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Artículos de revistas sobre el tema "U e N-PLS/RBL"

Autor: Grafiati
Publicado: 4 de junio de 2021
Última modificación: 1 de febrero de 2022

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1

Zhu, Wei, Nan Jing Zhao, Rui Fang Yang, et al. "Simultaneous measurement of phenols by three-way fluorescence spectroscopy: A comparison of N-PLS/RBL, U-PLS/RBL and PARAFAC." Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 239 (October 2020): 118511. http://dx.doi.org/10.1016/j.saa.2020.118511.

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2

Navarro, Mercedes Villar, Miguel Angel Cabezón, and Patricia C. Damiani. "Simultaneous Determination of Pesticides in Fruits by Using Second-Order Fluorescence Data Resolved by Unfolded Partial Least-Squares Coupled to Residual Bilinearization." Journal of Chemistry 2018 (October 16, 2018): 1–17. http://dx.doi.org/10.1155/2018/3217465.

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In the present work, a chemometric-assisted spectrofluorimetric method has been developed for the simultaneous determination of natural fluorescent pesticides, carbaryl, carbendazim, and thiabendazole, in orange and banana. Only a simple extraction with methanol was required as sample pretreatment. Emission-excitation fluorescence matrices were obtained and resolved by using a second-order multivariate calibration method based on unfolded partial least-squares combined with residual bilinearization (U-PLS/RBL) for achieving “second-order advantage.” In this way, pesticides were determined in f
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3

Monago-Maraña, Olga, Teresa Galeano-Díaz, and Arsenio Muñoz de la Peña. "Chemometric Discrimination Between Smoked and Non-Smoked Paprika Samples. Quantification of PAHs in Smoked Paprika by Fluorescence-U-PLS/RBL." Food Analytical Methods 10, no. 4 (2016): 1128–37. http://dx.doi.org/10.1007/s12161-016-0676-2.

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4

Wang Yutian, 王玉田, 赵煦 Zhao Xu, 徐婧 Xu Jing, 苑媛媛 Yuan Yuanyuan, 张亚吉 Zhang Yaji, and 牛凯增 Niu Kaizeng. "Study on Three-Dimensional First-Order Derivative Fluorescence Spectra of Oil Mixture Based on U-PLS/RQL." Chinese Journal of Lasers 43, no. 5 (2016): 0515001. http://dx.doi.org/10.3788/cjl201643.0515001.

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5

Platzbecker, Uwe, Ulrich Germing, Katharina Götze, et al. "Luspatercept Increases Hemoglobin and Reduces Transfusion Burden in Patients with Low-Intermediate Risk Myelodysplastic Syndromes (MDS): Long-Term Results from Phase 2 PACE-MDS Study." Blood 128, no. 22 (2016): 3168. http://dx.doi.org/10.1182/blood.v128.22.3168.3168.

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Abstract Background: Management of anemia is a common therapeutic challenge in patients with MDS. Luspatercept (ACE-536), a fusion protein containing modified activin receptor type IIB, is being developed for treatment of anemia in lower-risk MDS. Luspatercept binds GDF11 and other TGF-β superfamily ligands to promote late-stage erythroid differentiation and increase hemoglobin (Hgb) levels (Suragani R, Nat Med, 2014 and Attie K, Am J Hematol, 2014). Aims: This is an ongoing, phase 2, multicenter, open-label, long-term extension study to evaluate the effects of luspatercept in patients (pts) w
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6

Mosca, A., A. Tagarelli, R. Paleari, P. Scarpelli, and C. Brancati. "Rapid determination of erythrocyte pyruvate kinase activity." Clinical Chemistry 39, no. 3 (1993): 512–16. http://dx.doi.org/10.1093/clinchem/39.3.512.

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Abstract We report a new potentiometric method for determining pyruvate kinase (PK). Enzymatic activity is measured by monitoring the change in pH produced in the reaction buffer under International Committee for Standardization in Haematology (ICSH) standardized assay conditions, and the lactate dehydrogenase reaction is automatically subtracted in each measuring cycle. The analysis, performed at 37 degrees C, requires a 10-microL sample (isolated erythrocytes or whole blood) and is completed in 2.5 min. The intra-assay CV is < 4% (PK between 3 and 35 U/g Hb); the interassay CV is 4.0%
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7

Wouters, Diana, Stephan Femke, Masja de Haas, et al. "C1-Inhibitor Rescues Red Blood Cells From Complement Mediated Destruction in Autoimmune Hemolytic Anemia." Blood 118, no. 21 (2011): 716. http://dx.doi.org/10.1182/blood.v118.21.716.716.

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Abstract Abstract 716 In autoimmune hemolytic anemia (AIHA) autoantibodies (auto-Ab's) to red blood cells (RBCs) may induce complement activation via the classical pathway of complement resulting in complement deposition on RBCs. RBCs coated with auto-Ab and/or complement (C3b) are removed by extravascular destruction in the spleen and liver. In a minority of cases complement activation proceeds until insertion of the membrane attack complex (MAC) resulting in intravascular hemolysis. The inflammatory response and the anoxia induced by hemolysis significantly contribute to the morbidity and fa
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8

Trout, Jonathan, Taylor Christiansen, M. Brooks Bulkley, et al. "Cognitive Impairments and Self-Reported Sleep in Early-Stage Parkinson’s Disease with Versus without Probable REM Sleep Behavior Disorder." Brain Sciences 10, no. 1 (2019): 9. http://dx.doi.org/10.3390/brainsci10010009.

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Parkinson’s disease (PD) is associated with cognitive and sleep impairments. The presence of rapid eye movement (REM) sleep behavior disorder (RBD) symptoms may represent a worse disease prognosis for PD individuals. We investigated cognitive functioning and self-reported sleep in early-stage PD individuals with (n = 19) or without (n = 31) probable RBD. Probable RBD was defined as >5 on the REM Sleep Behavior Disorder Screening Questionnaire. Inhibition, visuospatial cognitive abilities, working memory, sustained visual attention, verbal fluency, and episodic memory were assessed. Sleep im
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9

Soni, Hitesh, and Adebowale Adebiyi. "Pressor and renal regional hemodynamic effects of urotensin II in neonatal pigs." Journal of Endocrinology 217, no. 3 (2013): 317–26. http://dx.doi.org/10.1530/joe-12-0556.

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Renal expression of the peptide hormone urotensin II (UII) and its receptor (UTR) are dependent on kidney maturation and anatomical regions. However, renal regional hemodynamic effects of UII in neonates are unclear. Here, we investigated regional hemodynamic responses to acute intrarenal arterial administration of UII in newborn pigs. Western immunoblotting and immunofluorescence confirmed UTR expression and membrane localization in newborn pig renal afferent arterioles and afferent arteriolar smooth muscle cells respectively. Intrarenal arterial bolus injections of human UII (hUII; 1–100 ng/
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10

JURASEK, Miroslav, Tomislav POTOCKY, and Tereza VACINOVA. "F O R E I G N L A N G U A G E T E A C H I N G M E T H O D O L O G Y." Ezikov Svyat (Orbis Linguarum) 18, no. 1 (2020): 148–55. http://dx.doi.org/10.37708/ezs.swu.v18i1.18.

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The capability to use cultural cues in order to function effectively in culturally diverse situations has been measured by the fashionable concept of cultural intelligence (CQ) and its four dimensions (metacognitive CQ, cognitive CQ, motivational CQ and behavioral CQ) in a lot of previous studies and research. This capability is an important asset of the competitive portfolio for almost all companies in today's globalized world. Our study builds on a recent intensive research and brings anew the issue of CQ into the Czech environment. Specifically, the relationship between language skills and
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11

Marrero, Isabel. "The Role of Nonpolynomiality in Uniform Approximation by RBF Networks of Hankel Translates." Journal of Function Spaces 2019 (April 1, 2019): 1–10. http://dx.doi.org/10.1155/2019/1845491.

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Givenμ>-1/2andc∈I=]0,∞[, let the spaceCμ,c(respectively,Cμ) consist of all those continuous functionsuon]0,c](respectively,I) such that the limitlimz→0+⁡z-μ-1/2u(z)exists and is finite;Cμ,cis endowed with the uniform normuμ,∞,c=supz∈[0,c]⁡z-μ-1/2u(z) (u∈Cμ,c).Assumeϕ∈Cμdefines an absolutely regular Hankel-transformable distribution. Then, the linear span of dilates and Hankel translates ofϕis dense inCμ,cfor allc∈Iif, and only if,ϕ∉πμ, whereπμ=span{t2n+μ+1/2:n∈Z+}.
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12

Cadierno, Teresa. "Ellis, N. C., Römer, U., & O’Donnell, M. B. (2016). Usage-based approaches to language acquisition and processing: Cognitive and corpus investigations of Construction Grammar." Review of Cognitive Linguistics 15, no. 1 (2017): 289–96. http://dx.doi.org/10.1075/rcl.15.1.11cad.

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13

Guduric, Snezana, and Dragoljub Petrovic. "Prilog proucavanju fonetske prirode glasova u srpskom jeziku - lateralni glasovi." Juznoslovenski filolog, no. 63 (2007): 11–29. http://dx.doi.org/10.2298/jfi0763011g.

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(francuski) Ce texte porte sur la nature des sons lat?raux en langue serbe sur leurs points convergents et divergents, et en particulier sur leur distribution. En d?pit de leur mode de prononciation presque identique (passage lat?ral de l?air des deux cote de l?obstacle fait dans le r?sonateur buccal), les deux sons montrent des diff?rences importantes concernant tout autre caract?ristique. Le son dit palatal, par son image acoustique ressemble plus au son transitoire [j] ou au son nasal [n] qu?a sa paire lat?rale. C?est peut-?tre la raison pour laquelle on le substitue souvent par le [j] dans
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14

Della Porta, Matteo, Uwe Platzbecker, Valeria Santini, et al. "The Commands Trial: A Phase 3 Study of the Efficacy and Safety of Luspatercept Versus Epoetin Alfa for the Treatment of Anemia Due to IPSS-R Very Low-, Low-, or Intermediate-Risk MDS in Erythropoiesis Stimulating Agent-Naive Patients Who Require RBC Transfusions." Blood 136, Supplement 1 (2020): 1–2. http://dx.doi.org/10.1182/blood-2020-140284.

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Introduction: Anemia is the predominant cytopenia observed in patients with myelodysplastic syndromes (MDS), with many patients requiring regular red blood cell (RBC) transfusions. Erythropoiesis-stimulating agents (ESAs) remain a standard of care among patients with lower-risk MDS (LR-MDS), defined by International Prognostic Scoring System-Revised (IPSS-R) as Very Low-, Low-, or Intermediate-risk MDS, and endogenous serum erythropoietin (sEPO) levels ≤ 500 U/L. Recent studies of epoetin alfa and darbepoetin alfa have demonstrated efficacy among patients with LR-MDS, but the patient populatio
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15

Fenaux, Pierre, Ghulam J. Mufti, Rena Buckstein, et al. "Assessment of Longer-Term Efficacy and Safety in the Phase 3, Randomized, Double-Blind, Placebo-Controlled MEDALIST Trial of Luspatercept to Treat Anemia in Patients (Pts) with Revised International Prognostic Scoring System (IPSS-R) Very Low-, Low-, or Intermediate-Risk Myelodysplastic Syndromes (MDS) with Ring Sideroblasts (RS) Who Require Red Blood Cell (RBC) Transfusions." Blood 134, Supplement_1 (2019): 841. http://dx.doi.org/10.1182/blood-2019-123064.

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Introduction: Few treatment options are available to RBC transfusion-dependent pts with lower-risk MDS (LR-MDS) who are refractory/ineligible for erythropoiesis-stimulating agents (ESAs). Luspatercept is a first-in-class erythroid maturation agent that binds select TGF-β superfamily ligands to reduce aberrant Smad2/3 signaling and enhance late-stage erythropoiesis. In the phase 3, randomized, double-blind, placebo-controlled MEDALIST study (NCT02631070), luspatercept significantly reduced transfusion burden vs placebo. Longer-term efficacy analyses of the MEDALIST study (data cutoff Jan 7, 201
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16

Waltzman, Roger J., Patricia Braly, and Denise Williams. "Safety and Efficacy of Epoetin Alfa Initiated at 80,000 U Once Weekly in Anemic Cancer Patients Receiving Chemotherapy." Blood 104, no. 11 (2004): 4228. http://dx.doi.org/10.1182/blood.v104.11.4228.4228.

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Abstract Epoetin alfa (EPO) 40,000–60,000 U SC once weekly (QW) has been shown to increase hemoglobin (Hb) by ~2 g/dL after 8-12 wks in anemic patients (pts) with cancer receiving chemotherapy (CT). The proportion of pts achieving a hematologic response (HR; Hb ≥12 g/dL and/or Hb increase ≥2 g/dL from baseline [BL]) at this dosage was ~70%. It was hypothesized that higher initiation doses of EPO may result in earlier HR and improved HR rates. This nonrandomized, open-label, pilot study was designed to investigate the safety and efficacy of EPO 80,000 U SC QW for up to 12 wks in anemic (Hb ≤11
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17

Platzbecker, Uwe, Ulrich Germing, Aristoteles Giagounidis, et al. "Biomarkers of Ineffective Erythropoiesis Predict Response to Luspatercept in Patients with Low or Intermediate-1 Risk Myelodysplastic Syndromes (MDS): Final Results from the Phase 2 PACE-MDS Study." Blood 126, no. 23 (2015): 2862. http://dx.doi.org/10.1182/blood.v126.23.2862.2862.

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Abstract Background: Luspatercept is a fusion protein (modified activin receptor IIB-IgG Fc) being investigated for the treatment of anemias with ineffective erythropoiesis. MDS patients have increased Smad2/3 signaling in the bone marrow, leading to ineffective erythropoiesis. Luspatercept inhibits Smad2/3 signaling and promotes late-stage erythroid differentiation, thereby correcting ineffective erythropoiesis. Aims: This completed, 3-month, phase 2, multicenter, open-label study evaluated the effects of luspatercept on anemia in patients with low/int-1 risk MDS (IPSS classification). Study
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18

Sibon, David, Giovanna Cannas, Fiorenza Barraco, et al. "Lenalidomide (LEN) In Lower-Risk Myelodysplastic Syndromes (MDS) with Karyotypes Other Than Deletion 5q and Refractory to Erythropoiesis-Stimulating Agents (ESAs)." Blood 116, no. 21 (2010): 4002. http://dx.doi.org/10.1182/blood.v116.21.4002.4002.

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Abstract Abstract 4002 Background. In lower-risk MDS, anemia is the main therapeutic challenge. ESAs can frequently correct anemia, but not all pts respond and median response duration to ESAs is only about 2 years. LEN yields RBC transfusion-independence (TI) in 65% of lower risk MDS with del(5q)] and about 25% of lower risk MDS without del 5q (Raza A, et al, Blood, 2008, 111, 1). However, in the last study, pretreatment with ESAs was not always documented, and the efficacy of LEN on anemia of non-del(5q) MDS refractory to ESAs remains unknown. Patients and Methods: 31 consecutive lower-risk
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19

Shankar, Kartik, Ying Zhong, Ping Kang, Keshari Thakali, Brian Piccolo, and Aline Andres. "Maternal Obesity and Diet Quality Modulate the Villous Placental Metabolome." Current Developments in Nutrition 4, Supplement_2 (2020): 1076. http://dx.doi.org/10.1093/cdn/nzaa054_148.

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Abstract Objectives Maternal diet and body composition are important determinants of offspring obesity risk, which may be mediated via changes in placental function. Here we examined the influence of maternal obesity and diet quality on the placental metabolome using untargeted metabolomics. Methods Placenta were collected from a longitudinal observational study in which maternal anthropometrics, body composition, dietary intake (3 d food records) and other variables were collected every trimester. Untargeted metabolomics of villous placental tissues from normal weight (NW, n = 72), overweight
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20

Almeida, Antonio Medina, Camille L. Bedrosian, Alexander Cole, et al. "Clinical Benefit of Eculizumab in Patients with No Transfusion History in the International Paroxysmal Nocturnal Hemoglobinuria Registry." Blood 126, no. 23 (2015): 3340. http://dx.doi.org/10.1182/blood.v126.23.3340.3340.

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Abstract Introduction: Studies in patients with paroxysmal nocturnal hemoglobinuria (PNH) have shown that eculizumab reduces intravascular hemolysis, improves disease symptoms, and increases life expectancy. The objective of this analysis was to characterize, in a real-world setting, the benefit of eculizumab therapy in patients with PNH with no history of red blood cell (RBC) transfusion, with a special focus on high disease activity (HDA). Methods: The International PNH Registry is a prospective, observational study of patients with a PNH clone of 0.01-100%. Three patient populations were st
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21

Canalli, Andreia A., Carla F. Franco-Penteado, Fabiola Traina, et al. "Altered Red Cell and Platelet Adhesion in the Hemolytic Diseases: Hereditary Spherocytosis, Paroxysmal Nocturnal Hemoglobinuria and Sickle Cell Anemia." Blood 108, no. 11 (2006): 1238. http://dx.doi.org/10.1182/blood.v108.11.1238.1238.

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Abstract Increasing evidence exists to suggest that intravascular hemolysis may have important pathophysiological consequences resulting from reduced vascular nitric oxide (NO) bioavailability due to hemoglobin-mediated NO scavenging; such consequences may include endothelial dysfunction and vasculopathy. Hemolytic diseases such as hereditary spherocytosis (HS), paroxysmal nocturnal hemoglobinuria (PNH) and sickle cell anemia (SCA), despite having diverse etiologies, share a number of complications that include pulmonary and systolic arterial hypertension, cutaneous leg ulcerations and, in PNH
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22

Gerds, Aaron T., Alessandro M. Vannucchi, Francesco Passamonti, et al. "Duration of Response to Luspatercept in Patients (Pts) Requiring Red Blood Cell (RBC) Transfusions with Myelofibrosis (MF) - Updated Data from the Phase 2 ACE-536-MF-001 Study." Blood 136, Supplement 1 (2020): 47–48. http://dx.doi.org/10.1182/blood-2020-137265.

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Introduction: MF is a clonal stem cell disorder characterized by progressive bone marrow failure, extramedullary hematopoiesis, and debilitating constitutional symptoms. Approximately 60% of pts develop anemia within a year of diagnosis; pts who are transfusion dependent have worse survival and quality-of-life outcomes (Tefferi A, et al. Mayo Clin Proc 2012;87:25-33). Treatment for MF-associated anemia remains critically unaddressed, with no approved therapies available. Luspatercept is a first-in-class erythroid maturation agent that has been shown to increase hemoglobin and reduce transfusio
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23

Leitch, Heather A., Hatoon Ezzat, Meaghan D. Rollins, et al. "Transfusion Dependence in Patients with Primary Myelofibrosis Has a Negative Impact on Survival Independent of Decreased Myelopoiesis." Blood 110, no. 11 (2007): 4653. http://dx.doi.org/10.1182/blood.v110.11.4653.4653.

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Abstract Primary myelofibrosis (PMF) is a myeloproliferative disorder characterized by progressive bone marrow failure, extramedullary hematopoiesis and risk of progression to blast phase (BP). Many PMF patients (pts) require red blood cell (RBC) transfusions, risking iron overload (IOL)-related organ dysfunction. Pts with myelodysplastic syndrome and RBC transfusion dependence (TD) have worse overall survival (OS), which may be improved by iron chelation therapy (ICT). To assess the effect of TD and ICT on survival in PMF, we reviewed 30 pts seen from 1985 to 2007 with a marrow biopsy confirm
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24

Günaydın, Kemal, and Ayten Günaydın. "Peak Ground Acceleration Prediction by Artificial Neural Networks for Northwestern Turkey." Mathematical Problems in Engineering 2008 (2008): 1–20. http://dx.doi.org/10.1155/2008/919420.

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Three different artificial neural network (ANN) methods, namely, feed-forward back-propagation (FFBP), radial basis function (RBF), and generalized regression neural networks (GRNNs) were applied to predict peak ground acceleration (PGA). Ninety five three-component records from 15 ground motions that occurred in Northwestern Turkey between 1999 and 2001 were used during the applications. The earthquake moment magnitude, hypocentral distance, focal depth, and site conditions were used as inputs to estimate PGA for vertical (U-D), east-west (E-W), and north-south (N-S) directions. The direction
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25

Çiçek, Güner. "The Effects of Different Exercise Types on Hematological Parameters in Sedentary Women." Journal of Education and Training Studies 6, no. 8 (2018): 96. http://dx.doi.org/10.11114/jets.v6i8.3374.

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The purpose of this study is to investigate the effect of aerobic and strength exercises on hematological parameters in sedentary women. To achieve the purpose of this study, a total of 23 volunteers including aerobic exercise group (AE, n: 10), strength exercise group (SE, n:13) were selected as participants. Two different exercises were applied for 4 days a week, throughout 16 weeks, within 60 minutes for each exercise with the intensity of heart rate (HR) 60-70 percent. The HR was measured using a heart rate monitor for each subject.The women's white blood cell (WBC), thrombocyte (PLT), red
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26

Mattè, Alessandro, Wilson Anand, Enrica Federti, et al. "The Pyruvate Kinase Activator Mitapivat Ameliorates Anemia and Prevents Iron Overload in a Mouse Model of Hereditary Spherocytosis." Blood 136, Supplement 1 (2020): 29. http://dx.doi.org/10.1182/blood-2020-142232.

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Hereditary spherocytosis (HS) is the most common cause of inherited red cell membranopathy, due to mutations in genes encoding for membrane or cytoskeletal proteins, including band 3, ankyrin, spectrin, band 4.1 or band 4.2. Membrane instability results in membrane surface area loss and generation of spherocytic red cells with elevated MCHC, decreased cellular deformability and reduced red cell survival, due to splenic sequestration. Clinical management of the hemolytic anemia due to HS depends on the age of the patient and the severity of anemia. Splenectomy is indicated in children with symp
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27

Korac, Vojislav. "Smisao gradjenja po uzoru - primeri u srpskoj arhitekturi XIV veka." Zbornik radova Vizantoloskog instituta, no. 41 (2004): 205–12. http://dx.doi.org/10.2298/zrvi0441205k.

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(francuski) Ce travail a pour objet les monuments du XIVe si?cle dont l'?rection s'inscrit dans un courant ind?pendant de la tendance alors dominante dans l'architecture serbe. Par construction sur un mod?le donn? on entend le ph?nom?ne enregistr? dans l'architecture serbe du XIIIe si?cle et connu sous le nom d'?cole de Rascie. Se tournant vers l'architecture byzantine la construction sacr?e a alors produit en Serbie une s?rie d'ouvrages se distinguant par leurs conceptions reprenant celles de l'architecture de la renaissance des Pal?ologue. Cette innovation ?tait une cons?quence d'un changeme
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Chierichini, Anna, Barbara Anaclerico, Paola Anticoli Borza, et al. "Darbepoietin in Autologous Peripheral Blood Stem Cell Transplantation (ASCT): A Pilot Study." Blood 110, no. 11 (2007): 5101. http://dx.doi.org/10.1182/blood.v110.11.5101.5101.

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Abstract In patients undergoing ASCT, RBC transfusions are depending on donor availability and correlated with early and late side effects such as immune reactions and infections. Three weeks long acting Darbepoietin is currently available, but its role in ASCT in terms of efficacy, safety and cost has not yet been established. Aim: This pilot study was activated in ASCT patients to test the impact of Darbepoietin on the haemoglobin level; RBC transfusion requirement; the total cost of Darbepoietin therapy during the first 30 days after ASCT. Material and methods. From September 2006 to June 2
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29

Djokovic, Zorica. "Stanovnistvo istocne Makedonije u prvoj polovini XIV veka." Zbornik radova Vizantoloskog instituta, no. 40 (2003): 97–244. http://dx.doi.org/10.2298/zrvi0340097d.

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(francuski) Le but du pr?sent ouvrage est de pr?senter la structure ethnique de la Mac?doine de l'Est dans la p?riode entre 1300 et 1341, et cela en se basant sur les donn?es anthroponymiques. Cette limitation dans le temps et l'espace a ?t? impos?e par les sources elles-m?me, qui sont les praktika (une sorte de registre des cadastres) des monast?res d'Athos, car ils sont les seuls ? avoir ?t? conserv?s. Les monast?res en question avaient eu des propri?t?s dans cette r?gion-l? et c'est uniquement pour cette p?riode qu'ils permettent de suivre continuellement la population dans certains village
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30

PUTRA, ANAK AGUNG GEDE, PANDE GEDE GUNAMANTA, and KETUT TURAINI INDRA WINTEN. "PEMBERIAN NUTRISI GOODPLANT PADA BERBAGAI UMUR BIBIT SECARA HIDROPONIK SISTEM NFT TERHADAP HASIL TANAMAN SELADA MERAH." GANEC SWARA 15, no. 1 (2021): 842. http://dx.doi.org/10.35327/gara.v15i1.182.

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Research on the provision of Good plant nutrition at various ages of seeds using hydroponics NFT systems on the yield of red lettuce plants. This research is conducted in the experimental garden of the Faculty of Science and Technology, Tabanan University from October 2019 to December 2019. This research used a randomized block design (RBD). The experimental treatments consisted of 2 factors, namely the dose of Good plant nutrition and the age of the seeds. The first factor is the provision of a dose of Good plant (N) nutrition consisting of N1 = 800 ppm; N2 = 1000 ppm; N3 = 1200 ppm, and the
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31

Chan, Lap Shu Alan, Roman Shapiro, Rena Buckstein, et al. "Initial Transfusion Rate Predicts Survival in MDS." Blood 118, no. 21 (2011): 2791. http://dx.doi.org/10.1182/blood.v118.21.2791.2791.

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Abstract Abstract 2791 Introduction: Most MDS patients require chronic red blood cell (RBC) transfusion. Despite the immediate benefit of transfusion, transfusion dependence in MDS is a negative prognostic factor for overall survival. It has been suggested that transfusional iron overload, which is linked to toxicity through oxidative stress, contributes to poorer disease outcome and even to the progression of MDS to acute leukaemia. Alternatively, transfusion requirements may merely reflect disease severity in MDS and hence inferior disease outcome. To date, the exact relationship between tra
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32

Shen, Jessica, Naritsara Wongtong, Denis Noubouossie, et al. "Lack of Difference in Hepcidin Levels in Sickle Cell Anemia and Sickle Cell Beta Thalassemia." Blood 126, no. 23 (2015): 4591. http://dx.doi.org/10.1182/blood.v126.23.4591.4591.

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Abstract Introduction: Sickle cell disease (SCD) may be associated with iron overload following repeated RBC transfusions. In beta thalassemia major, a disease characterized by hemolysis and ineffective erythropoiesis, iron overload occurs due to both repeated RBC transfusions and hyperabsorption of iron. Hyperabsorption of iron occurs due to ineffective erythropoiesis and subsequent downregulation of hepcidin, the main regulator of systemic iron homeostasis. With the presence of a thalassemia gene, HbSβ-thalassemia patients may have an increased tendency to hyperabsorb iron compared to HbSS p
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33

Gerds, Aaron T., Alessandro M. Vannucchi, Francesco Passamonti, et al. "A Phase 2 Study of Luspatercept in Patients with Myelofibrosis-Associated Anemia." Blood 134, Supplement_1 (2019): 557. http://dx.doi.org/10.1182/blood-2019-122546.

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Introduction: Approximately two-thirds of patients with primary or post-essential thrombocythemia/polycythemia vera myelofibrosis (MF) have anemia, many of whom require red blood cell (RBC) transfusions. In this heavily transfused population there are severely limited treatment options; effective treatment for anemia in MF is a critically unmet medical need. Luspatercept is a first-in-class erythroid maturation agent which binds to select TGF-β superfamily ligands to reduce aberrant Smad2/3 signaling and enhance late-stage erythropoiesis. Here we report the interim results of the ongoing open-
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34

Omar, Nor Asiah, Najeeb Ullah Shah, Norhafizah Abu Hasan, and Mohd Helmi Ali. "THE INFLUENCE OF SELF-EFFICACY, MOTIVATION, AND INDEPENDENCE ON STUDENTS’ ENTREPRENEURIAL INTENTIONS." Journal of Nusantara Studies (JONUS) 4, no. 2 (2019): 1–28. http://dx.doi.org/10.24200/jonus.vol4iss2pp1-28.

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Entrepreneurship education has been implemented in higher institutions in order to give exposure and develop students’ skills and interest in business. Although entrepreneurship course is taught in many universities, researchers are still arguing whether entrepreneurship education is related to the intention to start a business. This study investigated the impact of self-efficacy, independence, and motivation on entrepreneurial intentions among university students. A total of 496 questionnaires were completed by students of Universiti Kebangsaan Malaysia (UKM) who attended Fundamental of Entre
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35

Peerschke, Ellinor I. B., Richard T. Silver, Babette Weksler, Naphtali Savion, and David Varon. "Effect of ADP and ATP Receptor Antagonism on Erythrocytosis-Induced Platelet Aggregate Formation under Dynamic Flow Conditions." Blood 104, no. 11 (2004): 3903. http://dx.doi.org/10.1182/blood.v104.11.3903.3903.

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Abstract Red blood cells (RBC) contribute significantly to hemostasis and thrombosis under oscillatory flow conditions, and erythrocytosis has been associated with increased thrombotic risk. To capture dynamic effects of RBC on platelets, we used a recently described Cone and Plate (let) Analyzer (CPA), to evaluate the effect of hematocrit (Hct) on platelet function in whole blood under arterial flow conditions (1800 sec-1, 2 min, 25°C). Anticoagulated blood, reconstituted to varying hematocrits with autologous RBC, demonstrated a significant increase (30–50%, n= 12, p < 0.05) in adherent p
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36

Messino, Michael, Eric McGary, and Denise Williams. "Epoetin Alfa 60,000 U SC QW Induction Followed by 60,000 U SC Q2W: Final Study Results of a Novel Treatment Strategy for Chemotherapy-Related Anemia." Blood 104, no. 11 (2004): 4226. http://dx.doi.org/10.1182/blood.v104.11.4226.4226.

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Abstract Epoetin alfa (EPO) 40,000–60,000 U administered SC QW has been shown to significantly reduce transfusion utilization, increase Hb, and improve quality of life in anemic patients (pts) with cancer receiving chemotherapy (CT). The use of higher initiation doses of epoetin alfa followed by less frequent maintenance dosing was evaluated to provide convenience and dosing flexibility for both pts and clinicians. This open-label, multicenter, pilot study investigated the efficacy of EPO at a starting dose of 60,000 U SC QW for 4 weeks (wks) followed by 60,000 U SC administered every 2 weeks
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37

Nursanti, Ida. "TANGGAP BIBIT KAKAO TERHADAP MEDIA TANAM GAMBUT DAN ULTISOL SERTA ZEOLIT." Jurnal Media Pertanian 2, no. 2 (2017): 47. http://dx.doi.org/10.33087/jagro.v2i2.35.

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Peat soils and mineral soils have poor chemical and biological properties. The addition of mineral soil and zeolite in peat plant media will improve the soil properties. The aim of this research is to know the effect of ultisol and zeolite soil on peat media and to determine the ratio of ultisol and peat soil media and zeolite for the growth of cocoa seedlings. Implementation of research in Jambi City. The study used Completely Randomized Design (RAL) with 2 factors. Giving ultisol soil (U) with 4 levels : U0 = without ultisol soil, U1 = ultisol soil 15% by weight of planting medium, U2 = ulti
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38

Shasha, Daniel, and David H. Henry. "Hematopoietic Response to Extended Dosing of Epoetin alfa 60,000 U Every 2 Weeks in Anemic Cancer Patients Not Receiving Therapy: Final Results." Blood 106, no. 11 (2005): 3764. http://dx.doi.org/10.1182/blood.v106.11.3764.3764.

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Abstract Epoetin alfa administered weekly raises hemoglobin (Hb) in anemic cancer patients not receiving therapy. For optimal management of this group of patients more information is needed about extended dosing intervals. The objective of this open-label, single arm, multicenter study was to evaluate the hematopoietic response (HR) when anemic cancer patients not receiving chemotherapy (CT) or radiotherapy (RT) were treated with 60,000 U of epoetin alfa every two weeks (Q2W). Patients with non-myeloid malignancy, no CT within 8 weeks or RT within 4 weeks prior to study entry, and baseline Hb
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39

Ley, Benedikt, Mohammad Shafiul Alam, Mohammad Golam Kibria, et al. "Glucose-6-phosphate dehydrogenase activity in individuals with and without malaria: Analysis of clinical trial, cross-sectional and case–control data from Bangladesh." PLOS Medicine 18, no. 4 (2021): e1003576. http://dx.doi.org/10.1371/journal.pmed.1003576.

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Background Glucose-6-phosphate dehydrogenase (G6PD) activity is dependent upon G6PD genotype and age of the red blood cell (RBC) population, with younger RBCs having higher activity. Peripheral parasitemia with Plasmodium spp. induces hemolysis, replacing older RBCs with younger cells with higher G6PD activity. This study aimed to assess whether G6PD activity varies between individuals with and without malaria or a history of malaria. Methods and findings Individuals living in the Chittagong Hill Tracts of Bangladesh were enrolled into 3 complementary studies: (i) a prospective, single-arm cli
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40

Brodsky, R. A., P. Hillmen, J. Schubert, et al. "Safety and efficacy of eculizumab in paroxysmal nocturnal hemoglobinuria evolving from patients with myelodysplastic syndrome and aplastic anemia." Journal of Clinical Oncology 25, no. 18_suppl (2007): 7033. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.7033.

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7033 Background: Myelodysplastic syndrome (MDS) and aplastic anemia (AA) have been reported to be associated with the development of the acquired clonal hemolytic and bone marrow failure disorder, paroxysmal nocturnal hemoglobinuria (PNH). Two recent phase 3 clinical studies have demonstrated significant benefit of the complement inhibitor eculizumab (Soliris) in a heterogeneous population of patients with PNH (n=140). Methods: To investigate whether eculizumab was safe and effective in PNH patients with a history of MDS or AA (n=37), efficacy parameters were examined in the MDS/AA patient sub
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41

Stevens, W. T., A. M. Reese, R. Wesley, et al. "Prospective Evaluation of Immune Hemolysis in Minor-ABO Incompatible Reduced-Intensity Peripheral Blood (PB) Hematopoietic Cell Transplantation (HCT)." Blood 106, no. 11 (2005): 960. http://dx.doi.org/10.1182/blood.v106.11.960.960.

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Abstract Background: Life-threatening immune hemolysis may complicate minor-ABO incompatible HCT. Strategies for laboratory monitoring and proposed risk factors for hemolysis such as reduced intensity conditioning, non HLA-matched-sibling donors, CsA alone as GVHD prophylaxis, and PB rather than marrow have not previously been evaluated prospectively. Study Design: Following fatal massive hemolysis in an index patient, we prospectively evaluated 40 consecutive, lymphocyte-replete, ABO-minor incompatible PB HCT following fludarabine/cyclophosamide(CY)-based reduced-intensity conditioning, with
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42

Leitch, Heather A., Dominic H. C. Wong, Chantal S. Leger, et al. "Improved Leukemia-Free and Overall Survival in Patients with Myelodysplastic Syndrome Receiving Iron Chelation Therapy: A Subgroup Analysis." Blood 110, no. 11 (2007): 1469. http://dx.doi.org/10.1182/blood.v110.11.1469.1469.

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Abstract Myelodysplastic syndrome (MDS) is characterized by ineffective hematopoiesis and risk of progression to acute myeloid leukemia (AML). Many MDS patients (pts) require red blood cell (RBC) transfusions, risking iron overload (IOL)-related organ dysfunction. We previously showed in a multivariate analysis of 178 pts, improved survival in 18 pts with low and int-1 IPSS risk MDS and IOL receiving iron chelation therapy (ICT), and now examine the effect of ICT on AML-free survival (LFS). The effect of ICT on cytopenias and RBC transfusion requirements (TR); was also examined. To control for
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43

Taherian, Mehran, Zhonghua Liu, and Melissa Petras. "Diagnosis of Rare Antibody Anti-Ata in Pregnancy: A Case Report." American Journal of Clinical Pathology 152, Supplement_1 (2019): S152—S153. http://dx.doi.org/10.1093/ajcp/aqz131.004.

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Abstract Background Anti-Augustine antigen (Ata) is a high-prevalence RBC antigen, and anti-Ata is an extremely rare RBC alloantibody. Anti-Ata is usually produced by an Ata (–) individual after alloimmunization by transfusion or during a pregnancy and is associated with immediate or delayed hemolytic transfusion reactions and hemolytic disease of the fetus and newborn. We report the detection of a unique antibody to an antigen of high incidence, the anti-Ata. Case Presentation The patient was a 26-year-old African American pregnant female G7P2042 with a medical history of beta-thalassemia tra
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44

Park, Sophie, C. Kelaidi, Rosa Sapena, et al. "Early Treatment of Anemia of Lower Risk MDS by Erythropoiesis-Stimulating Agents (ESAs): A Report On 112 Cases." Blood 114, no. 22 (2009): 1765. http://dx.doi.org/10.1182/blood.v114.22.1765.1765.

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Abstract Abstract 1765 Poster Board I-791 Background ESAs are frequently effective in anemia of lower risk MDS, and at least 2 groups have shown that ESAs did not increase the risk of AML progression while possibly improving overall survival (OS) in those patients (pts) (Blood 2008:111: 574-582, JCO 2008, 26: 3607-13). Although responses to ESAs are generally transient and most pts ultimately require RBC transfusions, ESAs are increasingly used before RBC transfusion requirement, and we evaluated this attitude in our GFM experience. Patients : In a cohort of 403 MDS patients (pts) treated with
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45

Madany, Emaan, Najwa El Kadi, Sumaarg Pandya, Jeanne E. Hendrickson, and David R. Gibb. "Increased Expression of Type 1 Interferon Stimulated Genes in Sickle Cell Disease and a Potential Association with RBC Alloimmunization." Blood 134, Supplement_1 (2019): 716. http://dx.doi.org/10.1182/blood-2019-124899.

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Background RBC transfusion can lead to the production of alloantibodies against RBC antigens and is a clinically significant issue in transfusion medicine. Patients with sickle cell disease have an increased risk for alloimmunization; 30-50% of SS patients have alloantibodies compared to 3-10% of other hospitalized patients. These alloantibodies can cause dangerous hemolytic transfusion reactions and limit the availability of compatible antigen-negative RBC products. This is of particular importance in SS patients, who commonly make alloantibodies against multiple RBC antigens and need regular
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46

Youssef, Lama A., Dilman Haj Hussien, and Siham Sulaiman. "The Effectiveness of a Fixed Low Dose of Erythropoietin (EPO) in Anemic Solid Tumor Patients Receiving Concomitant Chemotherapy: A Prospective, Randomized, Controlled Study." Blood 118, no. 21 (2011): 2092. http://dx.doi.org/10.1182/blood.v118.21.2092.2092.

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Abstract Abstract 2092 Background: Erythropoiesis-stimulating agents (ESAs) are indicated for the management of chemotherapy induced anemia in oncology. However, increased risks of cardiovascular events, inferior survival, and poorer tumor outcomes are linked to ESAs when used to achieve a target hemoglobin ≥12 g/dL. Due to these serious safety concerns, the FDA has recommended more conservative dosing guidelines whereby the lowest possible dose of ESAs should be used to gradually increase hemoglobin concentration to the lowest level sufficient to avoid blood transfusion. The currently ASCO/AS
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47

Toma, Andrea, Sylvie Chevret, Olivier Kosmider, et al. "A randomized study of lenalidomide (LEN) with or without EPO in RBC transfusion dependent (TD) IPSS low and int-1 (lower risk) myelodysplastic syndromes (MDS) without del 5q resistant to EPO." Journal of Clinical Oncology 31, no. 15_suppl (2013): 7002. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.7002.

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7002 Background: ESAs, the first line treatments of anemia in non del 5q lower risk MDS, yield only 40-50% responses. LEN gives RBC transfusion independence (TI) in about 25% of ESA resistant (or relapsing) TD lower risk MDS without del 5q (Raza, Blood, 2008), and a gene expression signature can predict response (Ebert, Plos Med 2008). We randomized in this patient population LEN alone and LEN+EPO. Methods: In this prospective multicenter open-label phase II study (NCT01718379), lower risk MDS patients without del 5q, with TD (≥4 RBC units during the previous 8 weeks (w)) with ESA resistance o
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48

Derebail, Vimal K., Adam McDonald, and Julia Brittain. "Erythrocyte Adhesion in Hemodialysis Patients – A Novel Potential Contributor to Inflammation in End-Stage Renal Disease." Blood 120, no. 21 (2012): 2092. http://dx.doi.org/10.1182/blood.v120.21.2092.2092.

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Abstract Abstract 2092 Background: Widespread adhesion of erythrocytes in the vasculature would be incompatible with life. However, in illnesses such as sickle cell disease, malaria and diabetes, adhesive RBCs have been documented and are likely contributors to disease severity, inflammation and coagulation activation. End-stage renal disease is characterized by profound, global inflammation and relative thrombophilia. While we, and others, have reported the extensive exposure of RBC phosphatidylserine in patients on hemodialysis, the role of RBC adhesion in inflammation has never been examine
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49

Kiani, Soroosh, Mary-Lynn Brecht, Katherine Lovinger, and Robert S. Poston. "Managing Port-Site Bleeding during Less Invasive Coronary Artery Bypass Grafting." Heart Surgery Forum 15, no. 5 (2012): 272. http://dx.doi.org/10.1532/hsf98.20111179.

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<p><b>Introduction:</b> Robotic-assisted coronary artery bypass grafting (r-CABG) requires the placement of ports bluntly through the chest wall. When removed, these ports create bleeding sites that can be difficult to detect and treat. This study evaluated whether a topical hemostatic agent placed locally within these sites helps to reduce bleeding and blood product requirements.</p><p><b>Methods:</b> We retrospectively analyzed outcomes for r-CABG cases where 5 mL of a flowable hemostatic agent was injected locally within all port sites (hemostat gro
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50

Calvaresi, Emilia, and Jonathan Genzen. "Evaluating Percentage-Based Reporting of Glucose-6-Phosphate Dehydrogenase (G6PD) Enzymatic Activity in a National Reference Laboratory: Assessment of Patient Eligibility for Plasmodium vivax Radical Cure Therapy." American Journal of Clinical Pathology 152, Supplement_1 (2019): S82. http://dx.doi.org/10.1093/ajcp/aqz116.005.

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Abstract Objectives The World Health Organization recommends measurement of G6PD activity prior to initiation of 8-aminoquinolones for the treatment of P vivax malaria. An estimated 400 million people worldwide have G6PD deficiency, making them susceptible to hemolysis under oxidative stress. A new single-dose therapy (radical cure) for malaria with tafenoquine is contraindicated in patients with <70% normal G6PD activity due to its prolonged circulating half-life. However, most clinical laboratories report G6PD activity in units g/Hb or units/1012 RBC and do not provide percentage of norma
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