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Littérature scientifique sur le sujet « Allergia al latte »

Auteur : Grafiati

Publié le 1 avril 2023

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Articles de revues sur le sujet "Allergia al latte"

Longo, Giorgio. « Domande e risposte ». Medico e Bambino 40, n^o 1 (28 janvier 2021) : 59. http://dx.doi.org/10.53126/meb40059.

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Gastaldi, Roberto, Paola Borgia et Mohamad Maghnie. « Lo iodio nell’alimentazione dell’età evolutiva ». L'Endocrinologo 22, n^o 4 (août 2021) : 293–97. http://dx.doi.org/10.1007/s40619-021-00924-2.

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SommarioLo iodio viene assunto esclusivamente attraverso gli alimenti e rappresenta un componente essenziale per la sintesi degli ormoni tiroidei. Una carenza iodica misconosciuta da inadeguato apporto dietetico che si instaura nei primi anni di vita può essere responsabile di scarsa crescita e disordini dello sviluppo neuro-cognitivo. Negli ultimi anni è aumentata la prevalenza delle allergie alimentari e dei cultori di diete vegane nei paesi occidentali. Entrambe le situazioni impongono restrizioni dietetiche, limitando le fonti di importanti nutrienti come iodio, ferro, zinco, vitamina D, calcio e vitamina B12. Nelle allergie alimentari e in regime dietetico vegano, infatti, i primi alimenti ad essere esclusi sono proprio quelli a maggior contenuto di iodio, come pesce, latte, uova e derivati. L’apporto di iodio può dunque divenire insufficiente qualora non ci sia adeguato utilizzo di fonti di iodio alternative, come il sale iodato. Pertanto, risulta fondamentale che gli operatori sanitari siano a conoscenza dei possibili rischi di carenze nutrizionali in bambini con allergia alimentare, vegani o entrambi, al fine di garantire un attento monitoraggio auxologico e nutrizionale e soddisfare il fabbisogno energetico e nutritivo. In questo articolo riassumiamo i principali aspetti riguardanti l’apporto iodico in dieta vegana e nelle diete di esclusione dei bambini con allergie alimentari, revisionando la letteratura su questi argomenti e fornendo alcuni suggerimenti per i pediatri.

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Lariou, Maria Stella, Stavroula Dikalioti, Nick Dessypris, Apostolos Pourtsidis, Margarita Baka, Sophia Polychronopoulou, Fani Athanasiadou Piperopoulou et al. « Country specific serum IgE reactivity profile and concordance with allergic history among acute lymphoblastic leukemia children and controls. » Journal of Clinical Oncology 30, n^o 15_suppl (20 mai 2012) : e20002-e20002. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e20002.

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e20002 Background: Allergy has been studied as a risk factor for several malignancies, including childhood leukemia; yet, the tentative etiological nature of this association needs to be further explored. Published studies suffer inappropriate study design and accuracy of exposure variables. In response to the latter need, this study aims to use country specific biological markers, namely levels of the most prevalent allergen-specific immunoglobulin E (IgE) antibodies in Greece as an alternative exposure measurement to history of allergy and compare their concordance with allergic history. Methods: Allergen-specific-IgEs against 24 most prevalent inhalant and food allergens were determined for 199 incident childhood acute lymphoblastic leukemia (ALL), newly diagnosed cases across Greece and registered in the Nationwide Registry for Childhood Hematological Malignancies (NARECHEM) and 113 hospital controls. K statistic was used to check the concordance between serum IgE specific allergens and allergic history overall, as well as among cases and controls. Results: Concordance between self-reported food allergy and food IgE levels in the same individual among both cases and controls was 87% and 83% for respiratory allergens. Among cases, concordance between self reported food allergies and food IgEs was 92% and 80% for controls (p-value 0.003) and the respective κ statistics were 0.28 for cases and 0.10 for controls. Concordance between self reported respiratory allergies and respiratory IgEs was 84% for cases and 81% for controls (p-value 0.57); κ statistics 0.09 for cases and 0.07 for controls. Conclusions: Much of the discordance among cases and controls (self-report false positives) might probably be a reflection of non allergic food hypersensitivity, an allergy that was surpassed or extended allergen avoidance. Other discordance (self-report false negatives) seems to be the result of food sensitization, either hypoclinical or not acknowledged as a type of allergy by mothers of the children. Nevertheless, these measurements jointly analyzed are valuable in exploring the stated hypothesis, especially in well designed prospective studies.

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KOROGLU, Mustafa, Ibrahim Halil KILIC, Isik Didem KARAGOZ et Mehmet OZASLAN. « Extraction and Purification of the Potential Allergen Proteins from Botryotinia Fuckeliana ». Eurasia Proceedings of Science Technology Engineering and Mathematics 12 (31 décembre 2021) : 28–31. http://dx.doi.org/10.55549/epstem.99247600000.

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An allergy is a disease in which the immune system makes an inflammatory response to a harmless antigen. Any antigen that causes an allergy is called an allergen. Allergens may be inhaled or ingested, or they may come into contact with the skin. According to the data of the World Allergy Organization (WAO), the prevalence of allergies in different countries varies between 10-40%. Pollen, mold, animal hair, house dust mite, medicines, and foods are the most common allergen agents. Common mushrooms in nature have the potential to produce allergenic proteins. Penicillium,Botryotinia, Aspergillus, Rhizopus, and Mucor species, which are allergic fungi, are widely found in nature. In recent years, the cases of allergies caused by molds have increased significantly and studies to determine the causing allergens have accelerated. Botryotinia fuckeliana Pers. is a cosmopolitan necrotrophic pathogen infecting more than 200 plant species in temperate and subtropical climates, some of which are of high economic importance (e.g., grapes, strawberries, solanaceous vegetable). In Europe, maximal spore counts occur during late summer. Prevalence of skin test reactivity, i.e., immediate wheal and flare, to B. cinerea in Europe is comparable to that of Aspergillus spp. and greater than that of Cladosporium and Penicillium spp. Since the prevalence of B. fuckeliana spores and skin test reactivity is significant, further characterization of these allergens is warranted. Botryotinia fuckeliana was used in our study. Botryotinia fuckeliana produced in our laboratory was collected and allergen fungus protein was extracted by 2 different extraction methods. By preparing protein samples from prepared mushroom extracts, the total concentration of potential allergen proteins was determined by the BCA method. According to the data obtained, it was determined that the protein concentration of the mushroom samples dried by that were subjected to dialysis was higher than ethanol.

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Kotowska, Agnieszka. « Assessing of patients’ knowledge of anaphylactic shock and allergies. » Medical Science Pulse 14, SUPPLEMENT 1 (31 décembre 2020) : 1–10. http://dx.doi.org/10.5604/01.3001.0014.6894.

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Background: The World Health Organization (WHO) identified allergy as one of the major problems of the 21st century. It was also stated to be a key issue for health protection and public health care activity in the White Book on Allergy published in 2011. An allergy or atopy is called type I hypersensitivity. It may take the form of immediate (anaphylaxis) or late symptoms including allergic rhinitis and eye diseases, atopic dermatitis, food allergies, anaphylactic shock, allergic asthma and hives. Anaphylaxis and anaphylactic shock can occur at any age. Aim of the study: The goal of the study was to assess patient knowledge about allergies and appropriate actions to take in situations of severe allergic symptoms including anaphylactic shock. Material and methods: The study was conducted in 2018 among 150 adult patients in a clinic of Allergy at Optima Medycyna SA in Opole. The author’s survey questionnaire contained 27 closed single or multiple-choice questions. Results: A satisfactory level of knowledge of the most life-threatening allergy exacerbations was found in 79.3% (119) of the examinees. 53.3% (80) had correct knowledge of how to act in the case of a severe allergic shortness of breath and symptoms that do not subside despite administering medications. In such instances, 46.7% did not know what to do. Only 84.7% (127) of respondents knew the definition of anaphylactic shock while 10% (15) did not know the concept at all. Conclusions: Patients showed a significantly higher level of knowledge about allergy complications than about their causes and prevention. Knowledge about the diagnosis of allergy exacerbations, as well as steps to take in life-threatening situations associated with acute allergic disease and anaphylactic shock in home situations was insufficient. In addition, it was found that nursing staff insufficiently educate patients on allergies and associated complications.

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Rueter, Kristina, Anderson P. Jones, Aris Siafarikas, Ee-Mun Lim, Susan L. Prescott et Debra J. Palmer. « In “High-Risk” Infants with Sufficient Vitamin D Status at Birth, Infant Vitamin D Supplementation Had No Effect on Allergy Outcomes : A Randomized Controlled Trial ». Nutrients 12, n^o 6 (11 juin 2020) : 1747. http://dx.doi.org/10.3390/nu12061747.

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Lower vitamin D status at birth and during infancy has been associated with increased incidence of eczema and food allergies. The aim of this study was to investigate the effect of early infancy vitamin D supplementation on allergic disease outcomes in infants at “hereditary risk” of allergic disease, but who had sufficient vitamin D levels at birth. Here, we report the early childhood follow-up to 2.5 years of age of “high-risk” infants who participated in a double-blinded, randomized controlled trial. For inclusion in this trial, late gestation (36–40 weeks) maternal 25-hydroxyvitamin D levels needed to be ≥50 nmol/L. Infants were randomized to either oral vitamin D supplementation of 400 IU/day (n = 97) or a placebo (n = 98) for the first six months of life. Vitamin D levels and allergic disease outcomes were followed up. There were no statistically significant differences in incidence of any medically diagnosed allergic disease outcomes or allergen sensitization rates between the vitamin D-supplemented and placebo groups at either 1 year or at 2.5 years of age. In conclusion, for “allergy high-risk” infants who had sufficient vitamin D status at birth, early infancy oral vitamin D supplementation does not appear to reduce the development of early childhood allergic disease.

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Best, Karen P., Tim J. Green, Dian C. Sulistyoningrum, Thomas R. Sullivan, Susanne Aufreiter, Susan L. Prescott, Maria Makrides, Monika Skubisz, Deborah L. O'Connor et Debra J. Palmer. « Maternal Late-Pregnancy Serum Unmetabolized Folic Acid Concentrations Are Not Associated with Infant Allergic Disease : A Prospective Cohort Study ». Journal of Nutrition 151, n^o 6 (13 avril 2021) : 1553–60. http://dx.doi.org/10.1093/jn/nxab040.

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ABSTRACT Background The increase in childhood allergic disease in recent decades has coincided with increased folic acid intakes during pregnancy. Circulating unmetabolized folic acid (UMFA) has been proposed as a biomarker of excessive folic acid intake. Objective We aimed to determine if late-pregnancy serum UMFA and total folate concentrations were associated with allergic disease risk in the offspring at 1 y of age in a population at high risk of allergy. Methods The cohort consisted of 561 mother–infant pairs from Western Australia. To be eligible the infant had to have a first-degree relative (mother, father, or sibling) with a history of medically diagnosed allergic disease. Maternal venous blood was collected between 36 and 40 wk of gestation. Serum UMFA was measured by LC–tandem MS. Serum total folate was determined using a microbiological method with chloramphenicol-resistant Lactobacillus rhamnosus as the test organism, and was collected between 36 and 40 wk of gestation. UMFA concentrations were measured by tandem MS using stable isotope dilution; folate concentrations were determined using the microbiological method with standardized kits. Infant allergic disease outcomes of medically diagnosed eczema, steroid-treated eczema, atopic eczema, IgE-mediated food allergy, allergen sensitization, and medically diagnosed wheeze were assessed at 1 y of age. Results Median (IQR) concentrations for UMFA and serum folate were 1.6 (0.6–4.7) and 53.2 (32.6–74.5) nmol/L, respectively. Of the infants, 34.6% had medically diagnosed eczema, 26.4% allergen sensitization, and 14.9% had an IgE-mediated food allergy. In both adjusted and unadjusted models there was little evidence of association between UMFA or serum folate and any of the infant allergy outcomes. Conclusions In this cohort of children at high risk of allergic disease there was no association between maternal UMFA or serum folate concentrations measured in late pregnancy and allergic disease outcomes at 1 y of age.

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Moroni, L., A. Cariddi, S. Sartorelli, E. Della Torre, T. Germanò, G. A. Ramirez, E. Bozzolo, M. R. Yacoub et L. Dagna. « AB0512 ALLERGIC PROFILE AND ALLERGEN-SPECIFIC IMMUNOTHERAPY IN EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS (EGPA) : A SINGLE CENTER OBSERVATIONAL STUDY ». Annals of the Rheumatic Diseases 79, Suppl 1 (juin 2020) : 1553.1–1554. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1766.

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Background:Eosinophilic granulomatosis with polyangiitis (EGPA), previously known as Churg-Strauss syndrome, is a systemic disease characterized by late onset asthma associated with small- and/or medium-size vessel vasculitis, besides eosinophil-mediated cytotoxic organ damage. About 20-30% of patients with EGPA displays allergic manifestations related with inhalant sensitization, while prevalence of food and drug allergy is unknown in this context. Moreover, some authors in the past hypothesized in favor of a possible role of allergen-specific immunotherapy (ASIT) as a trigger of disease.Objectives:Aim of the present study is to establish the prevalence of each category allergen sensitization and to determine whether atopy or specific immunotherapy could influence clinical expression of the disease.Methods:Our study consisted in a retrospective demographic and clinical data collection regarding EGPA history (including age at diagnosis, organ and tissue involvement, autoantibody profile) and the presence of allergic comorbidities or previous drug hypersensitivity reactions. Patients without either proven allergic reactions or positive tests have been excluded.Results:Fifty-three (53) patients with definitive diagnosis of EGPA have been included in the analysis among which 25 (47.2%) with chronic respiratory allergy or previous acute allergic reaction. Among allergic patients 15 (60%) resulted sensitized towards inhalants and among them 13 (86.7%) displayed multiple sensitization. Drug allergy affected 13 patients (52%), food 4 (16%). Among 15 patients with respiratory allergy, 13 were eligible to allergen-specific immunotherapy (ASIT). Seven (7) subjects underwent ASIT prior EGPA diagnosis with an average time-to-EGPA of 16.2 years. No statistically significant difference was found in terms of sex, age at diagnosis, positivity for or specificity of anti-neutrophil cytoplasm antibodies (ANCA), eosinophil count at onset, pattern of clinical manifestations comparing allergic vs. non-allergic, ASIT vs. non-ASIT, ASIT vs. allergic, ASIT vs. eligible.Conclusion:Among patients with EGPA allergies are highly prevalent, particularly towards inhalants and drugs. In the great majority of patients multiple sensitization profile is found. Atopy doesn’t seem to be associated with specific patterns of disease presentation. The absence of correlation between inhalant ASIT exposure and variation in mode and time of EGPA onset doesn’t support the hypothesis of a its potential role in triggering the disease.References:[1]Berti A et al. Severe/uncontrolled asthma and overall survival in atopic patients with eosinophilic granulomatosis with polyangiitis. Respiratory Medicine 2018; DOI: 10.1016/j.rmed.2018.07.017[2]Cottin V et al. Respiratory manifestations of eosinophilic granulomatosis with polyangiitis (Churg–Strauss). European Respiratory Journal 2016; DOI: 10.1183/13993003.00097-2016Disclosure of Interests:Luca Moroni: None declared, adriana cariddi: None declared, Silvia Sartorelli: None declared, Emanuel Della Torre: None declared, Tommaso Germanò: None declared, Giuseppe Alvise Ramirez: None declared, Enrica Bozzolo: None declared, Mona-Rita Yacoub: None declared, Lorenzo Dagna Grant/research support from: The Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR) received unresctricted research/educational grants from Abbvie, Bristol-Myers Squibb, Celgene, Janssen, Merk Sharp & Dohme, Mundipharma Pharmaceuticals, Novartis, Pfizer, Roche, Sanofi-Genzyme, and SOBI., Consultant of: Prof Lorenzo Dagna received consultation honoraria from Abbvie, Amgen, Biogen, Bristol-Myers Squibb, Celltrion, Novartis, Pfizer, Roche, Sanofi-Genzyme, and SOBI.

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Arcimowicz, Magdalena, et Edyta Krzych-Fałta. « Nasal allergen challenge - an important tool in diagnosis of rhinologic disease ». Polski Przegląd Otorynolaryngologiczny 9, n^o 4 (19 décembre 2020) : 1–5. http://dx.doi.org/10.5604/01.3001.0014.6068.

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The nasal allergen challenge (NAC) is used in the diagnosis of rhinitis. The primary use of NAC is to confirm allergy to a specific inhaled allergen. NAC reproduces the allergic reaction of the nasal mucosa under standardized and controlled conditions that occurs after direct intranasal administration of allergens. As the only used method for assessing the degree of allergy, it mimics the body’s natural response to the sensitizing factor in the early and late stages of an allergic reaction. NAC is used in the diagnosis of chronic, occupational and local rhinitis, as well as in the differential diagnosis of rhinitis and ophthalmic symptoms. Under conditions similar to natural exposure, it determines the relationship between the allergen and symptoms of allergic rhinitis, especially in the case of difficulties in interpreting the results of skin tests and the serum concentration of specific IgE. It is a truly valuable tool in determining the indications for immunotherapy and the selection of allergens for desensitization therapy. It also serves as a method of monitoring the effectiveness of immunotherapy and pharmacotherapy. For scientific purposes, NAC is used to study the mechanisms of an allergic reaction and the influence of various factors on its course. It is considered safe, but requires appropriate instruments and qualified personnel.

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Thèses sur le sujet "Allergia al latte"

Mandelli, M. « ALLERGIA ALLE PROTEINE DEL LATTE VACCINO E IMPIEGO DELLE FORMULE SOSTITUTIVE. IMPATTO SULLA CRESCITA E PROFILO PLASMATICO DELLE PROTEINE ». Doctoral thesis, Università degli Studi di Milano, 2012. http://hdl.handle.net/2434/171117.

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Background: Extensively hydrolyzed formula (eHF) is the first-line therapy in cow’s milk protein allergy. Aims of the study: We studied growth and plasmatic protein profile, depending on the different formula employed. Materials and methods: We selected 40 children with cow’s milk protein allergy. Diagnosis was made by skin prick test and double-blind placebo-controlled food challenge. Children were fed with soya protein-based or hydrolyzed rice protein-based or extensively hydrolyzed casein formula. The sample was analyzed at the 6th (t0) and 12th (t1) months of life: anthropometric parameters, plasmatic levels of total proteins, albumin, prealbumin, and retinol binding protein were collected. Results: The comparison among the groups fed with the different formulas didn’t show a gap of weight z-score, length z-score and BMI z- score at t0 and t1. We found a positive trend of growth in children fed with rice protein-based formula. The plasmatic protein profiles among the three groups weren’t statistically different (p<0,05). The mean of plasmatic level of pre-albumin of the two groups fed with eHF is higher than the one of the group fed with soya protein-based formula, especially rice protein-based formula at t0. Conclusions: Children fed with eHF show a positive trend of weight z-score rise. So hydrolyzed proteins could give a nutritional qualitative benefit. Each formula ensures a good growth, but no one is the best, in spite of a positive trend of eHF, especially the rice-based one.

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Evans, David John. « Inflammatory mechanisms in late asthmatic responses to allergen challenge ». Thesis, Imperial College London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267694.

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Taborda, Barata Luis Manuel. « Allergen-induced late-phase responses in the skin of atopic patients ». Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299252.

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Twentyman, Orion Peter. « Mechanisms of allergen-induced late phase asthmatic responses and increased bronchial responsiveness ». Thesis, University of Southampton, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296053.

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Smith, Lance Malcolm. « An experimental investigation of the cutaneous late phase response in humans ». Thesis, University of Southampton, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295707.

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Hutson, Penelope Ann. « Investigations into the mechanisms of late phase responses in guinea pig airways ». Thesis, University of Southampton, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328461.

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Lavinskienė, Simona. « Peripheral blood neutrophil and eosinophil activity during allergen-induced late-phase airway inflammation in asthma ». Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2015. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20150106_083713-90371.

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There is no doubt that eosinophils and neutrophils are important cells participating in asthma pathogenesis. The most prominent feature reflecting asthma pathogenesis is late-phase airway inflammation, which occurs a few hours after allergen inhalation. The worldwide published studies on asthma show that most attention is paid to individual, not complex, functions of neutrophils and eosinophils in the airways. Moreover, associations between peripheral blood neutrophil and eosinophil activity and infiltration of these cells in the airways during asthma have not been com¬pletely elucidated yet. There are no data about peripheral blood neutrophil and eosinophil activity during allergen-induced late-phase airway inflam¬mation in asthma patients. Therefore, the aim of this study was to evaluate peripheral blood neutrophil and eosinophil functional activity during allergen-induced late-phase airway inflammation in asthma. We found that an inhaled allergen activates peripheral blood neutrophil and eosinophil chemotaxis, phagocytosis, generation of reactive oxygen species and also reduces apoptosis during late-phase airway inflammation in asthma. Furthermore, altered peripheral blood neutrophil and eosinophil functional activity is related with airway neutrophilia and eosinophilia. Our findings provide new evidence about neutrophil and eosinophil functional activity during allergen-induced late-phase airway inflammation in asthma patients.
Mokslininkai neabejoja, jog eozinofilai ir neutrofilai yra vienos svarbiausių ląstelių, dalyvaujančių astmos patogenezėje, kurią labiausiai atspindi vėlyva kvėpavimo takų uždegimo fazė, išsivystanti praėjus kelioms valandoms po alergeno įkvėpimo. Pasaulinėje literatūroje publikuojami darbai, nagrinėja atskirus kvė¬pavimo takų neutrofilų ir eozinofilų aktyvumo pokyčius. Ypač mažai darbų apie periferinio kraujo neutrofilų ir eozinofilų funkcijas bei jų ryšį su šių ląstelių pagausėjimu kvėpavimo takuose, sergant astma. Taip pat nėra tyrimų, vertinančių periferinio kraujo uždegimo ląstelių (neutrofilų ir eozi¬nofilų) funkcijų alergeno sukeltos vėlyvos fazės kvėpavimo takų uždegimo metu. Todėl šio tyrimo tikslas buvo įvertinti periferinio kraujo neutrofilų ir eozinofilų funkcinį aktyvumą alergeno sukeltos vėlyvos fazės kvėpavimo takų uždegimo metu sergant astma. Tyrimo metu nustatėme, kad įkvėptas alergenas aktyvina periferinio kraujo neutrofilų ir eozinofilų funkcijas - chemotaksį, fagocitozę, reaktyvių deguonies formų susidarymą, degranuliaciją bei silpnina apoptozę vėlyvos fazės kvėpavimo takų uždegimo metu. O šių ląstelių aktyvumo pokyčiai yra susiję su kvėpavimo takų neutrofilija ir eozinofilija. Moksliniame darbe pateikiami rezultatai suteikia naujų duomenų apie sergančiųjų alergine astma periferinio kraujo neutrofilų ir eozinofilų funkcinių savybių ypatumus ir parodo jų pokyčius alergeno sukeltos vėlyvos fazes kvėpavimo takų uždegimo metu.

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Sandin, Anna. « Development of allergy, salivary IgA antibodies and gut microbiota in a Swedish birth cohort ». Doctoral thesis, Umeå universitet, Pediatrik, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1627.

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The increasing prevalence of allergic diseases in affluent societies has been associated with changes in microbial exposure early in life and a less diverse gut flora. The objective of this thesis was to assess the development of allergic sensitisation and symptoms during the first four years of life in a non-selected birth cohort in relation to environmental factors, family history, gut microbiota and salivary IgA antibodies. The cohort comprised all 1,228 infants living in a Swedish county who were born over a one-year period. The parents replied to questionnaires, and 817 children (67 %) were skin prick tested both at 1 and 4 years of age. Saliva (n=279), faecal (n=139) and blood (n=253) samples were collected at 1 year of age from children with a positive skin prick test at 1 year and from a sample of children with a negative skin prick test. Faecal samples were also obtained from 53 children at 4 years of age. Dog keeping during infancy was associated with a decreased risk of sensitisation to pollen and late-onset wheezing at age 4, and the reduced odds ratios persisted after adjustment for heredity and avoidance measures, OR 0.3, 95% CI 0.1-0.9 and OR 0.5, 95% CI 0.2-1.0, respectively. In contrast, early dog keeping was associated with an increased risk of earlyonset transient wheezing but only in children with parental asthma (OR 2,8, 95% CI 1.3-6.4). Levels of short chain fatty acids (SCFAs) in faeces were assessed both at 1 and 4 years of age and related to the development of sensitisation and symptoms. The levels of acetic (p<.01) and propionic (p<.01) acids decreased from one to four years of age, whereas valeric acid (p<.001) increased which is in line with a more complex gut microbiota with age. Allergic children, compared with non-allergic children, had lower levels of i-butyric, i-valeric and valeric acid in faeces both at 1 and 4 years of age. Low levels of secretory IgA (SIgA) in saliva were associated with wheezing but only in sensitised children. In children with positive SPT to at least one allergen both at 1 and 4 years of age and in children with circulating IgE antibodies to egg or cat at one year of age, those who developed late-onset wheezing had lower levels of SIgA than those who did not, p=.04 and p=.02 respectively. Of 9 children with levels of SIgA in the upper quartile and persistent sensitisation, none developed wheezing, compared with 10/20 children with lower levels, (p=. 01). Having older siblings, more than three infections during infancy, at least one smoking parent and male gender were all associated with high levels (in the upper quartile) of total IgA and SIgA. The findings in this thesis indicate that the microbial load early in life could affect the development of allergy. A functional assessment of the gut flora demonstrated differences between allergic and non-allergic children both at 1 and 4 years of age. Salivary IgA was associated with infections during infancy, and high levels of secretory IgA protected from symptoms in sensitised children. Finally, dog keeping in infancy may offer protection from allergy, but the mechanism is uncertain.

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Bajoriūnienė, Ieva. « 17-o tipo T limfocitų pagalbininkų vaidmuo sergant alergine astma ». Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20140904_150025-10728.

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Astma yra lėtinė kvėpavimo takų uždegimo liga. Mokslininkai neabejoja, jog 2-o tipo T limfocitai pagalbininkai bei eozinofilinis kvėpavimo takų uždegimas yra astmos patogenezės pagrindas. Tačiau šis mechanizmas ne visuomet gali paaiškinti astmos metu esančio kvėpavimo takų uždegimo bei klinikinių simptomų įvairumą, eigos ypatumus ir net skirtingą atsaką į gydymą. Eksperimentiniai tyrimai su gyvūnais parodė 17-o tipo T limfocitų pagalbininkų (Th17) svarbą alerginės astmos vystymuisi. Todėl šio mokslinio tyrimo tikslas buvo įvertinti Th17 limfocitų vaidmenį sergant alergine astma. Tyrimo metu sergantiesiems alergine astma nustatytas didesnis Th17 limfocitų kiekis periferiniame kraujyje bei didesnė interleukino (IL)-17 koncentracija serume ir indukuotuose skrepliuose, lyginant su sveikais asmenimis. Be to, bronchų provokacija su Dermatophagoides pteronyssinus alergenu sukėlė Th17 limfocitų ir IL-17 kiekio padidėjimą praėjus 7 ir 24 val.po jos, ypatingai ryškų sergantiems alergine astma su ankstyva ir vėlyva bronchų obstrukcija. Atlikto tyrimo rezultatai parodė, kad Dermatophagoides pteronyssinus alergenas sukelia vietinį ir sisteminį Th17 limfocitų imuninį atsaką kuris yra susiję su vėlyvos fazės kvėpavimo takų uždegimu.
Allergic asthma is a chronic inflammatory disease of the airways associated with the response of predominant type 2 helper T lymphocytes to an inhaled allergen. However, differences in inflammation and clinical symptoms of this disease not always can be explained by this mechanism. Recent animal model studies have shown the importance of type 17 helper T lymphocytes (Th17) in the development of allergic asthma. The role of these cells in causing allergen-induced airway inflammation as well as systemic inflammatory response in human is still not well defined. Therefore, we investigated the peripheral blood Th17 lymphocyte response to inhaled Dermatophagoides pteronyssinus (D. pteronyssinu) allergen in patients with allergic asthma. The present study has shown that patients with allergic asthma have a higher percentage of peripheral blood Th17 lymphocytes and elevated serum as well as induced sputum interleukin-17 levels compared with healthy subjects. Moreover, all studied allergic asthma patients, especially with early- and late-phase asthmatic reaction, showed an enhanced airway and systemic Th17 lymphocyte response 7 h and 24 h after bronchial challenge. We documented an enhanced local and systemic Th17 lymphocyte response to inhaled D. pteronyssinus in association with late-phase allergen-induced airway inflammation in patients with allergic asthma.

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De, Poi Rossella. « Mass spectrometry as an emerging tool for the detection of proteins in complex matrices : from untargeted to targeted analysis ». Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3425394.

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My PhD was performed in Mérieux NutriSciences, a company which provides analytical services. During my PhD I worked on three projects, whose common determinant was the application of mass spectrometry (MS) to the analysis of proteins. The main study deals with MS as a new tool for the analysis of food allergens. Food allergy is an important health problem involving immunological reactions that arise following exposure to protein allergens. In the absence of a cure, patients need to avoid the offending food to prevent allergic reactions. In the European Union, 14 allergens must be indicated in food labels when intentionally added. However, one of the main causes triggering allergic reactions is represented by undesired contamination of food by allergens in production facilities. Even tiny amounts of allergens can trigger severe manifestations; thus, to protect consumers sensitive analytical methods are required. Recently, methods based on MS have received increasing attention for the quantification of food allergens in complex matrices. In the present study, the development of a method based on MS for the simultaneous detection of egg, milk, tree nuts and peanuts allergens into bakery products is described. The method is based on the detection of specific peptides generated from the enzymatic hydrolysis of the target allergens and employs a technique called Multiple Reaction Monitoring, in which the mass spectrometer is operated to selectively acquire signals deriving from specific couples of m/z values, corresponding to a peptide ion and to one of its fragments. The method developed allows to detect target allergens in a specific way and with acceptable sensitivities and can be considered as a valuable alternative to other common analytical techniques, such as ELISA and PCR. A second topic of this thesis is bovine beta-casein, a polymorphic protein for which 12 genetic variants have been identified, the most common being A1 and A2. Some reports suggested a possible association between the consumption of A1 beta-casein and the etiology of some human diseases, including ischemic heart disease and diabetes. At the basis of the effects caused by A1 beta-casein there would be a bioactive peptide with opioid-like activity, released by proteolytic enzymes upon gastrointestinal digestion. This peptide, called beta-casomorphin-7, was shown to be produced only from certain beta-casein isoforms, having a histidine in position 67, including the A1 variant. On the other hand, variants possessing a proline in position 67, such as the A2 variant, would not be able to generate beta-casomorphin-7. Based on these assumptions, some companies now sell “A2 milk”, a milk containing only A2 beta-casein. In this project, a LC-MS analytical method was developed to discriminate between A2 milk and commercial milk, which typically contains a mixture of A1 and A2 beta-casein. The final purpose is to offer milk producers an analytical tool to certify that a milk labeled as “A2 milk” is really as such, eventually capable to identify possible frauds or contaminations. Finally, in this thesis a minor project is described, having as object the enzyme transglutaminase (TGase) from microbial origin. TGase catalyses the formation of isopeptide bonds between carboxamides of glutamine residues and amine groups of lysine, resulting in protein cross-linking. The action of TGase can determine significant changes in the physico-chemical properties of proteins, leading to changes in viscosity, thermal stability and elasticity. For these reasons, TGase finds application as an additive in the food industry. In this study a TGase from an unknown microbial source has been characterized and identified by applying a bottom-up proteomic approach. The identified enzyme is produced from a bacterial strain different from the one most commonly used in food industrial applications, S. mobaraense. Moreover, a method for the measurement of TGase enzymatic activity by the hydroxamate assay has been set up and has now become a service offered by the Mérieux NutriSciences.
Il mio dottorato di ricerca si è svolto in Mérieux NutriSciences, un’ azienda che fornisce servizi analitici. Durante il mio periodo di dottorato ho lavorato su tre progetti, il cui determinante comune era l'applicazione della spettrometria di massa (SM) all'analisi delle proteine. Lo studio principale riguarda la SM applicata all'analisi degli allergeni alimentari. L'allergia alimentare è una patologia importante, dovuta a reazioni immunologiche che insorgono a seguito dell'esposizione di un soggetto ad allergeni proteici. Poiché ad oggi non esiste cura, per prevenire le reazioni allergiche i pazienti devono evitare di assumere alimenti contenenti allergeni. Nell'Unione Europea, 14 allergeni devono essere indicati sulle etichette degli alimenti se aggiunti intenzionalmente. Tuttavia, una delle principali cause di reazione allergica è rappresentata dalla contaminazione indesiderata degli alimenti con allergeni all'interno degli impianti di produzione. Anche piccole quantità di allergene possono scatenare gravi reazioni; dunque, per proteggere i consumatori sono necessari metodi analitici sensibili. Recentemente, i metodi basati sulla SM hanno ricevuto crescente attenzione per la quantificazione degli allergeni alimentari in matrici complesse. Nel presente studio viene descritto lo sviluppo di un metodo basato sulla SM per il rilevamento simultaneo di allergeni da uova, latte, arachidi e frutta secca in prodotti da forno. Il metodo si basa sull'identificazione di specifici peptidi generati dall'idrolisi enzimatica degli allergeni target ed impiega una tecnica chiamata Multiple Reaction Monitoring, in cui lo spettrometro di massa è utilizzato per acquisire selettivamente segnali derivanti da coppie di specifici valori m/z, corrispondenti a uno ione peptidico e ad uno dei suoi frammenti. Il metodo sviluppato consente di rilevare gli allergeni target in modo specifico e con sensibilità accettabile e può essere considerato una valida alternativa ad altre comuni tecniche analitiche, come l’ELISA e la PCR. Un secondo argomento trattato in questa tesi riguarda la beta-caseina bovina, una proteina polimorfica per la quale sono state identificate 12 varianti genetiche, fra cui le più comuni sono la A1 e la A2. Alcuni studi hanno suggerito una possibile associazione fra il consumo di beta-caseina A1 e l'eziologia di alcune malattie, tra cui l’ischemia cardiaca e il diabete. Alla base degli effetti causati dalla beta-caseina A1 ci sarebbe un peptide bioattivo con attività simil-oppiode, rilasciato da specifici enzimi proteolitici durante la digestione. Questo peptide, chiamato beta-casomorphin-7, viene generato solo a partire da alcune isoforme di beta-caseina, contenenti un'istidina in posizione 67, inclusa la variante A1. Al contrario, le varianti che possiedono una prolina in posizione 67, come la variante A2, non sarebbero in grado di generare il peptide beta-casomorphin-7. Sulla base di queste ipotesi, alcune aziende vendono ora il cosiddetto "latte A2", un tipo di latte contenente solo beta-caseina A2. In questo progetto di dottorato è stato sviluppato un metodo analitico LC-MS per discriminare il latte A2 dal latte commerciale, che tipicamente contiene una miscela di beta-caseina A1 e A2. Lo scopo finale è offrire ai produttori di latte uno strumento analitico per certificare che un latte etichettato come "latte A2" sia realmente tale, ed eventualmente in grado di identificare possibili frodi o contaminazioni. Infine, in questa tesi viene descritto un progetto che ha come oggetto l'enzima transglutaminasi (TGasi) di origine microbica. La TGasi catalizza la formazione di legami isopeptidici tra residui di glutammina e di lisina, determinando la formazione di cross-linking fra proteine. L'azione della TGasi può determinare cambiamenti significativi nelle proprietà fisico-chimiche delle proteine, portando a modifiche nella viscosità, nella stabilità termica e nella elasticità. Per questi motivi, la TGasi trova applicazione come additivo nell'industria alimentare. In questo studio, una specie di TGasi di origine microbica è stata caratterizzata e identificata applicando un approccio proteomico “bottom-up”. L'enzima identificato viene prodotto da un ceppo batterico diverso da quello più comunemente utilizzato nelle applicazioni industriali alimentari, denominato S. mobaraense. Infine, è stato sviluppato un metodo per la misurazione dell'attività enzimatica della TGasi mediante il saggio dell'idrossammato, che è ora diventato un servizio analitico offerto da Mérieux NutriSciences.

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Livres sur le sujet "Allergia al latte"

1949-, Dorsch Walter, dir. Late phase allergic reactions. Boca Raton, Fla : CRC Press, 1990.

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1949-, Dorsch Walter, dir. Late phase allergic reactions. Boca Raton : CRC Press, 1990.

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Late Phase Allergic Reactions. Taylor & Francis Group, 1990.

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VanMeer, Mary. Allergies : The ultimate treatment guide, traditional, non-traditional, international, and late-breaking treatments. National Health and Medical Information Center, 1992.

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Rizzuto, Gabrielle A., et Anna I. Bakardjiev. Listeria monocytogenes. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190604813.003.0020.

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Listeria monocytogenes is a intracellular bacterial pathogen that causes serious foodborne illness in humans. Among all infectious diseases caused by gastrointestinal pathogens, listeriosis has the highest mortality rate, likely because of its ability to cross the gastrointestinal barrier and cause sepsis and infection of other organs such as the brain and placenta. Infection of the placenta leads to fetal infection, and otherwise healthy pregnant women have a significantly increased incidence of listeriosis than the general population, likely due to changes in the maternal cell-mediated immune response during pregnancy. Clinical manifestations include miscarriage, stillbirth, preterm labor, and neonatal infection and death. Neonates develop early-onset sepsis or late-onset meningitis. Physicians must evaluate pregnant women and neonates with febrile illnesses for listeriosis, since prompt treatment with antibiotics can cure it. It is important to note that L. monocytogenes is resistant to cephalosporins. Ampicillin is the treatment of choice in patients without penicillin allergy.

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Chapitres de livres sur le sujet "Allergia al latte"

Cavagni, G., M. C. Artesani, S. Donnanno, G. Trimarco et C. Riccardi. « Il trattamento dietetico del lattante con allergia alle proteine del latte vaccino ». Dans La pratica dell’atopia, 137–43. Milano : Springer Milan, 2008. http://dx.doi.org/10.1007/978-88-470-0775-8_23.

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Dorsch, W., et J. Ring. « Late Phase Reactions ». Dans New Trends in Allergy II, 174–97. Berlin, Heidelberg : Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-71316-3_20.

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Metzger, W. James, Kathleen Sjoerdsma, Hal B. Richerson, Pope Moseley, Donald Zavala, Marti Monick et Gary W. Hunninghake. « Platelets in Bronchoalveolar Lavage from Asthmatic Patients and Allergic Rabbits with Allergen-Induced Late Phase Responses ». Dans PAF, Platelets, and Asthma, 151–59. Basel : Birkhäuser Basel, 1987. http://dx.doi.org/10.1007/978-3-0348-7451-9_13.

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Brusasco, Vito, Emanuele Crimi et Giovanni A. Rossi. « Airway Responsiveness, Late-Phase Response, and Inflammation in Allergic Asthma ». Dans Asthma Treatment, 155–60. Boston, MA : Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3446-4_13.

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Larch�, M. « MHC-Restricted, IgE-Independent, Allergen Peptide-Induced Late Asthmatic Reactions ». Dans Immunological Mechanisms in Asthma and Allergic Diseases, 30–38. Basel : KARGER, 2000. http://dx.doi.org/10.1159/000058814.

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Golden, David B. K. « Patterns of Anaphylaxis : Acute and Late Phase Features of Allergic Reactions ». Dans Anaphylaxis, 101–15. Chichester, UK : John Wiley & Sons, Ltd, 2008. http://dx.doi.org/10.1002/0470861193.ch9.

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Schmitz, Jacques. « Prevention of Food Allergy during Late Infancy and Early Childhood ». Dans Nestlé Nutrition Workshop Series : Pediatric Program, 15–25. Basel : KARGER, 2005. http://dx.doi.org/10.1159/000086233.

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Möller, H., et Å. Carlsson. « Bioimplantation of Metals in Patients with Metal Allergy : The Late Outcome ». Dans Current Topics in Contact Dermatitis, 199–202. Berlin, Heidelberg : Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74299-6_39.

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Görtz, J., et M. Goos. « Immediate and Late Type Allergy to Latex : Contact Urticaria, Asthma and Contact Dermatitis ». Dans Current Topics in Contact Dermatitis, 457–59. Berlin, Heidelberg : Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74299-6_92.

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Pelikan, Z., et M. Pelikan-Filipek. « Cytologic Changes in the Nasal Secretions (NS) During the Immediate (INR) and Late Nasal Response (LNR) to Allergen Challenge (NPT) ». Dans Mediators in Airway Hyperreactivity, 55–62. Basel : Birkhäuser Basel, 1990. http://dx.doi.org/10.1007/978-3-0348-7379-6_5.

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Actes de conférences sur le sujet "Allergia al latte"

In, Seung Min. « Late Breaking Abstract - The effects of allergen (DP/DF) on mucociliary transport of allergic rhinitis patients ». Dans ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.pa4399.

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Hochgerner, Mathias, Eva M. Sturm, Diana Schnoegl, Grazyna Kwapiszewska, Horst Olschewski et Leigh M. Marsh. « Late Breaking Abstract - Hypoxia dampens the allergen-dependent adaptive immune response and ameliorates allergic asthma in vivo ». Dans ERS International Congress 2021 abstracts. European Respiratory Society, 2021. http://dx.doi.org/10.1183/13993003.congress-2021.pa2528.

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Raemdonck, Kristof, Jorge De Alba, Mark A. Birrell et Maria G. Belvisi. « A Role For Airway Sensory Nerves In The Allergen Induced Late Asthmatic Response In A Rat Model Of Allergic Asthma ». Dans American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a5542.

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Dixon, A. E., U. Peters, R. Walsh, N. Dapthary, E. S. Maclean, K. Hodgdon, D. A. Kaminsky et J. H. T. Bates. « Late-Onset Non-Allergic Asthma in Obesity : A Disease of Late-Onset Non-Allergic Asthma in Obesity : A Disease of Derecruitment ». Dans American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a4427.

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Shiraishi, Y., LE Burgess, K. Takeda, C. Eberhardt, D. Wright, A. Cook, C. Corrette et al. « CRTH2 Antagonism Prevents Early- and Late-Phase Responses in Allergic Rhinitis. » Dans American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a5718.

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Peters, U., D. A. Kaminsky, R. Walsh, C. M. Kinsey, E. Maclean, N. Daphtary, K. Hodgdon, J. H. T. Bates et A. E. Dixon. « Distinct Physiological Signature of Late-Onset Non-Allergic Asthma of Obesity ». Dans American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2226.

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Mahendran, Siva, Rosemary Ebling, Mohammad Ibrahim et Tariq Sethi. « LATE-BREAKING ABSTRACT : IgE immunadsorption in allergic bronchopulmonary aspergillosis : A pilot study ». Dans ERS International Congress 2016 abstracts. European Respiratory Society, 2016. http://dx.doi.org/10.1183/13993003.congress-2016.oa4835.

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Elholm, Grethe, Allan Linneberg, Lise Lotte Husemoen, Øyvind Omland, Pernille Milvang Grønager, Torben Sigsgaard et Vivi Schlünssen. « LATE-BREAKING ABSTRACT : The urban-rural gradient of allergic asthma in adults ». Dans Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.pa4084.

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Duchene, B., S. Ventrone, O. Johnson, J. Ather, S. Caffry, R. Chandrasekaran, M. Mank et al. « Obese Late Onset Non-Allergic Asthmatics Have Peripheral Airway Abnormalities and Mitochondrial Dysfunction ». Dans American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1411.

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Yang, Hyo-Seon, Jeongsik Park, Mikyung Song et Kyuhong Lee. « Late Breaking Abstract - Formaldehyde inhalation impairs immune system and may affects severity of allergic disease ». Dans ERS International Congress 2017 abstracts. European Respiratory Society, 2017. http://dx.doi.org/10.1183/1393003.congress-2017.pa1137.

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