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Articles de revues sur le sujet « 378.1/2/092 b »

Auteur : Grafiati

Publié le 25 juillet 2024

Mis à jour le 31 juillet 2025

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1

Korphaisarn, Krittiya, Kosin Wirasorn, Suebpong Tanasanvimon, et al. "Efficacy and safety of durvalumab plus tremelimumab for unresectable hepatocellular carcinoma in Thailand: A real-world multicenter observational study." Journal of Clinical Oncology 43, no. 4_suppl (2025): 539. https://doi.org/10.1200/jco.2025.43.4_suppl.539.

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539 Background: Durvalumab plus tremelimumab (Durva/Treme) andatezolizumab plus bevacizumab are preferable first-line therapy for unresectable hepatocellular carcinoma (uHCC). This study aimed to evaluate the efficacy and safety of Durva/Treme in real world setting. Methods: Fifty patients with uHCC who enrolled in the expanded access program (EAP) for Durva/Treme as the first-line treatment from 12 centers in Thailand were included. Analysis was assessed for objective response rate (ORR), survival, and adverse events. We also compared data with the HIMALAYA study. Results: Median follow-up ti

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Masui, Rino, Yoshiki Yokoyama, Masayoshi Watanabe, and Shiro Seki. "Preparation of Low Melting Temperature Lithium-Based Binary Salts and Their Physicochemical Properties." ECS Meeting Abstracts MA2024-02, no. 57 (2024): 3869. https://doi.org/10.1149/ma2024-02573869mtgabs.

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Achieving carbon neutrality demands the development of high-performance Li-ion secondary batteries (LIB), driven by a pressing need for electric vehicles and renewable energy storage. Molten salt electrolytes offer promise for enhancing safety and performance due to their exceptional thermal stability and high Li+ transport numbers(1). However, the high operating temperature range of molten salts, stemming from high melting temperatures, presents a significant challenge. In this study, we propose Li salts with low melting points achieved through increased entropy and eutectic effects by mixing

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Yin, X. Y., R. L. Zhang, H. Y. Zheng, et al. "OP0159 GENETICALLY DETERMINED CAUSAL RELATIONSHIP BETWEEN GOUT AND CARDIOVASCULAR DISEASE." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 105. http://dx.doi.org/10.1136/annrheumdis-2023-eular.4227.

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BackgroundGout is a common inflammatory arthritis caused by monosodium urate deposits around the joints[1]. The risk of cardiovascular events, including death, is substantially higher in people with gout than in those without gout[2]. Although epidemiological studies have reported a positive correlation between circulating urate levels and cardiac metabolic diseases, the causal relationship between gout and cardiovascular diseases(CVD) is still uncertain[3].ObjectivesThis study aimed to explore the causal relationship between gout and CVD from the genetic level. We examined the potential effec

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Abdallah, Abdullah I., Nicola J. Commander, Martin J. Woodward, Steve Spencer, C. Anthony Hart, and Craig Winstanley. "Type III Secretion Homologs Are Present in Brucella melitensis , B. ovis , and B. suis biovars 1, 2, and 3." Current Microbiology 46, no. 4 (2003): 241–45. http://dx.doi.org/10.1007/s00284-002-3789-3.

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Ghoneim, M. M., and A. Tawfik. "Voltammetric studies and assay of the anti-inflammatory drug ketoprofen in pharmaceutical formulation and human plasma at a mercury electrode." Canadian Journal of Chemistry 81, no. 8 (2003): 889–96. http://dx.doi.org/10.1139/v03-092.

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The electrochemical reduction of the anti-inflammatory drug ketoprofen was studied in a Britton-Robinson (B-R.) buffer series of pH 211 using dc-polarography, cyclic voltammetry, and coulometry techniques. The electrode reaction pathway of the drug at the dropping mercury electrode was proposed and discussed. A new adsorptive cathodic stripping square-wave voltammetric procedure was optimized for the assay of bulk drug in a B-R. buffer of pH 2.0. The peak current was linear with the drug concentration over the ranges 2 × 109 to 2 × 107 M of the bulk drug, using a 60 s accumulation time peri

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Gidney, M. A. J., D. R. Bundle, A. Godard та B. W. Griffiths. "Development and characterization of monoclonal antibodies to pregnancy-specific β1-glycoprotein". Canadian Journal of Biochemistry and Cell Biology 63, № 7 (1985): 737–42. http://dx.doi.org/10.1139/o85-092.

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Six monoclonal antibodies were developed to pregnancy-specific β1-glycoprotein (PSβ1G). Studies of ascitic fluid antibodies by a double-antibody radioimmunoassay (RIA) included an evaluation of titers, dose–response parameters, and mass action properties. Four of the antibodies demonstrated moderate to high titers ranging from 1/40 000 to > 1/120 000, as determined by the specific binding of 125I-labeled PSβ1G. In inhibition studies utilizing a standard containing known quantities of placental PSβ1G, two of the antibodies (AR#11 and B#2) were highly sensitive and only slightly lower in this

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Gachango, E., W. Kirk, L. Hanson, A. Rojas, and P. Tumbalam. "First Report of Fusarium torulosum Causing Dry Rot of Seed Potato Tubers in the United States." Plant Disease 95, no. 9 (2011): 1194. http://dx.doi.org/10.1094/pdis-04-11-0291.

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Fusarium dry rot of potato (Solanum tuberosum L.) is a postharvest disease caused by several Fusarium species and is of worldwide importance. Thirteen species of Fusarium have been implicated in fungal dry rots of potatoes worldwide. Among them, eight species have been reported in the northern United States (2). In Michigan potato production, F. sambucinum was the predominant species reported to be affecting seed potato in storage and causing seed piece decay after planting (3). Some previous identifications of F. sambucinum as dry rot may have been F. torulosum since F. torulosum was previous

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Yang, Xu, Bowen Chen, Yanyu Wang, et al. "Lenvatinib plus PD-1 inhibitors in 378 unresectable hepatocellular carcinoma: A large real-world study from two centers." Journal of Clinical Oncology 40, no. 16_suppl (2022): e16155-e16155. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e16155.

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e16155 Background: Combining lenvatinib (a multikinase inhibitor) with programmed cell death protein-1 (PD-1) inhibitor has been explored in Unresectable hepatocellular carcinoma (uHCC) in phase 1b trials. This study aimed to investigate the real-word efficacy and safety of lenvatinib plus PD-1 inhibitor for large Chinese patients uHCC cohorts. Methods: BCLC stage B or C uHCC patients were included. Data was collected from Oct 2017 to Nov 2021 retrospectively. Patients were treated with lenvatinib and PD-1 inhibitor (pembrolizumab or nivolumab or camrelizumab or sintilimab or toripalimab or ti

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Harb, Wael, Mansoor N. Saleh, Kyriakos P. Papadopoulos, et al. "Clinical Trial Results from the Subgroup of Lymphoma/CLL in a Phase 1 Study of ARQ 092, a Novel Pan AKT-Inhibitor." Blood 126, no. 23 (2015): 5116. http://dx.doi.org/10.1182/blood.v126.23.5116.5116.

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Abstract Background: ARQ 092 is an oral allosteric, potent and selective AKT inhibitor with in vitro and in vivo activity in solid and hematological tumors. ARQ 092-101, the first clinical trial of ARQ 092, has enrolled more than 100 subjects with advanced solid tumors or recurrent malignant lymphoma. As reported previously, the dose escalation portion of the study has been completed and two dosing schedules (intermittent and weekly), are recommended for phase 2 studies. The recommended phase 2 dose (RP2D) for the intermittent dosing schedule is 200 mg once daily (QD) (one week on, one week of

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Shen, Jian, Chun Chang, Jie Ma, and Qiang Feng. "Potential of Circulating Proangiogenic MicroRNAs for Predicting Major Adverse Cardiac and Cerebrovascular Events in Unprotected Left Main Coronary Artery Disease Patients Who Underwent Coronary Artery Bypass Grafting." Cardiology 146, no. 3 (2021): 400–408. http://dx.doi.org/10.1159/000509275.

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<b><i>Objective:</i></b> This study aimed to explore the association of 14 proangiogenic microRNAs (miRNAs) with major adverse cardiac and cerebrovascular events (MACCE) occurrence in unprotected left main coronary artery disease (ULMCAD) patients who underwent coronary artery bypass grafting (CABG). <b><i>Methods:</i></b> A total of 196 ULMCAD patients who underwent first ever CABG were recruited. The peripheral blood samples were collected prior to CABG, and then plasma samples were separated to detect expressions of 14 proangiogenic miRNAs by

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GLENDINNING, PAUL, and NIKITA SIDOROV. "The doubling map with asymmetrical holes." Ergodic Theory and Dynamical Systems 35, no. 4 (2013): 1208–28. http://dx.doi.org/10.1017/etds.2013.98.

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AbstractLet $0\lt a\lt b\lt 1$ and let $T$ be the doubling map. Set $ \mathcal{J} (a, b): = \{ x\in [0, 1] : {T}^{n} x\not\in (a, b), n\geq 0\} $. In this paper we completely characterize the holes $(a, b)$ for which any of the following scenarios hold: (i) $ \mathcal{J} (a, b)$ contains a point $x\in (0, 1)$; (ii) $ \mathcal{J} (a, b)\cap [\delta , 1- \delta ] $ is infinite for any fixed $\delta \gt 0$; (iii) $ \mathcal{J} (a, b)$ is uncountable of zero Hausdorff dimension; (iv) $ \mathcal{J} (a, b)$ is of positive Hausdorff dimension. In particular, we show that (iv) is always the case if $$

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Semenova, Lioubov I., and Allan H. White. "Structural Systematics of Rare Earth Complexes. XVII Hydrated 1 : 1 Adducts of 2,2′:6′,2″-Terpyridine with the Lanthanoid(III) Bromides and Some Binuclear Hydroxy-Bridged Dimers." Australian Journal of Chemistry 52, no. 6 (1999): 539. http://dx.doi.org/10.1071/ch98048.

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Room-temperature single-crystal X-ray structural characterizations are recorded for hydrated lan- thanoid(III) bromide/2,2′:6′,2″-terpyridine (tpy) (1 : 1) complexes, showing all to be ionic and of the form [(tpy)Ln(OH2)x]Br3.yH2O, where x and y are 6 and 1 for the isomorphous series Ln = La(-)Er (and intermediate members, by presumption), and 5 and various values for Ln = Tm, Yb, Lu. Crystals of [(tpy)Ln(OH2)6]Br3.H2O are monoclinic, P 21/c, a ≈ 8·5, b ≈ 18, c ≈ 16·3 Å, β ≈ 108°, Z = 4; for Ln = La, Er, conventional R values on |F| were 0·048, 0·080 for No 4027, 1347 ‘observed’ (I > 3σ(I))

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Santoshkumar, S., N. D. Satyanarayana, R. Anantacharya, and P. Sameer. "SYNTHESIS, ANTIMICROBIAL, ANTITUBERCULAR AND CHEMINFORMATIC STUDIES OF 2-(1-BENZOFURAN-2-YL)-N'-[(3Z)-2-OXO-1, 2-DIHYDRO-3H-INDOL-3-YLIDENE] QUINOLINE-4-CARBOHYDRAZIDE AND ITS DERIVATIVES." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 5 (2017): 260. http://dx.doi.org/10.22159/ijpps.2017v9i5.17564.

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Objective: Synthesis of novel 2-(1-benzofuran-2-yl)-N'-[(3Z)-2-oxo-1, 2-dihydro-3H-indol-3-ylidene] quinoline-4-carbohydrazide and its derivatives for antimicrobial and antitubercular activity.Methods: Synthesis was carried out using the general method and the structures were confirmed by IR, 1H-NMR, [13]C-NMR and mass spectral analysis. The antibacterial activity was carried by agar well diffusion method, antifungal activity was performed by poison food technique and antitubercular activity was carried out by Microplate Alamar Blue Assay (MABA) method with the help of H37Rv. In silico absorpt

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Guru, S. Gadaginamath, R. Puja Shashikant, S. Donawade Dundappa, and R. Kavali Rajesh. "Synthesis and antimicrobial activity of new linearly fused 6-substituted-3,8-diacetyl-4, 7-dimethyl-2H -pyrano[ 6,5-f]indoles, their chemoselective bromnination and synthesis of 3-thiazolylpyranoindoles." Journal of Indian Chemical Society Vol. 81, Oct 2004 (2004): 865–67. https://doi.org/10.5281/zenodo.5832567.

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P.G. Department of Studies' in Chemistry, Karnatak University, Dharwad-580 003, India <em>E-mail</em> : profgmath@yahoo.co.in Indian Institute of Science, Bangalore-560 012, India Korea Advanced Instituted of Science and Technology (KAIST), Taejon 305-701, Korea <em>Manuscript received 1 December 2003, accepted 17 May 2004</em> When 1-substituted-3,6-diacetyl-5-hydroxy-2-methylindoles 1 (a, b) were reacted with ethyl acetoacetate in presence of 2- methylpiperidinc produced new 6-substituted-3,8-diacetyl-4,7-dimethyl-2<em>H</em>-pyrano[6,5-<em>f</em>]indole-2-ones 2(a,b). Then these compoun

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Caldwell, Gary, Richard Renneboog, and Paul Kebarle. "Gas phase acidities of aliphatic carboxylic acids, based on measurements of proton transfer equilibria." Canadian Journal of Chemistry 67, no. 4 (1989): 611–18. http://dx.doi.org/10.1139/v89-092.

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Measurements of the gas phase proton transfer equilibrium [1]: AH + B− = A− + BH with a pulsed electron high pressure mass spectrometer (PHPMS) lead to [Formula: see text] and [Formula: see text] data. These relative acidities are converted to the absolute acidities [2]: AH = A− + H+bycalibration of the relative [Formula: see text] and [Formula: see text] scale to the known values for [Formula: see text] and [Formula: see text] of a reference compound(HCl). Earlier determinations that included 16 aliphatic AH are extended in the present work and provide data for 47 aliphatic carboxylic acids.

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Pavić, Slađana, Marija Antić, Radmila Sparić, and Aleksandra Pavić. "Clinical course of coxsackievirus B (1-6) infection." PONS - medicinski casopis 17, no. 1 (2020): 3–7. http://dx.doi.org/10.5937/pomc17-25015.

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Objective. Coxsackievirus B (1-6) infections are the common infections of children and adults. Clinical manifestations include fever, aseptic meningitis, pleurodinia, myocarditis, gastroenterocolitis, maculous exanthem. The clinical course of the infection is influenced by the characteristics of the host, as well as the virus serotype. The pathogenesis of the diseases is explained by the immune mediated mechanism and the direct cytotoxic effect of the virus. Methods. Retrospectively analyzed virus serotype, clinical and biochemical data in patients with coxsackievirus B (1-6) infection. Patien

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Bowmaker, Graham A., Frances M. M. Hannaway, Peter C. Junk, Aaron M. Lee, Brian W. Skelton, and Allan H. White. "Synthetic, Structural and Vibrational Spectroscopic Studies in Bismuth(III) Halide/N,N′-Aromatic Bidentate Base Systems. IV Bismuth(III) Halide/N,N′-Bidentate Ligand (1 : 1) Systems." Australian Journal of Chemistry 51, no. 4 (1998): 325. http://dx.doi.org/10.1071/c97039.

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Room-temperature single-crystal X-ray studies are recorded for a number of adducts of BiX3 and N,N′-bidentate ligand (2,2′-bipyridine (bpy) or 1,10-phenanthroline (phen)), devoid of coordinated solvent. BiBr3/bpy/MeCN (1 : 1 : 1) is triclinic P-1, a 12·129(2), b 9·955(4), c 7·748(1) Å, α 73·14(2), β 77·34(1), γ 69·79(2)°, Z = 2; conventional R on |F| was 0·036 for No 2252 independent ‘observed’ (I > 3σ(I)) reflections. The phen analogue is isomorphous, a 11·586(3), b 10·839(6), c 7·769(10) Å, α 73·70(7), β 76·67(7), γ 70·34(4)°, Z = 2, R 0·042 for No 800. BiI3/bpy (1 : 1) is triclinic, P-1,

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Nozaki, Kenji, Hiroyuki Sugahara, Shuji Ueda, et al. "Elevated Serum Soluble Interleukin-2 Receptor Level Is a Useful Prognostic Factor for Disease-Specific Overall Survival in Patients with Newly Diagnosed Follicular Lymphoma before Initiation of Treatment." Blood 134, Supplement_1 (2019): 3985. http://dx.doi.org/10.1182/blood-2019-126399.

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Introduction: Serum soluble interleukin-2 receptor (sIL-2R) is recognized as a tumor-related biomarker of malignant lymphomas, including follicular lymphoma (FL). The objective of this study is to assess the prognostic significance of pretreatment serum sIL-2R level for disease-specific overall survival (DSS) in patients with FL. Methods: We retrospectively analyzed medical records of our 10 individual institutions to identify all patients (pts) ≥ 18 years old with newly diagnosed FL between 01/01/2008 and 12/31/2018. Only pts with FL grade 1-3b, confirmed at pathological review, were included

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Rajendran, Rajam, and Yoshiyuki Ohta. "Binding activity of Natto (a fermented food) and Bacillus natto isolates to mutagenic-carcinogenic heterocyclic amines." Canadian Journal of Microbiology 47, no. 10 (2001): 935–42. http://dx.doi.org/10.1139/w01-094.

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The fermented food, whole meal Natto, viscous polymeric material from Natto, Natto bean, cooked soya bean, and 28 bacterial isolates from Natto were studied for their binding capacity to foodborne mutagenic-carcinogenic heterocyclic amines. The mutagenic heterocyclic amines used were Trp-P-1 (3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole); Trp-P-2 (3-amino-1-methyl-5H-pyrido(4,3-b)indole); Glu-P-1 (2-amino-6-methyldipyrido(1,2-a:3'2'-d)imidazole); PhIP (2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine); IQ (2-amino-3-methylimidazo(4,5-f)quinoline); MeIQ (2-amino-3,4-dimethylimidazo(4,5-f)quinoxal

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Bowmaker, Graham A., Peter C. Junk, Aaron M. Lee, Brian W. Skelton, and Allan H. White. "Synthetic, Structural and Vibrational Spectroscopic Studies in Bismuth(III) Halide/N,N′-Aromatic Bidentate Base Systems. I Large-Cation (2,2′-Bipyridinium and 1,10-Phenan- throlinium) Salts of Polyhalobismuthate(III) Ions." Australian Journal of Chemistry 51, no. 4 (1998): 293. http://dx.doi.org/10.1071/c97036.

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Syntheses and room-temperature single-crystal X-ray studies are recorded for a variety of salts of cations derived from protonated 2,2′-bipyridine and 1,10-phenanthroline (bpyH+ and phenH+) with polyhalobismuthate(III) anions. ‘[(phenH)(phenH2)(H2O)2] [BiCl6]’ is triclinic, P-1, a 9·791(1), b 9·338(3), c 8·311(3) Å, α 73·46(3), β 69·71(2), γ 86·36(2)°, Z = 1; conventional R on |F| was 0·027 for No 4852 independent ‘observed’ (I > 3σ(I)) reflections. [BiCl6]3- is closely octahedral, accompanied by an interesting protonation/hydrogen-bonding array among the other moieties. The latter comment

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McDonagh, Andrew M., Mark G. Humphrey, and David C. R. Hockless. "Preparation of cis- and trans-[OsCl2(Me2SO)4], and X-Ray Crystal Structures of the All-S-Bound Isomers." Australian Journal of Chemistry 51, no. 9 (1998): 807. http://dx.doi.org/10.1071/c98017.

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Efficient syntheses of the cis and trans isomers of [OsCl2(Me2SO)4] are reported. While a structural study of thetrans isomer confirms the spectroscopically assigned all-S-bound Me2SO configuration, a crystallographic determination of the cis isomer reveals a previously unheralded all-S-bound Me2SO geometry, in contrast to the spectroscopically inferred configuration predominant in solution which has one O-bound ligand. Fortrans-[OsCl2(Me2SO)4], crystals are tetragonal, space group I 4/m, with a 9·092(2), c 11·212(3) Å, Z 2, 566 unique reflections (34 parameters), converging at R 0·026 and Rw

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Burkhardt, Birgit, Ilske Oschlies, Wolfram Klapper, et al. "Non-Hodgkin Lymphoma in Adolescents: Experiences in 378 Adolescent NHL Patients Treated According to Pediatric NHL-BFM Protocols." Blood 114, no. 22 (2009): 102. http://dx.doi.org/10.1182/blood.v114.22.102.102.

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Abstract Abstract 102 There are considerable differences with respect to incidence, biology, treatment and outcome of Non-Hodgkin Lymphoma (NHL) between children and adults. Patients of adolescent age are forming a separate group that falls between those categories. Even though recent reports pay increasing attention to these patients, the impact of adolescent age on the characteristics and outcome of NHL remains yet to be determined. Therefore, the current analyses aimed to analyze the outcome of adolescents treated according to BFM protocols for childhood NHL. Patients were treated according

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Magid Diefenbach, Catherine S., Jonathan B. Cohen, Wael A. Harb, et al. "Results of a completed phase I study of LAM-002 (apilimod dimesylate), a first-in-class phosphatidylinositol-3-phosphate 5 kinase (PIKfyve) inhibitor, administered as monotherapy or with rituximab or atezolizumab to patients with previously treated follicular lymphoma or other B-cell cancers." Journal of Clinical Oncology 38, no. 15_suppl (2020): 8017. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.8017.

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8017 Background: LAM-002 is a selective inhibitor of PIKfyve that disrupts lysosomal homeostasis, inducing cytotoxicity in B-cell lymphoma models as monotherapy or with anti-CD20 or anti-PDL1 antibodies (Gayle et al., Blood 2017;129(13):1768). Methods: In this study, patients received LAM-002 orally 2-3 times per day (BID or TID) in a 3+3 escalation. Additional patients received LAM-002 125 mg BID as monotherapy; with rituximab 375 mg/m2 intravenously (IV) and or subcutaneously weekly (Q1W) x 4 → Q8W x 4; or atezolizumab 1200 mg IV Q3W until disease progression or unacceptable toxicity. Pharma

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Sulistyorini, Anik, Tjandrakirana Tjandrakirana, and Soetjipto Soetjipto. "PENGEMBANGAN PERANGKAT PEMBELAJARAN IPA MODEL GUIDED INQUIRY UNTUK MELATIHKAN KETERAMPILAN PROSES SAINS DAN MENINGKATKAN HASIL BELAJAR SISWA SMP." JPPS (Jurnal Penelitian Pendidikan Sains) 6, no. 1 (2017): 1167. http://dx.doi.org/10.26740/jpps.v6n1.p1167-1174.

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This research was done by developing science learning materials (lesson plans, student’s worksheets, student’s book, and learning achivement test) based on guided inquiry learning model using 4D development model to facilitate student’s science process skills and improving student’s learning achivement on environmental pollutions matter. The objective of this research was to trial learning materials in 35 of junior high school’s students with one group pretest-postest design. Results were analyzed by descriptive quantitative-qualitative are: (1) Validity of learning material valid category (3.

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Fernandes, Tiago, Valério G. Baraúna, Carlos E. Negrão, M. Ian Phillips, and Edilamar M. Oliveira. "Aerobic exercise training promotes physiological cardiac remodeling involving a set of microRNAs." American Journal of Physiology-Heart and Circulatory Physiology 309, no. 4 (2015): H543—H552. http://dx.doi.org/10.1152/ajpheart.00899.2014.

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Left ventricular (LV) hypertrophy is an important physiological compensatory mechanism in response to chronic increase in hemodynamic overload. There are two different forms of LV hypertrophy, one physiological and another pathological. Aerobic exercise induces beneficial physiological LV remodeling. The molecular/cellular mechanisms for this effect are not totally known, and here we review various mechanisms including the role of microRNA (miRNA). Studies in the heart, have identified antihypertrophic miRNA-1, -133, -26, -9, -98, -29, -378, and -145 and prohypertrophic miRNA-143, -103, -130a,

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Javed, Muhammad Babar, Zaffar Malik, Muhammad Kamran, et al. "Assessing Yield Response and Relationship of Soil Boron Fractions with Its Accumulation in Sorghum and Cowpea under Boron Fertilization in Different Soil Series." Sustainability 13, no. 8 (2021): 4192. http://dx.doi.org/10.3390/su13084192.

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Boron (B) is an essential micronutrient in the growth of reproductive plant parts. Its deficiency and/or toxicity are widespread in arid and semi-arid soils with low clay contents. This study was planned to determine the response of sorghum (Sorghum bicolor L., non-leguminous crop) and cowpea (Vigna sinensis L., leguminous crop) to boron (0, 2, 4, and 16 µg g−1) on four distinct soil series from Punjab, Pakistan i.e., Udic Haplustalf (Pindorian region), Typic Torrifluvent (Shahdra region), Halic Camborthid (Khurianwala region), and Udic Haplustalf (Gujranwala region). Overall, there was a sign

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Wondmagegn, Bereket, Zerihun Achiso, and Abate Abera. "Effects of NPSB Fertilizers Rate on the Yield of Common Bean (Phaseolus vulgaris L.) at Tocha District, Southern Ethiopia." European Journal of Theoretical and Applied Sciences 2, no. 3 (2024): 639–45. http://dx.doi.org/10.59324/ejtas.2024.2(3).48.

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Use of balanced nutrition means supplying other essential plant nutrients in adequate amount and proportion along with N and P. This implies N and P fertilizers are not the only yield determining nutrients but also S, B, and Cu nutrients are important nutrient for crop production. A trial was conducted in Tocha District to evaluate the rate of blended fertilizers to improve Common bean yield during main cropping season of 2019 and 2020. The experiment consists of seven treatment including (1) control, (2) NPSB: 18.9-37.7-6.95-0.1 (3) NPSB: 28.35-56.55-10.425-0.15 (4) NPSB: 37.8-75.4-13.9-0.2,

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Bereket, Wondmagegn, Achiso Zerihun, and Abera Abate. "Effects of NPSB Fertilizers Rate on the Yield of Common Bean (Phaseolus vulgaris L.) at Tocha District, Southern Ethiopia." European Journal of Theoretical and Applied Sciences 2, no. 3 (2024): 639–45. https://doi.org/10.59324/ejtas.2024.2(3).48.

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Use of balanced nutrition means supplying other essential plant nutrients in adequate amount and proportion along with N and P. This implies N and P fertilizers are not the only yield determining nutrients but also S, B, and Cu nutrients are important nutrient for crop production. A trial was conducted in Tocha District to evaluate the rate of blended fertilizers to improve Common bean yield during main cropping season of 2019 and 2020. The experiment consists of seven treatment including (1) control, (2) NPSB: 18.9-37.7-6.95-0.1 (3) NPSB: 28.35-56.55-10.425-0.15 (4) NPSB: 37.8-75.4-13.9-0.2,

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Ritchlin, C. T., P. Rahman, P. Helliwell, et al. "AB0538 POOLED SAFETY RESULTS FROM TWO PHASE-3 TRIALS OF GUSELKUMAB IN PATIENTS WITH PSORIATIC ARTHRITIS THROUGH 1 YEAR." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1300–1301. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1334.

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Background:DISCOVER 1 & 2, two double-blind, phase-3, psoriatic arthritis (PsA) trials of guselkumab (GUS, an IL-23 inhibitor), demonstrated significant improvement with GUS vs placebo (PBO) in signs and symptoms of PsA, with good tolerability, at week (w) 24 during the PBO-controlled period.1,2 Beyond w24, all patients (pts) switched to GUS. Continued treatment maintained efficacy through w52.3,4Objectives:To describe pooled safety results from the DISCOVER 1 & 2 trials through 1-year of GUS treatment.Methods:Adults with active PsA (DISCOVER 1: ≥3 tender/swollen joints and C-Reactive

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Murayama, Kayoko, Toru Kiguchi, Koji Izutsu, et al. "Bendamustine plus rituximab in Japanese patients with relapsed or refractory diffuse large B-cell lymphoma." Annals of Hematology 101, no. 5 (2022): 979–89. http://dx.doi.org/10.1007/s00277-022-04801-2.

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AbstractThis single-arm phase 3 study was conducted to confirm the results of our phase 2 study of bendamustine (B)-rituximab (R) in patients with relapsed/refractory diffuse large B cell lymphoma (rrDLBCL). The primary endpoint was overall response rate (ORR). Autologous stem cell transplantation-ineligible rrDLBCL patients with ≤ 2 prior chemotherapy regimens received R 375 mg/m2 IV on day 1 and B 120 mg/m2/day IV on days 2 and 3 every 21 days up to 6 cycles. Thirty-eight patients with a median age of 74 years (range, 43–86) received BR. The ORR and complete response rates were 76.3% and 47.

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Abdalla, Marwah, Sumayya Shurovi, Michelle David, Talea Cornelius, Ari Shechter, and Joseph Schwartz. "0912 The Association Between Somatization and Sleep." SLEEP 47, Supplement_1 (2024): A391—A392. http://dx.doi.org/10.1093/sleep/zsae067.0912.

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Abstract Introduction Somatization, the experience of having somatic symptoms (e.g., pain, fatigue, dizziness) with resultant psychological distress, has been described among working adults and contributes to work-related absences. Whether somatization affects employees’ sleep quality and sleep duration is unclear. We examined the association of somatization with sleep quality and duration. Methods Data came from the 4th wave of the multi-site Worksite Blood Pressure Study, which assessed psychological factors and ambulatory blood pressure. A total of 472 participants without major cardiovascu

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DesRuisseaux, Libby A., Namita Mahtta, and Yana Suchy. "36 Dispersion vs. inconsistency: Investigating the relationship between different forms of intra-individual variability in community-dwelling older adults." Journal of the International Neuropsychological Society 29, s1 (2023): 716–17. http://dx.doi.org/10.1017/s1355617723008949.

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Objective:There are two forms of intra-individual variability (IIV) in the literature: inconsistency, or variability on one task across many time points, and dispersion, or variability across many tasks at one time point. These forms of IIV are often lumped together into one construct, but there is limited evidence supporting this practice, as few studies have examined the relationship between these measures. Additionally, it is not clear how stable these constructs are over time. Therefore, the goal of the present study was (1) to explore the relationship between (a) inconsistency and dispers

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Hallek, Michael, Guenter Fingerle-Rowson, Anna Maria Fink, et al. "Immunochemotherapy with Fludarabine (F), Cyclophosphamide (C), and Rituximab (R) (FCR) Versus Fludarabine and Cyclophosphamide (FC) Improves Response Rates and Progression-Free Survival (PFS) of Previously Untreated Patients (pts) with Advanced Chronic Lymphocytic Leukemia (CLL)." Blood 112, no. 11 (2008): 325. http://dx.doi.org/10.1182/blood.v112.11.325.325.

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Abstract Introduction: Previous phase II studies have suggested that a combination of FCR may increase the outcome of both untreated and relapsed CLL pts. In order to validate this concept the German CLL study group (GCLLSG) initiated a multicentre, multinational phase III trial, CLL8, to evaluate the efficacy and tolerability of FCR versus FC for the first-line treatment of pts with advanced CLL. Methods and Patients: 817 pts with good physical fitness as defined by a cumulative illness rating scale (CIRS) score (Extermann et al., JCO 1998) of up to 6 and a creatinine clearance (cr cl) □d 70

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Katsuya, Yuki, Kan Yonemori, Toshio Shimizu, et al. "Abstract CT062: A phase 1 study of tamnorzatinib (ONO-7475), an Axl/Mer dual inhibitor, alone and in combination with nivolumab in patients with advanced or metastatic solid tumors." Cancer Research 84, no. 7_Supplement (2024): CT062. http://dx.doi.org/10.1158/1538-7445.am2024-ct062.

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Abstract Background: Tamnorzatinib (ONO-7475) is an orally active small molecule Axl/Mer dual inhibitor that not only directly acts on cancer cells to suppress their proliferation, but also on immune cells and exerts characteristics of cancer immunotherapy. Methods: We performed a phase 1 study to assess the tolerability, safety, and pharmacokinetics of ONO-7475 alone (Part A) and in combination with nivolumab (NIVO) (Part B) in Japanese patients (pts) with advanced or metastatic solid tumors (NCT03730337). Patients received once-daily ONO-7475 (3-10 mg, orally) as a monotherapy or in combinat

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Cox, Gregory R., Ben Desbrow, Paul G. Montgomery, et al. "Effect of different protocols of caffeine intake on metabolism and endurance performance." Journal of Applied Physiology 93, no. 3 (2002): 990–99. http://dx.doi.org/10.1152/japplphysiol.00249.2002.

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Competitive athletes completed two studies of 2-h steady-state (SS) cycling at 70% peak O2uptake followed by 7 kJ/kg time trial (TT) with carbohydrate (CHO) intake before (2 g/kg) and during (6% CHO drink) exercise. In Study A, 12 subjects received either 6 mg/kg caffeine 1 h preexercise (Precaf), 6 × 1 mg/kg caffeine every 20 min throughout SS (Durcaf), 2 × 5 ml/kg Coca-Cola between 100 and 120 min SS and during TT (Coke), or placebo. Improvements in TT were as follows: Precaf, 3.4% (0.2–6.5%, 95% confidence interval); Durcaf, 3.1% (−0.1–6.5%); and Coke, 3.1% (−0.2–6.2%). In Study B, eight su

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Fiegl, Michael, Andreas Falkner, Michael Fidrik, et al. "Alemtuzumab in B-Cell Prolymphoytic Leukemia (B-PLL) and Richter’s Transformation." Blood 108, no. 11 (2006): 4733. http://dx.doi.org/10.1182/blood.v108.11.4733.4733.

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Abstract Alemtuzumab is the standard therapy for treatment of patients with relapsed/refractory B-CLL. Significant responses have also been documented in the front-line CLL setting, and as well as in first-line therapy of patients with T-PLL, a population with an exceptionally poor prognosis and few available therapeutic options. Limited data available on the therapeutic benefit of alemtuzumab in other aggressive lymphomas such as B-PLL, which is rare, with a heterogeneous clinical course, and often chemoresistant, as well as CLL with Richter’s transformation, which is also characterized by a

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Shao, Yu Yun, Chi-Huang Hsiao, Ray Lee, et al. "Tumor c-Met expression and prognosis of advanced hepatocellular carcinoma patients treated with sorafenib." Journal of Clinical Oncology 33, no. 3_suppl (2015): 317. http://dx.doi.org/10.1200/jco.2015.33.3_suppl.317.

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317 Background: Overexpression of c-Met signaling has been associated with development and progression of hepatocellular carcinoma (HCC). We explored the prognostic role of tumor c-Met expression in patients with advanced HCC. Methods: Patients who had received sorafenib alone as first-line therapy for advanced HCC and had available archival tumor tissues were enrolled. Expression of total c-Met was determined by immunohistochemical staining using CONFIRM anti-total c-MET (SP44) rabbit monoclonal primary antibody (Ventana) on the BenchMark ULTRA staining platform. We evaluated c-Met expression

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Pawlak, Zenon, and Michal Sojka. "The amphoteric cartilage surface tested in the pH Range from 2.0 to 9.0." Journal of Clinical Case Reports and Studies 3, no. 1 (2022): 01–04. http://dx.doi.org/10.31579/2690-8808/092.

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Background: Phospholipids adsorbed to negatively-charged proteoglycan matrix form phospholipid (membrane), have negatively charged surface (-PO4-) and are hydrophilic. Strong adsorption and strong cohesion are necessary for phospholipids to provide a good lubricant. The surface energy of spherical lipid bilayers have "bell-curve" shaped has amphoteric character and lowest surface energy at a pH 7.4 ± 1 of the natural joint. Objectives: The amphoteric character of the natural surface of the articular cartilage was determined by measuring the surface energy of the model spherical bilayer lipid m

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Cassone, Antonio. "Immunogenic and immunomodulatory properties of mannoproteins from Candida albicans." Canadian Journal of Botany 73, S1 (1995): 1192–98. http://dx.doi.org/10.1139/b95-378.

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Candida albicans is a human commensal and opportunistic fungal organism that expresses on its surface and releases into the external milieu a variety of mannoprotein molecules that are relevant in many aspects of host–Candida relationship. We have attempted to relate mannoprotein constituents to the microbial function and (or) host response. For instance, we have recently found that a protein moiety of a 65-kDa mannoprotein is a major target of cell-mediated immune response. The pattern of cytokines produced by mannoprotein-stimulated human mononuclear cell cultures and mannoprotein-specific T

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Bazié, Bazoin Sylvain Raoul, Adjima Bougma, Aminata Séré, et al. "Assessment of heterocyclic aromatic amines contents in flamed and braised chicken in Burkina Faso." PLOS ONE 17, no. 12 (2022): e0278712. http://dx.doi.org/10.1371/journal.pone.0278712.

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The nutritional status of meat is tarnished by its association with the induced cooking contaminants. The aim of this study was to assess the heterocyclic aromatic amines profile and contents in processed chicken in Burkina Faso. Eight polar and apolar heterocyclic aromatic amines (HAAs) including 2-mino-3-methylimidazo[4,5-f]quinolone (IQ), 3-amino-1,4-dimethyl-5H-pyrido[4, 3-b]indole (Trp-P1), 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P2), 2-mino-9H-pyrido-[2,3-b]indole (AαC), 2-amino-1-methyl-6-phenylimidazo[4, 5– ]pyridine (PhIP), 2-amino-3-methyl-9H-pyrido[2,3-b] indole (MeAαC), 2-amin

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Zhuo, Lang, S. L. Sajdak, and R. B. Phillips. "Minimal intraspecific variation in the sequence of the transcribed spacer regions of the ribosomal DNA of lake trout (Salvelinus namaycush)." Genome 37, no. 4 (1994): 664–71. http://dx.doi.org/10.1139/g94-094.

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Intraspecific variation in the sequence of the transcribed spacer regions of the ribosomal DNA (rDNA) in lake trout was examined by restriction mapping and sequencing of these regions amplified by the polymerase chain reaction. The length of the first internal transcribed spacer region (ITS-1) was 566 bases and the second internal transcribed spacer region (ITS-2) was 368 bases in lake trout. When the 1.4-kb region including the ITS-1, the 5.8S coding region, and the ITS-2 was amplified from 12 individuals from four populations and digested with eight different enzymes only one intraindividual

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Harrowfield, Jack M., Raj Pal Sharma, Brian W. Skelton, and Allan H. White. "Structural Systematics of 2/4-Nitrophenoxide Complexes of Closed-Shell Metal Ions. IV [Acid Salts] of the 4-Nitrophenoxides of Group 1." Australian Journal of Chemistry 51, no. 8 (1998): 747. http://dx.doi.org/10.1071/c97101.

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Room-temperature single-crystal X-ray studies are recorded for a number of ‘acid salts’ formed between Group 1 salts of 4-nitrophenol, M(4-np), and the parent ligand 4-npH, variously hydrated. The 1 : 1 salts M(4-np)(4-npH).x H2O are found for all of M = Li, Na, K, Rb and Cs. The lithium adduct (tetrahydrate) is monoclinic, C2/c, a 19·438(4), b 11·207(2), c 7·421(2) Å, β 91·38(2)°, Z = 4, conventional R on |F| being 0·043 for 1369 independent ‘observed’ (I > 3σ(I)) diffractometer reflections. The sodium adduct (dihydrate) is monoclinic, C2, a 2·174(3), b 3·674(2), c 10·358(1) Å, β 117·21(1)

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Peslin, R., C. Duvivier, H. Bekkari, E. Reichart, and C. Gallina. "Stress adaptation and low-frequency impedance of rat lungs." Journal of Applied Physiology 69, no. 3 (1990): 1080–86. http://dx.doi.org/10.1152/jappl.1990.69.3.1080.

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At transpulmonary pressures (Ptp) of 7-12 cmH2O, pressure-volume hysteresis of isolated cat lungs has been found to be 20-50% larger than predicted from their amount of stress adaptation (J. Hildebrandt, J. Appl. Physiol. 28: 365-372, 1970). This behavior is inconsistent with linear viscoelasticity and has been interpreted in terms of plastoelasticity. We have reinvestigated this phenomenon in isolated lungs from 12 Wistar rats by measuring 1) the changes in Ptp after 0.5-ml step volume changes (initial Ptp of 5 cmH2O) and 2) their response to sinusoidal pressure forcing from 0.01 to 0.67 Hz (

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Fidias, P., T. A. Ciuleanu, O. Gladkov, et al. "A randomized, open-label, phase III trial of NOV-002 in combination with paclitaxel (P) and carboplatin (C) versus paclitaxel and carboplatin alone for the treatment of advanced non-small cell lung cancer (NSCLC)." Journal of Clinical Oncology 28, no. 18_suppl (2010): LBA7007. http://dx.doi.org/10.1200/jco.2010.28.18_suppl.lba7007.

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LBA7007 Background: NOV-002 is a formulation of disodium glutathione disulfide (GSSG). GSSG is a naturally occurring substance that functions as a component of the glutathione (GSH) pathway, vital to the regulation of the intracellular redox state. A key function of the GSH/GSSG redox couple is to dynamically regulate protein functions, including cell signaling pathways, through the reversible formation of mixed disulfides between protein cysteines and GSH (S-glutathionylation). Based on positive results from a randomized, phase I/II study of carboplatin and paclitaxel (CP) with or without NOV

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Rusconi, Chiara, Maria Luisa Guerrera, Alessandra Tedeschi, et al. "Outcome of Transformed Marginal Zone Lymphomas Treated in the Rituximab Era." Blood 126, no. 23 (2015): 5098. http://dx.doi.org/10.1182/blood.v126.23.5098.5098.

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Abstract Introduction: Transformation of Marginal Zone Lymphoma (MZL) into an aggressive histology is uncommon phenomenon that can occur at any time after diagnosis and is expected to have a detrimental impact on prognosis. Biological and clinical knowledge on transformed Marginal Zone Lymphoma (tMZL) is poor and no standard treatment is established in the Rituximab era for these patients (pts). We retrospectively analyzed all consecutive biopsy proven tMZL in two Italian Hematological Divisions from 2002 to 2014 and we focused on post-transformation treatment and outcome. Methods: The dataset

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Vose, Julie M., Shelly Carter, Linda J. Burns, et al. "Phase III Randomized Study of Rituximab/Carmustine, Etoposide, Cytarabine, and Melphalan (BEAM) Compared With Iodine-131 Tositumomab/BEAM With Autologous Hematopoietic Cell Transplantation for Relapsed Diffuse Large B-Cell Lymphoma: Results From the BMT CTN 0401 Trial." Journal of Clinical Oncology 31, no. 13 (2013): 1662–68. http://dx.doi.org/10.1200/jco.2012.45.9453.

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PurposeThis clinical trial evaluated standard-dose radioimmunotherapy with a chemotherapy-based transplantation regimen followed by autologous hematopoietic cell transplantation versus rituximab with the same regimen in patients with relapsed diffuse large B-cell lymphoma (DLBCL).Patients and MethodsPatients with chemotherapy-sensitive persistent or relapsed DLBCL were randomly assigned to receive iodine-131 tositumomab (dosimetric dose of 5 mCi on day −19 and therapeutic dose of 0.75 Gy on day −12), carmustine 300 mg/m2(day −6), etoposide 100 mg/m2twice daily (days −5 to −2), cytarabine 100 m

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Fernández, M., M. L. Ruiz, C. Linares, A. Fominaya, and M. Pérez de la Vega. "5S rDNA genome regions of Lens species." Genome 48, no. 5 (2005): 937–42. http://dx.doi.org/10.1139/g05-052.

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The length variability of the nontranscribed spacer (NTS) of the 5S rDNA repeats was analyzed in species of the genus Lens by means of PCR amplification. The NTS ranged from ~227 to ~952 bp. The polymorphism detected was higher than previous NTS polymorphisms described in this genus. Three NTS length variants from Lens culinaris subsp. culinaris and 2 from Lens culinaris subsp. orientalis were sequenced. The culinaris NTS fragment lengths were 239, 371, and 838 bp, whereas the orientalis ones were 472 bp and 506 bp, respectively. As a result of sequence similarities, 2 families of sequences we

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Ma, Fei, Lixi Li, Zongbi Yi, et al. "The prevalence of BRCA1/2 germline mutation in Chinese pan-cancer." Journal of Clinical Oncology 38, no. 15_suppl (2020): e13684-e13684. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e13684.

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e13684 Background: Pathogenic variants in cancer predisposition genes BRCA1/2 confer susceptibility to breast and ovarian cancer and well-studied. But the characteristics of BRCA in other cancers is unknown, we identified and characterized BRCA germline variants in a large pan-cancer in China. Methods: NGS was performed on genomic DNA from 29,676 pan-cancer patients. Large fragment deletions were all verified by QPCR. We integrated guidelines of ACMG/AMP, ENIGMA and China expert consensus. Based on the in-house system, variants were interpreted one-by-one and classified into 5 grades: Benign (

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de Oliveira, Rosilane Gomes de Souza, Arley Faria José de Oliveira, and Marle Angélica Villacorta Correa. "Sperm abnormalities in matrinxã Brycon amazonicus after hormonal treatment with carp pituitary extract and Ovaprim™." Zygote 26, no. 4 (2018): 279–85. http://dx.doi.org/10.1017/s0967199418000199.

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SummaryThe aim of this study was to evaluate if hormonal treatment causes changes in the morphology of matrinxã Brycon amazonicus spermatozoa. Twelve males were randomized into three treatment groups: 1, Ovaprim™ (0.5 ml/kg); 2, carp pituitary extract (CPE; 2.0 mg/kg); and 3, NaCl solution 0.9% – control group (0.5 ml/kg); with four replicates. Morphological sperm analysis was performed using an optical and scanning electron microscope. The percentage of normal spermatozoa (49.6±4.6% to 60.8±2.8%), with primary (26.1±6.4% to 45.3±4.5%) and secondary abnormalities (4.4±2.9% to 13.9±3.5%) did no

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Winkler, U., M. Jensen, O. Manzke, H. Schulz, V. Diehl, and A. Engert. "Cytokine-Release Syndrome in Patients With B-Cell Chronic Lymphocytic Leukemia and High Lymphocyte Counts After Treatment With an Anti-CD20 Monoclonal Antibody (Rituximab, IDEC-C2B8)." Blood 94, no. 7 (1999): 2217–24. http://dx.doi.org/10.1182/blood.v94.7.2217.419k02_2217_2224.

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Eleven patients with relapsed fludarabine-resistant B-cell chronic lymphocytic leukemia (CLL) or leukemic variants of low-grade B-cell non-Hodgkin’s lymphoma (NHL) were treated with the chimeric monoclonal anti-CD20 antibody rituximab (IDEC-C2B8). Peripheral lymphocyte counts at baseline varied from 0.2 to 294.3 × 109/L. During the first rituximab infusion, patients with lymphocyte counts exceeding 50.0 × 109/L experienced a severe cytokine-release syndrome. Ninety minutes after onset of the infusion, serum levels of tumor necrosis factor- (TNF-) and interleukin-6 (IL-6) peaked in all patien

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