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Literatura académica sobre el tema "Uveal Neoplasms – pathology"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 17 de junio de 2025

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Artículos de revistas sobre el tema "Uveal Neoplasms – pathology"

Cajaiba, Mariana M., Martha M. Chojniak, and Isabela W. Cunha. "Unusual Primary Ocular Neoplasm in a Child: Leiomyosarcoma of the Ciliary Body." Pediatric and Developmental Pathology 11, no. 6 (2008): 479–81. http://dx.doi.org/10.2350/07-02-0231.1.

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Primary uveal-tract neoplasms are extremely rare in childhood; the most common lesions found are melanocytic. We report here the case of a 7-year-old girl who underwent enucleation of the right eye with clinical suspicion of choroid melanoma as a result of a ciliary body mass that extended to the posterior chamber. Histologically, the neoplasm featured spindle cell morphology, atypia, and mitoses. The tumor expressed smooth muscle α actin, pan-actin HHF-35, and desmin, whereas immunohistochemistry for melanocytic markers, such as S-100, Melan-A, and HMB-45, was negative. Based on these features, the diagnosis of leiomyosarcoma of the ciliary body was firmly established. Although several leiomyomas have been reported in the literature, there are only 2 previously reported cases of primary leiomyosarcoma of the uveal tract. Immunohistochemical expression of muscle proteins allowed distinction from the most common melanocytic tumors arising in this location.

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Petrovic, Aleksandra, Ciara Bergin, Ann Schalenbourg, Gudrun Goitein, and Leonidas Zografos. "Proton therapy for uveal melanoma in 43 juvenile patients: long-term results." Ophthalmology 121, no. 4 (2014): 898–904. https://doi.org/10.1016/j.ophtha.2013.10.032.

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PURPOSE: To examine the metastatic and survival rates, eye retention probability, and the visual outcomes of juvenile patients after proton beam radiotherapy (PBRT) for uveal melanoma (UM). DESIGN: Retrospective case-factor matched control study. PARTICIPANTS AND CONTROLS: Forty-three patients younger than 21 years treated with PBRT for UM were compared with 129 matched adult control patients. METHODS: Information on patient demographics and clinical characteristics were recorded before and after treatment from patients' files. The control group was composed of adult patients (>21 years) matched for tumor size (largest tumor diameter, ±2 mm; height, ±2 mm) and anterior margin location (iris, ciliary body, pre-equatorial or postequatorial choroid). For each juvenile patient, 3 adults were selected. MAIN OUTCOME MEASURES: Comparing outcomes of juvenile and adult patients in terms of metastatic and eye retention rates using the log-rank statistic, relative survival using the Hakulinen method, as well as their visual outcomes. RESULTS: Forty-three juvenile and 129 control cases were reviewed. The metastatic rate at 10 years was significantly lower in juvenile UM patients than in adult controls (11% vs. 34%; P <0.01), with an associated relative survival rate of 93% versus 65% (P = 0.02). Six juvenile patients (14%) demonstrated metastases. One patient underwent enucleation because of a presumed local tumor recurrence and 4 additional patients underwent enucleation because of complications (9.3%). In the adult control group, 27% (n = 35) of matched patients demonstrated metastases, there were 2 cases of local recurrence, and 16% (n = 21) underwent enucleation because of complications. A visual acuity of more than 0.10 was maintained in most cases, without any significant differences before or after treatment observed between both groups. CONCLUSIONS: After PBRT, metastatic and survival rates are significantly better for juvenile than for adult patients with UM. Clinically, juvenile and adult eyes react similarly to PBRT, with patients having a comparable eye retention probability and maintaining a useful level of vision in most cases. This is the largest case-control study of proton therapy in juvenile eyes to date and further validates PBRT as an appropriate conservative treatment for UM in patients younger than 21 years.

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Mykhailenko, N. I., та D. V. Voitsekhovych. "Морфологічні особливості новоутворень ока у собак". Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 19, № 82 (2017): 41–44. http://dx.doi.org/10.15421/nvlvet8209.

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Tumors of the eyes in pets are relatively rare. Tumors can adversely affect the functions of the eye, lead to damage to its structures, discoloration, discomfort or changes in the shape of the eyeball. The study of the morphological features of neoplasms of the eye has not only scientific or general biological interest, but also has a purely practical significance.The purpose of our work was to study the frequency of diagnosis, morphological, clinical and macroscopic features of various histological types of eye neoplasms. It was analyzed 178 cases of tumors of different localization in dogs that were admitted to the Department of Pathological Anatomy of the NUP of Ukraine for histological examination from various clinics of veterinary medicine in Kyiv. Neoplasms of the eye were about 3%. The ratio between malignant and benign neoplasms was 1:1. The average age of the sick dogs was 7 years. Most often the eyelids and other parts of the eye's auxiliary apparatus were affected. In only one case, an intraocular tumor was noted. Such statistics are not accurate, as most owners refuse surgical removal of the eyeball. The prevailing clinical form of neoplasm was nodular. Macroscopically, most tumors had a regular oval shape. In one case, an ulcer was found on the surface of the tumor. The melanoma of the uveal tract, the squamous cell carcinoma of the eyelid, the eccrine acrospiroma of the sweat glands of the eyelids, the adenocarcinoma of the sebaceous glands of the eyelids, the hemangioma of the orbit and neurofibroma were diagnosed. Histologically, the neoplasms of the eye did not differ from other similar localizations.The obtained data will supplement the knowledge of researchers of other countries about the histological structure of tumors that are recorded in the eye area, as well as the role of the geographical factor, environmental conditions in the development of oncological pathology.

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Aprelev, A. E., Z. F. Abdulgazizova, I. I. Zakirova, and A. A. Aprelev. "Epidemiology of neoplasms of the eye and adnexa in Orenburg region." Russian Ophthalmological Journal 15, no. 3 (2022): 7–10. http://dx.doi.org/10.21516/2072-0076-2022-15-3-7-10.

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Purpose. To analyze the incidence of neoplasms of the eye and its appendages among residents of the Orenburg region, and determine its structure and dynamics within a 5-year period (2013 to 2017).Material and methods. A retrospective analysis of morbidity of patients of the polyclinic and the 2nd ophthalmological department of Orenburg Regional Clinical Hospital No. 1 was performed for the patients aged 4 months to 90 years.Results. Over the analyzed period (2013-2017) the incidence of oncological diseases of the eye and adnexa fell by 42 %. On the other hand, the share of malignant neoplasms increased by 40.3 %. On the whole, out-patients with neoplasms showed 68.6 % of basal cell carcinomas and 31.4 % of other malignancies, while hospitalized patients showed 58 % of basal cell carcinomas, 23.7 % of uveal melanomas and 18.3 % of other malignancies. Oncopathology of the eye and adnexa was found to affect women twice as often as men.Conclusion. The obtained results may be used to assess the changes of the morbidity for Orenburg region in prospective and retrospective aspects, as well as assess, by extrapolation, the incidence of the pathology under study in other Russian areas.

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Orcurto, Victoria, Alban Denys, Verena Voelter, et al. "(18)F-fluorodeoxyglucose positron emission tomography/computed tomography and magnetic resonance imaging in patients with liver metastases from uveal melanoma: results from a pilot study." Melanoma Research 22, no. 1 (2012): 63–69. https://doi.org/10.1097/CMR.0b013e32834d3dcb.

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PURPOSE: (18)F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) and MRI are used for detecting liver metastases from uveal melanoma. The introduction of new treatment options in clinical trials might benefit from early response assessment. Here, we determine the value of FDG-PET/CT with respect to MRI at diagnosis and its potential for monitoring therapy. MATERIAL AND METHODS: Ten patients with biopsy-proven liver metastases of uveal melanoma enrolled in a randomized phase III trial (NCT00110123) underwent both FDG-PET coupled with unenhanced CT and gadolinium-diethylene triamine pentaacetic acid-enhanced liver MRI within 4 weeks. FDG-PET and MRI were evaluated blindly and then compared using the ratio of lesion to normal liver parenchyma PET-derived standardized uptake value (SUV). The influence of lesion size and response to chemotherapy were studied. RESULTS: Overall, 108 liver lesions were seen: 34 (31%) on both modalities (1-18 lesions/patient), four (4%) by PET/CT only, and 70 (65%) by MRI only. SUV correlated with MRI lesion size (r=0.81, P<0.0001). PET/CT detected 26 of 33 (79%) MRI lesions of more than or equal to 1.2 cm, whereas it detected only eight of 71 (11%) lesions of less than 1.2 cm (P<0.0001). MRI lesions without PET correspondence were small (0.6±0.2 vs. 2.1±1.1 cm, P<0.0001). During follow-up (six patients, 30 lesions), the ratio lesion-to-normal-liver SUV diminished in size-stable lesions (1.90±0.64-1.46±0.50, P<0.0001), whereas it increased in enlarging lesions (1.56±0.40-1.99±0.56, P=0.032). CONCLUSION: MRI outweighs PET/CT for detecting small liver metastases. However, PET/CT detected at least one liver metastasis per patient and changes in FDG uptake not related to size change, suggesting a role in assessing early therapy response.

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Schoenfield, Lynn, James Pettay, Raymond R. Tubbs, and Arun D. Singh. "Variation of Monosomy 3 Status Within Uveal Melanoma." Archives of Pathology & Laboratory Medicine 133, no. 8 (2009): 1219–22. http://dx.doi.org/10.5858/133.8.1219.

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Abstract Context.—Determining the most significant prognostic variables in uveal melanoma is important for stratifying patients for metastasis surveillance and possible initiation of chemotherapy or immunotherapy. Monosomy 3, one such variable, can be determined using fluorescence in situ hybridization, either on enucleated samples, fine-needle aspiration biopsy, or tumor sample obtained by vitrector. Objective.—To evaluate possible regional discordance in chromosome 3 by sites likely to be sampled by different biopsy methods. Design.—Eighteen consecutive patients with uveal melanoma who underwent primary enucleation were studied. Representative paraffin blocks were selected based on review of hematoxylin-eosin stained sections, and the apex and base of each tumor was demarcated. Unstained paraffin sections, 4 μm in thickness, were prepared, and fluorescence in situ hybridization, looking for monosomy 3, was performed. The chromosomal analysis was also correlated with histologic evaluation for melanoma cell type (spindle vs epithelioid cell), ciliary body involvement, presence of positive periodic acid–Schiff vascular mimicry patterns, scleral or extrascleral spread and size. One case was excluded because of necrosis. Results.—Ten of the 17 remaining cases (59%) demonstrated monosomy 3 (in either the base or both base and apex of the tumor) with 7 cases (41%) showing disomy. Seven cases (70%) with monosomy 3 demonstrated this in both the apex and the base locations, whereas 3 cases (30%) showed monosomy in one location only (always at the base). Fourteen of the 17 cases (82%) revealed concordance in chromosome 3–monosomy 3 (7 of 14, 50%) or chromosome 3–disomy 3 (7 of 14, 50%). All 3 discordant cases demonstrated the monosomy 3 at the base with disomy at the apex. Lack of concordance between the base and apex did not correlate with melanoma cell type. Conclusions.—Prognostic variables are important in management of neoplasms, and this study points out that the site of tissue biopsy for prognostication in uveal melanoma could affect the results obtained, at least for the presence of monosomy 3.

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San-Miguel, Teresa, Lara Navarro, Beatriz Sánchez-Sendra, et al. "Identification of a Novel BRCA1 Alteration in Recurrent Melanocytoma Resulting in Increased Proliferation." Journal of Neuropathology & Experimental Neurology 79, no. 11 (2020): 1233–38. http://dx.doi.org/10.1093/jnen/nlaa089.

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Abstract Primary meningeal melanocytomas are rare tumors of the central nervous system. Although they are considered benign neoplasms, some reports describe recurrent rates up to 45%. Little is known about their genetic and epigenetic landscape because of their infrequency. Even less has been described about markers with prognostic value. Here we describe a patient who developed a primary meningeal melanocytoma, suffered 3 recurrences in a period of 6 years and died of the tumor. The genetic and epigenetic changes explored confirmed GNAQ mutation as an initiating event. We found an epigenetic alteration of GSTP1, a feature that has recently been described in meningiomas, from the beginning of the disease. In addition, there was loss of heterozygosity in BRCA1 beginning in the second recurrence that was linked to an increase in the proliferation index; this suggested a progression pathway similar to the one described in uveal melanomas. These findings underscore the necessity of further research focused on these tumors.

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Ciulla, Thomas A., Richard A. Bains, Frederick A. Jakobiec, Trexler M. Topping, and Evangelos S. Gragoudas. "Uveal lymphoid neoplasia: A clinical-pathologic correlation and review of the early form." Survey of Ophthalmology 41, no. 6 (1997): 467–76. http://dx.doi.org/10.1016/s0039-6257(97)00015-5.

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Foti, Pietro Valerio, Mario Travali, Renato Farina, et al. "Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part I: MR imaging with pathologic correlation and technical considerations." Insights into Imaging 12, no. 1 (2021). http://dx.doi.org/10.1186/s13244-021-01000-x.

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AbstractUveal melanoma is a malignant neoplasm that derives from pigmented melanocytes of the uvea and involves, in order of decreasing prevalence, the choroid, ciliary body and iris. Its prognosis is related to histopathologic and genetic features, tumor size and location, extraocular extension. The diagnosis is fundamentally based on clinical evaluation (ophthalmoscopy, biomicroscopy) and ultrasonography. MRI is useful in case of untransparent lens or subretinal effusion. Moreover, MRI has a significant role to confirm the diagnosis, in the evaluation of the local extent of the disease with implications for treatment planning, and in the follow-up after radiotherapy treatment. Uveal melanoma can show different morphologic features (lentiform, dome or mushroom shape) and often determines retinal detachment. MR appearance of uveal melanoma mainly depends on the melanin content. Uveal melanoma typically displays high signal intensity on T1-weighted images and low signal intensity on T2-weighted images. Nevertheless, imaging appearance may be variable based on the degree of pigmentation and the presence of areas of necrosis or cavitation. Differential diagnosis includes other uveal lesions. The radiologists and in particular MRI play a significant role in the clinical management of uveal melanoma. The purpose of this pictorial review is to provide the radiologists with awareness about diagnostic methods and therapeutic options of uveal melanoma. In the present first section we summarize the MR anatomy of the eye and describe ophthalmological and radiological imaging techniques to diagnose uveal melanomas, with emphasis on the role of MR imaging. Additionally, we review MR imaging appearance of uveal melanomas.

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Milman, Tatyana, Orlando G. Gonzalez Martinez, Martin Calotti, Roger K. Henry, and Ralph C. Eagle. "Consultations in Eye Pathology: Experience at the Ophthalmology Specialty Hospital." Archives of Pathology & Laboratory Medicine, June 22, 2023. http://dx.doi.org/10.5858/arpa.2022-0507-ra.

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Context.— Ophthalmic pathology is a discipline that relies heavily on a knowledge of clinical ophthalmology. The diagnosis of ocular and periocular lesions can be challenging because some lesions and diseases are unique to this region, whereas others may demonstrate site-specific differences from nonocular counterparts. Because of these challenges, ocular and periocular biopsies are frequently referred to specialized ophthalmic pathology centers for second opinion diagnoses. Objective.— To analyze the referral patterns, diagnostic challenges, and diagnostic discrepancies for second opinion referrals at a dedicated ophthalmic pathology laboratory with an emphasis on lesions of special interest in ophthalmic pathology. Data Sources.— Data sources included the pathology records of all slides and blocks received in consultation at the referral eye pathology center between December 1, 2015, and December 1, 2022, the personal experience of senior authors, and published peer-reviewed literature. Conclusions.— Corneal, intraocular, and conjunctival biopsies are the most common types of cases received in consultation without the referring pathologist's diagnosis, likely reflecting diagnostic challenges. Degenerative intraocular processes occasionally raise concern for a neoplasm. Conjunctival melanocytic lesions are the most common conjunctival biopsies referred for second opinion diagnosis and require careful tissue sampling and clinical-pathologic correlation. Careful clinical-pathologic correlation, a high level of suspicion, and adequate sampling also are required for the accurate diagnosis of periocular sebaceous carcinoma. The diagnostic discrepancies involving uveal, retinal, conjunctival, eyelid, and temporal artery biopsies are most likely to adversely influence patient management and possible outcome. Such specimens may benefit from referral to specialized ophthalmic pathology laboratories.

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Tesis sobre el tema "Uveal Neoplasms – pathology"

Logan, Patrick 1982. "In vivo imaging of liver metastasis using green fluorescent protein labelled human uveal melanoma cells in a mouse model." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112536.

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Uveal melanoma is the most common primary malignant intraocular tumour in adults and despite advances in treatment of the primary tumour, the 10-year survival rate remains unchanged. The most frequent cause of death for patients of this disease is liver metastases. Removal of the primary tumour before clinical presentation of metastases, however, has no effect on patient outcome.<br>In order to understand the interactions between single malignant cells or sub-clinical metastases and affected organs, we have successfully developed a novel animal model of uveal melanoma. We utilized the unique properties of green fluorescent protein, a skin-flap in vivo imaging technique, and nude mice to accomplish this goal. The precision of green fluorescent protein imaging has allowed us to observe single cells interacting with organ tissues and reveal that these malignant cells are only capable of surviving in the liver.

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Libros sobre el tema "Uveal Neoplasms – pathology"

M, Albert Daniel, and Polans Arthur, eds. Ocular oncology. Marcel Dekker, 2003.

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Font, Ramon L. Tumors of the eye and ocular adnexa. American Registry of Pathology in collaboration with the Armed Forces Institute of Pathology, 2006.

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McLean, Ian W., M.D., Armed Forces Institute of Pathology (U.S.), and Universities Associated for Research and Education in Pathology., eds. Tumors of the eye and ocular adnexa. Armed Forces Institute of Pathology, 1994.

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Ocular Oncology. Informa Healthcare, 2003.

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Albert, Daniel M., and Arthur Polans. Ocular Oncology. Taylor & Francis Group, 2003.

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Albert, Daniel M., and Arthur Polans. Ocular Oncology. Taylor & Francis Group, 2019.

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Capítulos de libros sobre el tema "Uveal Neoplasms – pathology"

Mendoza, Pia R., and Hans E. Grossniklaus. "Pathology of the Uveal Tract: Neoplasms." In Albert and Jakobiec's Principles and Practice of Ophthalmology. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-42634-7_131.

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