Bibliografías temáticas / Thymine – Reactivity

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Literatura académica sobre el tema "Thymine – Reactivity"

Autor: Grafiati
Publicado: 4 de junio de 2021
Última modificación: 14 de febrero de 2022

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Artículos de revistas sobre el tema "Thymine – Reactivity"

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Kanvah, Sriram y Gary B. Schuster. "One-electron oxidation of DNA: thymine versus guanine reactivity". Organic & Biomolecular Chemistry 8, n.º 6 (2010): 1340. http://dx.doi.org/10.1039/b922881k.

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Farooqui, Huma, Amarjeet Yadav y B. K. Pandey. "Hydroxyl Radical Reactivity with Cytosine and Thymine: A Computational Study". Journal of Physics: Conference Series 1849, n.º 1 (1 de marzo de 2021): 012029. http://dx.doi.org/10.1088/1742-6596/1849/1/012029.

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Nomura, A. y A. Okamoto. "Reactivity of Thymine Doublet in Single Strand DNA with Osmium Reagent". Nucleic Acids Symposium Series 52, n.º 1 (1 de septiembre de 2008): 433–34. http://dx.doi.org/10.1093/nass/nrn220.

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Wrigstedt, Pauli, Jari Kavakka, Sami Heikkinen, Martin Nieger, Minna Räisänen y Timo Repo. "The Reactivity of Thymine and Thymidine 5,6-Epoxides with Organometallic Reagents – A Route to Thymidine (6-4) Photoproduct Analogues". Journal of Organic Chemistry 81, n.º 9 (22 de abril de 2016): 3848–59. http://dx.doi.org/10.1021/acs.joc.6b00495.

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Tan, Rongri, Dongqi Wang, Lin Hu y Feng-Shou Zhang. "Probing the Reactivity of Hydroxyl Radicals toward Isolated Thymine Using Theoretical Calculations". International Journal of Quantum Chemistry 114, n.º 6 (10 de octubre de 2013): 367–74. http://dx.doi.org/10.1002/qua.24567.

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Nikolova, Valya y Boris Galabov. "Effects of structural variations on the hydrogen bond pairing between adenine derivatives and thymine". Macedonian Journal of Chemistry and Chemical Engineering 34, n.º 1 (26 de marzo de 2015): 159. http://dx.doi.org/10.20450/mjcce.2015.644.

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<p><strong>Abstract:</strong><strong> </strong>The hydrogen bonding between substituted adenines and thymine was investigated by density functional theory computations at the B3LYP/6-311+G(2d,2p) level. The effect of 20 different polar substituents at position 8 in adenine was examined in detail. Three different theoretical parameters, reflecting the electrostatics at the atoms involved in hydrogen bonding, were applied. An excellent correlation between electrostatic potentials at the bonding atoms in the monomer adenines and interaction energies was derived (Eqn. 2). It can be employed in designing bioactive adenine derivatives that are able to bind with a finely adjusted strength to thymine bioreceptor sites. NBO and Hirshfeld atomic charges are found to be less successful as reactivity predictors in these interactions.</p>
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Jumpathong, Watthanachai, Wan Chan, Koli Taghizadeh, I. Ramesh Babu y Peter C. Dedon. "Metabolic fate of endogenous molecular damage: Urinary glutathione conjugates of DNA-derived base propenals as markers of inflammation". Proceedings of the National Academy of Sciences 112, n.º 35 (17 de agosto de 2015): E4845—E4853. http://dx.doi.org/10.1073/pnas.1503945112.

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Although mechanistically linked to disease, cellular molecules damaged by endogenous processes have not emerged as significant biomarkers of inflammation and disease risk, due in part to poor understanding of their pharmacokinetic fate from tissue to excretion. Here, we use systematic metabolite profiling to define the fate of a common DNA oxidation product, base propenals, to discover such a biomarker. Based on known chemical reactivity and metabolism in liver cell extracts, 15 candidate metabolites were identified for liquid chromatography-coupled tandem mass spectrometry (LC-MS/MS) quantification in urine and bile of rats treated with thymine propenal (Tp). Analysis of urine revealed three metabolites (6% of Tp dose): thymine propenoate and two mercapturate derivatives of glutathione conjugates. Bile contained an additional four metabolites (22% of Tp dose): cysteinylglycine and cysteine derivatives of glutathione adducts. A bis-mercapturate was observed in urine of untreated rats and increased approximately three- to fourfold following CCl4-induced oxidative stress or treatment with the DNA-cleaving antitumor agent, bleomycin. Systematic metabolite profiling thus provides evidence for a metabolized DNA damage product as a candidate biomarker of inflammation and oxidative stress in humans.
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Li, Lei. "Using Organic Synthesis and Chemical Analysis to Understand the Photochemistry of Spore Photoproduct and Other Pyrimidine Dimers". Synlett 29, n.º 01 (30 de noviembre de 2017): 15–33. http://dx.doi.org/10.1055/s-0036-1590981.

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Pyrimidine dimerization is the dominant DNA photoreaction occurring in vitro and in vivo. Three types of dimers, cyclobutane pyrimidine dimers (CPDs), pyrimidine (6-4) pyrimidone photoproducts (6-4PPs), and the spore photoproduct (SP), are formed from the direct dimerization process; it is of significance to understand the photochemistry and photobiology of these dimers. Traditionally, pyrimidine dimerization was studied by using the natural pyrimidine residues thymine and cytosine, which share similar chemical structures and similar reactivity, making it sometimes less straightforward for one to identify the key pyrimidine residue that needs to be excited to trigger the photoreaction. We thus adopted synthetic chemistry to selectively modify the pyrimidine residues or to introduce pyrimidine analogs to the selected positions before UV irradiation is applied. By monitoring the subsequent outcomes from the photoreaction, we were able to gain unique mechanistic insights into the photochemistry of SP as well as of CPDs and 6-4PPs. Moreover, our approaches have resulted in several useful “tools” that can facilitate the understanding of lesion photobiology. Our results summarized in this account illustrate what organic synthesis/chemical analysis may allow us to achieve in future DNA lesion biology studies. 1 Introduction 2 Using the Deuterium Labeling Strategy to Understand SP Formation 3 Using Microcrystals to Reveal the Reaction Intermediates in SP Formation 4 Using a Phosphate Isostere to Understand the SP Structure 5 Synthesis of SP Phosphoramidite and SP Structural Studies 6 Using a Thymine Isostere to Understand CPD Formation 7 Using a Thymine Isostere to Understand 6-4PP Photoreaction 8 Understanding the Chemical Stability of SP 9 Understanding the Chemical Stability of 6-4PP10 Summary and Perspectives for Future Research
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Endová, Magdalena, Milena Masojídková, Miloš Buděšínský y Ivan Rosenberg. "3′,5′-O-Phosphonoalkylidene derivatives of 1-(2-deoxy-β-D-threo-pentofuranosyl)thymine: Synthesis and reactivity". Tetrahedron 54, n.º 37 (septiembre de 1998): 11187–208. http://dx.doi.org/10.1016/s0040-4020(98)00654-1.

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Ford, George P. y John D. Scribner. "Prediction of nucleoside-carcinogen reactivity. Alkylation of adenine, cytosine, guanine, and thymine and their deoxynucleosides by alkanediazonium ions". Chemical Research in Toxicology 3, n.º 3 (mayo de 1990): 219–30. http://dx.doi.org/10.1021/tx00015a006.

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Tesis sobre el tema "Thymine – Reactivity"

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SAKELLARIOU, FARGUES REINE. "Reactivite chimique et photochimique d'alpha -enones dans les milieux organises". Toulouse 3, 1986. http://www.theses.fr/1986TOU30044.

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Dans une premiere partie on determine les zones monophasiques des diagrammes des phases pseudoternaires de plusieurs microemulsions. Dans l'une d'elles l'isophorone remplace l'huile. Ensuite les chapitres ii et iii sont consacres aux reactions de photocycloaddition (a+a, a+b) d'alpha -enones (isophorone, coumarine, dimethylthymine). On montre que les phenomenes observes sont lies aux differentes localisations possibles des substrats, aux mecanismes de reaction et aux structures des milieux. En conclusion, la localisation des reactifs a l'interface permet la combinaison des effets de concentration, d'organisation et de proximite et conduit a des rendements, des regio et des stereoselectivite eleves
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Zhou, Guangwen. "Stabilization of Z-DNA by demethylation of thymine bases : a crystallization and thermo-dynamic study of d(m⁵CGUAm⁵CG)". Thesis, 1991. http://hdl.handle.net/1957/37229.

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Libros sobre el tema "Thymine – Reactivity"

1

Zhou, Guangwen. Stabilization of Z-DNA by demethylation of thymine bases: A crystallization and thermo-dynamic study of d(m⁵CGUAm⁵CG). 1991.

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Zhou, Guangwen. Stabilization of Z-DNA by demethylation of thymine bases: A crystallization and thermo-dynamic study of d(m⁵CGUAm⁵CG). 1991.

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Wallace, Valerie Anne. The involvement of cell surface glycoproteins CD4 and CD5 in T cell reactivity and thymic selection. 1993.

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Capítulos de libros sobre el tema "Thymine – Reactivity"

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Sakaguchi, Shimon, Shohei Hori, Yoshinori Fukui, Takehiko Sasazuki, Noriko Sakaguchi y Takeshi Takahashi. "Thymic Generation and Selection of CD25+ CD4+ Regulatory T Cells: Implications of Their Broad Repertoire and High Self-Reactivity for the Maintenance of Immunological Self-Tolerance". En Novartis Foundation Symposia, 6–23. Chichester, UK: John Wiley & Sons, Ltd, 2008. http://dx.doi.org/10.1002/0470871628.ch2.

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Actas de conferencias sobre el tema "Thymine – Reactivity"

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Norden, C., H. Heine, F. Misselwitz, H.-J. Herrmann, E. Engler y G. Martin. "PLATELET AND VESSEL WALL REACTIVITY IN HYPERTENSIVE AND N0RM0TENSIVE RHESUS MONKEYS". En XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644497.

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Hypertension is an important risk factor in the pathogenesis of arteriosclerosis and its thrombotic complications. Therefore, we investigated platelet and vessel wall reactivity in 7 subhuman primates (7.0 Macaca mulatta). Five monkeys received a psychosocial stress over a long-term period, three developed a stress-induced hypertension. Two unstressed normotensive monkeys served as e control. Platelet turnover in vivo, synthesis of platelet prostanoids, and various platelet function tests in vitro were determined. Vessel wall reactivity was assessed histo-pathologically and by means of H-thymidin-incorpora-tion into vessel segments in vitro. In the hypertensive rhesus monkeys an accelerated platelet turnover, accompanied with a decreased platelet count, and a markedly increased plasma-TXB2-level were found. ADP-induced platelet aggregation was slightly enhanced. Additionally, platelet adhesion to collagen-coated surfaces was investigated. We found the platelet attachment, spreading, and the formation of platelet mural thrombi to be significantly enhanced in the hypertensive animals. Histopathological examination of large arteries revealed signs of an increased intra-vital vasocontraction as well as enlargement of the relative vessel wall cross-section area in the hypertensive rhesus monkeys. Autoradiographical determination of the thymidine-incorporation in vitro allows investigation of cell proliferation in the intima and media of vessels. We found hypertension-related alterations of the media not only in large, but also in small vessels. Additionally, primary cultures of aortic endothelial cells were established and concentration of endothelial cell-specific metabolites was measured in the conditioned media. Our results confirm the existence of hypertension-related changes in platelet and vessel wall reactivity.
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