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Tesis sobre el tema "PPT1"

Autor: Grafiati
Publicado: 10 de marzo de 2023

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1

Vilímek, Hynek. "Převod PPTX do HTML." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2016. http://www.nusl.cz/ntk/nusl-255407.

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PowerPoint is an excellent tool for creating presentations and people are accustomed to using it. Its only handicap is that it is not installed everywhere and it exists in numerous versions. But there is an application that is installed almost everywhere and that application is the web browser. This work aims to create the PowerPoint presentation viewer for the web browser. With the internet as the environment, it may have a wide range of applications from the content sharing point of view. The solution is a web application that allows to upload the PowerPoint file and then the application dis
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2

Anzi, C. "Pattern di espressione del gene Ppi1 e analisi di mutanti ppi1 e ppi 2 in Arabidopsis thaliana." Doctoral thesis, Università degli Studi di Milano, 2008. http://hdl.handle.net/2434/61194.

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The proton pump interactor (Ppi) gene family of Arabidopsis thaliana: expression pattern of Ppi1 and characterisation of knockout mutants for Ppi1 and 2. Plant plasma membrane H+-ATPases (PM H+-ATPase) are essential for establishing a proton electrochemical gradient across the cell plasma membrane. Their regulation is poorly understood, except for the role of 14-3-3 proteins, which relieve autoinhibition from the C-terminal domain. A novel protein interacting with this domain was recently identified in Arabidopsis and named PPI1 (Proton Pump Interactor 1). PPI1 stimulates PM H+-ATPase activity
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Soler, David C. "The PP1 gamma isoforms restore spermatogenesis but not fertility in PP1 gamma null mice." [Kent, Ohio] : Kent State University, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=kent1259087463.

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Thesis (Ph.D.)--Kent State University, 2009.<br>Title from PDF t.p. (viewed May 17, 2010). Advisor: Srinivasan Vijayaraghavan. Keywords: sperm; spermatogenesis; PP1gamma2; PP1gamma1; mice; transgene. Includes bibliographical references (p. 102-123).
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4

Gregório, Luís Korrodi Mineiro Marques. "Characterization of PPP1 interacting proteins in male reproduction." Doctoral thesis, Universidade de Aveiro, 2012. http://hdl.handle.net/10773/7826.

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Doutoramento em Bioquímica<br>A fosforilação reversível de proteínas é um importante mecanismo de controlo em eucariotas. A fosfoproteína fosfatase 1 (PPP1) é uma fosfatase de serina/treonina envolvida em vários processos celulares. Existem três isoformas da subunidade catalítica (α/CA, δ/β/CB e γ/CC) com pequenas diferenças nos terminais amino e carboxílico. O gene PPP1CC sofre ainda splicing alternativo para produzir duas isoformas, a PPP1CC1 ubíqua e a PPP1CC2 enriquecida em testículo e específica de esperma. A localização e especificidade de substratos da PPP1 está dependente da formação d
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Sousa, Luís Miguel dos Santos. "TCTEX1D4 and PPP1: TGFß pathway and prostate cancer." Master's thesis, Universidade de Aveiro, 2013. http://hdl.handle.net/10773/11571.

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Mestrado em Biomedicina Molecular<br>T-complex testis expressed protein 1 domain containing 4 (TCTEX1D4) é uma cadeia leve de dineina que foi identificada como sendo uma proteína que interage com a PPP1. As funções específicas da TCTEX1D4 ainda permanecem desconhecidas mas a identificação dos seus interactores pode elucidar sobre as suas funções em sistemas biológicos. No interactoma da TCTEX1D4 merece particular destaque a presença de diversas proteínas associadas à via de sinalização do TGFβ e cuja desregulação se encontra associada ao cancro da próstata. Desta forma, foi objectivo de
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6

Chaudry, Tanya N. "Characterisation of PP71 homologues encoded by mammalian cytomegaloviruses." Thesis, Connect to e-thesis, 2008. http://theses.gla.ac.uk/377/.

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Thesis (Ph.D.) - University of Glasgow, 2008.<br>Ph.D. thesis submitted to the Division of Virology, Institute of Biomedical and Life Sciences, University of Glasgow, 2008. Includes bibliographical references. Print version also available.
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7

Zhao, Yiqiang. "Functional Analysis of Human Cytomegalovirus (HCMV) US3 and pp71." Ohio University / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou995293805.

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8

Prechova, M. "Functional analysis of PP1 regulator Phactr1." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10046874/.

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The Phosphatase and actin regulator (Phactr) protein family has been identified as a group of four proteins (Phactr1,2,3,4), interacting with Protein Phosphatase 1 (PP1) and G-actin. G-actin binding to Phactr1 RPEL motifs has been shown to sterically inhibit Phactr1 interaction with PP1 and its nuclear import. Members of the Phactr family are highly expressed in the nervous system and have been implicated in the regulation of the actin cytoskeleton, cell migration and angiogenesis. The molecular mechanism of their signalling is however not well understood. Here I show that Phactr1 functions as
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9

Broad, William. "Elucidating the function of the suppressor of ppi1 locus 2." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:81cb5fb1-e735-453c-9c4b-332a5aa16b27.

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10

Fox, Helen. "PP1 localisation and function during fungal morphogenesis." Thesis, University of East Anglia, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327586.

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11

Molero, Merinero Cristina. "Molecular characterization of the Ppz1 phosphatase and its regulatory subunit Hal3." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/454816.

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La proteína Ser / Thr fosfatasa Ppz1 de S. cerevisiae es un componente importante en el mantenimiento de la homeostasis de cationes monovalentes (K+ y Na+) y, como tal, incide en múltiples procesos celulares, tales como la progresión del ciclo celular y el mantenimiento de la integridad celular. La homeostasis de cationes es un factor clave para la supervivencia de cualquier célula, particularmente para los microorganismos que, como las levaduras, deben hacer frente a los cambios ambientales. Aunque Ppz1 es un enzima relacionado con la ubicua fosfatasa tipo 1 (PP1c), las enzimas tipo Ppz sólo
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12

Tryggvason, Thorir. "Analysis of the PPTP and IPSec protocols in Virtual Private Networks." Thesis, University of Skövde, Department of Computer Science, 2000. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-415.

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<p>Today increasing numbers of individuals are working away from the ordinary workplace while still requiring access to the server located at the workplace. New technology is meeting this demand allowing for safe and secure transmission of the data over the Internet. The aim of this project is to analyse two protocols that are used within the Virtual Private Network (VPN) structure today, with the focus on installation, transmission speed on both Local Area Networks (LAN) and via telephone line and security aspects of the protocols.</p><p>The results show that it is quite complicated to setup
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13

Candon, Heather L. "Polyphosphate kinase 1 (PPK1) is a pathogenesis determinant in Campylobacter jejuni." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/31547.

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Campylobacter jejuni (C. jejuni) is the leading cause of bacterial gastroenteritis in the developed world. Despite the prevalence of C. jejuni as a human pathogen, relatively little is known about it's precise pathogenesis mechanisms, particularly in comparison to other well-studied enteric pathogens like E. coli and Salmonella spp. Altered expression of phosphate genes in a C.jejuni stringent response mutant, together with known correlations between the stringent response, polyphosphate (poly P), and virulence in other pathogens, led us to investigate the role of poly P in C. jejuni physiolog
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14

Nicholson, Iain Peter. "Characterisation of two homologues of the human cytomegalovirus transactivating protein pp71." Thesis, University of Glasgow, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398661.

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15

Fernandes, Emanuel Ferreira. "The role of Synphilin-1A/PPP1 complex in Lewy bodies formation." Master's thesis, Universidade de Aveiro, 2013. http://hdl.handle.net/10773/12488.

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Mestrado em Biomedicina Molecular<br>One of the major Parkinson’s disease hallmarks is the development of cytoplasmic inclusions, termed Lewy bodies, mainly within surviving neurons in the brainstem of affected patients. Many proteins have been identified in the Lewy bodies, but their formation mechanism remains unclear. Among the proteins already identified in the Lewy bodies are synphilin-1, a α-synucleininteracting protein, and synphilin-1A, a synphilin-1 splice variant. Synphilin-1 and synphilin-1A have been considered key elements in Parkinson’s disease as their overexpression in human em
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16

Felgueiras, Juliana Carina Cardoso. "The role of TCTEX1D4/PPP1 complex in cell proliferation and migration." Master's thesis, Universidade de Aveiro, 2013. http://hdl.handle.net/10773/12507.

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Mestrado em Biomedicina Molecular<br>Prostate cancer is one of the most prevalent and incident cancer in men, being a disquieting cause of men’s death worldwide. The widespread implementation of prostate-specific antigen (PSA) screening and the improvements on prostate cancer therapy have been leading to a markedly decrease in mortality. However, PSA use is controversial since it has been leading to the diagnosis and treatment of several prostate cancer cases that would not otherwise cause symptoms or threaten man’s life. Hence, the establishment of a panel of biomarkers and the discovery of
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17

Voll, Ane-Idun. "Samhandling mellom skole og PPT : En kvalitativ og kvantitativ studie fra et småskalaprosjekt i regi av Faglig Løft for PPT." Thesis, Norges teknisk-naturvitenskapelige universitet, Pedagogisk institutt, 2012. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-17568.

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Faglig Løft for PPT er et 4-årig modellforsøk som avsluttes i 2012. Etablering av prosjektet begrunnes i et behov for kompetanseheving hos PPT. Som en del av det større prosjektet Faglig løft for PPT er det etablert småskalaprosjekt i to kommuner, Samhandlingsprosjektet. Hensikten med å opprette et slikt småskalaprosjekt er å prøve ut ulike samhandlingsstrukturer, bidra til kompetansebygging og prøve ut ulike roller. I den ene kommunen, som er fokus for denne studien, er det opprettet arbeidsgrupper på hver av de seks grunnskolene i kommunen. Bakgrunnen for at kommunen deltar i Samhandlingspro
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Fardilha, Margarida Sâncio da Cruz. "Characterization of the PP1 interactome from human testis." Doctoral thesis, Universidade de Aveiro, 2003. http://hdl.handle.net/10773/4490.

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Doutoramento em Biologia<br>Protein phosphorylation is a major regulatory mechanism notably of signal transduction cascades in eukaryotic cells. Protein phosphorylation is catalysed by protein kinases and can be reversed by the action of protein phosphatases. Although phosphatases were discovered more than sixty years ago, their importance as central players in multiple cellular mechanisms was only recently recognized. PP1, a Serine/Threonine specific phosphatase, is involved in important cellular mechanisms such as the cell cycle, muscle contraction and apoptosis, among others. Its ro
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19

Wright, Thomas Matthew. "Properties of nonwoven assemblies containing mechanically processed and photo-aged PPTA fibres." Thesis, University of Leeds, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613623.

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Degradation of poly-para phenylene terephthalamide (PPTA) fibres during the manufacture of carded and hydroentangled fabric is investigated. During PPTA fibre processing operations such as fibre opening and carding, the material is subjected to applied mechanical forces resulting from interactions with machine surfaces and inter-fibre friction. Additionally, post-industrial and post-consumer sources of PPTA fibre are exposed to UV irradiation, which also has potential to influence fibre properties. The degree to which such agencies of degradation are encountered during fabric manufacture can i
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20

Juhem, Aurélie. "Identification d’un inhibiteur sélectif PP1 aux propriétés anti-tumorales." Université Joseph Fourier (Grenoble ; 1971-2015), 2008. http://www.theses.fr/2008GRE10170.

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La chimiothérapie reste une des thérapies les plus utilisées pour lutter contre le cancer. Bien qu'il existe de nombreuses molécules anti-cancéreuses, il demeure un besoin constant de nouvelles drogues thérapeutiques plus efficaces et moins toxiques. Parmi l'ensemble des médicaments disponibles pour traiter les patients, « les poisons microtubulaires », qui agissent sur la tubuline et/ou les microtubules (MTs), sont largement utilisés puisqu'ils ciblent préférentiellement les cellules qui se divisent, en provoquant un arrêt en mitose et la mort cellulaire. Cependant, l'usage de ces drogues ant
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21

Ning, Shunbin, and Ling Wang. "Identification of PP1 as the First Phosphatase for IRF7." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/6527.

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22

Esteves, Sara Luísa de Castro. "PP1 interactomes as a means of characterizing protein functions." Doctoral thesis, Universidade de Aveiro, 2012. http://hdl.handle.net/10773/10998.

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Doutoramento em Bioquímica<br>A maioria das funções celulares, incluindo expressão de genes, crescimento e proliferação celulares, metabolismo, morfologia, motilidade, comunicação intercelular e apoptose, é regulada por interações proteína-proteína (IPP). A célula responde a uma variedade de estímulos, como tal a expressão de proteínas é um processo dinâmico e os complexos formados são constituídos transitoriamente mudando de acordo com o seu ciclo funcional, adicionalmente, muitas proteínas são expressas de uma forma dependente do tipo de célula. Em qualquer instante a célula pode cont
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23

Alves, Helder Luís da Costa. "The impact of Aβ on the Neurabin/PP1 complex". Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/15017.

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Mestrado em Biomedicina Molecular<br>Our brain is a complex structure constituted by neurons capable of communicating through synapses, which generally occur between the axon terminal and the dendritic spine of two different neurons. These dendritic spines are dynamic, which allow for the rapid adaptation to the different stimuli they receive. PP1 is a phosphatase protein which catalyzes the majority of dephosphorylation reactions that occur in our body. It is involved in several different functions, from glycogen metabolism to synaptic regulation. Neurabins are two structurally and functional
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Holley, Aaron K. "Investigations of supramolecular and catalytic properties of PP1 dendrimers." Huntington, WV : [Marshall University Libraries], 2003. http://www.marshall.edu/etd/descript.asp?ref=334.

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Brusnický, Pavel. "Útoky na bezdrátovou síť." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2010. http://www.nusl.cz/ntk/nusl-218580.

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Objective of this thesis is to point out to almost everywhere present flaw in realization of second level network security access to WiFi networks with using traffic tunneling over DNS protocol. Realization has been accomplished by existing utilities OzymanDNS, DNS2TCP, NSTX, Iodine, Heyoka. Measurements were done on realistic traffic on the network. The effort was to show outline of these implementations. Transfer speeds in some implementations can be marked as applicable thanks to high speeds, which are on the same level as broadband internet. Functionality was tested on WiFi network, where
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26

Calafi, Pascual Carlos Alberto. "1 La proteína fosfatasa Ppz1 de levadura: estudios estructurales y funcionales en sobreexpresión." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2020. http://hdl.handle.net/10803/670425.

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Els enzims Ppz són proteïnes fosfatases que es troben només en fongs i es caracteritzen per un domini catalític C-terminal molt conservat, semblant al de les fosfatases PP1c, i una regió N-terminal poc conservada. En Saccharomyces cerevisiae, les fosfatases Ppz estan codificades en els gens paràlegs PPZ1 i PPZ2. Ppz1 és la proteïna més tòxica en sobreexpressió en llevat, alterant la proliferació cel·lular de manera dependent de la seva activitat fosfatasa, tot i que els mecanismes darrer d’aquesta toxicitat encara no han estat establerts. En aquest estudi intentem conèixer aquests mecanismes.
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27

Khuong, Thi thu huong. "Investigation of the regulation of photosynthesis at the molecular level for improvement of plant growth and productivity under limiting light conditions." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM4001.

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La lumière est indispensable à la survie des plantes via le processus photosynthétique, pourtant les plantes doivent s'adapter à différentes conditions environnementales où la quantité et la qualité de la lumière peuvent être non optimales pour la photosynthèse. Cela peut provoquer des dégâts photo-induits par formation d'espèces réactives de l'oxygène (ROS), qui sont dangereux pour la plante. Pour limiter la formation des ROS, les plantes mettent en place une régulation importante qui est la dissipation thermique de l'énergie absorbée en excès, appelé Non photochemical quenching (NPQ). Il est
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Spencer, Eleanor Mary. "Transcriptional regulation of preprotachykinin-A (PPT-A) in the hippocampus." Thesis, University of Liverpool, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433413.

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Schneider, Georg [Verfasser]. "300 ppt Measurement of the Proton g-Factor / Georg Schneider." Mainz : Universitätsbibliothek Mainz, 2018. http://d-nb.info/1162145307/34.

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Figueiredo, João Daniel Amaral. "The effect of anticancer drugs prodiginines in PP1 in melanoma." Master's thesis, Universidade de Aveiro, 2011. http://hdl.handle.net/10773/6861.

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Mestrado em Biomedicina Molecular<br>Um dos principais mecanismos reguladores da função celular é a fosforilação de proteínas. É de focar que a fosforilação anormal de proteínas-chave pode estar associada a várias patologias, incluindo o cancro. Embora já existam muitos estudos sobre cinases no cancro, o conhecimento sobre as fosfatases que antagonizam a acção das cinases é muito menos. A PP1, uma das principais proteínas fosfatase de serina/treonina expressa em todas as células eucarióticas, está envolvida em vários processos celulares incluindo apoptosis e ciclo celular. Na realidade,
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Silva, Joana Vieira da. "Electron microscopy study of PP1 and SARP2 in human testis." Master's thesis, Universidade de Aveiro, 2011. http://hdl.handle.net/10773/7698.

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Mestrado em Biomedicina Molecular<br>A proteína fosfatase-1 (PP1) é uma fosfatase específica para a desfosforilação de resíduos de serina e treonina, cujas funções celulares dependem da formação de complexos com proteínas que interagem com a PP1 (PIPs). Dada a importância da PP1γ2, isoforma específica de testículo/espermatozóides, na espermatogénese e na função dos espermatozóides, é fundamental identificar as funções das PIPs específicas destes tecidos, tais como a SARP2 (Several Ankyrin Repeat Protein 2). A PP1 alcança a sua especificidade, não só pela diversidade de proteínas com as quais i
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Ferreira, Mónica Alexandra dos Santos. "I-2L, a novel putative PP1 inhibitor in human sperm." Master's thesis, Universidade de Aveiro, 2010. http://hdl.handle.net/10773/8796.

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Mestrado em Biologia Molecular e Celular<br>A proteína fosfatase-1 (PP1) é uma proteína fosfatase ubíqua e específica para a desfosforilação de resíduos de serina e treonina, que participa na regulação de diversos processos celulares. Em mamíferos, a actividade da PP1 está relacionada com a motilidade dos espermatozóides durante o percurso no tracto epididimal. Esta holoenzima é composta por uma subunidade catalítica, denominada PP1c, e por proteínas que interagem com a PP1 (PIPs) e a dirigem para a proximidade de substratos, determinando a sua actividade. A PP1 é codificada por três genes dis
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Chakrabarti, Rumela. "Role for PP1 [gamma] 2 in spermatogenesis and sperm morphogenesis." [Kent, Ohio] : Kent State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=kent1176430377.

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Thesis (Ph.D.)--Kent State University, 2007.<br>Title from PDF t.p. (viewed Mar. 12, 2009). Advisor: Srinivasan Vijayaraghavan. Keywords: sperm, testes, spermatogenesis, protein phosphatase, knock out, spermatid. Includes bibliographical references (p. 115-129).
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Muñoz, Muñoz Ivan. "Caracterització molecular de subunitats reguladores de la fosfatasa Ppz1 en el llevat saccharomyces cerevisiae." Doctoral thesis, Universitat Autònoma de Barcelona, 2004. http://hdl.handle.net/10803/3523.

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La fosfo-defosforilación de aminoácidos es uno de los procesos de regulación reversible más extendidos en los seres vivos. Este tipo de reacciones es llevado a cabo por la acción opuesta de las proteínas quinasas y las proteínas fosfatasas. A pesar de ello, el genoma de la levadura codifica un número mayor de Ser/Thr quinasas. Por ello, algunas fosfatasas han desarrollado un mecanismo de regulación distinto, que se basa en la unión de la subunidad catalítica a una o más subunidades reguladoras. Éstas determinan la localización subcelular, la especificidad por el sustrato y, en definitiva, la f
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Bentham, Matthew John. "Generation and characterisation of a human cytomegalovirus mutant lacking the virion trans-activator pp71." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621338.

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Manlan, Olivier. "Initiative PPTE et allègement de la dette de la Côte d'Ivoire : une évaluation économétrique." Paris 10, 2003. http://www.theses.fr/2003PA100172.

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Le premier objectif de cette thèse est de montrer à l'aide d'un modèle économétrique que le niveau d'allégement de la dette déterminé pour la Côte d'Ivoire dans le cadre de l'Initiative PPTE, n'est pas cohérent avec ses besoins de désendettement. Le second objectif de cette thèse est de contribuer aux fondements théoriques de l'implication à part entière de la société civile dans l'élaboration des programmes de lutte contre la pauvreté, et de manière plus générale, dans la mise en oeuvre des programmes de développement durables. Dans ce contexte, les outils de l'analyse économique que sont la
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Freitas, Maria João Martinho de. "Addressing sperm motility regulation through characterization and modulation of the GSK/PPP1R2/PPP1 signaling pathway." Doctoral thesis, Universidade de Aveiro, 2018. http://hdl.handle.net/10773/22772.

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Doutoramento em Biologia<br>Sperm motility acquisition and maintenance is a fundamental process for oocyte fertilization and consequently conception. The signaling events underling sperm motility acquisition have been studied for decades. However, many questions are still unanswered. Also, the limited options currently available for male contraception (condom, vasectomy and withdrawal) reflect the necessity of a new group of male contraceptives based on sperm motility modulation. GSK3/PPP1R2/PPP1 signaling pathway is involved in sperm motility acquisition during epididymis transit. The main go
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Laia, Marcelo Luiz de. "Clonagem e caracterização de análogos de genes de resistência e desenvolvimento de um marcador SCAR Iigado ao gene Ppr1 em Eucalyptus grandis." Universidade Federal de Viçosa, 2001. http://www.locus.ufv.br/handle/123456789/10102.

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Submitted by Marco Antônio de Ramos Chagas (mchagas@ufv.br) on 2017-04-19T17:18:55Z No. of bitstreams: 1 texto completo.pdf: 6847894 bytes, checksum: fd13826f239b9a952bf3541d2710297c (MD5)<br>Made available in DSpace on 2017-04-19T17:18:55Z (GMT). No. of bitstreams: 1 texto completo.pdf: 6847894 bytes, checksum: fd13826f239b9a952bf3541d2710297c (MD5) Previous issue date: 2001-10-18<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>A maioria dos genes de resistência (genes R) cIonados codifica proteínas que tém dominios conservados. Estas proteinas sao classificadas em cla
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Haddley, Kate. "Transcriptional regulation of the preprotachykinin-A (PPT-A) gene in neuronal cells." Thesis, University of Liverpool, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408571.

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40

Ruiz, Garzón Amparo. "Nuevos elementos reguladores y funciones celulares de la proteína fosfatasa Ppz1 en la levadura Saccharomyces cerevisiae." Doctoral thesis, Universitat Autònoma de Barcelona, 2006. http://hdl.handle.net/10803/3552.

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Las proteínas Ppz1 y Ppz2 de Saccharomyces cerevisiae son Ser/Thr fosfatasas involucradas en diferentes procesos celulares, tales como el mantenimiento de la integridad celular, la tolerancia salina y la regulación del ciclo celular en la transición G1/S. La mayor parte de los fenotipos asociados con la ausencia o la sobreexpresión de las fosfatasas Ppz son la consecuencia de la inhibición que ejercen estas fosfatasas sobre los transportadores de potasio de alta afinidad Trk1/2. En las primeras fases de este trabajo, sólo se había identificado una subunidad reguladora para estas fosfatasas, la
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41

Jesson, Jocelyn Gavin. "The PPTA and the State: from militant professionals to bargaining agent : a study of rational opportunism." Thesis, University of Auckland, 1995. http://hdl.handle.net/2292/2016.

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This thesis using oral historiographic techniques examines the changing role and function of a teachers' union during changes in the nature of a national State which can also be related to changing forms of capitalism. The teachers' union is New Zealand Post-Primary Teachers Association (the secondary school teachers' union) and the period of particular focus is between 1983 and the beginning of 1993. This is the period of a crisis in the New Zealand State during which the character of the national State was moved from what has been described as a 'wage earners' Welfare State towards a more re
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42

Idlemouden, Khadija. "Annulations de la dette extérieure et croissance : Une application au cas des "pays pauvres très endettés" (PPTE)." Phd thesis, Université Paris Dauphine - Paris IX, 2009. http://tel.archives-ouvertes.fr/tel-00419972.

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L'objectif de cette thèse est d'évaluer l'effet des réductions de la dette extérieure consenties dans le cadre de l'initiative PPTE sur la croissance. Après un rappel, dans le premier chapitre, des spécificités de la dette des PPTE, nous présentons, dans le deuxième chapitre, les caractéristiques de l'Initiative PPTE. Elle vise à rétablir la soutenabilité de la dette et à encourager la lutte contre la pauvreté. L'objectif de croissance n'y est pas explicite. Le troisième chapitre établit un lien entre la soutenabilité et la croissance à travers le modèle de fardeau virtuel. Celui-ci met en exe
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43

Faille, Alexandre. "É́tude structurale et fonctionnelle de la polykétide synthase PpsC et de son activateur PptT chez Mycobacterium tuberculosis." Toulouse 3, 2013. http://thesesups.ups-tlse.fr/2805/.

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PpsC est une polykétide synthase mono-modulaire de type I essentielle à la synthèse de facteurs de virulence chez Mycobacterium tuberculosis appelés dimycocérosates de phthiocérol. Afin d'aider à la découverte de nouveaux anti-tuberculeux et de mieux comprendre le mécanisme employé par les polykétide synthases, nous avons entrepris l'étude structurale et fonctionnelle de PpsC par cristallographie des rayons X. Les polykétide synthases de type I sont composées de plusieurs domaines, chacun possédant une activité catalytique différente. Nous avons utilisé la méthode du domain trapping pour ident
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44

Ferreira, Mónica Alexandra dos Santos. "Epigenetic control of the male progenitor germline by the protein phosphatase PP1-NIP." Doctoral thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22814.

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Doutoramento em Biologia<br>NIPP1, for nuclear inhibitor of protein phosphatase 1 (PP1), is a multifunctional scaffold protein that regulates cell signaling, pre-mRNA splicing and transcription by targeting PP1 to specific nuclear substrates. The global deletion of NIPP1 in mice is embryonic lethal at the onset of gastrulation, precluding its functional analysis in adult tissues. This prompted us to generate a tamoxifen-inducible NIPP1 knockout (iKO) mouse model. Unexpectedly, the deletion of NIPP1 was not efficient in the examined organs except for testis. The loss of NIPP1 caused an a
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45

Lenne, Astrid. "Caractérisation moléculaire et fonctionnelle de deux nouveaux partenaires potentiels de la protéine phosphatase de type 1 (PP1) chez plasmodium falciparum." Thesis, Lille 2, 2016. http://www.theses.fr/2016LIL2S016/document.

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Plasmodium falciparum (Pf) est un parasite intracellulaire capable d’infecter l’Homme. Dans les 48h après l’invasion des érythrocytes, il passe par le stade d’une cellule géante multinucléée qui se divise en 16 à 32 parasites. Cette multiplication rapide nécessite des mécanismes spécifiques de régulation très subtilement orchestrés. Parmi les modifications post-traductionnelles décrites chez les cellules eucaryotes, la phosphorylation réversible des protéines par les kinases/phosphatases est une des voies majeures dans la transduction des signaux cellulaires. Chez Plasmodium, des études de gén
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46

Hollin, Thomas. "Analyse de l’interactome de la Ser/Thr protéine phosphatase de type 1 (PP1) chez plasmodium falciparum : caractérisation moléculaire et fonctionnelle de Gametocyte EXported Protein 15." Thesis, Lille 2, 2017. http://www.theses.fr/2017LIL2S020/document.

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L’un des obstacles majeurs au développement de nouveaux antipaludiques est notre connaissance limitée de la biologie parasitaire et la rareté des cibles thérapeutiques potentielles identifiées. Les interactions protéines-protéines sont impliquées et essentielles dans divers processus biologiques incluant les modifications post-traductionnelles. Les interactions substrats-kinases ou phosphatases sont considérées comme une liaison transitoire et jouent un rôle central et essentiel dans le cycle cellulaire de Plasmodium. La Ser/Thr Protéine Phosphatase de Type 1 (PP1), l’une des phosphatases maje
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47

Serpe, Rossana. "Identification of clock neurons and downstream circuits that are involved in sleep control in Drosophila melanogaster." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS257.

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Le moment, la qualité et la quantité de sommeil dépendent de l'interaction fine entre l'horloge circadienne et la machinerie homéostatique (Borbely A. et al., 1982, Daan S. et al., 1984, Borbely et Achermann, 1999). Au cours des dernières années, l'utilisation de divers organismes modèles a fourni de nouvelles perspectives sur les mécanismes neuronaux et moléculaires de la régulation du sommeil (Miyazaki S. et al., 2017). Cependant, les bases moléculaires de l'homéostasie du sommeil et les circuits neuronaux sous-jacents à son interaction avec le réseau circadien n'ont pas été établis en détai
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48

Velázquez, Sánchez Diego. "Exploring the regulatory mechanisms of the S. cerevisiae Ppz1 protein phosphatase and the molecular basis for its toxicity." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/667958.

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Uno de los más notables componentes en la homeostasis de cationes en levaduras es la proteína fosfatasa Ppz1. El papel de Ppz1 es doble: inhibe la entrada de potasio mediante el control de la actividad de los transportadores Trk1 y Trk2 y atenúa la expresión del gen de la Na+-ATPasa ENA1. Ppz1, está controlada negativamente por dos subunidades reguladoras estructuralmente relacionadas, Hal3 y Vhs3, siendo la primera la más relevante funcionalmente. A parte de esto se ha demostrado que niveles altos de Ppz1 son extremadamente perjudiciales para la célula. El primer objetivo de este trabajo ha
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49

Johns, Anna. "Towards the development of novel Aspergillus fumigatus targeted antifungals with an in-depth analysis of Sfp-PPTase, PptA." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/towards-the-development-of-novel-aspergillus-fumigatus-targeted-antifungals-with-an-indepth-analysis-of-sfppptase-ppta(5f2e1052-01b3-4fb2-84b9-5871538351db).html.

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Humans are continuously confronted by the threat of fungal infection. Estimates put the number of individuals infected by superficial fungal disease at about 1.7 billion. Additionally there are a significant proportion of invasive infections which are difficult to treat and lead to an estimated 1.5 million deaths each year. Aspergillus fumigatus is an opportunistic, fungal pathogen which can lead to a variety of disease manifestations, generally termed aspergillosis and account for more than 200,000 life threatening infections annually with mortality rates of up to 95%. The occurrence of funga
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50

Gokhan, Ezgi. "The Repo-Man/PP1 complex role in chromatin remodelling, nuclear structure and cancer progression." Thesis, Brunel University, 2016. http://bura.brunel.ac.uk/handle/2438/14731.

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Repo-Man is a chromatin-associated PP1 targeting subunit that coordinates chromosome re-organisation and nuclear envelope reassembly during mitotic exit. At the onset of mitosis, Repo-Man association with the chromosomes is very dynamic; at anaphase, Repo-Man targets to the chromatin in a stable manner and recruits PP1 to de-phosphorylate histone H3 at Thr3, Ser10 and Ser28. Previous studies have suggested that CDK1 and AuroraB are the kinases responsible for the inactivation of the complex and for its dispersal at the onset of mitosis respectively. We have previously shown that the binding of
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