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Artículos de revistas sobre el tema "Trap-loss spectroscopy"

Autor: Grafiati

Publicado: 22 de febrero de 2025

Última modificación: 31 de julio de 2025

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1

WANG Li, 王丽, 张好 ZHANG Hao, and 张临杰 ZHANG Lin-jie. "Trap Loss Spectroscopy of Ultracold Cesium Rydberg Atoms." Acta Sinica Quantum Optica 24, no. 2 (2018): 178–83. http://dx.doi.org/10.3788/jqo20182402.0009.

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2

WANG Li, 王丽, 张好 ZHANG Hao, and 张临杰 ZHANG Lin-jie. "Trap Loss Spectroscopy of Ultracold Cesium Rydberg Atoms." Acta Sinica Quantum Optica 24, no. 2 (2018): 178–83. http://dx.doi.org/10.3788/jqo20182402.0501.

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3

Wang, Xin, Xiaokai Hou, Feifei Lu, et al. "Autler–Townes splitting in the trap-loss fluorescence spectroscopy due to single-step direct Rydberg excitation of cesium cold atomic ensemble." AIP Advances 13, no. 3 (2023): 035126. http://dx.doi.org/10.1063/5.0141479.

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We experimentally investigate trap-loss spectra of the cesium 6 S1/2( F = 4) → 71 P3/2 Rydberg transition by combining the cesium atomic magneto-optical trap with the narrow-linewidth, continuously tunable 318.6 nm ultraviolet laser. Specifically, the atoms in the magneto-optical trap are excited to the Rydberg state due to the ultraviolet laser single-step Rydberg excitation, which leads to the reduction of atomic fluorescence. Based on the trap-loss spectroscopy technology, the Autler–Townes (AT) splitting due to a strong cooling laser is observed, and the parameter dependence of the AT spli

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4

Wang, L. R., J. Ma, W. B. Ji, G. P. Wang, L. T. Xiao, and S. T. Jia. "Ultra-high resolution trap-loss spectroscopy of ultracold 133Cs atom long-range states in a magnetooptical trap." Laser Physics 17, no. 9 (2007): 1171–75. http://dx.doi.org/10.1134/s1054660x07090113.

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5

Snyder, Dalton T., Lucas J. Szalwinski, Robert L. Schrader, Valentina Pirro, Ryan Hilger, and R. Graham Cooks. "Precursor and Neutral Loss Scans in an RF Scanning Linear Quadrupole Ion Trap." Journal of The American Society for Mass Spectrometry 29, no. 7 (2018): 1345–54. http://dx.doi.org/10.1007/s13361-018-1920-3.

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6

Snyder, Dalton T., Lucas J. Szalwinski, Ryan Hilger, and R. Graham Cooks. "Implementation of Precursor and Neutral Loss Scans on a Miniature Ion Trap Mass Spectrometer and Performance Comparison to a Benchtop Linear Ion Trap." Journal of The American Society for Mass Spectrometry 29, no. 7 (2018): 1355–64. http://dx.doi.org/10.1007/s13361-018-1922-1.

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7

Szalwinski, Lucas J., Dalton T. Snyder, J. Mitchell Wells, and R. Graham Cooks. "Triple Resonance Methods to Improve Performance of Ion Trap Precursor and Neutral Loss Scans." Journal of the American Society for Mass Spectrometry 31, no. 5 (2020): 1123–31. http://dx.doi.org/10.1021/jasms.0c00048.

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8

Yang, Seung-Dong, Jun-Kyo Jung, Jae-Gab Lim, Seong-gye Park, Hi-Deok Lee, and Ga-Won Lee. "Investigation of Intra-Nitride Charge Migration Suppression in SONOS Flash Memory." Micromachines 10, no. 6 (2019): 356. http://dx.doi.org/10.3390/mi10060356.

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In order to suppress the intra-nitride charge spreading in 3D Silicon-Oxide-Nitride-Oxide-Silicon (SONOS) flash memory where the charge trapping layer silicon nitride is shared along the cell string, N2 plasma treated on the silicon nitride is proposed. Experimental results show that the charge loss decreased in the plasma treated device after baking at 300 °C for 2 h. To extract trap density according to the location in the trapping layer, capacitance-voltage analysis was used and N2 plasma treatment was shown to be effective to restrain the interface trap formation between blocking oxide and

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9

Du, Bin, Qian Liu, Yu Shi, and Yushun Zhao. "The Effect of Fe3O4 Nanoparticle Size on Electrical Properties of Nanofluid Impregnated Paper and Trapping Analysis." Molecules 25, no. 16 (2020): 3566. http://dx.doi.org/10.3390/molecules25163566.

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This paper systematically studies the effect of Fe3O4 nanoparticle size on the insulation performance of nanofluid impregnated paper. Three kinds of Fe3O4 nanoparticles with different sizes and their nanofluid impregnated papers were prepared. Environmental scanning electron microscopy (ESEM) and infrared spectroscopy were used to analyze the combination of Fe3O4 nanoparticles and nanofluid impregnated paper. The effect of nanoparticle size on breakdown voltage and several dielectric characteristics, e.g., permittivity, dielectric loss, of the nanofluid impregnated paper were comparatively inv

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10

Hou, Xiaokai, Yuewei Wang, Jun He, and Junmin Wang. "Asymmetry Analysis of the Autler–Townes Doublet in the Trap-Loss Fluorescence Spectroscopy of Cesium MOT with Single-Step Rydberg Excitation." Photonics 12, no. 5 (2025): 412. https://doi.org/10.3390/photonics12050412.

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The Autler–Townes (AT) doublet, a fundamental manifestation of quantum interference effects, serves as a critical tool for studying the dynamic behavior of Rydberg atoms. Here, we investigate the asymmetry of the Autler–Townes (AT) doublet in the trap-loss fluorescence spectroscopy (TLFS) of cesium (Cs) atoms confined in a magneto-optical trap (MOT) with single-step Rydberg excitation using a 319-nm ultraviolet (UV) laser. A V-type three-level system involving the ground state 6S1/2 (F = 4), excited state 6P3/2 (F′ = 5), and Rydberg state (nP3/2 (mJ = +3/2)) is theoretically modeled to analyze

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11

Qu, Xiangwei, and Xiaowei Sun. "Impedance spectroscopy for quantum dot light-emitting diodes." Journal of Semiconductors 44, no. 9 (2023): 091603. http://dx.doi.org/10.1088/1674-4926/44/9/091603.

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Abstract Impedance spectroscopy has been increasingly employed in quantum dot light-emitting diodes (QLEDs) to investigate the charge dynamics and device physics. In this review, we introduce the mathematical basics of impedance spectroscopy that applied to QLEDs. In particular, we focus on the Nyquist plot, Mott−Schottky analysis, capacitance-frequency and capacitance-voltage characteristics, and the dC/dV measurement of the QLEDs. These impedance measurements can provide critical information on electrical parameters such as equivalent circuit models, characteristic time constants, charge inj

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12

Ito, Shinobu, Tomohisa Mori, Hideko Kanazawa, and Toshiko Sawaguchi. "Estimation of the Postmortem Duration of Mouse Tissue by Electron Spin Resonance Spectroscopy." Journal of Toxicology 2011 (2011): 1–11. http://dx.doi.org/10.1155/2011/973172.

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Electron spin resonance (ESR) method is a simple method for detecting various free radicals simultaneously and directly. However, ESR spin trap method is unsuited to analyze weak ESR signals in organs because of water-induced dielectric loss (WIDL). To minimize WIDL occurring in biotissues and to improve detection sensitivity to free radicals in tissues, ESR cuvette was modified and used with 5,5-dimethtyl-1-pyrroline N-oxide (DMPO). The tissue samples were mouse brain, hart, lung, liver, kidney, pancreas, muscle, skin, and whole blood, where various ESR spin adduct signals including DMPO-asco

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13

Aoshima, Keito, Masahiro Horita, and Jun Suda. "Correlation between non-ionizing energy loss and production rate of electron trap at E_C − (0.12–0.20) eV formed in gallium nitride by various types of radiation." Applied Physics Letters 122, no. 1 (2023): 012106. http://dx.doi.org/10.1063/5.0128709.

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Production rate (PR = trap concentration/incident fluence) of traps formed by energetic particles is important for predicting device degradation caused by radiation when developing radiation-resistant devices. We demonstrate a clear correlation between non-ionizing energy loss (NIEL) and PR of an electron trap at about 0.12–0.20 eV below the conduction band edge [ EC − (0.12–0.20) eV] for various types of energetic particles in gallium nitride (GaN). NIEL values in GaN for electrons, protons, and [Formula: see text]-rays were calculated using a screened-relativistic treatment, and NIEL values

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14

Pan, Su, Kathryn Verhoeven, and Jeehiun K. Lee. "Investigation of the initial fragmentation of oligodeoxynucleotides in a quadrupole ion trap: Charge level-related base loss." Journal of the American Society for Mass Spectrometry 16, no. 11 (2005): 1853–65. http://dx.doi.org/10.1016/j.jasms.2005.07.009.

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15

Ma, Jie, Jizhou Wu, Yanting Zhao, Liantuan Xiao, and Suotang Jia. "Determination of the rotational constant of the Cs_2 0_g ^- (6s + 6p_3/2) state by trap loss spectroscopy." Optics Express 18, no. 16 (2010): 17089. http://dx.doi.org/10.1364/oe.18.017089.

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16

Comparat, D., C. Drag, A. Fioretti, O. Dulieu, and P. Pillet. "Photoassociative Spectroscopy and Formation of Cold Molecules in Cold Cesium Vapor: Trap–Loss Spectrum versus Ion Spectrum." Journal of Molecular Spectroscopy 195, no. 2 (1999): 229–35. http://dx.doi.org/10.1006/jmsp.1999.7764.

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17

Gonokami, Mio, Yoshimasa Yamamoto, Oraphin Chaikumpollert, Yoshito Ohtake, and Seiichi Kawahara. "ANTIOXIDANTS FOR EPDM SEALS EXPOSED TO CHLORINATED TAP WATER." Rubber Chemistry and Technology 87, no. 1 (2014): 1–9. http://dx.doi.org/10.5254/rct.13.87963.

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ABSTRACT A suitable antioxidant for a poly(ethylene-co-propylene-co-5-ethylidene-2-norbornene) (EPDM) seal in tap water applications was determined with respect to volatilization and decomposition of the antioxidants. Seals were prepared by mixing EPDM with 1 phr antioxidant and other ingredients followed by vulcanizing the mixture at 433 K for 20 min. The resulting EPDM seals were immersed into chlorinated water to investigate accelerated degradation. The change in antioxidant content was measured by gas chromatography/mass spectroscopy (GC/MS) and high-performance liquid chromatography (HPLC

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18

Bai, Jiandong, Shuo Liu, Jieying Wang, Jun He, and Junmin Wang. "Single-Photon Rydberg Excitation and Trap-Loss Spectroscopy of Cold Cesium Atoms in a Magneto-Optical Trap by Using of a 319-nm Ultraviolet Laser System." IEEE Journal of Selected Topics in Quantum Electronics 26, no. 3 (2020): 1–6. http://dx.doi.org/10.1109/jstqe.2019.2941483.

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19

Chang, Yuhan, Yi-min Hsiao, Chih-Chien Hu, et al. "Synovial Fluid Interleukin-16 Contributes to Osteoclast Activation and Bone Loss through the JNK/NFATc1 Signaling Cascade in Patients with Periprosthetic Joint Infection." International Journal of Molecular Sciences 21, no. 8 (2020): 2904. http://dx.doi.org/10.3390/ijms21082904.

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Because of lipopolysaccharide (LPS)-mediated effects on osteoclast differentiation and bone loss, periprosthetic joint infection (PJI) caused by Gram-negative bacteria increases the risk of aseptic loosening after reimplantation. Synovial fluid interleukin-16 (IL-16) expression was higher in patients with PJI than in patients without joint infection. Thus, we explored the effects of IL-16 on bone. We investigated whether IL-16 modulates osteoclast or osteoblast differentiation in vitro. An LPS-induced bone loss mice model was used to explore the possible advantages of IL-16 inhibition for the

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20

Marmet, L., and A. A. Madej. "Optical Ramsey spectroscopy and coherence measurements of the clock transition in a single trapped Sr ion." Canadian Journal of Physics 78, no. 5-6 (2000): 495–507. http://dx.doi.org/10.1139/p00-027.

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We report on the observation of coherent excitation and spectroscopy performed using Ramsey's method of separated excitation fields on a single trapped and laser cooled ion of strontium. Single pulse Rabi excitation studies of the ion have shown linewidths approaching the transform limited value. Studies of transition rate versus pulse duration have shown a quadratic initial increase in transition rate with a duration consistent with coherent excitation and a rapid loss of Rabi oscillations, consistent with the concept of a dephasing of the thermally populated trap oscillator states as the exc

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21

Kuhn, Fabian, Michael Oehme, Fernando Romero, Eliane Abou-Mansour, and Raffaele Tabacchi. "Differentiation of isomeric flavone/isoflavone aglycones by MS2 ion trap mass spectrometry and a double neutral loss of CO." Rapid Communications in Mass Spectrometry 17, no. 17 (2003): 1941–49. http://dx.doi.org/10.1002/rcm.1138.

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22

Li, Liang, Ming Yang, Saroj Kumar Shrestha, Hyoungsu Kim, William H. Gerwick, and Yunjo Soh. "Kalkitoxin Reduces Osteoclast Formation and Resorption and Protects against Inflammatory Bone Loss." International Journal of Molecular Sciences 22, no. 5 (2021): 2303. http://dx.doi.org/10.3390/ijms22052303.

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Osteoclasts, bone-specified multinucleated cells produced by monocyte/macrophage, are involved in numerous bone destructive diseases such as arthritis, osteoporosis, and inflammation-induced bone loss. The osteoclast differentiation mechanism suggests a possible strategy to treat bone diseases. In this regard, we recently examined the in vivo impact of kalkitoxin (KT), a marine product obtained from the marine cyanobacterium Moorena producens (previously Lyngbya majuscula), on the macrophage colony-stimulating factor (M-CSF) and on the receptor activator of nuclear factor κB ligand (RANKL)-sti

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23

Zeng, Yun, Yimin Xu, Chee-Leong Kee, Min-Yong Low, and Xiaowei Ge. "Analysis of 40 weight loss compounds adulterated in health supplements by liquid chromatography quadrupole linear ion trap mass spectrometry." Drug Testing and Analysis 9, no. 2 (2016): 334. http://dx.doi.org/10.1002/dta.2141.

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24

Tajima, Susumu, Low Foon Siang, Masao Fujishige, Satoshi Nakajima, and Osamu Sekiguchi. "Collision-induced dissociation spectra versus collision energy (collision-induced dissociation curve) using a quadrupole ion trap mass spectrometer. II.1 Loss of CO from ionizedo-,m- andp-anisoyl fluoride, CH3OC6H4COF+�." Journal of Mass Spectrometry 35, no. 9 (2000): 1144–46. http://dx.doi.org/10.1002/1096-9888(200009)35:9<1144::aid-jms43>3.0.co;2-q.

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25

Bi, Qi-rui, Jin-jun Hou, Min Yang, et al. "A Strategy Combining Higher Energy C-Trap Dissociation with Neutral Loss- and Product Ion-Based MSn Acquisition for Global Profiling and Structure Annotation of Fatty Acids Conjugates." Journal of The American Society for Mass Spectrometry 28, no. 3 (2016): 443–51. http://dx.doi.org/10.1007/s13361-016-1558-y.

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26

El-Tayeb, A., Fang Li, Akash Kumar, and Govindasamy Tamizhmani. "Electrical Impedance Spectroscopy: A Complementary Approach Differentiating PID Mechanisms in Photovoltaics." Electronics 14, no. 5 (2025): 1021. https://doi.org/10.3390/electronics14051021.

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Potential-induced degradation (PID) presents a critical reliability issue for solar photovoltaic (PV) modules, with three primary types identified in the literature, namely, PIDs (shunting type), PIDp (polarization type), and PIDc (corrosion type). Electrochemical/electrical impedance spectroscopy (EIS) is a highly effective but underutilized technique for differentiating between these PID mechanisms. When used alongside conventional I–V measurements (e.g., Isc, Voc, and FF), EIS offers direct insights into parameters such as Rs, Rp, and Cp, making it a valuable tool for PID type differentiati

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27

Yan, Zhixiang, Ge Lin, Yang Ye, Yitao Wang, and Ru Yan. "Triterpenoid saponins profiling by adducts-targeted neutral loss triggered enhanced resolution and product ion scanning using triple quadrupole linear ion trap mass spectrometry." Analytica Chimica Acta 819 (March 2014): 56–64. http://dx.doi.org/10.1016/j.aca.2014.02.019.

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28

Cheng, Jack, Bor-Tsang Wu, Hsin-Ping Liu, and Wei-Yong Lin. "Tyrosine Metabolism Pathway Is Downregulated in Dopaminergic Neurons with LRRK2 Overexpression in Drosophila." International Journal of Molecular Sciences 24, no. 21 (2023): 15587. http://dx.doi.org/10.3390/ijms242115587.

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LRRK2 mutations are the leading cause of familial Parkinson’s disease (PD) and are a significant risk factor for idiopathic PD cases. However, the molecular mechanisms underlying the degeneration of dopaminergic (DA) neurons in LRRK2 PD patients remain unclear. To determine the translatomic impact of LRRK2 expression in DA neurons, we employed gene set enrichment analysis (GSEA) to analyze a translating ribosome affinity purification (TRAP) RNA-seq dataset from a DA-neuron-specific-expressing Drosophila model. We found that the tyrosine metabolism pathway, including tyrosine hydroxylase (TH),

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29

Gonçalves, Vinícius de Paiva, Marta Liliana Musskopf, Angeliz Rivera-Concepcion, et al. "Systemic Dietary Hesperidin Modulation of Osteoclastogenesis, Bone Homeostasis and Periodontal Disease in Mice." International Journal of Molecular Sciences 23, no. 13 (2022): 7100. http://dx.doi.org/10.3390/ijms23137100.

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This study aimed to evaluate the effects of hesperidin (HE) on in vitro osteoclastogenesis and dietary supplementation on mouse periodontal disease and femoral bone phenotype. RAW 264.7 cells were stimulated with RANKL in the presence or absence of HE (1, 100 or 500 µM) for 5 days, and evaluated by TRAP, TUNEL and Western Blot (WB) analyses. In vivo, C57BL/6 mice were given HE via oral gavage (125, 250 and 500 mg/kg) for 4 weeks. A sterile silk ligature was placed between the first and second right maxillary molars for 10 days and microcomputed tomography (μCT), histopathological and immunohis

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30

Kelso, Celine, Juan Diego Rojas, Renata L. A. Furlan, Gabriel Padilla, and Jennifer L. Beck. "Characterisation of Anthracyclines from a Cosmomycin D-Producing Species of Streptomyces by Collisionally-Activated Dissociation and Ion Mobility Mass Spectrometry." European Journal of Mass Spectrometry 15, no. 2 (2009): 73–81. http://dx.doi.org/10.1255/ejms.948.

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Cultures of cosmomycin D-producing Streptomyces olindensis ICB20 that were propagated for many generations underwent mutations that resulted in production of a range of related anthracyclines by the bacteria. The anthracyclines that retained the two trisaccharide chains of the parent compound were separated by HPLC. Exact mass determination of these compounds revealed that they differed from cosmomycin D (CosD) in that they contained one to three fewer oxygen atoms (loss of hydroxyl groups). Some of the anthracyclines that were separated by HPLC had the same mass. The location from which the h

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31

Zhang, Rui, Keith J. Fisher, Derek R. Smith, et al. "An Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry Study of 1,6-Methano[60]Fullerene-61,61-Dicarboxylic Acid." European Journal of Mass Spectrometry 6, no. 2 (2000): 161–68. http://dx.doi.org/10.1255/ejms.336.

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1,6-Methano[60]fullerene-61,61-dicarboxylic acid was studied by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry. The deprotonated molecule, C60C(COOH)COO−, and the decarboxylated molecular anion C60CHCOO− were observed. Gas-phase ion–molecule reactions occurred when the ion accumulation time in an external rf/dc hexapole ion trap was extended. Cluster ions of the type [C60CHCOOH] n[C60CHCOO]− ( n = 1–2) were observed. Multiply-charged anions were observed for the dimer [C60CHCOOH][C60CHCOO]−. Collision-induced dissociation in the ion cyclotron resonance cell

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32

Grabitzki, Julia, Volker Sauerland, Rudolf Geyer, and Günter Lochnit. "Identification of Phosphorylcholine-Substituted Peptides by Their Characteristic Mass Spectrometric Fragmentation." European Journal of Mass Spectrometry 11, no. 3 (2005): 335–44. http://dx.doi.org/10.1255/ejms.728.

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Phosphorylcholine (PC)-substituted biomolecules are wide-spread, highly relevant antigens of parasites, since this small hapten has been found to be a potent immunomodulatory component which allows the establishment of long lasting infections of the host. Structural data, especially of protein bound PC-substituents, are still rare due to the observation that mass spectrometric analyses are mostly hampered by this zwitterionic substituent resulting in low sensitivities and unusual but characteristic fragmentation patterns. Here, we investigated the fragmentation behavior of synthetic PC-substit

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33

Hsu, Fong-Fu, and John Turk. "Studies on sulfatides by quadrupole ion-trap mass spectrometry with electrospray ionization: Structural characterization and the fragmentation processes that include an unusual internal galactose residue loss and the classical charge-remote fragmentation." Journal of the American Society for Mass Spectrometry 15, no. 4 (2004): 536–46. http://dx.doi.org/10.1016/j.jasms.2003.12.007.

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34

Scholz, Karoline, Wolfgang Dekant, Wolfgang Völkel, and Axel Pähler. "Rapid detection and identification of N-acetyl-L-cysteine thioethers using constant neutral loss and theoretical multiple reaction monitoring combined with enhanced product-ion scans on a linear ion trap mass spectrometer." Journal of the American Society for Mass Spectrometry 16, no. 12 (2005): 1976–84. http://dx.doi.org/10.1016/j.jasms.2005.08.003.

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35

Eisa, Nada H., Sakamuri V. Reddy, Ahmed M. Elmansi, et al. "Kynurenine Promotes RANKL-Induced Osteoclastogenesis In Vitro by Activating the Aryl Hydrocarbon Receptor Pathway." International Journal of Molecular Sciences 21, no. 21 (2020): 7931. http://dx.doi.org/10.3390/ijms21217931.

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There is increasing evidence of the involvement of the tryptophan metabolite kynurenine (KYN) in disrupting osteogenesis and contributing to aging-related bone loss. Here, we show that KYN has an effect on bone resorption by increasing osteoclastogenesis. We have previously reported that in vivo treatment with KYN significantly increased osteoclast number lining bone surfaces. Here, we report the direct effect of KYN on receptor activator of nuclear factor kappa-B ligand (RANKL)-induced osteoclastogenesis in Raw 264.7 macrophage cells, and we propose a potential mechanism for these KYN-mediate

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36

Chen, Zhihao, Eunjin Cho, Jinkyung Lee, Sunwoo Lee, and Tae-Hoon Lee. "Inhibitory Effects of N-[2-(4-acetyl-1-piperazinyl) phenyl]-2-(2-chlorophenoxy) acetamide on Osteoclast Differentiation In Vitro via the Downregulation of TRAF6." International Journal of Molecular Sciences 20, no. 20 (2019): 5196. http://dx.doi.org/10.3390/ijms20205196.

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Osteoclasts are poly-nuclear cells that resorb mineral components from old or damaged bone tissue. Primary mononuclear cells are activated by receptor activator of nuclear factor kappa-Β ligand (RANKL) and differentiate into large multinucleated cells. Dysregulation of osteoclast differentiation can lead to pathological bone loss and destruction. Many studies have focused on the development of new molecules to regulate RANKL-mediated signaling. In this study, N-[2-(4-acetyl-1-piperazinyl)phenyl]-2-(2-chlorophenoxy) acetamide (PPOA-N-Ac-2-Cl) led to a significant decrease in the formation of mu

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37

Lee, Chang Gun, Jeonghyun Kim, Seung Hee Yun, et al. "Anti-Osteoporotic Effect of Morroniside on Osteoblast and Osteoclast Differentiation In Vitro and Ovariectomized Mice In Vivo." International Journal of Molecular Sciences 22, no. 19 (2021): 10642. http://dx.doi.org/10.3390/ijms221910642.

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Bone remodeling is a continuous process of bone synthesis and destruction that is regulated by osteoblasts and osteoclasts. Here, we investigated the anti-osteoporotic effects of morroniside in mouse preosteoblast MC3T3-E1 cells and mouse primary cultured osteoblasts and osteoclasts in vitro and ovariectomy (OVX)-induced mouse osteoporosis in vivo. Morroniside treatment enhanced alkaline phosphatase activity and positively stained cells via upregulation of osteoblastogenesis-associated genes in MC3T3-E1 cell lines and primary cultured osteoblasts. However, morroniside inhibited tartrate-resist

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38

Kim, Su-Jin, Yun-Ho Hwang, Seul-Ki Mun та ін. "Protective Effects of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-d-glucoside on Ovariectomy Induced Osteoporosis Mouse Model". International Journal of Molecular Sciences 19, № 9 (2018): 2554. http://dx.doi.org/10.3390/ijms19092554.

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2,3,5,4′-Tetrahydroxystilbene-2-O-β-d-glucoside (TSG), an active polyphenolic component of Polygonum multiflorum, exhibits many pharmacological activities including antioxidant, anti-inflammation, and anti-aging effects. A previous study demonstrated that TSG protected MC3T3-E1 cells from hydrogen peroxide (H2O2) induced cell damage and the inhibition of osteoblastic differentiation. However, no studies have investigated the prevention of ovariectomy-induced bone loss in mice. Therefore, we investigated the effects of TSG on bone loss in ovariectomized mice (OVX). Treatment with TSG (1 and 3 μ

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39

Gierlikowska, Barbara, Albert Stachura, Wojciech Gierlikowski, and Urszula Demkow. "The Impact of Cytokines on Neutrophils’ Phagocytosis and NET Formation during Sepsis—A Review." International Journal of Molecular Sciences 23, no. 9 (2022): 5076. http://dx.doi.org/10.3390/ijms23095076.

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Sepsis is an overwhelming inflammatory response to infection, resulting in multiple-organ injury. Neutrophils are crucial immune cells involved in innate response to pathogens and their migration and effector functions, such as phagocytosis and neutrophil extracellular trap (NET) formation, are dependent on cytokine presence and their concentration. In the course of sepsis, recruitment and migration of neutrophils to infectious foci gradually becomes impaired, thus leading to loss of a crucial arm of the innate immune response to infection. Our review briefly describes the sepsis course, the i

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40

Auvray, Mihai, Lundberg, and Olsson. "Deactivation of Cu/SSZ-13 NH3-SCR Catalyst by Exposure to CO, H2, and C3H6." Catalysts 9, no. 11 (2019): 929. http://dx.doi.org/10.3390/catal9110929.

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Lean nitric oxide (NOx)-trap (LNT) and selective catalytic reduction (SCR) are efficient systems for the abatement of NOx. The combination of LNT and SCR catalysts improves overall NOx removal, but there is a risk that the SCR catalyst will be exposed to high temperatures and rich exhaust during the LNTs sulfur regeneration. Therefore, the effect of exposure to various rich conditions and temperatures on the subsequent SCR activity of a Cu-exchanged chabazite catalyst was studied. CO, H2, C3H6, and the combination of CO + H2 were used to simulate rich conditions. Aging was performed at 800 °C,

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41

Wu, Chia-Hsin, Ching-Huei Ou, I.-Chuan Yen, and Shih-Yu Lee. "4-Acetylantroquinonol B Inhibits Osteoclastogenesis by Inhibiting the Autophagy Pathway in a Simulated Microgravity Model." International Journal of Molecular Sciences 21, no. 18 (2020): 6971. http://dx.doi.org/10.3390/ijms21186971.

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Astronauts suffer from 1–2% bone loss per month during space missions. Targeting osteoclast differentiation has been regarded as a promising strategy to prevent osteoporosis in microgravity (μXg). 4-acetylantroquinonol B (4-AAQB), a ubiquinone from Antrodia cinnamomea, has shown anti-inflammatory and anti-hepatoma activities. However, the effect of 4-AAQB on μXg-induced osteoclastogenesis remains unclear. In this study, we aimed to explore the mechanistic impact of 4-AAQB on osteoclast formation under μXg conditions. The monocyte/macrophage-like cell line RAW264.7 was exposed to simulated μXg

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42

Liu, Cong-Jin, Xiao Yang, Shou-Hui Wang, et al. "Preventing Disused Bone Loss through Inhibition of Advanced Glycation End Products." International Journal of Molecular Sciences 24, no. 5 (2023): 4953. http://dx.doi.org/10.3390/ijms24054953.

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Bone loss occurs in astronauts during long-term space flight, but the mechanisms are still unclear. We previously showed that advanced glycation end products (AGEs) were involved in microgravity-induced osteoporosis. Here, we investigated the improvement effects of blocking AGEs formation on microgravity-induced bone loss by using the AGEs formation inhibitor, irbesartan. To achieve this objective, we used a tail-suspended (TS) rat model to simulate microgravity and treated the TS rats with 50 mg/kg/day irbesartan, as well as the fluorochrome biomarkers injected into rats to label dynamic bone

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43

Zhang, Zijiao, Juhan Song, Seung-Hee Kwon та ін. "Pirfenidone Inhibits Alveolar Bone Loss in Ligature-Induced Periodontitis by Suppressing the NF-κB Signaling Pathway in Mice". International Journal of Molecular Sciences 24, № 10 (2023): 8682. http://dx.doi.org/10.3390/ijms24108682.

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There has been increasing interest in adjunctive use of anti-inflammatory drugs to control periodontitis. This study was performed to examine the effects of pirfenidone (PFD) on alveolar bone loss in ligature-induced periodontitis in mice and identify the relevant mechanisms. Experimental periodontitis was established by ligating the unilateral maxillary second molar for 7 days in mice (n = 8 per group), and PFD was administered daily via intraperitoneal injection. The micro-computed tomography and histology analyses were performed to determine changes in the alveolar bone following the PFD ad

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44

Heinemann, Christiane, Josephine Adam, Benjamin Kruppke, Vera Hintze, Hans-Peter Wiesmann, and Thomas Hanke. "How to Get Them off?—Assessment of Innovative Techniques for Generation and Detachment of Mature Osteoclasts for Biomaterial Resorption Studies." International Journal of Molecular Sciences 22, no. 3 (2021): 1329. http://dx.doi.org/10.3390/ijms22031329.

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The fusion process of mononuclear monocytes into multinuclear osteoclasts in vitro is an essential process for the study of osteoclastic resorption of biomaterials. Thereby biomaterials offer many influencing factors such as sample shape, material composition, and surface topography, which can have a decisive influence on the fusion and thus the entire investigation. For the specific investigation of resorption, it can therefore be advantageous to skip the fusion on samples and use mature, predifferentiated osteoclasts directly. However, most conventional detachment methods (cell scraper, accu

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45

MAZUMDAR, Abhijit, Subrata ADAK, Ratna CHATTERJEE, and Ranajit K. BANERJEE. "Mechanism-based inactivation of lacrimal-gland peroxidase by phenylhydrazine: a suicidal substrate to probe the active site." Biochemical Journal 324, no. 3 (1997): 713–19. http://dx.doi.org/10.1042/bj3240713.

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Humans are exposed to various hydrazine derivatives for therapeutic control of several diseases, and mammalian peroxidases are implicated in the oxidative metabolism of many drugs. The results presented here indicate that lacrimal-gland peroxidase is irreversibly inactivated in a mechanism-based way by phenylhydrazine, which acts as a suicidal substrate in the presence of H2O2. The pseudo-first-order kinetic constants for inactivation at pH 5.5 are Ki=18 μM, kinact=0.25 min-1 and τ50=2.75 min, with a second-order rate constant of 0.75×104 M-1·min-1. Approx. 27 mol of phenylhydrazine and 54 mol

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46

Nasulewicz-Goldeman, Anna, Waldemar Goldeman, Anna Nikodem, et al. "Aromatic Bis[aminomethylidenebis(phosphonic)] Acids Prevent Ovariectomy-Induced Bone Loss and Suppress Osteoclastogenesis in Mice." International Journal of Molecular Sciences 22, no. 17 (2021): 9590. http://dx.doi.org/10.3390/ijms22179590.

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Osteoporosis is a skeletal disease associated with excessive bone turnover. Among the compounds with antiresorptive activity, nitrogen-containing bisphosphonates play the most important role in antiosteoporotic treatment. In previous studies, we obtained two aminomethylidenebisphosphonates—benzene-1,4-bis[aminomethylidene(bisphosphonic)] (WG12399C) acid and naphthalene-1,5-bis[aminomethylidene(bisphosphonic)] (WG12592A) acid—which showed a significant antiproliferative activity toward J774E macrophages, a model of osteoclast precursors. The aim of these studies was to evaluate the antiresorpti

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Kim, Eun-Nam, Ga-Ram Kim, Jae Sik Yu, Ki Hyun Kim та Gil-Saeng Jeong. "Inhibitory Effect of (2R)-4-(4-hydroxyphenyl)-2-butanol 2-O-β-d-apiofuranosyl-(1→6)-β-d-glucopyranoside on RANKL-Induced Osteoclast Differentiation and ROS Generation in Macrophages". International Journal of Molecular Sciences 22, № 1 (2020): 222. http://dx.doi.org/10.3390/ijms22010222.

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In bone homeostasis, bone loss due to excessive osteoclasts and inflammation or osteolysis in the bone formation process cause bone diseases such as osteoporosis. Suppressing the accompanying oxidative stress such as ROS in this process is an important treatment strategy for bone disease. Therefore, in this study, the effect of (2R)-4-(4-hydroxyphenyl)-2-butanol 2-O-β-d-apiofuranosyl-(1→6)-β-d-glucopyranoside (BAG), an arylbutanoid glycoside isolated from Betula platyphylla var. japonica was investigated in RANKL-induced RAW264.7 cells and LPS-stimulated MC3E3-T1 cells. BAG inhibited the activ

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48

Kouranti, Ilektra, Waed Abdel-Khalek, Stephani Mazurkiewicz, et al. "Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling." International Journal of Molecular Sciences 23, no. 9 (2022): 5151. http://dx.doi.org/10.3390/ijms23095151.

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Cullin 3 (CUL3) is the scaffold of Cullin3 Ring E3-ligases (CRL3s), which use various BTB-adaptor proteins to ubiquitinate numerous substrates targeting their proteasomal degradation. CUL3 mutations, responsible for a severe form of familial hyperkalemia and hypertension (FHHt), all result in a deletion of exon 9 (amino-acids 403-459) (CUL3-∆9). Surprisingly, while CUL3-∆9 is hyperneddylated, a post-translational modification that typically activates CRL complexes, it is unable to ubiquitinate its substrates. In order to understand the mechanisms behind this loss-of function, we performed comp

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49

Wu, Chao-Yi, Huang-Yu Yang, and Jenn-Haung Lai. "Anti-Citrullinated Protein Antibodies in Patients with Rheumatoid Arthritis: Biological Effects and Mechanisms of Immunopathogenesis." International Journal of Molecular Sciences 21, no. 11 (2020): 4015. http://dx.doi.org/10.3390/ijms21114015.

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Individuals with high anti-citrullinated protein antibody (ACPA) titers have an increased risk of developing rheumatoid arthritis (RA). Although our knowledge of the generation and production of ACPAs has continuously advanced during the past decade, our understanding on the pathogenic mechanisms of how ACPAs interact with immune cells to trigger articular inflammation is relatively limited. Citrullination disorders drive the generation and maintenance of ACPAs, with profound clinical significance in patients with RA. The loss of tolerance to citrullinated proteins, however, is essential for A

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50

Lee, Chang-Gun, Do-Wan Kim, Jeonghyun Kim, et al. "Effects of Loganin on Bone Formation and Resorption In Vitro and In Vivo." International Journal of Molecular Sciences 23, no. 22 (2022): 14128. http://dx.doi.org/10.3390/ijms232214128.

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Osteoporosis is a disease caused by impaired bone remodeling that is especially prevalent in elderly and postmenopausal women. Although numerous chemical agents have been developed to prevent osteoporosis, arguments remain regarding their side effects. Here, we demonstrated the effects of loganin, a single bioactive compound isolated from Cornus officinalis, on osteoblast and osteoclast differentiation in vitro and on ovariectomy (OVX)-induced osteoporosis in mice in vivo. Loganin treatment increased the differentiation of mouse preosteoblast cells into osteoblasts and suppressed osteoclast di

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