Bibliografías temáticas / The immune response of T lymphocyte cell

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Literatura académica sobre el tema "The immune response of T lymphocyte cell"

Autor: Grafiati
Publicado: 10 de marzo de 2023
Última modificación: 31 de julio de 2025

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Artículos de revistas sobre el tema "The immune response of T lymphocyte cell"

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García Ramírez, Patricia, Marta Callejas Charavia, Raquel Oliva Martin, et al. "SARS-CoV-2-Specific T Lymphocytes Analysis in mRNA-Vaccinated Patients with B-Cell Lymphoid Malignancies on Active Treatment." Vaccines 12, no. 9 (2024): 961. http://dx.doi.org/10.3390/vaccines12090961.

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Background: Patients with B-lymphocyte malignancies (BCMs) receiving B-lymphocyte-targeted therapies have increased risk of severe COVID-19 outcomes and impaired antibody response to SARS-CoV-2 mRNA vaccination in comparison to non-hematologic oncologic patients or general population. Consequently, it is vital to explore vaccine-induced T-lymphocyte responses in patients referred for the understanding of immune protection against SARS-CoV2 infections. The objective of the present study was to analyze the recall immune responses carried out by T lymphocytes after two COVID-19 mRNA vaccine doses
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Sen, Pritha, William A. Charini, Ramu A. Subbramanian, et al. "Clonal Focusing of Epitope-Specific CD8+ T Lymphocytes in Rhesus Monkeys following Vaccination and Simian-Human Immunodeficiency Virus Challenge." Journal of Virology 82, no. 2 (2007): 805–16. http://dx.doi.org/10.1128/jvi.01038-07.

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ABSTRACT To afford the greatest possible immune protection, candidate human immunodeficiency virus (HIV) vaccines must generate diverse and long-lasting CD8+ T lymphocyte responses. In the present study, we evaluate T-cell receptor Vβ (variable region beta) gene usage and a CDR3 (complementarity-determining region 3) sequence to assess the clonality of epitope-specific CD8+ T lymphocytes generated in rhesus monkeys following vaccination and simian-human immunodeficiency virus (SHIV) challenge. We found that vaccine-elicited epitope-specific CD8+ T lymphocytes have a clonal diversity comparable
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Li, Lijin, Sharon M. Dial, Monika Schmelz, Margaret A. Rennels, and Neil M. Ampel. "Cellular Immune Suppressor Activity Resides in Lymphocyte Cell Clusters Adjacent to Granulomata in Human Coccidioidomycosis." Infection and Immunity 73, no. 7 (2005): 3923–28. http://dx.doi.org/10.1128/iai.73.7.3923-3928.2005.

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ABSTRACT The in situ immunologic response in human coccidioidomycosis remains undefined. To explore this further, pulmonary necrotizing coccidioidal granulomata were examined using immunohistochemical staining for lymphocyte subsets and for the cytokines interleukin-10 (IL-10) and gamma interferon (IFN-γ). Discrete perigranulomatous lymphocytic clusters were seen in eight of nine tissues examined. In these tissues, T lymphocytes (CD3+) significantly outnumbered B lymphocytes (CD20+) in the mantle area of the granulomata (P = 0.028), whereas the clusters were composed of roughly equal numbers o
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Baszler, Timothy V., Varda Shkap, Waithaka Mwangi, et al. "Bovine Immune Response to Inoculation with Neospora caninum Surface Antigen SRS2 Lipopeptides Mimics Immune Response to Infection with Live Parasites." Clinical and Vaccine Immunology 15, no. 4 (2008): 659–67. http://dx.doi.org/10.1128/cvi.00436-07.

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ABSTRACT Infection of cattle with Neospora caninum protozoa, the causative agent of bovine protozoal abortion, results in robust cellular and humoral immune responses, particularly CD4+ T-lymphocyte activation and gamma interferon (IFN-γ) secretion. In the present study, N. caninum SRS2 (NcSRS2) T-lymphocyte-epitope-bearing subunits were incorporated into DNA and peptide preparations to assess CD4+ cell proliferation and IFN-γ T-lymphocyte-secretion immune responses in cattle with predetermined major histocompatibility complex (MHC) genotypes. In order to optimize dendritic-cell processing, Nc
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Kasaian, M. T., and C. A. Biron. "Effects of cyclosporin A on IL-2 production and lymphocyte proliferation during infection of mice with lymphocytic choriomeningitis virus." Journal of Immunology 144, no. 1 (1990): 299–306. http://dx.doi.org/10.4049/jimmunol.144.1.299.

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Abstract The immunosuppressive agent, cyclosporin A (CsA) blocks production of IL-2 by lymphocytes in vitro, and impairs immune responses in vivo. During infection of mice with lymphocytic choriomeningitis virus (LCMV), IL-2 is produced by spleen lymphocytes with a time course corresponding to that of T cell activation and proliferation, but distinct from NK cell activation and proliferation. To evaluate the requirement for IL-2 in supporting lymphocyte proliferation in vivo, and to investigate the mechanisms of CsA-induced immunosuppression, the effects of CsA on LCMV-elicited responses were
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Arsenio, Janilyn, Boyko Kakaradov, Gene Yeo, and John Chang. "Specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single cell gene expression analyses (P1448)." Journal of Immunology 190, no. 1_Supplement (2013): 117.24. http://dx.doi.org/10.4049/jimmunol.190.supp.117.24.

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Abstract Although it is well established that heterogeneity of lymphocyte fate is an essential feature of adaptive immune responses, how and when these divergent cellular fates are specified remains unknown. It has been previously shown that a T lymphocyte responding to a microbial infection can undergo asymmetric division to yield two daughter cells that are differentially fated from inception. Such a model suggests that the progeny arising from each of the two differentially fated daughter cells might exhibit distinct patterns of gene expression. Because strategies analyzing bulk cell popula
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Parkman, Robertson, Geoff Cohen, Shelley L. Carter, et al. "Antigen-Specific T Lymphocyte Function Following Unrelated Cord Blood Transplantation (UCBT)." Blood 106, no. 11 (2005): 3032. http://dx.doi.org/10.1182/blood.v106.11.3032.3032.

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Abstract The T lymphocytes contained in cord blood are naïve and do not have antigen-specific function. Since the antigen-specific T lymphocytes contained in other hematopoietic stem cell (HSC) source may contribute to protective cellular immunity following transplantation, it has been hypothesized that the recipients of cord blood transplantation (CBT) might be at increased risk of opportunistic infections. The development of antigen-specific T lymphocyte function was measured in 153 recipients of unrelated cord blood transplants (UCBT) by determining antigen-specific T lymphocyte proliferat
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Puntigam, Lisa K., Sandra S. Jeske, Marlies Götz, et al. "Immune Checkpoint Expression on Immune Cells of HNSCC Patients and Modulation by Chemo- and Immunotherapy." International Journal of Molecular Sciences 21, no. 15 (2020): 5181. http://dx.doi.org/10.3390/ijms21155181.

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Endogenous control mechanisms, including immune checkpoints and immunosuppressive cells, are exploited in the process of tumorigenesis to weaken the anti-tumor immune response. Cancer treatment by chemotherapy or immune checkpoint inhibition can lead to changes of checkpoint expression, which influences therapy success. Peripheral blood lymphocytes (PBL) and tumor-infiltrating lymphocytes (TIL) were isolated from head and neck squamous cell carcinoma (HNSCC) patients (n = 23) and compared to healthy donors (n = 23). Immune checkpoint expression (programmed cell death ligand 1 (PD-1), tumor nec
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Manuel, Edwin R., William A. Charini, Pritha Sen, et al. "Contribution of T-Cell Receptor Repertoire Breadth to the Dominance of Epitope-Specific CD8+ T-Lymphocyte Responses." Journal of Virology 80, no. 24 (2006): 12032–40. http://dx.doi.org/10.1128/jvi.01479-06.

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ABSTRACT Dominant epitope-specific CD8+ T-lymphocyte responses play a central role in controlling viral spread. We explored the basis for the development of this focused immune response in simian immunodeficiency virus (SIV)- and simian-human immunodeficiency virus (SHIV)-infected rhesus monkeys through the use of two dominant (p11C and p199RY) and two subdominant (p68A and p56A) epitopes. Using real-time PCR to quantitate T-cell receptor (TCR) variable region beta (Vβ) family usage, we show that CD8+ T-lymphocyte populations specific for dominant epitopes are characterized by a diverse Vβ rep
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Trad, Malika, Alexandrine Gautheron, Jennifer Fraszczak, et al. "T Lymphocyte Inhibition by Tumor-Infiltrating Dendritic Cells Involves Ectonucleotidase CD39 but Not Arginase-1." BioMed Research International 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/891236.

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T lymphocytes activated by dendritic cells (DC) which present tumor antigens play a key role in the antitumor immune response. However, in patients suffering from active cancer, DC are not efficient at initiating and supporting immune responses as they participate to T lymphocyte inhibition. DC in the tumor environment are functionally defective and exhibit a characteristic of immature phenotype, different to that of DC present in nonpathological conditions. The mechanistic bases underlying DC dysfunction in cancer responsible for the modulation of T-cell responses and tumor immune escape are
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Tesis sobre el tema "The immune response of T lymphocyte cell"

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Vargas, Cuero Ana Laura. "Study of CD8'+T lymphocyte responses against human herpesviruses." Thesis, Open University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342897.

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Debock, Isabelle. "Study of the development of Th17-type immune response in early life." Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209700.

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Par rapport à l’adulte, le nouveau-né présente une susceptibilité accrue aux agents infectieux et au développement d’allergies. Une polarisation de l’immunité acquise vers des réponses de type Th2, productrices d’IL-4, d’IL-5 et d’IL-13, et un défaut de réponses immunes de type Th1, sécrétant de l’IFN-γ, peuvent rendre compte de ce statut immunitaire particulier. De plus, un retard de production et de maturation des anticorps, caractéristiques de l’immunité humorale, s’observe en début de vie. <p>Récemment, de nouveaux lymphocytes T auxiliaires ont été décrits, les lymphocytes Th17, producteur
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Galle, Cécile. "Inflammatory and helper T lymphocyte responses in human abdominal aortic aneurysm." Doctoral thesis, Universite Libre de Bruxelles, 2006. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210815.

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Summary of the work<p>Abdominal aortic aneurysm (AAA) is a chronic degenerative disease that usually affects men over 65 years with an estimated prevalence of 5%. Aneurysm rupture represents a catastrophic event which carries a mortality rate of almost 90%. Current therapeutic options for AAAs measuring 5.5 cm in diameter or larger are based on prophylactic surgery, including conventional open reconstruction and endovascular stent-graft insertion. For patients with small asymptomatic AAAs (4.0 up to 5.5 cm in diameter), evidence from two recent large randomized controlled trials indicates no l
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Jin, Siya. "Quantitative comparison of the human immunodeficiency virus-1 and Epstein-Barr virus specific cytotoxic T lymphocyte responses." Thesis, Open University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283078.

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Fulton, Jonathan Reid. "Intestinal and systemic cytotoxic T lymphocyte and humoral immune responses to oral and parenteral reovirus infection." Morgantown, W. Va. : [West Virginia University Libraries], 2006. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=4474.

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Thesis (Ph. D.)--West Virginia University, 2006.<br>Title from document title page. Document formatted into pages; contains xi, 288 p. : ill. Vita. Includes abstract. Includes bibliographical references.
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Shi, Zheng Isabelle. "Prolifération et capacité cytotoxique des lymphocytes T infiltrant les tumeurs induites par les cellules malignes autologues de lymphomes B : étude de 85 clones T issus de 9 patients." Université Joseph Fourier (Grenoble ; 1971-2015), 1994. http://www.theses.fr/1994GRE10215.

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Les til-t provenant de 20 lmnh b de type histologique/cytologique varies ont été étudiés et 174 clones t ont été générés dans 9 des cas. 4 groupes prolifératifs ont été identifiés sur la base de prolifération des til-t. Les pourcentages de clones proliférant dans ces 4 groupes sont respectivement de 63%, 70% et 56%, et 10%. Dans les lmnh de forte malignite, 25% (5/20) des clones t prolifèrent sous l'effet des bm alors que dans les lmnh de faible malignite, il y en a 55% (36/65) (p < 0,05). Il en est de même pour leurs capacités de dissémination : dans les lmnh localisés (stades i et ii), 70% (
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Huygens, Ariane. "Fetal T cell response to human congenital cytomegalovirus infection." Doctoral thesis, Universite Libre de Bruxelles, 2013. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209450.

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Les nouveau-nés et les jeunes enfants ont une susceptibilité plus élevée aux infections par rapport aux enfants plus âgés et aux adultes. Cette caractéristique est en partie attribuée à l’immaturité de leur système immunitaire qui est associée à une capacité limitée à développer des réponses immunitaires à médiation cellulaire. L’infection par le cytomégalovirus (HCMV) est la cause la plus fréquente d’infection congénitale chez l’Homme et une cause majeure de surdité et de retard mental. En Belgique, le dépistage anténatal de l’infection primaire par le HCMV chez les femmes enceintes offre l’o
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Zuccolotto, Peter. "T-cell development in the Tammar wallaby (Macropus eugenii)." Thesis, View thesis, 2000. http://handle.uws.edu.au:8081/1959.7/391.

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Marsupials and eutherians are the two principal groups of modern mammals. Mammalian immunological studies, to date, have focused on eutherian systems with little or no comprehensive work having been carried out on marsupials. This project investigates the functional and developmental aspects of T-cell responses in the marsupial, Macropus eugenii (Tammar wallaby) in both adults and pouch young at various stages of development. Determination of the age at which the Tammar wallaby immune system becomes competent has been examined through the use of cellular and molecular studies carried out on de
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Zuccolotto, Peter. "T-cell development in the Tammar wallaby (Macropus eugenii)." View thesis, 2000. http://library.uws.edu.au/adt-NUWS/public/adt-NUWS20030828.145055/index.html.

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Frenati, Melania. "Role of CYBR, a cytohesin binder and regulator scaffold protein, in cell-mediated immune response in vivo." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3423114.

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Cybr (Cytohesin binder and regulator) is an adaptor protein involved in the assembly and recruitment of protein complexes associated with intracellular trafficking and signaling. Cybr has attracted attention as a potential key contributor to molecular mechanisms governing cells of the immune system due to its exclusive expression in cells of hematopoietic origin. Cybr interacts with members of the ADP ribosylation factor (ARF)-activating cytohesin family, mainly cytohesin-1, and it is involved in the cytohesin-1-mediated adhesion of LFA-1 to ICAM-1. Cybr expression is highly and rapidly respon
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Libros sobre el tema "The immune response of T lymphocyte cell"

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Alexander, Michael A. Immune-based cancer treatment: The T lymphocyte response. CRC Press, 2011.

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Alexander, Michael A. Immune-based cancer treatment: The T lymphocyte response. CRC Press, 2011.

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Marc, Feldmann, and Mitchison N. Avrion, eds. Immune regulation. Humana Press, 1985.

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Liu, Yang. The costimulatory pathway for T cell response. R.G. Landes, 1994.

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Rook, G. A. W. 1946- and Lightman Stafford L, eds. Steroid hormones and the T-cell cytokine profile. Springer, 1997.

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Miami Bio/Technology Winter Symposium (1990 Miami, Fla.). Advances in gene technology: The molecular biology of immune diseases and the immune reponse : proceedings of the 1990 Miami Bio/Technology Winter Symposia. IRL Press, 1990.

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B, Schook Lawrence, Tew John G, and International RES Symposium (1987 : Richmond, Va.), eds. Antigen presenting cells: Diversity, differentiation, and regulation : proceedings of a symposium held in Richmond, Virginia, March 26-29, 1987. Liss, 1988.

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1943-, Watson James D., and Marbrook John, eds. Recognition and regulation in cell-mediated immunity. M. Dekker, 1985.

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Z, Atassi M., and Abbott Laboratories, eds. Immunobiology of proteins and peptides IV: T-cell recognition and antigen presentation. Plenum Press, 1987.

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Na, Songqing, and Chandrasekar Venkataraman Iyer. Effector CD4+ T cells in health and disease 2007. Transworld Research Network, 2007.

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Capítulos de libros sobre el tema "The immune response of T lymphocyte cell"

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Greco, Raffaella, and Dominique Farge. "CART Cells and Other Cell Therapies (ie MSC, Tregs) in Autoimmune Diseases." In The EBMT Handbook. Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-44080-9_93.

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AbstractAuto-immune diseases (AD) are heterogeneous conditions, characterized by polyclonal activation of the immune system with a defect of B or T lymphocyte selection and altered lymphocytic reactions to auto-antigens components (Burnet 1959a, b), although it is rare to identify a single antigenic epitope. The native immune system and its tissue environment play an important role to determine if exposure to a given antigen will induce an immune response or tolerance or anergy. The role of the genes coding for the major histocompatibility system molecules, but also of many other genes, is imp
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Müller, Sabina, Liza Filali, Marie-Pierre Puissegur, and Salvatore Valitutti. "Measuring CTL Lytic Granule Secretion and Target Cell Membrane Repair by Fluorescent Lipophilic Dye Uptake at the Lytic Synapse." In The Immune Synapse. Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-3135-5_30.

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AbstractCD8+ cytotoxic T lymphocytes (CTL) play a key role in anti-tumor immune response. They are therefore at the heart of current immunotherapy protocols against cancer. Despite current strategies to potentiate CTL responses, cancer cells can resist CTL attack, thus limiting the efficacy of immunotherapies. To optimize immunotherapy, it is urgent to develop rapid assays allowing to assess CTL-cancer cell confrontation at the lytic synapse.In this chapter, we describe a flow cytometry-based method to simultaneously assess the extent of CTL activation and of tumor cell reparative membrane tur
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Economopoulou, Panagiota, and Amanda Psyrri. "Patterns of Response to Immune Oncology Drugs: How Relevant Are They in SCCHN?" In Critical Issues in Head and Neck Oncology. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-23175-9_14.

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AbstractDuring the past few years, we have been witnesses of a critical juncture in the history of cancer therapy; indeed, immunotherapy has been introduced initially in melanoma trials and has been gradually incorporated in the treatment algorithm of a variety of malignancies in multiple settings. Immune checkpoint inhibitors (ICIs), the most widely used immunotherapy drugs, are monoclonal antibodies that target specific immune checkpoints such as Programmed Cell Death-1 (PD-1) and Cytotoxic T-lymphocyte-Associated protein 4 (CTLA-4). Response to ICIs is characterized by marked durability, bu
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Ayodele, Olubukola, and Lillian L. Siu. "New Drugs for Recurrent or Metastatic Nasopharyngeal Cancer." In Critical Issues in Head and Neck Oncology. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-63234-2_23.

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AbstractChemotherapy has been the backbone for the treatment of recurrent or metastatic nasopharyngeal carcinoma (RMNPC), which remains an incurable disease. Currently the most active area of therapeutic investigations in RMNPC is in immunotherapy, especially after the results of five anti-programmed death-1 (anti-PD-1) antibodies, i.e. pembrolizumab, nivolumab, camrelizumab, toripalimab and tislelizumab, have demonstrated monotherapy objective response rates of 21%–43%. Combinations using anti-PD1/L1 antibodies as backbone to evaluate their additivity or synergy with cytotoxic chemotherapy, m
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Falkenburg, J. H. Frederik, Christoph Schmid, Hans Joachim Kolb, and Jürgen Kuball. "Delayed Transfer of Immune Cells or the Art of Donor Lymphocyte Infusion (DLI) 2.0." In The EBMT Handbook. Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-44080-9_59.

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AbstractIn the context of an allogeneic hematopoietic cell transplantation (HCT), the interplay between host and donor immune cells is considered to be the primary mechanism responsible for graft-versus-leukemia (GVL) reactivity and also able to mediate graft-versus-host disease (GVHD) (Schmid et al. 2021). The tissue specificity of the immune response determines the balance between GVL and GVHD, as well as tropism of GVHD. The main population for success and failure of HCT and DLIs originates from αβT cells. Other subsets are also key modulators of efficacy. For example, NK cells most likely
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Ragbetli, Murat Cetin, and Aysenur Kaya. "Histopathological Changes in Diabetic Pancreas." In Current Multidisciplinary Approach to Diabetes Mellitus Occurrence Mechanism. Nobel Tip Kitabevleri, 2023. http://dx.doi.org/10.69860/nobel.9786053359104.3.

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Histopathological changes in the diabetic pancreas are characterized by several key alterations that impact its structure and function. In type 1 diabetes mellitus (T1DM), autoimmune destruction of insulin-producing beta cells within the pancreatic islets results in their selective loss, termed insulitis. This process involves infiltration of immune cells such as T lymphocytes and macrophages into the islets, leading to progressive beta cell destruction and ultimately insulin deficiency. In contrast, type 2 diabetes mellitus (T2DM) is associated with insulin resistance and eventual beta cell d
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Blaise, Didier, and Sabine Fürst. "Post-CAR-T Cell Therapy (Consolidation and Relapse): Lymphoma." In The EBMT/EHA CAR-T Cell Handbook. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-94353-0_33.

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AbstractEven after a decade of use, CAR-T cell therapy for non-Hodgkin lymphoma (NHL) is still evolving, and disease control is now the main concern in the majority of experienced centres. Indeed, despite highly appealing objective response (OR) rates in refractory patients, the long-term overall survival (OS) of this population has only slightly improved. Pivotal studies have suggested that 2-year OS rates do not surpass 30%, even though results improve when complete response (CR) is achieved within the first 3 months after treatment (Wang et al. 2020; Schuster et al. 2019; Neelapu et al. 201
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Afsar, Atefeh, Filipe Martins, Bruno M. P. M. Oliveira, and Alberto A. Pinto. "Immune Response Model Fitting to CD4$$^+$$ T Cell Data in Lymphocytic Choriomeningitis Virus LCMV infection." In Springer Proceedings in Mathematics & Statistics. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-78163-7_1.

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Tetikkurt, Cuneyt. "Immunopathology of Sarcoidosis." In Sarcoidosis. Nobel Tip Kitabevleri, 2023. http://dx.doi.org/10.69860/nobel.9786053359128.3.

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The immunopathology of sarcoidosis lies at the heart of its complex nature and clinical manifestations. This chapter delves into the intricate interactions of the immune system that underpin the development and progression of sarcoidosis. Central to this understanding are the formation of granulomas-aggregates of immune cells-and the dysregulation of immune responses that characterize the disease. Exploring the roles of T lymphocytes, macrophages, cytokines, and other immune mediators, we aim to unravel the mechanisms driving granuloma formation and tissue damage in affected organs.
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Davis, M. M., N. R. J. Gascoigne, T. Lindsten, C. Goodnow, and Y. Chien. "Murine T-Cell Receptor Genes." In Mechanisms of Lymphocyte Activation and Immune Regulation. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-5323-2_2.

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Actas de conferencias sobre el tema "The immune response of T lymphocyte cell"

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Greenfield, Leonard, Michael Ayer, Anthony Samuels, Olusola Lawal, and Lealon Martin. "Optimization-Based Modeling of T-Lymphocyte Cell-Cell Contact Leading to Immune Response." In 10th AIAA/ISSMO Multidisciplinary Analysis and Optimization Conference. American Institute of Aeronautics and Astronautics, 2004. http://dx.doi.org/10.2514/6.2004-4383.

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Ma, Chao, Ann Cheung, Begonya Comin-Anduix, et al. "Abstract 4839: Adoptive cell transfer of transgenic T cells elicited a two-wave antitumor cellular immune response consisted of engineered and endogenous T lymphocytes with different sets of functions." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-4839.

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Clayton Abreu da Silva, Nadyson, Heloisa Landin Gomes, Cristiane Brasil Francisco, Elisabete Landim Gomes Siqueira, Mariana Manhães do Amaral Peixoto, and Maurício Rocha Calomeni. "The Efficiency of an online physical exercises program in elderly lifestyle on COVID-19 pandemic." In 7th International Congress on Scientific Knowledge. Biológicas & Saúde, 2021. http://dx.doi.org/10.25242/8868113820212383.

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The moderate and periodic practice of physical exercise promotes cell protection against viral infection due the balance between cellular immune response, determined directly by T lymphocytes, and humoral cells in which specific antibodies participate, produced by mature B lymphocytes. The countries members of the United Nations Organization (UNO) approved the Aging International Action Plan (AIAP) where are proposed strategies to support the prevention of mental disorders, the treatment of aged illness, as well the strengthening of a care network and support to aged people with the participat
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Tsekhanovich, D., A. Starastsin, A. Dybau, and D. Nizheharodava. "Y6T-LYMPHOCYTES PHENOTYPE IN PATIENTS WITH INFLAMMATORY BOWEL DISEASES." In SAKHAROV READINGS 2022: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute of Belarusian State University, 2022. http://dx.doi.org/10.46646/sakh-2022-2-68-71.

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YST-сells role in inflammatory bowel disease is still not fully investigated: on the one hand, they are thought to be involved in dysregulation of the immune response to gastrointestinal commensal bacteria in genetically susceptible individuals and, on the other hand, YST-cells may initiate repair of damaged intestinal epithelium and exhibit immunoreg-ulatory effects. The composition of T-lymphocytes subsets (авТ-cells, YST-cells) and the expression of functional molecules (TLR4+, CD314+, CD8+, CD45RO+) on circulating YST-cells in patients with inflammatory bowel disease were characterized in
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Wang, Binbin, Kun Wang, Eytan Ruppin, and Peng Jiang. "536 Decoupling cytotoxic T lymphocyte and exhausted T lymphocyte transcriptomic signatures enhances immune checkpoint inhibitors response prediction in melanoma." In SITC 37th Annual Meeting (SITC 2022) Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/jitc-2022-sitc2022.0536.

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Chen, Yu-Li, Ming-Cheng Chang, Chia-Yen Huang, et al. "Abstract 3536: Depletion of regulatory T lymphocytes reverses the imbalance between Pro- and anti-tumor immunities via enhancing antigen-specific T cell immune responses." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-3536.

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Griffith, J., L. Faustino, and A. Luster. "Regulatory T Cell Subsets Differentially Regulate the Immune Response to Influenza." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5829.

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Rocha, Aline Carvalho. "Tumor-associated macrophages and their relationship with histopathological prognostic factors in breast cancer." In XXVI Brazilian Mastology Congress. Mastology, 2024. https://doi.org/10.29289/259453942024v34s2002.

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Introduction: The immune system plays a leading role in the tumor microenvironment due to the unique characteristics of its cells, such as macrophages, lymphocytes, among others. Tumor-associated macrophages (TAM) constitute up to 50% of the tumor mass in breast cancer and are vital to the innate immune response. Recently, numerous studies have been published evaluating the relationship between tumor-infiltrating lymphocytes (TILs) and TAMs in triple-negative breast tumors. High levels of TILs (CD8+ T cells) may be associated with a better prognosis, while high levels of TAMs are linked to poo
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Bauknight, Dustin, Andrew Buckner, Lindsey Brinton, Timothy Bullock, and Kimberly Kelly. "Abstract 4147: T cell targeted peptides for monitoring immune response in melanoma." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-4147.

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Kwiecień, Iwona, Tomasz Skirecki, Małgorzata Polubiec-Kownacka, Dariusz Dziedzic, and Joanna Domagała-Kulawik. "Cytotoxic T cell antigen 4 and the status of T cell activation in lung cancer: local vs. systemic immune response." In ERS International Congress 2017 abstracts. European Respiratory Society, 2017. http://dx.doi.org/10.1183/1393003.congress-2017.oa4863.

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Informes sobre el tema "The immune response of T lymphocyte cell"

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Splitter, Gary, Zeev Trainin, and Yacov Brenner. Lymphocyte Response to Genetically Engineered Bovine Leukemia Virus Proteins in Persistently Lymphocytic Cattle from Israel and the U.S. United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7570556.bard.

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The goal of this proposal was to identify proteins of BLV recognized by lymphocyte subpopulations and determine the contribution of these proteins to viral pathogenesis. Our hypothesis was that BLV pathogenesis is governed by the T-cell response and that the immune system likely plays an important role in controlling the utcome of infection. Our studies presented in ths final report demonstrate that T cell competency declines with advancing stages of infection. Dramatic differences were observed in lymphocyte proliferation to recombinant proteins encoded by BLV gag (p12, p15, and p24) and env
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Baszler, Timothy, Igor Savitsky, Christopher Davies, Lauren Staska, and Varda Shkap. Identification of bovine Neospora caninum cytotoxic T-lymphocyte epitopes for development of peptide-based vaccine. United States Department of Agriculture, 2006. http://dx.doi.org/10.32747/2006.7695592.bard.

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The goal of the one-year feasibility study was to identify specific cytotoxic T-lymphocyte (CTL) epitopes to Neosporacaninum in the natural bovine host in order to make progress toward developing an effective peptide-based vaccine against bovine neosporosis. We tested the hypothesis that: N. caninum SRS2 peptides contain immunogenicCTLepitope clusters cross-presented by multiple bovine MHC-I and MHC-IIhaplotypes. The specific objectives were: (1) Map bovine CTLepitopes of N. caninum NcSRS-2 and identify consensus MHC-I and class-II binding motifs; and (2) Determine if subunit immunization with
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Banai, Menachem, and Gary Splitter. Molecular Characterization and Function of Brucella Immunodominant Proteins. United States Department of Agriculture, 1993. http://dx.doi.org/10.32747/1993.7568100.bard.

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The BARD project was a continuation of a previous BARD funded research project. It was aimed at characterization of the 12kDa immunodominant protein and subsequently the cloning and expression of the gene in E. coli. Additional immunodominant proteins were sought among genomic B. abortus expression library clones using T-lymphocyte proliferation assay as a screening method. The 12kDa protein was identified as the L7/L12 ribosomal protein demonstrating in the first time the role a structural protein may play in the development of the host's immunity against the organism. The gene was cloned fro
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Leitner, Gabriel, and Naomi Balaban. Novel Immunotherapeutic Agent for the Treatment and Prevention of Staphylococcal Mastitis in Dairy Cows. United States Department of Agriculture, 2009. http://dx.doi.org/10.32747/2009.7709880.bard.

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Staphylococci are the most common and costly mammary disease of dairy cattle worldwide. TRAP, a membrane associated 167AA protein, is highly conserved among staphylococci. The aims of this study were to test the safety and efficacy of recombinant TRAP (rTRAP) vaccine in dairy animals. The vaccine was safe as 2-3 subcutaneous injections of rTRAP (54–100μg) with adjuvant ISA 206 to cows and goats did not lead to any abnormal symptoms of sensitivity to the vaccine. The rTRAP vaccine was immunogenic and caused the induction of a humoral immune response that remained high for at least 160 days post
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Leitner, Gabriel, and Naomi Balaban. Novel Immunotherapeutic Agent for the Treatment and Prevention of Staphylococcal Mastitis in Dairy Cows. United States Department of Agriculture, 2009. http://dx.doi.org/10.32747/2009.7695866.bard.

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Staphylococci are the most common and costly mammary disease of dairy cattle worldwide. TRAP, a membrane associated 167AA protein, is highly conserved among staphylococci. The aims of this study were to test the safety and efficacy of recombinant TRAP (rTRAP) vaccine in dairy animals. The vaccine was safe as 2-3 subcutaneous injections of rTRAP (54–100μg) with adjuvant ISA 206 to cows and goats did not lead to any abnormal symptoms of sensitivity to the vaccine. The rTRAP vaccine was immunogenic and caused the induction of a humoral immune response that remained high for at least 160 days post
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Mohanakumar, Thalachallour. Definition of the T Cell-Mediated Immune Response to Mammaglobin, a Novel Breast Cancer-Associated Protein. Defense Technical Information Center, 2001. http://dx.doi.org/10.21236/ada403328.

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Mohanakumar, Thalachallour. Definition of the T Cell-Mediated Immune Response to Mammaglobin, a Novel Breast Cancer-Associated Protein. Defense Technical Information Center, 2002. http://dx.doi.org/10.21236/ada410575.

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Mohanakumar, Thalachallour. Definition of the T Cell-Mediated Immune Response to Mammaglobin, a Novel Breast Cancer-Associated Protein. Defense Technical Information Center, 2000. http://dx.doi.org/10.21236/ada391781.

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McElwain, Terry, Eugene Pipano, Guy Palmer, Varda Shkap, Stephen Hines, and Douglas Jasmer. Protection of Cattle Against Babesiosis: Immunization with Recombinant DNA Derived Apical Complex Antigens of Babesia bovis. United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7612835.bard.

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Bovine babesiosis caused by Babesia bovis continues to be a significant deterrent to global livestock production. Current control methods have both biological and technical drawbacks that have stimulated research on improved methods of vaccination. This BARD project has focused on characterization of candidate Babesia bovis vaccine antigens located in the apical complex, a unique group of subcellular organelles - including rhoptries, micronemes, and spherical bodies - involved in the invation of erythrocytes. Spherical bodies and rhoptries were partially purified and their contents characteriz
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Hirankarn, Nattiya, Tanapat Palaga, Yingyos Avihingsanon, and Pimpayao Sodsai. The characterization of the two new genes, PTGS2 and PSN2 involving in the T lymphocyte apoptosis of lupus patients: Role of genetic polymorphism and epigenetic alteration. Chulalongkorn University, 2006. https://doi.org/10.58837/chula.res.2006.28.

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Systemic lupus erthematosus (SLE) is a prototype of autoimmune disease characterized by tissue deposition of autoantibody immune complex formation. However, etiology of disease remains unclarified. Defects of T lymphocytes lead to loss of immunological tolerance and support autoantibody production suggested that they may consistently have a central role in pathogenesis of SLE. Notch signaling is an evolutionarily conserved pathway responsible for thymocyte development, activation, proliferation, differentiation and T cell functions. Several evidences suggest Notch signaling involvement in auto
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