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Artículos de revistas sobre el tema "Rats as laboratory animals"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 30 de julio de 2024

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1

Odenweller, C. M., C. T. Hsu, E. Sipe, J. P. Layshock, S. Varyani, R. L. Rosian, and S. E. DiCarlo. "Laboratory exercise using "virtual rats" to teach endocrine physiology." Advances in Physiology Education 273, no. 6 (December 1997): S24. http://dx.doi.org/10.1152/advances.1997.273.6.s24.

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Animal experimentation is limited in many curricula due to the expense, lack of adequate animal facilities and equipment, and limited experience of the teachers. There are also ethical concerns dealing with the comfort and safety of the animals. To overcome these obstacles, we developed a "dry laboratory" using "virtual rats." The "virtual rat" eliminates the obstacles inherent in animal experimentation, such as inadequate budgets, as well as avoiding important animal rights issues. Furthermore, no special materials are required for the completion of this exercise. Our goal in developing this

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2

Gürlek, Ali. "Rats As Laboratory Animals In Chronic Studies." Plastic & Reconstructive Surgery 100, no. 6 (November 1997): 1618. http://dx.doi.org/10.1097/00006534-199711000-00052.

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3

Temoçin, Sadun, Hüseyin Beydağı, Sedat Akar, and S. Sadi Kurdak. "Exercise Methods in Small Laboratory Animals (Rats)." European Journal of Therapeutics 5, no. 2 (June 1, 1994): 247–54. http://dx.doi.org/10.58600/eurjther.1994-5-2-1080-arch.

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Lots of study about exercise were performed in recent years. Small laboratory animals, especially rats are used widely in these studies. Several exercise models about small laboratory animals were explained, and some special methodological examples used in physiological research were presented in this review.

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4

Kunstýř, I., F. Jelínek, U. Bitzenhofer, and W. Pittermann. "Fungus Paecilomyces: a new agent in laboratory animals." Laboratory Animals 31, no. 1 (January 1, 1997): 45–51. http://dx.doi.org/10.1258/002367797780600260.

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The fungus Paecilomyces has not yet been considered a health problem in laboratory animals. However, this agent known as a 'spoiler' of fruit beverages and other foodstuffs is an opportunistic pathogen especially in immunocompromised humans. Since 1985, we have isolated Paecilomyces, most probably P. variotti, from six laboratory animal species, mainly rats. In about 90% of cases the organism was localized in the respiratory tract and there are some other findings favouring the hypothesis of an airborne infection. During this long observation period no consequences for the health of rats in on

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5

Birke, Lynda. "Who—or What—are the Rats (and Mice) in the Laboratory." Society & Animals 11, no. 3 (2003): 207–24. http://dx.doi.org/10.1163/156853003322773023.

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AbstractThis paper explores the many meanings attached to the designation,"the rodent in the laboratory" (rat or mouse). Generations of selective breeding have created these rodents. They now differ markedly from their wild progenitors, nonhuman animals associated with carrying all kinds of diseases.Through selective breeding, they have moved from the rats of the sewers to become standardized laboratory tools and (metaphorically) saviors of humans in the fight against disease. This paper sketches two intertwined strands of metaphors associated with laboratory rodents.The first focuses on the i

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6

Dragan, Sergey P., Igor A. Veselovsky, Dmitriy B. Komarov, and Aleksey V. Bogomolov. "METHOD FOR FORMING BEHAVIORAL REACTIONS IN LABORATORY ANIMALS." Siberian Journal of Life Sciences and Agriculture 15, no. 4 (August 30, 2023): 11–28. http://dx.doi.org/10.12731/2658-6649-2023-15-4-11-28.

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Background. The solution of a number of applied problems requires extrapolation of the medical and biological effects of exposure to extreme physical factors from animals on humans based on the results of experimental studies of the behavioral reactions of animals under the influence of such factors. The specificity of such studies is the need for preliminary formation of the necessary behavioral responses in a large group of laboratory animals, which requires significant time costs. Purpose. The purpose of the study was to reduce the time of formation of behavioral reactions in laborato

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7

Jacob, Howard J. "Modern genetic mapping approaches in laboratory animals/rats." Journal of Experimental Animal Science 41, no. 1-2 (March 2000): 32–34. http://dx.doi.org/10.1016/s0939-8600(00)80023-1.

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8

Chechet, O. M., and V. L. Kovalenko. "Study of the safety and harmlessness of a disinfectant in laboratory animals." Journal for Veterinary Medicine, Biotechnology and Biosafety 8, no. 1-2 (May 10, 2022): 23–29. http://dx.doi.org/10.36016/jvmbbs-2022-8-1-2-4.

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The work aimed to investigate the effect of the disinfectant ‘Diolaid’ based on sodium chlorite and sodium chloride on acute toxicity indicators, as well as on blood parameters of laboratory animals. The experiments were carried out on 6-month-old clinically healthy male rats (5 groups, 6 animals in each group, n = 30) and female rats (5 groups, 6 animals in each group, n = 30) weighing 200–220 g. The drug was administered to animals intragastrically (by probe) and aerosol treatment of cells with animals was carried out. Separately we studied the skin-irritating and sensitizing action of the d

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9

Bowen, W. H., K. M. Madison, and S. K. Pearson. "Influence of Desalivation in Rats on Incidence of Caries in Intact Cagemates." Journal of Dental Research 67, no. 10 (October 1988): 1316–18. http://dx.doi.org/10.1177/00220345880670101401.

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The evidence that dental caries is an infectious and transmitted disease in rodents is unequivocal. However, the factors controlling the transmission of micro-organisms from one animal to another have not been extensively explored. Results from previous studies in our laboratory showed that desalivated animals became infected by Streptococcus sobrinus in a shorter period of time than did intact animals. Furthermore, an additional study in our laboratory showed that animals with intact salivary function caged with desalivated animals harbored more S. sobrinus immediately following establishment

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10

Smith, William. "Responses of laboratory animals to some injectable anaesthetics." Laboratory Animals 27, no. 1 (January 1, 1993): 30–39. http://dx.doi.org/10.1258/002367793781082377.

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Xylazine, ketamine, methohexitone and alphadalone/alphaxalone, were administered intraperitoneally, intramuscularly or intravenously to mice, rats, guineapigs and rabbits. Times for disappearance and reappearance of reflexes were recorded, and duration of loss of reflex. Delivering a predetermined dose gave a varying individual response, ranging from inadequate anaesthesia to death. Using reflexes to assess depth of anaesthesia was of limited value. Reflex movements to noxious stimuli generally persisted even at dose rates that caused prolonged recovery times and death. Conversely, in rats the

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11

Ujwala Ashokrao Jadhao, Chatraguna Eknathrao Lagad, and Rajesh Kundlikrao Ingole. "Laboratory animal handling techniques, basic facilities and care: A review." World Journal of Biology Pharmacy and Health Sciences 12, no. 3 (December 30, 2022): 170–82. http://dx.doi.org/10.30574/wjbphs.2022.12.3.0239.

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Animals have been utilized in pharmaceutical scientific research and development for more than 300 years. Pharmaceutical items are a must in order to treat illnesses caused by viruses, bacteria, or homeostatic imbalance, among other causes. Pharmaceuticals must be thoroughly characterized via in vitro, in vivo, and clinical trial investigations in order to be used in humans. It is essential to quantify organism's in vivo using animals whose physiology and genetics are most similar to those of humans. Common animals used for laboratory experimental research are Cats, Rats, Dogs, Mice, Guinea pi

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12

Castelhano-Carlos, Magda J., Vera Baumans, and Nuno Sousa. "PhenoWorld: addressing animal welfare in a new paradigm to house and assess rat behaviour." Laboratory Animals 51, no. 1 (July 10, 2016): 36–43. http://dx.doi.org/10.1177/0023677216638642.

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The use of animals is essential in biomedical research. The laboratory environment where the animals are housed has a major impact on them throughout their lives and influences the outcome of animal experiments. Therefore, there has been an increased effort in the refinement of laboratory housing conditions which is explicitly reflected in international regulations and recommendations. Since housing conditions affect behaviour and brain function as well as well-being, the validation of an animal model or paradigm to study the brain and central nervous system disorders is not complete without a

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13

Ushakova, Yu V., G. E. Rysmukhambetova, I. V. Ziruk, V. V. Frolov, and K. A. Grandonyan. "Establishing the safeness of gluten-free nourishment for laboratory animals." E3S Web of Conferences 222 (2020): 03013. http://dx.doi.org/10.1051/e3sconf/202022203013.

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The experiment was carried out on lab rats which had been given the gluten free nutriment in the conditions of the veterinary clinic of «Saratov State Vavilov Agrarian University». During the research, the morphological and biochemical blood analysis’ results were studied. Laboratory rats’ condition was under daily clinical monitoring as well as their weight. According to the data collected, no external signs of intoxication and death of the rats had been found during the experiment. All rats were active. The concentration of hemoglobin in the experimental group has increased by 14.33g per lit

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14

Lima, P. H., Y. Sinzato, R. Gelaleti, I. M. Calderon, M. V. Rudge, and D. Damasceno. "Genotoxicity Evaluation in Severe or Mild Diabetic Pregnancy in Laboratory Animals." Experimental and Clinical Endocrinology & Diabetes 120, no. 05 (March 15, 2012): 303–7. http://dx.doi.org/10.1055/s-0031-1299766.

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AbstractThis study aimed to evaluate the genotoxicity (DNA damage levels) in lymphocyte samples from pregnant Wistar rats with severe or mild diabetes and in whole blood samples from their newborns. Wistar female rats (1 and 90 days of age) and male rats (approximately 90 days of age) were used. The experiment consisted of 2 experimental groups (n=8 animals/group): 1) rats with severe diabetes, 2) rats with mild diabetes. For mild diabetes induction, the rats received streptozotocin (STZ) subcutaneously (100 mg/kg body weight) at day of birth, and those showing glycemia from 120 to 300 mg/dL i

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15

Townsend, P. "USE of In-Cage Shelters by Laboratory Rats." Animal Welfare 6, no. 2 (May 1997): 95–103. http://dx.doi.org/10.1017/s0962728600019564.

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AbstractThe effect of providing a shelter to single-housed rats was measured in terms of the preference shown for a cage containing a shelter compared with a barren cage, the range of behaviours performed and the apparent fearfulness of the animals. All animals showed a strong preference for cages containing a shelter and rats housed in this environment showed increased exploratory behaviour and were apparently less fearful, based on their willingness to leave the home-cage. It would seem appropriate to provide enclosed shelters within the cages of laboratory rats as a way of improving their e

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16

Uysal, Murat, Serdar Savaş Gül, Serhat Karaman, Ufuk Tas, Hilal Irmak Sapmaz, Funda Uysal, Kursad Aytekin, and Mehmet Kemal Tümer. "Caecum location in laboratory rats and mice: an anatomical and radiological study." Laboratory Animals 51, no. 3 (July 4, 2016): 245–55. http://dx.doi.org/10.1177/0023677216658916.

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Intraperitoneal (i.p.) injection is the most frequently used method for implementing parenteral therapies in rats and mice. Whether the caecum is located in the right caudal quadrant or left caudal quadrant in the abdominal cavity is not clear. For that reason, we have developed a method for identifying the location of the caecum in rats and mice and thus revealed the most reliable location for i.p. injection in these animals. Two hundred Wistar albino rats and 100 BALB/c mice were used. The location of the caecum was determined by revealing the intra-abdominal organs immediately following eut

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17

Krasnikova, E. S., R. V. Radionov, A. V. Krasnikov, and A. Yu Svetozarova. "WEIGHTINGS IN EXPERIMENTAL BLV INFECTION IN LABORATORY RATS." Scientific Life 16, no. 2 (2021): 218–28. http://dx.doi.org/10.35679/1991-9476-2021-16-2-218-228.

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The causative agent of bovine enzootic leukemia (BLV) has a tropism to lymphoid tissue and, due to the presence of these cell elements in various organs, can contribute to changes at the organ level, both due to hyperplasia and malignant proliferation of lymphoid elements, and due to inflammatory, dystrophic and atrophic processes in organs. The pathogen is able to infect heterologous organisms, in particular white laboratory rats of the Wistar line, in connection with which the goal of our studies was a comparative analysis of the vesometric characteristics of the internal organs of BLV-infec

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18

Nádeníček, Jaroslav, Eva Voslářová, Veronika Vojtkovská, Katarina Nenadović, and Vladimír Večerek. "Effects of the housing system and environmental enrichment on social dominance in laboratory male rats." Acta Veterinaria Brno 92, no. 4 (2023): 381–87. http://dx.doi.org/10.2754/avb202392040381.

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In laboratory rats, dominance manifests as agonistic behaviour that damages social bonds between individuals. In this study, the effect of the housing system and environmental enrichment on the social dominance in male Wistar rats was assessed in the social dominance tube test. Rats were housed in different housing systems (individual vs. social housing, with or without enrichment) from weaning and tested at the age of 7 weeks. In each test, two rats from different housing systems were released into opposite ends of a narrow tube and the rat that forced its opponent out of the tube was declare

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19

Makowska, I. Joanna, and Daniel M. Weary. "Assessing the emotions of laboratory rats." Applied Animal Behaviour Science 148, no. 1-2 (September 2013): 1–12. http://dx.doi.org/10.1016/j.applanim.2013.07.017.

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20

Banerjee, A. K., A. F. Angulo, A. A. Polak-Vogelzang, and A. M. Kershof. "An alternative method for the decontamination of rats carrying Mycoplasma pulmonis without the use of germfree isolators." Laboratory Animals 21, no. 2 (April 1987): 138–42. http://dx.doi.org/10.1177/002367728702100210.

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Two strains of Lewis rat were successfully freed from Mycoplasma pulmonis infection by using a combination of oral treatment with oxytetracycline hydrochloride and obtaining young by hysterectomy. Laminar flow cabinets were used to perform hysterectomies on donor animals and for rearing hysterectomy-derived animals. After thorough microbiological examination the rats were brought to the breeding colony of the Laboratory Animal Centre. Periodic laboratory tests using both cultural and enzyme-linked immunosorbent assay methods showed that the animals have remained free from M. pulmonis for the l

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21

Kashkovskaya, Lyudmila Mikhaylovna, Andrey Vladimirovich Balyshev, Vladimir Aleksandrovich Orobets, and Ivan Aleksandrovich Fedorov. "Toxicological characteristics of anticoccidial preparation Decvycox on laboratory animals." Agrarian Scientific Journal, no. 3 (March 16, 2020): 51–57. http://dx.doi.org/10.28983/asj.y2020i3pp51-57.

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The common practice in the prevention and treatment of eimeriosis in chickens is the application of anticoccidial preparations. The parameters of acute toxicity of the anticoccidial preparations Decvycox in laboratory animals were studied. It was found out that the LD50 of Decvycox with oral administration to mice and rats exceeds doses of 6579 and 7222 mg/kg of animal weight, respectively. Thus, according to the generally accepted hygienic classification, Decvycox belongs to hazard class 4 - low-hazard substances.

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22

Глухарева and E. Glukhareva. "Acute oral and cutaneous toxicities of cyflunit- flock tested on laboratory animals." Russian Journal of Parasitology 3, no. 1 (March 24, 2016): 114–18. http://dx.doi.org/10.12737/18371.

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Objective of research: to determine the toxicological properties of the preparation Cyflunit- Flock under acute experimental conditions at oral and subcutaneous administration routes to laboratory animals. Materials and methods: White outbred mice and white outbred rats of both genders were used for testing. Each dose of the preparation was tested on groups of males and females to identify the eventual sex differences in drug-responsiveness.In experiment on mice, animals were divided into 5 groups of 10 animals each.The medicine was given orally at the doses

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23

Kotsyumbas, I. Ja, O. M. Brezvyn, Y. A. Ivashkiv, H. V. Rudyk, and Ju V. Muzika. "STUDY OF THE CUMULATIVE PROPERTIES OF «INDEZ» ON LABORATORY WHITE RATES." Scientific and Technical Bulletin оf State Scientific Research Control Institute of Veterinary Medical Products and Fodder Additives аnd Institute of Animal Biology 21, no. 1 (June 1, 2020): 98–104. http://dx.doi.org/10.36359/scivp.2020-21-1.11.

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The article presents the results of the study of «Indez» disinfectant. An effective disinfectant for use in animal husbandry should be easy to use, be non-toxic, have broad bactericidal spectrum, be non-carcinogenic, have non-addictive micro-flora and provide a permanent bactericidal effect in the presence of animals, while sanitizing the air environment. «Indez» disinfectant is a small, amorphous grey powder with a specific odour, well sprayed. It is composed of triiodomethane (iodoform), zinc oxide, iron sulphate (II) (iron sulphate), copper sulphate, silicon dioxide, zeolite, active essenti

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24

Sergalieva, Mariyam U., Alexsandra A. Tsibizova, Elvira I. Abdulkadyrova, Ludmila A. Andreeva, Marina A. Samotrueva, and Nikolay F. Myasoedov. "The influence of glyprolins on the behavior of laboratory animals under experimental hyperthyroidism." Bulletin of the Russian Military Medical Academy 23, no. 4 (December 15, 2021): 179–86. http://dx.doi.org/10.17816/brmma66467.

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This study aimed to determine the peculiarities of behavioral reactions and psychoemotional status of laboratory animals in experimental hyperthyroidism conditions against the background of introducing peptides of glyproline series (selank and tripeptide Pro-Gly-Pro). All experiments were conducted on white non-linear male rats, which were divided into groups consisting of 10 individuals. The first group consisted of control rats that received intraperitoneal water for injection in equi-volume. The second group consisted of individuals with experimental hyperthyroidism modeled by intragastric

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25

Milligan, S. R., G. D. Sales, and V. J. Pocock. "A wax diet for administration of octylphenol to laboratory rodents as a tool for the investigation of oestrogenic activity." Proceedings of the British Society of Animal Science 2001 (2001): 66. http://dx.doi.org/10.1017/s1752756200004488.

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The use of controlled dietary intake for administration of environmental oestrogens to laboratory animals is essential in assessing the real threat of natural exposure to these compounds. Although human and animal exposure to environmental chemicals is mostly through diet or water, administration of these chemicals to laboratory animals is usually via injection. In this study, in order to overcome the problem of unpalatability of high doses of chemicals, a wax and a powdered diet were designed. These diets were used as vehicles for administration of the environmental oestrogen octylphenol (OP)

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26

Silva, Teane M. A., Erica A. Costa, Tatiane A. Paixão, Renée M. Tsolis, and Renato L. Santos. "Laboratory Animal Models for Brucellosis Research." Journal of Biomedicine and Biotechnology 2011 (2011): 1–9. http://dx.doi.org/10.1155/2011/518323.

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Brucellosis is a chronic infectious disease caused byBrucellaspp., a Gram-negative facultative intracellular pathogen that affects humans and animals, leading to significant impact on public health and animal industry. Human brucellosis is considered the most prevalent bacterial zoonosis in the world and is characterized by fever, weight loss, depression, hepato/splenomegaly, osteoarticular, and genital infections. Relevant aspects ofBrucellapathogenesis have been intensively investigated in culture cells and animal models. The mouse is the animal model more commonly used to study chronic infe

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27

Wuri, Rahmitiana, Aziis Mardanarian Rosdianto, and Hanna Goenawan. "UTILIZATION OF RATS AS BLUNT TRAUMA ANIMALS MODEL: A LITERATURE REVIEW." Indonesia Medicus Veterinus 10, no. 2 (March 31, 2021): 338–54. http://dx.doi.org/10.19087/imv.2021.10.2.338.

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The occurrence of contusion in humans and animals becomes an interesting study material, many researchers search and do a treatment formulation for contusion. The various effects of applying a new substance/drug to humans can be determined by studying cumulative effect of doses at the preclinical stage. The information was obtained from conducting laboratory experiments in vivo using experimental animals as a model designed in preclinical tests, such as using rats (Rattus norvegicus). So far, the development of using rat as an animal model of contusion is still very potential for further study

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28

Meanger, J. D., and R. B. Marshall. "Campylobacter jejuni infection within a laboratory animal production unit." Laboratory Animals 23, no. 2 (April 1, 1989): 126–32. http://dx.doi.org/10.1258/002367789780863637.

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A conventional laboratory animal production unit in which rats, mice, guineapigs and rabbits were bred in one building and cats maintained in a separate, but adjacent area was examined for the presence of intestinal thermophilic Campylobacter spp. Campylobacter jejuni was recovered from 18·84% of 552 animals. The infection rate was highest amongst the cats (51·7%), with rats being the second most commonly infected (23·2%), whereas only 7·7% of guineapigs and a single rabbit (1%) were positive. Campylobacter-like organisms were cultured from 10% of the mice, but these bacteria failed to grow on

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29

Lazarenko, V. A., I. S. Ivanov, A. A. Ushanov, E. S. Mishina, E. G. Obedkov, and V. S. Kostin. "Hernia or hernia Defect? Experimental herniology Models in Laboratory Animals." Innovative Medicine of Kuban, no. 3 (August 18, 2023): 114–20. http://dx.doi.org/10.35401/2541-9897-2023-26-3-114-120.

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Hernias of the anterior abdominal wall remain one of the most common surgery pathologies. There is no unified approach to modeling anterior abdominal wall hernias in the world scientific community. In order to systematize the available knowledge in this field and to contribute to the formation of a unified idea of how to create a hernia model in a laboratory animal, it seems logical to study the accumulated experience of researchers in the field of experimental herniology. We found out that hernia defects generally modeled on male laboratory rats. To understand the tissue reaction to the prost

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30

Gerunov, T. V. "IMMUNOTROPIC EFFECTS OF IVERMECTIN IN PRODUCTIVE AND LABORATORY ANIMALS." Toxicological Review, no. 1 (February 24, 2020): 49–53. http://dx.doi.org/10.36946/0869-7922-2020-1-49-53.

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The aim of this work was to identify the immunotropic effects of ivermectin in productive and laboratory animals in real and simulated conditions. The studies were carried out on hybrid pigs at the age of 144 days reared in an industrial pig complex and on Wistar rats aged 5 months with a body weight of 230 - 250 g. For the experiments there was used acaricide insecticide Ivermin (Biovet Drwalew S.A., Poland), which was administered to pigs once subcutaneously in a dose of 0,2 mg / kg and to rats in a tenfold therapeutic dose. Blood samples were taken from pigs either before the administration

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31

Kaminska, M. V. "THE COMPLEX METHOD FOR DETERMINATION OF INTESTINAL MICROFLORA COMPOSITION OF LABORATORY ANIMALS." Agriciltural microbiology 22 (December 29, 2015): 60–65. http://dx.doi.org/10.35868/1997-3004.22.60-65.

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The method of determination of qualitative and quantitative composition of intestinal microflora of laboratory animals, namely albino rats, was described. The method allows to simultaneously identify different groups of microorganisms in one sample of intestinal composition and to get a full picture of microbocoenosis within 4 days that allows to consider animal’s health, dysbiotic infringement in intestinal microflora composition and its correction with probiotic preparations.

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32

Khlebalina, A. S., S. Vl Engashev, and A. M. Lunegov. "Study of blood analysis of laboratory animals with subchronic oral toxicity of the drug Amoxiyantar." Legal regulation in veterinary medicine, no. 2 (July 21, 2023): 88–91. http://dx.doi.org/10.52419/issn2782-6252.2023.2.88.

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The article presents the results of studies of subchronic oral toxicity in laboratory animals of the new veterinary drug Amoxiantar. The studies were carried out as part of a laboratory-experimental (preclinical) study of a medicinal product with the aim of introducing it into clinical veterinary practice. Our goal was to study the effect of Amoxiantar on the hematological and biochemical parameters of the blood of laboratory animals. Three experimental groups were formed, of which two experimental and one control, consisting of white outbred rats, 10 animals each. The drug was administered to

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Zawirska-Wojtasiak, Renata, Agnieszka Fedoruk-Wyszomirska, Paulina Piechowska, Sylwia Mildner-Szkudlarz, Joanna Bajerska, Elżbieta Wojtowicz, Krzysztof Przygoński, Dorota Gurda, Wiktoria Kubicka та Eliza Wyszko. "β-Carbolines in Experiments on Laboratory Animals". International Journal of Molecular Sciences 21, № 15 (24 липня 2020): 5245. http://dx.doi.org/10.3390/ijms21155245.

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Some studies have ascribed a protective effect against neurodegenerative diseases to the β-carbolines harman (H) and norharman (NH), which occur mostly in coffee and coffee substitutes. We determined the concentrations of β-carbolines and undesirable compounds (such as acrylamide) in roasted coffee substitute ingredients and found that chicory coffee was optimal. Two in vivo experiments were conducted with seventeen-month-old male Sprague Dawley rats fed a diet with the addition of pure carboline standards in the first stage, and chicory in the second. We observed an increase in the level of H

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GOURTSAS (K.I. ΓΚΟΥΡΤΣΑΣ), K. I. "Common non infectious skin conditions of laboratory mice and rats." Journal of the Hellenic Veterinary Medical Society 50, no. 1 (January 31, 2018): 11. http://dx.doi.org/10.12681/jhvms.15693.

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Laboratory mice and rats are the most favourite animals of the researchers all over the world. Sometimes these rodents can show a number of non infectious conditions concerning their hair, skin or legs and tail. These can be alopecia, bite wounds or the shedding of their legs or tail. It is important that ordinarily there is not a pathological cause for these conditions. It is believed that the social behaviour and the enviromental conditions of the animals may play a role. Fortunately, these cases are easily encountered and so, healthy animals are ensured for every reliable research.

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Polukhina, D. N., O. A. Panova, O. P. Kurnosova, N. B. Emelyanova, N. Yu Sysoeva, A. V. Khrustalev, and L. I. Kachurina. "Experience of eradicating parasites of laboratory rats in conventional vivarium." Russian Journal of Parasitology 17, no. 1 (April 2, 2023): 151–62. http://dx.doi.org/10.31016/1998-8435-2023-17-1-151-162.

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The purpose of the research is to test different dehelminthization schemes of laboratory rats infected with cestodes Rodentolepis nana and nematodes Syphacia muris and evaluate the significance of combined environment disinfection measures. The practical experience of eradication (helminth eradication) in animals in a conventional vivarium was described.Materials and methods. Experiments were conducted to study the efficacy of anthelmintics and administration schemes against cestode and nematode infections in laboratory rats. In the first experiment, praziquantel was used at a dose of 10 mg/kg

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Harashchuk, M. I., L. M. Stepchenko, T. L. Spitsina, and V. R. Goryaniy. "Metabolism state in laboratory rats when using amaranth oil and Humilid." Theoretical and Applied Veterinary Medicine 9, no. 1 (2021): 30–34. http://dx.doi.org/10.32819/2021.91005.

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The search for new natural non-toxic biologically active substances for animals used to correct and stimulate metabolic processes, and through it the ability to control the growth and animals’ productivity, the state of their natural resistance is the main task of the present. The paper presents study results on the effect of cold-pressed amaranth oil and biologically active additive of humic nature «Humilid» when used simultaneously on the general body condition, growth indicators of laboratory rats, morphofunctional and biochemical parameters of their blood. To achieve this goal, the followi

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Stryjek, Rafał. "Devices for handling small mammals in laboratory conditions." Acta Neurobiologiae Experimentalis 68, no. 3 (September 30, 2008): 407–13. http://dx.doi.org/10.55782/ane-2008-1707.

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Wild rodents, and especially rats, are significantly more difficult to handle, maintain and breed than laboratory rats and mice. They can be characterized as more skittish, neophobic and aggressive. While establishing a breeding colony of wild Norwegian rats (Rattus norvegicus) I developed some helpful devices and I will describe them here. In this paper I also describe the techniques for transporting animals between their home cages, separating them inside cages, and catching individuals that escape. These devices do not require any home cage modification. They may be modified for size. With

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Bondarchuk, A. O., A. P. Paliy, A. P. Palii, and A. P. Aksonov. "Determination of acute toxicity of the ‘Bondarmin’ disinfectant when administered intraperitoneally to laboratory animals." Journal for Veterinary Medicine, Biotechnology and Biosafety 6, no. 4 (December 1, 2020): 25–28. http://dx.doi.org/10.36016/jvmbbs-2020-6-4-5.

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The article presents the results of the study of the acute toxic effect of the innovative disinfectant ‘Bondarmin’ (active substance — potassium peroxomonosulfate) on laboratory animals (mice, rats) are presented. Many scientific works of scientists in recent years have been devoted to the study of the toxicity of various disinfectants both in our country and abroad. However, today there are many topical issues regarding the toxicity and safety of some antimicrobials. Our work aimed to study the toxic effect on the laboratory animals and to establish the acute toxicity (LD50) of the developed

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Burman, OHP, and M. Mendl. "Long-term social memory in the laboratory rat (Rattus norvegicus)." Animal Welfare 15, no. 4 (November 2006): 379–82. http://dx.doi.org/10.1017/s0962728600030712.

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AbstractA key question in the management of group-housed captive animals is how long can an individual be removed from a social group and still be reintroduced with minimal social upheaval. In order to answer this question we require a knowledge of how long cage-mates, following a specified period of group-housing, can remember one another after separation. This issue was investigated in laboratory rats (Rattus norvegicus). Rats were group-housed for 18 days before being housed individually. One hour, 48 hr, and 96 hr after separation, they were exposed simultaneously to odour cues originating

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Malkov, S. V., A. S. Krasnoperov, O. Yu Oparina, A. I. Belousov, and I. Yu Vershinina. "Toxicological studies of additives feed endoforce multi on laboratory animals." Bulletin of NSAU (Novosibirsk State Agrarian University), no. 2 (July 26, 2023): 220–28. http://dx.doi.org/10.31677/2072-6724-2023-67-2-220-228.

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The creation of new drugs and feed additives is an urgent task that contributes to the growth of the efficiency of the livestock and poultry industries of agriculture, especially during the period of import substitution in the Russian Federation. An experimental study of possible changes in the body of laboratory animals after single or multiple uses of new feed additives is necessary for the toxicological assessment of newly created products. Single intragastric administration of feed additive Endoforce Multi containing live vegetative cells and spores of cultures: Bacillus subtilis B-5449, B

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De Almeida, Kelly Costa, Priscilla Rodrigues Câmara, Cláudia Martins Foly, Andréa Regina de Souza Baptista, Vinicius D'´Avila Bitencourt Pascoal, and Aislan Cristina Rheder Fagundes Pascoal. "Standardization of reference values of hepatic and renal biochemical markers in rats (Rattus novergicus) Wistar lineage." Concilium 23, no. 4 (March 30, 2023): 101–15. http://dx.doi.org/10.53660/clm-993-23c23.

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The biochemical parameters of laboratory animals may vary between different lineages and strains of a given species, being influenced by the microenvironment and macroenvironment of the vivarium for breeding and maintenance, as well as particularities of the method and commercial kit used in the analysis. This study aimed to determine the reference values for the hepatic and renal parameters of Unib-line Wistar rats. Forty healthy male Wistar rats were studied, weighing an average of 200 to 300g, from the Laboratory Animal Center of Federal Fluminense University. Quantitative biochemical analy

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42

Scháňková, Š., I. Langrová, I. Jankovská, J. Vadlejch, Z. Čadková, and D. Křivská. "Screening of Model Animals for Experimental Infection with Equine Cyathostomes." Scientia Agriculturae Bohemica 49, no. 1 (March 1, 2018): 17–20. http://dx.doi.org/10.2478/sab-2018-0003.

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Abstract Various laboratory animals – mice (Mus musculus) of six strains, rabbits (Oryctolagus cuniculus), guinea pigs (Cavia porcellus), rats (Rattus norvegicus), and Mongolian gerbils (Meriones unguiculatus) were experimentally infected with larvae of small strongyles (Cyathostominae), obtained from horse faeces and cultured to the infective larval stage L3. The attempt to transfer cyathostome larvae was aimed at developing a model for the investigation of different aspects of the life cycle and biology of these nematodes in the laboratory. Some animals were immunized (hydrocortisone) for th

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Varava, M. "Effects of leonardite and lignite on blood parameters in rats exposed to lead acetate." Ukrainian Journal of Veterinary and Agricultural Sciences 6, no. 2 (August 16, 2023): 14–18. http://dx.doi.org/10.32718/ujvas6-2.03.

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The study aimed to research in vivo changes in the hematological and biochemical parameters of laboratory rats' blood when they were continuously exposed to a moderate dose of lead acetate while receiving humic feed additives made of leonardite and lignite. Two-month-old white rats were used to assess the detoxifying properties of the humic compounds leonardite and lignite. The analog pair approach was used to create four groups of eight animals from 32 male laboratory rats for the study. Rats received a pre-meal injection of lead acetate at a dose of 7 mg/100 g of animal weight (1/110 LD50) u

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Refinetti, Roberto, and GJ Kenagy. "Diurnally active rodents for laboratory research." Laboratory Animals 52, no. 6 (May 4, 2018): 577–87. http://dx.doi.org/10.1177/0023677218771720.

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Although inbred domesticated strains of rats and mice serve as traditional mammalian animal models in biomedical research, the nocturnal habits of these rodents make them inappropriate for research that requires a model with human-like diurnal activity rhythms. We conducted a literature review and recorded locomotor activity data from four rodent species that are generally considered to be diurnally active, the Mongolian gerbil ( Meriones unguiculatus), the degu ( Octodon degus), the African (Nile) grass rat ( Arvicanthis niloticus), and the antelope ground squirrel ( Ammospermophilus leucurus

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Huber, L. "Amelioration of Laboratory Conditions for Pigeons (Columba Livia)." Animal Welfare 3, no. 4 (November 1994): 321–24. http://dx.doi.org/10.1017/s0962728600017085.

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AbstractLearning tests in animal psychology are highly standardized with regard to both the formulation of scientific questions and the methods employed to obtain reliable answers. The Skinnerian technique of conditioning rats or pigeons in small test chambers has established itself as the main laboratory method in this field. Despite the undeniable advantages of highly controlled and manipulated test conditions, a number of problems with respect to the welfare of the test animals arise from the standard application of this method. These problems are specified here along with the presentation

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Klaasen, H. L. B. M., J. P. Koopman, M. E. Van Den Brink, M. H. Bakker, F. G. J. Poelma, and A. C. Beynen. "Intestinal, segmented, filamentous bacteria in a wide range of vertebrate species." Laboratory Animals 27, no. 2 (April 1, 1993): 141–50. http://dx.doi.org/10.1258/002367793780810441.

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Segmented, filamentous bacteria (SFBs) form a group of bacteria with similar morphology and are identified on the basis of their morphology only. The relationships of these organisms are unclear as the application of formal taxonomic criteria is impossible currently due to the lack of an in vitro technique to culture SFBs. The intestine of laboratory animals such as mice, rats, chickens, dogs, cats and pigs is known to harbour SFBs. To see whether this extends to other animal species, intestines from 18 vertebrate species, including man, were examined. SFBs were detected with light microscopy

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Varava, M. "Effects of leonardite and succimer treatment on enzyme activity in rats exposed to lead acetate." Ukrainian Journal of Veterinary and Agricultural Sciences 7, no. 1 (March 19, 2024): 30–34. http://dx.doi.org/10.32718/ujvas7-1.05.

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The study aimed to research in vivo changes in the enzyme activity of the blood and liver of laboratory rats under continuous exposition to a moderate dose of lead acetate while receiving succimer together with humic feed additive madden out of leonardite. Two-month-old white rats were used to assess the detoxifying properties of the humic compounds leonardite and lignite. To conduct the study, a total of 32 male laboratory rats were divided into four groups, each consisting of eight animals, using the analog pair approach. Rats received a pre-meal injection of lead acetate at a dose of 7 mg/1

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Cinque, Carlo, Manuela Zinni, Anna Rita Zuena, Chiara Giuli, Sebastiano G. Alemà, Assia Catalani, Paola Casolini, and Roberto Cozzolino. "Faecal corticosterone metabolite assessment in socially housed male and female Wistar rats." Endocrine Connections 7, no. 2 (February 2018): 250–57. http://dx.doi.org/10.1530/ec-17-0338.

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Knowledge of animals’ hormonal status is important for conservation studies in wild or semi-free-ranging conditions as well as for behavioural and clinical experiments conducted in laboratory research, mostly performed on rats and mice. Faecal sampling is a useful non-invasive method to obtain steroid hormone assessments. Nevertheless, in laboratory studies, unlike other contexts, faecal sampling is less utilised. One of the issues raised is the necessity to collect samples belonging to different animals, separately. Usually, researchers using faecal sampling solve this problem through the iso

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Aprilia putri efendy, Deyke K. Baderan, and Arif Hidayat Arbie. "EFFECTS OF LOCAL ANASTESI USING LIDOCAIN OINTMENT ON WHITE RATS (RATTUS NORVEGICUS)." Journal of Health, Technology and Science (JHTS) 3, no. 1 (March 21, 2022): 1–9. http://dx.doi.org/10.47918/jhts.v3i1.262.

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This study aims to determine the effectiveness of drug administration, namely lidocaine ointment on male and female white rats (Rattus Norvegicus) as well as to see the comparison of water samples given to experimental animals and lidocaine ointment given to experimental animals and see the effects that occur when lidocaine ointment is given to the experimental animals. experimental animal. The method used is a laboratory experimental method using 20 experimental male and female white rats which were divided into 2 groups, namely the male and female rats. cold, hot sensation of pain sens

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Zenkov, K. F. "Assessment of the harmlessness of a medicinal enterosorbent based on amorphous silicon dioxide." Legal regulation in veterinary medicine, no. 2 (July 18, 2024): 81–84. http://dx.doi.org/10.52419/issn2782-6252.2024.2.81.

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Veterinary enterosorbents play an important role in veterinary practice. The aim of the study was to assess the toxicity of a sorbent based on amorphous silicon dioxide (enterosorbent ADC) obtained from rice husks, which are waste products of the rice processing industry and enterosorbent Zooverad obtained from vermiculite, on the body of laboratory rats. Nonlinear rats from the nursery of the Russian Academy of Medical Sciences "Rappolovo" were used for the experiment. The live weight of animals is 40-80 g. 3 groups of animals with 20 rats each were formed. Group No. 1 received the basic diet

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