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Littérature scientifique sur le sujet « Agent lysosomotrope »

Auteur : Grafiati

Publié le 4 juin 2021

Mis à jour le 12 février 2022

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Articles de revues sur le sujet "Agent lysosomotrope"

Firestone, Raymond A., Judith M. Pisano, George M. Garrity, Robert A. Fromtling et Sheldon B. Zimmerman. « Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents ». Journal of Medicinal Chemistry 30, n^o 8 (août 1987) : 1519–21. http://dx.doi.org/10.1021/jm00391a043.

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MIR, MUDASIR. « LYSOSOMOTROPIC PROPERTIES OF SODIUM BICARBONATE AND COVID-19 ». FARMACIA 68, n^o 5 (27 octobre 2020) : 771–78. http://dx.doi.org/10.31925/farmacia.2020.5.1.

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SARS-CoV-2 causing COVID-19 has appeared as an ongoing global public crisis, growing with geometric progression and has caused huge devastation till date majorly because of lack of targeted therapeutic agents like vaccines. SARS-Cov-2 entrance into the host cells is reliant on acidic pH. Thus, in the current clinical emergency there is a pressing need to look forward for adjunct therapies which could counter the acidic pH, so as to restrain the viral entry and its subsequent reproduction in the host cells. Therefore, the current review attempted to explore the possibility to use sodium bicarbonate as an alternative lysosomotropic agent based on the reported literature owing to its anti-flu properties and widespread use during 1918 Spanish flu pandemic. The suggestions put forward in the current review article based on the careful use of sodium bicarbonate could probably help to restrain SARS-CoV-2 infection.

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Kalina, M., et R. Socher. « Endocytosis in cultured rat alveolar type II cells : effect of lysosomotropic weak bases on the processes. » Journal of Histochemistry & ; Cytochemistry 39, n^o 10 (octobre 1991) : 1337–48. http://dx.doi.org/10.1177/39.10.1658127.

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We investigated the uptake of Lucifer yellow and surfactant complexed with gold (S-G) by isolated alveolar Type II cells. The fluid phase marker Lucifer yellow did not reach lamellar bodies (LB) even after prolonged incubation time, whereas S-G was internalized and found in LB. Treatment of Type II cells with lysosomotropic weak bases (NH4Cl and chloroquine) resulted in dilation of endosomes, lysosomes, and LB. The effect of these agents on LB resulted in disappearance of their lamellar organization, as detected by polarized light and electron microscopy. After incubation in lysosomotropic agent-free medium, endocytosis of Lucifer yellow and S-G in treated cells was mainly directed towards large vacuoles resembling either multivesicular bodies (MVB) or lysosomes. The possible relationship between LB, MVB, and lysosomes in freshly isolated as well as cultured alveolar Type II cells is discussed.

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Villamil Giraldo, Ana M., Hanna Appelqvist, Thomas Ederth et Karin Öllinger. « Lysosomotropic agents : impact on lysosomal membrane permeabilization and cell death ». Biochemical Society Transactions 42, n^o 5 (18 septembre 2014) : 1460–64. http://dx.doi.org/10.1042/bst20140145.

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Lysosomes are acidic organelles essential for degradation, signalling and cell homoeostasis. In addition, they play a key role in cell death. Permeabilization of the lysosomal membrane and release of hydrolytic enzymes to the cytosol accompanies apoptosis signalling in several systems. The regulatory mechanism of lysosomal stability is, however, poorly understood. Lipophilic or amphiphilic compounds with a basic moiety will become protonated and trapped within lysosomes, and such lysosomotropic behaviour is also found in many pharmacological drugs. The natural sphingolipid sphingosine exhibits lysosomotropic detergent ability and is an endogenous candidate for controlling lysosomal membrane permeabilization. The lysosomotropic properties of certain detergents might be of use in lysosome-targeting anticancer drugs and drug delivery system in the future. The present review summarizes the current knowledge on the targeting and permeabilizing properties of lysosomotropic detergents from a cellular and physicochemical perspective.

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Chen, Grace L., Sarah L. Sutrina, Karen L. Frayer et Winston W. Chen. « Effects of lysosomotropic agents on lipogenesis ». Archives of Biochemistry and Biophysics 245, n^o 1 (février 1986) : 66–75. http://dx.doi.org/10.1016/0003-9861(86)90190-6.

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Xiong, Subin, Hong Li, Bo Yu, Jun Wu et Robert J. Lee. « Triggering Liposomal Drug Release With a Lysosomotropic Agent ». Journal of Pharmaceutical Sciences 99, n^o 12 (décembre 2010) : 5011–18. http://dx.doi.org/10.1002/jps.22210.

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Doi, Syuichi, Kazuyuku Tanabe, Masayasu Watanabe et Masao Yoshimura. « Chloroquine, a lysosomotropic agent, inhibits zygote formation in yeast ». Archives of Microbiology 151, n^o 1 (décembre 1988) : 20–25. http://dx.doi.org/10.1007/bf00444663.

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Liu, Zhenxing, Shuan Zhao, Shuaishuai Wu, Jingyou Zhang, Zunyang Nie et Shenming Zeng. « A novel role of transient receptor potential mucolipin1 (TRPML1) in protecting against imidazole-induced cytotoxicity ». Biochemistry and Cell Biology 92, n^o 4 (août 2014) : 279–86. http://dx.doi.org/10.1139/bcb-2014-0044.

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Lysosomotropic amines cause serious side effects such as cytoplasmic vacuolation and cell death. TRPML1 (also known as mucolipin1), a member of the transient receptor potential (TRP) protein family, may regulate fusion/fission of vesicles along the endocytic pathway and some aspects of lysosomal ion homeostasis. Nevertheless, it is still unknown whether TRPML1 is involved in death of mammalian cells induced by lysosomotropic agents. In this study, imidazole was used as a model to investigate the role of TRPML1 in the cytotoxicity of lysosomotropic agents. Overexpression of wild-type TRPML1 inhibited imidazole-induced vacuole formation and cell death in human endometrial adenocarcinoma (HEC-1B) cells. In contrast, siRNA-mediated TRPML1 knockdown increased the cell death induced by imidazole. Bafilomycin A1 raises the pH of acidic organelles and therefore suppresses accumulation of weak bases in them. Similarly, lysosomal pH was raised in TRPML1-overexpressing cells; therefore, we inferred that TRPML1 protected against imidazole toxicity by regulating the pH of acidic organelles. We concluded that TRPML1 had a novel role in protecting against lysosomotropic amine toxicity.

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SHAMSADEEN, NASRIN, et C. J. DUNCAN. « Action of lysosomotropic agents on mammalian skeletal muscle ». Biochemical Society Transactions 16, n^o 5 (1 octobre 1988) : 786. http://dx.doi.org/10.1042/bst0160786.

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Duncan, R. « Designing polymer conjugates as lysosomotropic nanomedicines ». Biochemical Society Transactions 35, n^o 1 (22 janvier 2007) : 56–60. http://dx.doi.org/10.1042/bst0350056.

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Marriage of cell biology (the concept of ‘lysosomotropic drug delivery’) and the realization that water-soluble synthetic polymers might provide an ideal platform for targeted drug delivery led to the first synthetic polymer–drug conjugates that entered clinical trials as anticancer agents. Conceptually, polymer conjugates share many features with other macromolecular drugs, but they have the added advantage of the versatility of synthetic chemistry that allows tailoring of molecular mass and addition of biomimetic features. Conjugate characteristics must be optimized carefully to ensure that the polymeric carrier is biocompatible and that the polymer molecular mass enables tumour-selective targeting followed by endocytic internalization. The polymer–drug linker must be stable in transit, but be degraded at an optimal rate intracellularly to liberate active drug. Our early studies designed two HPMA [N-(2-hydroxypropyl)methacrylamide] copolymer conjugates containing doxorubicin that became the first synthetic polymer–drug conjugates to be tested in phase I/II clinical trials. Since, a further four HPMA copolymer–anticancer drug conjugates (most recently polymer platinates) and the first polymer-based γ-camera imaging agents followed. Polymer–drug linkers cleaved by lysosomal thiol-dependent proteases and the reduced pH of endosomes and lysosomes have been used widely to facilitate drug liberation. It is becoming clear that inappropriate trafficking and/or malfunction of enzymatic activation can lead to new mechanisms of clinical resistance. Recent studies have described HPMA copolymer conjugates carrying a combination of both endocrine and chemotherapy that are markedly more active than individual conjugates carrying a single drug. Moreover, current research is investigating novel dendritic polymer architectures and novel biodegradable polymers as drug carriers that will provide improved drug delivery and imaging probes in the future. The present paper reviews the clinical status of polymeric anticancer agents, the rationale for the design of polymer therapeutics and discusses the benefits and challenges of lysosomotropic delivery.

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Thèses sur le sujet "Agent lysosomotrope"

Maurin, Max. « Rôle du pH phagolysosomial dans l'action des antibiotiques sur les bactéries intracellulaires ». Paris 7, 1994. http://www.theses.fr/1994PA077067.

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L'absence d'activité d'un antibiotique sur un microorganisme à vie intracellulaire peut correspondre à son incapacité à pénétrer dans la cellule eucaryote, a une localisation subcellulaire différente de celle du microorganisme considéré, ou à une inactivation intracellulaire de l'antibiotique. Nous avons testé l'hypothèse d'une inactivation des antibiotiques dans le milieu phagolysosomial acide, à travers deux modèles de bactéries vivant dans ce compartiment cellulaire ; staphylococcus aureus et coxiella burnetii. Nous avons vérifié dans un premier temps la possibilité d'alcaliniser le ph phagolysosomial par l'utilisation d'agents lysosomotropes. Nous avons ensuite démontré l'effet bactéricide de l'association des agents lysosomotropes aux antibiotiques, alors que ni les agents lysosomotropes ni les antibiotiques n'étaient bactéricides isolement. L'alcalinisation phagolysosomiale est le mécanisme par lequel les agents lysosomotropes ont rétabli l'activité des antibiotiques. Nous avons par ailleurs élaboré un nouveau modèle expérimental d'endocardite à staphylococcus aureus chez le cobaye. Du fait de la méthodologie utilisée, ce modèle est plus proche de l'endocardite sur valve native. Notre but final est de créer un modèle d'endocardite à coxiella burnetii. Ce modèle permettrait notamment de tester in vivo l'activité de l'association des agents lysosomotropes aux antibiotiques.

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Chapitres de livres sur le sujet "Agent lysosomotrope"

Orsi, E. V., S. Joshi, M. Bavlsik, M. Petersheim et Y. Peng. « Effects of Benzene and Other Lysosomotropic Agents on Ultraviolet Light Induced Photolysis of Lysosomes in Herpesvirus Infected Cells ». Dans Environmental Hygiene, 40–43. Berlin, Heidelberg : Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73766-4_10.

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