosphorylation." Thesis, University of North Texas, 1992. https://digital.library.unt.edu/ark:/67531/metadc277577/.

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Two highly homologous synthetic peptides MLC(3-13) (K-R-A-K-A-K-T-TK-K-R-G) and MLC(5-13) (A-K-A-K-T-T-K-K-R-G) corresponding to the amino terminal amino acid sequence of smooth muscle myosin light chain were utilized as substrates for protein kinase C purified from murine lymphosarcoma tumors to determine the role of the primary amino acid sequence of protein kinase C substrates in defining the lipid (phosphatidyl serine and diacylglycerol) requirements for the activation of the enzyme. Removal of the basic residues lysine and arginine from the amino terminus of MLC(3-13) did not have a signi

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49

Halbedel, Sven. "Regulation of HPr phosphorylation in Mycoplasma pneumoniae." Doctoral thesis, [S.l.] : [s.n.], 2006. http://webdoc.sub.gwdg.de/diss/2006/halbedel.

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50

Sundstrom, Jeffrey Antonetti David A. "Identification and functional analysis of occludin phosphorylation." [University Park, Pa.] : Pennsylvania State University, 2008. http://etda.libraries.psu.edu/theses/approved/WorldWideIndex/ETD-2566/index.html.

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