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Bibliografías temáticas / RPC7α

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Literatura académica sobre el tema "RPC7α"

Autor: Grafiati

Publicado: 19 de octubre de 2024

Última modificación: 31 de julio de 2025

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Artículos de revistas sobre el tema "RPC7α"

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Cheng, Ruiying, Sihang Zhou, Rajendra K C та ін. "A Combinatorial Regulatory Platform Determines Expression of RNA Polymerase III Subunit RPC7α (POLR3G) in Cancer". Cancers 15, № 20 (2023): 4995. http://dx.doi.org/10.3390/cancers15204995.

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RNA polymerase III (Pol III) subunit RPC7α, which is encoded by POLR3G in humans, has been linked to both tumor growth and metastasis. Accordantly, high POLR3G expression is a negative prognostic factor in multiple cancer subtypes. To date, the mechanisms underlying POLR3G upregulation have remained poorly defined. We performed a large-scale genomic survey of mRNA and chromatin signatures to predict drivers of POLR3G expression in cancer. Our survey uncovers positive determinants of POLR3G expression, including a gene-internal super-enhancer bound with multiple transcription factors (TFs) that

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Kessler, Alan C., and Richard J. Maraia. "The nuclear and cytoplasmic activities of RNA polymerase III, and an evolving transcriptome for surveillance." Nucleic Acids Research 49, no. 21 (2021): 12017–34. http://dx.doi.org/10.1093/nar/gkab1145.

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Abstract A 1969 report that described biochemical and activity properties of the three eukaryotic RNA polymerases revealed Pol III as highly distinguishable, even before its transcripts were identified. Now known to be the most complex, Pol III contains several stably-associated subunits referred to as built-in transcription factors (BITFs) that enable highly efficient RNA synthesis by a unique termination-associated recycling process. In vertebrates, subunit RPC7(α/β) can be of two forms, encoded by POLR3G or POLR3GL, with differential activity. Here we review promoter-dependent transcription

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Cheng, Ruiying, and Kevin Van Bortle. "RNA polymerase III transcription and cancer: A tale of two RPC7 subunits." Frontiers in Molecular Biosciences 9 (January 12, 2023). http://dx.doi.org/10.3389/fmolb.2022.1073795.

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RNA polymerase III composition is shaped by the mutually exclusive incorporation of two paralogous subunits, RPC7α and RPC7β, encoded by genes POLR3G and POLR3GL in vertebrates. The expression of POLR3G and POLR3GL is spatiotemporally regulated during development, and multiple reports point to RPC7α-enhanced Pol III activity patterns, indicating that Pol III identity may underly dynamic Pol III transcription patterns observed in higher eukaryotes. In cancer, upregulation of POLR3G, but not POLR3GL, is associated with poor survival outcomes among patients, suggesting differences between RPC7α a

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Van Bortle, Kevin, David P. Marciano, Qing Liu, et al. "A cancer-associated RNA polymerase III identity drives robust transcription and expression of snaR-A noncoding RNA." Nature Communications 13, no. 1 (2022). http://dx.doi.org/10.1038/s41467-022-30323-6.

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AbstractRNA polymerase III (Pol III) includes two alternate isoforms, defined by mutually exclusive incorporation of subunit POLR3G (RPC7α) or POLR3GL (RPC7β), in mammals. The contributions of POLR3G and POLR3GL to transcription potential has remained poorly defined. Here, we discover that loss of subunit POLR3G is accompanied by a restricted repertoire of genes transcribed by Pol III. Particularly sensitive is snaR-A, a small noncoding RNA implicated in cancer proliferation and metastasis. Analysis of Pol III isoform biases and downstream chromatin features identifies loss of POLR3G and snaR-

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Tesis sobre el tema "RPC7α"

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Lata, Elisabeth. "L’isoforme embryonnaire de l’ARN polymérase III humaine : son rôle dans la transformation tumorale et l’établissement de métastases." Electronic Thesis or Diss., Bordeaux, 2024. http://www.theses.fr/2024BORD0168.

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L'ARN polymérase (Pol) III transcrit des petits ARN non-codants qui sont essentiels pour la cellule. Chez la plupart des vertébrés, il existe deux isoformes de la Pol III selon l’incorporation de la sous-unité RPC7α ou RPC7β. Alors que RPC7β est ubiquitaire, RPC7α est exprimée dans les cellules souches embryonnaires et certaines cellules tumorales. En particulier, RPC7α est surexprimée dans des échantillons cliniques et des lignées cellulaires de cancer du sein triple négatif (CSTN). La suppression de RPC7α dans la lignée CSTN MDA-MB-231 inhibe la croissance tumorale et la formation de métasta

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Capítulos de libros sobre el tema "RPC7α"

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"RPC7 Specification relating to the execution of the isothermal relaxation test on prestressing steel." In RILEM Technical Recommendations for the testing and use of construction materials. CRC Press, 1994. http://dx.doi.org/10.1201/9781482271362-174.

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