Acceder

Bibliografías temáticas / Skeletal muscle / Tesis

Siga este enlace para ver otros tipos de publicaciones sobre el tema: Skeletal muscle.

Tesis sobre el tema "Skeletal muscle"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 25 de julio de 2025

Crea una cita precisa en los estilos APA, MLA, Chicago, Harvard y otros

Elija tipo de fuente:

Consulte los 50 mejores tesis para su investigación sobre el tema "Skeletal muscle".

Junto a cada fuente en la lista de referencias hay un botón "Agregar a la bibliografía". Pulsa este botón, y generaremos automáticamente la referencia bibliográfica para la obra elegida en el estilo de cita que necesites: APA, MLA, Harvard, Vancouver, Chicago, etc.

También puede descargar el texto completo de la publicación académica en formato pdf y leer en línea su resumen siempre que esté disponible en los metadatos.

Explore tesis sobre una amplia variedad de disciplinas y organice su bibliografía correctamente.

1

Foxton, Ruth. "Dysferlin in skeletal muscle and skeletal muscle disease." Thesis, University of Newcastle Upon Tyne, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268429.

Texto completo

Los estilos APA, Harvard, Vancouver, ISO, etc.

2

Pathare, Neeti C. "Metabolic adaptations following disuse and their impact on skeletal muscle function." [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0010024.

Texto completo

Resumen

Thesis (Ph.D.)--University of Florida, 2005.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 171 pages. Includes Vita. Includes bibliographical references.

Los estilos APA, Harvard, Vancouver, ISO, etc.

3

Peoples, Gregory Edward. "Skeletal muscle fatigue can omega-3 fatty acids optimise skeletal muscle function? /." Access electronically, 2004. http://www.library.uow.edu.au/adt-NWU/public/adt-NWU20041217.123607.

Texto completo

Resumen

Thesis (Ph.D.)--University of Wollongong, 2004.<br>Typescript. This thesis is subject to a 12 month embargo (06/09/05 - 14/09/05) and may only be viewed and copied with the permission of the author. For further information please contact the Archivist. Includes bibliographical references: leaf 195-216.

Los estilos APA, Harvard, Vancouver, ISO, etc.

4

Salman, Mahmoud M. "Preconditioning in skeletal muscle." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1446109/.

Texto completo

Resumen

Ischaemia reperfusion injury of skeletal muscle is a major cause of morbidity and mortality in various surgical specialities. Developing a protective method or pharmacological agent that will limit this damage will be of considerable benefit to both patients and doctors. I have used potassium channel openers and calcium as preconditioning agents. The results show that potassium channel openers are a viable option whereas the use of calcium can exacerbate muscle damage. I looked at various protocols of ischaemic and pharmacological preconditioning. The results from both ischaemic and pharmacolo

Los estilos APA, Harvard, Vancouver, ISO, etc.

5

Blackwell, Danielle. "The role of Talpid3 in skeletal muscle satellite cells and skeletal muscle regeneration." Thesis, University of East Anglia, 2017. https://ueaeprints.uea.ac.uk/66948/.

Texto completo

Resumen

The primary cilium has recently been recognised as an essential regulator of the Sonic hedgehog (Shh) signalling pathway. Mutations that disrupt cilia function in humans can cause conditions known as ciliopathies. A wide range of phenotypes is observed in chick and mouse ciliopathy models,including polydactyly, craniofacial defects and polycystic kidneys. The Shh pathway and therefore primary cilia are vital for many developmental processes, including embryonic muscle development, with recent evidence suggesting they may also play a role in adult muscle regeneration. Our studies focus on the T

Los estilos APA, Harvard, Vancouver, ISO, etc.

6

Baker, Brent A. "Characterization of skeletal muscle performance and morphology following acute and chronic mechanical loading paradigms." Morgantown, W. Va. : [West Virginia University Libraries], 2007. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5325.

Texto completo

Resumen

Thesis (Ph. D.)--West Virginia University, 2007.<br>Title from document title page. Document formatted into pages; contains xii, 270 p. : ill. (some col.). Includes abstract. Includes bibliographical references.

Los estilos APA, Harvard, Vancouver, ISO, etc.

7

Zhang, Yan. "Cytokines and skeletal muscle wasting." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/MQ47124.pdf.

Texto completo

Los estilos APA, Harvard, Vancouver, ISO, etc.

8

Oude, Vrielink Hubertus Hermanus Egbert. "Vasomotion and skeletal muscle perfusion." Maastricht : Maastricht : Rijksuniversiteit Limburg ; University Library, Maastricht University [Host], 1988. http://arno.unimaas.nl/show.cgi?fid=5409.

Texto completo

Los estilos APA, Harvard, Vancouver, ISO, etc.

9

Walsh, Garrett Lyndon. "Skeletal muscle powered cardiac assist." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=63879.

Texto completo

Los estilos APA, Harvard, Vancouver, ISO, etc.

10

Kochamba, Gary. "Skeletal muscle powered cardiac assist." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61746.

Texto completo

Los estilos APA, Harvard, Vancouver, ISO, etc.

11

Mofarrahi, Mahroo. "Angiopoietins and skeletal muscle function." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=106387.

Texto completo

Resumen

Angiopoietins are ligands for the endothelial cell-specific Tie-2 receptors. Angiopoietin-1 (Ang-1) activates Tie-2 receptors in the vasculature and promotes endothelial cell survival, proliferation, migration and differentiation. Angipoietin-2 (Ang-2) is synthesized mainly by endothelial cells and antagonizes Ang-1-induced Tie-2 receptor activation. In special circumstances, Ang-2 activates Tie-2 receptors and promotes angiogenesis. In this thesis, I address the regulation and functional significance of angiopoietins and Tie-2 receptors in normal and regenerating skeletal muscles. I describe

Los estilos APA, Harvard, Vancouver, ISO, etc.

12

Sanderson, Alison Louise. "Regulation of skeletal muscle metabolism." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318615.

Texto completo

Los estilos APA, Harvard, Vancouver, ISO, etc.

13

Wang, Zai, and 王在. "Kinesin-1 in skeletal muscle." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41757877.

Texto completo

Los estilos APA, Harvard, Vancouver, ISO, etc.

14

Slee, Adrian. "Regulation of skeletal muscle proteolysis." Thesis, University of Nottingham, 2005. http://eprints.nottingham.ac.uk/13105/.

Texto completo

Resumen

Proteolysis is a component of protein turnover, controlled by multiple proteolytic systems. Alterations in system components within skeletal muscle has been associated with hypertrophy, remodelling, atrophy, apoptosis and metabolic dysregulation. Key components may have novel regulatory roles, e. g. calpain-3 and cathepsin-L. Experiments described within this thesis investigated the hypothesis that the gene expression of specific proteolytic system components within skeletal muscle may be co-ordinately regulated and altered during nutritional and pharmacological states known to modify protein

Los estilos APA, Harvard, Vancouver, ISO, etc.

15

Spencer, C. I. "Chemomechanical coupling in skeletal muscle." Thesis, Open University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383710.

Texto completo

Los estilos APA, Harvard, Vancouver, ISO, etc.

16

Jones, Garrett Collier. "Skeletal Muscle Recovery and Vibration." BYU ScholarsArchive, 2019. https://scholarsarchive.byu.edu/etd/8285.

Texto completo

Resumen

In the past decade there has been a significant increase in focus on the effect upper body vibration (UBV) has on the recovery of skeletal muscle after exercise-induced muscle damage. Recovery can be defined and investigated using a wide variety of methods. This study used three different measurements to track muscle recovery over 7 days following an exercise muscle damage protocol and applied vibration to a mathematical model. A visual analog scale (VAS) was used to measure muscle pain, a strain gauge was used to obtain maximum voluntary isometric contraction (MVIC) strength measurements, and

Los estilos APA, Harvard, Vancouver, ISO, etc.

17

Shue, Guay-Haur. "System models of skeletal muscle." Case Western Reserve University School of Graduate Studies / OhioLINK, 1995. http://rave.ohiolink.edu/etdc/view?acc_num=case1058448071.

Texto completo

Los estilos APA, Harvard, Vancouver, ISO, etc.

18

Wang, Zai. "Kinesin-1 in skeletal muscle." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41757877.

Texto completo

Los estilos APA, Harvard, Vancouver, ISO, etc.

19

Stone, Michael H. "Mechanisms of Skeletal Muscle Hypertrophy." Digital Commons @ East Tennessee State University, 2010. https://dc.etsu.edu/etsu-works/4532.

Texto completo

Los estilos APA, Harvard, Vancouver, ISO, etc.

20

Stone, Michael H. "Mechanisms of Skeletal Muscle Hypertrophy." Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etsu-works/4544.

Texto completo

Los estilos APA, Harvard, Vancouver, ISO, etc.

21

Stone, Michael H. "Development of Skeletal Muscle Hypertrophy." Digital Commons @ East Tennessee State University, 2010. https://dc.etsu.edu/etsu-works/4579.

Texto completo

Los estilos APA, Harvard, Vancouver, ISO, etc.

22

Ram, Umilla Bettina. "Role of ICL2 in skeletal muscle regeneration." Electronic Thesis or Diss., Université de Lille (2022-....), 2024. https://pepite-depot.univ-lille.fr/ToutIDP/EDBSL/2024/2024ULILS058.pdf.

Texto completo

Resumen

Le muscle squelettique possède une importante capacité de régénération en réponse aux dommages causés par des blessures, des exercices intensifs ou des myopathies, grâce aux cellules souches musculaires (MuSCs) situées sous la lame basale des fibres en état de quiescence au repos. Suite à une lésion, ces cellules s'activent, prolifèrent et se différencient en myoblastes, lesquels fusionnent pour former de nouveaux myotubes. La régénération musculaire implique également un recrutement de cellules immunitaires qui sont essentielles à l'élimination des débris nécrotiques et au retour à l'homéosta

Los estilos APA, Harvard, Vancouver, ISO, etc.

23

Dunaway, Dwayne Lee. "Nano-mechanics of skeletal muscle structures /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/8022.

Texto completo

Los estilos APA, Harvard, Vancouver, ISO, etc.

24

Scionti, Isabella. "Epigenetic Regulation of Skeletal Muscle Differentiation." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSEN084/document.

Texto completo

Resumen

LSD1 et PHF2 sont des déméthylases de lysines capables de déméthyler à la fois les protéines histones qui influencent l’expression génique et les protéines non histones en affectant leurs activités ou stabilités. Des approches fonctionnelles d’inactivation de Lsd1 ou Phf2 chez la souris ont démontré l’implication de ces enzymes dans l'engagement des cellules progénitrices au cours de la différenciation. La myogenèse est l'un des exemples les mieux caractérisés sur la façon dont les cellules progénitrices se multiplient et se différencient pour former un organe fonctionnel. Elle est initiée par

Los estilos APA, Harvard, Vancouver, ISO, etc.

25

Yeung, Wai Ella, and 楊慧. "Eccentric contraction-induced injury in mammalian skeletal muscle." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B29750313.

Texto completo

Los estilos APA, Harvard, Vancouver, ISO, etc.

26

Pillitteri, Paul J. "Regeneration of Rat Skeletal Muscle Following a Muscle Biopsy." Ohio University / OhioLINK, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1118087917.

Texto completo

Los estilos APA, Harvard, Vancouver, ISO, etc.

27

Arc-Chagnaud, Coralie. "Regulation of antioxidant defenses in the prevention of skeletal muscle deconditioning." Thesis, Montpellier, 2019. http://www.theses.fr/2019MONT4005.

Texto completo

Resumen

Le système musculaire joue un rôle primordial dans l’homéostasie de l’organisme. Il est impliqué dans différentes fonctions indispensables aux activités de la vie quotidienne telles que la production de mouvement, la locomotion, le maintien postural et l’équilibre. La qualité du tissu musculaire est donc primordiale dans le maintien de la qualité de vie et, à long terme, à la longévité. L'hypoactivité et le vieillissement sont deux situations qui entraînent le déconditionnement musculaire, et qui partagent une caractéristique commune: une perte de force musculaire, une atrophie et la modificat

Los estilos APA, Harvard, Vancouver, ISO, etc.

28

Wood, Stephanie Ann Cardinal Trevor R. "A morphological and hemodynamic analysis of skeletal muscle vasculature : a thesis /." [San Luis Obispo, Calif. : California Polytechnic State University], 2008. http://digitalcommons.calpoly.edu/theses/16/.

Texto completo

Resumen

Thesis (M.S.)--California Polytechnic State University, 2008.<br>"July 2008." "In partial fulfillment of the requirements for the degree [of] Master of Science in Engineering with a specialization in Biomedical Engineering." "Presented to the faculty of California Polytechnic State University, San Luis Obispo." Major professor: Trevor Cardinal, Ph.D. Includes bibliographical references (leaves 96-101). Also available on microfiche and online.

Los estilos APA, Harvard, Vancouver, ISO, etc.

29

Aydin, Jan. "Skeletal muscle calcium homeostasis during fatigue : modulation by kinases and mitochondria /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-247-7/.

Texto completo

Los estilos APA, Harvard, Vancouver, ISO, etc.

30

Vlahovich, Nicole. "The role of cytoskeletal tropomyosins in skeletal muscle and muscle disease." Thesis, View thesis, 2007. http://handle.uws.edu.au:8081/1959.7/32176.

Texto completo

Resumen

Cells contain an elaborate cytoskeleton which plays a major role in a variety of cellular functions including: maintenance of cell shape and dimension, providing mechanical strength, cell motility, cytokinesis during mitosis and meiosis and intracellular transport. The cell cytoskeleton is made up of three types of protein filaments: the microtubules, the intermediate filaments and the actin cytoskeleton. These components interact with each other to allow the cell to function correctly. When functioning incorrectly, disruptions to many cellular pathway have been observed with mutations in vari

Los estilos APA, Harvard, Vancouver, ISO, etc.

31

Maenhout, Mascha. "Strain fields within contracting skeletal muscle." Eindhoven : Maastricht : Technische Universiteit Eindhoven ; University Library, Maastricht University [Host], 2002. http://arno.unimaas.nl/show.cgi?fid=7018.

Texto completo

Los estilos APA, Harvard, Vancouver, ISO, etc.

32

Geukes, Foppen Remco Jan. "Electrical bistability of skeletal muscle membrane." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2005. http://dare.uva.nl/document/78574.

Texto completo

Los estilos APA, Harvard, Vancouver, ISO, etc.

33

Raue, Ulrika. "Skeletal muscle gene expression with age." Virtual Press, 2007. http://liblink.bsu.edu/uhtbin/catkey/1370882.

Texto completo

Resumen

The aim of this research was to investigate myogenic (i.e. growth) and proteolytic (i.e. breakdown) gene expression (GE) in skeletal muscle of young and old women. Myogenic (MyoD, MRF4, Myf5, myogenin, myostatin) and proteolytic (Atrogin-1, MuRF-1, FOXO3A) genes were examined in the basal state and after resistance exercise (RE). Six old women (OW: 85 ± 1 y) and eight young women (YW: 23 ± 1) performed 3 x 10 knee extensions at 70% of 1-repetition-maximum. Muscle biopsies were obtained from the vastus lateralis (i.e. thigh) before and 4 hours after RE.In the basal state, OW expressed higher le

Los estilos APA, Harvard, Vancouver, ISO, etc.

34

Tallon, Mark J. "Carnosine metabolism in human skeletal muscle." Thesis, University of Chichester, 2005. http://eprints.chi.ac.uk/843/.

Texto completo

Los estilos APA, Harvard, Vancouver, ISO, etc.

35

Kwende, Martin M. N. "The biomechanics of skeletal muscle ventricles." Thesis, University of Liverpool, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283451.

Texto completo

Los estilos APA, Harvard, Vancouver, ISO, etc.

36

Levy, Louis Bernard. "Nutrition, infection and skeletal muscle function." Thesis, University of Southampton, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316459.

Texto completo

Los estilos APA, Harvard, Vancouver, ISO, etc.

37

Campbell, Robert N. "Glucose-regulated transcription in skeletal muscle." Thesis, University of Newcastle Upon Tyne, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427295.

Texto completo

Los estilos APA, Harvard, Vancouver, ISO, etc.

38

Alam, Nasreen. "Malonyl-coa metabolism in skeletal muscle." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300485.

Texto completo

Los estilos APA, Harvard, Vancouver, ISO, etc.

39

Smith, N. "Thiol signalling in skeletal muscle ageing." Thesis, University of Liverpool, 2018. http://livrepository.liverpool.ac.uk/3026986/.

Texto completo

Resumen

An age-related loss of muscle mass is associated with increased frailty in the elderly. The effect is felt at both a national scale, with an increased budgetary demand for health services directed towards the ageing population, and by the individual where reduced mobility significantly reduces their quality of life. It is unclear whether all skeletal muscle types are affected in the same manner. This thesis considered how thiol signalling, facilitated through reactive thiol groups on cysteine amino acids, may affect skeletal muscle ageing as it is crucial for normal intracellular function. Sev

Los estilos APA, Harvard, Vancouver, ISO, etc.

40

Stickland, Neil Charles. "Development and growth of skeletal muscle." Thesis, University of Edinburgh, 1998. http://hdl.handle.net/1842/30012.

Texto completo

Resumen

The main body of this work contributes to an understanding of the development and growth of skeletal muscle in a range of Vertebrates from fish to pigs. Particular emphasis is paid to the contribution of numbers and types of muscle fibres to overall muscle growth and ultimate mass, and also to the mechanisms whereby factors such as nutrition in mammals and temperature in fish may affect these parameters. The work is divided into three main sections. The first section covers aspects of prenatal mammalian development including myogenesis and placentation. Muscle develops as two populations of mu

Los estilos APA, Harvard, Vancouver, ISO, etc.

41

Nikoi, Naa-Dei. "Cellulose nanowhiskers for skeletal muscle engineering." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/cellulose-nanowhiskers-for-skeletal-muscle-engineering(30db0446-d55b-40aa-b759-c8e2c71a4cf6).html.

Texto completo

Resumen

Prior work has shown that spin-coating tunicin cellulose nanowhiskers onto a glass surface creates a highly oriented surface that supports the adhesion, spreading and proliferation of myotubes. Building on this work, this project aimed to develop culture surfaces with biologically active topography and tuneable stiffness with the aim of better mimicking native muscle tissue. The ultimate aim is to develop biomaterials that can direct the differentiation of mesenchymal stem cells. Cellulose nanocrystals (CNWs) from Ascidiella spp were isolated and characterised. Polyelectrolyte multilayers (PEM

Los estilos APA, Harvard, Vancouver, ISO, etc.

42

Wilson, Emma. "Force response of locust skeletal muscle." Thesis, University of Southampton, 2010. https://eprints.soton.ac.uk/190857/.

Texto completo

Resumen

The force response of the locust hind leg extensor muscle to input excitation pulses is modelled. Despite the processes behind muscle contraction being well established, no broadly valid method of modelling skeletal muscle exists. Studies that compare the merits of existing models are extremely scarce and researchers make various assumptions in order to simplify the complex, nonlinear behaviour of the muscle. Locusts provide an opportunity to develop a muscle model in a simpler system, that will still show similar properties to that of mammalian muscles. In developing a model previous work is

Los estilos APA, Harvard, Vancouver, ISO, etc.

43

Metzger, Sabrina Kinzie. "Modeling of excitation in skeletal muscle." Wright State University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=wright1620983611677044.

Texto completo

Los estilos APA, Harvard, Vancouver, ISO, etc.

44

England, Eric M. "Postmortem metabolism in porcine skeletal muscle." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/54580.

Texto completo

Resumen

Once an animal is harvested for meat, skeletal muscle attempts to maintain ATP at or near antemortem levels. To maintain ATP levels postmortem, stored glycogen is catabolized to produce ATP through glycolysis and possibly oxidative metabolism. Hydrolysis of the produced ATP acidifies muscle until an ultimate pH is reached. The ultimate pH of meat directly impacts the quality characteristics of color, texture, and water holding capacity. Therefore, our research intends to describe the contributions glycolysis and oxidative metabolism play in determining ultimate pH and fresh meat quality. Tradi

Los estilos APA, Harvard, Vancouver, ISO, etc.

45

Myhal, Mark. "Skeletal muscle, age, overload, and oxandrolone/." The Ohio State University, 1999. http://rave.ohiolink.edu/etdc/view?acc_num=osu1488190109868676.

Texto completo

Los estilos APA, Harvard, Vancouver, ISO, etc.

46

Johnston, Nicholas Ian Falkinder. "Arginine vasopressin in foetal skeletal muscle." Thesis, University of Edinburgh, 2000. http://hdl.handle.net/1842/22358.

Texto completo

Resumen

Arginine vasopressin (AVP) is also known as anti-diuretic hormone (ADH). The two major effects of this peptide, that of increasing blood pressure by vasoconstriction and reducing water loss by promoting water re-absorption in the kidney, are described as its primary functions. But other effects of AVP have been demonstrated. For example, in the adult mammal AVP has a role in platelet aggregation, hepatic glycogenloysis, and memory consolidation, and the purpose of the course of study described in this thesis was to examination a putative alternative function for AVP. In certain rat myogenic ce

Los estilos APA, Harvard, Vancouver, ISO, etc.

47

Fry, William Mark. "K+ channels in Xenopus skeletal muscle /." St. John's NF : [s.n.], 2001.

Buscar texto completo

Los estilos APA, Harvard, Vancouver, ISO, etc.

48

Needham, Elise. "Personalised phosphoproteomics of skeletal muscle metabolism." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/28191.

Texto completo

Resumen

Protein phosphorylation dynamically integrates environmental and intracellular information to control virtually all biological processes. Challenges in determining the upstream regulation and downstream effects of phosphorylation obscures our functional understanding of cellular communication. In this thesis, I developed approaches to contextualise and prioritise phosphorylation events, focusing on the dynamic regulation of skeletal muscle metabolism by insulin and exercise. I measured phosphoproteomes of an in vitro panel of exercise-like stimuli to dissect upstream influences on exercise sig

Los estilos APA, Harvard, Vancouver, ISO, etc.

49

Ebert, Scott Matthew. "Molecular mechanisms of skeletal muscle atrophy." Diss., University of Iowa, 2012. https://ir.uiowa.edu/etd/4967.

Texto completo

Resumen

Skeletal muscle atrophy is a common and often debilitating complication of diverse stresses including muscle disuse, fasting, aging, critical illness and many chronic illnesses. However, the pathogenesis of muscle atrophy is still poorly understood. The thesis herein describes my studies investigating the molecular mechanisms of skeletal muscle atrophy. Using mouse skeletal muscle and cultured skeletal myotubes as experimental systems, I discovered a novel stress-induced pathway in skeletal muscle that causes muscle atrophy. The pathway begins with stress-induced expression of ATF4, a basic le

Los estilos APA, Harvard, Vancouver, ISO, etc.

50

Simmers, Jessica L. "nNos localization, muscle function and atrophy in skeletal muscle disorders." Thesis, The Johns Hopkins University, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3573097.

Texto completo

Resumen

<p>In skeletal muscle, loss of neuronal nitric oxide synthase (nNOS) from the sarcolemma has been observed in a few muscular dystrophies and myopathies. However, the extent of this phenomenon, its mechanism, and its physiological impact are not well understood. Using immunofluorescent staining for nNOS, a survey of 161 patient biopsies found absent or reduced sarcolemmal nNOS in 43% of patients. Patient mobility and muscle functional status correlated with nNOS mislocalization from the sarcolemma. Mouse models of inherited and acquired myopathies showed similar loss of sarcolemmal nNOS and imp

Los estilos APA, Harvard, Vancouver, ISO, etc.

Ofrecemos descuentos en todos los planes premium para autores cuyas obras están incluidas en selecciones literarias temáticas. ¡Contáctenos para obtener un código promocional único!