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Artículos de revistas sobre el tema "Synthèse guidée"

Autor: Grafiati

Publicado: 25 de mayo de 2024

Última modificación: 31 de julio de 2025

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1

Colas, Maxime, and Michel Deloizy. "Le Model Based Design pour l’apprentissage par conception guidée." J3eA 22 (2023): 1009. http://dx.doi.org/10.1051/j3ea/20231009.

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Cet article présente une démarche d’apprentissage par conception guidée reposant sur des techniques de prototypage rapide dans le domaine mécatronique. La pédagogie développée se veut intégrative et auto-contenue : elle ne nécessite pas de prérequis et apporte au fur et à mesure des besoins, l’ensemble des connaissances et compétences pluridisciplinaires nécessaires à la progression cohérente du projet de conception, tant d’un point de vue mécanique, programmation, qu’en termes de technique de contrôle-commande, le tout dans un volume horaire contraint. La ligne directrice employée vise à conf

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2

Landry, Rodrigue, and Omer Robichaud. "Un modèle heuristique pour l’individualisation de l’enseignement." Revue des sciences de l'éducation 11, no. 2 (2009): 295–317. http://dx.doi.org/10.7202/900496ar.

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Résumé Cet article a pour objet de montrer l’importance pour la pratique éducative d’être guidée par un cadre théorique global et cohérent. Le modèle théorique présenté s’inspire de la théorie générale des systèmes et donne à la fois une analyse et une synthèse du système éducatif. Le modèle définit les composantes universelles et essentielles de tout système d’enseignement. Ces composantes du système éducatif doivent converger vers un même but, soit l’apprentissage individualisé. Le modèle théorique présenté est surtout heuristique, cherchant à définir les principes fondamentaux d’un enseigne

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3

PAVAGEAU, S., A.-S. BREDILLET, A. LOPEZ, and M. GLONDUS-LASSIS. "La tolérance à l’incertitude lors d’une prise de décision est une compétence complexe du médecin généraliste." EXERCER 34, no. 195 (2023): 312–21. http://dx.doi.org/10.56746/exercer.2023.195.312.

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Contexte. L’incertitude est inhérente à l’exercice de la médecine générale. Face aux plaintes des patients, le médecin généraliste (MG) peut se sentir démuni, indécis, anxieux, et doit trouver un moyen d’intégrer cette incertitude dans sa prise de décision. Cette composante a été étudiée dans diverses études qualitatives. Objectif. Apporter une analyse compréhensive de l’incertitude dans la prise de décision en soins premiers, à partir d’une métasynthèse qualitative. Méthodes. Analyse secondaire des études qualitatives : 1) revue de la littérature avec sélection des études qualitatives selon d

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4

JAILLOT, S., A. SAVALL, C. PLOTTON, and X. GOCKO. "LES RECITS DE SITUATION COMPLEXE AUTHENTIQUES SONT-ILS DES OUTILS PEDAGOGIQUES VALIDES ? EVALUATION STEPHANOISE." EXERCER 30, no. 156 (2019): 381–82. https://doi.org/10.56746/exercer.2019.156.381.

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Contexte : Dans le paradigme d’apprentissage qui régit le diplôme d’études spécialisées (DES) de médecine générale les traces écrites d’apprentissage (TEA) sont des outils d’évaluation formative et sommative. Une de ces TEA, le récit de situation complexe authentique (RSCA) est un outil commun à presque tous les départements de médecine générale. Un consensus formalisé national a permis l’obtention d’une grille critériée d’évaluation. À Saint-Étienne, le second RSCA demandé était présenté lors de la soutenance du DES. Pour juger de la validité de cet outil pédagogique, les contenus des RSCA pr

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5

Bouchafa, Samia. "Décision cumulative pour la vision dynamique des systèmes." Revue Française de Photogrammétrie et de Télédétection, no. 202 (April 16, 2014): 2–26. http://dx.doi.org/10.52638/rfpt.2013.48.

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Les travaux présentés dans cette synthèse portent essentiellement sur l'analyse de scènes à partir de caméras mobiles avec pour application immédiate l'apport d'une vision par ordinateur efficace dans les systèmes autonomes. Ils sont le fruit d'une décennie de recherches menées d'abord à l'INRETS (actuellement IFSTTAR : Institut français des sciences et technologies des transports, de l'aménagement et des réseaux ) puis à l'Université Paris Sud XI (Institut d'Électronique Fondamentale). L'idée initiale est que l'autonomie d'un système implique, ne serait-ce que pour raisons énergétiques, une f

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6

Chow, Jeng-Yeong, Bo-Xue Tian, Gurusankar Ramamoorthy, et al. "Computational-guided discovery and characterization of a sesquiterpene synthase from Streptomyces clavuligerus." Proceedings of the National Academy of Sciences 112, no. 18 (2015): 5661–66. http://dx.doi.org/10.1073/pnas.1505127112.

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Terpenoids are a large structurally diverse group of natural products with an array of functions in their hosts. The large amount of genomic information from recent sequencing efforts provides opportunities and challenges for the functional assignment of terpene synthases that construct the carbon skeletons of these compounds. Inferring function from the sequence and/or structure of these enzymes is not trivial because of the large number of possible reaction channels and products. We tackle this problem by developing an algorithm to enumerate possible carbocations derived from the farnesyl ca

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7

Arechaga, Ignacio, and Phil C. Jones. "Quick guide: ATP synthase." Current Biology 11, no. 4 (2001): R117. http://dx.doi.org/10.1016/s0960-9822(01)00055-0.

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8

Villadangos, Leticia, and Juan M. Serrador. "Subcellular Localization Guides eNOS Function." International Journal of Molecular Sciences 25, no. 24 (2024): 13402. https://doi.org/10.3390/ijms252413402.

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Nitric oxide synthases (NOS) are enzymes responsible for the cellular production of nitric oxide (NO), a highly reactive signaling molecule involved in important physiological and pathological processes. Given its remarkable capacity to diffuse across membranes, NO cannot be stored inside cells and thus requires multiple controlling mechanisms to regulate its biological functions. In particular, the regulation of endothelial nitric oxide synthase (eNOS) activity has been shown to be crucial in vascular homeostasis, primarily affecting cardiovascular disease and other pathophysiological process

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9

Bodel, Catherine, Philippe Delarue, and Robert Bausière. "Architectures multiniveaux : synthèse d'un guide de choix." Revue internationale de génie électrique 6, no. 1-2 (2003): 121–42. http://dx.doi.org/10.3166/rige.6.121-142.

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10

Bodel, Catherine, Philippe Delarue, and Robert Bausière. "Architectures multiniveaux : synthèse d'un guide de choix." Revue internationale de génie électrique 6, no. 3-4 (2003): 351–56. http://dx.doi.org/10.3166/rige.6.351-356.

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11

Ker, De-Sheng, Sze Lei Pang, Noor Farhan Othman та ін. "Purification and biochemical characterization of recombinant Persicaria minor β-sesquiphellandrene synthase". PeerJ 5 (28 лютого 2017): e2961. http://dx.doi.org/10.7717/peerj.2961.

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Background Sesquiterpenes are 15-carbon terpenes synthesized by sesquiterpene synthases using farnesyl diphosphate (FPP) as a substrate. Recently, a sesquiterpene synthase gene that encodes a 65 kDa protein was isolated from the aromatic plant Persicaria minor. Here, we report the expression, purification and characterization of recombinant P. minor sesquiterpene synthase protein (PmSTS). Insights into the catalytic active site were further provided by structural analysis guided by multiple sequence alignment. Methods The enzyme was purified in two steps using affinity and size exclusion chrom

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12

Maceluch, J., M. Kmieciak, Z. Szweykowska-Kulińska, and A. Jarmołowski. "Cloning and characterization of Arabidopsis thaliana AtNAP57--a homologue of yeast pseudouridine synthase Cbf5p." Acta Biochimica Polonica 48, no. 3 (2001): 699–709. http://dx.doi.org/10.18388/abp.2001_3904.

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Rat Nap57 and its yeast homologue Cbf5p are pseudouridine synthases involved in rRNA biogenesis, localized in the nucleolus. These proteins, together with H/ACA class of snoRNAs compose snoRNP particles, in which snoRNA guides the synthase to direct site-specific pseudouridylation of rRNA. In this paper we present an Arabidopsis thaliana protein that is highly homologous to Cbf5p (72% identity and 85% homology) and NAP57 (67% identity and 81% homology). Moreover, the plant protein has conserved structural motifs that are characteristic features of pseudouridine synthases of the TruB class. We

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13

Zinck, Garrett E., and Joe Chappell. "Structurally Guided Reprogramming of Valerenadiene Synthase." Biochemistry 60, no. 51 (2021): 3868–78. http://dx.doi.org/10.1021/acs.biochem.1c00523.

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14

Sinichich, Arseniy A., Danil V. Krivonos, Anna A. Baranova, et al. "Genome-Guided Metabolomic Profiling of Peptaibol-Producing Trichoderma." International Journal of Molecular Sciences 26, no. 12 (2025): 5599. https://doi.org/10.3390/ijms26125599.

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Peptaibols are linear fungal peptides featuring α,α-dialkylated amino acids (e.g., α-aminoisobutyric acid (Aib), isovaline (Iva)) and characteristic C-terminal alcohol groups. Despite their promising antibacterial and antiplasmodial activities, detailed biosynthetic studies remain limited. A genome-guided study of the fungus Trichodema sp. SK1-7, isolated from decaying wood, revealed the production of previously described trichorozin IV (1), along with novel SF4-type peptaibol 2 (trichorozin V). The structures of these compounds were elucidated through MS analysis, NMR study and advanced Marfe

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15

Bolster-Foucault, Claire, Brigitte Ho Mi Fane, and Alexandra Blair. "Déterminants structurels de la stigmatisation touchant les conditions sanitaires et sociales : revue rapide et cadre conceptuel visant à guider la recherche et les interventions." Promotion de la santé et prévention des maladies chroniques au Canada 41, no. 3 (2021): 93–128. http://dx.doi.org/10.24095/hpcdp.41.3.03f.

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Introduction On sait que la stigmatisation est un déterminant clé de la santé et des inégalités en matière de santé en raison de ses effets sur l’accès aux ressources favorables à la santé et sur l’exposition au stress. Alors que divers rapports offrent des synthèses approfondies des mécanismes par lesquels la stigmatisation influence la santé, il n’existe aucun examen des données probantes sur les facteurs en amont de la stigmatisation touchant les conditions sanitaires et sociales. L’objectif de cette étude consiste à réaliser une synthèse des déterminants structurels connus de la stigmatisa

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16

Chen, Jonathan L., W. Matthias Leeder, Pedro Morais, Hironori Adachi, and Yi-Tao Yu. "Pseudouridylation-mediated gene expression modulation." Biochemical Journal 481, no. 1 (2024): 1–16. http://dx.doi.org/10.1042/bcj20230096.

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RNA-guided pseudouridylation, a widespread post-transcriptional RNA modification, has recently gained recognition for its role in cellular processes such as pre-mRNA splicing and the modulation of premature termination codon (PTC) readthrough. This review provides insights into its mechanisms, functions, and potential therapeutic applications. It examines the mechanisms governing RNA-guided pseudouridylation, emphasizing the roles of guide RNAs and pseudouridine synthases in catalyzing uridine-to-pseudouridine conversion. A key focus is the impact of RNA-guided pseudouridylation of U2 small nu

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17

Lux, André. "Essai de synthèse." V. Dialectique des recherches urbaines 9, no. 1-2 (2005): 133–40. http://dx.doi.org/10.7202/055402ar.

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Les exposés de ce colloque et les discussions qu'ils ont suscitées ramènent sans cesse à l'esprit la question de savoir ce qu'est en définitive la ville comme phénomène sociologique dans notre société. En essayant d'y répondre, les participants se sont vus forcés de soulever d'autres questions qui apparaissent liées spontanément à celle-ci. Dès lors, il faut s'interroger sur la nature de ces liens pour leur trouver une ordonnance hiérarchique. En même temps, ces questions portent sur la validité d'une présentation dichotomique des différents aspects ainsi liés d'une réalité mouvante et ambival

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18

Bailey, Constance B., Marjolein E. Pasman, and Adrian T. Keatinge-Clay. "Substrate structure–activity relationships guide rational engineering of modular polyketide synthase ketoreductases." Chemical Communications 52, no. 4 (2016): 792–95. http://dx.doi.org/10.1039/c5cc07315d.

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Structure–activity relationship studies guided stereocontrol engineering within a modular polyketide synthase ketoreductase to yield a more active enzyme whose reactivity can be explained through the Felkin–Anh model.

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19

Kim, Hansol, Young Ji Kang, Junseon Min, Hyeokjune Choi, and Sebyung Kang. "Development of an antibody-binding modular nanoplatform for antibody-guided targeted cell imaging and delivery." RSC Advances 6, no. 23 (2016): 19208–13. http://dx.doi.org/10.1039/c6ra00233a.

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A polyvalent antibody-binding lumazine synthase protein cage nanoparticle (ABD–AaLS) is constructed by genetically fusing lumazine synthase and antibody-binding domains. ABD–AaLS effectively displays targeting antibodies in an orientation-controlled manner.

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20

Decatur, Wayne A., and Murray N. Schnare. "Different Mechanisms for Pseudouridine Formation in Yeast 5S and 5.8S rRNAs." Molecular and Cellular Biology 28, no. 10 (2008): 3089–100. http://dx.doi.org/10.1128/mcb.01574-07.

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ABSTRACT The selection of sites for pseudouridylation in eukaryotic cytoplasmic rRNA occurs by the base pairing of the rRNA with specific guide sequences within the RNA components of box H/ACA small nucleolar ribonucleoproteins (snoRNPs). Forty-four of the 46 pseudouridines (Ψs) in the cytoplasmic rRNA of Saccharomyces cerevisiae have been assigned to guide snoRNAs. Here, we examine the mechanism of Ψ formation in 5S and 5.8S rRNA in which the unassigned Ψs occur. We show that while the formation of the Ψ in 5.8S rRNA is associated with snoRNP activity, the pseudouridylation of 5S rRNA is not.

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21

Zargar, Amin, Ravi Lal, Luis Valencia, et al. "Chemoinformatic-Guided Engineering of Polyketide Synthases." Journal of the American Chemical Society 142, no. 22 (2020): 9896–901. http://dx.doi.org/10.1021/jacs.0c02549.

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22

Grünberg, Sebastian, Lindsey A. Doyle, Eric J. Wolf, et al. "The structural basis of mRNA recognition and binding by yeast pseudouridine synthase PUS1." PLOS ONE 18, no. 11 (2023): e0291267. http://dx.doi.org/10.1371/journal.pone.0291267.

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The chemical modification of RNA bases represents a ubiquitous activity that spans all domains of life. Pseudouridylation is the most common RNA modification and is observed within tRNA, rRNA, ncRNA and mRNAs. Pseudouridine synthase or ‘PUS’ enzymes include those that rely on guide RNA molecules and others that function as ‘stand-alone’ enzymes. Among the latter, several have been shown to modify mRNA transcripts. Although recent studies have defined the structural requirements for RNA to act as a PUS target, the mechanisms by which PUS1 recognizes these target sequences in mRNA are not well u

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23

Cogan, Dillon P., Graham A. Hudson, Zhengan Zhang, et al. "Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis." Proceedings of the National Academy of Sciences 114, no. 49 (2017): 12928–33. http://dx.doi.org/10.1073/pnas.1716035114.

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The [4+2] cycloaddition reaction is an enabling transformation in modern synthetic organic chemistry, but there are only limited examples of dedicated natural enzymes that can catalyze this transformation. Thiopeptides (or more formally thiazolyl peptides) are a class of thiazole-containing, highly modified, macrocyclic secondary metabolites made from ribosomally synthesized precursor peptides. The characteristic feature of these natural products is a six-membered nitrogenous heterocycle that is assembled via a formal [4+2] cycloaddition between two dehydroalanine (Dha) residues. This heteroan

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24

Khan, Adil. "Pseudouridine in RNA: Enzymatic Synthesis Mechanisms and Functional Roles in Molecular Biology." International Journal of Environment, Agriculture and Biotechnology 8, no. 6 (2023): 284–300. http://dx.doi.org/10.22161/ijeab.86.25.

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Pseudouridine, a common modified nucleotide, is prevalent in bacterial tRNA, rRNA, and snRNA. Initially identified in rRNA and tRNA, its presence extends to snRNA. Despite being the first identified and most prevalent RNA modification, its biosynthesis and diverse roles remain insufficiently understood. This extensively occurring modified nucleotide influences structural and functional attributes in various RNA categories. The isomerization process involves a carbon–carbon bond formation, and Pumilio family proteins (PUFs) are potential Ψ reader proteins. Pseudouridine, a ubiquitous constituen

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25

Hansen, Frederik T., Jens L. Sørensen, Henriette Giese, Teis E. Sondergaard, and Rasmus J. N. Frandsen. "Quick guide to polyketide synthase and nonribosomal synthetase genes in Fusarium." International Journal of Food Microbiology 155, no. 3 (2012): 128–36. http://dx.doi.org/10.1016/j.ijfoodmicro.2012.01.018.

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26

Dong, Shi-Hui, Mila Nhu-Lam, Rajesh Nagarajan, and Satish K. Nair. "Structure-Guided Biochemical Analysis of Quorum Signal Synthase Specificities." ACS Chemical Biology 15, no. 6 (2020): 1497–504. http://dx.doi.org/10.1021/acschembio.0c00142.

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27

Clavier, Carole, Maël Permal, France Gagnon, and Matthew Hunt. "Utiliser une banque de cas pour comprendre les politiques pour la santé publique et leurs enjeux éthiques." Canadian Journal of Bioethics 8, no. 1-2 (2025): 65–73. https://doi.org/10.7202/1117870ar.

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Cet article explore l’utilisation des banques de cas pour accompagner le développement de la compétence d’analyse des enjeux éthiques et du processus des politiques publiques en contexte d’apprentissage en santé publique. Une brève synthèse de la littérature souligne la pertinence des études de cas pour acquérir des connaissances empiriques ou développer des compétences d’analyse critique. Cependant, cette synthèse n’a pas permis d’identifier d’analyses de l’utilisation d’ensembles de cas, tels que des banques de cas. Pour combler ce manque, l’article présente PolÉthicas, une collection d’étud

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28

Adhikari, Kamal, I.-Wen Lo, Chun-Liang Chen, et al. "Chemoenzymatic Synthesis and Biological Evaluation for Bioactive Molecules Derived from Bacterial Benzoyl Coenzyme A Ligase and Plant Type III Polyketide Synthase." Biomolecules 10, no. 5 (2020): 738. http://dx.doi.org/10.3390/biom10050738.

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Plant type III polyketide synthases produce diverse bioactive molecules with a great medicinal significance to human diseases. Here, we demonstrated versatility of a stilbene synthase (STS) from Pinus Sylvestris, which can accept various non-physiological substrates to form unnatural polyketide products. Three enzymes (4-coumarate CoA ligase, malonyl-CoA synthetase and engineered benzoate CoA ligase) along with synthetic chemistry was practiced to synthesize starter and extender substrates for STS. Of these, the crystal structures of benzoate CoA ligase (BadA) from Rhodopseudomonas palustris i

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29

Balazs, Amber Y. S., Nichola L. Davies, David Longmire, Martin J. Packer, and Elisabetta Chiarparin. "Nuclear magnetic resonance free ligand conformations and atomic resolution dynamics." Magnetic Resonance 2, no. 1 (2021): 489–98. http://dx.doi.org/10.5194/mr-2-489-2021.

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Abstract. Knowledge of free ligand conformational preferences (energy minima) and conformational dynamics (rotational energy barriers) of small molecules in solution can guide drug design hypotheses and help rank ideas to bias syntheses towards more active compounds. Visualization of conformational exchange dynamics around torsion angles, by replica exchange with solute tempering molecular dynamics (REST-MD), gives results in agreement with high-resolution 1H nuclear magnetic resonance (NMR) spectra and complements free ligand conformational analyses. Rotational energy barriers around individu

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30

Gilroy, Kyle D., Hsin-Chieh Peng, Xuan Yang, Aleksey Ruditskiy, and Younan Xia. "Symmetry breaking during nanocrystal growth." Chemical Communications 53, no. 33 (2017): 4530–41. http://dx.doi.org/10.1039/c7cc01121k.

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31

Lancaster, Jason, Ashot Khrimian, Sharon Young, et al. "De novo formation of an aggregation pheromone precursor by an isoprenyl diphosphate synthase-related terpene synthase in the harlequin bug." Proceedings of the National Academy of Sciences 115, no. 37 (2018): E8634—E8641. http://dx.doi.org/10.1073/pnas.1800008115.

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Insects use a diverse array of specialized terpene metabolites as pheromones in intraspecific interactions. In contrast to plants and microbes, which employ enzymes called terpene synthases (TPSs) to synthesize terpene metabolites, limited information from few species is available about the enzymatic mechanisms underlying terpene pheromone biosynthesis in insects. Several stink bugs (Hemiptera: Pentatomidae), among them severe agricultural pests, release 15-carbon sesquiterpenes with a bisabolene skeleton as sex or aggregation pheromones. The harlequin bug, Murgantia histrionica, a specialist

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Moutereau, Stéphane, Stéphanie Vicca, and Camille Roussel. "Interprétation des variations de l’hémoglobine A2 (HbA2)." Revue de biologie médicale N° 374, no. 5 (2023): 31–47. http://dx.doi.org/10.3917/rbm.374.0031.

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Les hémoglobinopathies sont un ensemble de maladies héréditaires liées à des mutations des gènes de globine. On distingue les anomalies qualitatives (mutations responsables de la synthèse d’une hémoglobine anormale) et les anomalies quantitatives (mutations responsables d’une diminution de la synthèse d’une des chaînes de globine, appelées « thalassémies »). En France, dans le cadre de la recherche d’une anomalie de l’hémoglobine, il est recommandé de pratiquer au moins deux techniques séparatives, dont l’une doit être quantitative afin de doser les hémoglobines A2 et F. La quantification de l

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33

Lim, Soo-Hwan, Jong-In Baek, Byeong-Min Jeon, et al. "CRISPRi-Guided Metabolic Flux Engineering for Enhanced Protopanaxadiol Production in Saccharomyces cerevisiae." International Journal of Molecular Sciences 22, no. 21 (2021): 11836. http://dx.doi.org/10.3390/ijms222111836.

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Protopanaxadiol (PPD), an aglycon found in several dammarene-type ginsenosides, has high potency as a pharmaceutical. Nevertheless, application of these ginsenosides has been limited because of the high production cost due to the rare content of PPD in Panax ginseng and a long cultivation time (4–6 years). For the biological mass production of the PPD, de novo biosynthetic pathways for PPD were introduced in Saccharomyces cerevisiae and the metabolic flux toward the target molecule was restructured to avoid competition for carbon sources between native metabolic pathways and de novo biosynthet

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34

Huang, He, Huiying Li, Pavel Martásek, Linda J. Roman, Thomas L. Poulos, and Richard B. Silverman. "Structure-Guided Design of Selective Inhibitors of Neuronal Nitric Oxide Synthase." Journal of Medicinal Chemistry 56, no. 7 (2013): 3024–32. http://dx.doi.org/10.1021/jm4000984.

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Jez, Joseph M., Marianne E. Bowman, and Joseph P. Noel. "Structure-Guided Programming of Polyketide Chain-Length Determination in Chalcone Synthase†." Biochemistry 40, no. 49 (2001): 14829–38. http://dx.doi.org/10.1021/bi015621z.

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36

Leferink, Nicole G. H., Kara E. Ranaghan, Jaime Battye, et al. "Taming the Reactivity of Monoterpene Synthases To Guide Regioselective Product Hydroxylation." ChemBioChem 21, no. 7 (2020): 985–90. http://dx.doi.org/10.1002/cbic.201900672.

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Massenet, Séverine, Yuri Motorin, Denis L. J. Lafontaine, Eduard C. Hurt, Henri Grosjean, and Christiane Branlant. "Pseudouridine Mapping in the Saccharomyces cerevisiae Spliceosomal U Small Nuclear RNAs (snRNAs) Reveals that Pseudouridine Synthase Pus1p Exhibits a Dual Substrate Specificity for U2 snRNA and tRNA." Molecular and Cellular Biology 19, no. 3 (1999): 2142–54. http://dx.doi.org/10.1128/mcb.19.3.2142.

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ABSTRACT Pseudouridine (Ψ) residues were localized in theSaccharomyces cerevisiae spliceosomal U small nuclear RNAs (UsnRNAs) by using the chemical mapping method. In contrast to vertebrate UsnRNAs, S. cerevisiae UsnRNAs contain only a few Ψ residues, which are located in segments involved in intermolecular RNA-RNA or RNA-protein interactions. At these positions, UsnRNAs are universally modified. When yeast mutants disrupted for one of the several pseudouridine synthase genes (PUS1,PUS2, PUS3, and PUS4) or depleted in rRNA-pseudouridine synthase Cbf5p were tested for UsnRNA Ψ content, only the

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Nishimura, Sho, Kazune Nakamura, Miyako Yamamoto, Daichi Morita, Teruo Kuroda, and Takanori Kumagai. "Genome Sequence-Guided Finding of Lucensomycin Production by Streptomyces achromogenes Subsp. streptozoticus NBRC14001." Microorganisms 10, no. 1 (2021): 37. http://dx.doi.org/10.3390/microorganisms10010037.

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Information on microbial genome sequences is a powerful resource for accessing natural products with significant activities. We herein report the unveiling of lucensomycin production by Streptomyces achromogenes subsp. streptozoticus NBRC14001 based on the genome sequence of the strain. The genome sequence of strain NBRC14001 revealed the presence of a type I polyketide synthase gene cluster with similarities to a biosynthetic gene cluster for natamycin, which is a polyene macrolide antibiotic that exhibits antifungal activity. Therefore, we investigated whether strain NBRC14001 produces antif

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Chen, Yang, and Yu Cao. "The sphingomyelin synthase family: proteins, diseases, and inhibitors." Biological Chemistry 398, no. 12 (2017): 1319–25. http://dx.doi.org/10.1515/hsz-2017-0148.

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AbstractSphingomyelin (SM) is among the most important biomolecules in eukaryotes and acts as both constructive components and signal carrier in physiological processes. SM is catalyzed by a membrane protein family, sphingomyelin synthases (SMSs), consisting of three members, SMS1, SMS2 and SMSr. SMSs modulate sphingomyelin and other sphingolipids levels, thereby regulating membrane mobility, ceramide-dependent apoptosis and DAG-dependent signaling pathways. SMSs was found associated with various diseases. Downregulation of SMS2 activity results in protective effects against obesity, atheroscl

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40

Filippozzi, Lorraine. "Le web comme outil de diffusion des archives." Revue électronique suisse de science de l'information (RESSI), no. 07 (April 30, 2008): 11. https://doi.org/10.55790/journals/ressi.2008.e0704.

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Internet est aujourd’hui un outil de communication privilégié dans de nombreux domaines d’activité, dont les archives font partie. Dans cet article, je présenterai un état des lieux de la présence des archives sur Internet en commençant par une synthèse de la littérature sur le sujet suivie d’une analyse des sites internet d’archives actuels. Cet état des lieux permettra de contextualiser et d’appuyer la démarche de conception d’un site web d’archives que je présenterai en fin d’article. Ce guide méthodologique de diffusion constitue l’aboutissement d’un projet de recherche sur la diffusion de

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Major, Dan Thomas, and Michal Weitman. "Electrostatically Guided Dynamics—The Root of Fidelity in a Promiscuous Terpene Synthase?" Journal of the American Chemical Society 134, no. 47 (2012): 19454–62. http://dx.doi.org/10.1021/ja308295p.

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42

Bellaiche, N., and E. Azoulay. "Cone beam et troisième molaire mandibulaire incluse." Revue d'Orthopédie Dento-Faciale 53, no. 1 (2019): 21–34. http://dx.doi.org/10.1051/odf/2019004.

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Les patients, comme les chirurgiens-dentistes, attendent beaucoup de l’orthodontiste pour les guider dans la prédiction d’évolution des dents de sagesse (DDS). L’imagerie est un outil clé pour la prise de décision et l’analyse pré-opératoire. Cet article est une synthèse des découvertes fortuites radiologiques liées à la troisième molaire mandibulaire et montre l’intérêt du CBCT. La pathologie associée à la troisième molaire est plus souvent observée dans le CBCT que dans la panoramique. Plus de troisièmes molaires seraient enlevées si les résultats pathologiques étaient basés sur le CBCT.

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Horisberger, Denis, and Micheline Meylan. "Le guide des stations forestières du canton de Vaud: synthèse pour les praticiens | The guide to forest stations in canton Vaud: a summary for practioners." Schweizerische Zeitschrift fur Forstwesen 160, s1 (2009): s43—s53. http://dx.doi.org/10.3188/szf.2009.s0043.

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The guide to forest stations in canton Vaud is a collection of references and applications intended for forest practitioners. This computer-based instrument constantly incorporates new information. The guide is conceived on transparent bases that can be repeated and thus called in question. It offers a simplified process for determining vegetation groups and evaluating their productivity. It is completed by some suggestions for a choice of species adapted to the station which takes into account their suitability for any given station, climate changes and the present composition of forest stand

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Mabesoone, Mathijs F. J., Stefan Leopold-Messer, Hannah A. Minas, et al. "Evolution-guided engineering of trans -acyltransferase polyketide synthases." Science 383, no. 6689 (2024): 1312–17. http://dx.doi.org/10.1126/science.adj7621.

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Bacterial multimodular polyketide synthases (PKSs) are giant enzymes that generate a wide range of therapeutically important but synthetically challenging natural products. Diversification of polyketide structures can be achieved by engineering these enzymes. However, notwithstanding successes made with textbook cis -acyltransferase ( cis -AT) PKSs, tailoring such large assembly lines remains challenging. Unlike textbook PKSs, trans -AT PKSs feature an extraordinary diversity of PKS modules and commonly evolve to form hybrid PKSs. In this study, we analyzed amino acid coevolution to identify a

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Shimizu, T., Y. Nakanishi, Y. Nakagawa, et al. "Thymidylate Synthase Expression can Guide Treatment Selection for Advanced Non-Small Cell Lung Cancer Patients." Annals of Oncology 23 (September 2012): ix407. http://dx.doi.org/10.1016/s0923-7534(20)33835-7.

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Guerriero, Gea, Sylvain Legay, and Jean-Francois Hausman. "Alfalfa Cellulose Synthase Gene Expression under Abiotic Stress: A Hitchhiker’s Guide to RT-qPCR Normalization." PLoS ONE 9, no. 8 (2014): e103808. http://dx.doi.org/10.1371/journal.pone.0103808.

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Gould, Matthew K., Sam Dean, and Achim C. Schnaufer. "How to survive and thrive without mitochondrial DNA: A protozoan's guide to ATP synthase modification." Biochimica et Biophysica Acta (BBA) - Bioenergetics 1797 (July 2010): 32. http://dx.doi.org/10.1016/j.bbabio.2010.04.114.

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Morris, Francine, Ryan Vierling, Lauren Boucher, Jürgen Bosch, and Caren L. Freel Meyers. "DXP Synthase-Catalyzed CN Bond Formation: Nitroso Substrate Specificity Studies Guide Selective Inhibitor Design." ChemBioChem 14, no. 11 (2013): 1309–15. http://dx.doi.org/10.1002/cbic.201300187.

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Mank, Nicholas, Amy Arnette, Vince Klapper, Lesa Offermann, and Maksymilian Chruszcz. "Structure of dihydrodipicolinate synthase from the commensal bacteriumBacteroides thetaiotaomicronat 2.1 Å resolution." Acta Crystallographica Section F Structural Biology Communications 71, no. 4 (2015): 449–54. http://dx.doi.org/10.1107/s2053230x15004628.

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Dihydrodipicolinate synthase (DapA) catalyzes the first committed step of the diaminopimelate biosynthetic pathway of lysine. It has been shown to be an essential enzyme in many bacteria and has been the subject of research to generate novel antibiotics. However, this pathway is present in both pathogenic and commensal bacteria, and antibiotics targeting DapA may interfere with normal gut colonization.Bacteroides thetaiotaomicronis a Gram-negative commensal bacterium that makes up a large proportion of the normal microbiota of the human gut. The structure of DapA fromB. thetaiotaomicron(BtDapA

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Kim, Woojoo E., Katherine Charov, Mária Džunková, et al. "Synthase-Selective Exploration of a Tunicate Microbiome by Activity-Guided Single-Cell Genomics." ACS Chemical Biology 16, no. 5 (2021): 813–19. http://dx.doi.org/10.1021/acschembio.1c00157.

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