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Tesis sobre el tema "SgA protein"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 8 de febrero de 2022

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1

Cordeiro, Melina Aparecida 1984. "Fimbria curli : adesão de Escherichia coli associada à cistite humana em células de carcinoma de bexiga humana (HTB-9)." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317301.

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Orientador: Tomomasa Yano<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-27T06:09:15Z (GMT). No. of bitstreams: 1 Cordeiro_MelinaAparecida_M.pdf: 3889960 bytes, checksum: 3e92b071b7e108ebb8bff09fe751b180 (MD5) Previous issue date: 2015<br>Resumo: O Resumo poderá ser visualizado no texto completo da tese digital<br>Abstract: The Abstract is available with the full electronic digital document<br>Mestrado<br>Microbiologia<br>Mestra em Genética e Biologia Molecular

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2

Voll, Sarah. "Functional Genetic Analysis Reveals Intricate Roles of Conserved X-box Elements in Yeast Transcriptional Regulation." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/30168.

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Understanding the functional impact of physical interactions between proteins and DNA on gene expression is important for developing approaches to correct disease-associated gene dysregulation. I conducted a systematic, functional genetic analysis of protein-DNA interactions in the promoter region of the yeast ribonucleotide reductase subunit gene RNR3. I measured the transcriptional impact of systematically perturbing the major transcriptional regulator, Crt1, and three X-box sites on the DNA known to physically bind Crt1. This analysis revealed interactions between two of the three X-boxes i

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3

Olsson, Björne. "Protein Expression in Baltic Sea Blue Mussels Exposed to Natural and Anthropogenic Stress : The use of stress inducible proteins in ecotoxicological studies." Doctoral thesis, Stockholm University, Department of Systems Ecology, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-542.

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<p>The focus of this thesis is the early detection of stress in the environment. It has been proposed that studies on the cellular level would detect stress reactions earlier in time compared to common physiological methods. In a series of experiments we investigated how different stress factors, both natural and introduced by man, affect levels of stress proteins. One- and two-dimensional gels were used to determine individual proteins and families of proteins. The two-dimensional gels were also used in a proteomic approach, were the presence and absence of proteins after treatment was observ

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4

Olsson, Björne. "Protein expression in Baltic Sea blue mussels exposed to natural and anthropogenic stress : the use of stress inducible proteins in ecotoxicological studies /." Stockholm : Dept. of Systems Ecology, Stockholm University, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-542.

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5

Lannergård, Anders. "Serum Amyloid A Protein (SAA) in Healthy and Infected Individuals." Doctoral thesis, Uppsala University, Department of Medical Sciences, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5774.

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<p>Serum amyloid A protein (SAA) is an acute phase protein that has recently gained increasing interest as a potential marker for disease and treatment monitoring. We investigated SAA and CRP levels in (a) patients with various common infectious diseases (n=98), (b) patients with pyelonephritis (n=37) versus patients with cystitis (n=32), (c) healthy individuals of varying ages (n=231), (d) very immature newborn infants with or without nosocomial infections (NIs) (n=72) and (e) patients with bacterial infections treated with cefuroxime (n=81). </p><p>SAA significantly correlated with CRP in vi

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6

Shea, Laura R. "Identification of the Sea Urchin Egg Myosin Binding Protein Gene." Youngstown State University / OhioLINK, 1999. http://rave.ohiolink.edu/etdc/view?acc_num=ysu999192081.

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7

Thompson, Luke. "The identification and investigation of neurochondrin as a novel interactor of the survival of motor neuron protein, through analysis of the interactomes of Sm family proteins and cell fractionation." Thesis, University of St Andrews, 2018. http://hdl.handle.net/10023/16154.

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Spinal Muscular Atrophy (SMA) is a neurodegenerative, inherited disease caused by an insufficient amount of functional Survival of Motor Neurone protein (SMN), though the exact mechanism underlying this is not fully understood. The primary function of SMN is assembling a ring of Sm proteins around small nuclear RNA (snRNA) in an early, cytoplasmic stage of small nuclear ribonucleoprotein (snRNP) biogenesis, a process essential in eukaryotes. SMN, together with several mRNA binding proteins, has been linked to neural transport of mRNA towards areas of growth in Motor neurons for local translati

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8

Sullivan, Katherine B. "Replacement of fish meal by alternative protein sources in diets for juvenile black sea bass." View electronic thesis, 2008. http://dl.uncw.edu/etd/2008-3/sullivank/katherinesullivan.pdf.

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9

Shi, Dingding. "Defining the Roles of p300/CBP (CREB Binding Protein) and S5a in p53 Polyubiquitination, Degradation and DNA Damage Responses: A Dissertation." eScholarship@UMMS, 2010. https://escholarship.umassmed.edu/gsbs_diss/452.

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p53, known as the “guardian of the genome”, is the most well-characterized tumor suppressor gene. The central role of p53 is to prevent genome instability. p53 is the central node in an incredibly elaborate genome defense network for receiving various input stress signals and controlling diverse cellular responses. The final output of this network is determined not only by the p53 protein itself, but also by other p53 cooperating proteins. p300 and CBP (CREB-Binding Protein) act as multifunctional regulators of p53 via acetylase and ubiquitin ligase activities. Prior work in vitro has shown th

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10

Lannergård, Anders. "Serum amyloid A protein (SAA) in healthy and infected individuals /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5774.

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11

Thapaliya, Arjun. "Biophysical studies of SGTA, a protein involved in quality control." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/biophysical-studies-of-sgta-a-protein-involved-in-quality-control(e0ec310c-48cf-41ec-8313-dd8f47f48709).html.

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Protein quality control mechanisms are vital in maintaining correct levels of functional proteins in a crowded intracellular milieu. These mechanisms recognise proteins in their non-native state and triage such candidates for either rescue, or channel them towards pathways that lead to their degradation. In the case of secretory and membrane proteins that mislocalize to the cytosol (MLPs), and of newly synthesised tail-anchored (TA) membrane proteins, their exposure of otherwise buried hydrophobic residues necessitates a mechanism of shielding such residues from the aqueous cytoplasm. This tas

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12

Vrable, David Joseph. "A recombinant GST-EMBP440 fusion protein from sea urchin embryos that has myosin binding capabilities /." Connect to online version, 1997. http://hdl.handle.net/1989/3741.

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13

Montpetit, Isabelle. "Localization and characterization of an ectodermal protein of sea urchin embryos." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=59519.

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In the urchin Strongylocentrotus purpuratus, the expression of the Spec3 gene is associated with the growth of cilia, one of the first morphogenetic events during development. The product of this gene was characterized using an antiserum raised against a peptide corresponding to the predicted amino-terminal portion of the protein. This thesis describes the localization of the Spec3 protein at different stages during embryonic development. Immunocytochemistry indicated that the protein is associated with cilia and Golgi complexes of ectodermal cells. Agents that inhibit protein synthesis and Go

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14

Al-Ameeri, A.-A. "Protein intake, ammonia excretion and growth of Oreochromis spilurus in sea water." Thesis, University of Stirling, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233795.

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15

SAILE, RACHID. "L'apolipoproteine serique amyloide a : methodologie de dosage utilisant des peptides synthetiques, applications cliniques." Lille 2, 1989. http://www.theses.fr/1989LIL2P252.

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16

Pines, J. N. J. "Cyclin : a major maternal message in sea urchin eggs." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233321.

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In this thesis I describe the construction of a cDNA library of maternal mRNA from the sea-urchin <i>Arbacia punctulata</i> and the subsequent isolation of a cDNA clone for the cylin protein using the technique of hybrid-arrest of translation. The cyclin protein was originally identified in sea-urchin embryos as a protein that was strongly synthesised after fertilisation but destroyed at each cell division (Evans <i>et al</i>, 1983). The DNA sequence of the putative cyclin clone was determined. It contains an open reading frame for a protein of M<SUB>r</SUB>46,000 which bears significant homol

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17

Burns, Joseph. "Development of a Protein-Based Therapy for the Treatment of Spinal Muscular Atrophy." Thèse, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/30697.

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The autosomal recessive disorder spinal muscular atrophy (SMA) causes motor neuron degeneration and muscle wasting, progressing to paralysis and death in severe cases. The disease is caused by deficiency of survival motor neuron protein (SMN) due to deletion or mutation of the SMN1 gene. We seek to develop a protein-based therapy for SMA using an adenoviral vector which encodes a secretable form of SMN fused to a protein transduction domain (PTD) derived from the trans-acting activator of transcription (TAT) from HIV. We generated secretable GFP proteins using transient transfection in mammali

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18

Tognoloni, Cecilia. "Formation of polymer lipid nanodiscs for membrane protein studies." Thesis, University of Bath, 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.760950.

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19

KATT, ABDELAZIZ. "Interets des tests inflammatoires pratiques sur le serum en rhumatologie." Strasbourg 1, 1991. http://www.theses.fr/1991STR15072.

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20

Garcia, Paulo Ricardo de Abreu Furtado. "Síntese e análise da sílica mesoporosa SBA-15 para incorporação de moléculas." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/43/43134/tde-27042015-084615/.

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Neste trabalho estudou-se a encapsulação de proteínas com diferentes pesos moleculares na sílica mesoporosa ordenada SBA-15 para avaliar sua aplicação como adjuvante imunológico. Para tanto, as proteínas IgG (150 kDa) e BSA (66,5 kDa) foram incorporadas à sílica mesoporosa com poros expandidos. Primeiramente estudou-se a dilatação dos poros utilizando-se um agente dilatador de estrutura no processo de síntese, através da preparação de amostras com diferentes quantidades de triisopropilbenzeno (TIPB). Resultados de isoterma de adsorção de nitrogênio (NAI) e espalhamento de raios X a baixo ângul

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21

Ko, Kochun. "Bactericidal Mechanisms of Escapin, A Protein in the Ink of a Sea Hare." Digital Archive @ GSU, 2011. http://digitalarchive.gsu.edu/biology_diss/92.

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@font-face { font-family: "Arial"; }@font-face { font-family: "ＭＳ明朝"; }@font-face { font-family: "Calibri"; }p.MsoNormal, li.MsoNormal, div.MsoNormal { margin: 0in 0in 0.0001pt; text-indent: 0.5in; line-height: 200%; font-size: 11pt; font-family: "Times New Roman"; }p.MsoBodyText, li.MsoBodyText, div.MsoBodyText { margin: 0in 0in 6pt; text-indent: 0.5in; line-height: 200%; font-size: 11pt; font-family: "Times New Roman"; }span.BodyTextChar { font-family: Calibri; }div.Section1 { page: Section1; } A 60 kDa monomeric protein isolated from the defensive purple ink secretion of the sea hare

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22

Balmant, Kelly Mayrink. "Identificação de um fator do hospedeiro, RPS5A, envolvido na interação com a proteína de movimento (MP) de geminivírus." Universidade Federal de Viçosa, 2011. http://locus.ufv.br/handle/123456789/4743.

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Made available in DSpace on 2015-03-26T13:42:20Z (GMT). No. of bitstreams: 1 texto completo.pdf: 2368630 bytes, checksum: cd9eaf09470bcfbf6727027ecade3b46 (MD5) Previous issue date: 2011-02-18<br>Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>The movement protein MP from bipartite geminivirus (begomovirus) facilitates the cell-to-cell and long-distance transport of viral DNA in addition to affecting viral pathogenicity. To identify host factors that interact with MP, initially a cDNA library prepared from CaLCuV (Cabbage leaf curl virus)-infected Arabidopsis leaf mRNA was g

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23

Eriksson, Hägg Hanna. "Nitrogen land-sea fluxes in the Baltic Sea catchment : Empirical relationships and budgets." Doctoral thesis, Stockholms universitet, Institutionen för tillämpad miljövetenskap (ITM), 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-32493.

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In this thesis empirical relationships and modeling tools are used to describe the relationship between human activities and meso- and large scale riverine N fluxes from land to sea. On a large scale Paper I showed that by only having knowledge about human population size and runoff one can estimate the riverine export of DIN (r2= 0.76). In Paper II we included two other important anthropogenic N inputs, i.e. atmospheric deposition and primary emission (PE) from animals. In most of the catchments the PE from animals were larger than the PE from humans. Hence, development of livestock is import

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24

Elardo, Karen Marie. "Changes in Proteins Associated with Nitrogen Fixation and Iron Nutrition in the Marine Cyanobacterium Trichodesmium." PDXScholar, 1994. https://pdxscholar.library.pdx.edu/open_access_etds/4902.

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This investigation tested the hypothesis that iron, as a micronutrient, will affect proteins in Trichodesmium and therefore affect nitrogen fixation. Changes in proteins that are a result of iron enrichment were compared to naturally occuring diel changes. Alterations in the iron protein of nitrogenase were compared to nitrogen fixation rates using the acetylene reduction technique. The observed changes in proteins were compared in Trichodesmium colonies from the Caribbean Sea and the Sargasso Sea. Trichodesmium colonies were monitored for protein and iron content over a diel period on two cru

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25

Churamani, Dev. "Properties of the nicotinic acid adenine dinucleotide phosphate-binding protein in sea urchin eggs." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1444577/.

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Nicotinic acid adenine dinucleotide phosphate (NAADP) has recently emerged as a novel intracellular calcium mobilising messenger in a variety of cells. Whilst increasing evidence suggests that NAADP acts on a distinct binding protein, little is known regarding the biochemical properties of the putative NAADP "receptor". My thesis investigates properties of the NAADP-binding protein in sea urchin eggs. Firstly, I show that NAADP binding to its target protein is inhibited by altering the protein:lipid ratio of soluble sea urchin egg homogenates - an effect prevented and reversed specifically by

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26

Scherer, Sonja Daniela. "Protein purification and cDNA cloning of suGF1 : a sea urchin nuclear DNA-binding factor." Doctoral thesis, University of Cape Town, 1998. http://hdl.handle.net/11427/21905.

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The upstream regulatory regions of numerous genes contain contiguous deoxyguanosine residues (G·C-rich sequences) which have been implicated in the regulation of gene expression, since they may involve alterations in their DNA structure, the binding of G-string factors and in some cases even the displacement of a nucleosome positioned over this area. A poly( dG).poly( de)-binding protein (suGF1) has previously been identified and purified on a small scale from embryonic nuclear extracts of the sea urchin Parechinus angulosus (1, 2). suGF1 binds in vitro to the H1-H4 intergenic region of the ea

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27

Lee, Charles Kai-Wu. "Eurythermalism of a deep-sea symbiosis system from an enzymological aspect." The University of Waikato, 2007. http://hdl.handle.net/10289/2588.

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The recently proposed and experimentally validated Equilibrium Model provides the most detailed description of temperature's effect on enzyme catalytic activity to date. By introducing an equilibrium between Eact, the active form of enzyme, and Einact, a reversibly inactivated form of enzyme, the Equilibrium Model explains apparent enzyme activity loss at high temperatures that cannot be accounted for by irreversible thermal denaturation. The Equilibrium Model describes enzyme behavior in the presence of substrates and under assay conditions; thus its associated parameters, deltaHeq and Teq,

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28

Domènech, Guitart Anna. "Analysis of the functional roles of Mammary Serum Amyloid A3 protein." Doctoral thesis, Universitat Autònoma de Barcelona, 2013. http://hdl.handle.net/10803/125923.

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La Serum Amiloide A3 (M‐SAA3) mamària és una proteïna de fase aguda expressada principalment a la glàndula mamària. Els nivells d’expressió de la M‐SAA3 varia en diferents situacions fisiològiques, el que suggereix un rol important a nivell funcional. Per tal d’analitzar les propietats de la proteïna, es van dur a terme quatre estudis. En el primer, la M‐SAA3 va ser expressada de forma recombinant en un sistema bacterià. Aquest pas és important ja que ens proporciona una font de proteïna, en casos en que la purificació de fonts naturals representa clarament un coll d’ampolla. Es va obten

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29

Maripuu, Linda. "Superantigens in group A streptococcus : gene diversity and humoral immune response." Doctoral thesis, Umeå universitet, Biomedicinsk laboratorievetenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-46454.

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Group A streptococcus (GAS) is a strictly human pathogen that causes infections ranging from asymptomatic carriage to the highly lethal streptococcal toxic shock syndrome (STSS). GAS are classified according to the sequence of the variable 5’ end of the emm-gene that encodes the surface associated M-protein. In the late 1980s, outbreaks of GAS infections with high rates of STSS were reported in several parts of the world, including Sweden. Superantigens (SAgs), a group of exotoxins, have been described as key mediators of STSS due to their capacity to polyclonally activate T-cells and induce a

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30

Alban, Andrew. "The interactions of ubiquiton-containing proteins with S5a and the 26S proteasome." Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323187.

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31

Brodaczewska, Natalia Anna. "NMR and in silico studies of fucosylated chondroitin sulfate (fCS) and its interactions with selectins." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31232.

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This thesis describes structural studies on the interactions between the fucosylated chondroitin sulfate (fCS) oligosaccharides and human proteins known as selectins. fCS is a carbohydrate obtained from sea cucumbers, that can be classified as a branched glycosaminoglycan (GAG). It has attracted much attention due to its anti-coagulant, anti-inflammatory, antimetastatic and anti-HIV properties and its structure was previously determined by NMR. Selectins constitute a family of proteins involved in cell adhesion processes, such as inflammation, attachment of viral particles and migration of tum

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32

KATIYAR, AMIT. "Development of Novel Mesoporous Silicates for Bioseparations and Biocatalysis." University of Cincinnati / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1204765205.

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33

Cameron, Bruce Andrew. "Unique distribution of the anion exchange protein in the ancient vertebrate, the sea lamprey, Petromyzon marinus." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ42939.pdf.

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34

Martin, Jose Manuel Vergara. "Studies on the utilization of dietary protein and energy by gilthead sea bream (Sparus aurata L.)." Thesis, University of Stirling, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317614.

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35

Rezek, Troy. "The effects of dietary Docosahexaenocic acid (22:6n-3) and Arachidonic acid (20:4n-6) on growth, survival and stress resistance in black sea bass (Centropristis striata) larvae /." Electronic version (PDF), 2005. http://dl.uncw.edu/etd/2005/rezekt/troyrezek.pdf.

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36

Oliveira, Edson Mendes de. "Amilóide sérica A (SAA): produção da proteína recombinante humana SAA1 e SAA4 e sua expressão nativa em células do tecido adiposo submetidas à hipóxia." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-20052013-165307/.

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Visando novos estudos com a proteína amilóide sérica A (SAA), propusemos a produção de seu recombinante humano em Escherichia coli, mais especificamente, a isoforma encontrada na fase aguda (A-SAA1) e da constitutivamente expressa (C-SAA4). Realizamos a expressão, identificação e purificação das proteínas recombinantes. Concomitantemente, também avaliamos o efeito da hipóxia na expressão e produção da proteína SAA nativa em linhagens de pré-adipócitos murinos 3T3-L1, não diferenciados e diferenciados e adipócitos humanos. Aparentemente quanto maior o grau de diferenciação celular, maior a expr

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37

Mah, Silvia Armitano. "Molecular analysis of sea urchin sperm receptor proteins containing receptor for egg jelly (REJ) modules /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2004. http://wwwlib.umi.com/cr/ucsd/fullcit?p3137207.

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38

Catanzaro, Nicholas Jr. "Molecular Mechanisms of Host Responses to Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Infection." Diss., Virginia Tech, 2020. http://hdl.handle.net/10919/97907.

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Porcine reproductive and respiratory syndrome virus (PRRSV) is arguably the most economically devastating pathogen affecting the global swine industry. Since the emergence of the virus in the late 1980s, vaccination strategies aimed to control the virus have not been very effective. Current commercial vaccines are generally protective against homologous or closely-related strains but ineffective at conferring heterologous protection against genetically-diverse strains of the virus. Consequently, emergence of variant and sometime more pathogenic strains of PRRSV continues in global swine herds.

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39

Alford, Lea Marie. "Identification and Spatiotemporal Control of the Asymmetrical Membrane Cortex in Cleavage Stage Sea Urchin Embryos." Thesis, Boston College, 2009. http://hdl.handle.net/2345/978.

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Thesis advisor: David R. Burgess<br>Polarity established by the first cleavages in sea urchin embryos was investigated in this thesis revealing precocious embryonic polarity. Studies of embryonic polarity have focused on protostomes such as C. elegans, and those on deuterostomes have focused on later developmental stages. I find asymmetries in the sea urchin membrane cell cortex as early as the first division after fertilization as a result of new membrane addition in the cleavage furrow. Membrane domains and the polarity determinants Par6, aPKC, and Cdc42 are polarized to the apical, or free,

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40

Arumugam, Saravanan. "A Study on the Role of NF-kB Signaling Pathway Members in Regulating Survival Motor Neuron Protein level and in the Pathogenesis of Spinal Muscular Atrophy." Doctoral thesis, Universitat de Lleida, 2017. http://hdl.handle.net/10803/400607.

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L’atròfia muscular espinal (AME) és una malaltia neuromuscular causada per mutació o deleció en el gen SMN1, que codifica per la proteïna ubiqua SMN (de l’anglès survival motor neuron). L’AME es caracteritza per atròfia muscular i degeneració de les motoneurones (MN) de la medul·la espinal. Els esdeveniments moleculars que causen la vulnerabilitat específica de les MN amb nivells baixos de proteïna SMN encara no es coneixen. La via de l’NF-κB (nuclear factor-κB) ha destacat recentment ja que sembla jugar un paper cabdal en la supervivència de les MN i en les malalties neurodegeneratives. Els f

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41

Scaramuzzi, Karina. "Investigação dos mecanismos de ação da sílica mesoporosa nanoestruturada SBA-15 como adjuvante." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-07062014-111900/.

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Sílicas mesoporosas, como a SBA-15, constituem-se de partículas de óxido de silício que, devido às suas propriedades físico-químicas apresentam potencial adjuvante. Para entender os mecanismos de ação da SBA-15, camundongos foram imunizados, pelas vias oral e/ou subcutânea (s.c.), com a proteína recombinante HBsAg ou ovalbumina (OVA) e apresentaram aumento significativo nos títulos de anticorpos específicos após imunização s.c. com ambos os antígenos em sílica; entretanto, somente a administração de HBsAg: SBA-15 induziu a produção de anticorpos pela via oral. O efeito da sílica na ativação de

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42

Faleiro, Michelle R. 1987. "Delineating a requirement for Survival of Motor Neuron (SMN) protein in skeletal muscle tissue." Doctoral thesis, Universitat Pompeu Fabra, 2017. http://hdl.handle.net/10803/664120.

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Spinal Muscular Atrophy (SMA) is an autosomal recessive neuromuscular disorder characterized by the degeneration of the lower motor neurons. It is caused by homozygous loss or mutations in the Survival Motor Neuron 1 (SMN1) gene, leading to a reduction of the amount of Survival Motor Neuron (SMN) protein. In human patients, an almost identical copy gene, SMN2, is unable to fully compensate for the lack of SMN1, due to a C to T transition in exon 7. Despite progress in the field, the cellular site of action of the SMN protein remains incomplete. Fully defining it is critical for clinical treatm

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Hoffman, Matthew P. "The Cortical response to RhoA is regulated during mitosis. Annotation of cytoskeletal and motility proteins in the sea urchin genome assembly." Thesis, Boston College, 2008. http://hdl.handle.net/2345/bc-ir:107671.

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Thesis advisor: David Burgess<br>This doctoral thesis addresses two central topics divided into separate chapters. In Chapter 1: The cortical response to RhoA is regulated during mitosis, experimental findings using sea urchin embryos are presented that demonstrate that the small GTPase RhoA participates in positive signaling for cell division and that this activity is negatively regulated prior to anaphase. In a second series of experiments, myosin phosphatase is shown to be a central negative regulator of myosin activity during the cell cycle through metaphase of mitosis and experimental fin

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Scucchia, Federica. "Transcriptional profiles inferring thermal stress responses of the coral Oculina patagonica from the Eastern Mediterranean Sea." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/17967/.

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During the past several decades, corals worldwide have been dealing with a considerable increase in water temperature due to climate change, which is predicted to increase the frequency of coral bleaching and mass mortality events. Nevertheless, corals show differences in stress susceptibility and they are not all affected evenly. The symbiotic coral Oculina patagonica from the Eastern Mediterranean Sea can thrive in relatively unstable environments and is considered a stress-tolerant species. In this study, baseline expression and temporal dynamics of induction of a 70-kDa heat shock protein

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Bayer, Maddalena [Verfasser], Gerhard [Akademischer Betreuer] Dieckmann, Ulrich [Akademischer Betreuer] Bathmann, and Allan [Akademischer Betreuer] Cembella. "Antifreeze Proteins from the Sea Ice Diatom Fragilariopsis cylindrus / Maddalena Bayer. Gutachter: Ulrich Bathmann ; Allan Cembella. Betreuer: Gerhard Dieckmann." Bremen : Staats- und Universitätsbibliothek Bremen, 2011. http://d-nb.info/1071898264/34.

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Sha, Xiaojin [Verfasser], Achim [Gutachter] Leutz, Harald [Gutachter] Saumweber, and Wolfgang [Gutachter] Uckert. "Translation initiation factor 4E binding protein 1,2 (4E-BP1,2) in hematopoiesis and stress erythropoiesis / Xiaojin Sha ; Gutachter: Achim Leutz, Harald Saumweber, Wolfgang Uckert." Berlin : Humboldt-Universität zu Berlin, 2008. http://d-nb.info/1208077198/34.

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Hultén, Cecilia. "Serum amyloid A (SAA) as a marker of inflammation in the horse : biochemical, experimental and clinical studies /." Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 1999. http://epsilon.slu.se/avh/1999/91-576-5449-2.pdf.

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Estruch, Cucarella Guillem. "ASSESSMENT OF THE LONG-TERM IMPACT OF HIGH PLANT PROTEIN DIETS ON THE INTESTINAL STATUS OF THE ON-GROWING GILTHEAD SEA BREAM (Sparus aurata, L.)." Doctoral thesis, Universitat Politècnica de València, 2018. http://hdl.handle.net/10251/113063.

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Aunque el uso de altos niveles de fuentes de proteína vegetal en piensos para doradas de engorde se ha alcanzado con éxito en cuanto al crecimiento, estas dietas todavía están asociadas a efectos negativos en la eficiencia nutricional y en la capacidad inmunitaria. El intestino es el órgano donde se produce la primera interacción entre el pez, los nutrientes y las bacterias del medio, y desarrolla un papel crucial en la digestión de los nutrientes y la respuesta infamatoria e inmune. Esta tesis doctoral se centra en el impacto de distintas dietas con altos niveles de proteína vegetal, y especi

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Hameed, Shaista. "Investigation of the production and isolation of bioactive compounds from cyanobacteria." Thesis, Robert Gordon University, 2013. http://hdl.handle.net/10059/841.

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Due to heavy nutrient load and adverse climate change the occurrence of toxic cyanobacterial blooms have significantly increased during the last decades. Nodularia spumigena is one of the dominant toxic cyanobacteria which produces massive and inherent blooms in brackish water body, the Baltic Sea, particularly in late summer. Nodularia spp. are known to produce nodularins (NOD) and a range of other bioactive peptides such as spumigins and nodulopeptins, all of which have unclear function. In a recent study, three new nodulopeptins with molecular weight of 899, 901 and 917 were characterised f

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Edblom, Sara. "A Comparison of Two Immunoturbidimetric Assay Methods for Serum Amyloid A in Cats." Thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-154803.

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The analysis of acute phase protein serum amyloid A (SAA) has recently been brought into clinical use in veterinary medicine. Some of the difficulties with incorporating the SAA method in clinical practice have been the expensive and rather large equipment required for the method. Due to these difficulties only larger clinics can afford to use the SAA analysis. The company Equinostic has recently developed a smaller instrument that costs one-tenth of a larger instrument. The instrument is named EVA1 and has so far only been used to analyze SAA in horses. The aim of this study was to investigat

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