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1

Peng, Qiao, and Miao Tong. "Slack Channels as Key Regulators of Neuronal Excitability: Implications for Neural Function and the Link to Epilepsy Pathogenesis." Clinical Neuroscience Research 2, no. 3 (2024): 1–8. http://dx.doi.org/10.26689/cnr.v2i3.8001.

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The Slack channel encoded by the KCNT1 gene is a sodium-activated potassium channel. By regulating the flow of potassium ions, the Slack channel affects the membrane potential and discharge activity of neurons, thus participating in regulating neuronal excitability. Therefore, it plays a crucial role in maintaining the normal function of the nervous system. Consequently, abnormal Slack channel function is closely linked to various neurological diseases, such as epilepsy. Currently, quinidine-based medication therapy and neuroregulatory therapy are key components of the treatment of epilepsy re
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2

Fonseka, M. M., G.-L. Tian, X. Yang, and R. L. T. N. Rajapakse. "The interactions between different types of financial and human resource slacks on firm performance: Evidence from a developing country." South African Journal of Business Management 45, no. 3 (2014): 57–66. http://dx.doi.org/10.4102/sajbm.v45i3.131.

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This paper investigates the effect of both FS and HR slack together on firm performance and how different levels of these slack resources affect performance of private-owned enterprises (POEs) and state-owned enterprises (SOEs). Hypotheses are tested using a longitudinal data set of 11,985 listed Chinese companies from 2000 to 2009. Findings reveal that the unabsorbed-financial slack and HR slack show an inverse U shape relationship on firm performance for both POEs and SOEs. However, a less-negative interaction occurs for unabsorbed-financial and HR slacks for POEs. The absorbedfinancial and
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3

Kaczmarek, Leonard K. "Slack, Slick, and Sodium-Activated Potassium Channels." ISRN Neuroscience 2013 (May 13, 2013): 1–14. http://dx.doi.org/10.1155/2013/354262.

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The Slack and Slick genes encode potassium channels that are very widely expressed in the central nervous system. These channels are activated by elevations in intracellular sodium, such as those that occur during trains of one or more action potentials, or following activation of nonselective cationic neurotransmitter receptors such as AMPA receptors. This review covers the cellular and molecular properties of Slack and Slick channels and compares them with findings on the properties of sodium-activated potassium currents (termed KNa currents) in native neurons. Human mutations in Slack chann
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4

Connor, Margaret A., Stephanie Tarvin, Megan Quail, and Sven Peter Batke. "Plant diversity and community composition in managed humid coastal dune slacks in NW England." PLOS ONE 16, no. 8 (2021): e0256215. http://dx.doi.org/10.1371/journal.pone.0256215.

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Humid coastal dune slacks are an endangered habitat in Northwestern Europe. In the UK, dune slacks are currently classified as being in ‘unfavourable’ condition, with projected decrease in England of up to 30% by 2036. Studies in mainland Europe suggest that regional factors (e.g. slack area, age, and isolation) are more important than local factors (e.g. soil, pH, soil nutrient and water status) in driving successional vegetation processes in coastal slacks. However, this has never been tested for the UK, where approximately 14% of European slacks occur. We used previously established survey
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5

Dinh, Thi Thanh Binh, Thuy Anh Tu, and Thi Mai Phuong Chu. "Slack Resources and Export Intensity: New Empirical Evidence from Vietnam." Economies 11, no. 2 (2023): 68. http://dx.doi.org/10.3390/economies11020068.

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The paper explored the effects of financial and human resource slacks on firms’ export intensity. Using longitudinal data of Vietnamese firms with a random effect model, the study found that financial slack had an inverted-U shaped effect; meanwhile, human resource slack had no consistently significant effect on firms’ export intensity. The empirical findings could have managerial practice implications at the firm level. Too few—or too many—slack resources are bad for export intensity. Therefore, firm managers need to consider the necessary level of redundancy for slack resources to avoid prod
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6

Kim, Shin, Shin, and Park. "Organizational Slack, Corporate Social Responsibility, Sustainability, and Integrated Reporting: Evidence from Korea." Sustainability 11, no. 16 (2019): 4445. http://dx.doi.org/10.3390/su11164445.

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This paper examines whether organizational slack is associated with firms’ voluntary disclosure of corporate social responsibility (CSR), sustainability, and integrated reporting. This is an empirical research study using archival data based on a sample of public firms listed on the Korea Exchange from 2005 to 2016. We manually collected CSR reports, sustainability reports, and integrated reports (IRs) that were published during our sample period. We found that human resource slack was highly related to the publication of corporate social responsibility, sustainability, and integrated reports.
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7

Putra, I. Gede Eka Dharma, and Danang Mintoyuwono. "PENGARUH PARTISIPASI ANGGARAN, PENEKANAN ANGGARAN, DAN KOMITMEN ORGANISASI TERHADAP SENJANGAN ANGGARAN PADA SUKU DINAS PEMERINTAHAN DI DKI JAKARTA." Equity 20, no. 2 (2019): 59. http://dx.doi.org/10.34209/equ.v20i2.625.

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The study aims to determine the influence of budgetary participation, budget emphasis and organisation commitment on budgetary slcak. Respondents were studied were departement chief, head of subsection, and section chief in departements at west jakarta, south jakarta, north jakarta, central jakarta, and east jakarta . Data collection techniques in this research using primary data by distributing questionnaires to 211 respondents. Technique data processing was performed using SPSS 21 and assisted by using microsoft office 2010. The variables studied consisted of budgetary participation, budget
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8

Rothberg, Brad S. "A slick, slack pathway through the pore." Journal of Physiology 595, no. 7 (2017): 2337–38. http://dx.doi.org/10.1113/jp273497.

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9

Murro, Eduardo Vinícius Bassi, Guilherme Bittencourt Teixeira, Ilse Maria Beuren, Luciano Márcio Scherer, and Gerlando Augusto Sampaio Franco de Lima. "RELATIONSHIP BETWEEN ORGANIZATIONAL SLACK AND INNOVATION IN COMPANIES OF BM&FBOVESPA." RAM. Revista de Administração Mackenzie 17, no. 3 (2016): 132–57. http://dx.doi.org/10.1590/1678-69712016/administracao.v17n3p132-157.

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ABSTRACT Purpose: The goal of this study is to identify the relationship of absorbed, non-absorbed and potential slack with the innovation of companies of sectors members of the sectoral ranking of innovation in the Brazilian Index of Innovation (IBI) listed in BM&FBovespa. Originality/gap/relevance/implications: Organizational slack and innovation have been objects of study internationally, but still represent a research gap in Brazil. Also there were not identified studies using the intangible asset to measure innovation and the possible relations with the organizational slack measures.
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10

Harvey T. Ong. "The Impact of Management Information System’s Organizational Slack to Syngenta Company." Journal of Electrical Systems 20, no. 5s (2024): 1685–96. http://dx.doi.org/10.52783/jes.2503.

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Management information systems (MIS) is the usage of information systems at the operational, tactical, and strategic levels so that businesses are aided in the achievement of goals. (Oprea, 2007) While the use of MIS is already quite common, its many benefits have lately piqued the interest of researchers particularly on the phenomenon of slack. Companies typically prefer to remove slack as it has suffered from a negative reputation. However, recent studies by Bae and Rhee (2014) as well as by Heng, Ding, Guo, and Luo (2014) have shown that slack actually leads to innovation. It is because of
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11

Sabirin, Sabirin. "THE EFFECT OF PARTICIPATORY BUDGETING, INFORMATION ASYMETRICITY ON THE SLACK BUDGET AND THEIR IMPACT ON COMPANY PERFORMANCE LEVEL." Accounting and Finance Studies 1, no. 4 (2021): 1–22. http://dx.doi.org/10.47153/afs14.1942021.

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This study aims to analyze the effect of participatory budgeting variables and information asymmetry on budgetary slack, and to analyze the effect of participatory budgeting and information asymmetry variables on company performance through budgetary slack. This research is causal (causal research). The study population is all offices of PT Angkasa Pura II (Persero) in Indonesia. The sample consists of a number of members selected from the population. The sampling technique used in this study is non probability sampling, that is total sampling. In this research a descriptive statistical analys
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12

Dewi, Ni Putu Sintya Purnama, and Dewa Gede Wirama. "Debt covenant slack, earnings management, and value relevance of accounting information." International research journal of management, IT and social sciences 6, no. 4 (2019): 86–96. http://dx.doi.org/10.21744/irjmis.v6n4.661.

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This study aims to examine the effect of debt covenant slack on the value relevance of accounting information, and whether earnings management works as an intervening variable. A total of 40 non-financial companies listed in Indonesia Stock Exchange from 2013 to 2017 were selected as sample. Three hypotheses were tested using partial least square and analyzed via path analysis. This study found that debt covenant slack positively affects the value relevance of accounting information. Possibly, the tendency of small debt covenant slacks in the firms causing the information of firms’ performance
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13

Tejada, Maria de los Angeles, Lars Jørn Jensen, and Dan A. Klaerke. "PIP2 modulation of Slick and Slack K+ channels." Biochemical and Biophysical Research Communications 424, no. 2 (2012): 208–13. http://dx.doi.org/10.1016/j.bbrc.2012.06.038.

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14

Fields, Brian, Rastislav Bodík, and Mark D. Hill. "Slack." ACM SIGARCH Computer Architecture News 30, no. 2 (2002): 47–58. http://dx.doi.org/10.1145/545214.545222.

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15

Yang, Ting, Fei Luo, Joel Fuentes, Weichao Ding, and Chunhua Gu. "A Flexible Reinforced Bin Packing Framework with Automatic Slack Selection." Mathematical Problems in Engineering 2021 (May 19, 2021): 1–15. http://dx.doi.org/10.1155/2021/6653586.

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The slack-based algorithms are popular bin-focus heuristics for the bin packing problem (BPP). The selection of slacks in existing methods only consider predetermined policies, ignoring the dynamic exploration of the global data structure, which leads to nonfully utilization of the information in the data space. In this paper, we propose a novel slack-based flexible bin packing framework called reinforced bin packing framework (RBF) for the one-dimensional BPP. RBF considers the RL-system, the instance-eigenvalue mapping process, and the reinforced-MBS strategy simultaneously. In our work, the
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16

Tang, Fengzhen, Peter Tiňo, Pedro Antonio Gutiérrez, and Huanhuan Chen. "The Benefits of Modeling Slack Variables in SVMs." Neural Computation 27, no. 4 (2015): 954–81. http://dx.doi.org/10.1162/neco_a_00714.

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In this letter, we explore the idea of modeling slack variables in support vector machine (SVM) approaches. The study is motivated by SVM+, which models the slacks through a smooth correcting function that is determined by additional (privileged) information about the training examples not available in the test phase. We take a closer look at the meaning and consequences of smooth modeling of slacks, as opposed to determining them in an unconstrained manner through the SVM optimization program. To better understand this difference we only allow the determination and modeling of slack values on
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17

Jin, Ling, Jun Hyeok Choi, Saerona Kim, and Kwanghee Cho. "Slack Resources, Corporate Performance, and COVID-19 Pandemic: Evidence from China." International Journal of Environmental Research and Public Health 19, no. 21 (2022): 14354. http://dx.doi.org/10.3390/ijerph192114354.

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COVID-19 has caused tremendous damage to global economies, and similar health crises are expected to happen again. This study tests whether slack resources would enable companies to prepare for such uncertainties. Specifically, we explored the influence of the COVID-19 patient occurrence on corporate financial performance and the buffering effect of financial slacks using Chinese listed companies’ data during 2021. We also examined whether this effect differs across firms’ financial health and industry. Test results are as follows. First, consistent with the recent studies on pandemics, the de
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18

El Kadiri Boutchich, Driss. "Human capital in public research laboratories: a method proposal for assessing actual and target scores." Journal of Applied Research in Higher Education 12, no. 5 (2020): 1189–208. http://dx.doi.org/10.1108/jarhe-05-2019-0107.

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PurposeThis work aims to propose an alternative method of human capital calculation for research laboratories of public university, taking into account some drawbacks of the methods currently applied in this field.Design/methodology/approachThis method is implemented via a linear program extracted from Data Envelopment Analysis based on slack movement. This is the formulation of Copper et al. (2000), which is used as the starting point for developing the proposed method through important transformations.FindingsThe proposed method is supported by an illustration related to a Moroccan public un
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19

Dong, Xinyang, Gang Chen, Mingsong Lv, Weiguang Pang, and Wang Yi. "Flexible Mixed-Criticality Scheduling with Dynamic Slack Management." Journal of Circuits, Systems and Computers 30, no. 10 (2021): 2150306. http://dx.doi.org/10.1142/s0218126621503060.

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Mixed-criticality (MC) system has attracted a lot of research attention in the past few years for its resource efficiency. Recent work attempted to provide a new MC model, the so-called Flexible Mixed-Criticality (FMC) task model, to relax the pessimistic assumptions in classic MC scheduling. However, in FMC, the behavior of MC tasks is still analyzed in offline stage. The run-time behavior such as dynamic slack has not yet been studied in FMC scheduling framework. In this paper, we present a utilization-based slack scheduling framework for FMC tasks. In particular, we monitor task execution o
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20

Martins, Sara Varandas, Helene Burningham, and Carla Pinto-Cruz. "Climate variability impacts on coastal dune slack ecohydrology." Irish Geography 51, no. 2 (2019): 261–84. http://dx.doi.org/10.55650/igj.2018.1374.

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The hydrological regime of freshwater systems plays a crucial role in shaping the dynamics of the different biological communities that inhabit them. Climate change is expected to cause major alterations in the hydrological regime of dune slacks by producing shifts in temperature, precipitation and evapotranspiration. Across seasons, we explore the controls on common water fleas (Cladocera) and aquatic plant communities relative to water level regime, water chemistry, weather and geomorphological setting, in a slack of the Sheskinmore dune system, Co. Donegal, northwest Ireland. Cladoceran abu
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21

Ibrahim, Rofi Dwi Bagus, and Ika Putri Larasati. "SLACK RESOURCES AND CORPORATE SUSTAINABILITY PERFORMANCE." JURNAL AKUNTANSI UNIVERSITAS JEMBER 22, no. 1 (2024): 1. http://dx.doi.org/10.19184/jauj.v22i1.47831.

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ABSTRACTCorporate Sustainability Performance (CSP) is an important issue and has received considerable attention from stakeholders. CSP practices require the availability of resources from the company. Slack resources are surplus resources in a company that can be utilized for CSP. Slack resources in this research are classified into financial slack and Human Resources (HR) slack. This research aims to examine the role of financial slack and HR slack on CSP. The number of samples in this research was 250 non-financial companies that publish sustainability reports and annual reports and are lis
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22

Seliskar, Denise M. "The role of waterlogging and sand accretion in modulating the morphology of the dune slack plant Scirpus americanus." Canadian Journal of Botany 68, no. 8 (1990): 1780–87. http://dx.doi.org/10.1139/b90-230.

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Scirpus americanus Pers., a major dune slack plant in coastal sand dune ecosystems, differs in height along transects ranging between the lowest and highest elevational areas of slacks located along the coast of Delaware, U.S.A. Using reciprocal transplant and common garden experiments, results suggest that environmental factors rather than hereditary traits are more important in accounting for the differences in plant morphology expressed in the field. Dune slack plants are exposed to stresses of waterlogging and sand accretion in their natural environment. In controlled greenhouse experiment
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23

Sayekti, Yosefa. "The Effect of Slack Resources on Strategic Corporate Social Responsibility (CSR): Empirical Evidence on Indonesian Listed Companies." GATR Global Journal of Business Social Sciences Review 5, no. 2 (2017): 70–75. http://dx.doi.org/10.35609/gjbssr.2017.5.2(12).

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Objective - This study examines the effect of companies' slack resources on strategic Corporate Social Responsibility ('CSR') and also non-strategic CSR. By analysing the slack resources as a determinant of CSR, it might indicate the companies' priority regarding their strategic CSR as part of companies' strategy. Methodology/Technique - Instead of using profitability as a measure of slack resources, this study employs slack resources as a variable itself as it was developed by Burgeois (1981), based on financial data in the companies' financial statements. Findings - The empirical result of t
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24

Guha, Mahua. "Organizational slack in declining firms and surviving firms." Journal of Strategy and Management 9, no. 1 (2016): 93–114. http://dx.doi.org/10.1108/jsma-11-2014-0092.

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Purpose – There is a preponderance of evidence in the established literature that declining firms have lower levels of organizational slack when compared with surviving firms. To further advance the current literature, the purpose of this paper is to examine whether or not organizational slack in its various forms differ in declining firms and in surviving firms. Additionally, this study examines whether there is a change in the extent of slack in the declining firms in the years immediately preceding bankruptcy filing. Design/methodology/approach –t-tests and panel regressions with random eff
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25

Colaianni, C. Alessandra. "Slack Tide." New England Journal of Medicine 386, no. 2 (2022): 102–3. http://dx.doi.org/10.1056/nejmp2111782.

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26

Hilley, Sarah, and Jón Adólf Steinólfsson. "Slack Space." Infosecurity Today 2, no. 2 (2005): 54. http://dx.doi.org/10.1016/s1742-6847(05)70191-9.

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27

Jonsson, Ernst. "Ineffective slack." Scandinavian Journal of Management Studies 3, no. 2 (1986): 111–19. http://dx.doi.org/10.1016/0281-7527(86)90023-x.

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28

Sautter, Joachim. "Budgetary Slack." Controlling 28, no. 4-5 (2016): 281–82. http://dx.doi.org/10.15358/0935-0381-2016-4-5-281.

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29

Overmans, Tom. "Innovative austerity management." Journal of Public Budgeting, Accounting & Financial Management 30, no. 4 (2018): 350–67. http://dx.doi.org/10.1108/jpbafm-04-2018-0035.

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Purpose The purpose of this paper is to uncover the right type of organizational slack for innovation. It examines how city managers conceive slack, and how they create slack to facilitate innovation while dealing with fiscal stress. Design/methodology/approach The study is built around a comparative case study approach to uncover contrasts, similarities and patterns of slack-building for innovation in austere times. It relies on the experiences of 12 experienced city managers. Data are sought from elite interviews and one focus group. Findings The main finding is that innovation in the public
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30

Helmayunita, Nayang, and Ade Elsa Betavia. "PENGARUH SKEMA KOMPENSASI, SELF EFFICACY DAN PENALARAN MORAL TERHADAP SLACK BUDGETING." Jurnal Aplikasi Akuntansi 4, no. 1 (2019): 77–96. http://dx.doi.org/10.29303/jaa.v4i1.68.

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This study aims to examine the effect of compensation schemes, self efficacy and moral reasoning on slack budgeting. In this study the hypothesis is proposed that in the slack inducing compensation scheme the slack budgeting will be greater than using the truth inducing compensation scheme, then managers with low self efficacy will do slack budgeting compared to those with high self efficacy. It is also proposed that the individual with low moral reasoning will do slack budgeting rather than the individual with high moral reasoning. The research design in this study was a quasi 2 x 2 laborator
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31

Chen, H., J. Kronengold, Y. Yan, et al. "The N-Terminal Domain of Slack Determines the Formation and Trafficking of Slick/Slack Heteromeric Sodium-Activated Potassium Channels." Journal of Neuroscience 29, no. 17 (2009): 5654–65. http://dx.doi.org/10.1523/jneurosci.5978-08.2009.

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32

Santi, C. M. "Opposite Regulation of Slick and Slack K+ Channels by Neuromodulators." Journal of Neuroscience 26, no. 19 (2006): 5059–68. http://dx.doi.org/10.1523/jneurosci.3372-05.2006.

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de los, Maria, Angeles Tejada, Lars Jørn Jensen, and Dan A. Klaerke. "Phosphoinositides Control the Activity of Slick and Slack K+ Channels." Biophysical Journal 102, no. 3 (2012): 692a. http://dx.doi.org/10.1016/j.bpj.2011.11.3756.

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34

Sinaldi, Anjelika Harniaty, Akhmad Riduwan, and Maswar Patuh Priyadi. "Effect Of Moral Equity, Locus Of Control, Environmental Uncertainty, Organizational Commitment, Reward, And Motivation On Budgetary Slack: Participatory Budgeting As A Moderating Variable." Lead Journal of Economy and Administration 2, no. 1 (2023): 22–41. http://dx.doi.org/10.56403/lejea.v2i1.122.

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This study aimed to examine and analyze the effect of moral equity, locus ofcontrol, environment uncertainty, organizational commitment, reward, andmotivation onbudgetary slack: participative budgeting as a moderating variable. The population was all employees who worked at Local Government Organization in East Manggarai Sub-district. Moreover, the data collection technique used purposive sampling. In line with that, there were 115 employees as the sample. Furthermore, the instrument in the data collection technique used questionnaires. The research was quantitative. Additionally, the data ana
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35

Beuren, Ilse Maria, Franciele Beck, and Fabiane Popik. "Do Shared Interests Affect the Accuracy of Budgets?" Revista Contabilidade & Finanças 26, no. 67 (2015): 11–26. http://dx.doi.org/10.1590/1808-057x201512090.

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The creation of budgetary slack is a phenomenon associated with various behavioral aspects. This study focuses on accuracy in budgeting when the benefit of the slack is shared between the unit manager and his/her assistant. In this study, accuracy is measured by the level of slack in the budget, and the benefit of slack represents a financial consideration for the manager and the assistant. The study aims to test how shared interests in budgetary slack affect the accuracy of budget reports in an organization. To this end, an experimental study was conducted with a sample of 90 employees in man
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36

Huang, Cheng-Li, and Mien-Ling Chen. "The Effect of Attitudes Towards the Budgetary Process on Attitudes Towards Budgetary Slack and Behaviors to Create Budgetary Slack." Social Behavior and Personality: an international journal 37, no. 5 (2009): 661–71. http://dx.doi.org/10.2224/sbp.2009.37.5.661.

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In this study more positive attitudes towards the budgetary process are examined to see whether or not these cause less favorable attitudes towards budgetary slack, and whether less favorable attitudes towards budgetary slack causes or are caused by behaviors intended to create budgetary slack. The effects are tested using a structural equation model based on questionnaire data gained from 216 Taiwanese managers. The results indicate that more positive attitudes towards the budgetary process result in attitudes less favorable towards budgetary slack. A more favorable attitude towards budgetary
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37

Matt, Lucas, Thomas Pham, David Skrabak, et al. "The Na+-activated K+ channel Slack contributes to synaptic development and plasticity." Cellular and Molecular Life Sciences 78, no. 23 (2021): 7569–87. http://dx.doi.org/10.1007/s00018-021-03953-0.

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AbstractHuman mutations of the Na+-activated K+ channel Slack (KCNT1) are associated with epilepsy and intellectual disability. Accordingly, Slack knockout mice (Slack−/−) exhibit cognitive flexibility deficits in distinct behavioral tasks. So far, however, the underlying causes as well as the role of Slack in hippocampus-dependent memory functions remain enigmatic. We now report that infant (P6–P14) Slack−/− lack both hippocampal LTD and LTP, likely due to impaired NMDA receptor (NMDAR) signaling. Postsynaptic GluN2B levels are reduced in infant Slack−/−, evidenced by lower amplitudes of NMDA
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38

Marlin, Dan, and Scott W. Geiger. "The organizational slack and performance relationship: a configurational approach." Management Decision 53, no. 10 (2015): 2339–55. http://dx.doi.org/10.1108/md-03-2015-0100.

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Purpose – The purpose of this paper is to contribute to the organizational literature and improve the understanding of the slack and performance link by: examining the slack and performance relationship using a configurational approach and by considering equifinality and its possible effects on this relationship. Design/methodology/approach – Using cluster analysis, ANCOVA, and means comparisons this study identifies different configurations of slack and their associated performance implications. Findings – The results show that configurations with higher levels of slack outperform those with
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39

Zhuang, Chenfei, Noraizah Binti Abu Bakar, and Norhayati Binti Alias. "Determinants of Budgetary Slack and Its Impact on Organizational Performance." Malaysian Journal of Social Sciences and Humanities (MJSSH) 10, no. 3 (2025): e003312. https://doi.org/10.47405/mjssh.v10i3.3312.

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Budgetary slack is a common phenomenon in corporate budget management, characterized by management intentionally underestimating revenues or overestimating costs during the budgeting process to create a financial cushion. Organizations need to be mindful of the potential negative consequences of excessive budgetary slack, which can undermine financial stability and transparency. This article aims to identify and analyze the key factors influencing budgetary slack and examine its impact on organizational performance. Using a review analysis approach, we investigated the determinants of budgetar
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40

Sgourev, Stoyan V., and Wim van Lent. "When too many are not enough: Human resource slack and performance at the Dutch East India Company (1700–1795)." Human Relations 70, no. 11 (2017): 1293–315. http://dx.doi.org/10.1177/0018726717691340.

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Slack is an elusive concept in organizational research, with studies documenting a variety of relationships between slack and firm performance. We advocate treating slack not as a resource, but as a practice – a sequence of events and responses over time. A longitudinal analysis of the Dutch East India Company (1700–1795) highlights the use of slack as a response to a resource constraint (the shortage of skilled labor). After documenting the negative performance effects of skill shortage, we identify a trade-off in the use of human resource slack (number of sailors above what is operationally
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41

Zhou, Fangyuan, Katharina Metzner, Patrick Engel, et al. "Slack Potassium Channels Modulate TRPA1-Mediated Nociception in Sensory Neurons." Cells 11, no. 10 (2022): 1693. http://dx.doi.org/10.3390/cells11101693.

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The transient receptor potential (TRP) ankyrin type 1 (TRPA1) channel is highly expressed in a subset of sensory neurons where it acts as an essential detector of painful stimuli. However, the mechanisms that control the activity of sensory neurons upon TRPA1 activation remain poorly understood. Here, using in situ hybridization and immunostaining, we found TRPA1 to be extensively co-localized with the potassium channel Slack (KNa1.1, Slo2.2, or Kcnt1) in sensory neurons. Mice lacking Slack globally (Slack−/−) or conditionally in sensory neurons (SNS-Slack−/−) demonstrated increased pain behav
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42

Lu, Ruirui, Katharina Metzner, Fangyuan Zhou, et al. "Functional Coupling of Slack Channels and P2X3 Receptors Contributes to Neuropathic Pain Processing." International Journal of Molecular Sciences 22, no. 1 (2021): 405. http://dx.doi.org/10.3390/ijms22010405.

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The sodium-activated potassium channel Slack (KNa1.1, Slo2.2, or Kcnt1) is highly expressed in populations of sensory neurons, where it mediates the sodium-activated potassium current (IKNa) and modulates neuronal activity. Previous studies suggest that Slack is involved in the processing of neuropathic pain. However, mechanisms underlying the regulation of Slack activity in this context are poorly understood. Using whole-cell patch-clamp recordings we found that Slack-mediated IKNa in sensory neurons of mice is reduced after peripheral nerve injury, thereby contributing to neuropathic pain hy
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43

Manal, Kurt, and Thomas S. Buchanan. "Subject-Specific Estimates of Tendon Slack Length: A Numerical Method." Journal of Applied Biomechanics 20, no. 2 (2004): 195–203. http://dx.doi.org/10.1123/jab.20.2.195.

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Tendon develops force proportional to the distance it is stretched beyond its slack length. Tendon slack length is an important parameter for musculoskeletal models because it can greatly affect estimations of muscle force. Unfortunately, tendon slack length is a difficult parameter to measure, and therefore values for it are not often reported in the literature. In this paper we present a numerical method for estimating tendon slack length from architectural parameters of the muscle. Specifically, tendon slack length is computed iteratively from musculotendon lengths determined when a corresp
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44

Sholehah, Nur Lazimatul Hilma, and Parmin Ishak. "Impact of Environmental Turbulence, Self-Esteem and Budget Emphasis on Budgetary Slack." QISTINA: Jurnal Multidisiplin Indonesia 1, no. 2 (2022): 73–81. http://dx.doi.org/10.57235/qistina.v1i2.132.

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This study aims to: (1) Find out how much influence environmental turbulence, self-esteem and budget emphasis have on budgetary slack; (2) Knowing how much environmental turbulence affects budgetary slack; (3) Knowing how much self-esteem affects budgetary slack; (4) Knowing how much influence budget emphasis has on budgetary slack. This type of research is quantitative research. The object of this study was an employee of the Boelamo Regency BKAD. The sampling technique in this study used a saturated sampling method. Data collection was carried out through a survey method using a questionnair
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45

Ishak, Parmin, and Nur Lazimatul Hilma Sholehah. "DAMPAK TURBULENSI LINGKUNGAN, SELF-ESTEEM DAN BUDGET EMPHASIS TERHADAP BUDGETARY SLACK." JOURNAL OF APPLIED MANAGERIAL ACCOUNTING 7, no. 1 (2023): 163–73. http://dx.doi.org/10.30871/jama.v7i1.4853.

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The study aims for: (1) to know how much environmental turbulence, self-esteem and budget emphasis simultaneous affect the slack budgetary; (2) know how much environmental turbulence affects the slack budgetary; (3) know how much self-esteem affects the slack budgetary; (4) knows how much the budget emphasis affects the slack budgetary. This kind of research is quantitative research. The object of this research is boelamo district BKAD. The sample sampling technique in this study is using the tedium sampling method. Data collection was conducted via a survey method using a questionnaire that w
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46

Dharmawan, Yoana, and Made Gede Wirakusuma. "Karakteristik Personal dalam Memoderasi Pengaruh Penganggaran Partisipatif dan Ambiguitas Peran pada Senjangan Anggaran." E-Jurnal Akuntansi 31, no. 2 (2021): 360. http://dx.doi.org/10.24843/eja.2021.v31.i02.p08.

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This study aims to determine the role of personal characteristics in moderating the effect of participatory budgeting on budgetary slack and to determine the role of personal characteristics in moderating the influence of role ambiguity on budgetary slack. Data used is primer data, the analysis technique used in this study is Moderated Regression Analysis. The results of the analysis address personal characteristics which weaken the effect of participatory budgeting on budgetary slack. This shows that with good personal characteristics, participatory budgets will be able to reduce budgetary sl
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47

Yakub, Junaidi, Irfan Zamzam, and Johan Fahri. "Budgeting Participation and Organizational Commitment to Budgetary Gaps with Information Asymmetry as a Moderating Variable." Jurnal Economic Resource 5, no. 2 (2022): 260–71. http://dx.doi.org/10.57178/jer.v5i2.316.

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This research is quantitative research with simple regression analysis and moderate regression analysis. The objectives of this study: firstly, to analyze the effect of budgetary participation in budget slack, secondly, to analyze the effect of organizational commitment on budget slack, thirdly, to analyze the effect of budgetary participation on budget slack with information asymmetry as a moderating variable, fourthly, to analyze the effect of organizational commitment on the relationship between information asymmetry and budget slack. The sample in this study was 47 respondents in the Tidor
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48

Geiger, Scott W., Dan Marlin, and Sharon L. Segrest. "Slack and performance in the hospital industry: a configurational approach." Management Decision 57, no. 11 (2019): 2978–96. http://dx.doi.org/10.1108/md-07-2017-0703.

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Purpose The purpose of this paper is to contribute to the healthcare management literature and improve the understanding of the slack and performance link by examining the hospital slack and performance relationship using a sample of 148 US hospitals. Design/methodology/approach Using cluster analysis, ANCOVA and means comparisons, this study identifies different hospital slack configurations and their associated performance implications. Findings The results demonstrate that different configurations of slack resources result in different levels of hospital performance. The findings also demon
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49

Berezinets, Irina V., Egor D. Nikulin, and Vitaly L. Okulov. "Assessment of the feasibility of establishing financial slack in a company: The model and its empirical verification." Vestnik of Saint Petersburg University. Management 21, no. 4 (2022): 497–526. http://dx.doi.org/10.21638/11701/spbu08.2022.401.

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Financial slack refers to excessive financial resources of a company that exist in addition to those that are necessary for operating activities. Is it feasible for a company to create financial slack? The answer to this question is ambiguous. On the one hand, the existence of slack provides a company with resources that can be used, for example, in case of financial constraints or for investing. On the other hand, the creation of financial slack means that the underlying cash reserves cannot be used for other purposes, for example, for distribution to stockholders. The paper presents the mode
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50

Haliah, Haliah. "A study of performance model development and good governance budgeting." International Journal of Law and Management 63, no. 3 (2021): 301–19. http://dx.doi.org/10.1108/ijlma-11-2016-0122.

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Purpose The purpose of this study is to empirically examine the influence of politics, culture and regulation on the budgetary slack and its impact on performance. Specifically, the purpose of this study is to analyze the influence of culture, politics and regulation on budgetary slack and performance in local government. Design/methodology/approach Studies to develop model pengangaran good (good governance budgeting). Using the survey method. The total sample is 300 respondents in seven local governments in West Sulawesi. Respondents from the executive and legislative participate in the prepa
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