Bibliografías temáticas / Thymine nucleotide

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Literatura académica sobre el tema "Thymine nucleotide"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 6 de febrero de 2022

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Artículos de revistas sobre el tema "Thymine nucleotide"

Ślepokura, Katarzyna Anna. "3′:5′-Cyclic nucleotides: two sodium salts of cdTMP." Acta Crystallographica Section C Structural Chemistry 72, no. 1 (2016): 35–47. http://dx.doi.org/10.1107/s2053229615022536.

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3′:5′-Cyclic nucleotides play an outstanding role in signal transduction at the cellular level but, in spite of comprehensive knowledge of the biological role of cyclic nucleotides, their structures are not established fully. Two hydrated sodium salts of thymidine 3′:5′-cyclic phosphate (cdTMP, C10H12N2O7P), namely sodium thymidine 3′:5′-cyclic phosphate heptahydrate, Na+·C10H12N2O7P−·7H2O or Na(cdTMP)·7H2O, (I), and sodium thymidine 3′:5′-cyclic phosphate 3.7-hydrate, Na+·C10H12N2O7P−·3.7H2O or Na(cdTMP)·3.7H2O, (II), have been obtained in crystalline form and structurally characterized, reve

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Lee, Hyeon Cheol, Jin Ha Kim, Jin Sook Kim, Wonhee Jang, and Sang Yong Kim. "Fermentative Production of Thymidine by a Metabolically Engineered Escherichia coli Strain." Applied and Environmental Microbiology 75, no. 8 (2009): 2423–32. http://dx.doi.org/10.1128/aem.02328-08.

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ABSTRACT Thymidine is an important precursor in the production of various antiviral drugs, including azidothymidine for the treatment of AIDS. Since thymidine-containing nucleotides are synthesized only by the de novo pathway during DNA synthesis, it is not easy to produce a large amount of thymidine biologically. In order to develop a host strain to produce thymidine, thymidine phosphorylase, thymidine kinase, and uridine phosphorylase genes were deleted from an Escherichia coli BL21 strain to develop BLdtu. Since the genes coding for the enzymes related to the nucleotide salvage pathway were

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Washington, M. T., L. Prakash, and S. Prakash. "Mechanism of nucleotide incorporation opposite a thymine-thymine dimer by yeast DNA polymerase." Proceedings of the National Academy of Sciences 100, no. 21 (2003): 12093–98. http://dx.doi.org/10.1073/pnas.2134223100.

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Carlson, Karissa D., та M. Todd Washington. "Mechanism of Efficient and Accurate Nucleotide Incorporation Opposite 7,8-Dihydro-8-Oxoguanine by Saccharomyces cerevisiae DNA Polymerase η". Molecular and Cellular Biology 25, № 6 (2005): 2169–76. http://dx.doi.org/10.1128/mcb.25.6.2169-2176.2005.

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ABSTRACT Most DNA polymerases incorporate nucleotides opposite template 7,8-dihydro-8-oxoguanine (8-oxoG) lesions with reduced efficiency and accuracy. DNA polymerase (Pol) η, which catalyzes the error-free replication of template thymine-thymine (TT) dimers, has the unique ability to accurately and efficiently incorporate nucleotides opposite 8-oxoG templates. Here we have used pre-steady-state kinetics to examine the mechanisms of correct and incorrect nucleotide incorporation opposite G and 8-oxoG by Saccharomyces cerevisiae Pol η. We found that Pol η binds the incoming correct dCTP opposit

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Kohalmi, Susanne E., and Bernard A. Kunz. "Mutationtal specificity of thymine nucleotide depletion in yeast." Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 289, no. 1 (1993): 73–81. http://dx.doi.org/10.1016/0027-5107(93)90132-y.

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Morganroth, Pamela A., and Philip C. Hanawalt. "Role of DNA Replication and Repair in Thymineless Death in Escherichia coli." Journal of Bacteriology 188, no. 14 (2006): 5286–88. http://dx.doi.org/10.1128/jb.00543-06.

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ABSTRACT Inhibition of DNA replication with hydroxyurea during thymine starvation of Escherichia coli shows that active DNA synthesis is not required for thymineless death (TLD). Hydroxyurea experiments and thymine starvation of lexA3 and uvrA DNA repair mutants rule out unbalanced growth, the SOS response, and nucleotide excision repair as explanations for TLD.

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Ramadan, H. A. I., A. Galal, M. M. Fathi, Fiky El, and H. A. Yakoub. "Characterization of two Egyptian native chicken breeds using genetic and immunological parameters." Biotehnologija u stocarstvu 27, no. 1 (2011): 1–16. http://dx.doi.org/10.2298/bah1101001r.

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In order to identify and characterize our native chicken breeds we used two approaches, one of them is genetic and the other concerns with the immunological status of the chickens. In this study, the first 539 bases of the mtDNA D-loop region of two Egyptian native breeds (Fayoumi and Dandarawi, from El-Fayoum research station) were amplified and sequenced. The alignment results showed an approximate tandem repeat of 60-base units with the first 34 nucleotides being exact. These 34-base units were completely identical and conserved in both Egyptian and GenBank database samples. The multiple al

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Kunz, B. A., G. R. Taylor, and R. H. Haynes. "Mating-type switching in yeast is induced by thymine nucleotide depletion." Molecular and General Genetics MGG 199, no. 3 (1985): 540–42. http://dx.doi.org/10.1007/bf00330772.

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Suriana, Suriana, Jamili Jamili, and Parakkasi Parakkasi. "Karakteristik Gen Sitokrom C Oksidase Sub Unit I (CO1) Lebah Liar Apis cerena (Hymenoptera: apidae) Asal Pulau Hoga Sulawesi Tenggara." Jurnal Veteriner 19, no. 1 (2018): 116. http://dx.doi.org/10.19087/jveteriner.2018.19.1.116.

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The study was conducted to assess the caracteristic of cytochrome C oxidase subunit I (COI) gene on wild honey bee Apis cerena, and detection of barcode sites from these gene. A total fifteen individual A. cerena were collected from Hoga Island, Southeast Sulawesi. Genomic DNA was extracted from torax, then amplified by PCR method and than sequenced. Sequencing result characterized their nucleotide and amino acid content. The results showed that 595 nucleotides at the 5' end of COI gene of A. cerena very conserved at the most of the sites. Nucleotide dominated by thymine and adenine bases (± 7

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Liboska, Radek, Milena Masojídková, and Ivan Rosenberg. "Carbocyclic Phosphonate-Based Nucleotide Analogs Related to PMEA. I. Racemic trans-Configured Derivatives." Collection of Czechoslovak Chemical Communications 61, no. 2 (1996): 313–32. http://dx.doi.org/10.1135/cccc19960313.

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Racemic trans-N-(2-phosphonomethoxycycloalkyl) derivatives of heterocyclic bases, a novel type of nucleotide analogs related to 9-(2-phosphonomethoxyethyl)adenine (PMEA), are reported. The synthesis of fully protected adenine- (5), hypoxanthine- (7), guanine- (11), thymine- (13), uracil- (16) and cytosine-containing (18) carbocyclic nucleotide analogs is based on the reaction of trans-2-hydroxycycloalkyl derivatives of N-protected nucleobases (2, 10, 12, 14, 17) with diisopropyl tosyloxymethanephosphonate. Deprotection of these compounds afforded the title nucleotide analogs. The starting nucl

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Más fuentes

Tesis sobre el tema "Thymine nucleotide"

Thompson, Nadine. "Single Nucleotide Polymorphisms in the Folypoly-gamma-glutamate synthetase Gene." VCU Scholars Compass, 2006. http://scholarscompass.vcu.edu/etd/672.

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Folic acid is an essential vitamin utilized in the one-carbon metabolism pathway for the synthesis of purine and thymidine nucleotides, which are necessary for cell growth and proliferation. As a result, the enzymes that participate in the metabolism of folic acid have been good targets for cancer chemotherapy. Folylpoly-γ-glutamate synthetase (FPGS) is an enzyme in the folate metabolism pathway that catalyzes the addition of glutamic acid to the naturally occurring folates, thereby allowing the retention of folate cofactors in cells. Similarly, in the case of cancer chemotherapy, antifolates,

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Sweetman, Sandra Frances. "An investigation of bleomycin induced DNA damage and repair in wild-type and thymidine kinase deficient human and murine cell lines." Thesis, University of Ulster, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242069.

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Kosinska, Urszula. "Salvage enzymes in nucleotide biosynthesis : structural studies on three bacterial thymidine kinases and human uridine-cytidine kinase 1 /." Uppsala : Dept. of Molecular Biology, Swedish University of Agricultural Sciences, 2007. http://epsilon.slu.se/200749.pdf.

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Turner, Stephen J. "Design and synthesis of some novel masked 5#-N-substituted thymidine nucleotides as anti-HIV agents." Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241264.

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Vodnala, Munender. "Targeting the nucleotide metabolism of the mammalian pathogen Trypanosoma brucei." Doctoral thesis, Umeå universitet, Institutionen för medicinsk kemi och biofysik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-80904.

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Trypanosoma brucei causes African sleeping sickness in humans and Nagana in cattle. There are no vaccines available against the disease and the current treatment is also not satisfactory because of inefficacy and numerous side effects of the used drugs. T. brucei lacks de novo synthesis of purine nucleosides; hence it depends on the host to make its purine nucleotides. T. brucei has a high affinity adenosine kinase (TbAK), which phosphorylates adenosine, deoxyadenosine (dAdo), inosine and their analogs. RNAi experiments confirmed that TbAK is responsible for the salvage of dAdo and the toxicit

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Sournia, Pierre. "La méthylation flavine-dépendante d’acides nucléiques : aspects évolutifs, métaboliques, biochimiques et spectroscopiques." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLX108/document.

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La méthylation de l’uridine sur son carbone 5 est apparue au cours de l’évolution sous plusieurs formes. Tout d’abord, les thymidylate synthases permettent la synthèse de novo du dTMP, un précurseur essentiel de l’ADN des trois règnes du vivant. Deux familles de thymidylate synthases sont connues à ce jour : ThyA et la flavo-enzyme ThyX, codées par des gènes hétérologues et ayant des structures et mécanismes réactionnels radicalement différents. En outre, cette méthylation de l’uridine est apparue (probablement plus tard) sous forme de modifications post-transcriptionnelles des ARNt et ARNr. C

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Jaša, Petr. "Techniky pro získávání dat v genomice." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2007. http://www.nusl.cz/ntk/nusl-412789.

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First of all, this thesis sets itself a goal to introduce some common technics for datamining in genomics and as a next step to implement own algorithm like algorithm BLAST. In the concrete, this work is pointed to sequences of DNA. The DNA sequence contains in itself genetic information, which is template for living organism. For explanation this information can be used number of technics. This paper describes algorithm Fasta and algorithms from BLAST family. With these algorithms, it is possible to gain a lot of important information even about such DNA sequences, where only primary structur

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Wheelhouse, Richard T., Terence C. Jenkins, Sharon A. Jennings, and Dimitrios Pletsas. "Design, Synthesis and Evaluation of Novel Biarylpyrimidines ¿ a New Class of Ligand for Unusual Nucleic Acid Structures." 2006. http://hdl.handle.net/10454/3150.

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No<br>Biarylpyrimidines are characterized as selective ligands for higher-order nucleic acid structures. A concise and efficient synthesis has been devised incorporating Suzuki biaryl cross-coupling of dihalopyrimidines. Two ligand series are described based on the parent thioether 4,6-bis[4-[[2-(dimethylamino)ethyl]mercapto]-phenyl]pyrimidine (la) and amide 4,6-bis(4[(2-(dimethylamino)ethyl)carboxamido]phenyl)pyrimidine (2a) compounds. In UV thermal denaturation studies with the poly(dA)·[poly(dT)]2 triplex structure, thioethers showed stabilization of the triplex form (¿Tm ¿ 20 °C). In contr

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Prahadeeswaran, D. "X-Ray Crystallographic Studies On Tosyl, Trityl Nucleosides And A 2'-Nucleotide." Thesis, 1997. http://etd.iisc.ernet.in/handle/2005/1827.

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Capítulos de libros sobre el tema "Thymine nucleotide"

Melamede, Robert J., and Susan S. Wallace. "A Possible Secondary Role for Thymine-Containing DNA Precursors." In Genetic Consequences of Nucleotide Pool Imbalance. Springer US, 1985. http://dx.doi.org/10.1007/978-1-4613-2449-2_5.

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Pero, Ronald W., Anders Olsson, and Desmond Johnsonf. "Regulation of Extracellular Thymidine Pools in Human Blood Samples." In Genetic Consequences of Nucleotide Pool Imbalance. Springer US, 1985. http://dx.doi.org/10.1007/978-1-4613-2449-2_31.

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Matheson, David S., Bridget J. Green, David I. Hoar, Susan J. Friedman, and Masafumi Inoue. "Agents which Decrease Intracellular Thymidine Pools Cause an Augmentation in Human Natural Killer Activity in vitro." In Genetic Consequences of Nucleotide Pool Imbalance. Springer US, 1985. http://dx.doi.org/10.1007/978-1-4613-2449-2_29.

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"Thymidylic Acid (nucleotide of thymine)." In Encyclopedia of Genetics, Genomics, Proteomics and Informatics. Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6754-9_16967.

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White, Perrin C. "Genes and Hormones." In Textbook of Endocrine Physiology. Oxford University Press, 2011. http://dx.doi.org/10.1093/oso/9780199744121.003.0005.

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Much of the knowledge presented in the following chapters has been gained using molecular genetic techniques to analyze the structure, synthesis, regulation, and effects of hormones. This chapter provides an overview of some of the relevant techniques and associated concepts. To allow the reader to understand older experiments, we have tried to include techniques that are now of mainly historical interest as well as current concepts. Deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) consist of nucleotides . A nucleotide consists of a base , a sugar moiety (either deoxyribose or ribose), and a phosphate group. The sugars and phosphates alternate in the backbone of a nucleic acid strand. In general, there are four possible bases. In DNA, these are adenine ( A ), cytosine ( C ), guanine ( G ), and thymine ( T ). Adenine and guanine are purines , whereas cytosine and thymine are pyrimidines . The corresponding nucleotides are adenosine , cytidine , guanosine , and thymidine. In RNA, uracil (uridine) is substituted for thymine (thymidine). DNA is double stranded. Each strand has a direction because the deoxyribose molecules forming the backbone are asymmetrical, with the phosphate bonds linking each two sugar molecules going from the 3’ position of one to the 5’ position of the next. Thus, the 5’ position of a sugar molecule is free at one end (the 5’ end) of the strand, and the 3’ position is free at the other. The two strands of a DNA molecule run in opposite directions, so that the 5’ end of one strand is opposed to the 3’ end of the complementary strand. The DNA strands interact with each other through complementary (Watson-Crick) base pairing , in which A and T, or C and G, are paired through hydrogen bonds. Thus, the sequence of one DNA strand unambiguously determines the sequence of the complementary strand during DNA replication. The length of a DNA segment is typically given in bases or nucleotides (nt) or, if double stranded, base pairs (bp).

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Watts, Richard W. E. "Disorders of purine and pyrimidine metabolism." In Oxford Textbook of Medicine. Oxford University Press, 2010. http://dx.doi.org/10.1093/med/9780199204854.003.1204.

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These disorders are due to abnormalities in the biosynthesis, interconversion and degradation of the purines—adenine and guanine—and of the pyrimidines—cytosine, thymine and uracil. All are heterocyclic bases which exist in tri-, di-, and mono-phosphorylated forms, and as either deoxyribosylated or ribosylated derivatives (deoxyribose and ribose are pentose carbohydrates). The phosphorylated deoxyribosylated and ribosylated derivatives are termed ‘nucleotides’, and the purely ribosylated derivatives, which lack the phosphate group, are ‘nucleosides’....

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Marinaki, Anthony M., Lynette D. Fairbanks, and Richard W. E. Watts. "Disorders of purine and pyrimidine metabolism." In Oxford Textbook of Medicine, edited by Timothy M. Cox. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198746690.003.0230.

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Disorders of purine and pyrimidine metabolism are due to abnormalities in the biosynthesis, interconversion, and degradation of the purines—adenine and guanine—and of the pyrimidines—cytosine, thymine, and uracil. The purine nucleotides, their cyclic derivatives (cAMP and cGMP), and their more highly phosphorylated derivatives have functions in many aspects of intermediary metabolism. Purine compounds also function as signal transducers, neurotransmitters, vasodilators, and mediators of platelet aggregation. Disorders of purine metabolism—the end point of purine metabolism in humans is uric acid. When uric acid levels become supersaturated in body fluids, uric acid and sodium urate monohydrate crystallize, causing gout. This results from either overproduction or underexcretion of urate, or from a combination of these defects. Decreased net tubular urate secretion is most often due to genetic polymorphism in uric acid transporters and is the commonest cause of primary (‘idiopathic’) gout. Gout may be secondary to a wide variety of renal disorders. Gout is also a consequence of enzymatic defects that accelerate de novo purine synthesis. Acute attacks of gout are treated with nonsteroidal anti-inflammatory drugs, colchicine, or steroids. Hypouricaemia may be caused by inherited disorders of uric acid biosynthesis or may be due to inherited or acquired renal tubule transport defects. Disorders of pyrimidine metabolism—the de novo synthesis of pyrimidine nucleotides involves a series of six reactions beginning with the formation of carbamyl phosphate and concluding with orotidine monophosphate, which then undergoes a series of interconversion and salvage reactions. The inherited disorders of pyrimidine metabolism, which can present in a wide variety of ways, are much less common and/or much less easily recognized than disorders of purine metabolism.

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Pan, Xinghua, Alexander Urban, and Sherman Weissman. "Enriching DNA Sequences with Nucleotide Variation by Thymidine Glycosylases Combined with Suppression PCR." In PCR Technology. CRC Press, 2013. http://dx.doi.org/10.1201/b14930-27.

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Actas de conferencias sobre el tema "Thymine nucleotide"

Zolotoukhina, Tatiana, and Takeo Fukui. "Identification of Nucleobases of Single Stranded DNA by Nanopore Force Resolution at Different Film Thickness." In ASME/JSME 2011 8th Thermal Engineering Joint Conference. ASMEDC, 2011. http://dx.doi.org/10.1115/ajtec2011-44260.

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The model of the molecular translocation of all types of DNA base molecules of cytosine, thymine, adenine and guanine through the nanoporous membrane of a solid thin film has been considered from the point of view of improving the resolution of forces by changing parameters of the membrane itself. The results of simulation of translocation process were compared for all four DNA nucleotides. The molecular dynamics (MD) method with the force field potential has been used for the atomic level modeling of the cytosine (C), thymine (T), adenine (A), and guanine (G) molecules and a configuration of

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Kitamura, Ayano, Marina Komatsu, Yoshimichi Ohki, Maya Mizuno, Miki Hirabayashi, and Hiroaki Kojima. "Estimation of the number of nucleotides with thymine in deoxyribonucleic acid by far-infrared absorption." In 2015 IEEE Conference on Electrical Insulation and Dielectric Phenomena - (CEIDP). IEEE, 2015. http://dx.doi.org/10.1109/ceidp.2015.7351989.

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Berardi, Rossana, Silvia Pagliaretta, Alessandro Brunelli, et al. "Abstract 2220: Impact of single-nucleotide polymorphisms (SNPs) on thymic hyperplasia and tumors outcome." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-2220.

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