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Littérature scientifique sur le sujet « Adenine nucleotides Receptors »

Auteur : Grafiati

Publié le 4 juin 2021

Mis à jour le 10 février 2022

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Articles de revues sur le sujet "Adenine nucleotides Receptors"

Stone, Trevor W. "Receptors for adenosine and adenine nucleotides." General Pharmacology: The Vascular System 22, no. 1 (January 1991): 25–31. http://dx.doi.org/10.1016/0306-3623(91)90305-p.

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Newman, George C., Frank E. Hospod, Sean D. Trowbridge, Shilpa Motwani, and Yan Liu. "Restoring Adenine Nucleotides in a Brain Slice Model of Cerebral Reperfusion." Journal of Cerebral Blood Flow & Metabolism 18, no. 6 (June 1998): 675–85. http://dx.doi.org/10.1097/00004647-199806000-00010.

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Tissue adenine nucleotides are depleted during cerebral ischemia, impeding recovery after reperfusion. Although prior studies have attempted to prevent the initial loss of adenylates, the present study tests the hypothesis that stimulating synthesis of adenine nucleotides, through either adenosine kinase or adenine phosphoribosyltransferase, would result in significant cerebroprotection. To study the effects on neurons and glia directly while avoiding the influence of the cerebral vasculature, hippocampal brain slices were used for the model of transient ischemia with reperfusion. The standard

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Gorman, Mark W., Kayoko Ogimoto, Margaret V. Savage, Kenneth A. Jacobson, and Eric O. Feigl. "Nucleotide coronary vasodilation in guinea pig hearts." American Journal of Physiology-Heart and Circulatory Physiology 285, no. 3 (September 2003): H1040—H1047. http://dx.doi.org/10.1152/ajpheart.00981.2002.

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The role of P1 receptors and P2Y1 receptors in coronary vasodilator responses to adenine nucleotides was examined in the isolated guinea pig heart. Bolus arterial injections of nucleotides were made in hearts perfused at constant pressure. Peak increase in flow was measured before and after addition of purinoceptor antagonists. Both the P1 receptor antagonist 8-( p-sulfophenyl)theophylline and adenosine deaminase inhibited adenosine vasodilation. AMP-induced vasodilation was inhibited by P1 receptor blockade but not by adenosine deaminase or by the selective P2Y1 antagonist N6-methyl-2′-deoxya

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Murugappan, Swaminathan, Haripriya Shankar, and Satya P. Kunapuli. "Platelet Receptors for Adenine Nucleotides and Thromboxane A2." Seminars in Thrombosis and Hemostasis 30, no. 4 (August 2004): 411–18. http://dx.doi.org/10.1055/s-2004-833476.

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Eltzschig, Holger K., Linda F. Thompson, Jorn Karhausen, Richard J. Cotta, Juan C. Ibla, Simon C. Robson, and Sean P. Colgan. "Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism." Blood 104, no. 13 (December 15, 2004): 3986–92. http://dx.doi.org/10.1182/blood-2004-06-2066.

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Abstract Hypoxia is a well-documented inflammatory stimulus and results in tissue polymorphonuclear leukocyte (PMN) accumulation. Likewise, increased tissue adenosine levels are commonly associated with hypoxia, and given the anti-inflammatory properties of adenosine, we hypothesized that adenosine production via adenine nucleotide metabolism at the vascular surface triggers an endogenous anti-inflammatory response during hypoxia. Initial in vitro studies indicated that endogenously generated adenosine, through activation of PMN adenosine A2A and A2B receptors, functions as an antiadhesive sig

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Williams, Wynford R. "Dampening of neurotransmitter action: molecular similarity within the melatonin structure." Endocrine Regulations 52, no. 4 (October 1, 2018): 199–207. http://dx.doi.org/10.2478/enr-2018-0025.

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AbstractObjectives. Melatonin initiates physiologic and therapeutic responses in various tissues through binding to poorly defined MT receptors regulated by G-proteins and purine nucleotides. Melatonin’s interaction with other G-protein regulated receptors, including those of serotonin, is unclear. This study explores the potential for the interaction of melatonin with nucleotide and receptor ligand structures. Methods. The study uses a computational program to investigate relative molecular similarity by the comparative superimposition and quantitative fitting of molecular structures to adeni

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Antos, Laura K., and Lincoln R. Potter. "Adenine nucleotides decrease the apparentKmof endogenous natriuretic peptide receptors for GTP." American Journal of Physiology-Endocrinology and Metabolism 293, no. 6 (December 2007): E1756—E1763. http://dx.doi.org/10.1152/ajpendo.00321.2007.

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Natriuretic peptide receptors A (NPR-A) and B (NPR-B) mediate most effects of natriuretic peptides by synthesizing cGMP. ATP increases the activity of these receptors by an unknown mechanism. We recently reported that a nonhydrolyzable form of ATP, adenylyl imidodiphosphate (AMPPNP), stabilizes but is not required for the activation of NPR-A and NPR-B in membranes from highly overexpressing cells. Here, we repeated these studies on receptors expressed in endogenous settings. Kinetic analysis indicated that both AMPPNP and ATP dramatically decrease the apparent Kmof both receptors for GTP but h

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Kawa, Kazuyoshi. "Discrete but simultaneous release of adenine nucleotides and serotonin from mouse megakaryocytes as detected with patch- and carbon-fiber electrodes." American Journal of Physiology-Cell Physiology 286, no. 1 (January 2004): C119—C128. http://dx.doi.org/10.1152/ajpcell.00014.2003.

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Using patch- and carbon-fiber electrodes, we studied release phenomena of adenine nucleotides and serotonin from megakaryocytes isolated from the bone marrow of the mouse. Megakaryocytes express ionotropic purinergic receptors on their surfaces. Under the condition of whole cell recording, the cells showed spikelike spontaneous inward currents. The spontaneous currents were carried by cations and had amplitudes of 30–800 pA at –43 mV and durations of 0.1–0.3 s. Pyridoxalphosphate-6-azophenyl-2′,4′-disulfonic acid (PPADS; 100 μM) and suramin (100 μM), purinoceptor-blocking agents, depressed the

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Puchałowicz, Kamila, Maciej Tarnowski, Marta Tkacz, Dariusz Chlubek, Patrycja Kłos, and Violetta Dziedziejko. "Extracellular Adenine Nucleotides and Adenosine Modulate the Growth and Survival of THP-1 Leukemia Cells." International Journal of Molecular Sciences 21, no. 12 (June 22, 2020): 4425. http://dx.doi.org/10.3390/ijms21124425.

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A new approach to improve the effectiveness of acute myeloid leukemia (AML) treatment is to use the properties of purinergic signaling molecules secreted into the bone marrow milieu in response to leukemic cell growth. Therefore, our study aimed to evaluate the effects of extracellular adenine nucleotides and adenosine on the growth and death parameters in the leukemic THP-1 cell line. Cells were exposed to ATP, ADP, AMP, adenosine and nonhydrolyzable analogues of ATP and ADP (ATPγS and ADPβS) in a 1–1000 μM broad concentration range. The basal mRNA expression of the P1 and P2 receptors was ev

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Cattaneo, M. "The platelet P2 receptors in inflammation." Hämostaseologie 35, no. 03 (2015): 262–66. http://dx.doi.org/10.5482/hamo-14-09-0044.

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SummaryIn addition to their well characterized and established role in haemostasis and thrombosis, platelets contribute to the pathogenesis of inflammation. Adenine nucleotides are signalling molecules that regulate the function of virtually every cell in the body, by interacting with P2 receptors. Their important role in inflammation is well established. In the last few years, the pro-inflammatory roles of adenine nucleotides interacting with their platelet P2 receptors has emerged. In particular, it was shown that the platelet P2Y12 receptor for ADP significantly contributed to the proinflam

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Thèses sur le sujet "Adenine nucleotides Receptors"

Crisp, Michael G. "Organoplatinum(II) complexes with hydrogen-bonding functionality and their potential use as molecular receptors for adenine : a thesis submitted for the degree of Master of Science." Title page, abstract and contents only, 2002. http://web4.library.adelaide.edu.au/theses/09SM/09smc932.pdf.

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Errata pasted onto front end-paper. Includes bibliographical references (leaves 82-86). Describes the preparation and characterisation of a novel series of organoplatinum(II) complexes with hydrogen-bonding functionality.

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Gaboardi, Angela Kampfer. "Regulation of the cardiac isoform of the ryanodine receptor by S-adenosyl-l-methionine." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/42854.

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Activity of the Ryanodine Receptor (RyR2) (aka cardiac Ca2+ release channel) plays a pivotal role in contraction of the heart. S-adenosyl-l-methionine (SAM) is a biological methyl group donor that has close structural similarity to ATP, an important physiological regulator of RyR2. This work provides evidence that SAM can act as a RyR2 regulatory ligand in a manner independent from its recognized role as a biological methyl group donor. RyR2 activation appears to arise from the direct interaction of SAM, via its adenosyl moiety, with the RyR2 adenine nucleotide binding sites. Because uncerta

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Chan, Wei Mun. "Adenine nucleotide activation of the cardiac ryanodine receptor." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.396214.

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Landon, Linda A. Neighbors. "Salivary gland P2 nucleotide receptors : structure and function studies /." free to MU campus, to others for purchase, 1998. http://wwwlib.umi.com/cr/mo/fullcit?p9904855.

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Kong, Qiongman. "Regulations and functions of P2Y₂ and P2X₇ nucleotide receptors in the central nervous system." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/4847.

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Thesis (Ph.D.)--University of Missouri-Columbia, 2007.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on March 19, 2009) Vita. Includes bibliographical references.

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Tikh, Eugene I. "Regulation of Contractility by Adenosine A₁ and A_2A Receptors in the Murine Heart: Role of Protein Phosphatase 2A: A Dissertation." eScholarship@UMMS, 2006. https://escholarship.umassmed.edu/gsbs_diss/130.

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Adenosine is a nucleoside that plays an important role in the regulation of contractility in the heart. Adenosine receptors are G-protein coupled and those implicated in regulation of contractility are presumed to act via modulating the activity of adenylyl cyclase and cAMP content of cardiomyocytes. Adenosine A1 receptors (A1R) reduce the contractile response of the myocardium to β-adrenergic stimulation. This is known as anti adrenergic action. The A2A adenosine receptor (A2AR) has the opposite effect of increasing contractile responsiveness of the myocardium. The A2AR also appears to attenu

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Pursell, Natalie W. "Hsp90-Mediated Maturation of Kinases and Nuclear Steroid Hormone Receptors: A Dissertation." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/535.

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Among heat shock proteins, Hsp90 is unusual because it is not required for the proper folding of most cellular proteins but rather is disproportionally linked to the activation of signal transduction proteins including over forty kinases and many steroid hormone receptors. Mutated forms of many Hsp90 clients are causative agents in cancer, making Hsp90 a promising pharmacological target. Many small molecular inhibitors have been identified that competitively bind to the ATP binding site of Hsp90, some of which are in clinical trials as anticancer agents. Although the activation of kinase and h

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Feliu, Catherine. "Implication des récepteurs P1 et P2 dans la protection des cellules endothéliales au cours de l’hypoxie-reoxygenation Complementary Role of P2 and adenosine receptors in ATP induced-anti-apoptotic effects against hypoxic injury of HUVECs Current knowledge on the role of P2Y receptors in cardioprotection against ischemia-reperfusion Intra-extracellular quantification of nucleotides and adenosine using UHPLCHRMS: improvement of robustness by the use of ascorbic acid in mobile phase Description of the novel cytoprotective action pathways of ticagrelor against hypoxic lesions at the endothelium." Thesis, Reims, 2019. http://www.theses.fr/2019REIMM202.

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Au cours de l’ischémie cardiaque, la lésion est initiée au niveau de l’endothélium, et progresse aux cardiomyocytes environnants. La signalisation purinergique joue un rôle important au cours d’épisodes l’ischémie/reperfusion (I/R). De multiples travaux ont portés sur l’étude des mécanismes de protection des nucléotides et nucléosides, sans pour autant étudier leurs rôles spécifiques sur l’endothélium. Dans ce travail, nous mettons en évidence une augmentation des concentrations extracellulaires en ATP et adénosine provenant de l’endothélium soumis à une hypoxie. Au niveau endothélial, nous me

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Pereira, Maria Margarida Ribeirinho. "The role of hypoxia driven adenosinergic pathway in the malignant features of bladder cancer cells." Master's thesis, 2020. http://hdl.handle.net/10316/93875.

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Dissertação de Mestrado em Bioquímica apresentada à Faculdade de Ciências e Tecnologia<br>Introdução: A hipóxia é uma característica comum dos tumores sólidos e desempenha um papel crítico nas neoplasias malignas, incluindo o cancro da bexiga (CB). O factor induzível por hipóxia-1α (HIF-1α) desempenha um papel importante na regulação da resposta das células tumorais sujeitas ao stress hipóxico que resulta em alterações metabólicas e na ativação de mecanismos de sobrevivência. As células hipóxicas sobreexpressam as ecto-nucleotidases CD39 e CD73 que estão envolvidas na geração de adenosina extr

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Silva, Tiago Soares. "Interaction between ecto-5’-nucleotidase and adenosine A2A receptors in nerve terminals of mice prefrontal cortex." Master's thesis, 2013. http://hdl.handle.net/10316/24725.

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Dissertação de mestrado em Bioquímica, apresentada ao Departamento Ciências da Vida da Faculdade de Ciências e Tecnologia da Universidade de Coimbra.<br>A ativação dos recetores de adenosina A2A (A2AR) é feita através da adenosina que pode ser produzida através do catabolismo do ATP libertado no meio extracelular. A ecto-5’-nucleotidase (e-5’N) desempenha um papel importante na formação de adenosina proveniente do catabolismo do ATP, e subsequentemente na ativação dos A2AR controlando assim a plasticidade sináptica. Após uma lesão cerebral, o ATP é libertado como um sinal aversivo provocando o

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Livres sur le sujet "Adenine nucleotides Receptors"

Pharmacology of purine and pyrimidine receptors. San Diego, CA: Elsevier, 2011.

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1931-, Imai Shōichi, Nakazawa Mikio, and International Symposium on Adenosine and Adenine Nucleotides (4th : 1990 : Yamanaka Lake, Japan), eds. Role of adenosine and adenine nucleotides in the biological system: Metabolism, release, transport, receptors, transduction mechanisms and biological actions : proceedings of the 4th international symposium on adenosine and adenine nucleotides, Lake Yamanaka, Japan, 13-17 May, 1990. Amsterdam: Elsevier, 1991.

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1953-, Jacobson Kenneth Alan, and Jarvis Michael F, eds. Purinergic approaches in experimental therapeutics. New York: Wiley-Liss, 1997.

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Imai, Shoichi. Role of Adenosine and Adenine Nucleotides in the Biological System: Metabolism, Release, Transport, Receptors, Transduction Mechanisms and Biologica. Elsevier Science Ltd, 1991.

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W, Stone T., ed. Adenosine in the nervous system. London: Academic Press, 1991.

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1953-, Jacobson Kenneth Alan, Daly John W, and Manganiello V, eds. Purines in cellular signaling: Targets for new drugs. New York: Springer-Verlag, 1990.

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Daly, John W., and Kenneth A. Jacobson. Purines in Cellular Signaling: Targets for New Drugs. Springer, 1990.

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Jacobson, Kenneth A. Purines in Cellular Signaling: Targets for New Drugs. Springer, 2011.

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Chapitres de livres sur le sujet "Adenine nucleotides Receptors"

Illes, P., K. Nieber, and W. Nörenberg. "Neuronal ATP Receptors." In Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology, 77–84. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-2011-5_10.

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Kollias-Baker, Cynthia, John C. Shryock, and Luiz Belardinelli. "Myocardial Adenosine Receptors." In Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology, 221–28. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-2011-5_26.

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Jacobson, Marlene A. "Molecular Biology of Adenosine Receptors." In Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology, 5–13. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-2011-5_1.

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Hoppe, Edmund, and Martin J. Lohse. "Desensitization of A1 Adenosine Receptors." In Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology, 133–38. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-2011-5_16.

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Burnstock, Geoffrey, and Noel J. Buckley. "The Classification of Receptors for Adenosine and Adenine Nucleotides." In Methods Used in Adenosine Research, 193–212. Boston, MA: Springer US, 1985. http://dx.doi.org/10.1007/978-1-4684-4886-3_11.

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Mustafa, S. Jamal, Ravi Marala, Worku Abebe, Neil Jeansonne, Hammed Olanrewaju, and Tahir Hussain. "Coronary Adenosine Receptors: Subtypes, Localization, and Function." In Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology, 229–39. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-2011-5_27.

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Burnstock, Geoffrey. "Receptors for ATP at Peripheral Neuroeffector Junctions." In Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology, 289–95. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-2011-5_33.

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Vanderhaeghen, Jean-Jacques, and Serge N. Schiffmann. "In Situ Hybridization of Adenosine Receptors in Brain." In Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology, 21–26. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-2011-5_3.

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IJzerman, Ad P., Nora M. van der Wenden, Philip J. M. van Galen, and Ken A. Jacobson. "Molecular Modeling of Adenosine A1 and A2a Receptors." In Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology, 27–37. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-2011-5_4.

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Song, Yejia, John Shryock, and Luiz Belardinelli. "Modulation of Cardiomyocyte Membrane Currents by A1 Adenosine Receptors." In Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology, 97–102. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-2011-5_12.

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Actes de conférences sur le sujet "Adenine nucleotides Receptors"

Gordon, J. L. "ADENINE NUCLEOTIDES AND THEREGULATION OF VASCULAR TONE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643719.

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ATP, although known mainly as an intracellular energy source, is also capable of acting extracellularly as a vasoactive agent of great potency, at concentrations around lμM or less. ADP is approximately equipotent with ATP in its actions on extracellular receptors in the vasculature.ATP and ADP can arise extracellularly through release from the cytoplasm of cellsexposed to damaging stimuli or by degranulation of platelets. The concentration of the nucleotides in the cytoplasm of most cells (including vascular endothelial and smooth muscle cells) is more than ImM, and the concentration in the d

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Vanhoutte, Paul M. "PLATELETS, ENDOTHELIUM AND VASOSPASM." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643722.

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The endothelium can secrete both relaxing and contracting substances. One of the most powerful stimuli to the release of the former are thrombin and aggregating platelets. This contributes to the protective role of the endothelium against inappropriate intraluminal platelet aggregation and coagulation in blood vessels with an intact intima. Thrombin-induced, endothelium-dependent relaxations have been obtained in isolated arteries of different species, including humans. Endothelium-dependent relaxations can be evoked by autologous platelets in isolated blood vessels of the dog, pig and rat; th

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Gray, S. J., and S. Heptinstall. "INTERACTIONS BETWEEn PGE2 AND INHIBITORS OF PLATELET AGGREGATION THAT ACT THROUGH cAMP." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643582.

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PGE2 has a biphasic effect on platelet aggregation with low concentrations of the prostaglandin potentiating aggregation and high concentrations inhibiting it. In this investigation we have studied the interaction of PGE2 with agents that inhibit platelet aggregation through an effect on cAMP. The agents chosen raise the level of cAMP in platelets by different mechanisms: PGI2, PGD9 and adenosine combine with specific surface-located receptors and stimulate adenylate cyclase (AC) via a guanine nucleotide-binding protein (GNBP), forskolin stimulates AC directly, and AH-P 719 and DN 9693 inhibit

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Jefferson, J. R., J. T. Harmon, and G. A. Jamieson. "ADP-BINDING SITES IN PLATELETS: CHARACTERIZATION BY PHOTOAFFINITY LABELING AND BINDING STUDIES WITH FIXED PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644463.

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Attempts to photoaffinity label platelet ADP receptors with 2-azidoADP have not been successful possibly due to the absence of a spacer arm between the nucleotide and the photolabile group. We have synthesized a probe having a long spacer arm by coupling 2-(3-aminopropylthio)-ADP to succinimidyl 4-3H-azidobenzoate. Labeling competable by ADP could not demonstrated with intact platelets. With isolated platelet membranes, three bands (Mr 140,000, 110,000 and 46,000) were labeled that were not competed by ADP while three other bands (Mr 188,000, 92,000 and 51,000) were competable by 100 uM ADP.An

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