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Artículos de revistas sobre el tema "Route du Rhum"

Autor: Grafiati
Publicado: 26 de julio de 2024
Última modificación: 31 de julio de 2025

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1

De la Giclais, Bertrand, François Duforez, Damien Leger, Nathalie De Premorel, Alexandre Dubois, and Maxime Elbaz. "Particularité du sommeil polyphasique d’après l’EEG de sommeil en mer chez 7 navigateurs de la route du Rhum." Médecine du Sommeil 12, no. 1 (2015): 44. http://dx.doi.org/10.1016/j.msom.2015.01.070.

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2

de La Giclais, B., F. Duforez, N. de Prémorel, A. Dubois, M. Elbaz, and D. Léger. "Particularités du sommeil polyphasique d’après la polysomnographie en mer chez 7 navigateurs de la route du Rhum 2014." Médecine du Sommeil 13, no. 3 (2016): 122–27. http://dx.doi.org/10.1016/j.msom.2016.07.003.

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3

Chen, BD. "In vivo administration of recombinant human interleukin-1 and macrophage colony-stimulating factor (M-CSF) induce a rapid loss of M- CSF receptors in mouse bone marrow cells and peritoneal macrophages: effect of administration route." Blood 77, no. 9 (1991): 1923–28. http://dx.doi.org/10.1182/blood.v77.9.1923.1923.

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Abstract Earlier studies suggested the existence of a blood-bone marrow barrier that significantly inhibits the transfer of plasma macrophage colony- stimulating factor (M-CSF) to responsive hematopoietic cells in vivo as indicated by its failure to induce a receptor downregulation in bone marrow cells. In this study, the effect of recombinant human interleukin-1 (rhuIL-1) was investigated. In vivo administration of rhuIL-1, either intraperitoneally (IP) or intravenously (IV), induced a rapid transient loss of M-CSF receptor binding activity in bone marrow cells, with a nadir occurring between
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4

Chen, BD. "In vivo administration of recombinant human interleukin-1 and macrophage colony-stimulating factor (M-CSF) induce a rapid loss of M- CSF receptors in mouse bone marrow cells and peritoneal macrophages: effect of administration route." Blood 77, no. 9 (1991): 1923–28. http://dx.doi.org/10.1182/blood.v77.9.1923.bloodjournal7791923.

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Earlier studies suggested the existence of a blood-bone marrow barrier that significantly inhibits the transfer of plasma macrophage colony- stimulating factor (M-CSF) to responsive hematopoietic cells in vivo as indicated by its failure to induce a receptor downregulation in bone marrow cells. In this study, the effect of recombinant human interleukin-1 (rhuIL-1) was investigated. In vivo administration of rhuIL-1, either intraperitoneally (IP) or intravenously (IV), induced a rapid transient loss of M-CSF receptor binding activity in bone marrow cells, with a nadir occurring between 2 to 4 h
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5

Jie, Junwu, and Congjin Miao. "Analysis and Selection of Shipping Route in Ocean." Journal of Physics: Conference Series 2029, no. 1 (2021): 012151. http://dx.doi.org/10.1088/1742-6596/2029/1/012151.

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Abstract This electronic document is a “live” template. Ocean navigation is a long-distance cross ocean navigation. There are three kinds of ocean routes in common use: great circle route, rhumb line route and mixed route. The great circle route is usually used when ships are sailing in the ocean, but sometimes in the mid latitude sea area, the rhumb line route is a choice in the mid latitude sea area. Combined with the calculation of a navigation example, this paper makes some analysis on the selection of ocean routes in mid latitude sea area, illustrates the advantages and disadvantages of t
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6

O'Day, SJ, SN Rabinowe, D. Neuberg, et al. "A phase II study of continuous infusion recombinant human granulocyte- macrophage colony-stimulating factor as an adjunct to autologous bone marrow transplantation for patients with non-Hodgkin's lymphoma in first remission." Blood 83, no. 9 (1994): 2707–14. http://dx.doi.org/10.1182/blood.v83.9.2707.2707.

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Abstract Recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) clearly hastens myeloid recovery in patients with relapsed hematologic malignancies undergoing autologous bone marrow transplantation (ABMT). In efforts to further improve neutrophil engraftment and shorten hospital stay in ABMT patients, rhGM-CSF was administered by a potentially more potent route (continuous infusion) to non-Hodgkin's lymphoma (NHL) patients with better BM reserve (first remission). Time to myeloid engraftment was compared with that of NHL patients treated in first remission at our institu
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7

O'Day, SJ, SN Rabinowe, D. Neuberg, et al. "A phase II study of continuous infusion recombinant human granulocyte- macrophage colony-stimulating factor as an adjunct to autologous bone marrow transplantation for patients with non-Hodgkin's lymphoma in first remission." Blood 83, no. 9 (1994): 2707–14. http://dx.doi.org/10.1182/blood.v83.9.2707.bloodjournal8392707.

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Recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) clearly hastens myeloid recovery in patients with relapsed hematologic malignancies undergoing autologous bone marrow transplantation (ABMT). In efforts to further improve neutrophil engraftment and shorten hospital stay in ABMT patients, rhGM-CSF was administered by a potentially more potent route (continuous infusion) to non-Hodgkin's lymphoma (NHL) patients with better BM reserve (first remission). Time to myeloid engraftment was compared with that of NHL patients treated in first remission at our institution on a
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8

Mustofa, Ikhsan, Susilo Toto Raharjo, Michael Yusano, and Amrul Arifin. "Risk Journey Management Strategy for Route Hazard Mapping of Tank Trucks in Fuel Distribution in the Central Java Region." International Journal of Science and Society 6, no. 4 (2024): 162–75. https://doi.org/10.54783/ijsoc.v6i4.1314.

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PT Pertamina Patra Niaga, a state-owned enterprise in Indonesia, specializes in the downstream oil and gas sector, with a primary focus on fuel distribution across the nation via land and sea. Land transportation, carried out using tank trucks, presents unique challenges due to the high risk of accidents. To address these challenges, PT Pertamina Patra Niaga conducted a Route Hazard Mapping (RHM) and Risk Journey Management (RJM) study. The study identified key factors contributing to tank truck accidents: human error, vehicle condition, and environmental factors. Mitigation strategies include
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9

Renaut, Didier. "Nouveau rapport du GIEC. La convention-cadre sur les changements climatiques. ATLAS 3 a étudié le soleil et l'atmosphère. Quand un avion en renifle d'autres. Chaos, régimes de temps et prévisibilité. Jean-Pierre Beysson nommé directeur général de MÉTÉO-FRANCE. La route du rhum 1994, ou la météorologie médiatisée." La Météorologie 8, no. 9 (1995): 88. http://dx.doi.org/10.4267/2042/51946.

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10

Saparbayeva, Nurzipa Abubakirovna. "Biological features of Rheum wittrockii Lundstr. in the natural population of the Ketpen ridge." Bulletin of the Karaganda University. “Biology, medicine, geography Series” 103, no. 3 (2021): 125–33. http://dx.doi.org/10.31489/2021bmg3/125-133.

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The article presents data on the biological characteristics of Rheum wittrockii Lundstr. on the Ketpen ridge. The aim of the study was to research the biological characteristics of the natural growth of Rh. wittrockii. Study objects are Rh. wittrockii in natural populations of the Ketpen Ridge. In June-July 2015–2017 the route-reconnaissance method of research was carried out in the northern gorges of the Ketpen ridge of the Uygur district of the Almaty region. Determination of the morphological characteristics of plant seeds was carried out according to the methodological instructions of N.L.
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11

Seminario, Valeria. "No Road to Paradise: María 's Unbuilt Infrastructure." Revista Hispánica Moderna 78, no. 1 (2025): 68–86. https://doi.org/10.1353/rhm.2025.a962253.

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ABSTRACT: This article reexamines Jorge Isaacs' María through the unexpected lens of Latin America's history of transportation infrastructure. Written while Isaacs oversaw the construction of Cauca's most coveted export road, I argue that the novel echoes broader anxieties about Colombia's inadequate transportation technologies. Efraín and María's romance—their tearful separations and longing for reunion—acquires new historical dimensions when read as superimposed over Cauca's key export route. The couple's struggle with separation underscores the urgency for infrastructure to bridge distances
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12

Hsieh, Tsung-Hsuan, Qian Meng, Bing Han, Shengzheng Wang, and Xuezhen Wu. "Optimization of Waypoints on the Great Circle Route Based on Genetic Algorithm and Fuzzy Logic." Journal of Marine Science and Engineering 11, no. 2 (2023): 358. http://dx.doi.org/10.3390/jmse11020358.

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Determining the appropriate number and position of waypoints on a great circle route (GCR) helps to shorten the sailing distance, reduce the number of course changes, and well-approximate the GCR through a small number of rhumb line (RL) legs. In this study, a genetic algorithm-based method (i.e., the GA method) is proposed to optimize the positions of waypoints on the GCR when the number of waypoints is given. Furthermore, a fuzzy logic-based evaluation method for the number of waypoints (i.e., the FL method) is proposed to judge whether to add a new waypoint or stop the process by using the
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13

Sharma, Deepika, Naveen Kumar, Tarang Mehrotra, et al. "In vitro and in silico molecular docking studies of Rheum emodi-derived diamagnetic SnO2 nanoparticles and their cytotoxic effects against breast cancer." New Journal of Chemistry 45, no. 3 (2021): 1695–711. http://dx.doi.org/10.1039/d0nj04670a.

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Green-route-bioengineered nanoparticles have received significant attention for diagnosis and treatment of cancer in the medical technology era due to their non-toxic nature, cost-friendliness, and energy efficiency.
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14

Zhang, Wenping, Jian Wang, Chen Zhang, et al. "Synergetic Protein Factors That Improve rhGM-CSF Absorption via an Oral Route Exist in Silkworm Pupae." Molecular Pharmaceutics 12, no. 5 (2015): 1347–55. http://dx.doi.org/10.1021/mp500371g.

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15

Sujantoko, M. Mustain, and B. P. P. Ekianto. "Sedimentation analysis in the shipping lanes of Tanjung Rhu Port, Belitung." IOP Conference Series: Earth and Environmental Science 1392, no. 1 (2024): 012005. http://dx.doi.org/10.1088/1755-1315/1392/1/012005.

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Abstract Ports are a vital infrastructure needed to optimize the transportation and utilization of marine resources. As an essential means, shipping lanes must be in good condition so that the sea transportation process runs smoothly. This paper analyzes the sedimentation conditions in the shipping lane at the Tanjung Rhu port in Belitung. The investigation used a numerical model with Delft3D to predict shipping channel sedimentation over 10 years. Based on the simulation results, sedimentation occurred at the mouth of the shipping channel because the current speed was low in that area. This f
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16

Grundhöfer, Petra, and Georg G. Gross. "Purification of Tetragalloylglucose 4-O-Galloyltransferase and Preparation of Antibodies against This Key Enzyme in the Biosynthesis of Hydrolyzable Tannins." Zeitschrift für Naturforschung C 55, no. 7-8 (2000): 582–87. http://dx.doi.org/10.1515/znc-2000-7-817.

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Abstract The enzyme, β-glucogallin: 1,2,3,6-tetra-O-galloyl- β-ᴅ-glucose 4-O-galloyltransferase, which catalyzes the last common step in the biosynthesis of the two subclasses of hydrolyzable tannins, i.e. gallotannins and ellagitannins, was purified 868-fold from leaves of pedunculate oak ( Quercus robur, syn. Q. pedunculata) to apparent homogeneity. Polyclonal antibodies against this pivotal enzyme were raised in rabbits and purified by protein-A chromatography, gel-filtration and affinity complexation. They were found to react specifically with acyltransferase from oak, displaying no cross-
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17

Teste, Iliana Sosa, Yuneidys Mengana Tamos, Yamila Rodríguez Cruz, et al. "Dose Effect Evaluation and Therapeutic Window of the Neuro-EPO Nasal Application for the Treatment of the Focal Ischemia Model in the Mongolian Gerbil." Scientific World Journal 2012 (2012): 1–12. http://dx.doi.org/10.1100/2012/607498.

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Cerebrovascular disease is the third leading cause of death and the leading cause of disability in Cuba and in several developed countries. A possible neuroprotective agent is the rHu-EPO, whose effects have been demonstrated in models of brain ischemia. The Neuro-EPO is a derivative of the rHu-EPO that avoids the stimulation of erythropoiesis. The aim of this study was to determine the Neuro-EPO delivery into the central nervous system (CNS) to exert a neuroprotective effect in cerebral ischemia model of the Mongolian gerbil. The Neuro-EPO in a rate of 249.4 UI every 8 hours for 4 days showed
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18

UPADHYAY, SUDHAKER, and BHABANI PRASAD MANDAL. "NONCOMMUTATIVE GAUGE THEORIES: MODEL FOR HODGE THEORY." International Journal of Modern Physics A 28, no. 25 (2013): 1350122. http://dx.doi.org/10.1142/s0217751x13501224.

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The nilpotent Becchi–Rouet–Stora–Tyutin (BRST), anti-BRST, dual-BRST and anti-dual-BRST symmetry transformations are constructed in the context of noncommutative (NC) 1-form as well as 2-form gauge theories. The corresponding Noether's charges for these symmetries on the Moyal plane are shown to satisfy the same algebra, as by the de Rham cohomological operators of differential geometry. The Hodge decomposition theorem on compact manifold is also studied. We show that noncommutative gauge theories are field theoretic models for Hodge theory.
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19

Picciariello, L., F. Ceccarelli, F. Natalucci, et al. "AB0436 EFFECTIVENESS OF BELIMUMAB IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS: A REAL-LIFE ANALYSIS." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1346.1–1346. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3040.

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BackgroundEfficacy and safety of belimumab (BLM) in Systemic Lupus Erythematosus (SLE) patients with active disease have been demonstrated by RCTs [1,2] and confirmed by several observational studies [3-8]. Most of these data have been obtained by the use of BLM intravenous formulation (IV); on the contrary, very few findings are available on the use of the drug subcutaneous formulation (SC).ObjectivesEfficacy and drug survival of BLM have been assessed in a monocentric cohort of SLE patients, exploring any difference between the two routes of administration, IV or SC.MethodsA longitudinal stu
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20

Sanchez-Bilbao, L., J. Loricera, S. Castañeda, et al. "POS0272 INTRAVENOUS VERSUS SUBCUTANEOUS TOCILIZUMAB IN A SERIES OF 471 PATIENTS WITH GIANT CELL ARTERITIS." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 379.2–380. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3260.

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BackgroundTocilizumab (TCZ) has shown efficacy in large-vessel vasculitis, including Giant Cell Arteritis (GCA) (1-3). Clinical trials with TCZ in GCA was performed with intravenous (iv) TCZ in a phase 2 trial (3), and with subcutaneous (sc) TCZ in the phase 3 GiACTA (4). However, in GCA there are no studies comparing IV vs SC TCZ.ObjectivesTo compare the efficacy of TCZ in GCA patients according to the route of administration IV-TCZ vs SC-TCZ.MethodsMulticentre study of 471 patients diagnosed with GCA and treated with TCZ. They were divided into 2 groups according to the route of administrati
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21

Wallick, S. C., I. S. Figari, R. E. Morris, A. D. Levinson, and M. A. Palladino. "Immunoregulatory role of transforming growth factor beta (TGF-beta) in development of killer cells: comparison of active and latent TGF-beta 1." Journal of Experimental Medicine 172, no. 6 (1990): 1777–84. http://dx.doi.org/10.1084/jem.172.6.1777.

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Using recombinant DNA technology, we have generated Chinese hamster ovary (CHO) cell lines that synthesize latent transforming growth factor beta 1 (TGF-beta 1) to study immune regulation by TGF-beta 1. In vitro, latent TGF-beta 1 synthesized by transfectants or added exogenously as a purified complex after activation inhibited CTL generation to a similar extent as seen with acid-activated recombinant human (rHu) TGF-beta 1. In vivo, serum from nu/nu mice bearing CHO/TGF-beta 1 tumors contained significant levels of latent TGF-beta 1 in addition to depressed natural killer (NK) activity in spl
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22

Looijen, A., E. Van Mulligen, A. Van der Helm-van Mil, and P. De Jong. "POS0669 TAPERING SUBCUTANEOUS METHOTREXATE CAUSES MORE DISEASE FLARES COMPARED TO ORAL ADMINISTRATION IN ESTABLISHED RHEUMATOID ARTHRITIS PATIENTS." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 608.1–608. http://dx.doi.org/10.1136/annrheumdis-2022-eular.571.

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BackgroundThanks to improved treatment strategies, disease remission in rheumatoid arthritis(RA) patients has become more common. Therefore, current guidelines recommend to consider tapering DMARDs, including methotrexate(MTX), in patients who are in sustained remission. Previous research has shown that subcutaneous methotrexate(MTXsc) has a better bioavailability, efficacy and tolerability in active RA than oral MTX[1]. However, these advantages might be a disadvantage when tapering of MTXsc is considered.ObjectivesTo compare the 1-year cumulative flare rates between established RA patients w
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23

KRISHNA, S., A. SHUKLA, and R. P. MALIK. "COMMENTS ON THE DUAL-BRST SYMMETRY." Modern Physics Letters A 26, no. 36 (2011): 2739–44. http://dx.doi.org/10.1142/s0217732311036899.

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In view of a raging controversy on the topic of dual-Becchi–Rouet–Stora–Tyutin (dual-BRST/co-BRST) and anti-co-BRST symmetry transformations in the context of four (3+1)-dimensional (4D) Abelian two-form and 2D (non-)Abelian one-form gauge theories, we attempt, in our present short note, to settle the dust by taking the help of mathematics of differential geometry, connected with the Hodge theory, which was the original motivation for the nomenclature of "dual-BRST symmetry" in our earlier set of works. It has been claimed, in a recent set of papers, that the co-BRST symmetries are not indepen
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24

García-Rodríguez, Julio Cesar, and Iliana Sosa Teste. "The Nasal Route as a Potential Pathway for Delivery of Erythropoietin in the Treatment of Acute Ischemic Stroke in Humans." Scientific World JOURNAL 9 (2009): 970–81. http://dx.doi.org/10.1100/tsw.2009.103.

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Intranasal delivery provides a practical, noninvasive method of bypassing the blood-brain barrier (BBB) in order to deliver therapeutic agents to the brain. This method allows drugs that do not cross the BBB to be delivered to the central nervous system in a few minutes. With this technology, it will be possible to eliminate systemic administration and its potential side effects. Using the intranasal delivery system, researchers have demonstrated neuroprotective effects in different animal models of stroke using erythropoietin (EPO) as a neuroprotector or other different types of EPO without e
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25

Shukla, A., S. Krishna, and R. P. Malik. "Augmented Superfield Approach to Nilpotent Symmetries of the Modified Version of 2D Proca Theory." Advances in High Energy Physics 2015 (2015): 1–21. http://dx.doi.org/10.1155/2015/258536.

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We derive the complete set of off-shell nilpotent and absolutely anticommuting Becchi-Rouet-Stora-Tyutin (BRST), anti-BRST, and (anti-)co-BRST symmetry transformations forallthe fields of the modified version of two(1+1)-dimensional (2D) Proca theory by exploiting the “augmented” superfield formalism where the (dual-)horizontality conditions and (dual-)gauge invariant restrictions are exploitedtogether. We capture the (anti-)BRST and (anti-)co-BRST invariance of the Lagrangian density in the language of superfield approach. We also express the nilpotency and absolute anticommutativity of the (
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26

Sadyrova, G. A., B. E. Shimshikov, B. M. Tynybekov, et al. "Ecological and biological features of some rare and endemic plant species of south-east Kazakhstan." BULLETIN of the L.N. Gumilyov Eurasian National University. Chemistry. Geography. Ecology Series 149, no. 4 (2024): 166–84. https://doi.org/10.32523/2616-6771-2024-149-4-166-184.

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The article presents the results of ecological and biological analysis of species composition of five rare and endangered endemic plant species of southeastern Kazakhstan listed in the Red Book of the Republic of Kazakhstan. The importance of this research topic is determined by the need for a comprehensive and in-depth understanding of the ecological and biological characteristics of rare plant species growing in the southeast of Kazakhstan. The studies were conducted in the southeast of Kazakhstan (Zailiysky Alatau, Ketpen), where the objects of the study were representatives of rare and end
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27

Raj, Nitish, and Prabhat Kumar. "Leveraging HDBSCAN, LSTM and R-DTW for Proactive Detection and Collision Prediction in Maritime Traffic." Defence Science Journal 75, no. 4 (2025): 490–97. https://doi.org/10.14429/dsj.20660.

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Detecting anomalies in Automatic Identification System (AIS) data is crucial for marine safety, especially with over 60,000 vessels navigating seaways at any moment. This study proposes an enhanced approach to AIS data analysis for detecting anomalous ship behaviours and predicting collisions in maritime environments. Unlike traditional methods that rely on static threshold-based rules or simpler clustering techniques, our approach integrates advanced machine learning methods like Hierarchical Density-Based Spatial Clustering of Applications with Noise (HDBSCAN) and Long Short-Term Memory (LST
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De la Torre Rubio, N., M. Pavía Pascual, J. Campos, et al. "AB1833-HPR STUDY OF THE DEMAND FOR REFERRALS FROM PRIMARY CARE TO THE RHEUMATOLOGY DEPARTMENT OF A TERTIARY HOSPITAL." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 2148.1–2149. http://dx.doi.org/10.1136/annrheumdis-2023-eular.3995.

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BackgroundEPISER study has confirmed the great burden of rheumatic diseases, which represent almost 30% of primary care medical consultations in Spain[1,2]. Electronic consultation could be an alternative response[3]as well as rheumatologist-led update programmes and joint case discussion with primary care physicians have shown to reduce the burden of care and waiting times in rheumatology units[4].ObjectivesTo analyze the demand from primary care to the rheumatology service of a tertiary hospital.MethodsRetrospective descriptive study of the data consecutively collected from 15 to 30 May 2022
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Albert, J., T. Hosey, and B. Lamoreaux. "THU0431 PEGLOTICASE RESPONSE RATE IN UNCONTROLLED GOUT PATIENTS CO-TREATED WITH METHOTREXATE: EXPERIENCE IN A COMMUNITY RHEUMATOLOGY PRACTICE." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 453.2–454. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2076.

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Background:Pegloticase is an infused biologic approved to treat uncontrolled gout. The drug is highly effective, but patients can develop anti-drug antibodies that interfere with efficacy.1Randomized clinical trials have shown that 42% of patients treated with bi-weekly pegloticase had a serum uric acid (sUA) below 6.0 mg/dl at 3 and 6 months.2Mild-to-moderate immunomodulation has been shown to lower the prevalence of anti-drug antibody formation in patients with other autoimmune diseases (rheumatoid arthritis, Crohn’s disease, juvenile idiopathic arthritis).3Cases published in the literature
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30

Masri, K., K. Winterling, and B. Lamoreaux. "THU0434 LEFLUNOMIDE CO-THERAPY WITH PEGLOTICASE IN UNCONTROLLED GOUT." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 454.3–454. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3891.

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Background:Pegloticase is a PEGylated biologic for uncontrolled gout that has well-established efficacy. However, anti-drug antibody (ADA) development causes many patients to discontinue treatment before receiving the full therapeutic course.1ADAs bind to the pegloticase molecule, leading to reduced therapeutic efficacy and discontinuation of therapy.2Emerging data indicates that co-treatment with pegloticase and immunomodulating agents may prevent ADA development, allowing more patients to receive a full course of treatment. Prior case reports describe the results of pegloticase treatment wit
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31

Laino, M., M. Enguita, S. Castañeda, et al. "POS1142 SPANISH NATIONAL REGISTRY OF BELIMUMAB IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 899.3–901. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2650.

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BackgroundBelimumab (BLM) is a monoclonal antibody that inhibits B-lymphocyte stimulating factor (BlyS) approved as a specific treatment for systemic lupus erythematosus (SLE) in 2011. We present the experience with BLM in a Spanish cohort with more than 460 patients.ObjectivesTo describe demographic characteristics, efficacy and safety of BLM in patients with SLE in Spanish population since its approval.MethodsDescriptive, retrospective, multicenter study in patients diagnosed with SLE according to EULAR/ACR 2019, SLICC and/or ACR 1997 diagnostic criteria. Data regarding SLE patients treated
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32

Syofiyardi, Syofiyardi, Riyadiyanto Riyadiyanto, and Siti Maisarah. "Biodiversity in PT Pertamina Patra Niaga Fuel Terminal Sei Siak Mor 1 Sumbagut." International Journal of Social Service and Research 2, no. 12 (2022): 1299–309. http://dx.doi.org/10.46799/ijssr.v2i12.178.

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The areas of Tanjung Rhu and Limbungan villages are areas that are bordered by the Siak river. The existence of the Siak River in the Pekanbaru community is one of the connecting routes with other areas, as well as the entry of goods from within and outside the Pekanbaru area. Where there is the main port of the Daku River which is still used for its function today as transportation access. This transportation access has an impact on river abrasion. This study aims to acknowledge biodiversity condition in PT Pertamina. This study uses descriptive qualitative methods with data collection techni
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Antonelli, David M., and Martin Cowie. "A convenient general route to a series of diphosphine-bridged heterobinuclear complexes that contain rhodium and structures of the mixed-valent complexes [RhM(CO)4(Ph2PCH2PPh2)2] (M = Mn, Re)." Organometallics 9, no. 6 (1990): 1818–26. http://dx.doi.org/10.1021/om00156a022.

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34

Hebing, R., I. Muller, M. Lin, et al. "AB0251 INCREASED ACCUMULATION OF ERYTHROCYTE METHOTREXATE POLYGLUTAMATES DURING EARLY PHASE SUBCUTANEOUS VERSUS ORAL METHOTREXATE TREATMENT OF RHEUMATOID ARTHRITIS PATIENTS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1151.1–1151. http://dx.doi.org/10.1136/annrheumdis-2021-eular.525.

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Background:Optimal dosing of methotrexate (MTX) for individual rheumatoid arthritis (RA) patients to achieve adequate disease control is an ongoing challenge. Assessment of erythrocyte MTX-polyglutamates (PGs) levels has been employed as a tool to monitor clinical response of RA patients in the first 3-12 months of treatment and MTX-PG2-4 and total MTX-PGs were associated with a lower DAS28 over 9 months.1 However, data from earlier time points, MTX-PG6 and per route of administration are unavailable.Objectives:To investigate the pharmacokinetics and -dynamics of erythrocyte MTX-PG accumulatio
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35

Hebing, R., M. Lin, E. Struys, et al. "AB0061 PHARMACOKINETICS OF METHOTREXATE POLYGLUTAMATES IN PERIPHERAL BLOOD MONONUCLEAR CELLS OF RA PATIENTS IS SIMILAR AFTER SUBCUTANEOUS OR ORAL ADMINISTRATION IN THE METHOTREXATE MONITORING (MeMo) TRIAL." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1164.2–1164. http://dx.doi.org/10.1136/annrheumdis-2022-eular.781.

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BackgroundPharmacokinetics of methotrexate (MTX) after oral and subcutaneous administration to RA patients differs: MTX levels in plasma and MTX-polyglutamate (MTX-PG) accumulation in erythrocytes are higher during equidosed subcutaneous compared to oral MTX treatment. (1,2) No data are available whether administration route of MTX differentially impacts the intracellular concentrations of MTX-PGs in peripheral blood mononuclear cells (PBMCs) during MTX therapy.ObjectivesTo investigate the pharmacokinetics of MTX-PGs in PBMCs of newly diagnosed RA patients receiving oral or subcutaneous MTX in
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36

Prendiville, J., N. Thatcher, M. Lind, et al. "Recombinant human interleukin-4 (rhu IL-4) administered by the intravenous and subcutaneous routes in patients with advanced cancer—A phase I toxicity study and pharmacokinetic analysis." European Journal of Cancer 29, no. 12 (1993): 1700–1707. http://dx.doi.org/10.1016/0959-8049(93)90108-r.

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37

Prastiyo, Imam Budy. "Upaya Peningkatan Keselamatan Operasional Transportasi Umum: Analisis Komprehensif Penyebab Kecelakaan dan Upaya Mitigasi." Jurnal Penelitian Transportasi Darat 26, no. 1 (2024): 13–26. https://doi.org/10.25104/jptd.v26i1.2327.

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TransJakarta, sistem Bus Rapid Transit (BRT) yang dimulai pada tahun 2004, telah menjadi solusi yang efektif untuk mengatasi masalah lalu lintas di Jakarta. Namun, dalam menghadapi pertumbuhan mobilitas yang terus meningkat, TransJakarta menghadapi sejumlah tantangan, terutama terkait dengan keselamatan operasional yang sering mengalami kecelakaan. Fokus penelitian ini pada PT Transportasi Jakarta/TransJakarta dengan tujuan untuk mendeskripsikan secara komprehensif gambaran kecelakaan dan upaya peningkatan keselamatan yang ditinjau dari sisi sarana, prasarana, awak, dan manajemen operasional.
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38

Rouse, P., T. Ingram, M. Standage, and R. Sengupta. "POS0207-HPR FEAR OF MOVEMENT MEDIATES THE RELATIONSHIP BETWEEN PAIN CATASTROPHISING AND PHYSICAL FUNCTION IN PEOPLE LIVING WITH AXIAL SPONDYLOARTHRITIS: A CROSS-SECTIONAL MEDIATION ANALYSIS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 329.2–330. http://dx.doi.org/10.1136/annrheumdis-2023-eular.662.

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BackgroundAxial spondyloarthritis (axSpA) typically affects the axial skeleton and sacroiliac joints causing patients to experience pain, reduced movement, and impaired physical function. A range of treatment options are available to help axSpA patients reduce pain and maintain physical function and thereby enhance health-related quality of life. The European Alliance of Associations for Rheumatology (EULAR) identified activity as integral to the management of inflammatory arthritides, however, the majority of people living with axSpA are not sufficiently active to maintain physical function [
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39

Da Silva, Daniella Matos, Eneida Janiscki Da Lozzo, Dorly de Freitas Buchi, Carolina De Oliveira, and Simone Domit Guérios. "Oral, topical, and inhalation of Calcarea carbonica derivative complex (M8) to treat inflammatory mammary carcinoma in dogs." International Journal of High Dilution Research - ISSN 1982-6206 11, no. 40 (2021): 166–67. http://dx.doi.org/10.51910/ijhdr.v11i40.594.

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Background: Inflammatory mammary carcinoma (IMC) is locally aggressive, fast growing, highly malignant tumor that affects humans and dogs. Affected dogs usually are presented with generalized edema, pain, erythema, and skin ulceration in mammary glands. Surgery is not recommended and an effective treatment has not been established [1]. Calcarea carbonica derivative complex (M8) has demonstrated anticancer properties in a murine model, by improving innate immune response against tumor cells [2]. M8 is a complex high diluted medication comprised of Calcarea carbonica 16x, Aconitum napellus 20x,
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40

Soloviev, Vladimir Olegovich. "Two Approaches to Hamiltonian Bigravity." Universe 8, no. 2 (2022): 119. http://dx.doi.org/10.3390/universe8020119.

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Bigravity is one of the most natural modifications of General Relativity (GR), as it is based on the equivalence principle. However, its canonical structure appears rather complicated because of the unusual form of the interaction between two metrics. As a consequence, there are different approaches that are difficult to compare in detail. This work is a first attempt to obtain a synthetic picture of the Hamiltonian formalism for bigravity. Here, we are trying to combine two rather different approaches to gain a binocular view of the theory. The first publications on the subject were based on
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41

Money, John. "Provincialism and The English “Ancien Regime”: Samuel Pipe-Wolferstan and “The Confessional State,” 1776–1820." Albion 21, no. 3 (1989): 389–425. http://dx.doi.org/10.2307/4050087.

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Imagine, if you will, a ship at sea. At a distance, it could be Jason and the Argonauts, or the Flying Dutchman, or even Captain Ahab. By the cut of its jib as it looms out of the mist, however, it seems rather to be a sieve, such as that in which the Jumblies once put forth. On the poop, sextant in hand, his grizzled features set in Churchillian grimace but instantly recognizable by the ancient Connecticut watchcap which tops them, stands—no, not Walter Mitty—but Hexter the Navigator. As a veteran of many earlier voyages, real and imaginary, he has a longer memory than his shipmates. He think
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42

Pendolino, M., T. Serban, D. Camellino, P. Diana, A. Giusti, and G. Bianchi. "AB0499 STEP-DOWN APPROACH IN METHOTREXATE USE FOR THE TREATMENT OF RHEUMATOID ARTHRITIS (STEMETRA): A PILOT STUDY DEMONSTRATING EFFICACY AND SAFETY OF SHORT-TERM HIGH DOSE METHOTREXATE." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1444–45. http://dx.doi.org/10.1136/annrheumdis-2023-eular.5648.

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BackgroundMethotrexate (MTX) is the cornerstone of Rheumatoid Arthritis (RA) treatment, showing a suitable efficacy-safety profile, relatively low-cost, and versatile routes and dosage administration. However, there are no clear indications yet on the optimal use of MTX in RA, whereas existing recommendations disagree on relevant aspects (eg. route, starting and maximal dose, titration increase/decrease, and intervals to monitor toxicity) [1].ObjectivesTo evaluate the efficacy and the safety of a step-down strategy to use subcutaneous (sc) MTX in patients with RA.MethodsSTEMETRA is a 16-week o
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43

Mouna, G., M. Jguirim, N. Benchekaya, et al. "AB0871 Factors associated with radiographic hip involvement in ankylosing spondylitis." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1558.2–1558. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4851.

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BackgroundHip involvement is a classic feature of ankylosing spondylitis (AS). It causes functional impairement and disability in patients with AS. Although, many studies have looked at factors associated with radiographic hip involvement, these remain debated.ObjectivesTo define the factors associated with radiographic hip involvement in patients with AS.MethodsA cross-sectional comparative study of 105 patients was performed. Hip involvement was defined as hip pain considered related to AS inflammation and confirmed radiographically. The patients were classified into two categories: (1) no h
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44

Mahroug, M., H. Azzouzi, H. Boutaibi, O. Lamkhanat, and I. Linda. "AB0274 METHOTREXATE INTOLERANCE IN MOROCCAN RHEUMATOID ARTHRITIS PATIENTS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1162.4–1163. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3315.

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Background:Methotrexate intolerance is a principal reason for treatment discontinuation, hence the interest in a more in-depth study.Objectives:We aimed to study the prevalence of methotrexate gastrointestinal intolerance and determine its associated factors in rheumatoid arthritis (RA) patients.Methods:We designed a cross-sectional study on our RA patients recruited in January 2021 at our rheumatology department. Methotrexate Intolerance Severity Score (MISS) [1], previously validated in juvenile idiopathic arthritis patients, was used to determine methotrexate (MTX) intolerance prevalence in
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45

Grassi, M., V. Giorgi, M. Nebuloni, et al. "AB0671 NO EVIDENCE OF SARS-COV-2 IN THE KNEE JOINT: A CADAVER STUDY." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1367.2–1368. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2033.

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Background:Despite the considerable research efforts being made to learn more about COVID-19, little is known about the presence of SARS-CoV-2 genetic material in biological fluids other than respiratory droplets, blood, and feces 1,2. In particular, little is known about the presence of SARS-CoV-2 in the joints either post mortem3 or in vivo4. To the best of our knowledge, only Lopéz-Gonzalez et al.5 have published a description of acute arthritides occurring during hospitalisation due to COVID-19, and they did not find any SARS-CoV-2 genetic material in the patients’ synovial fluid samples.O
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46

Gaujoux-Viala, C., E. Dernis, E. Senbel, et al. "POS0635 METHOTREXATE MAINTENANCE ONE YEAR AFTER INITIATION OF A FIRST TARGETED THERAPY: RESULTS OF THE PROSPECTIVE STRATEGE 2 STUDY." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 593.2–593. http://dx.doi.org/10.1136/annrheumdis-2023-eular.3939.

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BackgroundMethotrexate (MTX) is the first line standard of care for the management of rheumatoid arthritis (RA). In the event of an inadequate response to MTX and the presence of a poor RA prognosis factor, recommendations include initiation of biological (bDMARD) or synthetic (tsDMARD) targeted therapy in combination with MTX.ObjectivesSTRATEGE 2 aims to establish the maintenance of MTX within two years of initiating a first targeted therapy.MethodsSTRATEGE 2 is a non-interventional study including RA patients treated with MTX for at least 3 months and requiring initiation of a first b/tsDMAR
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47

Serrano-Combarro, A., B. Atienza-Mateo, N. Del-Val, et al. "AB0416 SUBCUTANEUS VS INTRAVENOUS ABATACEPT IN RHEUMATOID ARTHRITIS-INTERSTITIAL LUNG DISEASE. NATIONAL MULTICENTER STUDY OF 392 PATIENTS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1395–96. http://dx.doi.org/10.1136/annrheumdis-2023-eular.5219.

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BackgroundInterstitial lung disease (ILD) is a severe extra-articular manifestation of rheumatoid arthritis (RA). Abatacept (ABA) has demonstrated efficacy in RA-ILD[1-2].Clinical trials have shown equivalence in subcutaneous (SC) and intravenous (IV) administration of ABA for articular manifestations[3].However, it has not been studied in RA-ILD.Objectivesto compare the effectiveness of ABA in RA-ILD patients according to the route of administration (IV-ABA vs SC-ABA).MethodsNational multicenter study of RA-ILD patients on treatment with ABA. They were divided into 2 groups according to the r
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48

Simons, G., J. Veldwijk, R. Disantostefano, et al. "OP0276 PREFERENCES FOR TREATMENTS TO PREVENT RHEUMATOID ARTHRITIS: DISCRETE CHOICE SURVEY OF RHEUMATOID ARTHRITIS PATIENTS’ FIRST-DEGREE RELATIVES IN THE UNITED KINGDOM AND GERMANY." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 183–84. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1579.

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BackgroundThere is a growing research focus on the development of interventions to reduce risk of rheumatoid arthritis (RA) in at-risk individuals.(1) A recent survey of the general population asked to assume a 60% risk of RA established that hypothetical preventive treatments were acceptable to most participants.(2) However the preferences of individuals who actually have an elevated risk of RA, such as first-degree relatives (FDRs) of RA patients, are not well understood.ObjectivesTo quantify FDRs’ preferences for preventive treatments for RA.MethodsAdult FDRs in the UK and Germany were invi
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49

Vela Casasempere, P., L. Tudela, R. Caño-Alameda, and S. Gomez-Sabater. "AB0760 EVOLUTION OF PATIENTS WITH GIANT CELL ARTERITIS: BEFORE AND AFTER THE BIOLOGICAL ERA." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1586. http://dx.doi.org/10.1136/annrheumdis-2023-eular.4492.

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BackgroundGiant cell arteritis (GCA) is the most common form of systemic vasculitis. The standard treatment to induce and maintain remission of GCA is based on the use of glucocorticoids (GC), often requiring high doses and for long periods of time. It has been associated with adverse events, sometimes severe, in up to 95% of cases (fractures, diabetes mellitus, hypertension, sepsis). In 2017, the first specific drug for this entity, tocilizumab (TCZ), an anti-IL-6 antibody, was approved. To date, there are few communications in clinical practice comparing the classical treatment scheme with t
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50

Park, J. W., M. J. Kim, H. A. Kim, J. Kim, E. B. Lee, and K. Shin. "POS0628 FAILURE TO SUSTAIN TREATMENT TARGET AFTER TAPERING TOCILIZUMAB IN PATIENTS WITH RHEUMATOID ARTHRITIS: 4-YEAR LONGITUDINAL DATA FROM A NATIONWIDE COHORT." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 552.1–552. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2818.

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Background:Tapering biologic therapy after achieving clinical remission or low disease activity (LDA) has become a viable option in daily clinical practice of treating patients with rheumatoid arthritis (RA). There are yet few studies investigating its effectiveness and safety compared with those of standard biologic treatment, especially with non-tumor necrosis factor inhibitors.Objectives:To investigate the effectiveness and safety of tapering tocilizumab (TCZ) in patients with RA who attained LDA after TCZ therapy.Methods:Data were collected from a nationwide cohort of patients with RA rece
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