Literatura académica sobre el tema "Sebastic myth"

<p>O artigo faz um breve histórico do sebastianismo em Portugal, para depois avaliar as versões do mito sebástico, centrandose na obra de Plínio Salgado. A presença do mito na literatura brasileira é localizada nas seguintes obras: no <em>Dicionário de Folclore Brasileiro</em>, de Câmara Cascudo, no romance <em>O Esperado </em>e mais claramente no romance histórico <em>A Voz do Oeste</em>, texto em que o sebastianismo se torna também um mito fundador do Brasil.</p> <p>The article synthetizes a brief history of sebastianism in Portugal, and then analises the versions of “sebastic myth”, based on Plínio Salgado’s works. The presence of this myth in brazilian literature is confirmed by the following works: The <em>Folcloric Dictionary of Brazil</em>, from Câmara Cascudo, a romance entitled <em>O Esperado, </em>and the historic fiction entitled <em>A Voz do Oeste</em>, a forgotten text where the Sebastianism turns into a foundation myth of Brazil.</p>

ResumoEste artigo analisa o conceito de mito pessoal e seus desdobramentos em duas performances teatrais, Sebastian e Cura. Utiliza como base teórica os estudos do mito de Mircea Eliade, os estudos da psicologia profunda em sua relação com os conteúdos mitológicos de Carl Gustav Jung e seus continuadores e os escritos de Grotowski. Propõe a partir do mito pessoal a instauração de uma zona inconsciente de comunicação entre o performer e as testemunhas por via da infecção psíquica.AbstractThis article analyzes the concept of personal myth and its ramifications in two theatrical performances, Sebastian and Cura. It uses as theoretical base the studies of the myth of Mircea Eliade, the studies of analytical psychology in its relation with the mythological contents of Carl Gustav Jung and its followers and the writings of Grotowski. It proposes from the personal myth the establishment of an unconscious zone of communication between the performer and the witnesses through the psychic infection.

Abstract MYH-9 related platelet disorders are inherited macrothrombocytopenias. Before the genetic cause was identified, four overlapping syndromes (May-Hegglin, Epstein, Fechtnerand Sebastian syndrome) described the additional clinical manifestations in MYH-9 disorders including renal failure, hearing loss, pre senile cataract and inclusion bodies in leucocytes that are present in different combinations. The MYH-9-gene codes for the cytoplasmic contractile protein non muscular myosin heavy chain IIA, present in several tissues, which explains the additional symptoms. The bleeding tendency is usually mild to moderate but rarely, thrombotic complications are also seen (1). We report on the thrombin generation potential (ETP) in MYH9 patients with and without arterial thrombosis. In the first family (family A) 4 members were evaluated: a 51 year old woman (platelet count 36), her 24 year old daughter (platelet count 46), and the brother of the woman (57 years; platelet count 39) and his 30 year old son (platelet count 44). All four were affected by MYH-9 disorder with macrothrombocytopenia and inclusion bodies in the leucocytes and a 5521G>A mutation, causing Glu1841Lys. 3 of them had a moderate bleeding tendency [ISTH /SSC bleeding scores 9, 13, 4 where <4 is normal) (3)] and in the 51 year old women and her brother, renal insufficiency and hearing loss were already present. Both patients had an arterial thrombosis (myocardial infarction and pons infarction respectively) before 50 year of age. Both showed hyperlipidemia and hyperhomocysteinemia. In the second family (Family B) macrothrombocytopenia and small to medium size inclusion bodies in the leucocytes were found in the mother (38 years; platelet count 36) and the daughter (age15 years, platelet count 46) caused by a c. 4679 T>G mutation resulting in p.Val1560Gly. Their bleeding tendency was mild (bleeding scores 4 and 3 respectively). Thrombelastography (ROTEM) was normal in all five individuals. ETP was seen to be below the normal range in family B. However, in family A, the two members affected by thrombosis had a normal ETP (Fig 1), indicating that other factors compensated for the low platelet count and clinically even led to a breakthrough of arterial thrombosis despite the low platelet count. We suggest that other centers also assess the ETP in their MYH-9 patients according tour protocol to gather data on the potential association of the ETP with the phenotype. References Althaus K, Greinacher A: MYH-9 Related Platelet Disorders: Strategies for Management and Diagnosis. Transfus Med Hemother. 2010 October; 37(5): 260–267. Girolami A , Vettore S, Bonamigo E, Fabris F: Thrombotic events in MYH9 gene-related autosomal macrothrombocytopenias (old May–Hegglin, Sebastian, Fechtner and Epstein syndromes) J Thromb Thrombolysis. 2011 Nov;32(4):474-73. Rodeghiero F, Tosetto A, Abshire T et al.; ISTH/SSC Joint VWF and Perinatal/Pediatric Hemostasis Subcommittees Working Group. ISTH/SSC bleeding assessmenttool: a standardizedquestionnaire and a proposal for a newbleedingscore for inherited bleeding disorders. J Thromb Haemost 2010; 8: 2063–5. Figure 1. Endogenous thrombin potential in two families with MYH-9 related disease Figure 1. Endogenous thrombin potential in two families with MYH-9 related disease Thrombin generation was performed on frozen platelet rich plasma on 5 members from two different families (family A and B) with MYH-9 related disease. Two members in the first family (A:1 and A:2) had a previous arterial thrombosis (pons infarction and myocardial infarction, respectively, marked with a star). Disclosures No relevant conflicts of interest to declare.

The advantage of presence learning is the ability to spontaneously discuss issues and problems with students face to face. Individual learning can be improved by changing teaching methods, for example through project work or tele -tutoring. by combining presence learning with phases of e-learning and also intensive telephone counselling. The following question is the focus of the report: What guiding principles for learning should the teachers at schools or universities stri ve for in the digital age and how can they implement these guidelines in the work assignments? "The belief that education can, in any case, be replaced by a computer program is a myth. Human contact and mentoring make a significant difference in the learning outcomes", says Sebastian Thrun (Professor at Stanford University and vice president of Google). He looks at both educational traditions, which see the trust and the relationship between the teachers and the pupils or students as the basis of learning, as well as at the results of empirical research on learning. "Even for the digital technology and new media the educational primacy applies: Man is and remains the teacher of man" (Lankau, 2014).

In 1979, during his continuing excavation of the city of Aphrodisias, Professor K. T. Erim discovered a large temple and sanctuary complex dedicated to Aphrodite and the Julio-Claudian emperors (theTheoi Sebastoi). It had a remarkable sculptural display of which much has survived—there are about eighty relief panels. The complex would probably have been called a Sebasteion: we know from an unrelated inscription that there was one at Aphrodisias. It is of great interest to both the historian and art-historian of the early empire, giving a rare combination of buildings, sculpture, and inscriptions from a unified excavated context and providing an unrivalled picture of the physical setting of the imperial cult in a Greek city. The sculptured reliefs give a great range and combination of iconography quite unexpected in such a context—mythological, allegorical, and imperial. The myth panels seem to offer a missing link between the iconographic repertoire of the Hellenistic world and that used under the Roman empire, while the allegorical and imperial panels give a detailed plcture of the emperor and Rome as seen from the Greek East that is not available elsewhere.

Abstract It has been demonstrated that MYH-9 (non-muscle myosin IIA) is responsible for the hereditary macrothrombocytopenia, such as May-Hegglin Anomaly (MHA), Fechtner syndrome (FS) and Sebastian syndrome (SS). We identified the E1841K mutation of MYH-9 gene of a patient with May-Hegglin Anomaly. Immunofluorescent staining of her peripheral blood smear samples revealed that non-muscle myosin IIA and actin filaments were co-localized at the Döhle-like inclusion bodies of neutrophils. To investigate the mechanism by which the E1841K mutation causes the phenotype of MHA, we first expressed GFP-tagged wild type and E1841K mutant MYH-9 cDNA in NIH3T3 cells. The mutant was able to form filaments and some inclusion bodies such as Döhle-like bodies, although it seemed to make no influences on the shape of the fibroblasts. Next we expressed the GFP-tagged wild and E1841K mutant MYH-9 in HEL cells and induced differentiation with TPA. HEL cells expressing the E1841K mutant failed in full differentiation. They could not produce the proplatelet-like projections as the cells overexpressing wild type of MYH-9 did. These results demonstrate that overexpression of this mutant can induce some phenotype similar to MHA. To clarify what molecular characteristics of the mutant myosin can cause the MHA phenotype, we expressed the recombinant wild and mutant proteins of non-muscle myosin IIA using Baculo-virus system. The mutant myosin failed to dissolve even in high ionic strength, suggesting this mutant can assemble in cytoplasm even under the condition, in which wild type myosin changes the conformation and exchanges dynamically assembly to disassembly. Next we induced myosin filaments in HEL cells by over-expressing the mutant of myosin light chain (DD mutant), which mimics the double-phosphorylated form. The DD mutant of myosin light chain also inhibited the proplatelet-like projections. Moreover silencing of MYH-9 gene with siRNA could have no inhibitory effects on the differentiation of HEL cells, producing rather more proplatelet-like projections than the control. These results indicated that filament formation of myosin is not critical for proplatelet-like projections, but disassembly of myosin is rather essential. Collectively, the E1841K mutant inhibits the disassembly of myosin to prevent the proplatelet-like formation of HEL cells, and the assembled myosin forms the Döhle-like inclusion bodies probably with actin filaments.

Abstract Introduction: Myosin-heavy chain 9 (MYH9)-related platelet disorders are a group of rare inherited thrombocytopenias, encompassing four syndromes, such as May-Hegglin anomaly, Epstein syndrome, Fechtner syndrome and Sebastian platelet syndrome. Typically diagnosed in adulthood, this disorder presents with chronic thrombocytopenia in all affected individuals with varying bleeding tendencies. Other clinical manifestations may include nephritis leading to end-stage renal disease, sensorineural hearing impairment and presenile cataracts. It is often misdiagnosed as autoimmune thrombocytopenia, which can lead to inappropriate treatment with corticosteroids or intravenous immunoglobulin for many years before the correct diagnosis is made.1 This case report describes the unique role of a pediatric hematologist to facilitate multidisciplinary care and services for a child diagnosed with MYH9-related disorder and illustrates the complex health care needs of this rare diagnosis in the pediatric populations. Case description: A 4-year-old girl of Mexican origin with a history of bilateral hearing loss and speech delay was first evaluated by audiology. Upon referral for a genetic evaluation, she was incidentally found to have asymptomatic thrombocytopenia. In the next four months, she received an extensive hematologic and infectious disease workup for the unexplained thrombocytopenia, while she was treated simultaneously for immune thrombocytopenia with corticosteroids or intravenous IgG. Neither of the interventions helped to normalize her persistently low platelet count (6,000-31,000), but instead led to sporadic intervals of undesirable weight gain and mood irritability. Further genetic testing with whole genome sequencing revealed a heterozygous pathogenic variant of MYH-9 mutation in the patient, who inherited the polymorphism from her father. Specifically, her variant exhibits complete penetrance for early-onset renal failure. As a result of the patient's platelet disorder and her frequent clinic visits to hematology, a close physician-patient relationship was developed thereafter. Her pediatric hematologist assumes the role of a primary care provider and coordinates multiple specialist visits to address her complex health care issues, including general pediatrics, speech therapy, audiology, otolaryngology, nephrology and medical genetics. Longitudinal care for this patient is mostly supportive: (1) platelet transfusion is required if she experiences any prolonged bleeding episodes; (2) prophylaxis with desmopressin is provided for dental and surgical procedures; (3) parents are counseled on child safety and limitations on major contact sports. Lastly, due to the identification of a pathogenic variant in both the patient and father, patient's brother and sister are both at increased risk of inheriting the platelet disorder. In our patient's case, since her family is limited by financial means for an evaluation with molecular testing, her siblings' platelet counts and sizes can be assessed instead with a CBC and peripheral blood smear. Discussion: The complexity of an inherited hematologic disorder involves multidisciplinary, longitudinal and lifelong care for optimal health care delivery and improved clinical outcomes. When approaching a pediatric patient diagnosed with a rare platelet disorder, the role of a hematologist becomes essential to be the primary care provider and to coordinate specialist visits for the patient without delays. Efficient care coordination with a focus on the patient's needs can avoid unnecessary duplication of tests and services.2 Children affected by rare genetic disorders, such as MYH-9 disorders, have complex unmet health needs and frequently experience unique barriers to care. Longitudinal surveillance is necessary to assess the progress of the MYH9 disease, and supportive care should be provided accordingly. References: Althaus, Karina, Greinacher, Andreas. MYH-9 Related Platelet Disorders: Strategies for Management and Diagnosis. Transfus Med Hemother, 2010 Lippe, Charlotte Von Der, et al. "Living with a Rare Disorder: a Systematic Review of the Qualitative Literature." Molecular Genetics & Genomic Medicine, vol. 5, no. 6, 2017, pp. 758-773., doi:10.1002/mgg3.315. Disclosures No relevant conflicts of interest to declare.

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This research turns to a historical - cultural phenomenon whose importance is reflected in Lusophone countries: the myth of King Dom Sebastião. The Sebastianism crossed centuries and migrated from Portugal to scholarly and popular traditions, as occurred in northeastern Brazil. The analysis undertaken in this investigation seeks to situate the sebástic myth on imagination light in two literary works: Message from Fernando Pessoa, and The Stone Prince of the Kingdom and the blood of the back and forth from Ariano Suassuna . In Fernando Pessoa‟s, there is the presence of a mith closer to its original context and more orthodox appearance. In Ariano Suassuna‟s , there is a hybridized myth, amalgamated in diverse socio- cultural context and enriched by popular tradition of a very singular Brazil : the narratives of musical literature , the woodcut , the outbursts , the popular poetry , the legends of country man . The myth is therefore investigated in some of its theoretical aspects as well as the theory of fictional Gilbert Durand, whose methodology lies the comparative study between the literary works. The mythlogy of Durand, through mythcriticism, provides the concepts that will be used in this approach a fascinating journey : the sebastic myth, which is historical, cultural, political , and above all in this research , a literary mot of the richest in Lusophone traditions .
Esta pesquisa volta-se para um fenômeno histórico-cultural cuja importância é patente nos países lusófonos: o mito do rei Dom Sebastião. O sebastianismo atravessou séculos e migrou de Portugal para tradições eruditas e populares, como ocorreu no Nordeste do Brasil. A análise empreendida nessa investigação busca situar o mito sebástico à luz do imaginário em duas obras literárias: Mensagem, de Fernando Pessoa, e A Pedra do Reino e o Príncipe do sangue do vai-e-volta, de Ariano Suassuna. Em Fernando Pessoa, há a presença de um mito mais próximo do seu contexto original e de aspecto mais ortodoxo. Já em Ariano Suassuna, há um mito hibridizado, amalgamado em contexto sócio-cultural diverso e enriquecido pela tradição popular de um Brasil bastante singular: as narrativas da literatura de cordel, a xilogravura, os repentes, a poesia popular, as lendas do homem sertanejo. O mito é, portanto, investigado em algumas de suas vertentes teóricas, assim como a teoria do imaginário de Gilbert Durand, em cuja metodologia se assenta o estudo comparativo entre as obras literárias. A mitodologia de Durand, por meio da mitocrítica, fornece os conceitos que serão utilizados nesta abordagem de um itinerário fascinante: o mito sebástico, que é histórico, cultural, político e, sobretudo nesta pesquisa, um mote literário dos mais ricos nas tradições lusófonas.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico
This survey intends to elaborate a cartography on the cultural fenomenum called sebastianism. On this way, the study verifies which components assure its permanence in a certain period of time and which strengths allow its update along time and places. It also has the intention to investigate aspects of the myth s transmission and how the communication and translation processes on the delighted figure of the king of Portugal Dom Sebastian occur. All these procedures are linked to a virtual trip of the mythic king, Desired and Covered king, presented in the popular religiousty, in oral speech, in rebellious popular movements of messianic character and in artistic works. Besides the places where he passed and still passes through, the study also shows Dom Sebastian s presence in the media, such a mewspapers and television programs and its important passage on the great brazilian spectacle called Carnival
Esta pesquisa pretende elaborar uma cartografia do fenômeno cultural chamado sebastianismo. Desta forma, estaremos verificando que componentes garantem sua permanência em um dado tempo/espaço, e quais as potências que permitem sua atualização em diversas épocas e lugares. Busca-se, ainda com isso, investigar aspectos da transmissão do mito e como se dão os processos comunicacionais e tradutórios envolvendo a figura encantada do rei Dom Sebastião de Portugal. Todos estes procedimentos estão ligados com uma viagem virtual do rei mítico, Desejado e Encoberto, que se apresentará na religiosidade popular, em relatos orais, em movimentos populares rebeldes de cunho messiânico e em obras artísticas. Além destes espaços por onde trafegou e ainda trafega, iremos conferir também a presença de Dom Sebastião nas mídias, como no jornal impresso e em programas televisivos, além de sua importante passagem pelo grande espetáculo brasileiro chamado Carnaval

Cette dissertation propose une analyse, de longue durée, des perceptions polémiques du caractère, de l'action et du rôle des Jésuites dans les différents contextes de l'histoire du Portugal. Ces perceptions configurent une image qui a gagné des contours mythifiants, particulièrement à partir du gouvernement du Premier Ministre de D. Joseph I (1750-1777). Le marquis de Pombal est ici considéré comme le fondateur du mythe de la Compagnie de Jésus au Portugal. Cependant, il n'est pas facile de comprendre les origines, la dimension, l'impact, les fonctionnalités et la signification de ce myhte noir dans la culture et la mentalité portugaises si nous ne tenons pas compte des antécédents de ce processus d'engendrement d'une imagerie mythique et de sa réception et recréation ultérieures. Pour cela, notre recherche herméneutique insère la base pombaline du mythe jésuite dans une perspective temporelle plus large; cette démarche nous a permis d'apprécier la genèse, la formation et l'évolution du mythe, par le fait d'englober plus de quatre siècles d'histoire
The present dissertation proposes a long duration analysis of polemic perception of the Jesuits in different chronological points of the history of Portugal. Their character, performance and role have shaped and image that gained mythical proportions, especially after Marquës de Pombal tern as Prime-Minister to king José I (1750-1777). Pombal is here studied as the founder of th myth of the Society of Jesus in Portugal. However, in order to understand the roots, dimension, impact, functions and meaning of this dark myth in Portuguese culture and mentality, we have to take into account the antecedents of this process of creation, reception and further recreation of mythical imagery. Therefore, the research inserts Pombal's foundation of the Jesuit myth into a broader time spam, which allows us to appreciate its genesis, growth and mythical evolution, for more than four centuries of history

This dissertation examines theatre and film in Ireland between 1988 and 2005, focusing on the plays of Sebastian Barry and Marina Carr, as well as a select group of films from this period. Employing a method of analysis that couples close-readings with attention to socio-cultural context, aesthetic form, and issues of representation, the dissertation demonstrates how theatre and film work to complicate conventional Irish historical narratives and thereby encourages a reassessment of contemporary constructs of Irish identity. The introduction provides a contextual framework for significant contemporaneous social, cultural and economic changes in Ireland, and includes a case study of ‘The Spire,’ a monument unveiled on Dublin’s central boulevard in 2003, which I argue is the architectural metonym for the transitional nature of Celtic Tiger Ireland. The case study explores the aesthetics of the monument, as well as the politicised public debate that ensued, and thereby provides a snapshot of issues relevant to the readings pursued in dissertation’s remaining chapters. The discussion of Sebastian Barry’s ‘family plays’ reveals the playwright’s effort to refuse traditional binary conceptions of identity and to proffer, instead, a dramatic landscape that similarly refuses to allow conflict to dominate. Barry’s use of a non-conflictual dramatic form supports his narrative interest in compassion and peaceful resolution, and provides a model for living with otherness that could prove useful in an increasingly diverse and globalised Ireland. Marina Carr’s plays share Barry’s desire to represent aspects of Irish character anew, but they also dramatise how cultural transitions are difficult and never linear, and how the conventional pull of memory and the past has a residual presence in the ‘new’ Ireland. Taken together, these chapters reveal Barry’s hopefulness as an antidote to Carr’s tragic endings. The final chapter provides close readings of several ‘Celtic Tiger’ films, arguing that the representation of landscape is the key lens through which Irish film communicates shifting images of Irish identity. A cycle of films from the first years of the new millennium ekes out a space for new modes of representation through a critical dialogue with major tropes in Irish film history.