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1

Geurts, Dirk E. M., Quentin J. M. Huys, Hanneke E. M. den Ouden, and Roshan Cools. "Aversive Pavlovian Control of Instrumental Behavior in Humans." Journal of Cognitive Neuroscience 25, no. 9 (2013): 1428–41. http://dx.doi.org/10.1162/jocn_a_00425.

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Adaptive behavior involves interactions between systems regulating Pavlovian and instrumental control of actions. Here, we present the first investigation of the neural mechanisms underlying aversive Pavlovian–instrumental transfer using fMRI in humans. Recent evidence indicates that these Pavlovian influences on instrumental actions are action-specific: Instrumental approach is invigorated by appetitive Pavlovian cues but inhibited by aversive Pavlovian cues. Conversely, instrumental withdrawal is inhibited by appetitive Pavlovian cues but invigorated by aversive Pavlovian cues. We show that
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2

Talmi, D., B. Seymour, P. Dayan, and R. J. Dolan. "Human Pavlovian Instrumental Transfer." Journal of Neuroscience 28, no. 2 (2008): 360–68. http://dx.doi.org/10.1523/jneurosci.4028-07.2008.

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3

Peng, Ziwen, Luning He, Rongzhen Wen, Tom Verguts, Carol A. Seger, and Qi Chen. "Obsessive-compulsive disorder is characterized by decreased Pavlovian influence on instrumental behavior." PLOS Computational Biology 18, no. 10 (2022): e1009945. http://dx.doi.org/10.1371/journal.pcbi.1009945.

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Obsessive-compulsive disorder (OCD) is characterized by uncontrollable repetitive actions thought to rely on abnormalities within fundamental instrumental learning systems. We investigated cognitive and computational mechanisms underlying Pavlovian biases on instrumental behavior in both clinical OCD patients and healthy controls using a Pavlovian-Instrumental Transfer (PIT) task. PIT is typically evidenced by increased responding in the presence of a positive (previously rewarded) Pavlovian cue, and reduced responding in the presence of a negative cue. Thirty OCD patients and thirty-one healt
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4

Xu, Yanwei. "Instrumental Behavior in Pavlovian-instrumental Transfer for Depression Therapy." Communications in Humanities Research 56, no. 1 (2025): 24–30. https://doi.org/10.54254/2753-7064/2024.21058.

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The mental condition is closely linked with peoples instrumental behavior, which allows us to adapt to the external environment. Rely on the positive valence system, the habits and goal or value seeking behavior is linked with the instrumental behavior and the influence of environmental cues. While depression patients build up an aversive Pavlovian-instrumental transfer and form a biased emotional state. The Pavlovian-to-instrumental transfer (PIT) was influenced by the environment and was reflected in biological chemistry level. Also, in the safety learning and exposure therapy, instrumental
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5

Quail, Stephanie L., Vincent Laurent, and Bernard W. Balleine. "Inhibitory Pavlovian–instrumental transfer in humans." Journal of Experimental Psychology: Animal Learning and Cognition 43, no. 4 (2017): 315–24. http://dx.doi.org/10.1037/xan0000148.

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6

Cartoni, Emilio, Bernard Balleine, and Gianluca Baldassarre. "Appetitive Pavlovian-instrumental Transfer: A review." Neuroscience & Biobehavioral Reviews 71 (December 2016): 829–48. http://dx.doi.org/10.1016/j.neubiorev.2016.09.020.

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7

Cohen-Hatton, Sabrina R., Josephine E. Haddon, David N. George, and R. C. Honey. "Pavlovian-to-instrumental transfer: Paradoxical effects of the Pavlovian relationship explained." Journal of Experimental Psychology: Animal Behavior Processes 39, no. 1 (2013): 14–23. http://dx.doi.org/10.1037/a0030594.

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8

Lewis, Andrea H., Michael A. Niznikiewicz, Andrew R. Delamater, and Mauricio R. Delgado. "Avoidance-based human Pavlovian-to-instrumental transfer." European Journal of Neuroscience 38, no. 12 (2013): 3740–48. http://dx.doi.org/10.1111/ejn.12377.

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9

Seabrooke, Tina, Lee Hogarth, C. E. R. Edmunds, and Chris J. Mitchell. "Goal-directed control in Pavlovian-instrumental transfer." Journal of Experimental Psychology: Animal Learning and Cognition 45, no. 1 (2019): 95–101. http://dx.doi.org/10.1037/xan0000191.

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10

Matell, Matthew S., and Rebecca B. Della Valle. "Temporal specificity in Pavlovian-to-instrumental transfer." Learning & Memory 25, no. 1 (2017): 8–20. http://dx.doi.org/10.1101/lm.046383.117.

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11

Campese, Vinn D., Ian T. Kim, Botagoz Kurpas, Lauren Branigan, Cassandra Draus, and Joseph E. LeDoux. "Motivational factors underlying aversive Pavlovian-instrumental transfer." Learning & Memory 27, no. 11 (2020): 477–82. http://dx.doi.org/10.1101/lm.052316.120.

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12

Holmes, Nathan M., Alain R. Marchand, and Etienne Coutureau. "Pavlovian to instrumental transfer: A neurobehavioural perspective." Neuroscience & Biobehavioral Reviews 34, no. 8 (2010): 1277–95. http://dx.doi.org/10.1016/j.neubiorev.2010.03.007.

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13

Sebold, Miriam, Daniel J. Schad, Stephan Nebe, et al. "Don't Think, Just Feel the Music: Individuals with Strong Pavlovian-to-Instrumental Transfer Effects Rely Less on Model-based Reinforcement Learning." Journal of Cognitive Neuroscience 28, no. 7 (2016): 985–95. http://dx.doi.org/10.1162/jocn_a_00945.

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Behavioral choice can be characterized along two axes. One axis distinguishes reflexive, model-free systems that slowly accumulate values through experience and a model-based system that uses knowledge to reason prospectively. The second axis distinguishes Pavlovian valuation of stimuli from instrumental valuation of actions or stimulus–action pairs. This results in four values and many possible interactions between them, with important consequences for accounts of individual variation. We here explored whether individual variation along one axis was related to individual variation along the o
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14

Davidson, T. L., Juan Aparicio, and Robert A. Rescorla. "Transfer between Pavlovian facilitators and instrumental discriminative stimuli." Animal Learning & Behavior 16, no. 3 (1988): 285–91. http://dx.doi.org/10.3758/bf03209078.

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15

LeBlanc, Kimberly H., Sean B. Ostlund, and Nigel T. Maidment. "Pavlovian-to-instrumental transfer in cocaine seeking rats." Behavioral Neuroscience 126, no. 5 (2012): 681–89. http://dx.doi.org/10.1037/a0029534.

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16

Xia, Yanfang, Angelina Gurkina, and Dominik R. Bach. "Pavlovian-to-instrumental transfer after human threat conditioning." Learning & Memory 26, no. 5 (2019): 167–75. http://dx.doi.org/10.1101/lm.049338.119.

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17

Corbit, Laura H., and Patricia H. Janak. "Ethanol-Associated Cues Produce General Pavlovian-Instrumental Transfer." Alcoholism: Clinical and Experimental Research 31, no. 5 (2007): 766–74. http://dx.doi.org/10.1111/j.1530-0277.2007.00359.x.

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18

Holland, Peter C. "Relations Between Pavlovian-Instrumental Transfer and Reinforcer Devaluation." Journal of Experimental Psychology: Animal Behavior Processes 30, no. 2 (2004): 104–17. http://dx.doi.org/10.1037/0097-7403.30.2.104.

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19

Laurent, Vincent, Progya Priya, Byron E. Crimmins, and Bernard W. Balleine. "General Pavlovian-instrumental transfer tests reveal selective inhibition of the response type – whether Pavlovian or instrumental – performed during extinction." Neurobiology of Learning and Memory 183 (September 2021): 107483. http://dx.doi.org/10.1016/j.nlm.2021.107483.

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20

Pielock, Steffi M., Susanne Sommer, and Wolfgang Hauber. "Post-training glucocorticoid receptor activation during Pavlovian conditioning reduces Pavlovian-instrumental transfer in rats." Pharmacology Biochemistry and Behavior 104 (March 2013): 125–31. http://dx.doi.org/10.1016/j.pbb.2012.12.017.

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21

Jeffs, Stephens, and Theodora Duka. "Predictive but not emotional value of Pavlovian stimuli leads to pavlovian-to-instrumental transfer." Behavioural Brain Research 321 (March 2017): 214–22. http://dx.doi.org/10.1016/j.bbr.2016.12.022.

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22

Sommer, Susanne, Alexandra Münster, Jean-Alain Fehrentz, and Wolfgang Hauber. "Effects of Motivational Downshifts on Specific Pavlovian-Instrumental Transfer in Rats." International Journal of Neuropsychopharmacology 25, no. 3 (2022): 173–84. http://dx.doi.org/10.1093/ijnp/pyab075.

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Abstract Background Pavlovian stimuli predictive of appetitive outcomes can exert a powerful influence on the selection and initiation of action, a phenomenon termed outcome-selective Pavlovian-instrumental transfer (sPIT). Rodent studies suggest that sPIT is insensitive to motivational downshift induced by outcome devaluation, an effect that is, however, relatively underexplored. Methods Here we examined in detail the effects of distinct shifts in motivation from hunger to a state of relative satiety on sPIT in rats. Results A motivational downshift by outcome-specific devaluation immediately
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23

Jeffs, Stephen, and Theodora Duka. "Single-response appetitive Pavlovian to instrumental transfer is suppressed by aversive counter-conditioning." Quarterly Journal of Experimental Psychology 72, no. 12 (2019): 2820–32. http://dx.doi.org/10.1177/1747021819862996.

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Environmental stimuli, when paired with reward, can influence behaviour in maladaptive ways, for example, by encouraging overeating or addiction. Such behaviour can be sensitive to reward value manipulations, under circumscribed conditions, but whether reward-seeking is also sensitive to stimulus value manipulations remains unclear. Thus, the current experiment investigated whether reducing the hedonic value of a reward-paired stimulus would reduce reward-seeking behaviour. In total, 36 participants successfully completed a single-response Pavlovian-instrumental transfer (PIT) task with a coun
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24

Campese, Vincent D. "The lesser evil: Pavlovian-instrumental transfer & aversive motivation." Behavioural Brain Research 412 (August 2021): 113431. http://dx.doi.org/10.1016/j.bbr.2021.113431.

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25

Krypotos, Angelos-Miltiadis, and Iris M. Engelhard. "Pavlovian-to-instrumental transfer in subclinical obsessive–compulsive disorder." Journal of Experimental Psychopathology 11, no. 3 (2020): 204380872092524. http://dx.doi.org/10.1177/2043808720925244.

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Pavlovian-to-instrumental transfer (PIT) refers to the effect of stimuli that have been associated with a pleasant or aversive event on instrumental behaviors. Given that obsessive–compulsive disorder (OCD) is linked to excessive compulsions, which in the laboratory can be tested via testing instrumental responses, we assessed PIT effects in individuals with subclinical levels of OCD. Participants from a nonclinical population were separated in groups with low (OC−) and high (OC+) levels of OCD. Participants learned to associate one button press ( R1) with the cancellation of an aversive outco
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26

Mahlberg, Justin, Gabrielle Weidemann, Lee Hogarth, and Ahmed A. Moustafa. "Cue-elicited craving and human Pavlovian-to-instrumental transfer." Addiction Research & Theory 27, no. 6 (2019): 482–88. http://dx.doi.org/10.1080/16066359.2018.1544625.

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27

Trick, Leanne, Lee Hogarth, and Theodora Duka. "Prediction and uncertainty in human Pavlovian to instrumental transfer." Journal of Experimental Psychology: Learning, Memory, and Cognition 37, no. 3 (2011): 757–65. http://dx.doi.org/10.1037/a0022310.

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28

Lee, J. L. C., and B. J. Everitt. "Reactivation-dependent amnesia in Pavlovian approach and instrumental transfer." Learning & Memory 15, no. 8 (2008): 597–602. http://dx.doi.org/10.1101/lm.1029808.

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29

Quail, Stephanie L., Richard W. Morris, and Bernard W. Balleine. "Stress associated changes in Pavlovian-instrumental transfer in humans." Quarterly Journal of Experimental Psychology 70, no. 4 (2017): 675–85. http://dx.doi.org/10.1080/17470218.2016.1149198.

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30

Hall, Darien A., and Joshua M. Gulley. "Disruptive effect of amphetamines on Pavlovian to instrumental transfer." Behavioural Brain Research 216, no. 1 (2011): 440–45. http://dx.doi.org/10.1016/j.bbr.2010.08.040.

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31

Seabrooke, Tina, Mike E. Le Pelley, Alexis Porter, and Chris J. Mitchell. "Extinguishing cue-controlled reward choice: Effects of Pavlovian extinction on outcome-selective Pavlovian-instrumental transfer." Journal of Experimental Psychology: Animal Learning and Cognition 44, no. 3 (2018): 280–92. http://dx.doi.org/10.1037/xan0000176.

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32

Heinz, Andreas, Anne Beck, Melissa Gül Halil, Maximilian Pilhatsch, Michael N. Smolka, and Shuyan Liu. "Addiction as Learned Behavior Patterns." Journal of Clinical Medicine 8, no. 8 (2019): 1086. http://dx.doi.org/10.3390/jcm8081086.

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Individuals with substance use disorders (SUDs) have to cope with drug-related cues and contexts which can affect instrumental drug seeking, as shown with Pavlovian-to-instrumental transfer (PIT) tasks among humans and animals. Our review addresses two potential mechanisms that may contribute to habitual or even compulsive drug seeking and taking. One mechanism is represented by Pavlovian and PIT effects on drug intake. The other is a shift from goal-directed to habitual drug intake, which can be accessed via model-based versus model-free decision-making in respective learning tasks. We discus
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33

Ostlund, Sean B., and Andrew T. Marshall. "Probing the role of reward expectancy in Pavlovian-instrumental transfer." Current Opinion in Behavioral Sciences 41 (October 2021): 106–13. http://dx.doi.org/10.1016/j.cobeha.2021.04.021.

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34

Garbusow, Maria, Daniel J. Schad, Christian Sommer, et al. "Pavlovian-to-Instrumental Transfer in Alcohol Dependence: A Pilot Study." Neuropsychobiology 70, no. 2 (2014): 111–21. http://dx.doi.org/10.1159/000363507.

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35

Huys, Q. J. M., M. Gölzer, E. Friedel, et al. "The specificity of Pavlovian regulation is associated with recovery from depression." Psychological Medicine 46, no. 5 (2016): 1027–35. http://dx.doi.org/10.1017/s0033291715002597.

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BackgroundChanges in reflexive emotional responses are hallmarks of depression, but how emotional reflexes make an impact on adaptive decision-making in depression has not been examined formally. Using a Pavlovian-instrumental transfer (PIT) task, we compared the influence of affectively valenced stimuli on decision-making in depression and generalized anxiety disorder compared with healthy controls; and related this to the longitudinal course of the illness.MethodA total of 40 subjects with a current DSM-IV-TR diagnosis of major depressive disorder, dysthymia, generalized anxiety disorder, or
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36

Wells, Timothy J., Lucie Krejčová, Jakub Binter, James G. Pfaus, and Rachel R. Horsley. "No significant effect of frequent online sexual behaviour on Pavlovian-to-instrumental transfer (PIT): Implications for compulsive sexual behaviour disorder." PLOS ONE 17, no. 9 (2022): e0274913. http://dx.doi.org/10.1371/journal.pone.0274913.

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Reward based learning is broadly acknowledged to underpin the development and maintenance of addictive behaviour although the mechanism in sexual compulsivity is less understood. Using a Pavlovian-to-Instrumental Transfer (PIT) task we tested whether the motivational aspect of conditioned Pavlovian conditioned stimulus invigorated instrumental responding in relation to specific compatible monetary rewards. Performance on the task was analysed between two groups of males based on Low (N = 38) and High (N = 41) self-report online sexual behaviour (OSB). Psychometric tests including sexual compul
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37

Petrie, Daniel J., Sy-Miin Chow, and Charles F. Geier. "Effective Connectivity during an Avoidance-Based Pavlovian-to-Instrumental Transfer Task." Brain Sciences 11, no. 11 (2021): 1472. http://dx.doi.org/10.3390/brainsci11111472.

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Pavlovian-to-instrumental transfer (PIT) refers to a phenomenon whereby a classically conditioned stimulus (CS) impacts the motivational salience of instrumental behavior. We examined behavioral response patterns and functional magnetic resonance imaging (fMRI) based effective connectivity during an avoidance-based PIT task. Eleven participants (8 females; Mage = 28.2, SD = 2.8, range = 25–32 years) completed the task. Effective connectivity between a priori brain regions engaged during the task was determined using hemodynamic response function group iterative multiple model estimation (HRF-G
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38

Sennwald, Vanessa, Eva R. Pool, Sylvain Delplanque, Francesco Bianchi-Demicheli, and David Sander. "Outcome-specific and general Pavlovian-to-instrumental transfers involving sexual rewards." Motivation Science 6, no. 1 (2020): 79–83. http://dx.doi.org/10.1037/mot0000129.

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39

Pielock, Steffi M., Stephanie Braun, and Wolfgang Hauber. "The effects of acute stress on Pavlovian-instrumental transfer in rats." Cognitive, Affective, & Behavioral Neuroscience 13, no. 1 (2012): 174–85. http://dx.doi.org/10.3758/s13415-012-0129-3.

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40

Seabrooke, Tina, Mike E. Le Pelley, Lee Hogarth, and Chris J. Mitchell. "Evidence of a goal-directed process in human Pavlovian-instrumental transfer." Journal of Experimental Psychology: Animal Learning and Cognition 43, no. 4 (2017): 377–87. http://dx.doi.org/10.1037/xan0000147.

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41

Campese, Vincent D., Jose M. Soroeta, Elena M. Vazey, Gary Aston-Jones, Joseph E. LeDoux, and Robert M. Sears. "Noradrenergic Regulation of Central Amygdala in Aversive Pavlovian-to-Instrumental Transfer." eneuro 4, no. 5 (2017): ENEURO.0224–17.2017. http://dx.doi.org/10.1523/eneuro.0224-17.2017.

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42

Nadler, Natasha, Mauricio R. Delgado, and Andrew R. Delamater. "Pavlovian to instrumental transfer of control in a human learning task." Emotion 11, no. 5 (2011): 1112–23. http://dx.doi.org/10.1037/a0022760.

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43

Lamb, R. J., Charles W. Schindler, and Jonathan W. Pinkston. "Conditioned stimuli’s role in relapse: preclinical research on Pavlovian-Instrumental-Transfer." Psychopharmacology 233, no. 10 (2016): 1933–44. http://dx.doi.org/10.1007/s00213-016-4216-y.

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44

Marshall, Andrew T., Briac Halbout, Christy N. Munson, Collin Hutson, and Sean B. Ostlund. "Flexible control of Pavlovian-instrumental transfer based on expected reward value." Journal of Experimental Psychology: Animal Learning and Cognition 49, no. 1 (2023): 14–30. http://dx.doi.org/10.1037/xan0000348.

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45

Hardy, Lorna, Chris Mitchell, Tina Seabrooke, and Lee Hogarth. "Drug cue reactivity involves hierarchical instrumental learning: evidence from a biconditional Pavlovian to instrumental transfer task." Psychopharmacology 234, no. 13 (2017): 1977–84. http://dx.doi.org/10.1007/s00213-017-4605-x.

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46

Lay, Belinda Po Pyn, and Shaun Yon-Seng Khoo. "Associative processes in addiction relapse models: A review of their Pavlovian and instrumental mechanisms, history, and terminology." Neuroanatomy and Behaviour 3 (February 23, 2021): e18. https://doi.org/10.35430/nab.2021.e18.

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Animal models of relapse to drug-seeking have borrowed heavily from associative learning approaches. In studies of relapse-like behaviour, animals learn to self-administer drugs then receive a period of extinction during which they learn to inhibit the operant response. Several triggers can produce a recovery of responding which form the basis of a variety of models. These include the passage of time (spontaneous recovery), drug availability (rapid reacquisition), extinction of an alternative response (resurgence), context change (renewal), drug priming, stress, and cues (reinstatement). In mo
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47

Meemken, Marie-Theres, and Annette Horstmann. "Appetitive Pavlovian-to-Instrumental Transfer in Participants with Normal-Weight and Obesity." Nutrients 11, no. 5 (2019): 1037. http://dx.doi.org/10.3390/nu11051037.

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Altered eating behavior due to modern, food-enriched environments has a share in the recent obesity upsurge, though the exact mechanisms remain unclear. This study aims to assess whether higher weight or weight gain are related to stronger effects of external cues on motivation-driven behavior. 51 people with and without obesity completed an appetitive Pavlovian-to-Instrumental Transfer (PIT) paradigm. During training, button presses as well as presentation of fractal images resulted in three palatable and one neutral taste outcome. In the subsequent test phase, outcome-specific and general be
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48

Alarcón, Daniel E., Charlotte Bonardi, and Andrew R. Delamater. "Associative mechanisms involved in specific Pavlovian-to-instrumental transfer in human learning tasks." Quarterly Journal of Experimental Psychology 71, no. 7 (2018): 1607–25. http://dx.doi.org/10.1080/17470218.2017.1342671.

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Four experiments compared the effect of forward and backward conditioning procedures on the ability of conditioned stimuli (CS) to elevate instrumental responding in a Pavlovian-to-instrumental transfer (PIT) task. Two responses were each trained with one distinct outcome (R1->O1, R2->O2), either concurrently (Experiment 1) or separately (Experiments 2, 3 and 4). Then, in Experiments 1 and 2, four CSs were either followed or preceded by one outcome (A->O1, B->O2, O1->C, O2->D). In Experiment 3, each CS was preceded and followed by an outcome: for one group of participants, bo
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49

Alarcón, Daniel, and Charlotte Bonardi. "The effect of conditioned inhibition on the specific Pavlovian-instrumental transfer effect." Journal of Experimental Psychology: Animal Learning and Cognition 42, no. 1 (2016): 82–94. http://dx.doi.org/10.1037/xan0000087.

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50

Homayoun, Houman, and Bita Moghaddam. "Differential representation of Pavlovian-instrumental transfer by prefrontal cortex subregions and striatum." European Journal of Neuroscience 29, no. 7 (2009): 1461–76. http://dx.doi.org/10.1111/j.1460-9568.2009.06679.x.

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