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1

Sharma, Parikshit S. y Pugazhendhi Vijayaraman. "Conduction System Pacing for Cardiac Resynchronisation". Arrhythmia & Electrophysiology Review 10, n.º 1 (12 de abril de 2021): 51–58. http://dx.doi.org/10.15420/aer.2020.45.

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Conduction system pacing (CSP) is a technique of pacing that involves implantation of permanent pacing leads along different sites of the cardiac conduction system and includes His bundle pacing and left bundle branch pacing. There is an emerging role for CSP to achieve cardiac resynchronisation in patients with heart failure with reduced ejection fraction and inter-ventricular dyssynchrony. In this article, the authors review these strategies for resynchronisation and the available data on the use of CSP in overcoming dyssynchrony.
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2

Domenichini, Giulia, Ihab Diab, Niall Campbell, Mehul Dhinoja, Ross Hunter, Simon Sporton, Mark Earley y Richard Schilling. "55 A Highly Effective Technique for Transseptal Endocardial Left Ventricular Lead Placement for Delivery of Cardiac Resynchronisation Therapy". Heart 101, Suppl 4 (junio de 2015): A30.2—A31. http://dx.doi.org/10.1136/heartjnl-2015-308066.55.

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3

Gabor, Sabine, Guenther Prenner, Andrae Wasler, Martin Schweiger, Karl Heinz Tscheliessnigg y Frejya Maria Smolle-Jüttner. "A simplified technique for implantation of left ventricular epicardial leads for biventricular resynchronisation using video-assisted thoracoscopy (VATS)". European Journal of Cardio-Thoracic Surgery 28, n.º 6 (diciembre de 2005): 797–800. http://dx.doi.org/10.1016/j.ejcts.2005.08.026.

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4

Shah, Ashok J., Meleze Hocini, Patrizio Pascale, Laurent Roten, Yuki Komatsu, Matthew Daly, Khaled Ramoul et al. "Body Surface Electrocardiographic Mapping for Non-invasive Identification of Arrhythmic Sources". Arrhythmia & Electrophysiology Review 2, n.º 1 (2013): 16. http://dx.doi.org/10.15420/aer.2013.2.1.16.

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The authors describe a novel three-dimensional, 252-lead electrocardiography (ECG) and computed tomography (CT)-based non-invasive cardiac imaging and mapping modality. This technique images potentials, electrograms and activation sequences (isochrones) on the epicardial surface of the heart. This tool has been investigated in the normal cardiac electrophysiology and various tachyarrhythmic, conduction and anomalous depo-repolarisation disorders. The clinical application of this system includes a wide range of electrical disorders like atrial arrhythmias (premature atrial beat, atrial tachycardia, atrial fibrillation), ventricular arrhythmias (premature ventricular beat, ventricular tachycardia) and ventricular pre-excitation (Wolff-Parkinson-White syndrome). In addition, the system has been used in exploring abnormalities of the His-Purkinje conduction like the bundle branch block and intraventricular conduction disturbance and thereby useful in electrically treating the associated heart failure (cardiac resynchronisation). It has a potential role in furthering our understanding of abnormalities of ventricular action potential (depolarisation [Brugada syndrome and repolarisation], long QT and early repolarisation syndromes) and in evaluating the impact of drugs on His-Purkinje conduction and cardiac action potential.
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5

Chousou, Panagiota A., Rahul K. Chattopadhyay, Gareth D. K. Matthews, Vassilios S. Vassiliou y Peter J. Pugh. "Location, Location, Location: A Pilot Study to Compare Electrical with Echocardiographic-Guided Targeting of Left Ventricular Lead Placement in Cardiac Resynchronisation Therapy". Diagnostics 14, n.º 3 (30 de enero de 2024): 299. http://dx.doi.org/10.3390/diagnostics14030299.

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Introduction: Cardiac resynchronisation therapy is ineffective in 30–40% of patients with heart failure with reduced ejection fraction. Targeting non-scarred myocardium by selecting the site of latest mechanical activation using echocardiography has been suggested to improve outcomes but at the cost of increased resource utilisation. The interval between the beginning of the QRS complex and the local LV lead electrogram (QLV) might represent an alternative electrical marker. Aims: To determine whether the site of latest myocardial electrical and mechanical activation are concordant. Methods: This was a single-centre, prospective pilot study, enrolling patients between March 2019 and June 2021. Patients underwent speckle-tracking echocardiography (STE) prior to CRT implantation. Intra-procedural QLV measurement and R-wave amplitude were performed in a blinded fashion at all accessible coronary sinus branches. Pearson’s correlation coefficient and Cohen’s Kappa coefficient were utilised for the comparison of electrical and echocardiographic parameters. Results: A total of 20 subjects had complete data sets. In 15, there was a concordance at the optimal site between the electrically targeted region and the mechanically targeted region; in four, the regions were adjacent (within one segment). There was discordance (≥2 segments away) in only one case between the two methods of targeting. There was a statistically significant increase in procedure time and fluoroscopy duration using the intraprocedural QLV strategy. There was no statistical correlation between the quantitative electrical and echocardiographic data. Conclusions: A QLV-guided approach to targeting LV lead placement appears to be a potential alternative to the established echocardiographic-guided technique. However, it is associated with prolonged fluoroscopy and overall procedure time.
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6

Waight, Michael, Abdula Elawady, Heather Gage, Morro Touray y Shaumik Adhya. "Day case complex devices: the state of the UK". Open Heart 6, n.º 1 (abril de 2019): e001023. http://dx.doi.org/10.1136/openhrt-2019-001023.

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ObjectiveComplex cardiac devices including implantable cardioverter defibrillator (ICD) and cardiac resynchronisation therapy (CRT) devices can safely be implanted as a day case procedure as opposed to overnight stay. We assess how common day case complex device therapy is and the cost implications of more widespread adoption across the UK.MethodsA freedom of information request was sent to all centres performing complex cardiac devices across the UK to assess the adoption of this technique. Cost implications were assessed using Department of Health National Schedule of Reference Costs 2016–2017.Results100 UK centres were surveyed, 80% replied. Eighty per cent of UK centres already implant complex cardiac devices as a day case to some extent. 64.06% of centres have a protocol for this. 12.82% of centres do <25% of complex devices as a day case. 15.38% do 25%–50% as day case. 17.95% do 50%–75% as day case and 33.33% do >75% as day case. There was no relationship between centre volume and the proportion of devices done as a day case as opposed to overnight stay. The cost saving of performing a complex device as a day case as opposed to overnight stay was £412 per ICD, £525 per CRT-pacemaker and £2169 per CRT-defibrillator.ConclusionsDay case complex devices are already widespread across the UK, however, there is scope for increase. An increase in proportion of day case devices could translate to £5 583 265 in savings annually for the National Health Service if all centres performed 75% of devices as a day case.
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7

Sidhu, Baldeep S., Justin Gould, Mark K. Elliott, Vishal Mehta, Steven Niederer y Christopher A. Rinaldi. "Leadless Left Ventricular Endocardial Pacing and Left Bundle Branch Area Pacing for Cardiac Resynchronisation Therapy". Arrhythmia & Electrophysiology Review 10, n.º 1 (12 de abril de 2021): 45–50. http://dx.doi.org/10.15420/aer.2020.46.

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Cardiac resynchronisation therapy is an important intervention to reduce mortality and morbidity, but even in carefully selected patients approximately 30% fail to improve. This has led to alternative pacing approaches to improve patient outcomes. Left ventricular (LV) endocardial pacing allows pacing at site-specific locations that enable the operator to avoid myocardial scar and target areas of latest activation. Left bundle branch area pacing (LBBAP) provides a more physiological activation pattern and may allow effective cardiac resynchronisation. This article discusses LV endocardial pacing in detail, including the indications, techniques and outcomes. It discusses LBBAP, its potential benefits over His bundle pacing and procedural outcomes. Finally, it concludes with the future role of endocardial pacing and LBBAP in heart failure patients.
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8

Lewis, Geoffrey F. y Michael R. Gold. "Developments in Cardiac Resynchronisation Therapy". Arrhythmia & Electrophysiology Review 04, n.º 2 (2015): 122. http://dx.doi.org/10.15420/aer.2015.04.02.122.

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Cardiac resynchronisation therapy (CRT) is an important therapy for patients with heart failure with a reduced ejection fraction and interventricular conduction delay. Large trials have established the role of CRT in reducing heart failure hospitalisations and improving symptoms, left ventricular (LV) function and mortality. Guidelines from major medical societies are consistent in support of CRT for patients with New York Health Association (NYHA) class II, III and ambulatory class IV heart failure, reduced LV ejection fraction and QRS prolongation, particularly left bundle branch block. The current challenge facing practitioners is to maximise the rate of patients who respond to CRT and the magnitude of that response. Current areas of interest for achieving these goals include tailoring patient selection, individualising LV lead placement and application of new technologies and techniques for CRT delivery.
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9

Tang, Haipeng, Shaojie Tang y Weihua Zhou. "A Review of Image-guided Approaches for Cardiac Resynchronisation Therapy". Arrhythmia & Electrophysiology Review 6, n.º 2 (2017): 69. http://dx.doi.org/10.15420/aer.2016.32.2.

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Cardiac resynchronisation therapy (CRT) is a standard treatment for patients with heart failure; however, the low response rate significantly reduces its cost-effectiveness. A favourable CRT response primarily depends on whether implanters can identify the optimal left ventricular (LV) lead position and accurately place the lead at the recommended site. Myocardial imaging techniques, including echocardiography, cardiac magnetic resonance imaging and nuclear imaging, have been used to assess LV myocardial viability and mechanical dyssynchrony, and deduce the optimal LV lead position. The optimal position, presented as a segment of the myocardial wall, is then overlaid with images of the coronary veins from fluoroscopy to aid navigation of the LV lead to the target venous site. Once validated by large clinical trials, these image-guided techniques for CRT lead placement may have an impact on current clinical practice.
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10

Tang, Haipeng, Shaojie Tang y Weihua Zhou. "A Review of Image-guided Approaches for Cardiac Resynchronisation Therapy". Arrhythmia & Electrophysiology Review 6, n.º 2 (2017): 69. http://dx.doi.org/10.15420/aer.2016:32:2.

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Cardiac resynchronisation therapy (CRT) is a standard treatment for patients with heart failure; however, the low response rate significantly reduces its cost-effectiveness. A favourable CRT response primarily depends on whether implanters can identify the optimal left ventricular (LV) lead position and accurately place the lead at the recommended site. Myocardial imaging techniques, including echocardiography, cardiac magnetic resonance imaging and nuclear imaging, have been used to assess LV myocardial viability and mechanical dyssynchrony, and deduce the optimal LV lead position. The optimal position, presented as a segment of the myocardial wall, is then overlaid with images of the coronary veins from fluoroscopy to aid navigation of the LV lead to the target venous site. Once validated by large clinical trials, these image-guided techniques for CRT lead placement may have an impact on current clinical practice.
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11

Iskenderov, Bakhram G., Tatiana V. Lokhina y Marina G. Ivanchukova. "Possibilities and safety of physiotherapy in patients with implanted cardiac devices". Russian Journal of Physiotherapy, Balneology and Rehabilitation 18, n.º 3 (8 de marzo de 2021): 183–90. http://dx.doi.org/10.17816/1681-3456-2019-18-3-183-190.

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Widespread implantation of cardiac devices, i.e. cardiac pacemakers, cardioverter-defibrillators and cardiac resynchronisation devices improved patients survival. It has resulted in increase in number of ageing patients with cardiac devices who need physiotherapeutic treatment due to accompanied comorbidities. Hence the study of the interaction between functions of cardiac devices and physiotherapeutic treatment techniques is particularly relevant. The use and safety of physiotherapeutic treatment techniques producing electromagnetic field which in turn eventually cause harm of the cardiac devices are being discussed in present review article. The possible adverse effects of such interaction are abrupt failure to stimulate or triggering of shock therapy with consequent arrhythmic events including cardiac arrest. The technical characteristics particularly associated with electromagnetic interference are discussed here in detail. The attention is also payed to analysis of possible causes and effects of electromagnetic interference and safety measures as well.
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12

van Hemel, N. M. y M. Scheffer. "Cardiac resynchronisation therapy in daily practice and loss of confidence in predictive techniques to response". Netherlands Heart Journal 17, n.º 1 (enero de 2009): 4–5. http://dx.doi.org/10.1007/bf03086206.

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13

Kleijn, Sebastiaan A., Mohamed FA Aly y Otto Kamp. "The Future of Echocardiographic Left Ventricular Quantification – Towards Automated Assessment of Global and Regional Function in Four Dimensions". European Cardiology Review 7, n.º 4 (2011): 241. http://dx.doi.org/10.15420/ecr.2011.7.4.241.

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Quantification of global and regional left ventricular (LV) function using echocardiography has significantly improved with evolving technology and development of more robust techniques. By building on the strengths and solving some of the limitations of techniques such as 2D speckle tracking imaging and 3D echocardiography, newly developed 3D speckle tracking offers a comprehensive quantitative evaluation of global and regional LV function, including assessment of dyssynchrony. Not only chamber indices such as LV volumes and ejection fraction, but also parameters directly assessing global and regional myocardial function such as strain and torsion can now be visualised and quantified in one fast analysis. Data on the validation and application of these parameters are quickly accumulating, demonstrating great promise for their clinical use – for example, for identification of regional wall motion abnormalities, assessment of dyssynchrony and prediction of response to cardiac resynchronisation therapy. In this regard, 3D speckle tracking echocardiography serves as a major stepping stone towards a robust fully automated assessment of global and regional LV function in the near future.
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14

Nesser, Hans Joachim. "Wall Motion Tracking and Activation Imaging – Latest Developments and Applications for Patients with Heart Failure". European Cardiology Review 8, n.º 1 (2012): 51. http://dx.doi.org/10.15420/ecr.2012.8.1.51.

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Wall motion tracking is a relatively new tool to define regional and global wall motion, ventricular volumes and ejection fraction. Speckle-tracking echocardiography (STE) allows the calculation of a variety of myocardial function indices – including longitudinal, radial, transverse and circumferential strain, strain rate, displacement, velocity and rotation (twist and torsion) – not only as a 2D application, but also in 3D. In patients with heart failure and cardiac dyssynchrony, there remains a lack of optimal management regarding decisions to implant a cardiac resynchronisation therapy device. Many decisions are made based on data from electrocardiography. Whereas conventional echocardiographic techniques are of limited value in defining mechanical dyssynchrony, newer developments, such as 2D and 3D speckle tracking, have been shown to have significant potential to define the latest site of mechanical activation. Recent 3D STE innovations, including activation imaging, 3D strain and area tracking, open new doors to the definition of segmental delay of mechanical deformation related to time. There is considerable optimism that 3D techniques will improve the present understanding and treatment of patients with cardiac dyssynchrony.
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15

Auricchio, Angelo, François Regoli, Giulio Conte y Maria Luce Caputo. "Key Lessons from the ELECTRa Registry in the Modern Era of Transvenous Lead Extraction". Arrhythmia & Electrophysiology Review 6, n.º 3 (2017): 111. http://dx.doi.org/10.15420/aer.2017.25.1.

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The implantation rate of cardiac electronic devices has grown over the past decades. The number of treated patients has increased in parallel with the complexity of the patient population treated, being older, frailer, having more complex devices (in particular, cardiac resynchronisation therapy) and presenting with a greater comorbidity burden. As a consequence, there is a rising number of related implanted system complications, including malfunction and infection. Thus, the demand for transvenous lead extraction (TLE) has also substantially increased. To identify the indication to TLE by various operators and centres, techniques used to perform TLE, and the safety and efficacy of the current clinical practice of TLE, a large prospective registry has been started in Europe – the European Lead Extraction Controlled (ELECTRa) Registry. The key findings of the ELECTRa Registry are discussed in the present review and placed in the context of previous knowledge. The ELECTRa Registry confirms that the TLE procedure is a safe and effective treatment, with an acceptable risk–benefit ratio that is comparable with other well-known cardiological invasive procedures. Of course, TLE is accompanied by potential life-threatening complications; the vast majority of these can be managed by an experienced multidisciplinary team. Multiple factors predict complications, including patient/lead profile, centre experience and procedure volumes, which may suggest caution when accepting a patient for TLE.
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16

Clutier-Seguin, J. "Le diagnostic anténatal : un long fleuve tranquille ? Réflexion sur l’évolution des pratiques au CHU de Montpellier". Périnatalité 12, n.º 2 (junio de 2020): 55–62. http://dx.doi.org/10.3166/rmp-2020-0088.

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Témoignage d’une pratique par une sage-femme débutant son exercice en même temps que le diagnostic anténatal (DAN), l’article décrit les étapes techniques et l’évolution permanente d’un cadre législatif rigoureux. L’hypermédicalisation s’est imposée de manière exponentielle en même temps que la nécessité d’affronter les émotions et les temporalités différentes entre équipes et couples. Les séquelles émotionnelles chez les femmes et les couples obligent à inventer un accompagnement relationnel adéquat. Il fallait avancer ensemble, trouver les bons mots, donner une nouvelle place aux femmes et aux conjoints, aider les professionnels pour qu’ils puissent faire face aux émotions violentes, améliorer les transmissions, recueillir des témoignages, inventer des modèles de prise en charge, enfin construire des formations adéquates. Une histoire collective s’est écrite au fil des progrès et se poursuit : la loi, les parents, les soignants. L’efficacité du travail en équipe, l’ouverture sur la pluridisciplinarité, la capacité d’adapter les pratiques au cas par cas, la richesse du travail en « indirect » avec les pédopsychiatres, la création de nouveaux outils de communication pour assurer la cohérence du suivi sont autant d’acquis significatifs. Le chemin du DAN demande aux soignants de rester vigilants et inventifs pour garder intacts les projets de vie des parents rencontrés. La place du père est devenue évidente et nécessaire en prévention des difficultés ultérieures. Une méthode récente de reprise des antécédents obstétricaux, alliant dossier médical et narration par la personne concernée, permet de remobiliser le traumatisme séquellaire par une resynchronisation des données concrètes et des traces mémorielles chez la femme.
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17

Kuznetsov, V. A., T. N. Yenina, P. V. Shebeko, A. Yu Rychkov, T. I. Petelina, N. N. Melnikov y T. O. Vinogradova. "Influence of cardiac resynchronisation therapy combined with other interventional methods on the neuro-immuno-humoral status of patients with ischemic cardiomyopathy". Patologiya krovoobrashcheniya i kardiokhirurgiya 18, n.º 4 (10 de octubre de 2015): 151. http://dx.doi.org/10.21688/1681-3472-2014-4-151-157.

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The purpose of this research was to study the influence of cardiac resynchronisation therapy (CRT) in combination with other interventional techniques used during one hospital stay on systemic inflammation and neurohumoral status in patients with ischemic cardiomyopathy (ICMP). The best response to CRT was estimated in 59 patients with ICMP (mean age 588.3 years, 92% males).The patients were divided into 2 groups: Group I patients (n=48) included those with 'pure' CRT, while Group II patients (n=11) underwent CRT, coronary stenting (CS), radiofrequency atrioventricular node ablation (RFA). All interventions were performed during one hospital stay. There were no significant differences in demographic characteristics between the groups. Mean follow-up was 6.0 [2.0; 16.0] months. Plasma levels of Nt-proBNP, interleukin (IL)-1, IL-6, IL-10, tumor necrosis factor-alpha (TNF-), C-reactive protein (CRP), urinary levels of epinephrine and norepinephrine (NE) were measured. The patients with a decrease in left ventricular end-systolic volume 15% were classified as responders. There were no significant differences in responders between the groups and was equal to 32 (67%) and 9 (82%) respectively. At baseline the plasma levels of IL-6 and CRP were higher in Group II as compared with Group I: 9.3 [4.6; 14.8] vs 3.3 [1.9; 5.2] pg/ml, respectively (p=0.004) and 8.0 [6.0; 10.2] vs 3.2 [1.5; 5.1] mg/ml respectively (p=0.065). At baseline the urinary NE level was lower in Group II as compared with Group I: 30.0 [17.6; 34.4] vs 58.0 [38.5; 74.6] nmol/ml respectively (p=0.023). During follow-up in Group I only Nt-proBNP level (p=0.015) tended to decrease. In Group II the levels of IL-6 (p=0.038), TNF- (p=0.024), CRP (p=0.031) decreased and NE level increased (p=0.038). Thus, the combination of CRT with other interventions is associated with a decrease in systemic inflammation and an impact on the neurohumoral status of patients with ICMP as compared with 'pure' CRT.
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18

Raine, D. T., G. A. Begg, J. Moore, E. C. Taylor, R. T. Buck, Shohreh Honarbakhsh, Wern Yew Ding et al. "POSTERS (1)59MULTIPOLAR CONTACT MAPPING GUIDED ABLATION OF TEMPORALLY STABLE HIGH FREQUENCY AND COMPLEX FRACTIONATED ATRIAL ELECTROGRAM SITES IN PATIENTS WITH PERSISTENT ATRIAL FIBRILLATION60INTRA-CARDIAC AND PERIPHERAL LEVELS OF BIOCHEMICAL MARKERS OF FIBROSES IN PATIENTS UNDERGOING CATHETER ABLATION FOR ATRIAL FIBRILATION61THE DON'T WAIT TO ANTICOAGULATE PROJECT (DWAC) BY THE WEST OF ENGLAND ACADEMIC HEALTH SCIENCE NETWORK (AHSN) OPTIMISES STROKE PREVENTION FOR PATIENTS WITH ATRIAL FIBRILLATION (AF) WITHIN PRIMARY CARE IN LINE WITH NICE CG180 IN THE WEST OF ENGLAND62ILLNESS AND TREATMENT REPRESENTATIONS, COPING AND DISTRESS: VICIOUS CYCLES OF EVERYDAY EXPERIENCES IN PATIENTS WITH PERSISTENT ATRIAL FIBRILLATION63THE NEEDS OF THE ADOLESCENT LIVING WITH AN INHERITED CARDIAC CONDITION: THE PATIENTS' PERSPECTIVE64SAFETY AND EFFICACY OF PARAMEDIC TREATMENT OF REGULAR SUPRAVENTRICULAR TACHYCARDIA (PARA-SVT)65NATURAL PROGRESSION OF QRS DURATION FOLLOWING IMPLATABLE CARDIOVERTER DEFIBRILLATORS (ICD) - IMPLANTATION66COMPARISON OF EFFICACY OF VOLTAGE DIRECTED CAVOTRICUSPID ISTHMUS ABLATION USING MINI VS CONVENTIONAL ELETRODES67CRYOBALLOON ABLATION (CRYO) FOR ATRIAL FIBRILLATION (AF) CANNOT BE GUIDED BY TEMPERATURE END-POINTS ALONE68MODERATOR BAND ECTOPY UNMASKED BY ADENOSINE AS A CAUSE OF ECTOPIC TRIGGERED IDIOPATHIC VF69EARLY CLINICAL EXPERIENCE WITH TARGETED SITE SELECTION FOR THE WiCS-LV ELECTRODE FOR CRT70DOES VECTOR MAPPING PRIOR TO IMPLANTABLE LOOP RECORDER INSERTION IMPROVE THE DETECTION OF ARRHYTHMIA?71THE ROLE OF SPECKLE TRACKING STRAIN IMAGING IN ASSESSING LEFT VENTRICULAR RESPONSE TO CARDIAC RESYNCHRONISATION THERAPY IN RESPONDERS AND NON-RESPONDERS72EVALUATING PATIENTS' EXPERIENCE AND SATISFACTION OF THE ATRIAL FIBRILLATION ABLATION PROCEDURE: A RETROSPECTIVE ANALYSIS73TROUBLESHOOTING LV LEAD IMPLANTATION - NOVEL “UNIRAIL TECHNIQUE”74SUBCLINICAL ATHEROSCELEROSIS AND COGNITIVE IMPAIRMENT75EFFECT OF LOZARTANE ON DEVELOPMENT OF THE ELECTRICAL INSTABILITY OF THE MYOCARDIUM76THE INTERPLAY BETWEEN BODY COMPOSITION AND LEFT VENTRICULAR REMODELLING IN CARDIAC RESYNCHRONISATION THERAPY77FAMILY SCREENING IN IDIOPATHIC VENTRICULAR FIBRILLATION78MANAGEMENT OF ATRIAL FIBRILLATION IN A LARGE TEACHING HOSPITAL79THE EFFECT OF LEFT VENTRICULAR LEAD POSITION ON SURVIVAL IN PATIENTS WITH BINVENTRICULAR PACEMAKRS/DEFIBRILLATORS80ACUTE DEVICE IMPLANT-RELATED COMPLICATIONS DO NOT INCREASE LATE MORTALITY81ABORTED CARIDAC ARREST AS THE SENTINEL PRESENTATION IN A COHORT OF PATIENTS WITH THE CONCEALED BRUGADA PHENOTYPE82POST-CARDIAC DEVICE IMPLANTATION MOBILISATION ADVICE: A NATIONAL SURVEY83DO RISK SCORES DEVELOPED TO PROTECT ONE-YEAR MORTALITY ACTUALLY HELP IN ACCURATELY SELECTING PATIENTS RECEIVING PRIMARY PREVENTION ICD?84ATRIAL TACHYCARDIA ARISING FROM THE NON-CORONARY AORTIC CUSP85THE EFFECT OF DIFFERENT ATRIAL FIBRILLATION ABLATION STRATEGIES ON SURFACE ECG P WAVE DURATION86PRESCRIBING DRONEDARONE: HOW IS IT DONE ACROSS THE UK AND IS IT SAFE?87A CASE OF WIDE COMPLEX TACHYCARDIA88TRANSITION TO DEDICATED DAY CASE DEVICES - SAFETY AND EFFICACY IN A LARGE VOLUME CENTRE89SEQUENTIAL REGIONAL DOMINANT FREQUENCY MAPPING DURING ATRIAL FIBRILLATION: A NOVEL TEQUNIQUE90ELECTIVE CARDIOVERSION ENERGY PROTOCOLS: A RETROSPECTIVE COMPARISON OF ESCALATION STRATEGIES91THE INCIDENCE OF CLINCALLY RELEVANT HAEMATOMAS WITH PERIOPERATIVE USE OF NEWER P2Y12 INHIBITORS AND INTERRUPTED NOAC THERAPY IN CARDIAC IMPLANTABLE ELECTRONIC DEVICE INSERTION92AN AUDIT OF THE OUTCOMES FOR CHEMICAL AND DIRECT CURRENT CARDIOVERSION FOR ATRIAL FIBRILLATION AT OUR DGH OVER A 3 YEAR DURATION93REAL LIFE ACUTE MANAGEMET OF HAEMODYNAMICALLY TOLERATED MONOMORPHIC VENTRICULAR TACHYCARDIA. ARE WE MAKING EVIDENCE BASED ON DECISIONS?94A SERVICE EVALUATION TO ASSESS THE EFFICACY AND SAFETY OF NOVEL ORAL ANTICOAGULANTS VERSUS WARFARIN FOR ELECTIVE CARDIVERSION IN PATIENTS WITH NON VALVULAR AF IN A NURSE LED CARDIOVERSION SERVICE95PICK UP RATE OF IMPLANTED LOOP RECORDER AT A DISTRICT HOSPITAL". Europace 18, suppl 2 (octubre de 2016): ii24—ii35. http://dx.doi.org/10.1093/europace/euw273.

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Rademakers, L. M., J. L. P. M. van den Broek y F. A. Bracke. "Left bundle branch pacing as an alternative to biventricular pacing for cardiac resynchronisation therapy". Netherlands Heart Journal, 3 de agosto de 2022. http://dx.doi.org/10.1007/s12471-022-01712-9.

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Abstract Background Left bundle branch pacing (LBBP) is a novel physiological pacing technique which may serve as an alternative to biventricular pacing (BVP) for the delivery of cardiac resynchronisation therapy (CRT). This study assessed the feasibility and outcomes of LBBP in comparison to BVP. Methods LBBP was attempted in 40 consecutive patients as the first-line method for delivering CRT. To evaluate LBBP versus BVP, 40 patients with identical inclusion criteria who received BVP were compared with the LBBP group. Acute success rate, complications, functional and echocardiographic outcomes as well as hospitalisation for heart failure and all-cause mortality 6 months after implantation were evaluated. Results LBBP was successfully performed in 31 (78%) patients and resulted in significant QRS narrowing (from 166 ± 16 to 123 ± 18 ms, p < 0.001), improvement in left ventricular ejection fraction (LVEF; from 28 ± 8 to 43 ± 12%, p < 0.001) and New York Heart Association functional class (from 2.8 ± 0.5 to 1.6 ± 0.6, p < 0.001) at 6 months. No LBBP-related complications occurred. Compared to BVP, LBBP resulted in a greater reduction in QRS duration (44 ± 17 vs 15 ± 26 ms, p < 0.001) with comparable absolute improvement in LVEF (15.2 ± 11.7 vs 9.6 ± 12.1%, p = 0.088). Hospitalisation for heart failure and all-cause mortality were similar in the two groups. Conclusions LBBP is feasible and was safe in 78% of patients with favourable electrical resynchronisation and functional improvement and may serve as an alternative to BVP.
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Rademakers, L. M., J. L. P. M. van den Broek, M. Op ’t Hof y F. A. Bracke. "Initial experience, feasibility and safety of permanent left bundle branch pacing: results from a prospective single-centre study". Netherlands Heart Journal, 26 de noviembre de 2021. http://dx.doi.org/10.1007/s12471-021-01648-6.

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Abstract Background Left bundle branch (LBB) pacing is a novel pacing technique which may serve as an alternative to both right ventricular pacing for symptomatic bradycardia and cardiac resynchronisation therapy (CRT). A substantial amount of data is reported by relatively few, highly experienced centres. This study describes the first experience of LBB pacing in a high-volume device centre. Methods Success rates (i.e. the ability to achieve LBB pacing), electrophysiological parameters and complications at implant and up to 6 months of follow-up were prospectively assessed in 100 consecutive patients referred for various pacing indications. Results The mean age was 71 ± 11 years and 65% were male. Primary pacing indication was atrioventricular (AV) block in 40%, CRT in 42%, and sinus node dysfunction or refractory atrial fibrillation prior to AV node ablation in 9% each. Baseline left ventricular ejection fraction was < 50% in 57% of patients, mean baseline QRS duration 145 ± 34 ms. Overall LBB pacing was successful in 83 of 100 (83%) patients but tended to be lower in patients with CRT pacing indication (69%, p = ns). Mean left ventricular activation time (LVAT) during LBB pacing was 81 ms and paced QRS duration was 120 ± 19 ms. LBB capture threshold and R‑wave sense at implant was 0.74 ± 0.4 mV at 0.4 ms and 11.9 ± 5.9 V and remained stable at 6‑month follow-up. No complications occurred during implant or follow-up. Conclusion LBB pacing for bradycardia pacing and resynchronisation therapy can be easily adopted by experienced implanters, with favourable success rates and safety profile.
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21

Wijesuriya, Nadeev, Mark K. Elliott, Vishal Mehta, Baldeep S. Sidhu, Marina Strocchi, Jonathan M. Behar, Steven Niederer y Christopher A. Rinaldi. "Leadless Left Bundle Branch Area Pacing in Cardiac Resynchronisation Therapy: Advances, Challenges and Future Directions". Frontiers in Physiology 13 (6 de junio de 2022). http://dx.doi.org/10.3389/fphys.2022.898866.

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Leadless left bundle branch area pacing (LBBAP) represents the merger of two rapidly progressing areas in the field of cardiac resynchronisation therapy (CRT). It combines the attractive concepts of pacing the native conduction system to allow more physiological activation of the myocardium than conventional biventricular pacing, with the potential added benefits of avoiding long-term complications associated with transvenous leads via leadless left ventricular endocardial pacing. This perspective article will first review the evidence for the efficacy of leadless pacing in CRT. We then summarise the procedural steps and pilot data for leadless LBBAP, followed by a discussion of the safety and efficacy of this novel technique. Finally, we will examine how further mechanistic evidence may shed light to which patients may benefit most from leadless LBBAP, and how improvements in current experience and technology could promote widespread uptake and expand current clinical indications.
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22

Wijesuriya, Nadeev, Mark K. Elliott, Vishal Mehta, Baldeep S. Sidhu, Marina Strocchi, Jonathan M. Behar, Steven Niederer y Christopher A. Rinaldi. "Leadless Left Bundle Branch Area Pacing in Cardiac Resynchronisation Therapy: Advances, Challenges and Future Directions". Frontiers in Physiology 13 (6 de junio de 2022). http://dx.doi.org/10.3389/fphys.2022.898866.

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Leadless left bundle branch area pacing (LBBAP) represents the merger of two rapidly progressing areas in the field of cardiac resynchronisation therapy (CRT). It combines the attractive concepts of pacing the native conduction system to allow more physiological activation of the myocardium than conventional biventricular pacing, with the potential added benefits of avoiding long-term complications associated with transvenous leads via leadless left ventricular endocardial pacing. This perspective article will first review the evidence for the efficacy of leadless pacing in CRT. We then summarise the procedural steps and pilot data for leadless LBBAP, followed by a discussion of the safety and efficacy of this novel technique. Finally, we will examine how further mechanistic evidence may shed light to which patients may benefit most from leadless LBBAP, and how improvements in current experience and technology could promote widespread uptake and expand current clinical indications.
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23

Kutarski, A., W. Jachec, P. Stefanczyk, P. Dabrowski, A. Glowniak, D. Nowosielecka y L. Tulecki. "Extraction of old His bundle pacing leads and coronary sinus leads - an analysis of 3897 lead extraction procedures including 27 His and 253 coronary sinus lead removals". European Heart Journal 45, Supplement_1 (octubre de 2024). http://dx.doi.org/10.1093/eurheartj/ehae666.743.

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Abstract Background The lumen-less the Medtronic 3830 lead is most popular for His bundle pacing (HBP) and experience with such lead extraction are very limited especially for leads older than 4 years. Methods Analysis of 3898 transvenous lead extraction (TLE) procedures (including 27 HBP and 253 LVP lead extraction) was performed. Results The HBP was used usually in the CRT-D system (72.4%) and EF and NYHA class were better than patients with LVP extracted leads. Age of extracted HBP or LVP lead did not differ significantly (54.5 vs 50.2 months). Extraction of "old" HBP leads extraction was longer than in case of "young HBP leads (8,6 and 3.8 min). Mechanical dilatation was necessary in 63 and 100% extracted HBP leads. Unexpected procedure difficulties appeared (14,3%) and utility of second line / advanced tools had been utilised (28,6%) only when "old" HBP lead were extracted. Difficulties in extracting HBP leads were comparable to those encountered in the extraction of LVP leads of similar age. There was no extracted 3830 extracted lead break and no major complication, necessity of rescue cardiac surgery and procedure related death when HBP and LVP leads were extracted. The length of the FU period for those still alive patients was shorter for patients with removed leads for HBP as this technique was introduced significantly later than LVP. However, the 1-month mortality rate of patients with LVP lead removed is higher than in the HBP and control groups. Conclusions 1. HBP most frequently is utilised in the CRT-D system for resynchronisation of failing heart (72.4%) 2. Extraction of HBP leads is performed most frequently due to non-infective indications (59,3%) and most often because of lead dysfunction (33,3%). 3. Extraction of "old" (&gt;40 mth) HBP leads is twice longer than younger ones (3.8 and 8,6 min) and mechanical dilatation is necessary frequently. 4. Extraction of "old" (&gt;40 mth) HBP leads is more difficult than younger ones due to appearance unexpected procedure difficulties (14,3%) and necessity utility of second line / advanced tools (28,6%) but it does not entail the risk of major complications and procedure related death. 5. Difficulties in extracting HBP leads comparable to those encountered in the extraction of LVP leads of similar age. 6. Survival after HBP and LVP lead extraction was comparable, but shorter than after removal of other leads.
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24

"Resynchronisation therapy: left ventricular implantations and new approaches, new stimulation techniques". EP Europace 7, s1 (2005): 55–56. http://dx.doi.org/10.1093/europace/7.s1.55-b.

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"Resynchronisation therapy: left ventricular implantations and new approaches, new stimulation techniques". EP Europace 7, s1 (2005): 56. http://dx.doi.org/10.1093/europace/7.s1.56.

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"Resynchronisation therapy: left ventricular implantations and new approaches, new stimulation techniques". EP Europace 7, s1 (2005): 57. http://dx.doi.org/10.1093/europace/7.s1.57.

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"Resynchronisation therapy: left ventricular implantations and new approaches, new stimulation techniques". EP Europace 7, s1 (2005): 57. http://dx.doi.org/10.1093/europace/7.s1.57-a.

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28

Wayne, Stephanie Lauren y Adam David Zimmet. "Surgical management of heart failure". Current Cardiology Reviews 17 (14 de abril de 2021). http://dx.doi.org/10.2174/1573403x17666210414094452.

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: Optimal management of heart failure is collaborative, with involvement of specialist heart failure physicians, nurses, interventionalists and surgeons. In addition to medical optimisation and cardiac resynchronisation therapy, surgery plays a valuable role in many patients. We herein detail the evidence behind and role for surgical intervention in functional mitral regurgitation, coronary revascularisation in ischaemic cardiomyopathy, and surgical ventricular reconstruction. Additionally, we describe techniques of temporary and durable mechanical circulatory support, with their relative advantages and disadvantages and applications. Finally, we describe the history and nomenclature around heart transplant, its indications, techniques, present-day outcomes, complications, and new developments in the field.
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29

"Different techniques to assess long-term results of cardiac resynchronisation therapy and beyond". EP Europace 7, s1 (2005): 90. http://dx.doi.org/10.1093/europace/7.s1.90-a.

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"Different techniques to assess long-term results of cardiac resynchronisation therapy and beyond". EP Europace 7, s1 (2005): 90–91. http://dx.doi.org/10.1093/europace/7.s1.90-b.

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"Different techniques to assess long-term results of cardiac resynchronisation therapy and beyond". EP Europace 7, s1 (2005): 91. http://dx.doi.org/10.1093/europace/7.s1.91.

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"Different techniques to assess long-term results of cardiac resynchronisation therapy and beyond". EP Europace 7, s1 (2005): 92. http://dx.doi.org/10.1093/europace/7.s1.92.

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"Different techniques to assess long-term results of cardiac resynchronisation therapy and beyond". EP Europace 7, s1 (2005): 93. http://dx.doi.org/10.1093/europace/7.s1.93.

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34

Ponnusamy, Shunmuga Sundaram y Pugazhendhi Vijayaraman. "How to Implant His Bundle and Left Bundle Pacing Leads: Tips and Pearls". Cardiac Failure Review 7 (6 de agosto de 2021). http://dx.doi.org/10.15420/cfr.2021.04.

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Cardiac pacing is the treatment of choice for the management of patients with bradycardia. Although right ventricular apical pacing is the standard therapy, it is associated with an increased risk of pacing-induced cardiomyopathy and heart failure. Physiological pacing using His bundle pacing and left bundle branch pacing has recently evolved as the preferred alternative pacing option. Both His bundle pacing and left bundle branch pacing have also demonstrated significant efficacy in correcting left bundle branch block and achieving cardiac resynchronisation therapy. In this article, we review the implantation tools and techniques to perform conduction system pacing.
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35

Papangelopoulou, K., M. Orlowska, L. Wouters, J. Duchenne, G. Voros, J. Ector y J. D'hooge. "High frame rate speckle tracking echocardiography for the mapping of cardiac mechanical activation sequence". European Heart Journal - Cardiovascular Imaging 24, Supplement_1 (junio de 2023). http://dx.doi.org/10.1093/ehjci/jead119.199.

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Abstract Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): KU Leuven. Background Cardiac arrhythmias are a leading cause of worldwide morbidity and mortality, with catheter ablation being an effective treatment. Current clinical practice includes performing an electrophysiological study in order to detect the focal source or the re-entrant circuit of the arrhythmia, i.e. the ablation target. This technique is invasive, with increased patient related risk and variable success rate. Conversely, echocardiography could be used to determine the correct ablation target. Indeed, high frame rate (HFR) ultrasound provides an adequately high temporal resolution, has proven helpful in detecting the onset of myocardial deformation and could be used for accurate localization of the arrhythmia sources. Purpose To test whether HFR speckle tracking echocardiography (STE) can be employed to construct cardiac mechanical activation maps. Methods 16 healthy volunteers (age: 30±6y; 69% males) and 11 heart failure patients treated with cardiac resynchronisation therapy (CRT) (age: 69±10y; 73% males) were included. All participants were scanned with a research high frame rate ultrasound scanner (frame rate: 848±101fps) and apical 4-, 2- and 3-chamber views were acquired. Patients were scanned with CRT on and after turning the device off, in order to allow native ventricular conduction. All patients had a left bundle branch block (LBBB) pattern of intrinsic activation on the surface ECG. For each apical view, a manually placed contour was tracked during the cardiac cycle by a custom-made 2D HFR STE algorithm; the contours were divided in a standard 16 segment model and segmental strain rate (SR) curves were computed and used to measure the temporal distance between electrical and mechanical activation (i.e. distance between the beginning of QRS and the first zero crossing in the SR curve representing the onset of segmental shortening). Finally, an activation map for each subject was created by placing the extracted timings in the middle of the corresponding segment of a bull’s-eye plot and interpolating values between them. Results Tracking was feasible in 96% of the segments; extracted curves showed a physiological pattern (Fig. 1A). For the healthy participants, mechanical activation started from the mid-anteroseptal (69%) or mid-inferoseptal (31%) segment at 22±5ms, spreading to the basal posterolateral segment at 50±8ms from the start of QRS, in all but two cases, where activation ended in the basal inferoseptal and basal inferior segment respectively (Fig. 1B). During CRT off, the septal wall was activated 31±9ms and the lateral wall 73±20ms after the beginning of QRS (p&lt;0.01) (Fig. 1C), whereas during CRT on, the septal wall was activated 40±11ms and the lateral wall 37±7ms after the beginning of QRS (p = 0.3) (Fig. 1D). Conclusion Our findings comply with left ventricular activation as described in the literature and show that HFR STE could be a useful tool in defining the ablation target for arrhythmia treatment.
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36

Papangelopoulou, K., M. Orlowska, L. Wouters, G. Voros, J. Ector y J. D'hooge. "High frame rate speckle tracking echocardiography to visualize the mechanical activation sequence of the left ventricle". European Heart Journal 44, Supplement_2 (noviembre de 2023). http://dx.doi.org/10.1093/eurheartj/ehad655.100.

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Abstract Background Cardiac arrhythmias are a known cause of morbidity and mortality, with catheter ablation being an effective treatment. In order to detect the focal source or the re-entrant circuit of the arrhythmia, i.e. the ablation target, current practice includes performing an electrophysiological study. This technique is invasive, with increased patient related risk and variable success rate. Conversely, echocardiography could be used to determine the correct ablation target. High frame rate (HFR) ultrasound has a temporal resolution adequately high to detect the onset of myocardial deformation and could assist the accurate localisation of the arrhythmia source. Purpose To test whether HFR speckle tracking echocardiography (STE) can be used to create cardiac mechanical activation maps. Methods 18 healthy volunteers (HV) (age 30±6y; 69 %males) and 12 heart failure patients treated with cardiac resynchronisation therapy (CRT) (age 69±10y; 75 %males) were included. All participants were scanned with a research HFR ultrasound scanner (∼849fps) and the 3 standard apical views were acquired. Patients were scanned with CRT on and after turning CRT off, in order to allow intrinsic ventricular conduction. Data from one CRT patient were acquired by temporarily altering the pacing pole of the CRT LV lead. All patients had a left bundle branch block (LBBB) pattern of native activation on the surface ECG. For each view, a manually placed contour was tracked during the cardiac cycle by a custom-made 2D HFR STE algorithm; the contours were divided in a standard 16 segment model and segmental strain rate (SR) curves were computed and used to measure the temporal distance between electrical and mechanical activation (i.e. distance between the beginning of QRS and the first positive to negative zero crossing in the SR curve). Finally, an activation map for each subject was created by placing the extracted timings in the middle of the corresponding segment of a bull’s-eye plot and interpolating values between them. Results Tracking was feasible in 94% of the segments; SR curves showed a physiological pattern (Fig. 1A). For the HV, mechanical activation started from mid anteroseptal (72%) or mid inferoseptal (28%) segment at 23±5ms, spreading to basal posterolateral segment at 49±8ms from the start of QRS, in all but one case, where activation ended at basal inferoseptal segment (Fig. 1B). During CRT off, septal wall was activated 31±9ms and lateral wall 74±20ms after the beginning of QRS (p&lt;0.01) (Fig. 1C), whereas during CRT on, septal wall was activated 41±11ms and lateral wall 38±7ms after the beginning of QRS (p=0.3) (Fig. 1D). Changing the pacing pole of the LV lead in one CRT patient also changed the start of mechanical activation in the lateral wall (Fig. 2). Conclusion Our findings comply with left ventricular activation as described in the literature and show that HFR STE could be a useful tool in defining the ablation target for arrhythmia treatment.
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McCormack, Cameron, Bryan Wai, Tracey Muir, Michelle Ord, Nagesh Anavekar, Leighton G. Kearney y Piyush M. Srivastava. "Abstract 2815: Validation of Rapid Automated Tissue Synchronisation Imaging Techniques for Assessment of Cardiac Dyssynchrony in both Sinus and Non-Sinus Rhythm". Circulation 116, suppl_16 (16 de octubre de 2007). http://dx.doi.org/10.1161/circ.116.suppl_16.ii_626-a.

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Background: Intraventricular dyssynchrony predicts left ventricle remodelling and clinical response following cardiac resynchronisation therapy. Currently, no consensus exists as to the most appropriate methodology for assessing dyssynchrony. Tissue Velocity Imaging (TVI) based septal to lateral delay (SLD) >65ms (Bax et al) and 12 segment dyssynchrony index (DI) (Yu et al) are most commonly used. These methods are time consuming and involve multiple manual calculations. Automated dyssynchrony assessment with Tissue Synchronisation Imaging (TSI) may provide a more rapid estimation of dyssynchrony. Aims: To assess the validity of automated TSI (TSI auto) based dyssynchrony measures in comparison to established TVI techniques. Methods: We randomly selected echocardiograms of 51 subjects (Sinus rhythm (SR) n=35, AF/paced n=16) from our heart failure service and compared TSI auto to conventional TVI methods (SLD and DI). For TSI auto, 6 basal and 6 mid segments were defined and dyssynchrony parameters calculated with the Echopac 6 software. Results: The mean age of the group was 66±11 years, 86% were male. The majority had ischaemic aetiology (69%) and the mean LVEF was 35.2±1.3%. Mean QRS duration was 138±6ms (LBBB 54%) and 69% were in SR. Bland-Altman analysis of TVI and TSI auto DI showed excellent agreement (Limits of agreement (LOA): -8.7 to 15.9, p=0.16) (Figure ). Agreement between SLD techniques was acceptable (LOA: -169 to 137 p=0.9). ROC curves were constructed for TSI auto (AUC SR 0.9, non-SR 0.917). Conclusions: Automated TSI provides an accurate and efficient means of measurement of intraventricular dyssynchrony in both sinus and non sinus rhythm.
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38

Chousou, P., R. Chattopadhyay, K. Sanders, V. Carpenter, J. Hayes, V. Vassiliou y P. Pugh. "Optimal left ventricular lead positioning during cardiac resynchronisation therapy; a comparison of 2 methods". European Heart Journal 42, Supplement_1 (1 de octubre de 2021). http://dx.doi.org/10.1093/eurheartj/ehab724.0707.

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Abstract Background/Introduction Superior response to CRT and improved clinical outcomes can be achieved when placing the left ventricular (LV) lead at the site of latest mechanical activation and avoiding regions of scar during cardiac resynchronisation therapy (CRT). The site of latest mechanical activation can be identified using speckle-tracking echocardiography, whilst the area of latest electrical activation can be assessed by measuring QLV, the time from the initial deflection of the surface QRS complex to sensing at the LV lead electrode. It remains unclear if the two techniques are interchangeable and whether the site of latest mechanical activation is related to the site of latest electrical activation, or sensed electrical signals correspond to sites of scar. Purpose To determine whether electrical targeting of LV lead position corresponds to echo-guided mechanical targeting and whether myocardial electrogram signals can predict areas of myocardial scar Methods This was a pilot study of patients receiving CRT, in sinus rhythm with severe LV impairment (ejection fraction ≤35%) and left bundle branch block (LBBB) with QRS ≥130ms. Ethics approval was obtained, and written consent was sought. Participants underwent echocardiographic speckle-tracking 2-dimensional radial strain imaging to identify amplitude and time to peak contraction of posterior, posterolateral, lateral, anterolateral and anterior segments. During CRT implant, the sensed R wave and QLV were measured at the respective branch of the coronary sinus, where the anatomy permitted. The site of latest mechanical was compared to the site of latest electrical activation and classified as concordant (same site), adjacent (within 1 segment), or remote (2 segments away). The strain amplitude was compared to the sensed R wave and time to mechanical activation with QLV. Results Seventeen patients (13 male) were studied, mean age 74.2 (SD 8.7). Mean QRS was 161 ms (SD 18), mean PR 186 ms (SD 37). A modest and significant positive correlation was found between the site of latest mechanical and latest electrical activation (Pearson r=0.66, p 0.004). The site of latest electrical activation was concordant with latest mechanical activation in 13 patients (76.5%), adjacent in 4 patients (23.5%) and remote in none. There was no apparent association between sensed R wave and strain amplitude (Pearson r=0.2, p=0.12) or between QLV and time to mechanical activation (Pearson r=0.1, p=0.5). Conclusion A significant positive correlation was found between the site of latest mechanical and latest electrical activation in patients undergoing CRT implant. Electrical targeting might be a suitable alternative to mechanical targeting particularly when imaging is not available, however, does not appear to discriminate scar. Future larger studies are needed to confirm our findings and determine whether QLV can be used as an alternative method for targeting LV lead placement. Funding Acknowledgement Type of funding sources: None.
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39

Theuns, D. A., T. E. Verstraelen, A. C. J. van der Lingen, P. P. Delnoy, C. P. Allaart, L. van Erven, A. H. Maass et al. "Implantable defibrillator therapy and mortality in patients with non-ischaemic dilated cardiomyopathy". Netherlands Heart Journal, 6 de septiembre de 2022. http://dx.doi.org/10.1007/s12471-022-01718-3.

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Abstract Background Primary prophylactic implantable cardioverter-defibrillators (ICDs) in patients with non-ischaemic cardiomyopathy (NICMP) remains controversial. This study sought to assess the benefit of ICD therapy with or without cardiac resynchronisation therapy (CRT) in patients with NICMP. In addition, data were compared with real-world clinical data to perform a risk/benefit analysis. Methods Relevant randomised clinical trials (RCTs) published in meta-analyses since DANISH, and in PubMed, EMBASE and Cochrane databases from 2016 to 2020 were identified. The benefit of ICD therapy stratified by CRT use was assessed using random effects meta-analysis techniques. Results Six RCTs were included in the meta-analysis. Among patients without CRT, ICD use was associated with a 24% reduction in mortality (hazard ratio [HR]: 0.76; 95% confidence interval [CI]: 0.62–0.93; P = 0.008). In contrast, among patients with CRT, a CRT-defibrillator was not associated with reduced mortality (HR: 0.74, 95% CI 0.47–1.16; P = 0.19). For ICD therapy without CRT, absolute risk reduction at 3‑years follow-up was 3.7% yielding a number needed to treat of 27. Conclusion ICD use significantly improved survival among patients with NICMP who are not eligible for CRT. Considering CRT, the addition of defibrillator therapy was not significantly associated with mortality benefit compared with CRT pacemaker.
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Cabrera Borrego, E., M. Molina Lerma, R. Rivera Lopez, E. Constan De La Revilla y M. Alvarez Lopez. "Automatic subcutaneous defibrillator screening in patients with intracardiac devices: comparative study depending on the point of pacing". Europace 25, Supplement_1 (24 de mayo de 2023). http://dx.doi.org/10.1093/europace/euad122.420.

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Abstract Funding Acknowledgements Type of funding sources: None. Background/Introduction Subcutaneous defibrillator (S-ICD) has been shown to be effective in the prevention of sudden cardiac death with the advantage of avoiding intravascular access. Although it should not be indicated when pacing indications exists, the need for pacing may arise in the course of underlying heart disease. Before implantation, it is necessary to screen the surface electrocardiogram (ECG) to avoid inappropriate shocks due to overdetection. Published studies so far show a drastic reduction in the percentage of patients eligible for screening with conventional pacing techniques (right ventricular apex, right ventricular outflow tract or resynchronisation with coronary sinus pacing). Purpose The change in screening signal produced by cardiac pacing during is unknown. So far, no studies have been published comparing the outcome of S-ICD screening between different pacing sites, including conduction system pacing (CSP, his and left bundle branch pacing). Our aim is to analyse the success rate of screening and its predictors in patients with cardiac pacing according to the pacing point. Methods A total of 102 patients were screened for S-ICD and divided into 5 groups according to pacing type: His bundle pacing (HBP), left bundle pacing (LBP), right ventricular apex (RVA), right ventricular outflow tract (RVOT) and biventricular cardiac resynchronisation (CRT). There were no significant differences in any variable between the HBP and LBP group, so they were unified as the CSP group. We used a control group of 10 healthy patients with no implantable devices or ECG abnormalities. All patients underwent automatic screening with paced rhythm using the automatic algorithm (Boston Scientific). We considered a suitable screening when at least one vector (primary, secondary or alternative) was positive in both decubitus and standing position, in left or right parasternal position. Results Baseline characteristics by group are summarised in table1. Paced QRS width was lower in the CSP group (135 [120-160] vs 120 [106-120] p=0,001). All healthy controls passed the screening (100%). 39 (97.5%) CSP patients passed the screening, compared to 15 (71.4%) CRT, 14 (70%) RVOT and 4 (19%) RVA. The differences were statistically significant, p &lt; 0.001 (image 1 A & B). In multivariate analysis, only pacing type was shown to be a predictor of positive screening (p 0.001), independent of paced QRS width. Conclusions In our experience, the probability of obtaining a positive screening of the S-ICD is higher with conduction system stimulation than with the other pacing points (AVD, RVOT or CRT).
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41

Pepe, Martino, Valeria Paradies, Fabrizio Resta, Alessandro Cafaro, Francesco Bartolomucci, Filippo Masi, Donato Quagliara y Stefano Favale. "Functional Mitral Regurgitation: If the Myocardium Is Guilty Do We Also Need to ‘Rehabilitate’ the Valve?" EMJ Cardiology, 24 de febrero de 2015, 38–47. http://dx.doi.org/10.33590/emjcardiol/10310014.

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Mitral regurgitation (MR) is the most frequent valvulopathy in the general population with an incidence that grows with age and is associated with a poor prognosis. Regardless of its primary cause, which can be both ischaemic and non-ischaemic cardiomyopathy, it finally activates a self-feeding process. Due to the complexity of mitral valve (MV) apparatus and its interaction with the myocardium, even the diagnosis could represent a challenge for physicians. Higher technological instruments such as 3D echocardiography and cardiac magnetic resonance could play an important role in the evaluation of MV. In this paper we reviewed the most salient aspects of functional MR pathophysiology as well as the current diagnostic methods. The management of functional mitral regurgitation (FMR) is even more challenging and controversial; the optimal approach, timing, and effectiveness of interventions are still debated. Treatment of FMR begins with optimal medical therapy for left ventricular dysfunction, including cardiac resynchronisation when indicated. While functional improvement after surgery is well established, the benefits in terms of survival are still questionable. Moreover, in patients with high perioperative risk there is a growing interest in emerging percutaneous techniques. Among a variety of medical, surgical, and percutaneous opportunities, authors support an accurate case-by-case evaluation to find a tailored and stepwise treatment according to anatomical features and patient comorbidities.
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42

Lam, S., MS Nazir, B. Campbell, M. Yazdani, G. Carr-White, S. Plein, A. Rinaldi y A. Chiribiri. "Left ventricular ejection fraction as an imaging biomarker to guide cardiac resynchronisation therapy in heart failure patients: a multimodal comparison of 2D and 3D echocardiography and CMR". European Heart Journal - Cardiovascular Imaging 22, Supplement_1 (1 de enero de 2021). http://dx.doi.org/10.1093/ehjci/jeaa356.358.

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Abstract Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): The authors acknowledge financial support from the Department of Health through the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy’s & St Thomas’ NHS Foundation Trust in partnership with King’s College London and King’s College Hospital NHS Foundation Trust and by the NIHR MedTech Co-operative for Cardiovascular Disease at Guy’s and St Thomas’ NHS Foundation Trust. This work was supported by the Wellcome/EPSRC Centre for Medical Engineering [WT 203148/Z/16/Z]. MSN was funded by a clinical lectureship awarded by the NIHR. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR, the DoH, EPSRC, MRC or the Wellcome Trust. Introduction – Imaging derived left ventricular ejection fraction (LVEF) has an important role to guide initiation of medical therapy and device insertion in patients with heart failure and reduced ejection fraction (HFrEF). Previous studies have reported the correlation and agreement of LVEF in various patient populations, but sparse evidence exists on patients with heart failure referred for Cardiac Resynchronisation Therapy (CRT) using 2D and 3D echocardiography (2DE & 3DE) and cardiovascular magnetic resonance (CMR). Objectives – To determine the correlation and agreement of LVEF as determined by 2DE, 3DE and CMR in a cohort of HF patients referred for assessment of CRT. Methods – Patients with suspected HFrEF referred for assessment for CRT therapy were included in this single centre study. Patients underwent 2DE, 3DE and CMR to derive LVEF, LVESV and LVEDV. Correlation was determined with Pearson’s correlation, agreement with Bland-Altman analysis and Cohen’s kappa analysis for agreement using a dichotomous cut off of LVEF ≤35% as a threshold for CRT insertion (Ponikowski, 2016). Results - 55 patients (mean age 71 ± 9.2, 76% male) were included. The mean LVEF for 2DE, 3DE, CMR and were 32.4 ± 8.6, 32.1 ± 9.6 and 30.3 ± 9.5 respectively. CMR had a significantly lower LVEF compared to 2DE (p = 0.03). There was good correlation between 3DE & CMR and 2DE & CMR, and excellent correlation between 3DE and 2DE for LVEF (Table 1). There was for trend for CMR to underestimate LVEF compared to 2DE and 3DE, with small biases although wide limits of agreement (Figure 1). There was excellent correlation of LVEDV and LVESV across all 3 techniques. CMR underestimated volumes compared to 2DE and 3DE with large biases and wide LOA. The kappa coefficient agreement at threshold level for CRT insertion (LVEF ≤35%) was fair for 3DE and CMR (0.379, p = 0.004) and 2DE and CMR (0.462, p = 0.001), and moderate for 3DE and 2DE (0.575, p ≤ 0.001). Conclusion – Whilst LVEF is not the only indicator to guide CRT insertion, it remains an important imaging parameter for clinical decision making. We observed large biases in left ventricular volumes between 2D, 3D and CMR. However, whilst the overall bias in LVEF is small, the wide limits of agreement (LOA) observed may represent an area of clinical uncertainty, which may impact on the dichotomous imaging threshold for CRT insertion. Comparison of indices between modalities LVEF Correlation (r) LVEF Bias & LOA (%±SD) EDV Correlation (r) EDV Bias & LOA (mL ± SD) ESV Correlation (r) ESV Bias & LOA (mL ± SD) 3DE vs CMR 0.676 (p &lt; 0.001) +1.75 ± 15.4 0.896 (p &lt; 0.001) -82.16 ± 42.8 0.937 (p &lt; 0.001) -61.3 ± 34.9 3DE vs 2DE 0.872 (p &lt; 0.001) +0.48 ± 4.5 0.909 (p &lt; 0.001) -10.31 ± 28.3 0.936 (p &lt; 0.001) -8.42 ± 20.5 2DE vs CMR 0.675 (p &lt; 0.001) +2.35 ± 14.6 0.876 (p &lt; 0.001) -67.35 ± 36.3 0.898 (p &lt; 0.001) -51.42 ± 30.1 Abstract Figure. Bland-Altman Plot LVEF by 3DE & CMR
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