Siga este enlace para ver otros tipos de publicaciones sobre el tema: UCAF.
Artículos de revistas sobre el tema "UCAF"
Crea una cita precisa en los estilos APA, MLA, Chicago, Harvard y otros
Consulte los 50 mejores artículos de revistas para su investigación sobre el tema "UCAF".
Junto a cada fuente en la lista de referencias hay un botón "Agregar a la bibliografía". Pulsa este botón, y generaremos automáticamente la referencia bibliográfica para la obra elegida en el estilo de cita que necesites: APA, MLA, Harvard, Vancouver, Chicago, etc.
También puede descargar el texto completo de la publicación académica en formato pdf y leer en línea su resumen siempre que esté disponible en los metadatos.
Explore artículos de revistas sobre una amplia variedad de disciplinas y organice su bibliografía correctamente.
1
Fu, Jia-Wei, Yi-Sheng Lin, Sheng-Long Gan, Yong-Rui Li, Yao Wang, Shi-Ting Feng, Hao Li y Guo-Fu Zhou. "Multifunctionalized Microscale Ultrasound Contrast Agents for Precise Theranostics of Malignant Tumors". Contrast Media & Molecular Imaging 2019 (7 de julio de 2019): 1–18. http://dx.doi.org/10.1155/2019/3145647.
Texto completoResumen
In ultrasonography, ultrasound contrast agents (UCAs) that possess high acoustic impedance mismatch with the bulk medium are frequently employed to highlight the borders between tissues by enhanced ultrasound scattering in a clinic. Typically, the most common UCA, microbubble, is generally close in size to a red blood cell (<∼10 μm). These microscale UCAs cannot be directly entrapped into the target cells but generate several orders of magnitude stronger echo signals than the nanoscale ones. And their large containment and high ultrasound responsiveness also greatly facilitate to perform combined treatments, e.g., drug delivery and other imaging techniques. So multifunctionalized microscale UCAs appear on this scene and keep growing toward a promising direction for precise theranostics. In this review, we systematically summarize the new advances in the principles and preparations of multifunctionalized microscale UCAs and their medical applications for malignant tumors.
2
Jiang, Wangshu, Wimal Ubhayasekera, Melanie M. Pearson y Stefan D. Knight. "Structures of two fimbrial adhesins, AtfE and UcaD, from the uropathogenProteus mirabilis". Acta Crystallographica Section D Structural Biology 74, n.º 11 (29 de octubre de 2018): 1053–62. http://dx.doi.org/10.1107/s2059798318012391.
Texto completoResumen
The important uropathogenProteus mirabilisencodes a record number of chaperone/usher-pathway adhesive fimbriae. Such fimbriae, which are used for adhesion to cell surfaces/tissues and for biofilm formation, are typically important virulence factors in bacterial pathogenesis. Here, the structures of the receptor-binding domains of the tip-located two-domain adhesins UcaD (1.5 Å resolution) and AtfE (1.58 Å resolution) from twoP. mirabilisfimbriae (UCA/NAF and ATF) are presented. The structures of UcaD and AtfE are both similar to the F17G type of tip-located fimbrial receptor-binding domains, and the structures are very similar despite having only limited sequence similarity. These structures represent an important step towards a molecular-level understanding ofP. mirabilisfimbrial adhesins and their roles in the complex pathogenesis of urinary-tract infections.
3
Gurusamy, Umamaheswari, Ramya Thangavelu y Chaitra Venkataswamy. "Abnormalities of the umbilical cord: correlation with placental histology and perinatal outcome". International Journal of Research in Medical Sciences 5, n.º 11 (27 de octubre de 2017): 5009. http://dx.doi.org/10.18203/2320-6012.ijrms20174961.
Texto completoResumen
Background: The purpose of this study was to evaluate gross umbilical cord abnormalities and to examine its relationship with placental pathological features and perinatal outcome.Methods: We retrospectively collected 101 singleton placentas with gross umbilical cord abnormalities over 3-year period (delivered on or after 20 weeks of gestational age). Association between gross umbilical cord abnormalities such as hypercoiled cords, hypocoiled cords, thin cords, true knot, strictures, excessively long cord, and abnormal cord insertions were reviewed and evaluated for placental histology, clinical parameters and perinatal outcome.Results: The most common umbilical cord abnormality (UCA) observed was coiling abnormality (hypercoiling, hypocoiling and strictures). Gross UCAs were associated with maternal factors (preeclampsia, oligohydramnios and gestational diabetes), foetal factors (intrauterine foetal death, SGA and intrapartum complications such as NRFHR tracing and low Apgar scores) and histologic placental features (maternal vascular malperfusion, foetal vascular malperfusion, villous capillary lesions and inflammation). Cords with multiple abnormalities were significantly correlated with histologic evidence of foetal vascular obstruction and intrauterine foetal death.Conclusions: Gross UCAs, especially when multiple were associated with clinically significant placental findings and adverse perinatal outcome. Therefore, our study reinforces that all placentas with gross UCAs should be submitted for examination with complete (full length of the) umbilical cord.
4
Gupta, Ipshita, John R. Eisenbrey, Priscilla Machado, Maria Stanczak, Kirk Wallace y Flemming Forsberg. "On Factors Affecting Subharmonic-aided Pressure Estimation (SHAPE)". Ultrasonic Imaging 41, n.º 1 (12 de noviembre de 2018): 35–48. http://dx.doi.org/10.1177/0161734618812083.
Texto completoResumen
Subharmonic-aided pressure estimation (SHAPE) estimates hydrostatic pressure using the inverse relationship with subharmonic amplitude variations of ultrasound contrast agents (UCAs). We studied the impact of varying incident acoustic outputs (IAO), UCA concentration, and hematocrit on SHAPE. A Logiq 9 scanner with a 4C curvilinear probe (GE, Milwaukee, Wisconsin) was used with Sonazoid (GE Healthcare, Oslo, Norway) transmitting at 2.5 MHz and receiving at 1.25 MHz. An improved IAO selection algorithm provided improved correlations ( r from −0.85 to −0.95 vs. −0.39 to −0.98). There was no significant change in SHAPE gradient as the pressure increased from 10 to 40 mmHg and hematocrit concentration was tripled from 1.8 to 4.5 mL/L (Δ0.00-0.01 dB, p = 0.18), and as UCA concentration was increased from 0.2 to 1.2 mL/L (Δ0.02-0.05 dB, p = 0.75). The results for the correlation between the SHAPE gradient and hematocrit values for patients ( N = 100) in an ongoing clinical trial were also calculated showing a poor correlation value of 0.14. Overall, the SHAPE gradient is independent of hematocrit and UCA concentration. An improved algorithm for IAO selection will make SHAPE more accurate.
5
Silva, Jainy De Noronha, Sanny Aparecida Guimarães Souza, Igor Medeiros Vanderlei, Mariel José Pimentel de Andrade y Anderson Fernandes de Alencar. "INFORMÁTICA NA EDUCAÇÃO E FORMAÇÃO DE PROFESSORES(AS) DA REDE MUNICIPAL DE GARANHUNS - PE: UMA EXPERIÊNCIA EXTENSIONISTA". INTERNATIONAL JOURNAL EDUCATION AND TEACHING (PDVL) ISSN 2595-2498 3, n.º 2 (31 de agosto de 2020): 50–66. http://dx.doi.org/10.31692/2595-2498.v3i2.134.
Texto completoResumen
O presente trabalho apresenta resultados das atividades desenvolvidas até julho de 2019 no projeto de extensão “Informática, educação e acesso ao conhecimento: fomentando ensino com qualidade sociocultural e inclusão social nas escolas municipais de Garanhuns – PE”, cujo objetivo principal é contribuir para a efetiva utilização da informática na educação nas escolas públicas do município de Garanhuns (PE), bem como viabilizar a continuidade dos projetos de extensão ‘Tecnologias da informação, comunicação e educação: potencializando os processos de ensino e aprendizagem’ (2016), 'Informática e multimídia na educação básica: intensificando a presença de softwares livres com foco educacional no município de Garanhuns (PE)' (2017) e ‘Informática nas escolas municipais de Garanhuns (PE): propiciando formação, acesso e inclusão digital’ (2018). As atividades a serem explanadas tem enfoque no eixo formativo do projeto. No decorrer das ações desse eixo, de 2016 até atualmente, foram realizadas oficinas sobre o sistema operacional e os softwares educativos livres disponibilizados nos netbook do programa “Um Computador por Aluno” (UCA), onde professores, coordenadores, supervisores e gestores da rede municipal de ensino puderam participar. Neste ano de 2019, foi dado início às oficinas sobre o sistema operacional e os softwares educativos livres implantados nos laboratórios de informática das escolas municipais, onde foi possível concretizar as formações continuadas com foco nos desktop. No decorrer dessa ação formativa do projeto foi incentivada a elaboração de planos de aula para utilização dos softwares disponibilizados nos UCAs e desktop; e o envio dos planos para o ambiente virtual e disponibilização dos mesmos para toda a comunidade. Considerando as ações já finalizadas e as que estão em andamento, avançamos consideravelmente quanto a melhorias no âmbito da informática aplicada à educação na rede municipal de Garanhuns, continuamos em atividades neste segundo semestre para desenvolver 3 formações, dentre elas: uso do laboratório de informática, uso dos software livres disponibilizados nos UCAs, metodologias de ciências e informática e uma formação sobre pensamento computacional; publicação dos guias de uso dos softwares livres disponibilizados nos netbook do programa UCA e nos computadores de mesa (desktop) das escolas municipais, e o acompanhamento do uso dos UCAs e dos desktop.
6
Lin, Mingtuan, Yue Gao, Peiguo Liu y Zhiqing Guo. "Performance Analyses of the Radio Orbital Angular Momentum Steering Technique Based on Ka-Band Antenna". International Journal of Antennas and Propagation 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/8050652.
Texto completoResumen
The misalignment in the orbital angular momentum- (OAM-) based system would distort the radiation patterns of twisted beams carrying OAM, consequently making the OAM-based communication infeasible. To tackle the misalignment problem, a radio OAM steering technique based on a uniform circular array (UCA) is illustrated. Subsequently, simulations are conducted to explore the influence of the OAM steering on the OAM mode quality and transmission performance. Furthermore, UCAs working at Ka-band with formulated feeding networks are designed and fabricated to analyze the performance of the OAM steering. The influences of OAM steering on mode quality and orthogonality are then evaluated in the experiment. Overall, the analyses of OAM steering technique are beneficial for the development of radio OAM study.
7
Hu, Yinfeng, Shengmin Zhang, Minhua Guo, Fei Yu, Jun Huang, Youfeng Xu y Sheng Zhu. "Preparation of Lipid Nano-Bubbles as Contrast Agent Material for Tumor Ultrasound Diagnosis of Breast Cancer". Science of Advanced Materials 12, n.º 8 (1 de agosto de 2020): 1184–93. http://dx.doi.org/10.1166/sam.2020.3819.
Texto completoResumen
Ultrasound diagnostic technology has higher application values in tumor diagnosis due to its higher spatial resolution and no radiation. Ultrasound lipid nanobubble contrast material can further improve the accuracy of tumor diagnosis. Therefore, the liposomes were used as shells to encapsulate bio-inert gases to prepare nano-scale microbubbles NBs. Meanwhile, the Annexin V molecules were connected through the conjugation of biotin-avidin to prepare targeted nano-scale ultrasound contrast agents (UCAs) Annexin V-Nanobubbles (AVNBs). The tumor-bearing mice apoptosis models were constructed by injecting human breast cancer MDA-MB231 cells, and the nano-scale UCA AV-NBs was used for ultrasound diagnosis, data collection, and statistical analysis. The results showed that the prepared AV-NBs were nano-sized hollow spheres with relatively stable particle size, zeta potential, and excellent stability. By verifying the constructed mice apoptosis models, it was found that mice heterotopic transplantation tumor apoptosis models were successfully constructed. When the mice models were observed by ultrasound, the apoptosis index of the cell was found to be positively correlated with the enhancement degree of the image. Therefore, the enhancement effect of the targeted UCA AV-NBs was obvious. The AV-NBs could be specifically targeted to the apoptotic region of tumor tissue in vivo, which was also slightly enriched in the liver and kidney. Therefore, the experiment found that the targeted nano-scale UCA AV-NBs combined with ultrasound detection could significantly enhance the diagnostic accuracy of breast cancer tumors, which provided the experimental evidence for early tumor diagnosis and evaluation.
8
Miyachi, Hiroshi, Kohei Suzuki, Shohei Nagasaka, Takehiro Kitagawa y Junkoh Yamamoto. "Brain ischemia due to direct vascular compression associate with rapid enlargement of unruptured middle cerebral artery aneurysm: A case report". Surgical Neurology International 12 (24 de marzo de 2021): 115. http://dx.doi.org/10.25259/sni_843_2020.
Texto completoResumen
Background: Acute cerebral infarction is a rare complication resulting from an unruptured cerebral aneurysm (UCA). There is presently no consensus on the optimal strategy for the management of UCAs with cerebral infarctions. Case Description: A 53-year-old man presented with transient dysarthria and left hemiparesis. Magnetic resonance imaging (MRI) demonstrated the presence of a 7 mm UCA originating from the middle cerebral artery bifurcation, and diffusion-weighted imaging showed no evidence of cerebral infarction. One month later, his transient left hemiparesis recurred, and the patient was admitted to our hospital. Computed tomography angiography showed enlargement of the aneurysm. His left hemiparesis worsened 3 days later. MRI showed cerebral infarction in the area of perforating arteries and further enlargement of the aneurysm with surrounding parenchymal edema. Therefore, the rupture risk was considered to be rarely high and dome clipping was performed immediately. Postoperatively, his neurological status improved without any recurrent brain ischemia. Conclusion: We report a rare case of a rapidly enlarging aneurysm that presented with cerebral infarction. This is the first report describing aneurysmal sac enlargement that can lead to perforating artery obstruction and brain ischemia. The case illustrates the importance of performing close follow-up examinations to confirm findings that suggest a high rupture risk.
9
Li, Hui-Jin, Xiao-Min Sun, Zheng-Kun Li, Qian-Wen Yin, Huan Pang, Jing-Jing Pan, Xu Li y Wei Chen. "LncRNA UCA1 Promotes Mitochondrial Function of Bladder Cancer via the MiR-195/ARL2 Signaling Pathway". Cellular Physiology and Biochemistry 43, n.º 6 (2017): 2548–61. http://dx.doi.org/10.1159/000484507.
Texto completoResumen
Background/Aims: This study aims to identify whether Urothelial Cancer Associated 1 (UCA1) regulates mitochondrial metabolic reprogramming in bladder cancer, and to explore how UCA1 participates in mitochondrial metabolism by the UCA1/miR-195/ARL2 signaling pathway; these findings may be aid in the development of tumor diagnostic and therapeutic strategies. Methods: Bladder tissues were obtained from patients. Stable cell lines were constructed, with ectopic expression of UCA1 in UMUC2 cells and knockdown of UCA1 in 5637 cells. The expression levels of UCA1, miR-195, and ARL2 were detected by real-time PCR, western blotting, and immunohistochemistry Cell viability was detected by Cell Counting Kit-8 (CCK8) assay; mitochondrial DNA copy numbers were tested by realtime PCR; ATP level was evaluated by ATP assay kit; mitochondrial membrane potential was analyzed by 5,5’,6,6’-tetrachloro-1,1’,3,3’- tetraethylbenzimidazolylcarbocyanine iodide (JC-1) fluorescent probe. miRNAs between UCA1 and ARL2 were predicted by TargetScan and RNAHybrid, and then determined by real-time PCR. Dual-luciferase activity assay and RNA immunoprecipitation (RIP) assay were used to verify the relationship between UCA1 and miR-195. The expression level of ARL2 was silenced by small interfering RNA(siRNA). For in vivo experiments, UCA1-silencing 5637 cells were subcutaneously injected into BALB/C nude mice to evaluate the effects of UCA1 on tumor progression by the regulation of miR-195 and ARL2. Results: We demonstrate here that UCA1 enhances mitochondrial function in bladder cancer cells. UCA1 contributes to ARL2-induced mitochondrial activity, which plays an important role in mitochondrial function. UCA1, as a competing endogenous RNA (ceRNA), regulates mitochondrial function through upregulating ARL2. In this way, it inhibited the miR-195 signaling pathway to enhance mitochondrial function in bladder cancer. Additionally, ARL2 is a direct target of miR-195 and can be repressed by either miR-195 overexpression or UCA1 inhibition. Knockdown of ARL2 was analogous to the inhibition of UCA1 and the upregulation of miR-195. Animal experiments further indicated that UCA1 promoted bladder tumor growth by regulating miR-195 /ARL2. Conclusion: These data suggest that UCA1 enhanced mitochondrial function and cell viability through the UCA1/miR-195/ARL2 axis in vitro and in vivo. The elucidation of this signaling network provides a more adequate theoretical basis for understanding the molecular pathology of bladder cancer, and also UCA1 as a potential diagnosis and treatment target for bladder cancer.
10
Chen, Xia y Zhen Yu Lu. "A Study on UCAV Targets Assignment Based on Consensus Uncertain Detecting Information". Advanced Materials Research 503-504 (abril de 2012): 1235–38. http://dx.doi.org/10.4028/www.scientific.net/amr.503-504.1235.
Texto completoResumen
UCAV targets assignment is a key research topic in UCAV formation mission planning area. As UCAV targets assignment problem under uncertain detecting information, a new method is proposed in this paper. Firstly, the UCAV targets assignment problem under uncertain dectection information is described. Then, the mathematical model of UCAV targets assignment under uncertain detecting information is established and UCAV targets assignment with SMAA method based on uncertain detecting information is given after introducing the SMAA method. Finally, simulations are presented to demonstrate the effectiveness of this method.
11
Li, Yucheng, Jiang Xin y Wencai Sun. "LncRNA Urothelial Carcinoma-Associated 1 (UCA1) Regulates Rat Bone Marrow Mesenchymal Stem Cell Differentiation and Promotes Repair of Bone Defects". Journal of Biomaterials and Tissue Engineering 9, n.º 10 (1 de diciembre de 2019): 1441–47. http://dx.doi.org/10.1166/jbt.2019.2145.
Texto completoResumen
Bone marrow mesenchymal stem cells (BMSCs) have characteristics of self-renewal and multidirectional differentiation. LncRNA UCA1 regulates BMSCs differentiation. Whether LncRNA UCA1 plays a role in bone defects remains unclear. BMSCs were randomly divided into control group, radiation group (6Gy), radiation + UCA1 group followed by analysis of the expression of LncRNA UCA1, RUNX2 and OPN by real time PCR, BMSCs proliferation by MTT assay as well as ALP activity. Healthy Sprague-Dawley rats were randomly divided into control group; bone defect group; UCA1 group, in which UCA1-transfected BMSCs were infused into bone defect rats followed by analysis of bone mineral density, ALP activity as well as the formation of type II collagen by ELISA. LncRNA UCA1 expression was significantly decreased in BMSCs of irradiated group, with decreased BMSCs proliferation, reduced expression of RUNX2 and OPN as well as decreased ALP activity (P < 0.05). Transfection of UCA1 significantly up-regulated LncRNA UCA1 expression in BMSCs, promoted BMSCs proliferation, increased the expression of RUNX2 and OPN, and the activity of ALP (P < 0.05). In addition, UCA1 promoted bone mineral density, increased ALP activity and type II collagen formation in rats with bone defect. LncRNA UCA1 promotes osteogenic differentiation of BMSCs, and targeting it might be a novel approach to promote bone remodeling at the bone defect site.
12
Zhou, Xiao Cheng, Cun Ren Wang y Jian Gang Yan. "Research on UCAV Efficiency Evaluation Method". Advanced Materials Research 562-564 (agosto de 2012): 2145–48. http://dx.doi.org/10.4028/www.scientific.net/amr.562-564.2145.
Texto completoResumen
UCAV will play a more and more important role in future fight. UCAV efficiency evaluation method is still in the developing stage. UCAV fight elements are analyzed that include reconnaissance elements and attacking to ground elements. Basing on analysis of UCAV reconnaissance efficiency and attacking ground efficiency, UCAV reconnaissance efficiency model and attacking ground efficiency model are constructed. The feasibility and validity of model is validated by arithmetic example.
13
Wang, Yuan-Hang, Fang Wang, Lan Zhang y Jia-Chun Lu. "Long non-coding RNA UCA1 can predict tumor lymph node metastasis". Tumor Biology 39, n.º 5 (mayo de 2017): 101042831770620. http://dx.doi.org/10.1177/1010428317706208.
Texto completoResumen
Numerous studies suggested that long non-coding RNA UCA1 was highly expressed and played critical roles in the development and progression of various cancerous tissues and cells. However, little is known about the association between UCA1 and tumor lymph node metastasis. In our study, a systematic review was conducted to evaluate the association between UCA1 expression and tumor lymph node metastasis and explore whether UCA1 can be a potential molecular marker for predicting the multiple tumor lymph node metastasis. The meta-analysis result showed that the number of lymph node metastasis in different tumorous types of UCA1 high-expression group was significantly higher compared with UCA1 low-expression group (pooled odds ratio = 2.13, 95% confidence interval: 1.60–2.84, p < 0.05). To verify whether the above result was still valid in specific tumor type, we conducted a meta-analysis including four articles on colorectal cancer (pooled odds ratio = 2.07, 95% confidence interval: 1.28–3.34, p < 0.05). Based on the existing results, it can be explained that the long non-coding RNA UCA1 was significantly associated with lymph node metastasis and both the results revealed that compared with UCA1 low-expression group, the lymph node metastasis rate of UCA1 high-expression group was statistically significantly elevated. Therefore, long non-coding RNA UCA1 has the potential of being a biological marker for predicting lymph node metastasis.
14
Liu, Hai-E., Hao-Hong Shi y Xing-Jing Luo. "Upregulated Long Noncoding RNA UCA1 Enhances Warburg Effect via miR-203/HK2 Axis in Esophagal Cancer". Journal of Oncology 2020 (4 de noviembre de 2020): 1–11. http://dx.doi.org/10.1155/2020/8847687.
Texto completoResumen
Reprogrammed glucose metabolism of enhanced aerobic glycolysis, also known as Warburg effect, which exerts a significant contributor to cancer progression, is regarded as a hallmark of cancer. The roles of long noncoding RNAs (lncRNA) in regulating cancer via metabolic reprogramming are mostly unknown, including esophagal cancer (EC). Here, we showed that how the lncRNA urothelial carcinoma associated 1 (UCA1) exerts pro-oncogene in regulating EC glucose metabolism. Firstly, we found that upregulated UCA1 expression enhances the malignant phenotypes of EC, including poor outcome, larger tumor size, positive lymphatic invasion, and advanced pathological stages. UCA1 silencing could suppress EC cell proliferation and metastasis. Following, bioinformatics analyses revealed that UCA1 regulated the HK2 expression through functioning as a competing endogenous RNA (ceRNA). Mechanistically, UCA1 overexpression could elevate the activation of HK2 oncogenes via inhibition of miR-203 activity, as evidenced by the positive correlation of UCA1 with HK2 and inverse correlation with miR-203 expression. Luciferase activity assay further verified the targeting relationship between UCA1, miR-203, and HK2. Upregulated UCA1 in EC cells significantly suppressed the degradation of HK2 by miR-203. Further research showed that upregulated UCA1 effectively increased the rate of glucose uptake, lactate output, and ECAR value, all of which can be attenuate by HK2 interference and 2-DG, whereas knockdown of UCA1 had the opposite effect. In sum, our findings suggest that the UCA1/miR-203/HK2 axis contributes to EC development by reprogramming tumor glucose metabolism, providing new insight into the management of EC patients.
15
Choudhry, Hani. "UCA1 Overexpression Promotes Hypoxic Breast Cancer Cell Proliferation and Inhibits Apoptosis via HIF-1α Activation". Journal of Oncology 2021 (7 de mayo de 2021): 1–8. http://dx.doi.org/10.1155/2021/5512156.
Texto completoResumen
The noncoding RNA termed urothelial carcinoma-associated 1 (UCA1) is an oncogenic lncRNA involved in promoting the growth of several tumors through various pathways. The aim of this study was to explore the expression of UCA1 in hypoxic breast cancer and its impact on tumorigenesis in low levels of oxygen. Here, we show that UCA1 is upregulated in a number of hypoxic (1% O2) breast cancer cells. In addition, UCA1 expression is significantly overexpressed in breast cancer tissues compared to matched normal cells. UCA1 knockdown in hypoxia inhibits breast cancer proliferation and induces apoptosis. The knockdown of hypoxia-inducible transcription factor 1α (HIF-1α) but not HIF-2α significantly decreases the expression of UCA1 in hypoxia. Overall, these findings indicate that UCA1 is a hallmark of hypoxic breast cancer and its expression is positively regulated by HIF-1α.
16
Li, Qiang, Wanying Xing, Xilong Gong y Yueshu Wang. "Long Non-Coding RNA Urothelial Carcinoma Associated 1 Promotes Proliferation, Migration and Invasion of Osteosarcoma Cells by Regulating microRNA-182". Cellular Physiology and Biochemistry 51, n.º 3 (2018): 1149–63. http://dx.doi.org/10.1159/000495493.
Texto completoResumen
Background/Aims: Previous studies demonstrated the oncogenic roles of lncRNA UCA1 in osteosarcoma. This study aimed to explore the internal molecular mechanism of UCA1 on promoting osteosarcoma cell proliferation, migration and invasion. Methods: qRT-PCR was conducted to measure the expression levels of UCA1, miR-182 and TIMP2. Cell transfection was used to change the expression levels of UCA1, miR-182 and TIMP2. Cell viability, migration, invasion and apoptosis were measured using CCK-8 assay, two-chamber migration (invasion) assay and Guava Nexin assay, respectively. The associations between UCA1, miR-182 and iASPP were analyzed by dual luciferase activity assay. The protein expression levels of key factors involved in cell apoptosis, PI3K/AKT/GSK3β pathway and NF-κB pathway, as well as p53, Rb, RECQ family and iASPP were evaluated by western blotting. Results: UCA1 was highly expressed in osteosarcoma MG63 and OS-732 cells. Knockdown of UCA1 inhibited OS-732 cell viability, migration and invasion, but promoted cell apoptosis. miR-182 was up-regulated in OS-732 cells after UCA1 knockdown and participated in the effects of UCA1 on OS-732 cells. TIMP2 was downstream factor of miR-182 and involved in the regulatory roles of miR-182 on OS-732 cell viability, migration, invasion, apoptosis, as well as PI3K/AKT/GSK3β and NF-κB pathways. UCA1 knockdown up-regulated p53, Rb and RECQL5 levels in OS-732 cells, while down-regulated the expression of iASPP. TGF-β or TNF-α treatment could enhance the expression of UCA1 in OS-732 cells. Conclusion: Our research verified that UCA1 exerted oncogenic roles in osteosarcoma cells by regulating miR-182 and TIMP2, as well as PI3K/AKT/GSK3β and NF-κB pathways.
17
Huang, Huan, Zhengyan Zhu y Yu Song. "Downregulation of lncrna uca1 as a diagnostic and prognostic biomarker for ovarian endometriosis". Revista da Associação Médica Brasileira 65, n.º 3 (marzo de 2019): 336–41. http://dx.doi.org/10.1590/1806-9282.65.3.336.
Texto completoResumen
SUMMARY OBJECTIVE: Ovarian endometriosis seriously affects the quality of life of females, and long non-coding RNA lncRNA urothelial carcinoma-associated 1 (UCA1) plays pivotal roles in the pathogenesis of various ovarian diseases. However, the involvement of lncRNA UCA1 in ovarian endometriosis remains unknown to date. Therefore, the present study aims to study the role of UCA1 in ovarian endometriosis. METHODS: A total of 98 patients with ovarian endometriosis and 28 healthy females were included. The expression of lncRNA UCA1 in ectopic and eutopic endometrium tissues of ovarian endometriosis patients and controls was detected using qRT-PCR. A ROC curve analysis was performed to evaluate the diagnostic values of serum lncRNA UCA1 for ovarian endometriosis. Patients were followed up for 2 years after discharge, and the recurrence of ovarian endometriosis was recorded. RESULTS: The expression level of lncRNA UCA1 was significantly higher in ectopic endometrium tissues than in paired eutopic endometrium tissues for most of the patients. The serum lncRNA UCA1 level showed no significant correlations with either patients’ age or living habits. After the treatment, the serum lncRNA UCA1 level increased, and serum levels of lncRNA UCA1 on the day of discharge were significantly lower in patients with recurrence than those in patients without recurrence. Conclusion: The downregulation of lncRNA UCA1 is involved in the pathogenesis of ovarian endometriosis and may serve as a promising diagnostic and prognostic biomarker for the disease.
18
Wang, Cun Ren, Xiao Cheng Zhou y Jian Gang Yan. "Research on UCAV Efficiency Evaluation System Based on VxWorks". Advanced Materials Research 562-564 (agosto de 2012): 1702–5. http://dx.doi.org/10.4028/www.scientific.net/amr.562-564.1702.
Texto completoResumen
UCAV efficiency evaluation system is used to evaluate the UCAV efficiency index and show the evaluation conclusions. The evaluation system is studied based on VxWorks that has high reliability and good real time character. The UCAV efficiency indexes are analyzed on this paper first. Then system function, system configuration and operating system are discussed. The key points of the system are also analyzed on this paper. At last, the collectivity designing mind of UCAV efficiency evaluation system is acquired. The system can finish the task of UCAV efficiency evaluation under the complex battle circumstance.
19
&NA;. "UCSF study". Orthopaedic Nursing 15, n.º 4 (julio de 1996): 64. http://dx.doi.org/10.1097/00006416-199607000-00014.
Texto completo
20
Sun, Yang, Jun-Gong Jin, Wei-Yang Mi, Hao-Wu, Shi-Rong Zhang, Qiang Meng y Shi-Tao Zhang. "Long Noncoding RNA UCA1 Targets miR-122 to Promote Proliferation, Migration, and Invasion of Glioma Cells". Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 28, n.º 6 (16 de marzo de 2020): 683–84. http://dx.doi.org/10.3727/096504021x16137463165433.
Texto completoResumen
Originally published in Volume 26, No. 1, pages 103–110, 2018 (doi:https://doi.org/10.3727/096504017X14934860122864) Glioma is the most common and lethal malignant intracranial tumor. Long noncoding RNAs (lncRNAs) have been identified as pivotal regulators in the tumorigenesis of glioma. However, the role of lncRNA urothelial carcinoma-associated 1 (UCA1) in glioma genesis is still unknown. The purpose of this study was to investigate the underlying function of UCA1 on glioma genesis. The results demonstrated that UCA1 was upregulated in glioma tissue and indicated a poor prognosis. UCA1 knockdown induced by si-UCA1 significantly suppressed the proliferative, migrative, and invasive activities of glioma cell lines (U87 and U251). Bioinformatics analysis and luciferase reporter assay verified the complementary binding within UCA1 and miR-122 at the 3′-UTR. Functional experiments revealed that UCA1 acted as an miR-122 “sponge” to modulate glioma cell proliferation, migration, and invasion via downregulation of miR-122. Overall, the present study demonstrated that lncRNA UCA1 acts as an endogenous sponge of miR-122 to promote glioma cell proliferation, migration, and invasion, which provides a novel insight and therapeutic target in the tumorigenesis of glioma.
21
Zhu, Genglong, Xialei Liu, Yonghui Su, Fangen Kong, Xiaopeng Hong y Zhidong Lin. "Knockdown of Urothelial Carcinoma-Associated 1 Suppressed Cell Growth and Migration Through Regulating miR-301a and CXCR4 in Osteosarcoma MHCC97 Cells". Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 27, n.º 1 (27 de diciembre de 2018): 55–64. http://dx.doi.org/10.3727/096504018x15201143705855.
Texto completoResumen
Liver cancer is one of the most common malignancies in the world and a leading cause of cancer-related mortality. Accumulating evidence has highlighted the critical role of long noncoding RNAs (lncRNAs) in various cancers. The present study aimed to explore the role of lncRNA urothelial carcinoma-associated 1 (UCA1) in cell growth and migration in MHCC97 cells and its underlying mechanism. First, we assessed the expression of UCA1 in MHCC97 and three other cell lines by RT-qPCR. Then the expression of UCA1, miR-301a, and CXCR4 in MHCC97 cells was altered by transient transfection. The effects of UCA1 and miR-301 on cell viability, migration, invasion, and apoptosis were assessed. The results revealed that UCA1 expression was relatively higher in MHCC97 cells than in MG63, hFOB1.19, and OS-732 cells. Knockdown of UCA1 reduced cell viability, inhibited migration and invasion, and promoted cell apoptosis. However, the effect of UCA1 knockdown on cell growth and migration was blocked by miR-301a overexpression, whose expression was regulated by UCA1. We also found that miR-301a positively regulated CXCR4 expression. CXCR4 inhibition reversed the effect of miR-301a overexpression on cell growth and migration. Moreover, miR-301a activated the Wnt/β-catenin and NF-κB pathways via regulating CXCR4. The present study demonstrated that UCA1 inhibition exerted an antigrowth and antimigration role in MHCC97 cells through regulating miR-301a and CXCR4 expression.
22
Yin, Dexin, Changgeng Fu y Dajun Sun. "Silence of lncRNA UCA1 Represses the Growth and Tube Formation of Human Microvascular Endothelial Cells Through miR-195". Cellular Physiology and Biochemistry 49, n.º 4 (2018): 1499–511. http://dx.doi.org/10.1159/000493454.
Texto completoResumen
Background/Aims: Recent studies have suggested that several lncRNAs contribute to the angiogenic function of endothelial cells. Herein, we set out to reveal whether lncRNA UCA1 has functions in endothelial angiogenesis. Methods: The expression levels of lncRNA UCA1, miR-195 and CCND1 in human microvascular endothelial HMEC-1 cells were altered by transfection. Subsequently, cell viability, migration, tube formation and apoptosis of HMEC-1 cells were respectively assessed. The cross-talk between lncRNA UCA1, miR-195, CCND1, and MEK/ERK and mTOR signaling pathways were investigated by performing qRT-PCR and Western blotting. Results: Silence of lncRNA UCA1 repressed HMEC-1 cells viability, migration, tube formation, and induced apoptosis. Meanwhile, silence of lncRNA UCA1 significantly up-regulated miR-195 expression. These alterations induced by lncRNA UCA1 were further enhanced by miR-195 overexpression, while were attenuated by miR-195 suppression. Moreover, silence of lncRNA UCA1 deactivated MEK/ERK and mTOR signaling pathways via a miR-195-dependent regulation. And the deactivation of MEK/ERK and mTOR signaling pathways led to a down-regulation of CCND1. Conclusion: This study demonstrates that silence of lncRNA UCA1 largely represses microvascular endothelial cells growth and tube formation. Silence of lncRNA UCA1 exerts its function possibly via up-regulation of miR-195, which in turn inactivates MEK/ERK and mTOR signaling pathways, and ultimately represses CCND1 expression.
23
Yan, Youyou, Bin Zhang, Ning Liu, Chao Qi, Yanlong Xiao, Xin Tian, Tianyi Li y Bin Liu. "Circulating Long Noncoding RNA UCA1 as a Novel Biomarker of Acute Myocardial Infarction". BioMed Research International 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/8079372.
Texto completoResumen
Acute myocardial infarction (AMI) is the most serious cardiovascular disease with high morbidity and mortality. Recent studies have showed that long noncoding RNAs (lnc RNA) play important roles in pathophysiology of cardiovascular diseases, but the investigations are still in their infancy. An lnc RNA named urothelial carcinoma-associated 1 (UCA1) is found in tumors such as bladder cancers and lung cancer. And the UCA1 could be as a predictive biomarker for bladder cancer in urine samples or lung cancer in plasma, respectively. In normal states, UCA1 is specifically expressed in heart of adult, indicating that UCA1 might be as a biomarker for heart diseases such as AMI. To test the speculation, we detect the level of UCA1 in plasma of AMI patients and health control using quantitative reverse transcription-polymerase chain reaction (qRT-PCR). In addition, we also test the level of miR-1 as it is reported to regulate the expression of UCA1. The results show that the level of plasma UCA1 is decreased at the early state of AMI patients and increased at day 3 after AMI. In addition, the UCA1 alteration is inversely associated with the expression of miR-1. These findings indicate that the circulating UCA1 could be used as a promising novel biomarker for the diagnosis and/or prognosis of AMI.
24
Hisabe, Takashi, Toshiyuki Matsui, Kazutomo Yamasaki, Tsuyoshi Morokuma, Kenmei Aomi, Naoyuki Yoshizawa, Noritaka Takatsu et al. "Possible Earlier Diagnosis of Ulcerative Colitis-Associated Neoplasia: A Retrospective Analysis of Interval Cases during Surveillance". Journal of Clinical Medicine 10, n.º 9 (29 de abril de 2021): 1927. http://dx.doi.org/10.3390/jcm10091927.
Texto completoResumen
Background: Early detection of ulcerative colitis-associated neoplasia (UCAN) is often difficult. The aim of this study was to clarify the morphology of initial UCAN. Methods: White-light colonoscopy images obtained within the 2 years before UCAN diagnosis were retrospectively reviewed. The primary endpoint was the frequency of visible or invisible neoplasia on the endoscopic images before UCAN diagnosis. The secondary endpoints were comparisons of (1) visible or invisible neoplasia on initial endoscopic images of early-stage and advanced cancers, (2) the clinical backgrounds of patients in whom neoplasia was visible or invisible on initial endoscopic images, and (3) the clinical backgrounds of patients with distinct and indistinct UCAN borders. Results: Of the 27 UCAN lesions (11 early-stage; 16 advanced-stage), 25.9% (n = 7) were initially visible and 74.1% (n = 20) were invisible. The mean interval between the last surveillance colonoscopy and UCAN diagnosis was 14.5 ± 6.7 months. Of early-stage cancers, 18.2% (n = 2) were visible and 81.8% (n = 9) were invisible. Of advanced-stage cancers, 31.3% (n = 5) were visible and 68.8% (n = 11) were invisible. Invisible lesions were significantly more common in the rectum (p = 0.011) and tended to be more common in patients with inflammation and left-sided colitis (p = 0.084, p = 0.068, respectively). Patients with indistinct UCAN borders were significantly more likely to present with inflammation than those with distinct UCAN borders (p = 0.021). Conclusion: More careful surveillance is needed because rectum lesions and inflammation are difficult to identify as neoplasia even within the 2 years before a UCAN diagnosis.
25
Matsui, Akira, Shu Hoteya, Junnosuke Hayasaka, Satoshi Yamashita, Yorinari Ochiai, Yugo Suzuki, Yumiko Fukuma et al. "Real-World Experience of Endoscopic Submucosal Dissection for Ulcerative Colitis-Associated Neoplasia". Inflammatory Intestinal Diseases 6, n.º 2 (2021): 70–77. http://dx.doi.org/10.1159/000512292.
Texto completoResumen
<b><i>Introduction:</i></b> Patients with ulcerative colitis (UC) have an increased risk of colorectal cancer. Some studies have recently investigated endoscopic resection of UC-associated neoplasia (UCAN), but the indications for endoscopic resection of UCAN remain controversial. This study sought to clarify the problems encountered in endoscopic submucosal dissection (ESD) for UCAN. <b><i>Methods:</i></b> Seventeen lesions in 12 patients with UCAN (UCAN group) and 913 epithelial lesions in 824 control patients without UC (non-UC group) were evaluated. Both groups underwent ESD between January 2010 and December 2017 at Toranomon Hospital, Tokyo, Japan. Treatment outcomes of the 2 groups were compared retrospectively. <b><i>Results:</i></b> Univariate analysis showed that the mean tumor size was significantly smaller in the UCAN group than in the non-UC group (25.1 ± 26.7 mm vs. 31.9 ± 19.0; <i>p</i> = 0.0023); however, the R0 resection rate was significantly lower in the UCAN group (70.6 vs. 92.9%; <i>p</i> = 0.001). Multivariate analysis showed a significantly lower negative horizontal margin rate in the UCAN group (odds ratio 11.3, 95% confidence interval 3.588–34.525; <i>p</i> = 0.000). <b><i>Discussion/Conclusion:</i></b> ESD for UCAN is associated with a low-negative horizontal margin rate. When performing ESD for UCAN, it is important to evaluate the accuracy of the UCAN demarcation line, especially for flat lesions, using white-light imaging and chromoendoscopy as well as other modalities, including biopsy of surrounding tissues.
26
Zheng, Zhi-kun, Cui Pang, Yang Yang, Qiong Duan, Ju Zhang y Wen-chao Liu. "Serum long noncoding RNA urothelial carcinoma-associated 1: A novel biomarker for diagnosis and prognosis of hepatocellular carcinoma". Journal of International Medical Research 46, n.º 1 (31 de agosto de 2017): 348–56. http://dx.doi.org/10.1177/0300060517726441.
Texto completoResumen
Objective Long noncoding RNAs (lncRNAs) offer great potential as cancer biomarkers. This study was performed to assess the applicability of serum lncRNA urothelial carcinoma-associated 1 (UCA1) as a diagnostic and/or prognostic biomarker for hepatocellular carcinoma (HCC). Methods We examined UCA1 expression in serum samples from 105 patients with HCC, 105 patients with benign liver disease (BLD), and 105 healthy volunteers using reverse-transcription polymerase chain reaction and analyzed the relationship between serum UCA1 and clinicopathological parameters of HCC as well as survival. Results Expression of serum UCA1 was significantly higher in patients with HCC and allowed for discrimination of HCC from BLD and healthy controls. High expression of serum UCA1 was significantly associated with a high tumor grade, large tumor size, positive vascular invasion, and advanced TNM stage. Multivariate analysis revealed that a high serum UCA1 level was an independent unfavorable prognostic factor for HCC. Conclusions Our results confirm the upregulation of serum UCA1 expression in HCC and indicate its clinical value as a noninvasive biomarker for HCC screening and prognostic prediction.
27
Yi, Shen, Ying Xiao-jiang, Li Zhen-jun, Li Gang, Xue Wu-jin y Jie Wei-xia. "UCA1, a long noncoding RNA, promotes the proliferation of CRC cells via p53/p21 signaling". Open Life Sciences 11, n.º 1 (1 de enero de 2016): 206–10. http://dx.doi.org/10.1515/biol-2016-0027.
Texto completoResumen
AbstractObjectiveRecently, the role of long noncoding RNAs (lncRNAs) in human colorectal cancer (CRC) has been a subject of intense focus. We set out to determine the function of one lncRNA, termed urothelial carcinoma-associated 1 (UCA1) in CRC cell proliferation and its underlying mechanisms.MethodsQuantitative real-time PCR (qRT-PCR) was applied to detect the expression level of UCA1 in 50 pairs of CRC samples compared with non-tumor colon tissues. Cell growth was determined using the Cell Counting Kit-8 (CCK-8). Western blotting was carried out to analyze the related protein expression. Flow cytometry was done to evaluate cell apoptosis by UCA1 inhibition.ResultsWe found an increased expression of UCA1 in CRC samples. Knockdown of UCA1 in HCT116 cells induced a decrease in cell proliferation rate compared to control samples. This oncogenic activity may be enhanced through p53/ p21 signaling.ConclusionOur results supported the hypothesis that upregulation of UCA1 contributes to the unlimited proliferation rate of CRC cells, at least partially through the negative regulation of p53/p21 signaling pathway. Finally, we found that UCA1 merely influenced CRC cell apoptosis.
28
Perez-Ema, Natalia y Monica Alvarez de Buergo. "Evaluation of Multi-Functional Silica-Based Nano-Products for Consolidating and Protecting Stone Material from Archaeological Sites". Solid State Phenomena 286 (enero de 2019): 95–104. http://dx.doi.org/10.4028/www.scientific.net/ssp.286.95.
Texto completoResumen
A silica-based nanoproduct - UCAT-10P© - developed and patented by the TEP-243 (Molecular sieves and other nanomaterials) group of the Cadiz University (UCA) is applied on two stone materials – granite and marble – from the stage front of the Roman theater of Merida, World Heritage by UNESCO (1993). Marble shows firstly scaling as the main decay form, and granite, grain-disintegration, which, at the same time, favor an acceleration of their deterioration condition due to physical, mechanical, chemical and biological processes. That is the reason of assessing the efficiency and durability of a multifuncional nanoproduct, with both consolidating and hydrophobing effects. The performance of this product has been evaluated in terms of the appearance of the stone surfaces (color and roughness), the consolidating role (hardness and ultrasound velocity) and the hydrophobing achievements (capillarity and water contact angle). The most distinctive feature of this research is the in situ testing of the stone blocks, the use of mostly non-destructive and portable techniques, and the monitoring of the product performance of the treatment at a short (1 month) and mid-term (12-15 months), proving the efficacy of the product, although its behavior changes with time.
29
Xu, Xiaoying, Yufang Zhang, Jing Li y Baohong Mao. "Urothelial cancer associated 1 (UCA1) regulates trophoblast viability, proliferation, and migration via modulating the UCA1/miR-455/RUNX2 signaling pathway". Acta Biochimica et Biophysica Sinica 52, n.º 10 (octubre de 2020): 1120–30. http://dx.doi.org/10.1093/abbs/gmaa096.
Texto completoResumen
Abstract Spontaneous abortion (SA) is the spontaneous loss of a pregnancy before 20 gestational weeks. The causes of SA are still largely unknown. Long noncoding RNA (lncRNA) urothelial cancer associated 1 (UCA1) plays an important role in cellular progress. However, there is no report focusing on the role of UCA1 in SA. Here, we revealed that, compared with that in clinical samples from elective induced abortion, UCA1 expression was decreased in samples from SA patients as shown by qPCR method. The results demonstrated that UCA1 might be involved in the progress of SA. Then, we found that knockdown of UCA1 reduced cell viability and inhibited cell proliferation and migration of HTR-8/SVneo trophoblast cells as shown by CCK8, EdU, and Transwell methods. Furthermore, we demonstrated that UCA1 could act as a molecular sponge for miR-455 in HTR-8/SVneo cells as shown by luciferase reporter system method. In addition, miR-455 inhibited cell viability, cell proliferation and migration via regulating RUNX2 in HTR-8/SVneo cells. Ultimately, we illustrated that UCA1 plays its role via absorbing miR-455, thus promoting RUNX2 expression in HTR-8/SVneo cells. Collectively, this study first revealed the role and mechanism of UCA1 in the growth and migration of HTR-8/SVneo cells, indicating its potential as a diagnostic biomarker and therapeutic target for SA.
30
Katayama, Susumu. "Computable Variants of AIXI which are More Powerful than AIXItl". Journal of Artificial General Intelligence 10, n.º 1 (1 de enero de 2019): 1–23. http://dx.doi.org/10.2478/jagi-2019-0001.
Texto completoResumen
Abstract This paper presents Unlimited Computable AI, or UCAI, that is a family of computable variants of AIXI. UCAI is more powerful than AIXItl, which is a conventional family of computable variants of AIXI, in the following ways: 1) UCAI supports models of terminating computation, including typed lambda calculi, while AIXItl only supports Turing machine with timeout ˜t, which can be simulated by typed lambda calculi for any ˜t; 2) unlike UCAI, AIXItl limits the program length to some ˜l .
31
Deng, Li, Xiao Cheng Zhou, Deng Wu Ma y Hong Jun Zhai. "Research on UCAV Communication Data Link Capability Increasing Scheme". Advanced Materials Research 605-607 (diciembre de 2012): 1976–79. http://dx.doi.org/10.4028/www.scientific.net/amr.605-607.1976.
Texto completoResumen
UCAV data link capability is introduced on the paper. The special battle demand of UCAV data link is analyzed. Several schemes are put forward based on TCP to UCAV battle communication problem. They are compared on the paper and show the results. At last, the results are analyzed.
32
Patel, Supriya S., Amanda K. Arrington, Shaun McKenzie, Brian Mailey, Michelle Ding, Wendy Lee, Avo Artinyan, Nicholas Nissen, Steven D. Colquhoun y Joseph Kim. "Milan Criteria and UCSF Criteria: A Preliminary Comparative Study of Liver Transplantation Outcomes in the United States". International Journal of Hepatology 2012 (2012): 1–7. http://dx.doi.org/10.1155/2012/253517.
Texto completoResumen
The application of orthotopic liver transplantation (OLT) for patients with hepatocellular cancer (HCC) necessitates highly selective criteria to maximize survival and to optimize allocation of a scarce resource. The objective of this study was to compare the outcomes of OLT for HCC in patients transplanted under Milan and UCSF criteria. The United Network of Organ Sharing (UNOS) database was queried for patients who had undergone OLT for HCC from 2002 to 2007, and 1,972 patients (Milan criteria,n=1,913; UCSF criteria,n=59) were identified. Patients were stratified by pretransplant criteria (Milan versus UCSF), and clinical and pathologic factors and overall survival were compared. There were no differences in age, gender, diabetes mellitus, body mass index, and hepatitis B, or C status between the two groups. Overall survival was similar between the Milan and UCSF cohorts (1-, 2-, 3-, and 4-year survival rates: 88%, 81%, 76%, and 72% versus 91%, 80%, 68% and 51%, respectively,P=0.21). Although the number of patients within UCSF criteria was small, our results nevertheless suggest that patients with HCC may have equivalent survival when transplanted under Milan and UCSF criteria. Long-term followup may better determine whether UCSF criteria should be widely adopted.
33
Liu, Youbin, Daliang Zhou, Guangnan Li, Xing Ming, Ying feng Tu, Jinwei Tian, Huimin Lu y Bo Yu. "Long Non Coding RNA-UCA1 Contributes to Cardiomyocyte Apoptosis by Suppression of p27 Expression". Cellular Physiology and Biochemistry 35, n.º 5 (2015): 1986–98. http://dx.doi.org/10.1159/000374006.
Texto completoResumen
Background/Aims: Urothelial carcinoma-associated 1 (UCA1) is a recently identified long non coding RNA (lncRNA). However, few studies have explored its role in cardiomyocytes after focal cardiac ischemia reperfusion injury (CIR). Methods: Rat CIR models were established using ligation of the Lower Anterior Descending artery (LAD). Cell apoptosis and reactive oxygen species (ROS) production in cardiac tissues were explored using immunohistochemistry and DHE staining. lncRNA expression patterns were detected using microarray and validated by qPCR. Cell viability and apoptosis were examined using MTT assay and flow cytometry. Results: CIR significantly induced cell apoptosis and ROS production in the rat model. The results of microarray demonstrated the reduced expression of UCA1, which was validated by qPCR. Follow-up experiments showed that UCA1 was involved in H2O2-induced cell apoptosis. We further showed that UCA1 negatively correlated with the expression of p27. Moreover, overexpression of p27 could induce primary cardiomyocyte apoptosis. Conclusions: Reduction of UCA1 levels plays a pro-apoptotic role in primary cardiomyocytes partially through stimulation of p27 protein expression. These results are in agreement with the observed levels of UCA1, p27 and apoptosis after cardiac I/R injury, suggesting that UCA1 might have an important role during I/R injury.
34
Lanterna, Luigi A., Giovanni Tredici, Borislav D. Dimitrov y Francesco Biroli. "Treatment of Unruptured Cerebral Aneurysms by Embolization with Guglielmi Detachable Coils: Case-fatality, Morbidity, and Effectiveness in Preventing Bleeding—A Systematic Review of the Literature". Neurosurgery 55, n.º 4 (1 de octubre de 2004): 767–78. http://dx.doi.org/10.1227/01.neu.0000137653.93173.1c.
Texto completoResumen
Abstract OBJECTIVE: Guglielmi detachable coils (GDCs) increasingly are being used to treat unruptured cerebral aneurysms (UCAs). We systematically reviewed the literature to assess the case-fatality and permanent morbidity rates of GDC embolization of UCAs and the postembolization bleeding rate. METHODS: Through a MEDLINE search of the English, Italian, and French literature from January 1990 through December 2002, we retrieved studies on GDC embolization of aneurysms and extracted data on UCAs. Inclusion criteria were: 1) attempted GDC embolization of at least five consecutive patients with UCAs, 2) reported percentage of at least either case-fatality or permanent morbidity rate or crude data allowing an independent calculation. When data on UCAs could not be characterized with certainty among data on other, different lesions, the study was rejected. RESULTS: We included 30 studies. One thousand three hundred seventy-nine patients were available for the calculation of the case-fatality rate, 794 for the permanent morbidity rate, and 703 for the bleeding rate. The case-fatality rate was 0.6% (95% confidence interval, 0.2–1%), the permanent morbidity rate was 7% (95% confidence interval, 5.3–8.7%), and the bleeding rate was 0.9% per year (95% confidence interval, 0.41–1.4%). Only incompletely coiled UCAs of 10 mm or more accounted for the bleeding events. Morbidity decreased from 8.6% to 4.5% (P < 0.05) when the midyear of study (average calendar year of treatment) was 1995 or later. CONCLUSION: GDC embolization of UCAs is relatively safe, and the outcome is progressively improving. Partial embolization of UCAs of 10 mm or more is unlikely to provide an acceptable protection. Most of the source publications suffer from methodological weaknesses. Prospective studies with longer follow-up periods are needed to definitively assess the effectiveness of GDCs on UCAs.
35
Caci, Emanuela, Chiara Folli, Olga Zegarra-Moran, Tonghui Ma, Mark F. Springsteel, Robert E. Sammelson, Michael H. Nantz, Mark J. Kurth, A. S. Verkman y Luis J. V. Galietta. "CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds". American Journal of Physiology-Lung Cellular and Molecular Physiology 285, n.º 1 (julio de 2003): L180—L188. http://dx.doi.org/10.1152/ajplung.00351.2002.
Texto completoResumen
Activators of the CFTR Cl- channel may be useful for therapy of cystic fibrosis. Short-circuit current ( Isc) measurements were done on human bronchial epithelial cells to characterize the best flavone and benzimidazolone CFTR activators identified by lead-based combinatorial synthesis and high-throughput screening. The 7,8-benzoflavone UCcf-029 was a potent activator of Cl- transport, with activating potency (<1 μM) being much better than other flavones, such as apigenin. The benzimidazolone UCcf-853 gave similar Isc but with lower potency (5–20 μM). In combination, the effect induced by maximal UCcf-029 and UCcf-029, UCcf-853, and apigenin increased strongly with increasing basal CFTR activity: for example, Kd for activation by UCcf-029 decreased from >5 to <0.4 μM with increasing basal Isc from ∼4 μA/cm2 to ∼12 μA/cm2. This dependence was confirmed in permeabilized Fischer rat thyroid cells stably expressing CFTR. Our results demonstrate efficacy of novel CFTR activators in bronchial epithelia and provide evidence that activating potency depends on basal CFTR activity.
36
Liu, Pei, Lei Zhu, Fan Zhang, Junhao Lin, Min Du, Zilong Cao, Ling Ma y Zhensheng Hu. "LncRNA UCA1/miR-143 miR-216b/HK2/MAPK signaling pathway is involved in the regulation of endothelial cell proliferation via the modulation of glycolysis in melanoma". European Journal of Inflammation 17 (enero de 2019): 205873921983705. http://dx.doi.org/10.1177/2058739219837050.
Texto completoResumen
Long noncoding RNAs (lncRNAs) and microRNAs (miRNAs/miRs) are noncoding RNAs that function as regulators of tumor suppressors and oncogenes. The aim of the present study was to investigate the potential mechanism associated with the involvement of urothelial cancer associated 1 (UCA1) in melanoma. Reverse transcription-quantitative polymerase chain reaction and western blot analysis were performed in order to determine the expression levels of UCA1, miR-143, miR-216b, and hexokinase 2 (HK2) in the melanoma and control groups, as well as the influence of UCA1, miR-143, and miR-216b on the expression of HK2, and the effect of lactate and UCA1 on the phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK). Bioinformatics algorithm analysis and a luciferase assay were performed in order to predict miRNA targets. In addition, an MTT assay was performed in order to determine the effect of lactate and UCA1 expression on cell proliferation. A total of 39 participants, consisting of 18 patients with melanoma and 21 healthy control subjects, were included in the present study. The present study demonstrated that the expression levels of UCA1 mRNA, and HK2 mRNA and protein were enhanced in patients with melanoma compared with healthy controls; whereas the expression levels of miR-143 and miR-216b mRNA were suppressed in patients with melanoma compared with healthy controls. Furthermore, it was revealed that UCA1 negatively modulated the expression of miR-143 and miR-216b, and that miR-143 and miR-216b directly targeted the HK2 protein by binding to the HK2 3′ untranslated region (UTR). In addition, it was demonstrated that miR-143 and miR-216 suppressed the luciferase activity exhibited by wild-type HK2 3′-UTR. Furthermore, it was revealed that transfection with UCA1 small interfering RNA, and miR-143 and miR-216b mimics markedly suppressed HK2 mRNA and protein expression levels as well as lactate levels in human umbilical vein endothelial cells; however, O2 consumption was revealed to be enhanced post transfection. By contrast, transfection with UCA1 enhanced HK2 mRNA and protein expression levels as well as lactate production; however, O2 consumption was revealed to be suppressed post transfection. Lactate-induced phosphorylation of p38 MAPK was revealed to occur in a concentration-dependent manner, and UCA1 enhanced the phosphorylation level of p38 MAPK via the inhibition of miR-143 and miR-216b expression. Lactate and UCA1 were demonstrated to enhance cell proliferation. In conclusion, the present study demonstrated that the lncRNA UCA1/miR-143 miR-216b/HK2/lactic acid/MAPK axis may be involved in the pathogenesis of melanoma via the modulation of endothelial cells, and thus, lncRNA UCA1 may serve as a potential therapeutic target for melanoma treatment.
37
Avgeris, Margaritis, Anastasia Tsilimantou, Panagiotis K. Levis, Theodoros Rampias, Maria-Alexandra Papadimitriou, Konstantina Panoutsopoulou, Konstantinos Stravodimos y Andreas Scorilas. "Unraveling UCA1 lncRNA prognostic utility in urothelial bladder cancer". Carcinogenesis 40, n.º 8 (27 de febrero de 2019): 965–74. http://dx.doi.org/10.1093/carcin/bgz045.
Texto completoResumen
AbstractIn the era of precision oncology, bladder cancer (BlCa) is characterized by generic patient management and lack of personalized prognosis and surveillance. Herein, we have studied the clinical significance of urothelial cancer associated 1 (UCA1) lncRNA in improving patients’ risk stratification and prognosis. A screening cohort of 176 BlCa patients was used for UCA1 quantification. The Hedegaard et al. (n = 476) and The Cancer Genome Atlas (TCGA) provisional (n = 413) were analyzed as validation cohorts for non-muscle-invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC), respectively. Patients’ survival outcome was assessed using recurrence and progression for NMIBC or death for MIBC as clinical endpoint events. Bootstrap analysis was performed for internal validation of Cox regression analysis, whereas the clinical benefit of disease prognosis was assessed by decision curve analysis. UCA1 was significantly overexpressed in bladder tumors compared with normal urothelium, which was confirmed only in the case of NMIBC. Interestingly, reduced expression of UCA1 was correlated with muscle-invasive disease as well as with tumors of higher stage and grade. UCA1 loss was strongly associated with higher risk of short-term relapse [hazard ratio (HR) = 1.974; P = 0.032] and progression to invasive stages (HR = 3.476; P = 0.023) in NMIBC. In this regard, Hedegaard et al. and TCGA validation cohorts confirmed the unfavorable prognostic nature of UCA1 loss in BlCa. Finally, prognosis prediction models integrating UCA1 underexpression and established clinical disease markers contributed to improved stratification specificity and superior clinical benefit for NMIBC prognosis. Underexpression of UCA1 correlates with worse disease outcome in NMIBC and contributes to superior prediction of disease early relapse and progression as well as improved patient stratification specificity.
38
Li, Dagang, Huizong Li, Yuping Yang y Le Kang. "Long Noncoding RNA Urothelial Carcinoma-Associated 1 Promotes the Proliferation and Metastasis of Human Lung Tumor Cells by Regulating MicroRNA-144". Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 26, n.º 4 (7 de mayo de 2018): 537–46. http://dx.doi.org/10.3727/096504017x15009792179602.
Texto completoResumen
Long noncoding RNA urothelial carcinoma-associated 1 (lncRNA UCA1) has gained more attention in recent years due to its oncogenic roles in various cancers. MicroRNA-144 (miR-144) participates in the regulation of the growth of many cancer cells. This study investigated the interaction between lncRNA UCA1 and miR-144 in lung cancer cells. The potential downstream protein of miR-144 was also assessed. Our results found that lncRNA UCA1 was highly expressed in human lung cancer A549, H517, H4006, H1299, and H1650 cells compared to normal embryonic lung WI-38 and HEL-1 cells. Knockdown of lncRNA UCA1 significantly inhibited lung cancer A549 cell viability, migration, invasion, and cell cycle progression, but promoted cell apoptosis. Besides, we found that lncRNA UCA1 was bound to miR-144. miR-144 participated in the regulation effects of lncRNA UCA1 on A549 cell viability, migration, invasion, cell cycle transition, and cell apoptosis. In addition, Pre-B-cell leukemia homeobox 3 (PBX3) was found to be a direct target gene of miR-144. Overexpression of PBX3 promoted A549 cell proliferation and metastasis. Suppression of PBX3 had an opposite effect.
39
Zhu, Haoran, Yunhe Wang, Zhiqiang Ma y Xiangtao Li. "A Comparative Study of Swarm Intelligence Algorithms for UCAV Path-Planning Problems". Mathematics 9, n.º 2 (15 de enero de 2021): 171. http://dx.doi.org/10.3390/math9020171.
Texto completoResumen
Path-planning for uninhabited combat air vehicles (UCAV) is a typically complicated global optimization problem. It seeks a superior flight path in a complex battlefield environment, taking into various constraints. Many swarm intelligence (SI) algorithms have recently gained remarkable attention due to their capability to address complex optimization problems. However, different SI algorithms present various performances for UCAV path-planning since each algorithm has its own strengths and weaknesses. Therefore, this study provides an overview of different SI algorithms for UCAV path-planning research. In the experiment, twelve algorithms that published in major journals and conference proceedings are surveyed and then applied to UCAV path-planning. Moreover, to demonstrate the performance of different algorithms in further, we design different scales of problem cases for those comparative algorithms. The experimental results show that UCAV can find the safe path to avoid the threats efficiently based on most SI algorithms. In particular, the Spider Monkey Optimization is more effective and robust than other algorithms in handling the UCAV path-planning problem. The analysis from different perspectives contributes to highlight trends and open issues in the field of UCAVs.
40
Nugroho, B., J. Brett, B. T. Bleckly y R. C. Chin. "Numerical study of geometric morphing wings of the 1303 UCAV". Aeronautical Journal 125, n.º 1289 (22 de marzo de 2021): 1192–208. http://dx.doi.org/10.1017/aer.2021.15.
Texto completoResumen
ABSTRACTUnmanned Combat Aerial Vehicles (UCAVs) are believed by many to be the future of aerial strike/reconnaissance capability. This belief led to the design of the UCAV 1303 by Boeing Phantom Works and the US Airforce Lab in the late 1990s. Because UCAV 1303 is expected to take on a wide range of mission roles that are risky for human pilots, it needs to be highly adaptable. Geometric morphing can provide such adaptability and allow the UCAV 1303 to optimise its physical feature mid-flight to increase the lift-to-drag ratio, manoeuvrability, cruise distance, flight control, etc. This capability is extremely beneficial since it will enable the UCAV to reconcile conflicting mission requirements (e.g. loiter and dash within the same mission). In this study, we conduct several modifications to the wing geometry of UCAV 1303 via Computational Fluid Dynamics (CFD) to analyse its aerodynamic characteristics produced by a range of different wing geometric morphs. Here we look into two specific geometric morphing wings: linear twists on one of the wings and linear twists at both wings (wash-in and washout). A baseline CFD of the UCAV 1303 without any wing morphing is validated against published wind tunnel data, before proceeding to simulate morphing wing configurations. The results show that geometric morphing wing influences the UCAV-1303 aerodynamic characteristics significantly, improving the coefficient of lift and drag, pitching moment and rolling moment.
41
Xossain, Minaxay. "AN IT REVOLUTION: ARE UCAVS THE FUTURE OF AIR COMBAT?" Innovation in the economy 1, n.º 1 (10 de enero de 2019): 11–18. http://dx.doi.org/10.26739/2181-9491-2019-1-2.
Texto completo
42
Gürel, S. y M. Kiyici. "Ulcerative Colitis Activity Index: A Useful Prognostic Factor for Predicting Ulcerative Colitis Outcome". Journal of International Medical Research 33, n.º 1 (febrero de 2005): 103–10. http://dx.doi.org/10.1177/147323000503300111.
Texto completoResumen
We evaluated the usefulness of various parameters in predicting the prognosis of ulcerative colitis. The records of 73 patients with ulcerative colitis were examined retrospectively. Patients were divided into two groups according to whether they had received only 5-aminosalicylic acid (5-ASA; n = 26) or glucocorticoids and/or azathioprine with or without 5-ASA ( n = 47). The disease extent, endoscopic activity and ulcerative colitis activity index (UCAI) before therapy were recorded, together with the disease outcome. No statistically significant differences in outcome were observed in relation to therapy group, disease extent or endoscopic activity. UCAI had a significant effect on outcome, however: patients with lower UCAI values were more likely to remain in remission and less likely to require urgent surgery or experience a fatal outcome than those with higher UCAI values. This difference was apparent in both treatment groups. Thus a high pre-treatment UCAI may indicate a worse outcome.
43
Barinaga, Marcia. "UCSF space problem". Nature 327, n.º 6118 (mayo de 1987): 91. http://dx.doi.org/10.1038/327091b0.
Texto completo
44
Wallerstein, R. "Psychiatry at UCSF". Science 263, n.º 5149 (18 de febrero de 1994): 901. http://dx.doi.org/10.1126/science.8310283.
Texto completo
45
Weiner, H. "Psychiatry at UCSF". Science 263, n.º 5149 (18 de febrero de 1994): 901. http://dx.doi.org/10.1126/science.8310284.
Texto completo
46
Buchan, James. "Decoding UCAS figures". Nursing Standard 32, n.º 23 (31 de enero de 2018): 30. http://dx.doi.org/10.7748/ns.32.23.30.s20.
Texto completo
47
Sun, Xiao-Dong, Chen Huan, Wei Qiu, Da-Wei Sun, Xiao-Ju Shi, Chuan-Lei Wang, Chao Jiang, Guang-Yi Wang y Guo-Yue Lv. "Clinical Significance of UCA1 to Predict Metastasis and Poor Prognosis of Digestive System Malignancies: A Meta-Analysis". Gastroenterology Research and Practice 2016 (2016): 1–11. http://dx.doi.org/10.1155/2016/3729830.
Texto completoResumen
Purpose. Urothelial carcinoma-associated 1 (UCA1) has been reported to be overexpressed and correlated with progression in various cancers. However, the association between UCA1 expression and some clinicopathological features of digestive system malignancies, such as metastasis and survival, remains inconclusive. Therefore, a meta-analysis was performed to investigate the clinical significance of UCA1 in digestive system malignancies.Methods. Relevant literatures were searched in PubMed, Web of Science, Cochrane Library, and Embase databases updated to May 2016.Results. A total of 1089 patients from 10 studies were included in this meta-analysis. Meta-analysis results showed that digestive system malignancy patients with UCA1 overexpression were significantly more susceptible to developing lymph node metastasis (LNM) (OR = 1.85, 95% CI: 1.28–2.67) and distant metastasis (DM) (OR = 3.14, 95% CI: 1.77–5.58) and suffer from poor overall survival (OS) (HR = 2.31, 95% CI: 1.89–2.82, univariate analysis; HR = 2.24, 95% CI: 1.69–2.98, multivariate analysis) and poor disease-free survival (DFS) (HR = 2.65, 95% CI: 1.59–4.43, univariate analysis; HR = 2.50, 95% CI: 1.62–3.86, multivariate analysis).Conclusion. UCA1 overexpression was correlated with LNM, DM, poor OS, and poor DFS. UCA1 may serve as an indicator for metastasis and poor prognosis in digestive system malignancies.
48
Wang, Gaige, Lihong Guo, Hong Duan, Heqi Wang, Luo Liu y Mingzhen Shao. "A Hybrid Metaheuristic DE/CS Algorithm for UCAV Three-Dimension Path Planning". Scientific World Journal 2012 (2012): 1–11. http://dx.doi.org/10.1100/2012/583973.
Texto completoResumen
Three-dimension path planning for uninhabited combat air vehicle (UCAV) is a complicated high-dimension optimization problem, which primarily centralizes on optimizing the flight route considering the different kinds of constrains under complicated battle field environments. A new hybrid metaheuristic differential evolution (DE) and cuckoo search (CS) algorithm is proposed to solve the UCAV three-dimension path planning problem. DE is applied to optimize the process of selecting cuckoos of the improved CS model during the process of cuckoo updating in nest. The cuckoos can act as an agent in searching the optimal UCAV path. And then, the UCAV can find the safe path by connecting the chosen nodes of the coordinates while avoiding the threat areas and costing minimum fuel. This new approach can accelerate the global convergence speed while preserving the strong robustness of the basic CS. The realization procedure for this hybrid metaheuristic approach DE/CS is also presented. In order to make the optimized UCAV path more feasible, the B-Spline curve is adopted for smoothing the path. To prove the performance of this proposed hybrid metaheuristic method, it is compared with basic CS algorithm. The experiment shows that the proposed approach is more effective and feasible in UCAV three-dimension path planning than the basic CS model.
49
Rizal, Muhamad, Dewi Febriyanti, Husna `. Sabila, Wahyu Damarwati y Hanum Isfaeni. "Struktur Komunitas Uca Spp. Di Kawasan Hutan Mangrove, Bedul Utara, Taman Nasional Alas Purwo, Jawa Timur". PARAMETER: Jurnal Pendidikan Universitas Negeri Jakarta 29, n.º 1 (15 de mayo de 2017): 30–38. http://dx.doi.org/10.21009/parameter.291.04.
Texto completoResumen
Abstract
The study aims were to determine the community structure of Uca sp.and its environmental factor at the segara anakan north Bedul Alas purwo national park. Research conducted when the lowest tide began on april 24th,2017. At research station, 30 sampling points was determined by purposive sampling method. Samples ware taken by making 1x1 square, space 5m between each square and observed with the space 2m between square and observer and after ten minutes then recorded all the species belonging to each plot. Environment parameters measured to determine the diference of environmental factor to structure community of Uca crabs. Samples of crab preserved with formaldehida 4% and collected in tha jar. Eight species were found in segara anakan north bedul is Uca rosea, Uca perplexa, Uca capricornis, Uca bellator, Uca tetragonon, Uca crassipes, Uca rapax, Uca lactea.
Abstrak
Penelitian ini bertujuan untuk mengetahui struktur komunitas dari Uca sp. di kawasan hutan mangrove serta faktor lingkungan yang mempengaruhinya. Penelitian dilakukan pada saat air surut terendah. Penelitian ini dilakukan pada 24 April 2017. Metode yang dilakukan ialah dengan purposive sampling dan dengan menggunakan belt transek. Penelitian dilakukan dengan membuat plot berukuran 2 m x 2 m sebanyak 30 plot dan dengan jarak antar plot ialah 5 m. Penelitian dilakukan dengan pengamatan dari jarak 2 m dan setelah 10 menit kemudian di catat semua spesies yang termasuk ke dalam tiap plot. Dilakukan pengukuran parameter lingkungan untuk mengetahui perbedaan faktor lingkungan terhadap struktur komunitas kepiting Uca. Spesies kepiting yang telah tercatat diambil individunya untuk dijadikan sampel dan dilakukan identifikasi kemudian diawetkan di dalam botol selai dengan menggunakan formalin 4%. Sebanyak 8 jenis kepiting Uca yang ditemukan di hutan mangrove kawasan Bedul, yaitu Uca rosea, Uca perplexa, Uca capricornis, Uca bellator, Uca tetragonon, Uca crassipes, Uca rapax, Uca lactea.
50
Podzolkov, V. I., T. A. Safronova y D. U. Natkina. "Endothelial dysfunction in patients with controlled and uncontrolled arterial hypertension". Terapevticheskii arkhiv 91, n.º 9 (15 de septiembre de 2019): 108–14. http://dx.doi.org/10.26442/00403660.2019.09.000344.
Texto completoResumen
Aim. To conduct a comparative analysis of the level of asymmetric dimethylarginine (ADMA) in two groups of patients with a diagnosis of essential arterial hypertension (AH). Group I - patients with uncontrolled hypertension (UCAH) and group II - patients with controlled course of hypertension (CAH). Materials and methods. The study included 109 patients: group I - 73 patients with UCAH, group II - 36 patients with CAH. Groups were comparable. Clinical, laboratory and instrumental examination was performed, including determination of ADMA concentration in blood plasma. Results. The concentration of ADMA in patients with UCAH was significantly higher than in the group with CAH. In patients with UCAH, a pronounced positive correlation was found between the concentration of ADMA and creatinine level (r=0.615, p