Literatura académica sobre el tema "Toxicometric parameters"

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Artículos de revistas sobre el tema "Toxicometric parameters"

1

Antonenko, A.M., O.P. Vavrinevych, S.T. Omelchuk, and B.I. Shpak. "Hygienic substantiation of calculating models for predicting toxicity of different classes insecticides (first part)." Medicni perspektivi 24, no. 3 (2019): 106–12. https://doi.org/10.26641/2307-0404.2019.3.181892.

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This work is the first part of our study to develop alternative experimental mathematic models for predicting toxicity of insecticides. In the first stage, calculations will be carried out and the most reliable models will be proposed. In the second – a statistical analysis and comparative estimation of the toxicometric parameters obtained experimentally and calculated according to the proposed equations. The purpose of the research is the scientific substantiation of the calculation models for predicting toxicity of insecticides of different classes. Data on the physico-chemical propert
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2

Komarova, E. F., E. V. Verenikina, N. A. Shevchenko, et al. "EVALUATION OF TOXICOMETRIC PARAMETERS OF BENZIMIDAZOLE DERIVATIVE FOR LINEAR MICE C57/BL6." Современные проблемы науки и образования (Modern Problems of Science and Education), no. 2 2023 (2023): 47. http://dx.doi.org/10.17513/spno.32499.

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Vavrinevych, O.P., B.I. Shpak, A.M. Antonenko, S.T. Omelchuk, and T.I. Zinchenko. "Hygienic substantiation of calculating models for prognosis of toxicity of different classes insecticides (second part)." Medicni perspektivi 25, no. 4 (2020): 166–73. https://doi.org/10.26641/2307-0404.2020.4.221663.

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This work is the second part of our study to develop alternative experimental mathematic models for predecting toxicity of insecticides, where we carried out a statistical analysis and comparative estimation of the toxicometric parameters obtained experimentally and calculated according to the proposed equations. In the first stage calculations were carried out and the most reliable models were proposed. The purpose of the research is the scientific substantiation and statistical analysis of the calculation models for predicting the toxicity of insecticides of different classes. For research w
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4

Epishina, Tatiana M. "Comparative studies of the toxicity of new synthetic detergents based on anionic and nonionic surface active substance." Toxicological Review 32, no. 5 (2024): 301–6. http://dx.doi.org/10.47470/0869-7922-2024-32-5-301-306.

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Introduction. Among the complex of environmental factors that are subject to toxicological and hygienic studies, household chemicals deserve great attention due to their mass production, a variety of components and formulations, as well as possible direct effects on the human body. The purpose of the work is to conduct comparative studies on the study of toxicometric parameters of new synthetic detergents. Material and methods. In accordance with the planned purpose of the study in the biological testing laboratory of the “Federal Scientific Center of Hygiene named after F.F. Erisman”, experim
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5

Novikova, O. N., E. S. Matyugina, A. V. Gorshenin, et al. "5'-Noraristeromycin Repurposing: Well-known S-Adenosyl-L-homocysteine Hydrolase Inhibitor As a Potential Drug Against Leukemia." Acta Naturae 16, no. 3 (2024): 60–66. http://dx.doi.org/10.32607/actanaturae.27443.

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5ˊ-Noraristeromycin as a racemic mixture of enantiomers was found to exhibit a pronounced cytotoxic effect on leukemia cells; IC50 for the Jurkat, K562, and THP-1 cell lines was 7.3, 1.3, and 3.7 μM, respectively. The general toxicity of 5'-noraristeromycin was studied in experiments on white mice upon single-dose intragastric administration; toxicometric parameters were determined, and the clinical and pathomorphological presentation of acute intoxication was studied. LD50 of the substance was shown to be 63.2 (52.7÷75.8) mg/kg; LD16, 44.7 mg/kg, and LD84, 89.4 mg/kg. Administration of the su
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6

Głowacki, Arkadiusz, Przemysław Rybiński, Monika Żelezik, and Ulugbek Zakirovich Mirkhodjaev. "Cage Nanofillers’ Influence on Fire Hazard and Toxic Gases Emitted during Thermal Decomposition of Polyurethane Foam." Polymers 16, no. 5 (2024): 645. http://dx.doi.org/10.3390/polym16050645.

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Polyurethane (PUR), as an engineering polymer, is widely used in many sectors of industries. However, the high fire risks associated with PUR, including the smoke density, a high heat release rate, and the toxicity of combustion products limit its applications in many fields. This paper presents the influence of silsesquioxane fillers, alone and in a synergistic system with halogen-free flame-retardant compounds, on reducing the fire hazard of polyurethane foams. The flammability of PUR composites was determined with the use of a pyrolysis combustion flow calorimeter (PCFC) and a cone calorime
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7

Khalilov, Laziz, and Yunus Salimov. "PARAMETERS OF ACUTE TOXICITY AND TOXIC EFFECTS OF THE SYNTHETIC PYRETHROID ASHIMETHRIN ALPHA ON THE ANIMAL BODY." INTERNATIONAL JOURNAL OF SCIENCE AND TECHNOLOGY 2, no. 05 (2025): 87–89. https://doi.org/10.70728/tech.v2.i05.030.

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The article presents the results of studying the acute toxicity of the synthetic pyrethroid ashimethrin alpha (Achich Life Science Put.Ltd., India) on the body of rabbits and Karakul sheep. To determine the main toxicometric parameters, experimental rabbits were given ashimethrin alpha orally once in the form of a 10% suspension at doses of 1300, 1375, 1450, 1525 and 1600 mg / kg, and Karakul sheep received doses of 200, 275, and 350 mg/kg (based on the active ingredient). Studies have established that LD50 for rabbits is 1450.00 mg/kg, and for sheep 347.79 mg/kg. Our observations showed that
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8

Antonova, O. M. "Promising approaches to assessing the public health risk with real ways of entering a toxicant into the body." Povolzhskiy Journal of Ecology, no. 4 (June 11, 2022): 371–84. http://dx.doi.org/10.35885/1684-7318-2021-4-371-384.

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The paper discusses promising directions of scientific and technological development of the Russian Federation in the field of ecology and nature management, and related problems and solutions for assessing the public health risk. The prospects of creating methods for rapid assessment of public health risk using modern data and representations of toxicokinetics and toxicodynamics of the substance are substantiated. It is shown that it is possible to deduce adequate mathematical dependencies for substances regardless of their structure, based on modern concepts of the formation of the dose of a
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9

Andreev, V. A., E. Yu Andreeva, L. P. Erdniyev, et al. "Using the Paramecium caudatum test object to determine acute toxicity of physiologically active substances." Bulletin of the Russian Military Medical Academy 21, no. 2 (2019): 110–13. http://dx.doi.org/10.17816/brmma25929.

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The advantage of biotesting in comparison with the physicochemical analysis of the use of Paramecium caudatum for toxicological studies has been shown. Physical and chemical analysis often fails to detect unstable compounds. In addition, these tools are not possible to determine the ultra-low concentration of chemicals. In addition to the traditional use of laboratory animals, representatives of protozoa have recently been used. In connection with this, a test object of the Sim-plest type was chosen and justified. The advantages of using the simplest compared with the use of laboratory animals
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10

Vostroilova, G. A., N. A. Khokhlova, Y. A. Chaplygina, and M. S. Bogdanova. "SAFETY ASSESSMENT OF THE NEW DRUG "MT-6" IN AN ACUTE EXPERIMENT ON WHITE MICE." Scientific Life 15, no. 5 (2020): 700–707. http://dx.doi.org/10.35679/1991-9476-2020-15-5-700-707.

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The article presents the results of assessing the safety of the new drug "MT-6" in an acute experiment on white mice. Experiments to assess acute toxicity were carried out in three series of experiments with intragastric, subcutaneous and intramuscular routes of administration in duplicate. The drug was administered intragastrically once after a 12-hour fasting diet in doses from 5500 to 10000 mg/kg in a volume of 0.5 ml per mouse; subcutaneously – in the dose range from 2000 to 6800 mg/kg in a volume of 0.5 ml per mouse; intramuscularly – in doses from 2000 to 6800 mg/kg in a volume of 0.25 m
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