Bibliografías temáticas / Valproic acid therapeutic use

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Literatura académica sobre el tema "Valproic acid therapeutic use"

Autor: Grafiati
Publicado: 4 de junio de 2021
Última modificación: 26 de julio de 2025

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Artículos de revistas sobre el tema "Valproic acid therapeutic use"

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Bruserud, Øystein, Galina Tsykunova, Maria Hernandez-Valladares, Hakon Reikvam, and Tor Henrik Anderson Tvedt. "Therapeutic Use of Valproic Acid and All-Trans Retinoic Acid in Acute Myeloid Leukemia—Literature Review and Discussion of Possible Use in Relapse after Allogeneic Stem Cell Transplantation." Pharmaceuticals 14, no. 5 (2021): 423. http://dx.doi.org/10.3390/ph14050423.

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Even though allogeneic stem cell transplantation is the most intensive treatment for acute myeloid leukemia (AML), chemo-resistant leukemia relapse is still one of the most common causes of death for these patients, as is transplant-related mortality, i.e., graft versus host disease, infections, and organ damage. These relapse patients are not always candidates for additional intensive therapy or re-transplantation, and many of them have decreased quality of life and shortened expected survival. The efficiency of azacitidine for treatment of posttransplant AML relapse has been documented in se
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Gelbard, Amos. "Valproic Acid in Parkinson's Disease: A Friend or Foe?" British Journal of Healthcare & Medical Research 12, no. 03 (2025): 238–40. https://doi.org/10.14738/bjhr.1203.18873.

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There have been several reports of Parkinson's disease like symptoms being a side effect of Valproic Acid use. Valproic Acid is a drug prescribed for Epileptic seizures and also as a mood stabilizer. Despite the said reports of Parkinson's like side effects, several other studies had shown it to in fact be neuroprotective and perhaps therapeutic against PD in vivo. This review will center around these few studies, bring their results and ask for more experimentation to solve this issue of whether Valproic Acid triggers Parkinson's or perhaps triggers a healing from it. I would hypothesize in t
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Vázquez, Marta, Pietro Fagiolino, Cecilia Maldonado, et al. "Hyperammonemia Associated with Valproic Acid Concentrations." BioMed Research International 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/217269.

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Valproic acid, a branched short-chain fatty acid, has numerous action mechanisms which turn it into a broad spectrum anticonvulsant drug and make its use possible in some other pathologies such as bipolar disorder. It is extensively metabolized in liver, representingβ-oxidation in the mitochondria one of its main metabolic route (40%). Carnitine is responsible for its entry into the mitochondria as any other fatty acid. Long-term high-dose VPA therapy or acute VPA overdose induces carnitine depletion, resulting in high levels of ammonia in blood. As a high correlation between salivary valproic
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Sari, Dini Permata, and Winda Septyani Sianipar. "Pemantauan Kadar Obat Antiepilepsi dalam Darah terhadap Clinical Outcome pada Pasien Epilepsi di RSPAD Gatot Soebroto dengan Pendekatan Farmakokinetika." Pharmaceutical and Biomedical Sciences Journal (PBSJ) 6, no. 2 (2024): 124–35. https://doi.org/10.15408/pbsj.v6i2.38924.

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The use of antiepileptic drugs requires monitoring of blood drug levels because antiepileptics are drugs with a narrow therapeutic index. This study was conducted to determine the relationship between the accuracy of blood antiepileptic drug levels and clinical outcomes in epilepsy patients at RSPAD Gatot Soebroto using a pharmacokinetic approach. This study is an analytical observational study with a retrospective cross-sectional study of epilepsy patients using antiepileptic drugs from January 2023 to January 2024 at RSPAD Gatot Soebroto Jakarta. The results of this study showed that the mos
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Rasiani, Salma. "The impact of valproic acid administration: Effects on the growth of tongue cancer cells." Asian Journal of Toxicology, Environmental, and Occupational Health 2, no. 1 (2024): 13–26. http://dx.doi.org/10.61511/ajteoh.v2i1.2024.939.

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Background: Tongue cancer represents the predominant malignancy within the oral cavity (25-40% of squamous cell carcinoma), necessitating treatment modalities such as surgery, radiotherapy, and chemotherapy. Valproic acid, an antiepileptic medication, functions as a histone deacetylase inhibitor or activator of anti-tumor signaling pathways. Objective: To deepen our understanding of the effects of valproic acid on the viability, cytotoxicity, proliferation, and migration capabilities of HSC-3 cells. Method: This study employed an in vitro laboratory approach, exposing HSC-3 cells to valproic a
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Bidzan, Leszek. "USE OF VALPROIC ACID FOR THE TREATMENT OF NEUROPSYCHIATRIC SYMPTOMS IN ACQUIRED BRAIN INJURIES." Acta Neuropsychologica 18, no. 3 (2020): 357–66. http://dx.doi.org/10.5604/01.3001.0014.3876.

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Acquired brain injuries are often accompanied by a series of neuropsychiatric disorders. A wide range of pharmacological agents are used to treat neuropsychiatric symptoms. However, a more indepth review of the agents used indicates that there are in fact relatively few procedures recommended for use. Anticonvulsants including valproic acid, are of particular interest. This research aimed to assess the efficacy and safety of valproic acid, as based on a naturalistic observation of patients with various forms of acquired brain injury and who had displayed neuropsychiatric symptoms. The study gr
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Yee, Jennie L., David Wong, and Thomas M. Ormiston. "Encephalopathy and Hyperammonemia Associated with Valproic Acid." Journal of Pharmacy Technology 21, no. 6 (2005): 348–50. http://dx.doi.org/10.1177/875512250502100607.

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Objective: To discuss the case of a patient who experienced an altered level of consciousness secondary to hyperammonemia associated with valproic acid who had normal drug concentrations and liver function tests. Case Summary: A 48-year-old man with a history of seizure disorder treated with valproic acid presented with an altered level of consciousness. An extensive workup revealed only an increased ammonia level. His medications were withheld. Within 24 hours, the ammonia level returned to normal and he was able to be aroused. His antiseizure medication was changed to gabapentin. All of his
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Chateauvieux, Sébastien, Franck Morceau, Mario Dicato, and Marc Diederich. "Molecular and Therapeutic Potential and Toxicity of Valproic Acid." Journal of Biomedicine and Biotechnology 2010 (2010): 1–18. http://dx.doi.org/10.1155/2010/479364.

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Valproic acid (VPA), a branched short-chain fatty acid, is widely used as an antiepileptic drug and a mood stabilizer. Antiepileptic properties have been attributed to inhibition of Gamma Amino Butyrate (GABA) transaminobutyrate and of ion channels. VPA was recently classified among the Histone Deacetylase Inhibitors, acting directly at the level of gene transcription by inhibiting histone deacetylation and making transcription sites more accessible. VPA is a widely used drug, particularly for children suffering from epilepsy. Due to the increasing number of clinical trials involving VPA, and
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Memon, Madeeha, Chetan Das, Shazia, Ayesha Almas, Shahjan, and Touseef. "FREQUENCY OF VALPROIC INDUCED THROMBOCYTOPENIA AND SERUM VALPROIC ACID LEVEL IN EPILEPTIC PATIENTS PRESENTING AT CIVIL HOSPITAL (LUMHS), HYDERABAD." Insights-Journal of Health and Rehabilitation 3, no. 2 (Health & Rehab) (2025): 109–15. https://doi.org/10.71000/ha45ba86.

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Background: Valproic acid is a widely prescribed broad-spectrum antiepileptic drug used in the management of various seizure disorders. Despite its efficacy, its use is associated with multiple adverse effects, including thrombocytopenia, which can increase the risk of bleeding complications. The identification and monitoring of valproic acid-induced thrombocytopenia are essential to ensuring safe and effective treatment. However, limited local data exist on the prevalence of this adverse effect, necessitating further investigation to establish appropriate monitoring and management strategies
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Boonlue, Tuanthon, Papitchaya Sitsuer, Wasinee Phosri, and Warisara Jinatongthai. "Factors associated with subtherapeutic levels of valproic acid in hospitalized patients with epilepsy: A retrospective cohort study." Medicine 103, no. 45 (2024): e40488. http://dx.doi.org/10.1097/md.0000000000040488.

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Valproic acid (VPA) is a commonly used anti-seizure medication, owing to its efficacy and cost-effectiveness. However, maintaining appropriate serum levels is crucial due to the narrow therapeutic window, as subtherapeutic levels can lead to treatment failure or adverse outcomes. This study aimed to identify the factors associated with subtherapeutic serum levels of valproic acid in patients undergoing treatment. This retrospective cohort study was performed at a tertiary care hospital and involved inpatients aged ≥ 18 years who were receiving valproic acid for epilepsy treatment. Data were ob
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Tesis sobre el tema "Valproic acid therapeutic use"

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Conceição, Erika Christina Gouveia da. "Análise observacional de aquisições motoras em crianças portadoras de Amiotrofia Espinal Tipo I submetidas à intervenção medicamentosa com ácido valpróico." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-04082008-111025/.

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A amiotrofia espinal (AEP) é a mais freqüente das doenças neuromusculares (DNM) responsáveis pela Síndrome da Criança Hipotônica (SCH), causada pela degeneração das células do corno anterior da medula espinhal. O comprometimento neurológico se estabelece de forma rápida e intensa nos primeiros meses de vida de tal maneira que, em pouco tempo, a única atividade motora voluntária persistente pode ser a motricidade ocular. O Ácido Valpróico é um medicamento de fácil aquisição e administração, demonstrou-se eficaz em evitar a deleção do exon 7, o que prolongaria ainda mais a sobrevivência dos neur
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Pawlish, Gerald Joseph. "TAILORING DRUG-CARRIER INTERACTIONS IN POLY(SIALIC ACID) MICELLES FOR USE AS CANCER THERAPEUTIC CARRIERS." Diss., Temple University Libraries, 2018. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/519673.

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Bioengineering<br>Ph.D.<br>Although great progress has been made, cancer still remains one of the most prevalent maladies plaguing mankind. New treatment methodologies using nanoparticles have come to the forefront by allowing for enhanced delivery of therapeutics to the tumor site. The design of the nanoparticle should allow for long circulation times, tumor-specific targeting and efficient release at the site of action. This requires that both the external shell and internal core of the nanoparticle be carefully selected to meet the maximal criteria of each of these steps. Poly(sialic acid)
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Mohamad, Bustaman Ahmad Fahmi. "The effectiveness of intra-articular hyaluronic acid in temporomandibular disorders." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44661150.

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Liang, Wanling, and 梁婉玲. "Formulation of nucleic acid with pH-responsive amphipathic peptides for pulmonary delivery." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/207996.

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Jetson, Rachael Rene. "Design and Development of Potential Therapeutic Agents for Use in Hormone Responsive Cancers." University of Toledo Health Science Campus / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=mco1384270219.

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Potter, Kathleen. "The effects of long-term homocysteine-lowering treatment with folic acid, vitamin B6 and Vitamin B12 on vascular structure and function in stroke." University of Western Australia. School of Medicine and Pharmacology, 2009. http://theses.library.uwa.edu.au/adt-WU2010.0020.

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[Truncated abstract] An elevated total plasma homocysteine concentration (tHcy) is associated with an increased risk of myocardial infarction and ischemic stroke. Folic acid, vitamin B6 and B12 supplements significantly reduce tHcy even in people who are not overtly vitamin deficient. If homocysteine is a causal risk factor for atherothrombotic events, treatment with B-vitamins might prove a simple and cost-effective means to reduce cardiovascular risk. However, it remains unclear whether elevated tHcy causes atherosclerosis or is simply a risk marker. To prove that homocysteine is a modifiabl
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Xie, Lixia. "Effects of salvianolic acid B against apoptosis and adhesion molecules expression in the vascular endothelial cells." HKBU Institutional Repository, 2009. http://repository.hkbu.edu.hk/etd_ra/1082.

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Péraudeau, Elodie. "Évaluation et optimisation de l'efficacité de conjugués anticancéreux ciblant les récepteurs de l'acide folique." Thesis, Poitiers, 2016. http://www.theses.fr/2016POIT2309/document.

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En dépit des progrès réalisés ces dernières décennies, le cancer demeure un problème majeur de santé publique. La plupart des chimiothérapies conventionnelles exploitent les propriétés cytotoxiques d'agents non sélectifs qui affectent les cellules à division rapide, qu'elles soient cancéreuses ou non, ce qui peut aboutir à une toxicité importante et de sévères effets secondaires. Pour pallier à ce problème, l'utilisation de ligands de ciblage pour délivrer spécifiquement l'agent cytotoxique aux cellules malignes tout en épargnant les tissus sains est une approche prometteuse. Parmi les différe
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Müller, Adrienne Carmel. "An investigation into the neuroprotective properties of acyclovir." Thesis, Rhodes University, 2006. http://hdl.handle.net/10962/d1003254.

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Accumulating evidence suggests that quinolinic acid has a role to play in disorders involving impairment of learning and memory. In the present study, the effect of the guanosine analogue antiherpetic, acyclovir, on quinolinic acid-induced spatial memory deficits was investigated, as well as some of the mechanisms which underlie this effect. Behavioural studies using a Morris water maze show that post-treatment of rats with acyclovir significantly improves spatial memory deficits induced by intrahippocampal injections of quinolinic acid. Histological analysis of the hippocampi show that the ef
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Xu, Zheyang (Kevin). "Pomegranate flower ameliorates fatty liver in an animal model of type 2 diabetes and obesity : upregulation of hepatic expression of genes responsible for fatty acid oxidation." Thesis, The University of Sydney, 2008. https://hdl.handle.net/2123/28956.

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Pomegranate flower (PGF) has been prescribed in Unani and Ayurvedic medicines for the treatment of diabetes. It has been demonstrated that PGF extract activates peroxisome proliferator-activated receptor (PPAR) -or and -y to improve glucose tolerance, hyperlipidemia and excess cardiac triglyceride (TG) accumulation in Zucker diabetic fatty (ZDF) rats. Fatty liver (hepatic steatosis), the most common cause of abnormal liver function tests, is strongly associated with insulin resistance. The effect and its underlying mechanism of PGF on fatty liver was investigated in ZDF rats and in huma
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Libros sobre el tema "Valproic acid therapeutic use"

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K, Ghosh Arun. Aspartic acid proteases as therapeutic targets. Wiley-VCH, 2010.

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K, Ghosh Arun. Aspartic acid proteases as therapeutic targets. Wiley-VCH, 2010.

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Pedersen, Stephanie. Vitamin C: Building flexibility & fighting infection. Dorling Kindersley Pub., 2000.

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International Symposium on Orotic Acid and Magnesiumorotate (1991 Rüdesheim, Hesse, Germany). Orotic acid in cardiology. Georg Thieme Verlag ; New York : Thieme Medical Publishers, 1992.

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Jones, Janice E., and Danielle M. Morano. Tyrosine and aspartic acid: Properties, sources, and health benefits. Nova Science Publishers, 2011.

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Schrör, Karsten. Acetylsalicylic acid. Wiley-VCH, 2009.

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C, Teale M., ed. Omega 3 fatty acid research. Nova Science Publishers, 2005.

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Giancarlo, Folco, North Atlantic Treaty Organization. Scientific Affairs Division., and NATO Advanced Study Institute on Eicosanoids: From Biotechnology to Therapeutic Applications (1995 : Erice, Italy), eds. Eicosanoids: From biotechnology to therapeutic applications. Plenum Press, 1996.

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Klenner, Frederick R. Vitamin C as a fundamental medicine: Abstracts of Dr. Frederick R. Klenner, M.D.'s published and unpublished work. Life Sciences Press, 1988.

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Osada, Shōmatsu. Kuensan kenkōhō de 100-sai made ikiru. Metamoru Shuppan, 2002.

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Capítulos de libros sobre el tema "Valproic acid therapeutic use"

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Cotariu, D., S. Evans, J. L. Zaidman, and A. Yulzari. "Valproic Acid Enhances Lipid Peroxidation in Rat Liver, in Vivo." In Recent Developments in Therapeutic Drug Monitoring and Clinical Toxicology. CRC Press, 2023. http://dx.doi.org/10.1201/9781003418153-66.

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Novokhatny, Valery, James Rebbeor, Philip Scuderi, and Stephen Petteway. "Acid-Stabilized Plasmin as a Novel Direct-Acting Thrombolytic." In Production of Plasma Proteins for Therapeutic Use. John Wiley & Sons, Inc., 2012. http://dx.doi.org/10.1002/9781118356807.ch18.

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Setchell, K. D. R., N. Heaton, G. Mukadam, et al. "Intravenous use of ursodeoxycholic disulphate — A unidirectional bile acid, for hepatoprotection in liver transplantation and total parenteral nutrition-associated cholestasis." In Bile Acid Biology and Therapeutic Actions. Springer Netherlands, 2009. http://dx.doi.org/10.1007/978-1-4020-9644-0_36.

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May, T., and B. Rambeck. "Prediction of the Free Serum Concentrations of Phenytoin, Phenobarbital, Carbamazepine, and Carbamazepine-10,11-epoxide in Patients on Valproic Acid Co-medication." In Recent Developments in Therapeutic Drug Monitoring and Clinical Toxicology. CRC Press, 2023. http://dx.doi.org/10.1201/9781003418153-64.

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Meldrum, B. S. "Pharmacology of Excitatory Amino Acid Antagonists and their Possible Therapeutic Use in Neurological Disease." In Neurobiology of Amino Acids, Peptides and Trophic Factors. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4613-1721-0_5.

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Gómez, Noelia, Sandy Gavilanes, Inés Malo, and Mónica Espadero. "In vitro Evaluation of Antimicrobial Activity from the Methanolic Extracts of Taraxacum officinale and Melissa officinalis on Staphylococcus aureus." In Lecture Notes in Networks and Systems. Springer Nature Switzerland, 2025. https://doi.org/10.1007/978-3-031-87065-1_23.

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Abstract The use of plants has been increasing by the presence of bioactives, which is an opportunity in the creation of products such as medicines, food and cosmetics. Taraxacum officinale (Dandelion) and Melissa officinalis (Toronjil), are cosmopolitan species with great therapeutic potential, traditionally used for their anti-inflammatory, antioxidant and antimicrobial activity. Therefore, this research evaluates the antimicrobial activity of the methanol extracts of Taraxacum officinale and Melissa officinalis on Staphylococcus aureus using in vitro tests. Analyzes of secondary metabolites
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Sanches, Marsal, Rodrigo Machado-Vieira, and Jair C. Soares. "Pharmacotherapy of mood disorders." In Landmark Papers in Psychiatry, edited by Elizabeth Ryznar, Aderonke B. Pederson, Mark A. Reinecke, and John G. Csernansky. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198836506.003.0008.

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This chapter comprises a critical analysis of the main papers addressing the treatment of mood disorders (depressive disorder and bipolar disorder) from a historical standpoint. It begins with the first paper, authored by John Cade in the late 1940s, describing the use of lithium salts in the treatment of mania. Subsequently, it takes the reader on a journey over the antidepressant discovery process, starting with imipramine in the 1950s until the advent of fluoxetine in the 1970s and its ultimate incorporation into the therapeutic arsenal in the 1980s. It later approaches one of the first stu
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Li, Cong, Huijing Chen, Qijia Tan, et al. "The therapeutic and neuroprotective effects of an antiepileptic drug valproic acid in glioma patients." In Neuropharmacology of Neuroprotection. Elsevier, 2020. http://dx.doi.org/10.1016/bs.pbr.2020.09.008.

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Asadi-Pooya, Ali A., and Michael R. Sperling. "Antiepileptic Drugs in Patients on Chemotherapy or Immunosuppressive Therapy." In Antiepileptic Drugs. Oxford University PressNew York, NY, 2009. http://dx.doi.org/10.1093/oso/9780195368215.003.0019.

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Abstract Chemotherapeutic agents may lose effectiveness when enzyme-inducing antiepileptic drugs (AEDs) are prescribed because many chemotherapeutic agents are also metabolized by the cytochrome P-450 enzyme system. These AEDs include phenobarbital, primidone, phenytoin, and carbamazepine, as well as excarbazepine and topiramate in higher doses. On the other hand, enzyme-inhibiting AEDs, such as valproic acid, may amplify hematologic and other toxicities of chemotherapeutic agents (e.g., nitrosoureas or etoposide). It is therefore advisable to use AEDs that do not interfere with the cytochrome
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Macchi, Zachary, and Nathan Boehr. "Selecting the Anticonvulsant as an Adjuvant Analgesic." In Pain. Oxford University Press, 2022. http://dx.doi.org/10.1093/med/9780197542873.003.0011.

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Patients with malignant brain tumors commonly develop seizures at all stages of disease. In the home hospice setting, choosing the anticonvulsant to control seizures and simultaneously augment pain control requires weighing the patients’ goals of care, medical comorbidities, and concomitant medications. For acute seizure management, benzodiazepines like midazolam and diazepam come in formulations that are easy to use by informal caregivers and avoid the need for intravenous access. The best understood medications for long-term use in more prolonged end-of-life courses include gabapentin and pr
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Actas de conferencias sobre el tema "Valproic acid therapeutic use"

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Dougherty, John, Emily Schaefer, Ryan Niemeier, Erin Koch, Craig Cady, and Kalyani Nair. "Effect of Valproic Acid on Cell Proliferation of Wharton’s Jelly MSC in PCL Nanofiber Scaffolds." In ASME 2013 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/imece2013-65041.

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The field of tissue engineering and regenerative medicine is an interdisciplinary field that applies the principles of engineering and life sciences toward the development of biological substitutes that restore, maintain, or improve tissue function or a whole organ. The process involves seeding cells onto biocompatible scaffolds that temporarily act as a supporting structure for cells to attach and grow. Scaffolds for tissue regeneration must present a viable microenvironment for the living cells to adhere, proliferate, and exhibit the necessary tissue function. Electrospinning is an emerging
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Lipecki, Y., and E. Haen. "15 A HPLC-UV/VIS method for the quantification of valproic acid in human serum." In XIVth Symposium of the Task Force Therapeutic Drug Monitoring of the AGNP. © Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0040-1710123.

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Kocjančič, Boštjan, and Ema Kocjančič. "The Use of Tranexamic Acid in Orthopaedic Surgery." In Socratic Lectures 8. University of Lubljana Press, 2023. http://dx.doi.org/10.55295/psl.2023.i9.

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New surgical techniques (minimally invasive surgery – (MIS), laparoscopic surgery), meticulous consideration of haemostasis, use of robots, Cell Saver and tranexamic acid, new transfusion criteria and single red blood cell (RBC) unit ordering have greatly changed clinical practices. Implementation of these therapeutic options along with other practices has significantly contributed to the effectiveness of the patient blood management approach to surgical patients. In recent years use of anti-fibrinolytic agent tranexamic acid (TXA) has been introduced at our department and intravenous administ
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Giannini, C., M. Conti, D. Paoletti, et al. "5PSQ-051 Analysis of use and therapeutic adherence among patients treated with bempedoic acid at a local health authority." In 29th EAHP Congress, Copenhagen, Denmark, 12-13-14 March 2025, Person centred pharmacy — Navigating digital health. British Medical Journal Publishing Group, 2025. https://doi.org/10.1136/ejhpharm-2025-eahp.349.

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Ifkovits, Jamie L., Elena Tous, Masato Morita, Joseph H. Gorman, Robert C. Gorman, and Jason A. Burdick. "Injectable Hyaluronic Acid Hydrogels to Attenuate Post-Infarction Left Ventricular Remodeling." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206461.

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Several investigators have been successful in reducing the adverse left ventricular (LV) remodeling and expansion that exists in response to myocardial infarction (MI) via the use of various restraints, such as knitted polypropylene meshes [1] and injectable materials [2]. A recent finite element model simulation of the theoretical impact of injection of a material into the myocardium after MI confirmed the suspected stress reduction potential of intramyocardial infarct stiffening with an acellular, non-contractile material. As peak LV wall stress has been implicated in the pathogenesis of pos
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Lacombe, RJ Scott. "High-oleic Ready-to-use Therapeutic Food with or Without Docosahexaenoic Acid Supports Normal Growth and Recovery in Malnourished Malawian Children: A Randomized Controlled Trial." In Virtual 2021 AOCS Annual Meeting & Expo. American Oil Chemists’ Society (AOCS), 2021. http://dx.doi.org/10.21748/am21.103.

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Borges, Lucas Paulo Andrade, Henrique Nascimento Dourado, Joanna Sousa da Fonseca Santana, Laís Fe Matos Galvão, Gabriel Vianna Pereira Aragão, and Graccho Cardoso de Silva Neto. "Diabetic striatopathy: a case report." In XIV Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s1.785.

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Introduction: Striatopathy or non-ketonic hyperglycemia is a rare etiology, but well reported in the literature, of involuntary movements in patients with diabetes mellitus, being characterized by affecting, in general, elderly patients with hemicorrea-hemiballismus. The aim is to report a clinical case of the development of movement disorder caused by hyperglycemia. Case report: Patient E.J.D.O, 71-year-old, male, hypertensive and dyslipidemic. Admitted to the emergency room with a history of involuntary movements in the upper left limb for about two months, with recent worsening. Upon admiss
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Sovrlić, Miroslav, Nedeljko Manojlović, Marijana Kosanić, Aleksandar Kočović, Jovica Tomović, and Perica Vasiljević. "Lichenochemical analysis and in vitro antioxidant activity of extracts and gyrophoric acid from lichen Umbilicaria grisea." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.515s.

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This research investigates the chemical composition, total phenolic and flavonoid content, and antioxidant activity of acetone, methanol, and ethanol extracts of the lichen Umbilicaria grisea, and its major secondary metabolite, gyrophoric acid. The extracts were analyzed using high-performance liquid chromatography (HPLC-UV) and spectrophotometric assays. The results showed significant levels of phenolic compounds and flavonoids, which contribute to the lichen’s antioxidant potential. The antioxidant activity was evaluated using in vitro assays such as DPPH and ABTS radical scavenging activit
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Danesh, B. J. Z., A. R. Saniabadi, R. I. Russell, G. D. O. Lowe, and C. D. Forbes. "COMPARISON OF THE EFFECT OF ASPIRIN (ASA) AND CHOLINE MAGNESIUM TRISALICYLATE (CMT) ON PLATELET AGGREGATION IN WHOLE BLOOD EX-VIVO." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644866.

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Suppression of platelet aggregation by ASA limits the therapeutic use of this drug as an analgesic in patients with bleeding tendencies. CMT is a non-acetylated salicylate derivative with analgesic and anti-inflammatory effect similar to that of ASA. We compared platelet aggregation in human whole blood ex-vivo, three hours after ingestion of ASA and. CMT. Using a whole blood platelet counter, platelet aggregation was quantified by measuring the fall in the number of single platelets at peak aggregation in response to collagen (lμg/ml) arachidonic acid (AA, 0.5 mM) as well as spontaneous aggre
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Verdes, Anastasia, Elena Gorincioi, Lucian Lupascu, Gheorghe Duca, and Fliur Macaev. "Targeting the bioactive dihydropyrimidines by ecofriendly procedure of biginelli reaction: study case of monastrol." In Scientific seminar with international participation "New frontiers in natural product chemistry". Institute of Chemistry, Republic of Moldova, 2023. http://dx.doi.org/10.19261/nfnpc.2023.ab24.

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Biologically active compounds decorated with dihydropyridine moiety are counted amongst the numerous broad-spectrum therapeutic agents that explain the increasing role of this scaffold in rational drug design [1]. The Biginelli reaction is a multicomponent reaction of aldehyde, (thio)urea, and ß-ketoester, involving Mannich reaction in the first step, which produces multifunctionalized 3,4-dihydropyrimidin-2-(1H)-ones and related heterocyclic compounds [2]. The attractiveness of this acid-catalyzed one-pot condensation reaction lies in the simplicity of grafting the substituent into the struct
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Informes sobre el tema "Valproic acid therapeutic use"

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Sentcоv, Valentin, Andrei Reutov, and Vyacheslav Kuzmin. Electronic training manual "Acute drug poisoning". SIB-Expertise, 2024. http://dx.doi.org/10.12731/er0776.29012024.

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The widespread use in modern medicine of hypnotics, sedatives, tricyclic antidepressants, antihypertensive drugs and antipyretics, even in therapeutic dosages, sometimes leads to adverse consequences for the patient. Accidental or intentional excess of therapeutic dosages leads to severe poisoning. This fact indicates the high relevance of doctors’ knowledge of any clinical specialty and the treatment of poisoning by these groups of drugs. This electronic educational resourse consists of six theoretical educational modules: poisoning with barbituric acid derivatives, acute poisoning with tricy
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