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Littérature scientifique sur le sujet « Alloxan-induced diabetic rats »

Auteur : Grafiati

Publié le 7 juin 2025

Mis à jour le 2 août 2025

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Articles de revues sur le sujet "Alloxan-induced diabetic rats"

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Ahamefula Sunday Ezekwe, Karibo Amakiri Okari, Peter Gift Wokocha, Mike Tochi Achor, and Boma Ngo Fubara. "Evaluating alloxan-induced diabetic rats." International Journal of Science and Research Archive 13, no. 2 (2024): 3544–52. https://doi.org/10.30574/ijsra.2024.13.2.2499.

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The increasing incidence of diabetes and the adverse effects of chemical medications underscore the importance of exploring alternative non-pharmacological treatments. Vernonia amygdalina, a widely utilized medicinal herb, shows promising therapeutic potential. This study investigated the impact of aqueous leaf extracts of Vernonia amygdalina on various biochemical parameters in alloxan-induced diabetic rats. Diabetes was induced in male Wistar rats through intraperitoneal injection of alloxan (150 mg/kg). The rats were then randomly divided into four groups: Group 1 (normal control), Group 2

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Farheen, Mehnoor, and Chakrapani Ramesh. "Phytochemical evaluation and pharmacological screening of ethanolic and aqueous leaf extracts of Pupalia lappacea for antihyperlipidemic and antihyperglycemic activities in alloxan induced diabetic Albino wistar rats." International Journal of Basic & Clinical Pharmacology 7, no. 4 (2018): 753. http://dx.doi.org/10.18203/2319-2003.ijbcp20181182.

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Background: Diabetes is associated with damage to the liver, pancreas and kidney. The damage may vary among patients. This study assessed the hypoglycaemic and antihyperlipidemic activities of leaves ethanolic and aqueous extracts of Pupalia lappaceae in alloxan induced diabetic albino wistar rats.Methods: There were Fifty four rats divided into nine groups containing six rats each. Group 1 consists of normal rats that were given only normal saline and served as a control group. Group 2 consists of normal rats that were given alloxan monohydrate (150mg/kg b.w). Group 3 consists alloxan induced

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Sultana, S., N. Y. Mili, R. Afroz, and S. Parveen. "Preventive Role of Zingiber Officinale against Hyperglycemia in Alloxan Induced Diabetic Rats." Journal of Medical Science & Research 30, Number 1 (2019): 26–29. http://dx.doi.org/10.47648/jmsr.2019.v3001.05.

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The experimental animal study was undertaken to investigate the preventive role ginger juice against hyperglycemia in alloxan induced diabetic rats.Male wistar rats,(130-150)gm wt fed on standard diet and water ad libitum, were divided into 3 groups(n=6) in each group: Group-L non-diabetic control group, Group-II, diabetic control & Group-III, normal rats pretreated with ginger before they were made diabetics. Diabetes was induced by inj. alloxan 150mg/kg body wt.,tp (Group-IL on 2nd day & Group-Ill, on the 9th day).Rats having blood glucose level of more than 7mmol/L on day 5(72 hours

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Chidinma, Iwuji Joy, Nwanjo Harrison Ugochukwu, Nwosu Dennis C, Osuegbu Mercy Chukwujindu, and Ohaeri Evangelina Ozoemena. "Comparative Assessment of Histopathological and Biochemical Indices of Renal Function in Alloxan-induced Male and Female Diabetic Rats." Asian Journal of Medicine and Health 22, no. 8 (2024): 106–16. http://dx.doi.org/10.9734/ajmah/2024/v22i81075.

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It has been observed that alloxan-induced diabetes causes free radical production, which ultimately damages the pancreatic β-cells and impact several organs especially the kidney. This study was a comparative assessment of histopathological and biochemical indices of renal function in alloxan-induced male and female diabetic rats. A total of twenty-four (24) male and female albino wistar rats were divided into five groups (6 rats per group): normal control female (group A), normal control male (group B), diabetic female (group C) and diabetic male (group D). Diabetes mellitus was induced in th

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Sultana, Selima, Shakil Akter, and Md Ismail Khan. "Anti-Hyperlipidemic Action of Zingiber officinale (Ginger) Juice in Alloxan Induced Diabetic Rats." Ibrahim Medical College Journal 6, no. 2 (2013): 55–58. http://dx.doi.org/10.3329/imcj.v6i2.14730.

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Hyperlipidemia is an important modifiable risk factor contributing to atterosclerosis in diabetes mellitus. Zingiber officinale (ginger) widely consumed as spice is known for its hypoglycemic and hypochlosteremic actions. The present study was undertaken to investigate anti-hyperlipidemic action of ginger juice in alloxan-induced diabetic rats. Male Wister rats, 130-150 g wt, fed on standard diet and water ad libitum were divided into 4 groups (n=6 in each group): group I nondiabetic control, group II non-diabetic treated; group III diabetic control and group IV diabetic treated. Diabetes was

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Thilagam, Ellappan, Kumarappan Chidambaram, Chinthamreddy Raviteja, Thalu Vahana, and Parameshwaran Vasudevan. "Anti-hyperglycemic and hypolipidemic effects of Saraca asoca (Roxb.) Wild. flowers in alloxan-treated diabetic rats." Journal of Pharmacy & Pharmacognosy Research 9, no. 1 (2021): 58–68. http://dx.doi.org/10.56499/jppres20.894_9.1.58.

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Context: Saraca asoca (Leguminosae) has been widely used in the Ayurvedic system of medicine for various ailments, and it has been used to treat diabetes as a folk medicine. Aims: To investigate the anti-hyperglycemic and anti-hyperlipidemic effect of ethanolic extracts of S. asoca (EESA) flowers in alloxan-induced diabetic rats. Methods: The anti-hyperglycemic activity of EESA was evaluated by using normal and alloxan-induced (120 mg/kg, i.p.) diabetic rats. In the sub-chronic animal model of diabetes mellitus, EESA was orally administered to normal and alloxan-induced-diabetic rats at doses

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Ekinci, Bilge, Bahadir Suleyman, Renad Mammadov, et al. "The effect of carvacrol upon experımentally ınduced dıabetıc neuropathy and neuropathıc paın ın rats." Acta Poloniae Pharmaceutica - Drug Research 79, no. 5 (2023): 707–15. http://dx.doi.org/10.32383/appdr/155354.

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Diabetic neuropathies are the most frequent complication of diabetes. While numerous metabolic pathways are disrupted in diabetic neuropathy, oxidative stress has been indicated as a significant reason for this condition. In this study, the effect of carvacrol, which has antioxidant effects, on experimental diabetic neuropathy and neuropathic pain was investigated. Alloxan was used to induce diabetes in the experiment. Diabetes was created by administering 120mg/kg of alloxan intraperitoneally (i.p) once a day for 3 days. Rats with a blood glucose concentration above 250mg/kg in the blood take

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Hussaini, SMAK, MI Hossain, MS Islam, and K. Rafiq. "Effects of Spirulina platensis on alloxan induced diabetic rats." Progressive Agriculture 29, no. 2 (2018): 139–46. http://dx.doi.org/10.3329/pa.v29i2.38300.

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The study was undertaken to investigate the effects of Spirulina platensis on body weight, blood glucose and lipid profile on alloxan induced diabetic rats. Fifteen Long Evans male rats at six weeks of age were used for the experiment. Diabetes was induced by intraperitoneal injection of alloxan@ 150 mg/kg and experiment was carried out for a period of 6 weeks. Rats were divided into three groups of 5 rats each. The groups were i)healthy control, ii) diabetic control with both receiving rats’ pellet as supplement, and iii) diabetic treated with oral administration of Spirulina platensis @ 400

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Gu, Peng-Cheng, Lan Wang, Mei-Na Han, et al. "Comparative Pharmacokinetic Study of Mangiferin in Normal and Alloxan-Induced Diabetic Rats after Oral and Intravenous Administration by UPLC-MS/MS." Pharmacology 103, no. 1-2 (2018): 30–37. http://dx.doi.org/10.1159/000493364.

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Backgrounds: Diabetes mellitus (DM)-induced morphological and/or functional complications may alter the pharmacokinetic profiles of mangiferin. This study aims to compare pharmacokinetic profiles of mangiferin in normal and alloxan-induced diabetic rats after oral and intravenous administration. Methods: Mangiferin was administered orally (10 mg/kg) and intravenously (2 mg/kg) to normal and alloxan-induced diabetic Sprague-Dawley (SD) rats (n = 8). Blood samples were collected at different time points post-dose. Mangiferin and esculentoside (internal standard) were analyzed by Waters Acquity u

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Rahman, AFM Towheedur, Md Saiful Islam, Md Hazrat Ali, et al. "Nigella sativa Oil Potentiates the Effects of Pioglitazone on Long Term Alloxan-Induced Diabetic Rats." Bangladesh Pharmaceutical Journal 16, no. 2 (2015): 143–51. http://dx.doi.org/10.3329/bpj.v16i2.22296.

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The present study was designed to investigate the effects of combination of Nigella sativa oil and pioglitazone on long-term alloxan-induced diabetic rats. In short-term (two weeks) alloxan-induced diabetic rats, N. sativa oil (NSO) reduced significant amount of glucose in blood, TC, TG and LDL-C and increased significant amount of HDL-C compared to diabetic rats. However, pathological changes of pancreass Islets of Langerhans were observed after long-term (four weeks) induction of alloxan in rats. Administration of NSO recovered Langerhans cells from shrinkage whereas pioglitazone displayed

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Thèses sur le sujet "Alloxan-induced diabetic rats"

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Davydova, N. V. "The influence of melatonin on glutathione-S-transferase activity in the kidneys of rats under alloxan-induced diabetes." Thesis, БДМУ, 2017. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/16860.

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pei-hui, Wang, and 王珮憓. "The Study of Hypoglycemic Effects of Toona Sinensis Aqueous Leaf Extracts on Alloxan-induced Diabetic Rats." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/86408924252570713206.

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碩士<br>高雄醫學大學<br>醫學研究所<br>89<br>Toona sinensis (TS) is a broadleaf tree, which grows all around the world, which is composed of only four or five ‘good’ species. TS are the only Toona species in which the leaflet margins can be serrate to serrulate. The trees provide very high quality timber and are widely used medicinally, the bark being used as an astringent and depurative, the root as a refreshment and a diuretic, the tender leaves as a carminative and a corrective, and the fruits as an astringent and for treatment of eye infections. The leaves and young shoots have been used as a vegetable

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Bi, Yi Jia. "Alterations in cardiac responses to adrenergic agonists and in circulating thyroid hormones in alloxan induced diabetic rats." Thesis, 1994. http://hdl.handle.net/2429/5119.

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The effects of adrenergic agonists in the heart were investigated in isolated cardiac tissues and in the whole heart in 8 week diabetic and age-matched control rats by measuring contractile force following administration of PE in presence of timolol, or ISO. Plasma thyroid hormones as well as insulin, glucose and triglyceride was measured. The contractile force of the isolated cardiac tissues was measured in tissue baths under physiological conditions and results expressed by construction of concentration response curves to adrenoceptors agonists, 10⁻⁹ to 10⁻⁴ M for ISO and 10⁻⁷ to 10⁻³

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"Study of the determining mechanisms of the hyporeactivity of mast cells in diabetes experimental induced for alloxan in rats." Tese, Biblioteca Digital de Teses e Dissertações da Fiocruz, 2006. http://www.bdtd.cict.fiocruz.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=42.

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Chapitres de livres sur le sujet "Alloxan-induced diabetic rats"

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Shanmuganathan, T., and A. V. P. Karthikeyan. "Evaluation of Anti-diabetic Activity of Cleome gynandra in Alloxan Induced Diabetic Wistar Albino Rats." In Phytomedicine. CRC Press, 2020. http://dx.doi.org/10.1201/9781003014898-18.

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Renuka, C., K. Saravanan, and P. Karuppannan. "Hypoglycemic Activity of Biophytum sensitivum Whole Plant Extracts on Alloxan Induced Diabetic Rats." In Drug Development for Cancer and Diabetes. Apple Academic Press, 2020. http://dx.doi.org/10.1201/9780429330490-23.

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Golfman, Leonard, Ian M. C. Dixon, Nobuakira Takeda, Anton Lukas, Krishnamurti Dakshinamurti, and Naranjan S. Dhalla. "Cardiac sarcolemmal Na+-Ca2+ exchange and Na+-K+ ATPase activities and gene expression in alloxan-induced diabetes in rats." In Molecular and Cellular Effects of Nutrition on Disease Processes. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5763-0_11.

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Olusanya, Arise Rotimi, Bankole S. Ifeoluwa, Aboyewa Jumoke A., and Bobbo Khadijat. "Antidiabetic and Safety Properties of Ethanolic Leaf Extract of Corchorus olitorius in Alloxan-Induced Diabetic Rats." In Diabetes Food Plan. InTech, 2018. http://dx.doi.org/10.5772/intechopen.71529.

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Nwankwo, Michael O., Innocent O. Ogbonna, and Etim, Esin Etim. "Determination of the Anti-diabetic Activity of Sphenostylis stenocarpa Seed Milk Extract in Alloxan-induced Diabetes Rats." In Recent Developments in Medicine and Medical Research Vol. 16. Book Publisher International (a part of SCIENCEDOMAIN International), 2021. http://dx.doi.org/10.9734/bpi/rdmmr/v16/5210f.

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Sultana, Fatima, Rama Rao, and Anupama K. "Screening of Antidiabetic Activity of Crude Extract of Celastrus Paniculatus in Alloxan Induced Diabetic Rat Model." In Current Trends in Drug Discovery, Development and Delivery (CTD4-2022). Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/9781837671090-00685.

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Diabetes mellitus is the commonest form of endocrine disorder that is characteristic of hyperglycaemia. This is due to a defective metabolic system of fat, proteins, and carbohydrates leading to major health challenges. Around 800 medicinal plants have hypoglycaemic properties worldwide. Diabetic complications can be slowed and metabolic abnormalities can be restored by the use of plant products. The antidiabetic property of Celastrus paniculatus seed extract (CPSE) is studied. The seeds containing phytochemicals - alkaloids, sterols, triterpenoids, flavonoids, saponins, and tannins were evalu

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Karan, Sanjay Kumar, Dilipkumar Pal, Sagar Kumar Mishra, and Arijit Mondal. "Investigating the Antihyperglycaemic Effect of Vetiveria zizanioides (L.) Nash Root Extract in Alloxan-induced Diabetic Rats." In Advanced Concepts in Pharmaceutical Research Vol. 9. B P International, 2024. http://dx.doi.org/10.9734/bpi/acpr/v9/3638g.

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Kasolo, Josephine N., Agnes Namaganda, Joshua Nfambi, et al. "Hyperglycemic Control of Moringa oleifera Leaves Aqueous Extract and Glibenclamide Tablets in Alloxan Monohydrate Induced Diabetic Rats: A Comparative Analysis." In Current Overview on Pharmaceutical Science Vol. 9. B P International (a part of SCIENCEDOMAIN International), 2023. http://dx.doi.org/10.9734/bpi/cops/v9/17898d.

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Actes de conférences sur le sujet "Alloxan-induced diabetic rats"

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"Antidiabetic effect of Ziziphus Jujuba fruit in Alloxan induced diabetic male rats." In International Conference on Medicine, Public Health and Biological Sciences. CASRP Publishing Company, Ltd. Uk, 2016. http://dx.doi.org/10.18869/mphbs.2016.61.

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"Antidiabetic effect of Rosa canina L. fruit in alloxan induced diabetic male rats." In International Conference on Medicine, Public Health and Biological Sciences. CASRP Publishing Company, Ltd. Uk, 2016. http://dx.doi.org/10.18869/mphbs.2016.230.

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Stolbovskaya, Olga, Boris Kostishko, Radik Khayrullin, and Rinat Bakhtiyarov. "Structural features of blood lymphocytes according to data of atomic force microscopy in alloxan induced diabetic rats." In Saratov Fall Meeting 2017: Fifth International Symposium on Optics and Biophotonics: Optical Technologies in Biophysics & Medicine XIX, edited by Valery V. Tuchin, Dmitry E. Postnov, Elina A. Genina, and Vladimir L. Derbov. SPIE, 2018. http://dx.doi.org/10.1117/12.2315077.

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Caverina, Sarah Lorenza, Retno Yulianti, and Andri Pramesyanti. "Effectiveness of Soursop Leaf Extract to Decrease Malondialdehyde Level." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.05.07.

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ABSTRACT Background: In diabetes mellitus, hyperglycemia causes oxidative stress that enhances the production of free radicals. The presence of higher levels of malondialdehyde (MDA) indicates the rise of free radicals. On the basis of its role as an antioxidant that binds free radicals and reduces the level of malondialdehyde (MDA). Soursop leaf can act as an antidiabetic agent. This study aimed to examine the efficacy of soursop leaf extract (Annona muricata L.) to decrease the level of MDA level in alloxan-induced diabetic rats (Rattus norvegicus). Subjects and Method: This was an experimen

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"Effects of Punicagranatum fruits extract on insulin gene expression and insulin signaling pathway in Alloxan-induced diabetic Wistar rats." In International Conference on Medicine, Public Health and Biological Sciences. CASRP Publishing Company, Ltd. Uk, 2016. http://dx.doi.org/10.18869/mphbs.2016.164.

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Enechi, Osmund Chukwuma, Emmanuel Sunday Okeke, Destiny Chidiebere Arum, and Stephen Chijioke Emencheta. "Attenuation of Haematological and Biochemical Alterations in Alloxan-Induced Diabetic Rats Using Ethanol Extract from Annona senegalensis Persoon (Annonaceae) Leaves." In The 4th International Electronic Conference on Applied Sciences. MDPI, 2023. http://dx.doi.org/10.3390/asec2023-16524.

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Samsulrizal, Nurdiana, Zanariah Awang, Mohd Luqman Hakim Mohd Najib, Mohd Idzham, and Abu Zarin. "Effect of Ficus deltoidea leaves extracts on sperm quality, LDH-C4 activity and testosterone level in alloxan-induced male diabetic rats." In 2011 IEEE Colloquium on Humanities, Science and Engineering (CHUSER). IEEE, 2011. http://dx.doi.org/10.1109/chuser.2011.6163864.

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Singh, Ranbir. "IDDF2019-ABS-0266 Effects of thyroid hormone treatment on hepatic glucose production and renal reabsorption of glucose in alloxan-induced diabetic wistar rats." In International Digestive Disease Forum (IDDF) 2019, Hong Kong, 8–9 June 2019. BMJ Publishing Group Ltd and British Society of Gastroenterology, 2019. http://dx.doi.org/10.1136/gutjnl-2019-iddfabstracts.106.

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Adefolaju, Oluwaferanmi, Julius Arannilewa, and Ayokanmi Olowo. "Effect of administration of aqueous extracts of Securidaca longepedunculata stem barks on enzymes of the small intestine alloxan-induced diabetic rats." In 5th International Electronic Conference on Medicinal Chemistry. MDPI, 2019. http://dx.doi.org/10.3390/ecmc2019-06276.

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Ogundolie, Frank, Grace Adebayo-gege, Ruqayah A. Aliyu, Queen Ozegbe, Aasia J. Muhammed, and Toyin D. Alabi. "Green Silver Nanoparticles Synthesized fromMoringa OleiferaStem Bark Elicits Effective Antidiabetic Effect in Alloxan-Induced (Type I) Diabetic Wistar Rats." In ASPET 2024 Annual Meeting Abstract. American Society for Pharmacology and Experimental Therapeutics, 2024. http://dx.doi.org/10.1124/jpet.081.926380.

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Rapports d'organisations sur le sujet "Alloxan-induced diabetic rats"

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Yibchok-anun, Sirintorn, and Wara Panichkriangkrai. The role of arginine vasopressin in diabetes-associated glucagons secretion. Chulalongkorn University, 2002. https://doi.org/10.58837/chula.res.2002.63.

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The purpose of this study was to investigate the role of arginine-vasopressin (AVP) on glucagons secretion in both normal and diabetic rats. Diabetes was induced by intraperitoneal administration of alloxan HCI(200 mg/kg). Both glucagon and AVP were determined in the effluent of the perfused pancreas using radioimmunoassay. Diabetic rats had higher baseline glucagons concentrations than normal rats. AVP (1 pmol/L) failed to change glucagons secretion in normal rats, but significantly increased glucagons secretion in diabetic rats. AVP (10-100 pmol/L) increased glucagons secretion from both nor

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